CN105918559A - Ginkgo tea capable of reducing blood sugar - Google Patents
Ginkgo tea capable of reducing blood sugar Download PDFInfo
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- CN105918559A CN105918559A CN201610317413.1A CN201610317413A CN105918559A CN 105918559 A CN105918559 A CN 105918559A CN 201610317413 A CN201610317413 A CN 201610317413A CN 105918559 A CN105918559 A CN 105918559A
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Abstract
The invention discloses a ginkgo tea capable of reducing blood sugar. The ginkgo tea capable of reducing blood sugar is prepared from bitter gourd, fructus lycii, rhizoma atractylodis macrocephalae, radix polygonati officinalis, radix paeoniae rubra, radix puerariae, radix angelica sinensis, maltodextrin, ginkgetin, tea polyphenol, rebaudioside, vitamin, a thickener, a cosolvent, a dispersant, an antioxidant, a flavor enhancer and a scenting agent. The ginkgo tea capable of reducing blood sugar is prepared through the steps of liquor extraction, clear paste preparation, granulation, sterilization and the like. The ginkgo tea has the effects of reducing blood sugar and the like, and a prepared drink is good in taste and mellow in flavor; no preservative or pigment is added in the ginkgo tea capable of reducing blood sugar, essence is extracted from pure natural plants, the cold water tea brewing technology is broken through, the low temperature extraction technology is adopted, it is guaranteed that active ingredients in the plants are not damaged, the ginkgo tea can be easily absorbed by the human body after being drunk, and the shortcomings of a traditional product are overcome as the ginkgo tea is easy to dissolve and absorb.
Description
[technical field]
The invention belongs to tea processing technique field, be specifically related to a kind of blood sugar lowering Folium Ginkgo tea and preparation method thereof.
[background technology]
Ginkgoaceae plant Ginkgo biloba is the endemic tree of China, has another name called maidenhair tree, and the age of tree, up to more than thousand, is ancient
For Permian Period Relict Plant, there is the title of " living fossil " in plant kingdom, be the most ancient in existing seed plant
Relict Plant.Modern science shows, the chemical composition of Folium Ginkgo is sufficiently complex, wherein containing flavone in Folium Ginkgo
The effective ingredient such as class, terpenoid, phenols, healthy trace elements with household and several amino acids.Folium Ginkgo extract contains greatly
The ginkgetin of amount, ginkgetin is highly resistant to and prevents the electromagnetic radiation such as computer, mobile phone to make human body
The infringement become, particularly obvious to the protective effect of brain cell, also have vessel softening, remove rubbish in blood,
Drop three fat, remove the effects such as free radical.In active substance, the content of flavone decides the medical value of Folium Ginkgo,
Go for more flavone, it is critical only that the extracting method of Folium Ginkgo；During traditional extraction, solvent exists
It is easily accessible cell under conditions of heating, but solable matter is higher at the condition dissolubility of heat, is successively dissolved
And the highest permeability occurs, and to cause that extraction ratio is low, active component is low, and technique is loaded down with trivial details, the production cycle is long.
Tea polyphenols is the general name of Polyphenols of Tea, is a kind of pure natural complex, and its content accounts for Folium Camelliae sinensis and does
The 10%-25% (Forint phenol method) of material total amount.Tea polyphenols is by catechin (flavanol compound), anthocyan
(leucoanthocyanidin and anthocyanidin), anthoxanthins (flavone and flavonols), phenolic acid and the big material group of depside four
Becoming, wherein catechin is mostly important, and activity is the highest, accounts for the 70%-80% of tea polyphenols total amount.Tea polyphenols
It is a kind of high-efficient pure natural antioxidant, it is possible to remove human free radical, enhancing human body immunity power, has anti-swollen
The multiple medical health care functions such as tumor, radioprotective, antiviral, defying age, lowering blood-fat and reducing weight, also have suppression tremulous pulse
The effects such as atherosis, removing halitosis, enhancing vascular resistance ability.The oxidation resistance ratio of tea polyphenols
Strong 3-9 times of VE, Butylated hydroxyanisole (BHA) and dibenzylatiooluene (BHT), the most extensively should
The every field such as oxidation resistanct fresh-keeping, medicine, health product, cosmetics and the article of everyday use for varieties of food items.Carry
Taking is that tea polyphenols produces and the first step of preparation, improves the extraction ratio of tea polyphenols the most at low cost, and protects
Hold the biological activity of tea polyphenols, be the bottleneck problem in producing.It is usually in commercial production after first Folium Camelliae sinensis being pulverized
Sieve, then extract with water or high concentration ethanol aqueous solution under the high temperature conditions.Used high-temp extracting method is deposited
Problem have: (1) energy consumption is high；(2) Product Activity low (tea polyphenols is oxidizable)；(3) extract is miscellaneous
Matter content is high (high temperature easily leaches impurity)；(4) subsequent purification is often, and tea polyphenols loss amount is big；(5)
Easy gelatinizing during tea-leaf power high-temp extracting, is difficult to filter；(6) high to equipment requirements.Therefore tea polyphenols is carried
The improvement of access method is significant with innovation.
Stevioside has excellent physiological property and stability, is widely used in as a kind of new food additive
The industries such as food, beverage, wine brewing, medicine, daily-use chemical industry, not only extraction process reaches its maturity, and extraction ratio is also
Day by day improve.The method extracting stevioside at present from Stevia leaves mainly has organic solvent extraction and water
Extraction method, wherein organic solvent extraction solvent consumption is big, cost is high, practicality is not good enough.Hot water extraction is
Application comparison extracting method widely at present, in industry, the general technology flow process of stevioside's water extraction is as follows: sweet
Ye Juye → water logging (8-10h) → coarse filtration → removing impurity by means of precipitation → fine straining → purification → decolouring → desalination → concentrate drying,
Wherein water logging extraction and purification are the committed step of this technique, and it is 80 DEG C that extracting process widely is compared in use
Hot water extracted many times, the method for purification now more uses resin absorption to separate, and the main active charcoal of method of decolouring takes off
Normal complexion resin decolorization two kinds.The shortcoming of this technique is that extraction time is long, and thermal energy consumption is high, and High Temperature High Pressure is to equipment
Processing safety requires height, and in purification and decolorization, seriality is poor, and resin and reagent dosage are big simultaneously, tree
Fat utilization rate is low, and operation is time-consuming long.
When blood glucose value is higher than being hyperglycemia normal range.Hyperglycemia is also generally in " three high " described in everybody
One is high.Additionally " two is high " is hypertension and hyperlipemia respectively.Fasting glucose normal value 6.1mmol/L with
Under, the normal value of two hours blood glucoses is at below 7.8mmol/L after the meal, if above this scope, is referred to as height
Blood glucose.Under normal circumstances, human body can guarantee blood glucose by hormonal regulation and this two big regulation system of neuroregulation
Source and outlet keep balance, make blood glucose maintain certain level.But at inherited genetic factors (such as glycosuria patient and his family
Race's history) with under the common effect of environmental factors (such as irrational meals, obesity etc.), two big regulatory functions are sent out
Raw disorder, arises that the rising of blood sugar level.Human body is damaged by short time, disposable hyperglycemia without serious.
Such as under stress state or during excited, high-pressure, may occur in which of short duration hyperglycemia；Once feed is big
The saccharide of amount, it is possible to of short duration hyperglycemia occurs；Subsequently, blood sugar level gradually recovers normal.But long-term height
Blood glucose can make each histoorgan generation pathological changes of whole body, causes the generation of acute and chronic complication.Such as dehydration, electrolysis
Matter disorder, malnutrition, resistance decline, impaired renal function, neuropathy, retinopathy, cardiovascular and cerebrovascular vessel
Disease, diabetic foot etc..Control hyperglycemia imperative.First have to remove the inducement that blood glucose raises, as infected
The reason raised in induction blood glucose.It is comprehensive that the treatment of prediabetes and diabetes should follow " five drive carriage "
Treatment principle, including rational diet, suitable motion, the study of Diabetes Mellitus Knowledge, to blood glucose and the state of an illness
Monitoring and the treatment of medicine.Therefore, research and development take that compatibility is simple, drink conveniently, evident in efficacy
Chinese medicine preparation is significant to controlling hyperglycemia.
[summary of the invention]
The technical problem to be solved in the present invention is to provide a kind of blood sugar lowering Folium Ginkgo tea, to solve to prepare in prior art
Ginkgetin extraction ratio and active component are low, and technique is loaded down with trivial details, and the production cycle is long；Low (the tea of tea polyphenols activity of preparation
Polyphenol is oxidizable) and extract impurity content height (high temperature easily leaches impurity)；Stevioside's purification and decolorization
Middle seriality is poor, and resin and reagent dosage are big, and resin utilization rate is low, and operation is time-consuming long；Tea product blood sugar lowering
The problems such as weak effect.The Folium Ginkgo tea of the present invention have the effects such as blood sugar lowering, make that beverage mouthfeel is good, taste is aromatic；
The blood sugar lowering Folium Ginkgo tea of the present invention refine elite without any preservative and pigment, pure natural plant, breach
Cold water is made tea technology, utilizes low-temperature extraction technology, it is ensured that the active component in plant is not destroyed, after drinking
Easily being absorbed by the body, it is readily soluble and is easily solved the short slab of traditional product by absorption；The blood sugar lowering Semen Ginkgo of the present invention
Tea frozen water, cold water, brewed in hot water even can, unique flavor, facilitate all ages drunk by people.
In order to solve above technical problem, the present invention by the following technical solutions:
A kind of blood sugar lowering Folium Ginkgo tea, in units of weight portion, including following raw material: Fructus Momordicae charantiae 150-350 part, Chinese holly
Fructus Lycii 150-350 part, Rhizoma Atractylodis Macrocephalae 150-350 part, Rhizoma Polygonati Odorati 80-160 part, Radix Paeoniae Rubra 80-160 part, Radix Puerariae 60-80
Part, Radix Angelicae Sinensis 60-80 part, malt extract stick with paste 30-60 part, ginkgetin 1-3 part, tea polyphenols 1-3 part, sweetleaf
Chrysanthemum glycoside 1-3 part, vitamin 1-3 part, thickening agent 0.8-2 part, cosolvent 0.8-2 part, dispersant 0.8-2 part,
Antioxidant 0.8-2 part, tasty agents 0.5-1.5 part, flavouring agent 0.5-1.5 part；
The preparation method of described blood sugar lowering Folium Ginkgo tea, comprises the following steps:
S1: pulverize after Fructus Momordicae charantiae, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Odorati, Radix Paeoniae Rubra, Radix Puerariae, Radix Angelicae Sinensis are respectively dried, mistake
40-60 mesh sieve, puts in ultrasonic extraction equipment, extracts after adding the 2000-7000 abundant moistening of part water,
The condition extracted is: ultrasonic power is 120-180W, and Extracting temperature is 40-70 DEG C, and extraction time is
30-60min；
S2: step S1 is extracted medical filtration, is sequentially added into ginkgetin, tea polyphenols, Folium Stevlae Rebaudianae after puckery
Glycoside, vitamin, thickening agent, cosolvent, dispersant, antioxidant, tasty agents, flavouring agent, at rotating speed be
Stirring 1-3min under 200-500r/min, be uniformly mixed liquid, concentrates the filtrate to temperature when being 64-66 DEG C
Relative density is the clear paste of 1.32-1.38；
S3: the clear paste of step S2 is spray-dried to water content≤6% at temperature 200-220 DEG C, after pulverizing
Cross the sieve of 200-400 mesh, prepare powder；
S4: the powder of step S3 and malt extract are stuck with paste, 50-100 part water uses pelletize mechanism after being sufficiently mixed
Becoming granule, finally prepared described granule is 134-136 DEG C in temperature, pressure is 210-230KPa,
Time is sterilizing under 20-40s, obtains blood sugar lowering Folium Ginkgo tea；
The preparation method of ginkgetin described in step S2 comprises the following steps:
(1) carry out pulverizing and cross 40-80 mesh sieve by dry Folium Ginkgo, prepare Ginkgo Leaf；
(2) water of 38-62 DEG C is used to extract the Ginkgo Leaf that step 1 prepares, solid-to-liquid ratio in extraction
For 1:12-14 (W/V), extraction time is 2.5-3.5h, extracts 2-3 time, filtration, merging filtrate after extraction,
Prepare mixing lixiviating solution；
(3) mixing lixiviating solution concentrate drying step 2 prepared, prepares extraction cream, is used in extraction cream 5.5-6
The water of 45-55 DEG C of times volume dissolves, and uses anhydrous ethyl acetate solvent to carry out extraction 2-3 time, continuation
Carrying out repeatedly crystallization treatment with anhydrous ethyl acetate, in crystallization process, solid-to-liquid ratio is 1:5.2-5.4 (W/V), system
Obtain crystal crude product；
(4) crystal crude product step 3 prepared is through supercritical CO2Extraction, the condition of extraction: extraction kettle
Pressure is 12-18MPa, and extraction temperature is 42-45 DEG C, and extraction time is 32-40min, prepares ginkgetin；
The preparation method of tea polyphenols described in step S2 comprises the following steps:
A () will cross 40-80 mesh sieve after group's sieve tea pulverizing, be the ethanol water of 40%-60% with mass fraction
Mix for 1:16-20 in mass ratio, extract 2-3 time at temperature is 36-40 DEG C, each 20-30min, mistake
Filter, merging filtrate, concentrate, prepare tea polyphenols crude extract；
(b) by step a prepare tea polyphenols crude extract join in KCl solution, pH regulator to 6.8-7.2,
Under centrifugal rotational speed is 4000-4500r/min, removes impurity, uses 0.45 μm filter membrane to be 34-36 DEG C in temperature
Under the solution after centrifugal is filtered, prepare filtrate；
C filtrate ether extraction that step b is prepared by (), freezing, prepare tea polyphenols after drying；
The preparation method of stevioside described in step S2 comprises the following steps:
(A) crossing 40-80 mesh sieve after being pulverized by Stevia leaves, be dipped in water immersion 1-1.2.h, solid-to-liquid ratio is
1:20-25 (W/V), is 100-120W at ultrasonic power, and Extracting temperature is 40-60 DEG C, extraction time
For extracting under 20-30min, prepare Folium Stevlae Rebaudianae medicinal liquid；
(B) the Folium Stevlae Rebaudianae medicinal liquid that step A prepares is crossed the filter cloth of 120-180 mesh, prepares Folium Stevlae Rebaudianae filtrate；
(C) the Folium Stevlae Rebaudianae filtrate prepared to step B adds the NaAl of filtrate percentage by weight 0.8%-1%
(SO4)2Ca (OH) with filtrate percentage by weight 1%-1.4%2, tune pH value is 6.8-7.2,
At temperature 44-48 DEG C, stand 3.2-3.5h, prepare the solution after the removal of impurity；
(D) containing sweetleaf during the solution filter after removal of impurity step C prepared is filtered and concentrated to every milliliter
Chrysanthemum glycoside 10%-25%, uses macroporous adsorbent resin ADS-8 separating-purifying to prepare the liquid of stevioside, condition
For: resolving agent is the ethanol solution of 55%-65%, and its consumption is 1-3 times of macroporous adsorbent resin volume, water
Washing district is deionized water, and absorption with macroporous adsorbent resin regenerated solvent is the KOH solution of 2%-4%, and adsorption zone is flowed
Speed 6-10BV/h, desorption zone flow velocity 15-20BV/h, water wash zone flow velocity 20-25BV/h, renewing zone flow velocity
6-8BV/h, switching time is 700-750s, and temperature is 40-50 DEG C, and pressure is 0.4-0.9MPa；
(E) stevioside's liquid that step D prepares is concentrated, carry out at temperature is 200-220 DEG C
It is spray-dried, prepares stevioside.
Further, during described vitamin includes vitamin A, vitamin C, vitamin D and vitamin E
One or more.
Further, one during described thickening agent includes xanthan gum, guar gum, locust bean gum and locust bean gum or
Multiple.
Further, described cosolvent is polyvinylpyrrolidone.
Further, described dispersant includes following component: potassium carboxymethylcellulose, agar, modified starch,
One or more in polyacrylic acid potassium and potassium alginate.
Further, described antioxidant includes food grade antioxidant 9701, food grade antioxidant BHT, food
One in level antioxidant different VC potassium, food grade antioxidant BHA and food grade antioxidant MSK-NE150
Or it is multiple.
Further, one or more during described tasty agents includes inosinic acid potassium and guanyl potassium.
Further, described flavouring agent is methyl cyclopentenyl ketone.
Pharmacological action of the present invention is as follows:
Fructus Momordicae charantiae have blood sugar lowering, blood fat reducing, antitumor, pre-preventing bone rarefaction, endocrine regulation, antioxidation,
Antibacterial and improve the medicinal and health care such as body immunity.Pharmacological research shows: Fructus Momordicae charantiae crude extract has aobvious
The reduction blood glucose effect write, measured by radioimmunoassay Fructus Momordicae charantiae extract all has with Insulin receptor INSR, insulin antibody
Significantly association reaction, shows that it and islets of langerhans have common antigenicity and biological activity.Fructus Momordicae charantiae crude extract has class
Effect like insulin.
Fructus Lycii contains abundant carotene, vitamin A, B1, B2, C and the eye health such as calcium, ferrum
Required nutrition.It is improved the effect of immunity of organisms, can be with QI invigorating essence by force, nourishing the liver and kidney, defying age, only
Quench one's thirst, warming up body, antineoplastic effect.Regulating blood sugar, reduces blood pressure, prevent and treat hypertension, heart disease,
The diseases such as arteriosclerosis.
The effect of the Rhizoma Atractylodis Macrocephalae mainly has invigorating the spleen and regulating the stomach, calmness, vasodilation, anticoagulant, anti-gastric-ulcer, protects the liver profit
Gallbladder, diuresis, strong, improve immunity, reduce blood glucose, antioxidation, antibacterial etc..
Rhizoma Polygonati Odorati another name even bamboo, western bamboo, mountain maize, have nourishing YIN and moistening the lung；Nourishing the stomach to promote the production of body fluid.Cough caused by dryness；Chronic cough；Heat
The dry throat and mouth of sick cloudy liquid consumption wound；Interior-heat is quenched one's thirst；Deficiency of YIN diseases caused by exogenous pathogenic factor；Dizzy dizziness；Muscle arteries and veins spasm and pain.
On the impact of blood glucose with 0.5g/kg Rhizoma Polygonati Odorati preserved material to rabbit intramuscular injection, blood glucose can be made to raise. oral
Rhizoma Polygonati Odorati extractum, then blood glucose is fallen after rising, and the hyperglycemia causing epinephrine has significant inhibitory action, right
The Hyperglycemia In Stz-induced Diabetic Rats that glucose, alloxan cause also has inhibitory action.
The main component of Radix Paeoniae Rubra includes paeoniflorin, Albiflorin, oxypaeoniflorin, benzoylpaeoniflorin, Chinese herbaceous peony
Medicine Ji ketone, Lactiflorin., daucosterol, additionally, possibly together with d-catechin i.e. d-cachou extract and gallotannin,
Benzoic acid etc..Research also finds, Radix Paeoniae Rubra is possibly together with fatty oil, resin, sugar, starch, phlegmatic temperament and protein
Deng.Research shows, high viscid blood patients with coronary heart disease is changed the effect of hemorheological property by d-catechin, can make complete
Blood viscosity when erythrocyte electrophoretic time reduces.Additionally, Radix Paeoniae Rubra can regulate TXA2/PGI2 by affecting calcium metabolism
Balance atherosclerosis, its effect is better than calcium channel blocker.And, the water-alcohol becoming leaf Peony Root carries
Take thing, have significant sedation and some analgesic effect, moreover it is possible to the slight acidity improving gastric juice；Can be used for changing
Feed desire, digestive function and some neuropathy.
Radix Paeoniae Rubra has effect to blood glucose, liver, it is possible to reduce blood glucose, the liver protecting.
Radix Puerariae has the effects such as heat clearing away, decomposing alcohol, invigorating the spleen and regulating the stomach, relieving alcoholism and protecting the liver, to reduce blood fat, blood pressure,
Blood glucose, auxiliary treatment coronary heart diseases and angina pectoris, nervous headache etc. have positive effect.
Radix Angelicae Sinensis mainly containing sucrose, several amino acids, volatile oil and n-butene, lactone, nicotinic acid, ferulic acid and
Half terpenoid, possibly together with VitAVitE, volatile oil, arginine and several mineral materials.Tool
Some effects are as follows with effect: can remarkably promote body hemopoietic function, raise erythrocyte, leukocyte and blood red egg
Bai Hanliang；Suppression platelet aggregation, antithrombotic, regulate blood fat；Resist myocardial ischemia, arrhythmia, expand blood
Pipe, reduces blood pressure；Replenishing and activating blood, hepatoprotective are dirty, prevent hepatic glycogen from reducing, and reduce blood glucose；Strengthen immunity, resist
Scorching, protect the liver, radioprotective, antioxidation and removing free radical etc..It addition, uterine smooth muscle can also be regulated.
Ginkgetin be from the leaf of " living fossil " ginkgo extract, be highly resistant to and prevent computer,
The infringement that human body is caused by the electromagnetic radiation such as mobile phone, the particularly protective effect to brain cell are obvious, also have
There is rubbish in vessel softening, removing blood, drop the effect such as three fat, removing free radical.
Tea polyphenols is extracting directly from a tender leaf of sieve tea and spring bud, has the strongest Scavenger of ROS and freedom
The effects such as base, control oxidase, elimination halitosis, protection vision.
Stevioside extracts from natural Stevia leaves, is a kind of to have high sugariness, crude sweet low in calories
Taste agent.It is eaten for a long time and people will not be made to get fat, and have certain regulation blood glucose function stevioside to have no side effect,
Non-carcinogenesis, noresidue, safe and reliable, the most edible can the disease such as prophylaxis of hypertension, heart disease, dental caries,
It is particularly well-suited to diabetics, phenyl ketonuria patient and the health care of obese people.Stevioside is current
The world it has been found that and through China's Ministry of Public Health, Ministry of Light Industry approval use the natural low grade fever closest to sucrose taste
Value sweeting agent, is that have Development volue and the healthy natural sucrose praised highly outside cane suger and beet sugar that continue replaces
Product, are described as " third place in the world sucrose ".
The method have the advantages that
(1) xanthan gum in the present invention, guar gum, locust bean gum, locust bean gum, can play thickening, hang
Floating effect, improves mouthfeel, makes mouthfeel smooth, improves the quality of blood sugar lowering Folium Ginkgo tea；
(2) present invention uses inosinic acid potassium, guanyl potassium, delicate flavour can be made to increase several times, make blood sugar lowering Semen Ginkgo
Tea has strong natural flavor；
(3) present invention uses cosolvent, the dissolving of the most each composition, makes solution mix homogeneously；
(4) present invention uses dispersant, and system can be made uniform, and suspendability increases, and does not precipitates, makes whole
System physico-chemical property is the same；
(5) present invention uses antioxidant, it is to avoid the materials such as tea polyphenols lose during preparing blood sugar lowering Folium Ginkgo tea
Deactivation；
(6) present invention uses that abnormal flavour in blood sugar lowering Folium Ginkgo tea covered by flavouring agent, to improve blood sugar lowering Folium Ginkgo tea agreeable to the taste
Property；
(7) present invention extracts ginkgetin rate and active component is high, and technique is simple, with short production cycle；
(8) tea polyphenols activity and the extract impurity content that prepared by the present invention are high；
(9) in stevioside's purification of the present invention and decolorization, seriality is good, and resin and reagent dosage are little, tree
Fat utilization rate is high, operates the shortest；
(10) Folium Ginkgo tea of the present invention have the effects such as blood sugar lowering, make that beverage mouthfeel is good, taste is aromatic；
(11) compared with the Folium Ginkgo tea of traditional handicraft, the problems such as de-bitter detoxification are fully achieved, safely and effectively
The benefit of Semen Ginkgo is performed to ultimate attainment；
(12) the blood sugar lowering Folium Ginkgo tea of the present invention refine essence without any preservative and pigment, pure natural plant
China, breaches cold water and makes tea technology, utilize low-temperature extraction technology, it is ensured that the active component in plant is by broken
Bad, easily it is absorbed by the body after drinking, it is readily soluble and is easily solved the short slab of traditional product by absorption；
(13) the blood sugar lowering Folium Ginkgo tea frozen water of the present invention, cold water, brewed in hot water even can, unique flavor, convenient
Drinking of each age level.
[detailed description of the invention]
For ease of being more fully understood that the present invention, being illustrated by following instance, these examples belong to the present invention's
Protection domain, but it is not intended to protection scope of the present invention.
In an embodiment, blood sugar lowering Folium Ginkgo tea, in units of weight portion, including following raw material: Fructus Momordicae charantiae 150-350
Part, Fructus Lycii 150-350 part, Rhizoma Atractylodis Macrocephalae 150-350 part, Rhizoma Polygonati Odorati 80-160 part, Radix Paeoniae Rubra 80-160 part, Pueraria lobota
Root 60-80 part, Radix Angelicae Sinensis 60-80 part, malt extract stick with paste 30-60 part, ginkgetin 1-3 part, tea polyphenols 1-3
Part, stevioside's 1-3 part, vitamin 1-3 part, thickening agent 0.8-2 part, cosolvent 0.8-2 part, dispersant
0.8-2 part, antioxidant 0.8-2 part, tasty agents 0.5-1.5 part, flavouring agent 0.5-1.5 part；
Described vitamin includes the one in vitamin A, vitamin C, vitamin D and vitamin E or many
Kind；
Described thickening agent includes one or more in xanthan gum, guar gum, locust bean gum and locust bean gum；
Described cosolvent is polyvinylpyrrolidone；
Described dispersant includes following component: potassium carboxymethylcellulose, agar, modified starch, polyacrylic acid potassium
With one or more of potassium alginate；
Described antioxidant includes that food grade antioxidant 9701, food grade antioxidant BHT, food grade antioxidant are different
One or more in VC potassium, food grade antioxidant BHA and food grade antioxidant MSK-NE150；
Described tasty agents includes one or more in inosinic acid potassium and guanyl potassium；
Described flavouring agent is methyl cyclopentenyl ketone；
The preparation method of described blood sugar lowering Folium Ginkgo tea, comprises the following steps:
S1: pulverize after Fructus Momordicae charantiae, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Odorati, Radix Paeoniae Rubra, Radix Puerariae and Radix Angelicae Sinensis are respectively dried, mistake
40-60 mesh sieve, puts in ultrasonic extraction equipment, carries after adding 2000-7000 part abundant moistening of water water
Taking, the condition of extraction is: ultrasonic power is 120-180W, and Extracting temperature is 40-70 DEG C, and extraction time is
30-60min；
S2: step S1 is extracted medical filtration, is sequentially added into ginkgetin, tea polyphenols, Folium Stevlae Rebaudianae after puckery
Glycoside, vitamin, thickening agent, cosolvent, dispersant, antioxidant, tasty agents, flavouring agent, at rotating speed be
Stirring 1-3min under 200-500r/min, be uniformly mixed liquid, concentrates the filtrate to temperature when being 64-66 DEG C
Relative density is the clear paste of 1.32-1.38；
S3: the clear paste of step S2 is spray-dried to water content≤6% at temperature 200-220 DEG C, after pulverizing
Cross the sieve of 200-400 mesh, prepare powder；
S4: the powder of step S3 and malt extract are stuck with paste, 50-100 part water uses pelletize mechanism after being sufficiently mixed
Becoming granule, finally prepared described granule is 134-136 DEG C in temperature, pressure is 210-230KPa,
Time is sterilizing under 20-40s, obtains blood sugar lowering Folium Ginkgo tea；
The preparation method of ginkgetin described in step S2 comprises the following steps:
(1) carry out pulverizing and cross 40-80 mesh sieve by dry Folium Ginkgo, prepare Ginkgo Leaf；
(2) water of 38-62 DEG C is used to extract the Ginkgo Leaf that step 1 prepares, solid-to-liquid ratio in extraction
For 1:12-14 (W/V), extraction time is 2.5-3.5h, extracts 2-3 time, filtration, merging filtrate after extraction,
Prepare mixing lixiviating solution；
(3) mixing lixiviating solution concentrate drying step 2 prepared, prepares extraction cream, is used in extraction cream 5.5-6
The water of 45-55 DEG C of times volume dissolves, and uses anhydrous ethyl acetate solvent to carry out extraction 2-3 time, continuation
Carrying out repeatedly crystallization treatment with anhydrous ethyl acetate, in crystallization process, solid-to-liquid ratio is 1:5.2-5.4 (W/V), system
Obtain crystal crude product；
(4) crystal crude product step 3 prepared is through supercritical CO2Extraction, the condition of extraction: extraction kettle
Pressure is 12-18MPa, and extraction temperature is 42-45 DEG C, and extraction time is 32-40min, prepares ginkgetin；
The preparation method of tea polyphenols described in step S2 comprises the following steps:
A () will cross 40-80 mesh sieve after group's sieve tea pulverizing, be the ethanol water of 40%-60% with mass fraction
Mix for 1:16-20 in mass ratio, extract 2-3 time at temperature is 36-40 DEG C, each 20-30min, mistake
Filter, merging filtrate, concentrate, prepare tea polyphenols crude extract；
(b) by step a prepare tea polyphenols crude extract join in KCl solution, pH regulator to 6.8-7.2,
Under centrifugal rotational speed is 4000-4500r/min, removes impurity, uses 0.45 μm filter membrane to be 34-36 DEG C in temperature
Under the solution after centrifugal is filtered, prepare filtrate；
C filtrate ether extraction that step b is prepared by (), freezing, prepare tea polyphenols after drying；
The preparation method of stevioside described in step S2 comprises the following steps:
(A) being dipped in water immersion 1-1.2.h after being pulverized by Stevia leaves, solid-to-liquid ratio is 1:20-25 (W/V),
Being 100-120W at ultrasonic power, Extracting temperature is 40-60 DEG C, and extraction time is to extract under 20-30min,
Prepare Folium Stevlae Rebaudianae medicinal liquid；
(B) the Folium Stevlae Rebaudianae medicinal liquid that step A prepares is crossed the filter cloth of 120-180 mesh, prepares Folium Stevlae Rebaudianae filtrate；
(C) the Folium Stevlae Rebaudianae filtrate prepared to step B adds the NaAl of filtrate percentage by weight 0.8%-1%
(SO4)2Ca (OH) with filtrate percentage by weight 1%-1.4%2, tune pH value is 6.8-7.2,
At temperature 44-48 DEG C, stand 3.2-3.5h, prepare the solution after the removal of impurity；
(D) containing sweetleaf during the solution filter after removal of impurity step C prepared is filtered and concentrated to every milliliter
Chrysanthemum glycoside 10%-25%, uses macroporous adsorbent resin ADS-8 separating-purifying to prepare the liquid of stevioside, condition
For: resolving agent is the ethanol solution of 55%-65%, and its consumption is 1-3 times of macroporous adsorbent resin volume, water
Washing district is deionized water, and absorption with macroporous adsorbent resin regenerated solvent is the KOH solution of 2%-4%, and adsorption zone is flowed
Speed 6-10BV/h, desorption zone flow velocity 15-20BV/h, water wash zone flow velocity 20-25BV/h, renewing zone flow velocity
6-8BV/h, switching time is 700-750s, and temperature is 40-50 DEG C, and pressure is 0.4-0.9MPa；
(E) stevioside's liquid that step D prepares is concentrated, carry out at temperature is 200-220 DEG C
It is spray-dried, prepares stevioside.
Below by more specifically embodiment, the present invention will be described.
Embodiment 1
A kind of blood sugar lowering Folium Ginkgo tea, in units of weight portion, including following raw material: 250 parts of Fructus Momordicae charantiae, Fructus Lycii
250 parts, the Rhizoma Atractylodis Macrocephalae 250 parts, Rhizoma Polygonati Odorati 120 parts, Radix Paeoniae Rubra 120 parts, Radix Puerariae 70 parts, Radix Angelicae Sinensis 70 parts, Fructus Hordei Germinatus
Essence paste 50 parts, ginkgetin 2 parts, tea polyphenols 2 parts, stevioside 2 parts, vitamin 2 parts, thickening agent
1.5 parts, cosolvent 1.5 parts, dispersant 1.5 parts, 1.5 parts of antioxidant, tasty agents 1 part, flavouring agent 1 part；
Described vitamin is vitamin A, vitamin C, vitamin D, vitamin E；
Described thickening agent is xanthan gum, guar gum, locust bean gum, locust bean gum；
Described cosolvent is polyvinylpyrrolidone；
Described dispersant consists of the following composition: potassium carboxymethylcellulose, agar, modified starch；
Described antioxidant is food grade antioxidant different VC potassium, food grade antioxidant BHA, food grade antioxidant
MSK-NE150；
Described tasty agents is inosinic acid potassium, guanyl potassium；
Described flavouring agent is methyl cyclopentenyl ketone；
The preparation method of described blood sugar lowering Folium Ginkgo tea, comprises the following steps:
S1: by Fructus Momordicae charantiae；Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Odorati, Radix Paeoniae Rubra, Radix Puerariae, Radix Angelicae Sinensis, be respectively dried after pulverize,
Cross 60 mesh sieves, put in ultrasonic extraction equipment, extract after adding 5000 parts of abundant moistenings of water, extract
Condition be: ultrasonic power is 150W, and Extracting temperature is 100 DEG C, and extraction time is 50min；
S2: step S1 is extracted medical filtration, except add after puckery ginkgetin, tea polyphenols, stevioside,
Vitamin, thickening agent, cosolvent, dispersant, antioxidant, tasty agents, flavouring agent, be 300r/min at rotating speed
Lower stirring 2min, be uniformly mixed liquid, and concentrating the filtrate to relative density when temperature is 65 DEG C is 1.35
Clear paste；
S3: being spray-dried at 210 DEG C by the clear paste of step S2 to water content is 5%, crosses 300 mesh after pulverizing
Sieve, prepare powder；
S4: stuck with paste with malt extract by the powder of step S3,80 parts of water mix and make granule, finally system
The described granule obtained is 135 DEG C in temperature, and pressure is 220KPa, and the time is sterilizing under 30s, prepares fall blood
Sugar Folium Ginkgo tea；
The preparation method of ginkgetin described in step S2 comprises the following steps:
(1) carry out pulverizing and cross 60 mesh sieve by dry Folium Ginkgo, prepare Ginkgo Leaf；
(2) using the water of 50 DEG C to extract the Ginkgo Leaf that step 1 prepares, in extraction, solid-to-liquid ratio is
1:13 (W/V), extraction time is 3h, extracts 2 times, filtration, merging filtrate after extraction, prepares mixing leaching
Extract；
(3) mixing lixiviating solution concentrate drying step 2 prepared, prepares extraction cream, is used in extraction cream 5.8
The water of 50 DEG C of times volume dissolves, and uses anhydrous ethyl acetate solvent to carry out extracting 2 times, continues to use nothing
Water ethyl acetate carries out repeatedly crystallization treatment, and in crystallization process, solid-to-liquid ratio is 1:5.3 (W/V), prepares crystallization
Crude product；
(4) crystal crude product step 3 prepared is through supercritical CO2Extraction, the condition of extraction: extraction kettle
Pressure is 15MPa, and extraction temperature is 43 DEG C, and extraction time is 36min, prepares ginkgetin；
The preparation method of tea polyphenols described in step S2 comprises the following steps:
A () will cross 60 mesh sieves, with the ethanol water that mass fraction is 50% in mass ratio after group's sieve tea pulverizing
Mix for 1:18, extract 2 times at temperature is 38 DEG C, each 25min, filter, merging filtrate, concentrate,
Prepare tea polyphenols crude extract；
B the tea polyphenols crude extract that step a prepares is joined in KCl solution by (), pH regulator to 7,
Centrifugal rotational speed is removing impurity under 4200r/min, after using 0.45 μm filter membrane to being centrifuged at temperature is 35 DEG C
Solution filter, prepare filtrate；
C filtrate ether extraction that step b is prepared by (), freezing, prepare tea polyphenols after drying；
The preparation method of stevioside described in step S2 comprises the following steps:
(A) being dipped in water immersion 1.1h after being pulverized by Stevia leaves, solid-to-liquid ratio is 1:22 (W/V),
Ultrasonic power is 110W, and Extracting temperature is 50 DEG C, and extraction time is to extract under 25min, prepares Folium Stevlae Rebaudianae
Medicinal liquid；
(B) the Folium Stevlae Rebaudianae medicinal liquid that step A prepares is crossed the filter cloth of 150 mesh, prepares Folium Stevlae Rebaudianae filtrate；
(C) the Folium Stevlae Rebaudianae filtrate prepared to step B adds the NaAl of filtrate percentage by weight 0.9%
(SO4)2Ca (OH) with filtrate percentage by weight 1.2%2, adjusting pH value is 7, temperature 46 DEG C
Under, stand 3.3h, prepare the solution after the removal of impurity；
(D) containing sweetleaf during the solution filter after removal of impurity step C prepared is filtered and concentrated to every milliliter
Chrysanthemum glycoside 32%, uses macroporous adsorbent resin ADS-8 separating-purifying to prepare the liquid of stevioside, and condition is:
Resolve agent be the ethanol solution of 60%, its consumption is 2 times of macroporous adsorbent resin volume, water wash zone for go from
Sub-water, absorption with macroporous adsorbent resin regenerated solvent is the KOH solution of 3%, adsorption zone flow velocity 8BV/h, solves
Inhaling district flow velocity 18BV/h, water wash zone flow velocity 22BV/h, renewing zone flow velocity 7BV/h, switching time is 720s,
Temperature is 45 DEG C, and pressure is 0.7MPa；
(E) stevioside's liquid that step D prepares is concentrated, spray at temperature is 210 DEG C
It is dried, prepares stevioside.
Embodiment 2
A kind of blood sugar lowering Folium Ginkgo tea, in units of weight portion, including following raw material: 150 parts of Fructus Momordicae charantiae, Fructus Lycii
150 parts, the Rhizoma Atractylodis Macrocephalae 150 parts, Rhizoma Polygonati Odorati 80 parts, Radix Paeoniae Rubra 80 parts, Radix Puerariae 60 parts, Radix Angelicae Sinensis 60 parts, malt extract
Stick with paste 30 parts, ginkgetin 1 part, tea polyphenols 1 part, stevioside 1 part, vitamin 1 part, thickening agent 0.8
Part, cosolvent 0.8 part, dispersant 0.8 part, 0.8 part of antioxidant, tasty agents 0.5 part, flavouring agent 0.5 part；
Described vitamin is vitamin；
Described thickening agent is xanthan gum；
Described cosolvent is polyvinylpyrrolidone；
Described dispersant consists of the following composition: modified starch, polyacrylic acid potassium and potassium alginate；
Described antioxidant is food grade antioxidant 9701；
Described tasty agents is inosinic acid potassium；
Described flavouring agent is methyl cyclopentenyl ketone；
The preparation method of described blood sugar lowering Folium Ginkgo tea, comprises the following steps:
S1: by Fructus Momordicae charantiae；Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Odorati, Radix Paeoniae Rubra, Radix Puerariae, Radix Angelicae Sinensis, be respectively dried after pulverize,
Cross 40 mesh sieves, put in ultrasonic extraction equipment, extract after adding 2000 parts of abundant moistenings of water, extract
Condition be: ultrasonic power is 120W, and Extracting temperature is 40 DEG C, and extraction time is 60min；
S2: step S1 is extracted medical filtration, except add after puckery ginkgetin, tea polyphenols, stevioside,
Vitamin, thickening agent, cosolvent, dispersant, antioxidant, tasty agents, flavouring agent, be 200r/min at rotating speed
Lower stirring 3min, be uniformly mixed liquid, and concentrating the filtrate to relative density when temperature is 64 DEG C is 1.32
Clear paste；
S3: being spray-dried at 200 DEG C by the clear paste of step S2 to water content is 6%, crosses 200 mesh after pulverizing
Sieve, prepare powder；
S4: stuck with paste with malt extract by the powder of step S3,50 parts of water mix and make granule, finally system
The described granule obtained is 134 DEG C in temperature, and pressure is 210KPa, and the time is sterilizing under 40s, prepares fall blood
Sugar Folium Ginkgo tea；
The preparation method of ginkgetin described in step S2 comprises the following steps:
(1) carry out pulverizing and cross 40 mesh sieve by dry Folium Ginkgo, prepare Ginkgo Leaf；
(2) using the water of 38 DEG C to extract the Ginkgo Leaf that step 1 prepares, in extraction, solid-to-liquid ratio is
1:12 (W/V), extraction time is 3.5h, extracts 2 times, filtration, merging filtrate after extraction, prepares mixing
Lixiviating solution；
(3) mixing lixiviating solution concentrate drying step 2 prepared, prepares extraction cream, is used in extraction cream 5.5
The water of 45 DEG C of times volume dissolves, and uses anhydrous ethyl acetate solvent to carry out extracting 2 times, continues to use nothing
Water ethyl acetate carries out repeatedly crystallization treatment, and in crystallization process, solid-to-liquid ratio is 1:5.2 (W/V), prepares crystallization
Crude product；
(4) crystal crude product step 3 prepared is through supercritical CO2Extraction, the condition of extraction: extraction kettle
Pressure is 12MPa, and extraction temperature is 42 DEG C, and extraction time is 40min, prepares ginkgetin；
The preparation method of tea polyphenols described in step S2 comprises the following steps:
A () will cross 40 mesh sieves, with the ethanol water that mass fraction is 40% in mass ratio after group's sieve tea pulverizing
Mix for 1:16, extract 2 times at temperature is 36 DEG C, each 30min, filter, merging filtrate, concentrate,
Prepare tea polyphenols crude extract；
B the tea polyphenols crude extract that step a prepares is joined in KCl solution by (), pH regulator to 6.8,
Under centrifugal rotational speed is 4000-/min, removes impurity, uses 0.45 μm filter membrane to centrifugal at temperature is 34 DEG C
After solution filter, prepare filtrate；
C filtrate ether extraction that step b is prepared by (), freezing, prepare tea polyphenols after drying；
The preparation method of stevioside described in step S2 comprises the following steps:
(A) being dipped in water immersion 1h after being pulverized by Stevia leaves, solid-to-liquid ratio is 1:20 (W/V), super
Acoustic power is 100W, and Extracting temperature is 40 DEG C, and extraction time is to extract under 30min, prepares Folium Stevlae Rebaudianae medicine
Liquid；
(B) the Folium Stevlae Rebaudianae medicinal liquid that step A prepares is crossed the filter cloth of 120 mesh, prepares Folium Stevlae Rebaudianae filtrate；
(C) the Folium Stevlae Rebaudianae filtrate prepared to step B adds the NaAl of filtrate percentage by weight 0.8%
(SO4)2Ca (OH) with filtrate percentage by weight 1%2, adjusting pH value is 6.8, temperature 44 DEG C
Under, stand 3.2-3.5h, prepare the solution after the removal of impurity；
(D) containing sweetleaf during the solution filter after removal of impurity step C prepared is filtered and concentrated to every milliliter
Chrysanthemum glycoside 10%, uses macroporous adsorbent resin ADS-8 separating-purifying to prepare the liquid of stevioside, and condition is:
Resolving agent is the ethanol solution of 55%, and its consumption is 1 times of macroporous adsorbent resin volume, and water wash zone is deionization
Water, absorption with macroporous adsorbent resin regenerated solvent is the KOH solution of 2%, adsorption zone flow velocity 6BV/h, desorbing
District flow velocity 15BV/h, water wash zone flow velocity 20BV/h, renewing zone flow velocity 6BV/h, switching time is 700s, temperature
Degree is 40 DEG C, and pressure is 0.4MPa；
(E) stevioside's liquid that step D prepares is concentrated, spray at temperature is 200 DEG C
It is dried, prepares stevioside.
Embodiment 3
A kind of blood sugar lowering Folium Ginkgo tea, in units of weight portion, including following raw material: 350 parts of Fructus Momordicae charantiae, Fructus Lycii
350 parts, the Rhizoma Atractylodis Macrocephalae 350 parts, Rhizoma Polygonati Odorati 160 parts, Radix Paeoniae Rubra 160 parts, Radix Puerariae 80 parts, Radix Angelicae Sinensis 80 parts, Fructus Hordei Germinatus
Essence paste 60 parts, ginkgetin 3 parts, tea polyphenols 3 parts, stevioside 3 parts, vitamin 3 parts, thickening agent
2 parts, cosolvent 2 parts, dispersant 2 parts, 2 parts of antioxidant, tasty agents 1.5 parts, fragrance 1.5 parts；
Described vitamin is vitamin C；
Described thickening agent is guar gum；
Described cosolvent is polyvinylpyrrolidone；
Described dispersant consists of the following composition: potassium carboxymethylcellulose, modified starch, potassium alginate；
Described antioxidant is food grade antioxidant BHT；
Described tasty agents is inosinic acid potassium；
Described flavouring agent is methyl cyclopentenyl ketone；
The preparation method of described blood sugar lowering Folium Ginkgo tea, comprises the following steps:
S1: by Fructus Momordicae charantiae；Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Odorati, Radix Paeoniae Rubra, Radix Puerariae, Radix Angelicae Sinensis are pulverized after being respectively dried, mistake
60 mesh sieves, put in ultrasonic extraction equipment, extract after adding 7000 parts of abundant moistenings of water, extraction
Condition is: ultrasonic power is 180W, and Extracting temperature is 70 DEG C, and extraction time is 30min；
S2: step S1 is extracted medical filtration, except add after puckery ginkgetin, tea polyphenols, stevioside,
Vitamin, thickening agent, cosolvent, dispersant, antioxidant, tasty agents, flavouring agent, be 500r/min at rotating speed
Lower stirring 1min, be uniformly mixed liquid, and concentrating the filtrate to relative density when temperature is 66 DEG C is 1.38
Clear paste；
S3: being spray-dried at 220 DEG C by the clear paste of step S2 to water content is 4%, crosses 400 mesh after pulverizing
Sieve, prepare powder；
S4: stuck with paste with malt extract by the powder of step S3,100 parts of water mix and make granule, finally handle
The described granule prepared is 136 DEG C in temperature, and pressure is 230KPa, and the time is sterilizing under 40s, prepares fall
Blood glucose Folium Ginkgo tea；
The preparation method of ginkgetin described in step S2 comprises the following steps:
(1) carry out pulverizing and cross 80 mesh sieve by dry Folium Ginkgo, prepare Ginkgo Leaf；
(2) using the water of 62 DEG C to extract the Ginkgo Leaf that step 1 prepares, in extraction, solid-to-liquid ratio is
1:14 (W/V), extraction time is 2.5h, extracts 3 times, filtration, merging filtrate after extraction, prepares mixing
Lixiviating solution；
(3) mixing lixiviating solution concentrate drying step 2 prepared, prepares extraction cream, is used in extraction cream 6 times
The water of 55 DEG C of volume dissolves, and uses anhydrous ethyl acetate solvent to carry out extracting 3 times, continues with anhydrous
Ethyl acetate carries out repeatedly crystallization treatment, and in crystallization process, solid-to-liquid ratio is 1:5.4 (W/V), prepares crystallization thick
Product；
(4) crystal crude product step 3 prepared is through supercritical CO2Extraction, the condition of extraction: extraction kettle
Pressure is 18MPa, and extraction temperature is 45 DEG C, and extraction time is 32min, prepares ginkgetin；
The preparation method of tea polyphenols described in step S2 comprises the following steps:
A () will cross 80 mesh sieves, with the ethanol water that mass fraction is 60% in mass ratio after group's sieve tea pulverizing
Mix for 1:20, extract 3 times at temperature is 40 DEG C, each 20min, filter, merging filtrate, concentrate,
Prepare tea polyphenols crude extract；
B the tea polyphenols crude extract that step a prepares is joined in KCl solution by (), pH regulator to 7.2,
Under centrifugal rotational speed is 4500r/min, removes impurity, uses 0.45 μm filter membrane to centrifugal at temperature is 36 DEG C
After solution filter, prepare filtrate；
C filtrate ether extraction that step b is prepared by (), freezing, prepare tea polyphenols after drying；
The preparation method of stevioside described in step S2 comprises the following steps:
(A) being dipped in water immersion 1.2h after being pulverized by Stevia leaves, solid-to-liquid ratio is 1:25 (W/V),
Ultrasonic power is 120W, and Extracting temperature is 60 DEG C, and extraction time is to extract under 20min, prepares Folium Stevlae Rebaudianae
Medicinal liquid；
(B) the Folium Stevlae Rebaudianae medicinal liquid that step A prepares is crossed the filter cloth of 180 mesh, prepares Folium Stevlae Rebaudianae filtrate；
(C) the Folium Stevlae Rebaudianae filtrate prepared to step B adds the NaAl (SO of filtrate percentage by weight 1%4)2Ca (OH) with filtrate percentage by weight 1.4%2, adjusting pH value is 7.2, at temperature 48 DEG C, quiet
Put 3.2-3.5h, prepare the solution after the removal of impurity；
(D) containing sweetleaf during the solution filter after removal of impurity step C prepared is filtered and concentrated to every milliliter
Chrysanthemum glycoside 25%, uses macroporous adsorbent resin ADS-8 separating-purifying to prepare the liquid of stevioside, and condition is:
Resolve agent be the ethanol solution of 65%, its consumption is 3 times of macroporous adsorbent resin volume, water wash zone for go from
Sub-water, absorption with macroporous adsorbent resin regenerated solvent is the KOH solution of 4%, adsorption zone flow velocity 10BV/h, solves
Inhaling district flow velocity 20BV/h, water wash zone flow velocity 25BV/h, renewing zone flow velocity 8BV/h, switching time is 750s,
Temperature is 50 DEG C, and pressure is 0.9MPa；
(E) stevioside's liquid that step D prepares is concentrated, spray at temperature is 220 DEG C
It is dried, prepares stevioside.
Above content it cannot be assumed that the present invention be embodied as be confined to these explanation, for skill belonging to the present invention
For the those of ordinary skill in art field, without departing from the inventive concept of the premise, it is also possible to make some letters
Single deduction or replace, all should be considered as belonging to the patent protection model that the present invention is determined by the claims submitted to
Enclose.
Claims (8)
1. blood sugar lowering Folium Ginkgo tea, it is characterised in that in units of weight portion, including following raw material: Fructus Momordicae charantiae
150-350 part, Fructus Lycii 150-350 part, Rhizoma Atractylodis Macrocephalae 150-350 part, Rhizoma Polygonati Odorati 80-160 part, Radix Paeoniae Rubra 80-160
It is many that part, Radix Puerariae 60-80 part, Radix Angelicae Sinensis 60-80 part, malt extract stick with paste 30-60 part, ginkgetin 1-3 part, tea
Phenol 1-3 part, stevioside's 1-3 part, vitamin 1-3 part, thickening agent 0.8-2 part, cosolvent 0.8-2 part,
Dispersant 0.8-2 part, antioxidant 0.8-2 part, tasty agents 0.5-1.5 part, flavouring agent 0.5-1.5 part；
The preparation method of described blood sugar lowering Folium Ginkgo tea, comprises the following steps:
S1: pulverize after Fructus Momordicae charantiae, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati Odorati, Radix Paeoniae Rubra, Radix Puerariae, Radix Angelicae Sinensis are respectively dried, mistake
40-60 mesh sieve, puts in ultrasonic extraction equipment, extracts after adding the 2000-7000 abundant moistening of part water
Medicinal liquid, the condition of extraction is: ultrasonic power is 120-180W, and Extracting temperature is 40-70 DEG C, extraction time
For 30-60min；
S2: step S1 is extracted medical filtration, is sequentially added into ginkgetin, tea polyphenols, Folium Stevlae Rebaudianae after puckery
Glycoside, vitamin, thickening agent, cosolvent, dispersant, antioxidant, tasty agents, flavouring agent, at rotating speed be
Stirring 1-3min under 200-500r/min, be uniformly mixed liquid, concentrates the filtrate to temperature when being 64-66 DEG C
Relative density is the clear paste of 1.32-1.38；
S3: the clear paste of step S2 is spray-dried to water content≤6% at temperature 200-220 DEG C, after pulverizing
Cross the sieve of 200-400 mesh, prepare powder；
S4: the powder of step S3 and malt extract are stuck with paste, 50-100 part water uses pelletize mechanism after being sufficiently mixed
Becoming granule, finally prepared described granule is 134-136 DEG C in temperature, pressure is 210-230KPa,
Time is sterilizing under 20-40s, obtains blood sugar lowering Folium Ginkgo tea；
The preparation method of ginkgetin described in step S2 comprises the following steps:
(1) carry out pulverizing and cross 40-80 mesh sieve by dry Folium Ginkgo, prepare Ginkgo Leaf；
(2) water of 38-62 DEG C is used to extract the Ginkgo Leaf that step 1 prepares, solid-to-liquid ratio in extraction
For 1:12-14 (W/V), extraction time is 2.5-3.5h, extracts 2-3 time, filtration, merging filtrate after extraction,
Prepare mixing lixiviating solution；
(3) mixing lixiviating solution concentrate drying step 2 prepared, prepares extraction cream, is used in extraction cream 5.5-6
The water of 45-55 DEG C of times volume dissolves, and uses anhydrous ethyl acetate solvent to carry out extraction 2-3 time, continuation
Carrying out repeatedly crystallization treatment with anhydrous ethyl acetate, in crystallization process, solid-to-liquid ratio is 1:5.2-5.4 (W/V), system
Obtain crystal crude product；
(4) crystal crude product step 3 prepared is through supercritical CO2Extraction, the condition of extraction: extraction kettle
Pressure is 12-18MPa, and extraction temperature is 42-45 DEG C, and extraction time is 32-40min, prepares ginkgetin；
The preparation method of tea polyphenols described in step S2 comprises the following steps:
A () will cross 40-80 mesh sieve after group's sieve tea pulverizing, be the ethanol water of 40%-60% with mass fraction
Mix for 1:16-20 in mass ratio, extract 2-3 time at temperature is 36-40 DEG C, each 20-30min, mistake
Filter, merging filtrate, concentrate, prepare tea polyphenols crude extract；
(b) by step a prepare tea polyphenols crude extract join in KCl solution, pH regulator to 6.8-7.2,
Under centrifugal rotational speed is 4000-4500r/min, removes impurity, uses 0.45 μm filter membrane to be 34-36 DEG C in temperature
Under the solution after centrifugal is filtered, prepare filtrate；
C filtrate ether extraction that step b is prepared by (), freezing, prepare tea polyphenols after drying；
The preparation method of stevioside described in step S2 comprises the following steps:
(A) being dipped in water immersion 1-1.2.h after being pulverized by Stevia leaves, solid-to-liquid ratio is 1:20-25 (W/V),
Being 100-120W at ultrasonic power, Extracting temperature is 40-60 DEG C, and extraction time is to extract under 20-30min,
Prepare Folium Stevlae Rebaudianae medicinal liquid；
(B) the Folium Stevlae Rebaudianae medicinal liquid that step A prepares is crossed the filter cloth of 120-180 mesh, prepares Folium Stevlae Rebaudianae filtrate；
(C) the Folium Stevlae Rebaudianae filtrate prepared to step B adds the NaAl of filtrate percentage by weight 0.8%-1%
(SO4)2Ca (OH) with filtrate percentage by weight 1%-1.4%2, tune pH value is 6.8-7.2,
At temperature 44-48 DEG C, stand 3.2-3.5h, prepare the solution after the removal of impurity；
(D) containing sweetleaf during the solution filter after removal of impurity step C prepared is filtered and concentrated to every milliliter
Chrysanthemum glycoside 10%-25%, uses macroporous adsorbent resin ADS-8 separating-purifying to prepare the liquid of stevioside, condition
For: resolving agent is the ethanol solution of 55%-65%, and its consumption is 1-3 times of macroporous adsorbent resin volume, water
Washing district is deionized water, and absorption with macroporous adsorbent resin regenerated solvent is the KOH solution of 2%-4%, and adsorption zone is flowed
Speed 6-10BV/h, desorption zone flow velocity 15-20BV/h, water wash zone flow velocity 20-25BV/h, renewing zone flow velocity
6-8BV/h, switching time is 700-750s, and temperature is 40-50 DEG C, and pressure is 0.4-0.9MPa；
(E) stevioside's liquid that step D prepares is concentrated, carry out at temperature is 200-220 DEG C
It is spray-dried, prepares stevioside.
Blood sugar lowering Folium Ginkgo tea the most according to claim 1, it is characterised in that described vitamin includes vitamin
One or more in A, vitamin C, vitamin D and vitamin E.
Blood sugar lowering Folium Ginkgo tea the most according to claim 1, it is characterised in that described thickening agent include xanthan gum,
One or more in guar gum, locust bean gum and locust bean gum.
Blood sugar lowering Folium Ginkgo tea the most according to claim 1, it is characterised in that described cosolvent is polyethylene pyrrole
Pyrrolidone.
Blood sugar lowering Folium Ginkgo tea the most according to claim 1, it is characterised in that described dispersant includes following one-tenth
Point: one or more in potassium carboxymethylcellulose, agar, modified starch, polyacrylic acid potassium and potassium alginate.
Blood sugar lowering Folium Ginkgo tea the most according to claim 1, it is characterised in that described antioxidant includes food stage
Antioxidant 9701, food grade antioxidant BHT, food grade antioxidant different VC potassium, food grade antioxidant BHA
With one or more in food grade antioxidant MSK-NE150.
Blood sugar lowering Folium Ginkgo tea the most according to claim 1, it is characterised in that described tasty agents includes inosinic acid
One or more in potassium and guanyl potassium.
Blood sugar lowering Folium Ginkgo tea the most according to claim 1, it is characterised in that described flavouring agent is methyl ring penta
Enol ketone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610317413.1A CN105918559A (en) | 2016-05-12 | 2016-05-12 | Ginkgo tea capable of reducing blood sugar |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610317413.1A CN105918559A (en) | 2016-05-12 | 2016-05-12 | Ginkgo tea capable of reducing blood sugar |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081325A (en) * | 1992-07-18 | 1994-02-02 | 杨光福 | The compound method of a kind of health protection tea |
| CN101717418A (en) * | 2009-12-10 | 2010-06-02 | 黑龙江省农产品加工工程技术研究中心 | Technology for separating stevioside in one step with simulated moving bed |
| CN104387356A (en) * | 2013-11-15 | 2015-03-04 | 广西莱吉生物工程有限公司 | Method for extracting flavone from folium ginkgo |
| CN105166235A (en) * | 2015-09-28 | 2015-12-23 | 李修田 | Qi-blood tonifying health tea capable of reducing hyperlipidemia, hypertension and hyperglycemia and preparation method thereof |
| CN105998763A (en) * | 2016-05-11 | 2016-10-12 | 繁昌县倍思创业服务有限公司 | Blood sugar reducing tea powder |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081325A (en) * | 1992-07-18 | 1994-02-02 | 杨光福 | The compound method of a kind of health protection tea |
| CN101717418A (en) * | 2009-12-10 | 2010-06-02 | 黑龙江省农产品加工工程技术研究中心 | Technology for separating stevioside in one step with simulated moving bed |
| CN104387356A (en) * | 2013-11-15 | 2015-03-04 | 广西莱吉生物工程有限公司 | Method for extracting flavone from folium ginkgo |
| CN105166235A (en) * | 2015-09-28 | 2015-12-23 | 李修田 | Qi-blood tonifying health tea capable of reducing hyperlipidemia, hypertension and hyperglycemia and preparation method thereof |
| CN105998763A (en) * | 2016-05-11 | 2016-10-12 | 繁昌县倍思创业服务有限公司 | Blood sugar reducing tea powder |
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