CN105941425A - {0><}0{>Sterilization composition containing fluoride ether bacteria amide and oxadixyl and application of sterilization composition<0} - Google Patents

{0><}0{>Sterilization composition containing fluoride ether bacteria amide and oxadixyl and application of sterilization composition<0} Download PDF

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CN105941425A
CN105941425A CN201610365078.2A CN201610365078A CN105941425A CN 105941425 A CN105941425 A CN 105941425A CN 201610365078 A CN201610365078 A CN 201610365078A CN 105941425 A CN105941425 A CN 105941425A
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wakil
bacterium amide
ether bacterium
fluorine ether
bactericidal composition
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CN105941425B (en
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石振龙
万维肖
郭崇友
赵东亚
程清云
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Nanjing Huazhou Pharmaceutical Co Ltd
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Nanjing Huazhou Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/761,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

{0><}0{>The invention discloses a sterilization composition containing fluoride ether bacteria amide and oxadixyl and application of the sterilization composition. <0}{0><}0{>The sterilization composition takes the fluoride ether bacteria amide and the oxadixyl as main effective ingredients, and the mass ratio of the fluoride ether bacteria amide to the oxadixyl is (1 to 70) : (1 to 50). <0}{0><}0{>The sterilization composition can be applied to prevention and treatment of diseases of cereals, fruit trees and vegetables, has a relatively high synergistic effect, is capable of overcoming and retarding the drug resistance of pathogenic bacteria, is high in sterilization speed and long in lasting period, is capable of lowering the application cost, and achieves a prevention and treatment effect obviously superior to that of the single fluoride ether bacteria amide or oxadixyl. <0}{0><}0{>The sterilization composition can be used for preventing and treating fungi diseases of crops, especially can be used for preventing and treating fungi diseases such as downy mildew of grape, potato blight, rice sheath blight disease, downy mildew of cucumber and epidemic disease, and achieves an effect obviously superior to that of the single fluoride ether bacteria amide or oxadixyl.

Description

A kind of fluorine-containing ether bacterium amide and the bactericidal composition of Wakil and application thereof
Technical field:
The present invention relates to a kind of bactericidal composition and application thereof, especially one is main with fluorine ether bacterium amide and Wakil The bactericidal composition of active component and application thereof.
Background technology
Fluorine ether bacterium amide molecule formula: C15H8ClF7N2O2, chemical name: N-(3-chloro-5-(trichloromethyl) pyridine-2-first Base)-2,3,5,6-four chloro-4-methoxy benzamide.Structural formula is as follows:
Fluorine ether bacterium amide acts on the respiratory chain of fungal mitochondria, the activity of suppression succinate dehydrogenase, thus blocks electricity Son transmission, suppress fungus spore germination, germ tube extend, mycelial growth and spore mother cell formed fungus growth and breeding main In the stage, bactericidal action is directly caused by parent active agent, does not has corresponding metabolic activity, for downy mildew of garpe, Phytophthora capsici, The multiple fungal diseases such as the late blight of potato, rice sheath blight disease, cotton seedling blight all have higher preventive effect, are that one is novel extensively Spectrum antibacterial.
Wakil (Oxadixyl), molecular formula: C14H18N2O4, chemical name: 2-methoxyl group-N-(2-oxo-1,3-azoles Alkane-3-' yl) acetyl amine-n-(2 ', 6 '-dimethyl benzene).Wakil is a kind of systemic fungicide, soil sterilants, the most again It it is a plant growth regulators.The mechanism of action is unique, efficiently, low toxicity, nuisanceless, pathogenic fungi can be suppressed mycelial normally Grow or directly kill pathogenic bacteria, plant growing can be promoted again.To soil fungi, Fusarium spp., root shell bacterium, rhizoctonia, pythium spp, Seedling The rotten pathogen such as bacterium, photovoltaicing leather bacteria has significant prevention effect, to damping-off, seedling rot, damping off, droop, verticillium wilt, bacterium Core disease, anthrax, epidemic disease, dry rot, scab, sclerotium soft rot, seedling blight, stem wilt, leaf blight, macerate root, continuous cropping continuous cropping Obstacle has specially good effect.
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, along with the change of pattern of farming, melon fruits and vegetables etc. Industrial crops cultivated area progressively expands, and disease occurrence degree, generation quantity all increase, and in preventing and treating, difficulty strengthens;Separately On the one hand, the resistance of pathogen rises under lasting medicament selection pressure year by year, and the prevention effect of single dose is had a greatly reduced quality, plant Disease control is faced with significant challenge.
Summary of the invention:
It is an object of the invention to provide a kind of applied widely, low cost, effective fluorine-containing for above-mentioned technical problem Ether bacterium amide and the plant bactericidal composition of Wakil.
It is a still further object of the present invention to provide this bactericidal composition and cause answering on fungal disease at preventing and treating plant epiphyte With, especially preventing and treating the fungal diseases such as downy mildew of garpe, the late blight of potato, rice sheath blight disease, cucumber downy mildew and epidemic disease On purposes.
It is an object of the invention to be achieved through the following technical solutions:
A kind of fluorine-containing ether bacterium amide and the bactericidal composition of Wakil, this bactericidal composition is with fluorine ether bacterium amide and Wakil For principle active component, wherein fluorine ether bacterium amide is 1~70:1~50 with the mass ratio of Wakil, wherein has in bactericidal composition Effective constituent is present in compositions with enhancing effective amount.
Described bactericidal composition, wherein fluorine ether bacterium amide is preferably 1~70:1~20 with the mass ratio of Wakil, enters one Step is preferably 1~10:1~20, the most preferably 1~10:10~20.The preferred mass of fluorine ether bacterium amide and Wakil is joined Ratio can also be: 70:1,50:1,30:1,20:1,10:1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:30, 1:50.
In the compositions of the present invention, account for both fluorine ether bacterium amide and Wakil the weight/mass percentage composition of compositions be 2~ 80%.Preferably 5~70%.
Described bactericidal composition, wherein with fluorine ether bacterium amide and Wakil for principle active component and known auxiliary agent and Excipient is re-dubbed on pesticide any one dosage form allowed.Known to these, auxiliary agent, excipient have dispersant, diffusant, disappear Infusion, wetting agent, disintegrating agent etc., can use calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, benzylphenol polyoxyethylene Ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether and similar products thereof, aliphatic amine polyoxyethylene ether, fatty acid ring Oxidative ethane addition product, polyoxyethylene polyoxy propylene block compound, castor oil polyoxyethylene ether, NPE, tell Temperature series, fatty alcohol-polyoxyethylene ether, Polyethylene Glycol series, Sulfonates, carboxylate, sulfate, phosphate, phosphite, One or more combinations in lignosulfonates, xanthan gum, phenol formaldehyde condensate, ammonium salt, quaternary etc., excipient includes Ketohexamethylene, dimethylbenzene, various solvent naphtha, water, antifreezing agent (such as propylene glycol), deionized water etc..Above auxiliary agent, excipient and other Adjuvant can be alone or and use.
Described bactericidal composition, its dosage form is cream, wettable powder, suspending agent, aqueous emulsion or water dispersion granule.
The application on preparation preventing and treating fungal diseases of plants medicine of the above-mentioned bactericidal composition.Especially preventing and treating cereal Application in terms of class, fruit tree, vegetable crop disease has significant effect.
Above-mentioned application, described fungal diseases of plants is downy mildew of garpe, the late blight of potato, rice sheath blight disease, Huang At least one in melon downy mildew and epidemic disease.
The feature of bactericidal composition of the present invention:
1, the fluorine ether bacterium amide used by the present invention and Wakil, the mechanism of action is different, and mutual mixture will not produce low touching, can Synergistic, reduces dosage, reduces cost.
2, the present composition scope of application increases, it is adaptable to preventing and treating Cereal, fruit tree, the refractory fungal disease of vegetable, Particularly prevent and treat downy mildew of garpe, the late blight of potato, rice sheath blight disease, cucumber downy mildew and epidemic disease etc. and all have significantly effect Really.Bactericidal composition of the present invention has good prevention effect to ascomycetes, basidiomycetes, Fungi Imperfecti and Oomycete fungal disease; And suppress the drug-fast generation to unitary agent (fluorine ether bacterium amide and Wakil are arbitrary) of insect or fungus or antibacterial.The present invention Bactericidal composition can produce higher synergistic function, and the consumption of the independent reactive compound of amount ratio of this mixture is big Big reduction, i.e. the activity of mixture is more than the activity of independent component.
Compared with prior art beneficial effects of the present invention: (1), compared with single dose, said composition antagonism fungal disease is such as The fungal diseases such as downy mildew of garpe, the late blight of potato, rice sheath blight disease, cucumber downy mildew and epidemic disease have obvious Synergistic to make With, overcoming and delayed Drug resistance, expanding prevention is composed, hence it is evident that improve prevention effect;(2) preventing and treating recruitment, drug cost are reduced; (3) alternative routine and the pesticide being easily generated resistance;(4) compared with single dose, produce and use cost reduces;(5) suppression fungus Drug-fast generation, its effect uses apparently higher than its single dose.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of dosage form is routine side Method, " % " of the present invention is mass percent.
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure the different agents EC to bacterial strain50Value, uses co-toxicity coefficient calculating side Method, calculates the co-toxicity coefficient (CTC) of mixture, determines the building performance of mixture, and circular is as follows:
In mixture, a certain single dose (is generally selected EC as standard agent50Junior), calculate:
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
Toxicity index × A single dose toxicity index of proportion+B single dose in mixture of theoretical toxicity index=A single dose × B single dose proportion in mixture
The EC of actual measurement toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theory toxicity index × 100
When co-toxicity coefficient classification: CTC is more than 120, mixture has synergetic, is antagonism when CTC is less than 80, and CTC exists It it is summation action between 80-120.
According to effective ingredient fluorine ether bacterium amide (A): Wakil (B) quality proportioning is: 80:1,70:1,50:1,30:1,20: 1,10:1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:30,1:50,1:60,1:70 test, and measure it Co-toxicity coefficient to cucumber downy mildew (Pseudoperonospora cubensis (Berk.et Curt.) Rostov.).
Table 1: fluorine ether bacterium amide+Wakil different ratio indoor biometrics result to cucumber downy mildew
Medicament Virulence regression equation EC50(mg/L) Co-toxicity coefficient
50% fluorine ether bacterium amide WP Y=3.050X+3.295 3.622 -
25% Wakil WP Y=1.647X+3.836 5.089 -
A:B=80:1 Y=1.235X+4.061 5.758 88.70
A:B=70:1 Y=2.085X+3.940 3.224 158.49
A:B=50:1 Y=2.136X+3.966 3.049 167.85
A:B=30:1 Y=1.117X+4.312 4.129 124.40
A:B=20:1 Y=2.068X+3.806 3.778 136.59
A:B=10:1 Y=2.554X+3.669 3.320 157.40
A:B=5:1 Y=3.639X+3.188 3.147 169.86
A:B=2.5:1 Y=1.426X+4.296 3.118 177.88
A:B=1:1 Y=2.067X+3.927 3.303 180.02
A:B=1:2 Y=1.456X+4.108 4.101 153.63
A:B=1:4 Y=3.201X+2.786 4.918 134.48
A:B=1:6 Y=2.524X+3.275 4.826 140.05
A:B=1:10 Y=3.323X+2.978 4.060 169.86
A:B=1:20 Y=1.045X+4.368 4.022 174.42
A:B=1:30 Y=2.789X+2.939 5.481 128.76
A:B=1:50 Y=2.134X+3.504 5.026 141.14
A:B=1:60 Y=1.549X+3.717 6.733 105.50
A:B=1:70 Y=2.445X+3.061 6.211 117.46
Field control effectiveness test:
The pesticidal preparations preventing and treating cucumber downy mildew test prepared with above-described embodiment.
1, test processes: this test medicine consumption sets three concentration for the treatment of respectively according to the difference of each composition, compares medicine Agent is pesticide single dose 50% fluorine ether bacterium amide WP and 25% Wakil WP and blank clean water experiment respectively.
2, each plot area of test method is 66.7m2, it is repeated 3 times;Investigation drug effect side after investigating before dispenser and preventing and treating Method is: randomization 5 point in test treatment region, carries out severity Scaling according to country's field test relevant criterion, calculates preventive effect. Result of the test is shown in Table 2:
Table 2 field test effect
Being shown by indoor biometrics and field efficacy result, fluorine ether bacterium amide and Wakil compositions have the most collaborative Potentiation, the prevention effect of compositions is excellent, and prevention effect is all better than single dose kind, has application valency in agricultural is applied Value.
Two kinds of reactive compounds can be processed into any one dosage form of permission, illustrates two kinds with specific embodiment below The preparation that effective ingredient is processed into, but the preparation that these two kinds of active component can be processed is not limited only to set forth below.
Embodiment 1:15% fluorine ether bacterium amide Wakil wettable powder (1:2)
By fluorine ether bacterium amide 5g, Wakil 10g, detergent LS (to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, diffusion Agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, prepares effectively Ingredient percent is 15% fluorine ether bacterium amide Wakil wettable powder.
Embodiment 2:15% fluorine ether bacterium amide Wakil wettable powder (1:4)
By fluorine ether bacterium amide 3g, Wakil 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, kaolinite Soil adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient mass percent is that 15% fluorine ether bacterium amide Wakil can WP.
Embodiment 3:14% fluorine ether bacterium amide Wakil wettable powder (1:6)
By fluorine ether bacterium amide 2g, Wakil 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, kaolinite Soil adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient mass percent is that 14% fluorine ether bacterium amide Wakil can WP.
Embodiment 4:20% fluorine ether bacterium amide Wakil suspending agent (1:1)
Weigh 10g fluorine ether bacterium amide, 10g Wakil, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof, Xanthan gum 0.15g, ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill Making effective Ingredient percent is 20% fluorine ether bacterium amide Wakil suspending agent.
Embodiment 5:55% fluorine ether bacterium amide Wakil aqueous emulsion (1:10)
Weigh 5g fluorine ether bacterium amide, 50g Wakil, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl Phenol polyethenoxy ether 1g, 150# solvent naphtha 13g, adds water to 100g.The method that above raw material is prepared aqueous emulsion routinely puts into Mixing kettle high speed mixes, and making effective Ingredient percent is 55% fluorine ether bacterium amide Wakil aqueous emulsion.
Embodiment 6:42% fluorine ether bacterium amide Wakil cream (1:20)
Weigh 2g fluorine ether bacterium amide, 40g Wakil, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, 150# solvent naphtha is to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, makes effective ingredient Mass percent is 42% fluorine ether bacterium amide Wakil cream.
Embodiment 7:70% fluorine ether bacterium amide Wakil cream (2.5:1)
Weigh 50g fluorine ether bacterium amide, 20g Wakil, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, Castor oil polyoxyethylene ether 2g, 150# solvent naphtha is to 100g.The method that above raw material is prepared cream routinely puts into mixing kettle Middle mixing, making effective Ingredient percent is 70% fluorine ether bacterium amide Wakil cream.
Embodiment 8:18% fluorine ether bacterium amide Wakil water dispersion granule (5:1)
Weigh 15g fluorine ether bacterium amide, 3g Wakil, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, gather Vinyl alcohol 5g, Borax 2g, kieselguhr complements to 100g, is formed with imitating composition quality by water dispersible granular agent method by above raw material Percentage ratio is 17% fluorine ether bacterium amide Wakil water dispersion granule.
Embodiment 9:11% fluorine ether bacterium amide Wakil cream (10:1)
Weigh 10g fluorine ether bacterium amide, 1g Wakil, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, 150# solvent naphtha is to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, makes effective ingredient Mass percent is 11% fluorine ether bacterium amide Wakil cream.
Embodiment 10:31.5% fluorine ether bacterium amide Wakil microemulsion (20:1)
Weigh 30g fluorine ether bacterium amide, 1.5g Wakil, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphorus Acid esters 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.Above raw material is prepared routinely The method of microemulsion puts in mixing kettle and mixes, and making effective Ingredient percent is 31.5% fluorine ether bacterium amide Wakil Microemulsion.
Embodiment 11:31% fluorine ether bacterium amide Wakil cream (30:1)
Weigh 30g fluorine ether bacterium amide, 1g Wakil, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, 150# solvent naphtha is to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, makes effective ingredient Mass percent is 31% fluorine ether bacterium amide Wakil cream.
Embodiment 12:51% fluorine ether bacterium amide Wakil suspending agent (50:1)
Weigh 50g fluorine ether bacterium amide, 1g Wakil, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof, Huang Virgin rubber 0.15g, ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, makes under the effect of sand mill Becoming effective ingredient mass percent is 51% fluorine ether bacterium amide Wakil suspending agent.
Embodiment 13:32% fluorine ether bacterium amide Wakil microemulsion (1:15)
Weigh 2g fluorine ether bacterium amide, 30g Wakil, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphoric acid Ester 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.Above raw material is prepared micro-routinely The method of Emulsion puts in mixing kettle and mixes, and making effective Ingredient percent is 32% fluorine ether bacterium amide Wakil microemulsion Agent.
Embodiment 14:6% fluorine ether bacterium amide Wakil aqueous emulsion (1:5)
Weigh 1g fluorine ether bacterium amide, 5g Wakil, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol Polyoxyethylene ether 1g, 150# solvent naphtha 13g, adds water to 100g.The method that above raw material is prepared aqueous emulsion routinely puts into mixed Closing the mixing of still high speed, making effective Ingredient percent is 6% fluorine ether bacterium amide Wakil aqueous emulsion.
Embodiment 15:62% fluorine ether bacterium amide Wakil microemulsion (1:30)
Weigh 2g fluorine ether bacterium amide, 60g Wakil, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphoric acid Ester 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.Above raw material is prepared micro-routinely The method of Emulsion puts in mixing kettle and mixes, and making effective Ingredient percent is 62% fluorine ether bacterium amide Wakil microemulsion Agent.
Embodiment 16:51% fluorine ether bacterium amide Wakil suspending agent (1:50)
Weigh 1g fluorine ether bacterium amide, 50g Wakil, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof, Huang Virgin rubber 0.15g, ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, makes under the effect of sand mill Becoming effective ingredient mass percent is 51% fluorine ether bacterium amide Wakil suspending agent.
Embodiment 17:7% fluorine ether bacterium amide Wakil water dispersion granule (1:2.5)
Weigh 2g fluorine ether bacterium amide, 5g Wakil, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, poly-second Enol 5g, Borax 2g, white carbon 3g, kieselguhr complement to 100g, by water dispersible granular agent method, above raw material are formed with effect Ingredient percent is 7% fluorine ether bacterium amide Wakil water dispersion granule.

Claims (10)

1. a fluorine-containing ether bacterium amide and the bactericidal composition of Wakil, it is characterised in that this bactericidal composition is with fluorine ether bacterium amide Being principle active component with Wakil, wherein fluorine ether bacterium amide is 1~70:1~50 with the mass ratio of Wakil.
Bactericidal composition the most according to claim 1, it is characterised in that described fluorine ether bacterium amide and the mass ratio of Wakil It is 1~70:1~20.
Bactericidal composition the most according to claim 2, it is characterised in that described fluorine ether bacterium amide and the mass ratio of Wakil It is 1~10:1~20.
Bactericidal composition the most according to claim 3, it is characterised in that described fluorine ether bacterium amide and the mass ratio of Wakil It is 1~10:10~20.
Bactericidal composition the most according to claim 1, it is characterised in that both described fluorine ether bacterium amide and Wakil account for The weight/mass percentage composition of compositions is 2-80%.
Bactericidal composition the most according to claim 5, it is characterised in that both described fluorine ether bacterium amide and Wakil account for The weight/mass percentage composition of compositions is 5-70%.
Bactericidal composition the most according to claim 1, it is characterised in that with fluorine ether bacterium amide and Wakil for main effectively Composition and insecticides adjuvant, excipient are configured on pesticide any one dosage form allowed.
Bactericidal composition the most according to claim 7, it is characterised in that described dosage form be cream, suspending agent, aqueous emulsion, Wettable powder or water dispersion granule.
9. the application on preparation preventing and treating fungal diseases of plants medicine of the bactericidal composition described in claim 1.
Application the most according to claim 9, it is characterised in that described fungal diseases of plants is downy mildew of garpe, Ma Ling At least one in potato late blight, rice sheath blight disease, cucumber downy mildew and epidemic disease.
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