CN105920176A - 一种治疗急性泪囊炎的中药散剂及制备方法 - Google Patents
一种治疗急性泪囊炎的中药散剂及制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗急性泪囊炎的中药散剂及制备方法,该中药散剂取下述重量配比的中药原料制备而成:鱼腥草20‑30份、山大颜15‑25份、柽柳15‑25份、千里光10‑20份、夏枯草10‑20份、黄柏10‑20份、蕨萁5‑15份、八角莲5‑15份、白茎鸦葱5‑15份、白芷5‑15份、草藤乌2‑8份、地梭罗2‑8份。本发明治疗急性泪囊炎的中药散剂,采用常见中药材作为原料,制备简单,疗效显著,使用方便,无副作用,具有祛风清热、解毒排脓、祛瘀消肿的功效,可有效治疗急性泪囊炎。
Description
技术领域
本发明涉及中医中药领域,特别是涉及一种治疗急性泪囊炎的中药散剂及制备方法。
背景技术
泪囊炎是由于鼻泪管阻塞、泪囊内泪液和分泌物潴留并进而遭致细菌感染所引起的泪道疾病,一般表现为慢性和急性两种。急性泪囊炎大多在慢性泪囊炎的基础上发生,与侵入细菌的毒力强大或机体抵抗力降低有关,或因泪囊部外伤、泪道探通等损伤泪囊壁,致病菌感染扩散到泪囊周围组织所致。致病菌以金黄色葡萄球菌或淋病双球菌常见。感染途径可由眼睑、结膜、眼眶或面部的化脓性炎症直接扩散,远处化脓性病灶转移或来源于全身感染。该症泪囊局部组织表现为急性蜂窝织炎、充血、肿胀、发热剧疼,重者可引起上下睑及鼻梁部肿胀,结膜充血水肿、流泪加剧,继则形成脓肿,可有波动,若穿破皮肤则形成瘘管。炎症消退后通过瘘管,脓液由筛或鼻腔排出。另外还会出现全身发烧、血像增高,头痛,下颌淋巴结及耳前淋巴结肿大,压痛等不适。
西医对急性泪囊炎治疗方法为及时使用抗生素控制感染,病情严重者,全身应用广谱抗生素,有瘘管者需手术切除。然而抗生素具有较大的毒副作用,手术治疗对身体有较大的伤害,患者接受较为困难。急性泪囊炎相当于中医的“漏睛疮”,是因心经蕴热,复感风邪,风热上攻,客于泪窍,结疮成脓;或素食辛辣,心脾热毒蕴结目窍,热盛肉腐,为脓为漏。在现有的专利文件中,申请公告号CN103948865A(申请号201410179723.2)的中国专利文献公开了一种治疗急性泪囊炎的中药汤剂及制备方法,本发明取下述重量配比的主要原料制备而成:金银花25-40份,连翘6-15份,蒲公英8-16份,紫花地丁9-15份,败酱草10-16份,酒大黄3-9份,芒硝5-12份,生薏米15-25份,滑石12-25份,炮山甲4-9份,生甘草6-15份,皂刺5-10份,郁金6-15份,枳壳3-9份,杭芍6-15份。
虽然中药在治疗急性泪囊炎方面有一定的疗效,但是现存的技术中的口服中药服用不方便,起效慢,疗效不显著。
发明内容
本发明的目的之一是克服现有技术的不足,提供一种制备简单,疗效显著,使用方便、无副作用的治疗急性泪囊炎的中药散剂。
为了解决上述技术问题,本发明所采用的技术方案是:
一种治疗急性泪囊炎的中药散剂,取下述重量配比的中药原料制备而成:鱼腥草20-30份、山大颜15-25份、柽柳15-25份、千里光10-20份、夏枯草10-20份、黄柏10-20份、蕨萁5-15份、八角莲5-15份、白茎鸦葱5-15份、白芷5-15份、草藤乌2-8份、地梭罗2-8份。
一种治疗急性泪囊炎的中药散剂,优选的方案,取下述重量配比的中药原料制备而成:鱼腥草23-27份、山大颜18-22份、柽柳18-22份、千里光13-17份、夏枯草13-17份、黄柏13-17份、蕨萁8-12份、八角莲8-12份、白茎鸦葱8-12份、白芷8-12份、草藤乌4-6份、地梭罗4-6份。
一种治疗急性泪囊炎的中药散剂,更加优选的方案,取下述重量配比的中药原料制备而成:鱼腥草25份、山大颜20份、柽柳20份、千里光15份、夏枯草15份、黄柏15份、蕨萁10份、八角莲10份、白茎鸦葱10份、白芷10份、草藤乌5份、地梭罗5份。
本发明的另一目的是提供上述治疗急性泪囊炎的中药散剂的制备方法。
一种治疗急性泪囊炎的中药散剂的制备方法,步骤如下:
步骤一:将鱼腥草、千里光、夏枯草、白茎鸦葱、草藤乌洗净、除杂后,置于砂锅内,加原料重量8倍的水浸泡40-60分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮25-35min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮15-25min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.15-1.25的浸膏,备用;
步骤二:将山大颜、柽柳、黄柏、蕨萁、八角莲、白芷、地梭罗分别除杂后,研成粉末,备用;
步骤三:将步骤一得到的浸膏与步骤二得到的粉末混匀,干燥后,粉碎成150-250目的细粉,即得本发明治疗急性泪囊炎的中药散剂。
上述治疗急性泪囊炎的中药散剂的制备方法,步骤一中加原料重量8倍的水浸泡45-55分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮28-32min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮18-22min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.18-1.22的浸膏;优选的,加原料重量8倍的水浸泡50分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮30min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮20min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.20的浸膏。
上述治疗急性泪囊炎的中药散剂的制备方法,步骤三中粉碎成180-220目的细粉;优选的,粉碎成200目的细粉。
上述治疗急性泪囊炎的中药散剂的使用方法,将上述中药散剂用醋调敷患处,每天2次,5天1疗程。
本发明所用主要中药原料的药理如下:
鱼腥草:性微寒,味辛。归肺经。功效与作用:清热解毒、消痈排脓、利尿通淋。用治肺脓疡、痰热咳嗽、肺炎、水肿、脚气、尿路感染、白带过多、痈肿疮毒。鲜汁对金黄色葡萄球菌有抑制作用,水煎剂在体外可明显促进人体周血蛋白细胞吞噬金黄色葡萄球菌的能力。
山大颜 :味苦,性凉。功效与作用:清热解毒、消肿拔毒。用治白喉、扁桃体炎、咽喉炎、痢疾、肠伤寒、胃痛、风湿骨痛。外用治跌打肿痛、外伤出血、毒蛇咬伤、疮疡肿毒、下肢溃疡。
柽柳:性平,味甘,归肺经。功效主治:疏风;解表;透疹;解毒。主风热感冒;麻疹初起;疹出不透;风湿痹痛;皮肤瘙痒。
千里光:性寒,味苦。归肝经、肺经。功效与作用:清热解毒、凉血消肿、清肝明目、杀虫止痛。用治风热感冒、流行性感冒、上呼吸道感染、急性扁桃体炎、咽喉肿痛、肺炎、大叶性肺炎等。
夏枯草:性寒,味辛、苦。归肝经、胆经。功效与作用:清火、明目、散结、消肿。用治目赤肿痛、目珠夜痛、头痛眩晕、瘰疠、瘿瘤、乳痈肿痛、甲状腺肿大、淋巴结结核、乳腺增生、高血压。
黄柏:性寒,味苦。归肾经、膀胱经。功效与作用:清热燥湿、泻火除蒸、解毒疗疮。用治湿热泻痢、黄疸、带下、热淋、骨蒸劳热、盗汗、遗精;疮疡肿毒、湿疹瘙痒。
蕨萁:苦、涩,凉。归脾经。功能主治:清热解毒,消肿散结。用于肺脓疡,眼结膜炎;外用治跌打损伤,蛇咬伤,颈淋巴结结核。
八角莲:功能主治:清热解毒,化痰散结,祛瘀消肿。治痈肿,疔疮,瘰疬,喉蛾,跌打损伤,蛇咬伤。
白茎鸦葱:甘、苦,微凉。功能主治:清热解毒,祛风除湿,平喘。用于感冒发热,哮喘,乳腺炎,疔疮,关节痛,带状疱疹。
白芷:性温,味辛。归胃经、大肠经、肺经。功效与作用:散风除湿、通窍止痛、消肿排脓、解毒、消炎。用治感冒头痛、眉棱骨痛、鼻塞、鼻渊、牙痛、白带、疮疡肿痛。
草藤乌:性凉,味辛。功效主治:疏风清热;解毒消肿。主风热感冒;头痛目赤;痈疮肿毒。
地梭罗:性凉,味淡。功能主治:生肌,拔毒,清热。治烫伤及癣、骨折、烂脚疮。
与现有技术相比,本发明的有益效果为:
本发明治疗急性泪囊炎的中药散剂,采用常见中药材作为原料,制备简单,疗效显著,使用方便,无副作用,具有祛风清热、解毒排脓、祛瘀消肿的功效,可有效治疗急性泪囊炎。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不被此限制。
实施例1一种治疗急性泪囊炎的中药散剂,取下述重量配比的中药原料制备而成(每份取1g):鱼腥草20份、山大颜15份、柽柳15份、千里光10份、夏枯草10份、黄柏10份、蕨萁5份、八角莲5份、白茎鸦葱5份、白芷5份、草藤乌2份、地梭罗2份。
上述治疗急性泪囊炎的中药散剂的制备方法,步骤如下:
步骤一:将鱼腥草、千里光、夏枯草、白茎鸦葱、草藤乌洗净、除杂后,置于砂锅内,加原料重量8倍的水浸泡40分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮25min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮15min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.15的浸膏,备用;
步骤二:将山大颜、柽柳、黄柏、蕨萁、八角莲、白芷、地梭罗分别除杂后,研成粉末,备用;
步骤三:将步骤一得到的浸膏与步骤二得到的粉末混匀,干燥后,粉碎成150目的细粉,即得本发明治疗急性泪囊炎的中药散剂。
典型病例一:孙xx,女,37岁,1年前患者泪囊区出现红肿、坚硬、疼痛、压痛症状,医院检查诊断为急性泪囊炎,采用本发明实施例1中散剂治疗3天,红肿及疼痛减轻,继续治疗5天后,不适症状消失,痊愈,至今无复发。
实施例2一种治疗急性泪囊炎的中药散剂,取下述重量配比的中药原料制备而成(每份取1g):鱼腥草30份、山大颜25份、柽柳25份、千里光20份、夏枯草20份、黄柏20份、蕨萁15份、八角莲15份、白茎鸦葱15份、白芷15份、草藤乌8份、地梭罗8份。
上述治疗急性泪囊炎的中药散剂的制备方法,步骤如下:
步骤一:将鱼腥草、千里光、夏枯草、白茎鸦葱、草藤乌洗净、除杂后,置于砂锅内,加原料重量8倍的水浸泡60分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮35min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮25min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.25的浸膏,备用;
步骤二:将山大颜、柽柳、黄柏、蕨萁、八角莲、白芷、地梭罗分别除杂后,研成粉末,备用;
步骤三:将步骤一得到的浸膏与步骤二得到的粉末混匀,干燥后,粉碎成250目的细粉,即得本发明治疗急性泪囊炎的中药散剂。
实施例3一种治疗急性泪囊炎的中药散剂,取下述重量配比的中药原料制备而成(每份取1g):鱼腥草23份、山大颜18份、柽柳18份、千里光13份、夏枯草13份、黄柏13份、蕨萁8份、八角莲8份、白茎鸦葱8份、白芷8份、草藤乌4份、地梭罗4份。
上述治疗急性泪囊炎的中药散剂的制备方法,步骤如下:
步骤一:将鱼腥草、千里光、夏枯草、白茎鸦葱、草藤乌洗净、除杂后,置于砂锅内,加原料重量8倍的水浸泡46分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮28min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮18min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.18的浸膏,备用;
步骤二:将山大颜、柽柳、黄柏、蕨萁、八角莲、白芷、地梭罗分别除杂后,研成粉末,备用;
步骤三:将步骤一得到的浸膏与步骤二得到的粉末混匀,干燥后,粉碎成180目的细粉,即得本发明治疗急性泪囊炎的中药散剂。
典型病例二:王xx,男,56岁,患者眼眶外上方局部肿胀、疼痛,诊断为急性泪囊炎,滴用抗生素眼液后,无改善,且左眼充血、流泪,有脓性分泌物。后采用本发明实施例3中的中药散剂调敷治疗,治疗1个疗程后,无脓性分泌物,眼部充血、流泪症状减轻,治疗2个疗程后,泪囊区脓液排尽,红肿消退,疮口平复,症状全部消除,痊愈,无复发。
实施例4一种治疗急性泪囊炎的中药散剂,取下述重量配比的中药原料制备而成(每份取1g):鱼腥草27份、山大颜22份、柽柳22份、千里光17份、夏枯草17份、黄柏17份、蕨萁12份、八角莲12份、白茎鸦葱12份、白芷12份、草藤乌6份、地梭罗6份。
上述治疗急性泪囊炎的中药散剂的制备方法,步骤如下:
步骤一:将鱼腥草、千里光、夏枯草、白茎鸦葱、草藤乌洗净、除杂后,置于砂锅内,加原料重量8倍的水浸泡55分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮32min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮22min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.22的浸膏,备用;
步骤二:将山大颜、柽柳、黄柏、蕨萁、八角莲、白芷、地梭罗分别除杂后,研成粉末,备用;
步骤三:将步骤一得到的浸膏与步骤二得到的粉末混匀,干燥后,粉碎成220目的细粉,即得本发明治疗急性泪囊炎的中药散剂。
实施例5一种治疗急性泪囊炎的中药散剂,取下述重量配比的中药原料制备而成(每份取1g):鱼腥草25份、山大颜20份、柽柳20份、千里光15份、夏枯草15份、黄柏15份、蕨萁10份、八角莲10份、白茎鸦葱10份、白芷10份、草藤乌5份、地梭罗5份。
上述治疗急性泪囊炎的中药散剂的制备方法,步骤如下:
步骤一:将鱼腥草、千里光、夏枯草、白茎鸦葱、草藤乌洗净、除杂后,置于砂锅内,加原料重量8倍的水浸泡50分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮30min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮20min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.20的浸膏,备用;
步骤二:将山大颜、柽柳、黄柏、蕨萁、八角莲、白芷、地梭罗分别除杂后,研成粉末,备用;
步骤三:将步骤一得到的浸膏与步骤二得到的粉末混匀,干燥后,粉碎成200目的细粉,即得本发明治疗急性泪囊炎的中药散剂。
实验例:1、临床选择:为了验证本发明治疗急性泪囊炎的中药散剂的效果,我们抽取了200名急性泪囊炎患者进行了药物的实验,平均分为两组,实验组100例,其中男性51例,女性49例,年龄20-70岁,病程1天-1年;对照组100例,其中男性50例,女性50例,年龄18-70岁,病程1天-1年;两组在性别、年龄、临床表现等方面经统计学分析无显著性差异。
2、治疗方法:
实验组:采用本发明实施例5中治疗治疗急性泪囊炎的中药散剂调敷,每天2次,5天1疗程。
对照组:滴抗生素眼液,每天2次,5天1疗程。
3、疗效情况判定标准:治愈:泪囊区脓液排尽,红肿消退,疮口平复,症状全部消除。好转:泪囊区红肿减轻,病灶局限,或有脓液排出,诸症减轻。无效:泪囊区红肿无改善或加重。
4、治疗结果:精确对两组实验的数据进行统计和数理分析,得到具体实验结果如下表:
经临床试验发现,实验组治愈65例中平均治愈时间为(5.32±1.16)天,而对照组治愈46例中平均治愈时间为(8.64±1.58)天,两组比较,P<0.05。
实验证明,本发明中药散剂治疗急性泪囊炎与滴抗生素眼液的功效相比,具有疗效显著,无副作用、安全有效的优点,可有效治疗急性泪囊炎。
Claims (8)
1.一种治疗急性泪囊炎的中药散剂,其特征在于:取下述重量配比的中药原料制备而成:鱼腥草20-30份、山大颜15-25份、柽柳15-25份、千里光10-20份、夏枯草10-20份、黄柏10-20份、蕨萁5-15份、八角莲5-15份、白茎鸦葱5-15份、白芷5-15份、草藤乌2-8份、地梭罗2-8份。
2.根据权利要求1所述的一种治疗急性泪囊炎的中药散剂,其特征在于:取下述重量配比的中药原料制备而成:鱼腥草23-27份、山大颜18-22份、柽柳18-22份、千里光13-17份、夏枯草13-17份、黄柏13-17份、蕨萁8-12份、八角莲8-12份、白茎鸦葱8-12份、白芷8-12份、草藤乌4-6份、地梭罗4-6份。
3.根据权利要求1所述的一种治疗急性泪囊炎的中药散剂,其特征在于:取下述重量配比的中药原料制备而成:鱼腥草25份、山大颜20份、柽柳20份、千里光15份、夏枯草15份、黄柏15份、蕨萁10份、八角莲10份、白茎鸦葱10份、白芷10份、草藤乌5份、地梭罗5份。
4.一种根据权利要求1-3任一项所述的治疗急性泪囊炎的中药散剂的制备方法,其特征在于:步骤如下:
步骤一:将鱼腥草、千里光、夏枯草、白茎鸦葱、草藤乌洗净、除杂后,置于砂锅内,加原料重量8倍的水浸泡40-60分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮25-35min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮15-25min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.15-1.25的浸膏,备用;
步骤二:将山大颜、柽柳、黄柏、蕨萁、八角莲、白芷、地梭罗分别除杂后,研成粉末,备用;
步骤三:将步骤一得到的浸膏与步骤二得到的粉末混匀,干燥后,粉碎成150-250目的细粉,即得本发明治疗急性泪囊炎的中药散剂。
5.根据权利要求4所述的一种治疗急性泪囊炎的中药散剂的制备方法,其特征在于:步骤一中加原料重量8倍的水浸泡45-55分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮28-32min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮18-22min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.18-1.22的浸膏。
6.根据权利要求5所述的一种治疗急性泪囊炎的中药散剂的制备方法,其特征在于:步骤一中加原料重量8倍的水浸泡50分钟,然后用武火煎煮至沸腾后,改用文火继续煎煮30min,过滤,滤出药渣,得到首次煎液,然后向滤渣中加入原料重量5倍的水,武火煎煮至沸腾后,文火继续煎煮20min,过滤,得到二次煎液,合并两次煎液,并浓缩成在60℃时相对密度为1.20的浸膏。
7.根据权利要求4所述的一种治疗急性泪囊炎的中药散剂的制备方法,其特征在于:步骤三中粉碎成180-220目的细粉。
8.根据权利要求7所述的一种治疗急性泪囊炎的中药散剂的制备方法,其特征在于:步骤三中粉碎成200目的细粉。
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