CN105920184A - Externally applied Chinese medicinal composition for treating cervical spondylosis and preparation method thereof - Google Patents

Externally applied Chinese medicinal composition for treating cervical spondylosis and preparation method thereof Download PDF

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CN105920184A
CN105920184A CN201610384471.6A CN201610384471A CN105920184A CN 105920184 A CN105920184 A CN 105920184A CN 201610384471 A CN201610384471 A CN 201610384471A CN 105920184 A CN105920184 A CN 105920184A
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parts
radix
chinese medicine
medicine extract
cervical spondylosis
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郑笑遥
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract

The invention relates to a medicine and a preparation method of the medicine, in particular to an externally applied medicine for treating cervical spondylosis and a preparation method of the externally applied medicine for treating the cervical spondylosis. The Chinese medicinal composition comprises Chinese herbal extracts which are formed by processing the following Chinese medical herbs in parts by weight: 35 to 45 parts of puerarin, 25 to 35 parts of radix paeoniae alba, 25 to 35 parts of Zhichuanxue(a local Chinese medical herb), 8 to 12 parts of papaya, 8 to 12 parts of root of rehmannia, 8 to 12 parts of Zhimouda(a local Chinese medical herb), 8 to 12 parts of scorpion, 8 to 12 parts of cassia twig, 8 to 12 parts of jujube kernels, 8 to 12 parts of Zhiyiyou (a local Chinese medical herb), 8 to 12 parts of asarum, 8 to 12 parts of liquorice, 8 to 12 parts of Zhisancao (a local Chinese medical herb), 8 to 12 parts of notoginseng, 8 to 12 parts of tortoise shell, 8 to 12 parts of Zhiermu (a local Chinese medical herb), 8 to 12 parts of chrysanthemum, 8 to 12 parts of large-leaved gentian, 8 to 12 parts of safflower, 10 to 15 parts of notopterygium, 8 to 12 parts of divaricate saposhnikovia root, and 8 to 12 parts of clematis root. The externally applied Chinese medicinal composition for treating the cervical spondylosis disclosed by the invention has the beneficial effects of precise and appropriate compatibility of medicines, obvious effect in treating cervical spondylosis, no dependency for being externally applied, no harm to a body and good safety.

Description

Chinese medicine composition of external curing cervical spondylosis and preparation method thereof
Technical field
The present invention relates to a kind of medicine and preparation method thereof, more particularly to external curing cervical spondylosis medicine and Preparation method.
Background technology
Cervical spondylosis refers to that degeneration of cervical intervertebral disc, cervical vertebra plumpness hypertrophy and neck injury etc. cause cervical spinal canal or intervertebral Bore deformation, narrow, stimulate, oppress cervical spinal cord, nerve root, hyperosteogeny of cervical vertebra, or prolapse of intervertebral disc, ligament and thicken, stimulate Or compressing cervical spinal, cervical neural, blood vessel and produce the clinical syndrome of series of symptoms.With neck and shoulder pain, emit to headrest portion Or double lower limb spasm, difficulty in walking, even quadriplegia, defecation obstacle occur in upper limb, very severe one, paralysis occurs.Minority has Dizziness.At present, the therapeutic modality of cervical spondylosis is presented diversified feature, including Chinese and western drugs treatment, operative treatment, Minimally-invasive treatment, acupuncture and tuina-massage etc., but most relatively complicated.It is desirable to provide a kind of easy to use, absorption rate is high The Chinese medicine composition of external curing cervical spondylosis.
Summary of the invention
It is an object of the invention to solve the deficiencies in the prior art, it is provided that the Chinese medicine composition of a kind of external curing cervical spondylosis And preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is:
The Chinese medicine composition of external curing cervical spondylosis, described Chinese medicine composition includes Chinese medicine extract, described Chinese medicine extract by The Chinese herbal medicine of following weight portion processes: Radix Puerariae 35-45 part, Radix Paeoniae Alba 25-35 part, river processed snow 25-35 part, Fructus Chaenomelis 8-12 part, Radix Rehmanniae 8-12 part, system tries to gain big 8-12 part, Scorpio 8-12 part, Ramulus Cinnamomi 8-12 part, Semen Ziziphi Spinosae 8-12 part, second processed 8-12 part again, Herba Asari 8- 12 parts, Radix Glycyrrhizae 8-12 part, system three grass 8-12 part, Radix Notoginseng 8-12 part, Carapax et Plastrum Testudinis 8-12 part, system two wood 8-12 part, Flos Chrysanthemi 8-12 part, the Qin Macrophylla 8-12 part, Flos Carthami 8-12 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Saposhnikoviae 8-12 part, Radix Clematidis 8-12 part.
Preferably, described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Radix Puerariae 40 parts, the Radix Paeoniae Alba 30 parts, River processed avenges 30 parts, Fructus Chaenomelis 10 parts, 10 parts of the Radix Rehmanniae, and system tries to gain big 10 parts, Scorpio 10 parts, Ramulus Cinnamomi 10 parts, Semen Ziziphi Spinosae 10 parts, second processed again 10 Part, Herba Asari 10 parts, 10 parts of Radix Glycyrrhizae, system three grass 10 parts, Radix Notoginseng 10 parts, Carapax et Plastrum Testudinis 10 parts, 10 parts of system two wood, Flos Chrysanthemi 10 parts, Radix Gentianae Macrophyllae 10 Part, 10 parts of Flos Carthami, Rhizoma Et Radix Notopterygii 12 parts, Radix Saposhnikoviae 10 parts, Radix Clematidis 10 parts.
Preferably, described Chinese medicine composition also includes gel auxiliary agent, and dosage form is gel.
A kind of preparation method of the Chinese medicine composition of external curing cervical spondylosis, step is as follows:
A () prepares Chinese medicine extract: the Radix Puerariae of formula ratio, the Radix Paeoniae Alba, river processed snow, Fructus Chaenomelis, the Radix Rehmanniae, system are tried to gain greatly, Scorpio, Ramulus Cinnamomi, Fructus Jujubae Core, second processed again, Herba Asari, Radix Glycyrrhizae, system three grass, Radix Notoginseng, Carapax et Plastrum Testudinis, system two wood, Flos Chrysanthemi, Radix Gentianae Macrophyllae, Flos Carthami, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Radix Clematidis, add Entering the ethanol water of 200-250ml volume fraction 75-85%, in 90-110 DEG C of backflow extraction 2-3 hour, lixiviating solution was through vacuum Concentrate postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract helps toward gel Agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.2-0.8%, poloxamer 15-20%, and surplus is Deionized water；
The proportioning of Chinese medicine extract and gel auxiliary agent is: add 25-35g Chinese medicine extract in every 100-150ml gel auxiliary agent.
Rational choice of the present invention Radix Puerariae, the Radix Paeoniae Alba, river processed snow, Fructus Chaenomelis, the Radix Rehmanniae, system are tried to gain greatly, Scorpio, Ramulus Cinnamomi, Semen Ziziphi Spinosae, second processed Again, Herba Asari, Radix Glycyrrhizae, system three grass, Radix Notoginseng, Carapax et Plastrum Testudinis, system two wood, Flos Chrysanthemi, Radix Gentianae Macrophyllae, Flos Carthami, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Radix Clematidis, by extraction, Concentrate, lyophilization obtains dry powder, prevented from caking, and effective ingredient is difficult to oxidation deterioration, long shelf-life, with gel auxiliary agent in proportion It is mixed into gel, existing mixed existing use, keep high pharmaceutically active, be coated on cervical vertebra, be aided with massage, use the most square Just, owing in gel, lock aqueous is good, and the most volatile exsiccation, effective ingredient can the most slowly discharge, therapeutic effect Good.
The invention has the beneficial effects as follows: the Chinese medicine composition compatibility of the present invention is precise and appropriate, treatment cervical spondylosis effect is notable, this Bright Chinese medicine composition is medicine for external use, no dependence, and without compromising on health, safety is good.
Detailed description of the invention
Below by specific embodiment, technical scheme is described in further detail.
Embodiment 1:
External curing cervical spondylosis Chinese medicine composition gel, described Chinese medicine composition includes Chinese medicine extract and gel auxiliary agent, Described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Radix Puerariae 35 parts, the Radix Paeoniae Alba 25 parts, and river processed avenges 25 parts, Fructus Chaenomelis 8 Part, 8 parts of the Radix Rehmanniae, make and try to gain big 8 parts, Scorpio 8 parts, Ramulus Cinnamomi 8 parts, Semen Ziziphi Spinosae 8 parts, second processed 8 parts again, Herba Asari 8 parts, 8 parts of Radix Glycyrrhizae, system three grass 8 parts, Radix Notoginseng 8 parts, Carapax et Plastrum Testudinis 8 parts, 8 parts of system two wood, Flos Chrysanthemi 8 parts, Radix Gentianae Macrophyllae 8 parts, 8 parts of Flos Carthami, Rhizoma Et Radix Notopterygii 10 parts, Radix Saposhnikoviae 8 parts, Radix Clematidis 8 Part；
The step of its preparation method is as follows:
A () prepares Chinese medicine extract: the Radix Puerariae of formula ratio, the Radix Paeoniae Alba, river processed snow, Fructus Chaenomelis, the Radix Rehmanniae, system are tried to gain greatly, Scorpio, Ramulus Cinnamomi, Fructus Jujubae Core, second processed again, Herba Asari, Radix Glycyrrhizae, system three grass, Radix Notoginseng, Carapax et Plastrum Testudinis, system two wood, Flos Chrysanthemi, Radix Gentianae Macrophyllae, Flos Carthami, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Radix Clematidis, add Entering the ethanol water of 200ml volume fraction 75%, in 90 DEG C of backflow extractions 3 hours, lixiviating solution was freezing dry after being concentrated in vacuo Dry, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract becomes toward gel Type agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.2%, poloxamer 15%, and surplus is deionization Water；The proportioning of Chinese medicine extract and gel auxiliary agent is: add 25g Chinese medicine extract in every 100ml gel auxiliary agent.
Embodiment 2:
External curing cervical spondylosis Chinese medicine composition gel, described Chinese medicine composition includes Chinese medicine extract and gel auxiliary agent, Described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Radix Puerariae 45 parts, the Radix Paeoniae Alba 35 parts, and river processed avenges 35 parts, Fructus Chaenomelis 12 parts, 12 parts of the Radix Rehmanniae, make and try to gain big 12 parts, Scorpio 12 parts, Ramulus Cinnamomi 12 parts, Semen Ziziphi Spinosae 12 parts, second processed 12 parts again, Herba Asari 12 parts, Radix Glycyrrhizae 12 parts, system three grass 12 parts, Radix Notoginseng 12 parts, Carapax et Plastrum Testudinis 12 parts, 12 parts of system two wood, Flos Chrysanthemi 12 parts, Radix Gentianae Macrophyllae 12 parts, 12 parts of Flos Carthami, Rhizoma Et Radix Notopterygii 15 parts, Radix Saposhnikoviae 12 parts, Radix Clematidis 12 parts；
The step of its preparation method is as follows:
A () prepares Chinese medicine extract: the Radix Puerariae of formula ratio, the Radix Paeoniae Alba, river processed snow, Fructus Chaenomelis, the Radix Rehmanniae, system are tried to gain greatly, Scorpio, Ramulus Cinnamomi, Fructus Jujubae Core, second processed again, Herba Asari, Radix Glycyrrhizae, system three grass, Radix Notoginseng, Carapax et Plastrum Testudinis, system two wood, Flos Chrysanthemi, Radix Gentianae Macrophyllae, Flos Carthami, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Radix Clematidis, add Entering the ethanol water of 250ml volume fraction 85%, in 110 DEG C of backflow extractions 3 hours, lixiviating solution was freezing dry after being concentrated in vacuo Dry, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract becomes toward gel Type agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.8%, poloxamer 20%, and surplus is deionization Water；The proportioning of Chinese medicine extract and gel auxiliary agent is: add 35g Chinese medicine extract in every 150ml gel auxiliary agent.
Embodiment 3
External curing cervical spondylosis Chinese medicine composition gel, described Chinese medicine composition includes Chinese medicine extract and gel auxiliary agent, Described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Radix Puerariae 40 parts, the Radix Paeoniae Alba 30 parts, and river processed avenges 30 parts, Fructus Chaenomelis 10 parts, 10 parts of the Radix Rehmanniae, make and try to gain big 10 parts, Scorpio 10 parts, Ramulus Cinnamomi 10 parts, Semen Ziziphi Spinosae 10 parts, second processed 10 parts again, Herba Asari 10 parts, Radix Glycyrrhizae 10 parts, system three grass 10 parts, Radix Notoginseng 10 parts, Carapax et Plastrum Testudinis 10 parts, 10 parts of system two wood, Flos Chrysanthemi 10 parts, Radix Gentianae Macrophyllae 10 parts, 10 parts of Flos Carthami, Rhizoma Et Radix Notopterygii 12 parts, Radix Saposhnikoviae 10 parts, Radix Clematidis 10 parts；
The step of its preparation method is as follows:
A () prepares Chinese medicine extract: the Radix Puerariae of formula ratio, the Radix Paeoniae Alba, river processed snow, Fructus Chaenomelis, the Radix Rehmanniae, system are tried to gain greatly, Scorpio, Ramulus Cinnamomi, Fructus Jujubae Core, second processed again, Herba Asari, Radix Glycyrrhizae, system three grass, Radix Notoginseng, Carapax et Plastrum Testudinis, system two wood, Flos Chrysanthemi, Radix Gentianae Macrophyllae, Flos Carthami, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Radix Clematidis, add Entering the ethanol water of 220ml volume fraction 80%, in 100 DEG C of backflow extractions 2.5 hours, lixiviating solution was freezing after being concentrated in vacuo It is dried, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract becomes toward gel Type agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.5%, poloxamer 18%, and surplus is deionization Water；The proportioning of Chinese medicine extract and gel auxiliary agent is: add 30g Chinese medicine extract in every 130ml gel auxiliary agent.
The clinical trial of Chinese medicine composition of the present invention
Cervical spondylosis efficacy determination: with reference to State Administration of Traditional Chinese Medicine's " Chinese medical disease Standardization of diagnosis and curative effect " curative effect of formulating in 1994 Evaluation criteria.
Recovery from illness: symptom, the somatic feature scores such as pain, numbness or dizziness subtract >=95%, and x-ray shows normally；
Effective: symptom, the somatic feature scores such as pain, numbness or dizziness subtract >=70%, ＜ 95%, x-ray shows and is clearly better；
Effective: symptom, the somatic feature scores such as pain, numbness or dizziness subtract >=30%, ＜ 70%, and x-ray shows improvement；
Invalid: symptom, the somatic feature scores such as pain, numbness or dizziness subtract less than 30%, ＜ 70%, x-ray display is without changing.
Note: computing formula (nimodipine method) is ［ integration before (integration after integration-treatment before treatment) ÷ treatment ］ × 100%.
Treatment case and therapeutic effect statistics: according to above-mentioned regulation, use the Drug therapy Patients with Cervical Spondylopathy of the present invention 300 examples, wherein, male 150 examples, female 150 example；Age 25～60 years old；The course of disease one month～10 years.300 example treatment cases, at random It is divided into three groups, is respectively coated with the Chinese medicine composition of embodiment 1-3, three times a day, massages 30min, continuous use after coating every time Time is 60 days, and result is as follows:
Recovery from illness Effectively Invalid Total effective rate
Embodiment 1 50 30 20 80%
Embodiment 2 60 25 15 85%
Embodiment 3 75 20 5 95%
Described Chinese medicine composition reasonable recipe, full side plays blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, the merit of expelling wind and removing dampness altogether, uses in tradition Medical service law and modern pharmacy Transdermal absorption are theoretical, use Chinese medicine composition gel to stick and are aided with massage treatment, can make to be distributed in phase Subcutaneous nerve and the blood vessel of answering affected part are in a kind of excitatory state, and the ability of mass exchange is strengthened, and promotes the god of human body Warp, Humoral immunity effect and immunologic function, improve the functional activity of relevant organ, thus reach to treat the purpose of disease.
Embodiment described above is the one preferably scheme of the present invention, not makees the present invention any pro forma Limit, on the premise of without departing from the technical scheme described in claim, also have other variant and remodeling.

Claims (4)

1. the Chinese medicine composition of external curing cervical spondylosis, it is characterised in that: described Chinese medicine composition includes Chinese medicine extract, described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Radix Puerariae 35-45 part, Radix Paeoniae Alba 25-35 part, river processed snow 25-35 part, Fructus Chaenomelis 8-12 part, Radix Rehmanniae 8-12 part, system tries to gain big 8-12 part, Scorpio 8-12 part, Ramulus Cinnamomi 8-12 part, Semen Ziziphi Spinosae 8-12 part, second processed 8-again 12 parts, Herba Asari 8-12 part, Radix Glycyrrhizae 8-12 part, system three grass 8-12 part, Radix Notoginseng 8-12 part, Carapax et Plastrum Testudinis 8-12 part, system two wood 8-12 part, chrysanthemum Flower 8-12 part, Radix Gentianae Macrophyllae 8-12 part, Flos Carthami 8-12 part, Rhizoma Et Radix Notopterygii 10-15 part, Radix Saposhnikoviae 8-12 part, Radix Clematidis 8-12 part.
The Chinese medicine composition of external curing cervical spondylosis the most according to claim 1, it is characterised in that: described Chinese medicine extract Being processed by the Chinese herbal medicine of following weight portion: Radix Puerariae 40 parts, the Radix Paeoniae Alba 30 parts, river processed avenges 30 parts, Fructus Chaenomelis 10 parts, 10 parts of the Radix Rehmanniae, System tries to gain big 10 parts, Scorpio 10 parts, Ramulus Cinnamomi 10 parts, Semen Ziziphi Spinosae 10 parts, second processed 10 parts again, Herba Asari 10 parts, and 10 parts of Radix Glycyrrhizae makes three grass 10 Part, Radix Notoginseng 10 parts, Carapax et Plastrum Testudinis 10 parts, 10 parts of system two wood, Flos Chrysanthemi 10 parts, Radix Gentianae Macrophyllae 10 parts, 10 parts of Flos Carthami, Rhizoma Et Radix Notopterygii 12 parts, Radix Saposhnikoviae 10 parts, Radix Clematidis 10 parts.
The Chinese medicine composition of external curing cervical spondylosis the most according to claim 1 and 2, it is characterised in that: described Chinese drug-treated group Compound also includes gel auxiliary agent, and dosage form is gel.
4. the preparation method of the Chinese medicine composition of the external curing cervical spondylosis described in a claim 3, it is characterised in that: step As follows:
A () prepares Chinese medicine extract: the Radix Puerariae of formula ratio, the Radix Paeoniae Alba, river processed snow, Fructus Chaenomelis, the Radix Rehmanniae, system are tried to gain greatly, Scorpio, Ramulus Cinnamomi, Fructus Jujubae Core, second processed again, Herba Asari, Radix Glycyrrhizae, system three grass, Radix Notoginseng, Carapax et Plastrum Testudinis, system two wood, Flos Chrysanthemi, Radix Gentianae Macrophyllae, Flos Carthami, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae and Radix Clematidis, add Entering the ethanol water of 200-250ml volume fraction 75-85%, in 90-110 DEG C of backflow extraction 2-3 hour, lixiviating solution was through vacuum Concentrate postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel auxiliary agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, then Micro-filtration goes the removal of impurity, encapsulation；
C () Chinese medicine extract and gel auxiliary agent are with suitable ratio mix homogeneously, hybrid mode is that Chinese medicine extract helps toward gel Agent is added, stirring while adding；
In described gel auxiliary agent, the mass fraction of each component is as follows: hyaluronic acid 0.2-0.8%, poloxamer 15-20%, and surplus is Deionized water；
The proportioning of Chinese medicine extract and gel auxiliary agent is: add 25-35g Chinese medicine extract in every 100-150ml gel auxiliary agent.
CN201610384471.6A 2016-06-02 2016-06-02 Externally applied Chinese medicinal composition for treating cervical spondylosis and preparation method thereof Withdrawn CN105920184A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104623516A (en) * 2013-11-11 2015-05-20 魏德胜 Traditional Chinese medicine composition for treating cervical spondylosis
CN105056144A (en) * 2015-08-28 2015-11-18 张文学 Chinese herb composition for treating cervical spondylosis

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104623516A (en) * 2013-11-11 2015-05-20 魏德胜 Traditional Chinese medicine composition for treating cervical spondylosis
CN105056144A (en) * 2015-08-28 2015-11-18 张文学 Chinese herb composition for treating cervical spondylosis

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