CN105943951A - Medicine composition for treating lung paralysis and preparation method of medicine composition - Google Patents
Medicine composition for treating lung paralysis and preparation method of medicine composition Download PDFInfo
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Abstract
The invention provides a medicine composition for treating lung paralysis and a preparation method of the medicine composition. The preparation method comprises the following steps: conducting ethanol extraction on 3-6 parts of rhizoma anemarrhenae, 2-5 parts of semen raphani, 2-5 parts of Stephania terandra, 6-10 parts of aster, 1-3 parts of radix asparagi, 1-3 parts of Bletilla striata, 8-10 parts of Draba nemorosa, 1-3 parts of mulberry bark, 1-3 parts of Coix seeds, 2-5 parts of tendril-leaved fritillary bulb, 1-3 parts of lily, 3-6 parts of Radix Ophiopogonis, 2-5 parts of radix scrophulariae, 1-3 parts of birthwort, 3-6 parts of Eucommia ulmoides, 3-6 parts of loquat and 1-3 parts of honeysuckle, carrying out concentration, then mixing the obtained concentrated solution with 7-10 parts of malt sugar, 3-5 parts of rock sugar, 3-5 parts of almond and 7-10 parts of a starch solution, and then drying. The medicine composition provided by the invention has the effect of quickly solving the symptoms of lung paralysis, and has the characteristics of scientific prescription, simple preparation method, low processing cost, obvious curative effect, convent taking, no toxic or side effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition treating consumptive lung disease and
Its preparation method.
Background technology
Consumptive lung disease, has another name called lung and withers.Referring to that lobe of the lung flaccidity is weak need not be clinical based on expectorating thick saliva
Disease, for the chronic deficient property illness of lungs.Consumptive lung disease is the chronic weak illness of deficiency of YIN lung wound.
Cardinal symptom is cough, and spue thick expectorant foam, or with cold and heat, emaciated physique, spirit is withered
Waste, the diseases such as cardiopalmus is panted, xerocheilia, pulse condition imaginary number.Primary disease many superventions what Other diseases
Or after wrong treatment, body fluid consumes again and again, yin asthenia generating intrinsic heat, lung is caused by smoked burning.If it is sick long
Feel frustrated or deficiency and coldness and cause person in lung, then show as yang deficiency, patient's excessive saliva, normal discharge saliva foam
And without cough.Can be with the symptom such as dizziness, the enuresis." in the cough of Medical Treasures of the Golden Chamber consumptive lung disease lung abscess
Disorder of QI arteries and veins card is controlled ": " heat in upper-JIAO person, pulmonary flaccidity caused by cough.What the disease of consumptive lung disease, obtain it from?
Teacher says: " or from sweating, or from vomiting, or from quenching one's thirst, frequent urination, or from dyschezia, again
By profit under fast medicine, extreme exhaustion of body fluid, therefore obtain it.Saying: pulse at CUN KOU being rapid, its people coughs, anti-in mouth
How there is thick sputum saliva foam person?Teacher says: for the disease of consumptive lung disease." " consumptive lung disease spitting saliva without cough person, its
People is thirsty, must the enuresis, frequent micturition, reason person, deficiency of the upper portion of the body resulting in inability to control the lower portion thus also, this is lung
In cold, must string, excessive saliva." have deficiency-heat, deficiency and coldness point.Deficiency-heat person, coughs sound bad-looking, tells
Sticky saliva foam, dry mouth and throat, dyspnea with rapid breath, emaciated physique, or see hectic fever, dry skin and hair,
Dry tongue is red, deficient and rapid pulse etc..
Doctor trained in Western medicine uses naturopathy cooperation to give antibiotic for the initial therapy of the patient of consumptive lung disease
Treatment.Repeatedly serious respiratory tract infection or repeatedly spitting of blood person be considered as the lobe of the lung or lung section are made hands
Art is excised.The consumptive lung disease that tumor causes should be according to cell type and extent of disease, the whole body of patient
Situation and pulmonary function, consider employing operation, radiotherapy or chemotherapy to alleviate
Consumptive lung disease disease, but there is the biggest side effect, and the prescription of Chinese traditional treatment cough is various, each
The specific aim of prescription is different, and the decoction of Chinese medicine decoction and taking all is inconvenient for, and decocts
Time brings the biggest impact with taking improper meeting to treatment, it is therefore desirable to one can either have
Effect treatment consumptive lung disease symptom, the medicine can conveniently taken again is to solve patient suffering.
Summary of the invention
In order to overcome above-mentioned prior art defect, it is an object of the invention to provide a kind for the treatment of
Pharmaceutical composition of consumptive lung disease and preparation method thereof, from motherland's medical treasure-house, according to traditional Chinese medical science group
Fong theory, skims the cream off milk, and reconfigures, and uses the preparation of modern pharmaceutical means notable to consumptive lung disease
Effective certain drug.
In order to solve above-mentioned technical problem, the present invention takes following technical scheme:
A kind of pharmaceutical composition treating consumptive lung disease, its weight composition includes: the Rhizoma Anemarrhenae 3~5 parts,
Semen Raphani 2~4 parts, Radix Stephaniae Tetrandrae 2~4 parts, Radix Asteris 7~10 parts, Radix Asparagi 1~3 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1~3
Part, Semen Lepidii 8~10 parts, Cortex Mori 1~3 parts, Semen Coicis 1~3 parts, Bulbus Fritillariae Cirrhosae 2~5 parts, Bulbus Lilii 1~3
Part, Radix Ophiopogonis 3~6 parts, Radix Scrophulariae 2~5 parts, Radix Ginseng 1~3 parts, Radix Adenophorae (Radix Glehniae) 1~3 parts, Radix Codonopsis 1~3
Part, Radix Scrophulariae 1~3 parts, Fructus Aristolochiae 1~3 parts, the Cortex Eucommiae 3~6 parts, 3~6 parts, Fructus Schisandrae Chinensis 1~3
Part, Radix Ophiopogonis 1~3 parts, Semen Armeniacae Amarum 3~5 parts, maltose 7~10 parts.
Further, described pharmaceutical composition also includes: crystal sugar 3~5 parts, pulp-water 7~10 parts.
Further, optimum weight part of described pharmaceutical composition consists of: the Rhizoma Anemarrhenae 5 parts,
Semen Raphani 4 parts, Radix Stephaniae Tetrandrae 3 parts, Radix Asteris 7 parts, Radix Asparagi 2 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1 part, Semen Lepidii 10
Part, Cortex Mori 1 part, Semen Coicis 2 parts, Bulbus Fritillariae Cirrhosae 3 parts, Bulbus Lilii 3 parts, Radix Ophiopogonis 4 parts, Radix Scrophulariae 5
Part, Radix Ginseng 2 parts, Radix Adenophorae (Radix Glehniae) 1 part, Radix Codonopsis 1 part, Radix Scrophulariae 1 part, Fructus Aristolochiae 1 part, the Cortex Eucommiae 4
Part, Folium Eriobotryae 5 parts, Fructus Schisandrae Chinensis 2 parts, Radix Ophiopogonis 2 parts, maltose 9 parts, 4 parts of Semen Armeniacae Amarum, crystal sugar 3
Part, pulp-water 8 parts.
Wherein, the primarily serving the purpose of of above-mentioned constituent:
Rhizoma Anemarrhenae bitter cold, abnormal smells from the patient is the thickest, sinks and declines, and for this medicine of kidney channel, energy lung heat clearing of holding concurrently, rushes down
The fire mutually having a surplus, the tired steaming that reason is quenched one's thirst, all cough-relievings are antiabortive, are used is it possible that relieve inflammation or internal heat.Bitter in the mouth,
Pungent, gas Great Cold, heavy and drop, the moon is also, nontoxic.Enter foot yin, yang less bright, start with again lunar.
Kind rush down stomach, kidney two through fire, only heat of quenching one's thirst, also control chronic malaria, belong to gunpowder under heat clearing away, main
Control: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, fidgets due to deficiency
Sleeplessness, stranguria with turbid discharge of quenching one's thirst;Clearing away heat-fire, promotes the production of body fluid and moisturizes.Clearing away heat-fire, promotes the production of body fluid and moisturizes.With
In fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat quenches one's thirst, and dryness of the intestine is just
Secret.
Semen Armeniacae Amarum, sweet in the mouth, hardship, temperature, can rise and can drop, cloudy middle-jiao yang, function of the spleen and stomach also, specially enters lunar lung meridian;
Being profit purgation agent, remove dyspnea due to adverseness of QI in the heart, cough-relieving is coughed, pendant expectorant, profit large intestine, gas-tight dyschezia,
By numbness eliminating stagnation.
Semen Raphani property is put down, acrid in the mouth, sweet, returns lung, spleen, stomach warp, has the de-swelling that helps digestion, sending down the abnormal ascending QI
The merit reduced phlegm;Stop up for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant
Breath with cough.Entering spleen, stomach, lung meridian, can help digestion de-swelling, "Nei Jing" cloud: " gather in stomach, about
Lung." the receiving of taste, transport, ascending, descending not normal, diet turbid damp gathers and forms expectorant in stomach.And lung it
Expectorant, often by lungs by heresy, clear respectful mistake department is caused;With Semen Raphani eliminate indigestion and phlegm, therapeutic method to keep the adverse QI flowing downwards Dingchuan,
Make storehouse report without turbid poly-, ask it also;With Semen Raphani, expectorant is had then to break its source;Then regulate without expectorant
QI of the spleen and stomach machine, lifts degree of having, and heresy is deposited from difficulty.
Semen Coicis, slightly sweet flavor, feeble QI is cool, and property edges down and oozes, therefore the diuretic that can dry, with its will
Wet, therefore energy profit joint, except tinea pedis, control flaccidity weak contracture arthralgia chiefly caused by damp pathogen, consumer edema pain, diuresis
Pyretic stranguria, also kills ascarid.Edging down with it, therefore also control cough saliva pus, profit diaphragm appetizing, with its property
Cool, therefore can heat clearing away, only excessive thirst, upper gas.
Semen Lepidii hardship fall is pungent to be dissipated, and cold, therefore can break stagnant relieving accumulation of pathogens, determines check and breathes heavily, and diuretic disappears
Swollen;" herbal classic " cures mainly, and all lets out as justice with broken;The only product of diarrhea due to cold pathogen, having a surplus of energy tonneau pathogen,
Can not the deficiency of tonification healthy energy, Gou Feishi heat stagnation stops up, from being scrupled when knowing;" not Lu " takes for a long time
Make us empty, be originally famous dictum;So lung man phlegm-fire is jammed, and cold fluid-retention fills the air, dyspnea with rapid respiration tachypnea, or
Demonstrate,prove for swelling etc., this also must be relied to wear armor and carry weapons, to become to smash the achievement in plough front yard, cave.
Radix Stephaniae Tetrandrae, acrid in the mouth, hardship, flat, warm, nontoxic.Treat edema, swelling due to wind, go bladder heat,
Typhoid fever, cold and heat pathogen, apoplexy hands muscle spasm of the leg and foot, stopping leak, dissipate carbuncle, dislike and tie, all snail scabies,
Worm skin ulcer, logical space between skin and muscles, profit nine orifices.
Pseudobulbus Bletillae (Rhizoma Bletillae) bitter in the mouth, sweet, puckery, cold nature;Attach to the lung and stomach meridians;Matter is viscous holds back puckery, and can dissipate can
Receive, there is astringing to arrest bleeding, effect of detumescence and promoting granulation;Cure mainly pulmonary tuberculosis spitting of blood, spit blood, epistaxis,
Have blood in stool, traumatic hemorrhage, ulcerative carbuncle toxic swelling, scrofula, anal fistula, burn and scald, rhagadia manus et pedis, anus
Split.
Cortex Mori gas is trembled with fear, and sweet in the mouth is nontoxic, enters lung meridian, spleen channel;Main damaging the spleen and stomach, five kinds of over strain six types of severe debility disease,
The exhausted arteries and veins of weakness and emaciation metrorrhagia, can qi-restoratives QI invigorating;Controlling lung qi dyspnea with fullness of the chest, aqueous vapor edema, main wound is exhausted, profit
Water channel, disappear aqueous vapor, asthenia exopathogenic heat, headache, interior tonifying for the deficiency.
Radix Asparagi, moisturizes YIN nourishing, and the medicine of pathogenic fire reducing lung heat clearing is also.System reason lung kidney fire is dry is disease, as
The scorehed lung-lobe due to lung-heat, sending out is flaccidity carbuncle, cough of spitting blood, and excessive thirst biography is diabetes involving the kidney, hectic fever due to YIN-deficiency Re Laozhu card,
The required person of institute also.Forefathers have meaning except inclined numbness, bone strengthening marrow person, because lung-heat becomes flaccidity, kidney-heat marrow
Withered, the muscle inclined numbness person of withered not Rong Ercheng is also.Radix Asparagi the moon profit is cold mends, and makes dry person moisten, and hot person is clear,
Then bone marrow is strong, and inclined numbness can profit.So must with unit deficiency-heat victor preferably it.
Radix Asteris bitter in the mouth, warm in nature, nontoxic, can expectorant quench the thirst, nourishing the lung to keep the adverse QI downward, for phlegmatic cough blood labor
Panacea, cough the miracle of vomiting bloody pus.Maltose, sweet in the mouth, warm in nature, return spleen channel, stomach through, lung
Warp, have slow in, qi-restoratives, the merit promoting the production of body fluid, moisturize, cure mainly overstrain impairing the spleen, pain in the abdomen stomachache,
Xeropulmonary cough, haematemesis, thirsty, pharyngalgia, constipation.Sweet enter spleen, and rice wheat all support taste it
Thing, therefore main qi-restoratives is weary, lung stomach has fire then to send out yearningly, and scorching on fire, the absurd row of forcing blood is then spitted blood, sweet
When energy delays fire, then fire declines and the most certainly stops, and blood is from going also.
Bulbus Fritillariae Cirrhosae is cool in nature, Gan Ping;Enter lung meridian, stomach warp, can nourishing the lung to arrest cough resolving phlegm and relieving asthma, heat clearing away
Reduce phlegm;For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.
Bulbus Lilii sweet and slightly bitter taste, property put down, enter the heart, lung meridian, have nourishing the lung to arrest cough, clearing away heart-fire for tranquillization it
Merit, after can be used for calentura, waste heat does not disappears, fidgets due to deficiency palpitation with fear, staring spells and pulmonary tuberculosis chronic cough, coughs up
The disease such as blood, lung abscess.
Radix Ophiopogonis, the micro-sugariness of property is bitter, cold, enters lung, stomach, heart channel;Can Yin-nourishing and body fluid promoting, lung moistening
Cough-relieving, clear away heart-fire relieving restlessness, cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat, cough,
Pulmonary tuberculosis.
Radix Scrophulariae sweet in the mouth, hardship, salty;Cold nature;Return lung, stomach, kidney channel;Can clearing away heat and cooling blood,
Eliminating fire and detoxication, YIN nourishing, control pathogenic warmth and join the army, cave in pericardium, maculae caused by violent heat pathogen, consumption of YIN caused by febrile disease,
Crimson tongue excessive thirst, Tianjin hinder constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle
Sore.
Radix Ginseng is flat, sweet in the mouth, micro-hardship, and tepor returns spleen, lung meridian, heart channel, can big complement
Gas, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, Fructus Alpiniae Oxyphyllae of calming the nerves;Control impairment caused by overstrain deficient, food
Less, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma rushs, spontaneous perspiration sudden collapse, are palpitated with fear, are good for
Forget, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency not
Multiple, the disease of all qi-blood-body fluid deficiencies.
Radix Adenophorae (Radix Glehniae) is sweet light, and property is put down, clearing away heat and nourishing YIN, and nourishing the lung to arrest cough cures mainly tracheitis, pertussis,
Cough due to lung-heat, coughs up phlegm yellow thick.
Radix Codonopsis taste sweet in the mouth, property is put down;Return spleen, lung meridian;Matter profit gas and, there is strengthening the spleen and tonifying the lung,
The effect that benefiting QI and nourishing blood promotes the production of body fluid;Curing mainly weakness of the spleen and stomach, anorexia and loose stool, fatigue and weakness, the deficiency of the lung is breathed heavily
Cough, lazy speech of breathing hard, spontaneous perspiration, blood deficiency and yellow complexion, thirsty.
Radix Scrophulariae bitter in the mouth is salty, and cold nature is nontoxic;Can removing heat from blood YIN nourishing, eliminating fire and detoxication, treatment send out
Burn excessive thirst, spontaneous sweating, constipation, haematemesis nose bleeding, pharyngolaryngitis, pulmonary tuberculosis.
Fructus Aristolochiae bitter in the mouth, cold nature, return lung, large intestine channel, can lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma,
Bowel relieving disappears hemorrhoid.For dyspnea and cough due to lung-heat, sputum mixed with blood, the hot hemorrhoidal bleeding of intestinal, swelling and pain of hemorrhoid.
The Cortex Eucommiae, Gan Weixin, temperature, enter lung meridian;Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Controlling spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination itches, and vaginal bleeding during pregnancy is intended to fall, and fetal movement is not
Peace, hypertension.
The acid of Folium Eriobotryae sweet in the mouth, property are put down;Core: bitter in the mouth, property are flat, enter lung, stomach warp;Treatment lung-heat
Cough with asthma, tells inverse, excessive thirst, and chronic cough is not healed, lung-dryness syndrome due to deficiency of YIN, spitting of blood;Deficiency of stomach-Yin, dry pharynx
Thirsty, QI failing to descend, the disease such as retch loss of appetite.
Radix Ophiopogonis gas delicate fragrance, hardship lightly seasoned, micro-, return lung, stomach, the heart, large intestine channel.There is heat clearing away solution
Poison, dispelling wind and heat pathogens, the effect of the pharynx profit diaphragm that disappears, drops blood pathogenic fire reducing, in eliminating pathogenic heat from blood to cure dysentery.Temperature can be controlled
Sick heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
Fructus Schisandrae Chinensis sweet in the mouth, acid, warm in nature;Return lung, the heart, kidney channel;Energy supplementing QI for promoting the production of body fluid, the kidney invigorating
Nourish heart, restrain astringent or styptic treatment for spontaneous sweating, can astringe the lung, nourishing kidney, promote the production of body fluid, receive antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough,
Xerostomia is made thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
Maltose sweet in the mouth, warm in nature;Return spleen channel, stomach warp, lung meridian;Can slow in, qi-restoratives, promote the production of body fluid,
Moisturize, cure mainly overstrain impairing the spleen, pain in the abdomen stomachache, xeropulmonary cough, haematemesis, thirsty, pharyngalgia,
Constipation.
Semen Armeniacae Amarum bitter in the mouth, slightly warm in nature, return lung, large intestine channel;Can sending down the abnormal ascending QI relieving cough and asthma, intestine moistening lead to
Just;For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.
Further, the primarily serving the purpose of of above-mentioned adding ingredient:
Crystal sugar sweet in the mouth, property is put down, nontoxic, enters spleen, lung two warp;Invigorating the spleen and replenishing QI, stomach function regulating lung moistening,
Cough-relieving is coughed, and reduce phlegm saliva;The property of medicine of other medical material can be relaxed and regulate simultaneously.
Pulp-water sweet in the mouth acidity is cool, can just not hinder by heat-clearing and toxic substances removing, stomach function regulating in tune, changes stagnation thirsty,
Stopping vomiting is vomited, dysentery of getting ill from overeating, excessive thirst;Strengthen human body medicine is digested and assimilated.Join medicine
In compositions, it is possible to auxiliary improves drug effect.
The described a kind of Chinese medicine composition treating consumptive lung disease of offer is provided
Preparation method, comprise the following steps:
The first step, weighs the Rhizoma Anemarrhenae, Semen Raphani, Radix Stephaniae Tetrandrae, Radix Asteris, Radix Asparagi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Roripa
Li, Cortex Mori, Semen Coicis, Bulbus Fritillariae Cirrhosae, Bulbus Lilii, Radix Ophiopogonis, Radix Scrophulariae, Radix Ginseng, Radix Adenophorae (Radix Glehniae), Radix Codonopsis,
Radix Scrophulariae, Fructus Aristolochiae, the Cortex Eucommiae, Folium Eriobotryae, Radix Ophiopogonis, Fructus Schisandrae Chinensis co-grinding are used after crossing 20 mesh sieves
Ethanol extraction, filters, and extracting solution is standby;
Second step, the extracting solution first step obtained, being dried to obtain relative density is 1.35~1.40
Thick paste;
3rd step, pulverizes, by Semen Armeniacae Amarum, crystal sugar, the thick paste prepared in same maltose, pulp-water and (2)
Through being dried after mixing, add adjuvant, pelletize, make required dosage form.
Further, in the first step, the described mixed extraction of the medical material weighed on request
Mode is: medicinal material mixture add 8~the 40 of 14 times~50% ethanol the condition of 85~100 DEG C
Lower extraction 9~12 hours.
Further, in second step, described dry mode is concentrating under reduced pressure or normal pressure height
Temperature concentrates.
Further, in the third step, described Semen Armeniacae Amarum, the pulverization conditions of crystal sugar are: pulverize
Rear mistake 100 mesh sieve.
Further, in the third step, the mode that described thick paste is dried is: vacuum drying,
Or vacuum lyophilization, or constant-pressure and high-temperature is dried.
Further, in the third step, the dosage form of described pharmaceutical composition is granule, ball
Agent, soft capsule.
The invention have the advantage that
A kind of pharmaceutical composition treating consumptive lung disease disclosed by the invention is pure Chinese medicinal preparation, at Gu
Revise on the basis of side, make curative effect rapider so that it is drug-specific rises for consumptive lung disease symptom
Effect, plays effect for the treatment of consumptive lung disease, prescription science, evident in efficacy, make without any poison is secondary
With, add pulp-water and crystal sugar, regulate and improve the absorbability of patient, and then improve medicine
Effect;The preparation method of pharmaceutical composition is simple, processing cost is low, the medicine efficacy of a drug of preparation is strong,
Instant effect, can eliminate rapidly consumptive lung disease symptom, uses modern crafts pharmacy, conveniently takes.
Detailed description of the invention
The specific embodiment of the present invention given below, is used for making the present invention the most specifically
Bright.
Experimental technique in following embodiment, if no special instructions, is conventional method.Under
State in embodiment medicinal raw material used, reagent material etc., if no special instructions, be city
Sell purchase product.
Embodiment 1
A kind of pharmaceutical composition treating consumptive lung disease
Crude drug forms: (unit: g)
The Rhizoma Anemarrhenae 300, Semen Raphani 200, Radix Stephaniae Tetrandrae 200, Radix Asteris 700, Radix Asparagi 100, the Pseudobulbus Bletillae (Rhizoma Bletillae)
100, Semen Lepidii 800, Cortex Mori 100, Semen Coicis 100, Bulbus Fritillariae Cirrhosae 200, Bulbus Lilii 100, Radix Ophiopogonis 300,
Radix Scrophulariae 200, Radix Ginseng 100, Radix Adenophorae (Radix Glehniae) 100, Radix Codonopsis 100, Radix Scrophulariae 100, Fructus Aristolochiae 100, Du
Secondary 300, Folium Eriobotryae 300, Fructus Schisandrae Chinensis 100, Radix Ophiopogonis 100, Semen Armeniacae Amarum 300, maltose 700, crystal sugar
300, pulp-water 700.
It is prepared via a method which:
(1) weigh on request the Rhizoma Anemarrhenae, Semen Raphani, Radix Stephaniae Tetrandrae, Radix Asteris, Radix Asparagi, the Pseudobulbus Bletillae (Rhizoma Bletillae),
Semen Lepidii, Cortex Mori, Semen Coicis, Bulbus Fritillariae Cirrhosae, Bulbus Lilii, Radix Ophiopogonis, Radix Scrophulariae, Radix Ginseng, Radix Adenophorae (Radix Glehniae), Radix Codonopsis,
Radix Scrophulariae, Fructus Aristolochiae, the Cortex Eucommiae, Folium Eriobotryae, Radix Ophiopogonis, Fructus Schisandrae Chinensis co-grinding add after crossing 20 mesh sieves
The ethanol of the 40% of 53.6kg extracts 12 hours under conditions of 100 DEG C, filters, and filtrate is standby
With.
(2) extracting solution that (1) is obtained pressure be 48kPa, temperature be the bar of 65 DEG C
Under part, it is condensed into the thick paste that relative density is 1.35.
(3) by Semen Armeniacae Amarum, crystal sugar through pulverizing, 100 mesh sieves are crossed.
(4) Semen Armeniacae Amarum after pulverizing, crystal sugar, pulp-water mix with the thick paste in maltose and (2)
Close uniformly under conditions of normal pressure 70 DEG C after forced air drying through micronizing, obtain particle diameter little
Pharmaceutical composition powder 9340g in 25 μm;According to drug powder: the ratio of starch=5:2
Example adds starch 3736g, mix homogeneously, pelletizes, makes granule, subpackage, every bag of 4g,
There are granule 3269 bags.
Embodiment 2
A kind of pharmaceutical composition treating consumptive lung disease
Crude drug forms: (unit: g)
The Rhizoma Anemarrhenae 500, Semen Raphani 400, Radix Stephaniae Tetrandrae 400, Radix Asteris 1000, Radix Asparagi 300, the Pseudobulbus Bletillae (Rhizoma Bletillae)
300, Semen Lepidii 1000, Cortex Mori 300, Semen Coicis 300, Bulbus Fritillariae Cirrhosae 500, Bulbus Lilii 300, Radix Ophiopogonis 600,
Radix Scrophulariae 500, Radix Ginseng 300, Radix Adenophorae (Radix Glehniae) 300, Radix Codonopsis 300, Radix Scrophulariae 300, Fructus Aristolochiae 300, Du
Secondary 600, Folium Eriobotryae 600, Fructus Schisandrae Chinensis 300, Radix Ophiopogonis 300, Semen Armeniacae Amarum 500, maltose 1000, crystal sugar
500, pulp-water 1000..
It is prepared via a method which:
(1) weigh on request the Rhizoma Anemarrhenae, Semen Raphani, Radix Stephaniae Tetrandrae, Radix Asteris, Radix Asparagi, the Pseudobulbus Bletillae (Rhizoma Bletillae),
Semen Lepidii, Cortex Mori, Semen Coicis, Bulbus Fritillariae Cirrhosae, Bulbus Lilii, Radix Ophiopogonis, Radix Scrophulariae, Radix Ginseng, Radix Adenophorae (Radix Glehniae), Radix Codonopsis,
Radix Scrophulariae, Fructus Aristolochiae, the Cortex Eucommiae, Folium Eriobotryae, Radix Ophiopogonis, Fructus Schisandrae Chinensis co-grinding add after crossing 20 mesh sieves
The ethanol of the 50% of 135.8kg extracts 9 hours under conditions of 85 DEG C, filters, and filtrate is standby.
(2) extracting solution (1) obtained is at normal pressure, under conditions of temperature is 95 DEG C, dense
Shorten the thick paste that relative density is 1.40 into.
(3) by Semen Armeniacae Amarum, crystal sugar through pulverizing, 100 mesh sieves are crossed.
(4) Semen Armeniacae Amarum after pulverizing, crystal sugar, pulp-water mix with the thick paste in maltose and (2)
Close uniformly under conditions of normal pressure 98 DEG C after forced air drying through micronizing, obtain particle diameter little
In the pharmaceutical composition powder 3680g of 25 μm, prepare every through molding, molding, capping
The pill of 10g 368.
Embodiment 3
A kind of pharmaceutical composition treating consumptive lung disease
Crude drug forms: (unit: kg)
The Rhizoma Anemarrhenae 5, Semen Raphani 4, Radix Stephaniae Tetrandrae 3, Radix Asteris 7, Radix Asparagi 2, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1, Semen Lepidii 10,
Cortex Mori 1, Semen Coicis 2, Bulbus Fritillariae Cirrhosae 3, Bulbus Lilii 3, Radix Ophiopogonis 4, Radix Scrophulariae 5, Radix Ginseng 2, Radix Adenophorae (Radix Glehniae) 1, party
Ginseng 1, Radix Scrophulariae 1, Fructus Aristolochiae 1, the Cortex Eucommiae 4, Folium Eriobotryae 5, Fructus Schisandrae Chinensis 2, Radix Ophiopogonis 2, maltose 9,
Semen Armeniacae Amarum 4, crystal sugar 3, pulp-water 8.
It is prepared via a method which:
(1) weigh on request the Rhizoma Anemarrhenae, Semen Raphani, Radix Stephaniae Tetrandrae, Radix Asteris, Radix Asparagi, the Pseudobulbus Bletillae (Rhizoma Bletillae),
Semen Lepidii, Cortex Mori, Semen Coicis, Bulbus Fritillariae Cirrhosae, Bulbus Lilii, Radix Ophiopogonis, Radix Scrophulariae, Radix Ginseng, Radix Adenophorae (Radix Glehniae), Radix Codonopsis,
Radix Scrophulariae, Fructus Aristolochiae, the Cortex Eucommiae, Folium Eriobotryae, Radix Ophiopogonis, Fructus Schisandrae Chinensis co-grinding add after crossing 20 mesh sieves
The ethanol of the 45% of 690kg extracts 10 hours under conditions of 90 DEG C, filters, and filtrate is standby.
(2) extracting solution (1) obtained is at normal pressure, under conditions of temperature is 97 DEG C, dense
Shorten the thick paste that relative density is 1.38 into.
(3) by Semen Armeniacae Amarum, crystal sugar through pulverizing, 100 mesh sieves are crossed.
(4) Semen Armeniacae Amarum after pulverizing, crystal sugar, pulp-water mix with the thick paste in maltose and (2)
Close uniformly drying chamber pressure be 48kPa, under conditions of temperature is 65 DEG C, drying time is 7h
Under conditions of thick paste is dried process;After through micronizing, obtain particle diameter less than 25
The pharmaceutical composition powder 26kg of μm.
(5) in (4), addition Cera Flava, hydrogenated palm oil, soybean phospholipid are sufficiently stirred for,
Mix homogeneously, stands, evacuation, treats that in medicinal liquid, bubble is removed substantially, with the glue changed
Hydraulic pressure ball, every dress 400mg compacting, there are soft capsule 100000.
Embodiment 4
A kind of pharmaceutical composition treating consumptive lung disease
Crude drug forms: (unit: kg)
The Rhizoma Anemarrhenae 4.5, Semen Raphani 3.5, Radix Stephaniae Tetrandrae 3.5, Radix Asteris 8, Radix Asparagi 2, the Pseudobulbus Bletillae (Rhizoma Bletillae) 2, Semen Lepidii
9, Cortex Mori 2, Semen Coicis 2, Bulbus Fritillariae Cirrhosae 3.5, Bulbus Lilii 2, Radix Ophiopogonis 4.5, Radix Scrophulariae 3.5, Radix Ginseng 2, sand
Ginseng 2, Radix Codonopsis 2, Radix Scrophulariae 2, Fructus Aristolochiae 2, the Cortex Eucommiae 4.5, Folium Eriobotryae 4.5, Fructus Schisandrae Chinensis 2, Radix Ophiopogonis
2, Semen Armeniacae Amarum 4, maltose 8.5, crystal sugar 4, pulp-water 8.5.
It is prepared via a method which:
(1) weigh on request the Rhizoma Anemarrhenae, Semen Raphani, Radix Stephaniae Tetrandrae, Radix Asteris, Radix Asparagi, the Pseudobulbus Bletillae (Rhizoma Bletillae),
Semen Lepidii, Cortex Mori, Semen Coicis, Bulbus Fritillariae Cirrhosae, Bulbus Lilii, Radix Ophiopogonis, Radix Scrophulariae, Radix Ginseng, Radix Adenophorae (Radix Glehniae), Radix Codonopsis,
Radix Scrophulariae, Fructus Aristolochiae, the Cortex Eucommiae, Folium Eriobotryae, Radix Ophiopogonis, Fructus Schisandrae Chinensis co-grinding add after crossing 20 mesh sieves
The ethanol of the 47% of 876kg extracts 11 hours under conditions of 95 DEG C, filters, and filtrate is standby.
(2) extracting solution that (1) is obtained pressure be 50kPa, temperature be the bar of 70 DEG C
Under part, it is condensed into the thick paste that relative density is 1.36.
(3) by Semen Armeniacae Amarum, crystal sugar through pulverizing, 100 mesh sieves are crossed.
(4) Semen Armeniacae Amarum after pulverizing, crystal sugar, pulp-water mix with the thick paste in maltose and (2)
Close uniformly at drying chamber pressure 110Pa, temperature of heating plate 38 DEG C, pre-freezing temperature-48 DEG C, freeze
Knot time 6.5h;Sublimation drying mode is for be directly set as 42 DEG C by shelf temperature, in cold-trap
Portion's circulation pipe temperature is set as-47 DEG C, and drying time is to do filtrate freezing under conditions of 5h
Dry process;After through micronizing, obtain the particle diameter pharmaceutical composition powder less than 25 μm
27.5kg。
(5) in (4) Chinese medicine composition powder, 80% appropriate amount of ethanol is added, after mixing thoroughly
Dry 2 hours with the temperature of 70 DEG C, pelletize, dry 1 hour with the temperature of 75 DEG C, after drying by medicine
Powder mixture powder, through the encapsulated process of granulator, every encapsulated 400mg, obtains capsule
68750.
Experimental example 1
The animal acute toxicity test of the Chinese medicine composition of the present invention
The present embodiment 2 mensuration by Mouse oral administration medicine median lethal dose(LD 50), investigates
The Chinese medicine composition of embodiment 2 preparation is to the acute toxic reaction of mice and death condition.
Take mice 30, often group 10, divide 3 groups, the most high, medium and low 3 dosage groups (0.8,
0.4,0.2ml/15g) gastric infusion 3 times/day, it was predicted that the scope of Calculating Median Lethal Dose of Drugs.Knot
Fruit display, high dose group does not measures median lethal dose(LD 50), therefore by medicine gastric infusion median lethal
The mensuration of amount changes the mensuration doing maximum volume purgation maximum lane point maximum tolerated dose.
Take mice 30, on an empty stomach after 12 hours, with the selected 0.8ml/15g metering of prediction by
Gastric infusion is to animal subject 3 times/day, Continuous Observation 7 days.
Giving by test product 24 hours in gavage, mice voluntary activity declines, and ingests, takes the photograph water and subtract
Few;Within second day, voluntary activity gradually tends to normal, stool, urine no abnormality seen, and mice lives
Dynamic, food ration, body weight growths, feces etc. are all normal, observe the rear test mice that expires whole
Survival.
Observe and put to death whole test mice gross necropsy after expiring, find each important organ, as
The heart, liver, spleen, lung, kidney, ovary, intestinal, stomach etc. change without obvious pathomorphism.
The maximum dosage-feeding result of the test of medicine gastric infusion shows: 30 mices are equal after being administered
Without obvious toxic reaction, also without dead in one week.Record to after mouse stomach administration medicine
Maximum tolerated dose is 39.2g/kg d, as become human oral dosage form 8.0g/60kg to calculate by clinic,
Then the mice of this medicine gavage maximum tolerated dose on the one is clinical adult oral dose on the one
[(39.2g/kg) ÷ (8.0g/60kg) ≈ 294] times.Chinese medicine composition of the present invention is described
The safety of thing is good.
Experimental example 2
The human trial of a kind of pharmaceutical composition treating consumptive lung disease of the present invention
Clinical data
One, general data: this Chinese medicine composition is applied to clinical observation case 120 example, man
70 examples, female 50 example.Age 30~70 years old.Cardinal symptom is cough, and spue thick expectorant foam,
Or with cold and heat, emaciated physique, lethargy, cardiopalmus asthma, xerocheilia, pulse condition is empty
The diseases such as number.
Two, usage and dosage: during clinical practice, the component in compositions according to the body weight of patient,
Age and symptom take the circumstances into consideration increase and decrease.This Chinese medicine composition embodiment 1 medicine one day one bag.Take medicine
Period less salt, low fat diet, wine of banning on opium-smoking and the opium trade, medication 15 days is 1 course for the treatment of.
Three, criterion of therapeutical effect:
(1) effective: clinical symptoms and sign disappear substantially, life can be taken care of oneself;
(2) effective: a sings and symptoms part takes a turn for the better;
(3) invalid: sings and symptoms is all not improved, symptom is the most front.
Four, therapeutic outcome (see table 1):
Table 1 therapeutic outcome
By Drug therapy consumptive lung disease patient 120 example of the present invention, treat 1 course for the treatment of, the most effective
92 examples, effective 10 examples, invalid 18 examples, obvious effective rate is 76.7%, and effective percentage is 8.33%,
Total effective rate is 85%.
These are only the preferred embodiments of the present invention and experimental example, be not limited to this
Invention, for a person skilled in the art, the present invention can have various modifications and variations.
All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement made
Deng, should be included within the scope of the present invention.
Claims (8)
1. the pharmaceutical composition treating consumptive lung disease, it is characterised in that including: the Rhizoma Anemarrhenae, Radix Raphani
Son, Radix Stephaniae Tetrandrae, Radix Asteris, Radix Asparagi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Lepidii, Cortex Mori, Semen Coicis, Bulbus Fritillariae Cirrhosae,
Bulbus Lilii, Radix Ophiopogonis, Radix Scrophulariae, Radix Ginseng, Radix Adenophorae (Radix Glehniae), Radix Codonopsis, Radix Scrophulariae, Fructus Aristolochiae, the Cortex Eucommiae,
Folium Eriobotryae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Semen Armeniacae Amarum, maltose, pulp-water, its weight portion consists of:
The Rhizoma Anemarrhenae 3~6 parts, Semen Raphani 2~5 parts, Radix Stephaniae Tetrandrae 2~5 parts, Radix Asteris 6~10 parts, Tianmen
Winter 1~3 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1~3 parts, Semen Lepidii 8~10 parts, Cortex Mori 1~3 parts, Semen Coicis 1~3
Part, Bulbus Fritillariae Cirrhosae 2~5 parts, Bulbus Lilii 1~3 parts, Radix Ophiopogonis 3~6 parts, Radix Scrophulariae 2~5 parts, Radix Ginseng
1~3 part, Radix Adenophorae (Radix Glehniae) 1~3 parts, Radix Codonopsis 1~3 parts, Radix Scrophulariae 1~3 parts, Fructus Aristolochiae 1~3 parts,
The Cortex Eucommiae 3~6 parts, Folium Eriobotryae 3~6 parts, Fructus Schisandrae Chinensis 1~3 parts, Radix Ophiopogonis 1~3 parts, maltose
7~10 parts, Semen Armeniacae Amarum 3~5 parts, pulp-water 7~10 parts.
Pharmaceutical composition the most according to claim 1, it is characterised in that also include: ice
Sugar 3~5 parts.
Pharmaceutical composition the most according to claim 2, it is characterised in that its drug regimen
Thing weight portion consists of: the Rhizoma Anemarrhenae 5 parts, Semen Raphani 4 parts, Radix Stephaniae Tetrandrae 3 parts, Radix Asteris 7 parts,
Radix Asparagi 2 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1 part, Semen Lepidii 10 parts, Cortex Mori 1 part, Semen Coicis 2 parts, Bulbus Fritillariae Cirrhosae
3 parts, Bulbus Lilii 3 parts, Radix Ophiopogonis 4 parts, Radix Scrophulariae 5 parts, Radix Ginseng 2 parts, Radix Adenophorae (Radix Glehniae) 1 part,
Radix Codonopsis 1 part, Radix Scrophulariae 1 part, Fructus Aristolochiae 1 part, the Cortex Eucommiae 4 parts, Folium Eriobotryae 5 parts, the five tastes
Son 2 parts, Radix Ophiopogonis 2 parts, maltose 9 parts, 4 parts of Semen Armeniacae Amarum, 3 parts of crystal sugar, pulp-water 8 parts.
4. the preparation method of a pharmaceutical composition as claimed in claim 2, it is characterised in that
Preparation method is as follows:
The first step, weigh the Rhizoma Anemarrhenae 3~6 parts, Semen Raphani 2~5 parts, Radix Stephaniae Tetrandrae 2~5 parts,
Radix Asteris 6~10 parts, Radix Asparagi 1~3 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1~3 parts, Semen Lepidii 8~10 parts, Cortex Mori
1~3 part, Semen Coicis 1~3 parts, Bulbus Fritillariae Cirrhosae 2~5 parts, Bulbus Lilii 1~3 parts, Radix Ophiopogonis 3~6 parts,
Radix Scrophulariae 2~5 parts, Radix Ginseng 1~3 parts, Radix Adenophorae (Radix Glehniae) 1~3 parts, Radix Codonopsis 1~3 parts, Radix Scrophulariae 1~3
Part, Fructus Aristolochiae 1~3 parts, the Cortex Eucommiae 3~6 parts, Folium Eriobotryae 3~6 parts, Fructus Schisandrae Chinensis 1~3 parts,
Radix Ophiopogonis 1~3 parts, co-grinding exists with the ethanol of 8~14 times 40~50% after crossing 20 mesh sieves
Extracting 9~12 hours under conditions of 85~100 DEG C, filter, extracting solution is standby;
Second step, the extracting solution first step obtained, be dried to obtain thick paste;
3rd step, weigh Semen Armeniacae Amarum 3~5 parts, crystal sugar 3~5 parts, with maltose 7~10 after pulverizing
Part, after the thick paste mixing for preparing in pulp-water 7~10 parts and second step through being dried, add
Add adjuvant, pelletize, make granule, or pill, or soft capsule, or capsule.
Preparation method the most according to claim 4, it is characterised in that in second step,
Described dry mode is concentrating under reduced pressure, or constant-pressure and high-temperature concentrates.
Preparation method the most according to claim 4, it is characterised in that in second step,
The relative density of described thick paste is 1.35~1.40.
Preparation method the most according to claim 3, it is characterised in that in the third step,
Described Semen Armeniacae Amarum, the pulverization conditions of crystal sugar be: crosses 100 mesh sieves after pulverizing.
Preparation method the most according to claim 3, it is characterised in that in the third step,
The mode that described thick paste is dried is: vacuum drying, or vacuum lyophilization, or normal pressure
High temperature drying.
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Citations (4)
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CN1712059A (en) * | 2005-05-23 | 2005-12-28 | 刘胜全 | Chinese medicine for treatig cavernous tuberculosis |
CN101352546A (en) * | 2008-08-26 | 2009-01-28 | 荣玉明 | Chinese medicine for treating lung cyst, pulmonary fibrosis and suppressing cough and preparation method thereof |
CN102988729A (en) * | 2012-10-29 | 2013-03-27 | 严中明 | Chinese medicine composition for treating pneumonia |
CN104998137A (en) * | 2015-07-24 | 2015-10-28 | 侯志廷 | Traditional Chinese medicine composite for treating lung diseases |
-
2016
- 2016-06-23 CN CN201610485348.3A patent/CN105943951A/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1712059A (en) * | 2005-05-23 | 2005-12-28 | 刘胜全 | Chinese medicine for treatig cavernous tuberculosis |
CN101352546A (en) * | 2008-08-26 | 2009-01-28 | 荣玉明 | Chinese medicine for treating lung cyst, pulmonary fibrosis and suppressing cough and preparation method thereof |
CN102988729A (en) * | 2012-10-29 | 2013-03-27 | 严中明 | Chinese medicine composition for treating pneumonia |
CN104998137A (en) * | 2015-07-24 | 2015-10-28 | 侯志廷 | Traditional Chinese medicine composite for treating lung diseases |
Non-Patent Citations (1)
Title |
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潘卫中等: "保和汤加味治疗咳嗽50例", 《实用中医内科杂志》 * |
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