CN105920036B - A kind of concocting method of Tibetan medicine ingredient biotite calx - Google Patents
A kind of concocting method of Tibetan medicine ingredient biotite calx Download PDFInfo
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- CN105920036B CN105920036B CN201610483232.6A CN201610483232A CN105920036B CN 105920036 B CN105920036 B CN 105920036B CN 201610483232 A CN201610483232 A CN 201610483232A CN 105920036 B CN105920036 B CN 105920036B
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- biotite
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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Abstract
The invention discloses a kind of concocting method of the biotite ash in eight mineral grey of Tibetan medicine active constituent, this method includes that will urinate biotite with billy, up to drawing processing fermentation detoxification, the right amount of auxiliary materials such as Fructus Hippophae extractum, borax, nitre, sulphur, calcination, cleaning is added and dry is made.The method of the present invention can obviously reduce the toxicity of biotite mineral grey, and keep activity.
Description
Technical field
The invention belongs to Tibetan medicine's pharmaceutical field, it is related to a kind of preparation method of eight calxs during Tibetan medicine is helped very much, and in particular to eight
The concocting method of one of calx biotite calx.
Background technology
Tibetan medicine's pharmacy is one of five big subject of Tibetan, is the summary of experience that Tibetan combats the disease for thousands of years.
Tibetan medicine is whole, is a theoretical system, and Tibetan medicine development must comply with the principle of Tibetan medicine's theory, if Tibetan medicine development is detached from
Five source of Tibetanmedicine, Six-element, eight property, 17 effect scheduling theories and special Preparation process technique, cannot be referred to as Tibetan medicine.
Tibetan medicine's Literary masterpiece《Four doctor's allusion quotations》In point out：" world empty is not medicine, as long as processing procedure is in place ".So far it looks into
Bright plant, animal, mineral substance Tibetan medicine material have more than 3000 to plant, and have its specific Preparation process technique, a kind of drug per taste medicinal material
The method of the difference for the treatment of and prescription, processing is also just very much.Such as：The most common myrobalan of Tibetan medicine, seen literature record and
Usually with there is 4 kinds of concocted methods, also there are many methods in legend；Also there are many concocting methods of detoxifying for vomiting nut；Mercury (mercury)
Processing procedure has as many as 15 kinds.In traditional Tibetan medicine's pharmacy, assistant, which is developed very much, to be had to after thousands of times calcining is processed into ash
It uses, to retain drug effect, removes toxic side effect.This peculiar technique and made of this technique, drug claims " assistant is too " Tibetan medicine
Or " benevolence blueness helps pearl wood by the emperor himself ".
" assistant is too " is the abbreviation of Tibetan language " benevolence blueness Europe Qu Zuozhu admires wooden "." assistant " is refining, and " too " refers to ash, powder, " assistant is too "
Mean be sintered into ash (also have title assistant platform, assistant tower), be the successive dynasties name Tibetan medicine by being processed into hypertoxic mercury special processing
Drug nontoxic, with peculiar curative effect, the most valuable treasure being referred to as by the snowy region people in Tibetan medicine.Modern medicine and pharmacology basic theory is known as
" mercury baptize method ".It is removed in Tibetan medicine " assistant is too " and also contains 8 kinds of metals, 8 kinds of mineral and hundreds of supplementary materials outside mercury, it is a kind of
Special processing technology with Tibetan medicine conventional representative is World Immaterial Heritages by China's application, can slap now
It holds the people that " assistant is too " tradition processes skill and only has tens in 5, China Tibetan area.
Point out that " assistant is too " has effects that adjust blood, clearing heat and detoxicating, nourishing and fit keeping function in Tibetan medicine cures allusion quotation books, in valuable classics
Compatibility is used as mineral drug important simply in tibetan traditional medicine prescription, be usually used in apoplexy, hypertension, heart disease, arthragra and
The treatment of the diseases such as inflammation, such as Tibetan medicine Renqingmangjue, Renqing Changjue, seat pearl darcy, Wei Zhen Zhu Wan, Qishiwei Turguoise pills are valuable
All contain in Tibetan medicine kind " assistant is too ".Animal experiment shows that " assistant is too " there is good anticonvulsion, antipyretic, anti-inflammatory and enhancing to be immunized
Effect.Point out that " assistant is too " has effects that adjust blood, clearing heat and detoxicating, nourishing and fit keeping function in Tibetan medicine cures allusion quotation books, in valuable classics
Compatibility is used as mineral drug important simply in tibetan traditional medicine prescription, be usually used in apoplexy, hypertension, heart disease, arthragra and
The treatment of the diseases such as inflammation
The processing of " assistant is too " mainly has 8 gold medal ashes and 8 mine systems grey, and 8 gold medal ash main materials include；8 kinds of metals both gold,
Silver, red metal, bronze, brass, iron, lead, tin are referred to as " can hold eight iron ", and it is nature that the main material of 8 mine systems ash, which includes 8 kinds of mineral,
Copper, gold ore, silver ore, magnetite, aluminite, orpiment, realgar, red mica are referred to as " can hold eight yuan ".These raw materials are after refining
The ingredient of obtained product with it is complicated, and this also be exactly its special efficacy basis.Previous studies show these metals
With in mine contain more mercury.Mercury simple substance is that a kind of toxicity is big and the very big liquid of proportion, is a kind of toxicity mineral.Therefore,
These metals and mine need to pass through Detoxification processing and process, and become the compound or steady of the smaller mercury of toxicity after processing
Fixed structure.
When doing ' assistant is too ', raw material selection is specific.So-called eight gold medal refers to just eight kinds of metals, and yellow gold is smelt
Bronze, ore make mineral powder, and whole powder is all added in ' assistant is too ' mercury washing lotion and goes to refine, and this link need to continue for
Three or four months, it is technologic require it is particularly severe, if system does not achieve and has very major injury to human body.
Tibetan medicine processing is sufficiently complex, and the period is long.By taking " benevolence blueness helps pearl and admires wooden (assistant is too) " as an example, Wei Zhen Zhu Wan, benevolence
Contain in the precious Tibetan medicine such as green often feel, 70 taste coral balls, Tibetan medicine Renqingmangjue, seat pearl darcy, "Zuotadezima", Qishiwei Turguoise pills
There is benevolence blueness assistant pearl to admire wooden, which has a variety of diseases such as various acute and chronic digestive systems and cardiovascular and cerebrovascular internal organs good
Curative effect.The effect of cooperation other medicines can increase it, but its entire processing process is most complicated in Tibetan medicine." benevolence blueness assistant pearl is admired
The development process of wood " takes around 42 days or so, mainly point 4 processes：
1) it processes sulphur, vehement eight yuan (natures of eight iron (ash is respectively made in gold, silver, red metal, brass, iron, lead, tin) and energy can be held
Ash made of the calcining such as copper, gold ore, silver ore, magnetite, aluminite, orpiment, realgar, red mica).
2) it dispels dirty process：The cleaning of three pungent powder and mercury then successively plus alkali flower, green salt powder, three sour waters, all kinds of salts,
Saltcake, borax, garlic water, butter etc., are sufficiently stirred about 21d, and gaza's spine water is stayed overnight after being cleaned with clear water.
3) cooking method detoxification process：It boils greatly, in mercury obtained by upper step plus after 3 kinds of gypsum rubrums and three sour waters etc., is used in stone pot
Warm water boils, and about takes 4 days or so；In boil：Water and three sour waters of eight iron ashes etc. can be held after mercury obtained as above is eluted with water altogether
It boils, takes around 2 days or so；It is short to boil：After mercury obtained as above is eluted with water, adds rhizome of Chinese monkshood powder and eight iron ashes can be held and equally boil,
Mercury is taken out after about l days to be cleaned with clear water.
4) " enemy is met to deform " method：Mercury obtained as above is placed in stone cistern after adding the sulphur processed got ready, eight iron ashes can be held etc.,
It is degree to be stirred well to water breakthrough Argent grain.It is final to be processed into black powder finished product " benevolence blueness helps pearl wood by the emperor himself ".
Invention content
The purpose of the present invention is to provide a kind of concocting methods of biotite calx.This method is to help very much big gun in preparation method
The processing procedure of biotite in the vehement eight yuan of processes of system energy.
A kind of concocting method of biotite of the present invention, includes the following steps：
1) detoxification：Biotite is placed in container, billy urine is added and reconciles into paste up to drawing, is sent out at capping, heat
Ferment dries up to detoxification biotite；
2) it is assigned in auxiliary material：Detoxification biotite made from upper step is placed in container, adds Fructus Hippophae extractum, borax, nitre, sulphur suitable
Amount, reconciles into paste with water, makes granule, dry；
3) it is calcined：Granule is put into terrine and is calcined, it is cooling up to biotite ash；
4) it cleans：The biotite ash that upper step obtains is cleaned up with hot water, is dried, is ground up, sieved up to biotite ash.
The method of aforementioned present invention, in step 1), biotite is 10 with billy urine w/v：130kg/ml, it is male
It is 1 that goat, which urinates and reaches drawing volume ratio,：1.
The method of aforementioned present invention, in step 2), biotite：Fructus Hippophae extractum：Borax：Sulphur：The weight ratio of nitre is 10：
1.25：0.35：2.6：0.53, the granule is the triangular pyramid granule of egg size.
The method of aforementioned present invention, the step 3) calcination refers to that small fire is forged 1.5 hours in, then is forged 5 hours with big fire.
Term：" Da La " refers to remaining Yoghourt after extraction butter.
In one embodiment, the concocting method of a kind of biotite of the invention, includes the following steps：
1) detoxification：
Biotite 10kg is placed in container, adds billy urine 130ml, up to 130ml is drawn, reconciles into paste, capping, heat
Place's fermentation, drying can detoxification；
2) it is assigned in auxiliary material:
Biotite made from upper step is placed in container, Fructus Hippophae extractum 1.25kg, borax 0.53kg, sulphur 2.6kg, nitre are added
0.53kg reconciles into paste with water, makes the triangular pyramid shape granule of egg size, dries；
6) it is calcined：Granule is put into terrine and is calcined, it is cooling up to biotite ash；The calcination refers to that small fire is forged in
1.5 hours, then forged 5 hours with big fire；
4) it cleans：The biotite ash that upper step obtains is cleaned up with hot water, is dried, is ground up, sieved up to biotite ash.
Seven mineral greys after biotite ash and detoxification calcination made from the method for the present invention are mixed uniform, obtained in helping too
Eight mineral greys.Assistant is configured to be used to very much prepare Wei Zhen Zhu Wan, Renqing Changjue, Tibetan medicine Renqingmangjue, sit the Tibetan such as pearl darcy
Medicine can reduce toxicity, improve curative effect.Pearl darcy is such as sat with soothing the liver, stomach invigorating, heat-clearing, more ulcer and detumescence and other effects.
Eight mineral greys that biotite ash made from the method for the present invention is mixed to get with seven mineral greys after detoxification calcination
With " assistant is too " and its compound preparation of the compositions such as 8 calxes (or 8 iron ash), mercury, animal safety evaluation study has been carried out,
The result shows that：Under clinical equivalent dosage and in clinical medicining cycle, to tested experimental animal without apparent harmful effect, demonstrate
Tibetan medicine the assistant too reasonability of compound tradition medication, safety and science, can substantially reduce or eliminate its toxicity or side effect.
The method advantageous effect of the present invention shows following two aspects：
(1) method of the invention, can obviously reduce the toxicity of eight calxs, it is a big feature of Tibetan medicine and pharmacology that mineral, which are used as medicine, is faced
Bed applicating history is long, and processing procedure is unique.The concocting method of the present invention can substantially reduce or eliminate toxicity or side effect, be made
Biotite ash assistant empress dowager is made can also eliminate the toxicity of mercury.
(2) effect to promoting Tibet's drug industry to develop." assistant is too " is rigorous multiple as the essence and fabrication processing of Tibetan medicine
Miscellaneous, unique curative effect is obvious to all, the synergistic effect that " assistant is too " plays in Tibetan medicine.Although the method for the present invention only prepares assistant
A part too in technique, the i.e. concocting method of biotite calx, can make the Tibetan medicine for having national characters, curative effect original can be gradually
It is recognized, to preferably benefit the whole mankind.
Specific implementation mode
Following embodiment is used to be explained further the essence of the present invention, the range of but do not limit the invention in any way.
The processing of 1 biotite calx of embodiment
1) detoxification：
Biotite 10kg is placed in container, adds billy urine 130ml, up to 130ml is drawn, reconciles into paste, capping, heat
Processing fermentation, drying can detoxification；
2) it is assigned in auxiliary material:
Biotite made from upper step is placed in container, Fructus Hippophae extractum 1.25kg, borax 0.53kg, sulphur 2.6kg, nitre are added
0.53kg reconciles into paste with water, makes the triangular pyramid shape granule of egg size, dries；
3) it is calcined：Granule is put into terrine and is calcined, it is cooling up to biotite ash；The calcination refers to that small fire is forged in
1.5 hours, then forged 5 hours with big fire；
4) it cleans：The biotite ash that upper step obtains is cleaned up with hot water, is dried, is ground up, sieved up to biotite ash,
It saves backup.
The processing of 2 biotite calx of embodiment
1) detoxification：
Biotite 100kg is placed in container, adds billy urine 1300ml, up to 1300ml is drawn, reconciles into paste, add
Lid, heat treatment fermentation, drying can detoxification；
2) it is assigned in auxiliary material:
Biotite made from upper step is placed in container, Fructus Hippophae extractum 12.5kg, borax 5.3kg, sulphur 26kg, nitre are added
5.3kg reconciles into paste with water, makes the triangular pyramid shape granule of egg size, dries；
3) it is calcined：Granule is put into terrine and is calcined, it is cooling up to biotite ash；The calcination refers to that small fire is forged in
1.5 hours, then forged 5 hours with big fire；
4) it cleans：The biotite ash that upper step obtains is cleaned up with hot water, is dried, is ground up, sieved up to biotite ash,
It saves backup.
Seven mineral greys after biotite ash and detoxification calcination made from the method for the present invention are mixed uniform, obtained " help too "
One of active constituent " eight mineral greys ".
Toxotest：
The ingredients such as the mercury after seven mineral greys, 8 gold medal systems ash and processing after the biotite ash of the present invention is calcined with detoxification
Composition " assistant is too " passes through acute toxicity test, subacute toxicity test, the distribution examination of single-dose mercury of animal experiment test assistant too
It tests, long-term mercury accumulation toxicity test.Acute toxicity test is found：The each group KM mouse of median lethal dose experiment do not occur dead in
Malicious phenomenon does not make assistant too LD50；The maximal tolerance dose of assistant too is 120gkg-1.Subacute toxicity test is found：Assistant exists very much
Low dosage (10.5mgkg-1d-1) and when middle dosage (2.0mgkg-1d-1), can reduce Wistar rat blood serum ALT,
AST, Crea are horizontal, and have significant difference in low dosage；High dose (2000mgkg-1d-1) Zuo Tai can significantly increase
Increase serum ALT, AST, Crea, MDA are horizontal；Serum BUN and GSH level are reduced as dosage increases, and are closed in conspicuousness dose-effect
System.Single-dose distribution experiment is found：Assistant too single-dose for 24 hours after, mercury content goes out in the kidneys of Wistar rats, liver and lung
Trend is now increased, and is in dose dependent in kidney.Long-term cumulative toxicity test is found：KM mouse are in clinical equivalent dosage
(8.0mgkg-1day-1) administration helps too 4.5 months, is discontinued 1.5 months, occurs mercury storage kidney when 2.5 months
Product gradually reduces again after drug withdrawal, and mercury content and Serum ALT in liver, spleen and brain, and AST, TBIL, there are no significant by BUN, Crea
Variation.
The above result shows that the toxicity of biotite ash made from method of the invention reduces, safely and effectively.
Claims (2)
1. a kind of concocting method of biotite, includes the following steps：
1) detoxification：Biotite is placed in container, billy is added to urinate 130ml, up to 130ml is drawn, reconciles into paste, capping, heat
Processing fermentation, drying can detoxification；
2) it is assigned in auxiliary material:Biotite made from upper step is placed in container, adds Fructus Hippophae extractum, borax, nitre, appropriate sulphur, uses water
Paste is reconciled into, granule is averagely done, is dried；
3) it is calcined：Granule is put into terrine and is calcined, it is cooling up to biotite ash；
4) it cleans：The biotite ash that upper step obtains is cleaned up with hot water, is dried, is ground up, sieved up to biotite ash；Its
In, in step 1), biotite is 10 with billy urine w/v：130kg/ml；In step 2), biotite：Fructus Hippophae extractum：Boron
Sand：Sulphur：The weight ratio of nitre is 10：1.25：0.35：2.6：0.53.
2. the method as described in claim 1, in step 3), the calcination refers to that small fire forges 1.5 hours and forges 5 with big fire again in
Hour.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1038406A (en) * | 1988-10-15 | 1990-01-03 | 西藏自治区藏医院 | The processing method of medicinal MERCURY POWDER (seat platform) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1038406A (en) * | 1988-10-15 | 1990-01-03 | 西藏自治区藏医院 | The processing method of medicinal MERCURY POWDER (seat platform) |
Non-Patent Citations (1)
| Title |
|---|
| 传统矿物藏药及其炮制工艺研究;杨玉等;《中央民族大学学报(自然科学版)》;20080815;第17卷(第03期);第83-88页 * |
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