CN105943599B - A kind of Lingnan features Chinese medicine composition and its preparation with bowel relaxing functions containing hypericum japonicum - Google Patents
A kind of Lingnan features Chinese medicine composition and its preparation with bowel relaxing functions containing hypericum japonicum Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of Lingnan features Chinese medicine composition and its preparation with bowel relaxing functions containing hypericum japonicum, is formulated: hypericum japonicum: phoenix-tail fern: Chinese mesona herb: creeping oxalis=4:(1.8-2.2 by the Lingnan features Chinese medicine of following weight ratio): (1.8-2.2): (0.8-1.2).The present invention has the effect of clearing heat and promoting diuresis, relax bowel and defecation, removing toxic substances laxation, and therapeutic effect is good, securely and reliably, and uses Lingnan features Chinese medicine, raw material is easy to get.
Description
Technical field
The present invention relates to field of medicaments, specially a kind of Lingnan features Chinese medicine group with bowel relaxing functions containing hypericum japonicum
Close object and its preparation.
Background technique
Constipation is clinical common complicated symptom, rather than a kind of disease, is primarily referred to as defecation frequency reduction, excrement amount subtracts
Less, excrement is dry and hard, defecation is laborious etc..Must in conjunction with excrement character, I usually whether there is or not difficulties to make for bowl evacuation habit and defecation
Whether there is or not the judgements of constipation.It was such as chronic constipation more than 6 months.Constipation often shows themselves in that awareness of defecation is few, and bowel frequency is also few；Defecation is difficult,
Arduously；Defecation is unsmooth；Dry and hard excrement, it is hard just, the not clean sense of defecation；Constipation is with abdominal pain or abdominal discomfort.Some patientss also with
The Behavioral disturbances such as insomnia, agitation, dreaminess, depression and anxiety.
Illness rate of the constipation in crowd is up to 27%, can influence the people of each age group.Women is more than male, old more
Yu Qing, the prime of life.Because constipation disease incidence is high, the cause of disease is complicated, patient often has manifold vexations, and will affect quality of life when constipation is serious.
The drug for treating constipation currently on the market is mostly irritant purgative (containing rheum officinale, folium sennae, phenolphthalein etc.), these drugs
It is more strong, it is unsuitable for being used for a long time, it is reversible after drug withdrawal, or even aggravate constipation.Therefore, using south of the Five Ridges natural resources of Chinese medicinal materials abundant,
The Chinese medicine composition for developing healthy effective relax bowel and defecation has important value.
Summary of the invention
The purpose of the present invention is to provide a kind of Lingnan features Chinese medicine composition with bowel relaxing functions containing hypericum japonicum,
Its curative effect is obvious and pharmacological property is mild.
To achieve the goals above, the present invention adopts the following technical scheme: a kind of have bowel relaxing functions containing hypericum japonicum
Lingnan features Chinese medicine composition, be formulated by the Lingnan features Chinese medicine of following weight ratio: hypericum japonicum: phoenix-tail fern: bean jelly
Grass: creeping oxalis=4:(1.8-2.2): (1.8-2.2): (0.8-1.2).
Preferably, it is formulated by the Lingnan features Chinese medicine of following weight ratio: hypericum japonicum: phoenix-tail fern: Chinese mesona herb: jealous woman slurry
Grass=4:(1.9-2.1): (1.9-2.1): (0.9-1.1).
It is furthermore preferred that being formulated by the Lingnan features Chinese medicine of following weight ratio: hypericum japonicum: phoenix-tail fern: Chinese mesona herb: jealous woman
Starch grass=4:2:2:1.
The Chinese medicine composition is decoction.
A kind of Lingnan features Chinese materia medica preparation with bowel relaxing functions containing hypericum japonicum, is with the Traditional Chinese medicine composition formula
The extract of middle component is effective component, adds preparation made from pharmaceutic adjuvant.
The dosage form of the preparation is tablet, capsule, granule, oral solution or pill.
The extract is water extract.
Lingnan features Chinese medicine composition provided by the invention has the effect of clearing heat and promoting diuresis, relax bowel and defecation, removing toxic substances laxation,
Therapeutic effect is good, securely and reliably, and uses Lingnan features Chinese medicine, raw material is easy to get.
Specific embodiment
The present invention is a kind of Lingnan features Chinese medicine composition with bowel relaxing functions containing hypericum japonicum, by following weight ratio
Lingnan features Chinese medicine be formulated: hypericum japonicum: phoenix-tail fern: Chinese mesona herb: creeping oxalis=4:(1.8-2.2): (1.8-2.2):
(0.8-1.2).Preferably, it is formulated by the Lingnan features Chinese medicine of following weight ratio: hypericum japonicum: phoenix-tail fern: Chinese mesona herb: jealous woman
Starch grass=4:(1.9-2.1): (1.9-2.1): (0.9-1.1).It is furthermore preferred that being matched by the Lingnan features Chinese medicine of following weight ratio
It makes: hypericum japonicum: phoenix-tail fern: Chinese mesona herb: creeping oxalis=4:2:2:1.
In Lingnan features Chinese medicine used in the present invention:
Hypericum japonicum expels the heat-evil by the stasis of blood, dampness removing promoting in side, is monarch drug in a prescription；The clear large intestine of phoenix-tail fern, creeping oxalis control two just, are minister
Medicine；Chinese mesona herb is sweet light cool, seeps diuresis and to rush down kidney turbid, is adjutant the benefits of to help defaecation.
Hypericum japonicum: for the herb of Garcinia maingayii hypericum japonicum Hypericum japonicum Thunb..Sweet, slight bitter, it is cool.
Return lung, liver, stomach meridian.With clearing heat and promoting diuresis, the effect of removing toxic substances, eliminating stasis to subdue swelling.Modern pharmacological studies have shown that hypericum japonicum has excitement
Smooth muscle effect: to isolated rabbit intestines, there are spastic receipts in the visible Rythmic contractions characteristic enhancing of hypericum japonicum liquid extract low concentration, high concentration
Contracting.
Phoenix-tail fern: for the herb of Pteridaceae plant phoenix-tail fern Pteris multifida Poir..Light, slight bitter, it is cool.Enter
Liver, kidney, large intestine channel.With clearing heat and promoting diuresis, the effect of cooling blood and hemostasis, subdhing swelling and detoxicating.Phoenix-tail fern is also recorded in " Guangxi medicine plants will "
Have effects that " clear large intestine ".
Chinese mesona herb: for the herb of Lamiaceae plant Chinese mesona herb Mesona chinensis Benth..It is sweet, light, it is cool.Have
It relieves summer heat, the effect of heat-clearing, cool blood, removing toxic substances.
Creeping oxalis: for the herb of oxalidaceae plant creeping oxalis Oxalis corniculata L..Acid is cool.Return large intestine,
Small intestinl channel.With clearing heat and promoting diuresis, the effect of removing toxicity for detumescence.Creeping oxalis is recorded in " plucking member side " is used for " controlling constipation and anuresis ".
Lingnan features Chinese medicine composition of the present invention can be in health food or drug of the preparation with bowel relaxing functions
In application.The dosage form of health food or drug is decoction, or with the extract of component in the Traditional Chinese medicine composition formula
For effective component, preparation made from pharmaceutic adjuvant is added, dosage form can be tablet, capsule, granule, oral solution or pill
Deng.Component extract is preferably water extract in formula, is made using general extraction process by water.
Below with reference to embodiment, the present invention is further illustrated, but the present invention is not limited thereto specific examples.
Embodiment 1
Hypericum japonicum 120g, phoenix-tail fern 60g, Chinese mesona herb 60g, creeping oxalis 30g are taken, 12 times of amount water are added, is impregnated 30 minutes, reflux
It extracts 1.5 hours, extracts 2 times, filtering, merging filtrate is concentrated to 250ml, obtains decoction.
Embodiment 2
Hypericum japonicum 120g, phoenix-tail fern 65g, Chinese mesona herb 65g, creeping oxalis 25g are taken, 10 times of amount water are added, is impregnated 45 minutes, reflux
It extracts 2 hours, extracts 3 times, filtering, merging filtrate is concentrated to 250ml, obtains decoction.
Embodiment 3
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 17.6g is taken, fine powder is ground into, is added
Entering suitable medical starch and superfine silica gel powder, mix, crosses 14 meshes and pelletize, 65 DEG C of dryings carry out whole grain after 14 meshes,
Then suitable magnesium stearate is added, mixes, is pressed into 100 to get tablet.Every slice weight 0.3g.
Embodiment 4
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 12.0g is taken, fine powder is ground into, with
Suitable calcium monohydrogen phosphate, microcrystalline cellulose, Sucralose, crospovidone and sodium carboxymethyl starch, mix, and 3% povidone is molten
Liquid is adhesive, crosses 14 meshes and pelletizes, and 65 DEG C of dryings carry out whole grain after 14 meshes, suitable stearic acid is then added
Magnesium is pressed into 100 to get dispersible tablet.Every 0.5g of dispersible tablet.
Embodiment 5
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 15.4g is taken, fine powder is ground into, is added
Enter suitable medical starch and magnesium stearate, be uniformly mixed, sieving is packed into capsule, is made 100 to get hard capsule.Every intragranular
Tolerant heavy 0.2g.
Embodiment 6
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 10.5g is taken, is added suitable third
Glycol, lecithin and soybean oil vibromill ultra micro 20 minutes, make to mix, and are made soft capsule 100 to get soft capsule.Every contains
Content 0.3g.
Embodiment 7
1 gained decoction of above-described embodiment is taken, is concentrated, it is dry, obtain dry extract；Dry extract 16.8g is taken, fine powder is ground into, is added
Enter suitable dextrin and lactose, mix, granulation, 65 DEG C of dryings, cross 14 meshes carry out whole grain, packing, be made 100 packet to get
Granula.Every packet weight 5g.
Embodiment 8
1 gained decoction of above-described embodiment is taken, appropriate amount of purified water is added, agitating and heating is boiled, boiled 20 minutes, to be cooled to arrive
At 30~40 DEG C, appropriate chitosan and potassium sorbate is added, be stirred to dissolve uniformly, filtering, finally plus pure water adjust to
1000ml is filtered, and packing sterilizes to get oral solution.Every oral solution 10ml.(defecation of Constipation Model mouse is real for experimental example
It tests)
1 material
1.1 animals: SPF grades of KM mouse, male, 20-25g, 32 [it is provided by Nanfang Medical Univ's Experimental Animal Center,
Animal certificate number: SCXK (Guangdong) 2011-2015].
1.2 reagents: (ratio that the present invention is formulated in embodiment 1 takes hypericum japonicum 78g, phoenix-tail fern 39g, Chinese mesona herb to tested material
39g, creeping oxalis 19.5g add 12 times of amount water, impregnate 30 minutes, refluxing extraction 1.5 hours, extract 2 times, filtering, merging filtrate,
It is concentrated to 50ml, contains crude drug 3.51g/ml), and hemp seed soft capsule (Tianjin Central Pharmaceutical Co., Ltd, lot number: 150702), and salt
Sour Loperamide capsule (Xian-Janssen Pharmaceutical Ltd., lot number: 151217062), sodium carboxymethylcellulose, prepared Chinese ink
2 methods
Mouse 32 are taken, blank control group, Constipation Model group, hemp seed soft capsule group, administration group of the present invention are randomly divided into.It is empty
White control group and Constipation Model group stomach-filling distilled water, remaining corresponding medical fluid of each group stomach-filling, stomach-filling volume be 10mL/kg, daily one
It is secondary, continuous 3d, ad lib during experiment.
After the last administration, each group mouse is deprived of food but not water 12h.Each group stomach-filling loperamide hydrochloride in addition to blank control group
(3.0mg/kg), the distilled water of blank control group stomach-filling same volume.After stomach-filling loperamide hydrochloride 30min, each administration group difference
Contain the drug of prepared Chinese ink suspension (2% prepared Chinese ink 100mL+1g sodium carboxymethylcellulose) corresponding dosage, blank by 10mL/kg stomach-filling
Control group and Constipation Model group mouse press 10mL/kg stomach-filling prepared Chinese ink suspension.Every mouse is individually raised, and free water is ingested.
Since stomach-filling prepared Chinese ink, observe and record every mouse arrange melena for the first time the time required to, defecation grain number and stool weight in 6h.
3 results
Compared with Constipation Model group, the present invention can be shortened Constipation Model mouse and arrange for the first time the melena time (P < 0.05), increase
6h defecation grain number (P < 0.05) and stool weight.Illustrate that the present invention has bowel relaxing functions.It is shown in Table 1.
Table 1 to Constipation Model mouse defecation influence (N=8)
Compared with blank control group, * P < 0.05, * * P < 0.01；Compared with model group, #P < 0.05, ##P < 0.01
Claims (7)
1. a kind of Lingnan features Chinese medicine composition with bowel relaxing functions containing hypericum japonicum, by the Lingnan features of following weight ratio
Chinese medicine is formulated: hypericum japonicum: phoenix-tail fern: Chinese mesona herb: creeping oxalis=4:(1.8-2.2): (1.8-2.2): (0.8-1.2).
2. the Lingnan features Chinese medicine composition with bowel relaxing functions according to claim 1 containing hypericum japonicum, feature
It is: is formulated by the Lingnan features Chinese medicine of following weight ratio: hypericum japonicum: phoenix-tail fern: Chinese mesona herb: creeping oxalis=4:
(1.9-2.1):(1.9-2.1):(0.9-1.1)。
3. the Lingnan features Chinese medicine composition with bowel relaxing functions according to claim 1 containing hypericum japonicum, feature
It is: is formulated by the Lingnan features Chinese medicine of following weight ratio: hypericum japonicum: phoenix-tail fern: Chinese mesona herb: creeping oxalis=4:2:2:
1。
4. the Lingnan features Chinese medicine composition with bowel relaxing functions according to claim 1,2 or 3 containing hypericum japonicum,
Be characterized in that: the Chinese medicine composition is decoction.
5. a kind of Lingnan features Chinese materia medica preparation with bowel relaxing functions containing hypericum japonicum, it is characterised in that be with claim 1,
The extract of component is effective component in 2 or 3 Traditional Chinese medicine composition formulas, adds preparation made from pharmaceutic adjuvant.
6. the Lingnan features Chinese materia medica preparation with bowel relaxing functions according to claim 5 containing hypericum japonicum, feature exist
In: the dosage form of the preparation is decoction, tablet, capsule, granule, oral solution or pill.
7. the Lingnan features Chinese materia medica preparation with bowel relaxing functions according to claim 5 containing hypericum japonicum, feature exist
In: the extract is water extract.
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