CN105916503B - 杂芳基化合物和其用途 - Google Patents

杂芳基化合物和其用途 Download PDF

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Publication number
CN105916503B
CN105916503B CN201580004591.2A CN201580004591A CN105916503B CN 105916503 B CN105916503 B CN 105916503B CN 201580004591 A CN201580004591 A CN 201580004591A CN 105916503 B CN105916503 B CN 105916503B
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compound
pharmaceutically acceptable
acceptable salt
group
nitrogen
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CN105916503A (zh
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因杜·T·巴拉坦
克里斯·布莱克伯恩
杰弗里·P·恰瓦利
约哈拉·舒伊塔尔
考特尼·A·卡利斯
纳塔莉·达莫雷
保罗·E·弗莱明
肯尼斯·M·吉格斯塔德
克丽斯塔·E·吉普森
马里奥·吉拉德
胡永波
贾尼丝·李
李钢
曼苏尔礼埃·雷萨依
迈克尔·D·辛乍得
弗朗索瓦·苏西
斯蒂芬·G·斯特劳德
特里西娅·J·沃斯
王楚秦
徐鹤
徐天林
叶迎春
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Takeda Pharmaceutical Co Ltd
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Millennium Pharmaceuticals Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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  • Diabetes (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580004591.2A 2014-01-14 2015-01-13 杂芳基化合物和其用途 Active CN105916503B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461927055P 2014-01-14 2014-01-14
US61/927,055 2014-01-14
US201462054742P 2014-09-24 2014-09-24
US62/054,742 2014-09-24
PCT/US2015/011191 WO2015108861A1 (en) 2014-01-14 2015-01-13 Heteroaryls and uses thereof

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CN105916503B true CN105916503B (zh) 2020-04-14

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EP (1) EP3094325B1 (enExample)
JP (1) JP6609258B2 (enExample)
KR (1) KR20160122736A (enExample)
CN (1) CN105916503B (enExample)
AP (1) AP2016009368A0 (enExample)
AU (1) AU2015206652A1 (enExample)
BR (1) BR112016016289B1 (enExample)
CA (1) CA2935867C (enExample)
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