CN105902468A - Whitening anti-aging facial cream - Google Patents

Whitening anti-aging facial cream Download PDF

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Publication number
CN105902468A
CN105902468A CN201610335992.2A CN201610335992A CN105902468A CN 105902468 A CN105902468 A CN 105902468A CN 201610335992 A CN201610335992 A CN 201610335992A CN 105902468 A CN105902468 A CN 105902468A
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Prior art keywords
aging
facial cream
prepared
whitening anti
stirring
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Pending
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CN201610335992.2A
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Chinese (zh)
Inventor
秦瑜
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Individual
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Individual
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Priority to CN201610335992.2A priority Critical patent/CN105902468A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985—Skin or skin outgrowth, e.g. hair, nails
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a whitening anti-aging facial cream which is prepared from the following raw materials: milk thistle, dendrobium nobile, linden blossom, cranberry, waste hair, shell powder, freeze-dried apple powder, allantoin, tween, span, betaine, soybean lecithin, octadecylamine, cholesterol, vaseline, anhydrous lanolin, hexadecanol, glyceryl monostearate, synanthrin, triethanolamine, glycerin, seabuckthorn seed oil, polyethylene glycol-20-cetearyl alcohol ether, polyoxyethylene hydrogenated castor oil, vitamin e, phenoxyethanol, methyl p-hydroxybenzoate and water. The facial cream disclosed by the invention has the functions of effectively removing dirt, supplementing moisture, providing nutrition to skin, delaying aging, reducing the aging speed of free radicals and recovering whiteness and vigor.

Description

A kind of facial cream of whitening anti-aging
Technical field
The present invention relates to technical field of skin care, particularly relate to the facial cream of a kind of whitening anti-aging.
Background technology
In recent years, along with expanding economy and growth in the living standard, people increasingly pay attention to the maintenance of skin, so that cosmetics quickly grow.Having and beautify and treat double effects, character causes between the functional type cosmetics of cosmetics and medicine and pays close attention to widely.Unlike Traditional makeup, functional type cosmetics should make functional components pass through horny layer as far as possible, and lasting plays nutrition, protection or therapeutical effect, less entrance blood circulation, thus improve effect local organization and cell.The method of searching promotion functions composition percutaneous absorbtion is one of key of these type of cosmetics of R and D.The skin of people is the cellularity fine and close by a layer, and cell membrane is impermeable to macromole bioactive substance.Active component nutrition to be reached in cosmetics, improve skin and effect of prevention dermatosis, it is important to active substance must be transmitted through horny layer and reaches corresponding site of action and maintain certain time.Liposome is the completely enclosed multilamellar vesicle of the bilayer formed by lipoids such as phospholipid, it is similar to that cell, water solublity and fat-soluble two kinds of materials can be encapsulated, have that targeting is efficient, slow release is controlled and the feature of safety non-toxic, but a lot of problem can be there is in liposome solutions long term storage, the seepage of such as active substance, the gathering of liposome particles and phospholipid are the most oxidized etc. under liquid condition, and these problems limit liposome application in cosmetics.
Liao Jinyan is studied mainly for ginseng aqueous extract liposome in " research of liposomal encapsulated Radix Ginseng extractive solution and the application in cosmetics thereof " literary composition, at the content measuring Radix Ginseng aqueous extract Radix Ginseng total saponins, on the basis of determining entrapment efficiency determination method and method for preparing lipidosome, Radix Ginseng aqueous extract liposome application performance in cosmetics is studied, and the particle diameter of liposome is calculated, all within 600nm, illustrate that liposome can readily penetrate skin for cosmetics, but liposome belongs to fine dispersion system, it it is thermodynamic unstable system, do not possesses good shelf characteric, period of storage length is easily subject to temperature, illumination, size, the interference of the factors such as envelop rate, thus largely effect on the character of cosmetics.The present invention, in order to ensure the stability in liposome long term storage, is prepared as freeze-dried lipidosome dosage form in conjunction with Freeze Drying Technique and is greatly improved stability, improve the quality of cosmetics.
Summary of the invention
The object of the invention is contemplated to make up the defect of prior art, it is provided that the facial cream of a kind of whitening anti-aging.
The present invention is achieved by the following technical solutions:
nullA kind of facial cream of whitening anti-aging，It is made up of the raw material of following weight portion: Milk Thistle 20-25、Herba Dendrobii flower 33-37、Tilia europaea 10-13、Cranberry 16-20、Discarded hair 40-50、Conch meal 13-15、Lyophilizing apple powder 15-18、Allantoin 0.5-0.7、Tween 80 0.15-0.2、Sorbester p17 0.1-0.15、Glycine betaine 0.6-1、Soybean lecithin 6.4-8、18-amine. 1.6-2、Cholesterol 2-3、Vaseline 3-4、Anhydrous lanolin 3-4、Hexadecanol 3-4、Glyceryl monostearate 4-5、Inulin 1-2、Triethanolamine 3-4、Glycerol 6-8、Semen Fructus Hippophae oil 2-3、Polyethylene Glycol-20-ceteareth 2-3、Polyoxyethylene hydrogenated Oleum Ricini 3-4、Vitamin e1-1.5、Phenoxyethanol 0.3-0.4、Methyl parahydroxybenzoate 0.2-0.4、Water 50-60.
The facial cream of described a kind of whitening anti-aging, is made up of step in detail below:
(1) by after Milk Thistle, Herba Dendrobii flower, Tilia europaea and cranberry co-grinding, heating extraction 1.5-2h in 75% ethanol solution, centrifugation is carried out after being cooled to room temperature, centrifugal speed is 4000-5000rpm, and centrifugation time is 10-20min, then takes its supernatant and carries out fine straining, filtrate after fine straining is concentrated to give extractum, again extractum propylene glycol is dissolved, filter, obtain the extracting solution that content is 10mg/ml standby；
(2) by discarded hair, conch meal cleans after drying and the mixing of lyophilizing apple powder adds zymocyte and ferments, fermentation temperature is 36-45 DEG C, time is 12-15h, gained fermentation liquid is carried out sterilizing again and is centrifuged, centrifugal rotational speed is 8000-12000r/min, centrifugation time is 10-20min, then collects supernatant standby；
(3) soybean lecithin, 18-amine. and cholesterol are mixed, with appropriate ether dissolution mixture, after all dissolving on Rotary Evaporators 30-35 DEG C be evaporated film forming, then take product 3.5-5ml prepared by step (1), product 2.5-4ml prepared by step (2) and appropriate pH value are the PBS of 6.8, Tween 80 and sorbester p17 is added after stirring, in ice bath, ultrasonic emulsification 40-50min obtains suspension, carry out lyophilization by suspension adding after inulin stirs, obtain lipidosome freeze-dried powder standby；
(4) vaseline, Polyethylene Glycol-20-ceteareth, hexadecanol, triethanolamine are mixed and heated to 70-75 DEG C, add glycerol, Semen Fructus Hippophae oil and water homogenisation stirring 30-35min, it is cooled to when 30-40 DEG C add remaining surplus materials stir, product prepared by step (3) is added after being cooled to room temperature, quality inspection after stirring, discharging, packs.
nullThe invention have the advantage that the present invention utilizes Milk Thistle、Herba Dendrobii flower、Tilia europaea and cranberry cooperate and use alcohol extraction to go out to have maintenance Skin Cell、Reduce endotoxins on cells infringement、Also can remove free radical、Convergence、Soft skin、Antiinflammatory、Infection、The effective ingredient of the good natural cover for defense is set up for skin，Also by discarded hair、Conch meal hydrolysed ferment together with lyophilizing apple powder goes out multiple beneficial composition，Can act on basal confluent monolayer cells，Promote that cell is the most newborn，Delay skin aging，Nutrition is provided for skin，By these several effective ingredient with liposomal encapsulated，And the 18-amine. added makes surface of liposome positively charged，The most electronegative Skin Cell compatibility is good，Good penetrability，Its bin stability is increased also by cryodesiccated method，Improve the stability of cosmetics，The facial cream of the present invention can effectively take out stains，Decompose skin melanin，Keep the skin wet，Moistening effect is good，Nutrition is provided for skin，Slow down aging，Reduce free radical aging rate，Recover tender white vigor.
Detailed description of the invention
A kind of facial cream of whitening anti-aging, it is made up of the raw material of following weight portion (kilogram): Milk Thistle 20, Herba Dendrobii spends 33, Tilia europaea 10, cranberry 16, discarded hair 40, conch meal 13, lyophilizing apple powder 15, allantoin 0.5, Tween 80 0.15, sorbester p17 0.1, glycine betaine 0.6, soybean lecithin 6.4, 18-amine. 1.6, cholesterol 2, vaseline 3, anhydrous lanolin 3, hexadecanol 3, glyceryl monostearate 4, inulin 1, triethanolamine 3, glycerol 6, Semen Fructus Hippophae oil 2, Polyethylene Glycol ceteareth 2, polyoxyethylene hydrogenated Oleum Ricini 3, vitamin e1, phenoxyethanol 0.3, methyl parahydroxybenzoate 0.2, water 50.
The facial cream of described a kind of whitening anti-aging, is made up of step in detail below:
(1) by after Milk Thistle, Herba Dendrobii flower, Tilia europaea and cranberry co-grinding, heating extraction 1.5h in 75% ethanol solution, centrifugation is carried out after being cooled to room temperature, centrifugal speed is 4000rpm, and centrifugation time is 10min, then takes its supernatant and carries out fine straining, filtrate after fine straining is concentrated to give extractum, again extractum propylene glycol is dissolved, filter, obtain the extracting solution that content is 10mg/ml standby；
(2) by discarded hair, conch meal cleans after drying and the mixing of lyophilizing apple powder adds zymocyte and ferments, and fermentation temperature is 36 DEG C, and the time is 12h, gained fermentation liquid is carried out sterilizing again and is centrifuged, centrifugal rotational speed is 8000r/min, and centrifugation time is 10min, then collects supernatant standby；
(3) soybean lecithin, 18-amine. and cholesterol are mixed, with appropriate ether dissolution mixture, after all dissolving on Rotary Evaporators 30 DEG C be evaporated film forming, then take product 3.5ml prepared by step (1), product 2.5ml prepared by step (2) and appropriate pH value are the PBS of 6.8, Tween 80 and sorbester p17 is added after stirring, in ice bath, ultrasonic emulsification 40min obtains suspension, carry out lyophilization by suspension adding after inulin stirs, obtain lipidosome freeze-dried powder standby；
(4) vaseline, Polyethylene Glycol ceteareth, hexadecanol, triethanolamine are mixed and heated to 70 DEG C, add glycerol, Semen Fructus Hippophae oil and water homogenisation stirring 30min, it is cooled to when 30 DEG C add remaining surplus materials stir, product prepared by step (3) is added after being cooled to room temperature, quality inspection after stirring, discharging, packs.
Its performance is detected by the cosmetics prepared according to embodiment, and result is as follows:
Thermostability (40 ± 1 DEG C, 24h): without oil-water separation phenomenon after recovery room temperature；Tolerance to cold (-5-10 DEG C, 24h): no significant difference front with test after recovering room temperature；Lead content (mg/Kg): 0.1；Mercury content (mg/Kg): 0.03；Arsenic content (mg/Kg): 0.04: total number of bacteria (CFU/g): ＜ 10；Yeast and mold sum (CFU/g): ＜ 10；Excrement colibacillus group: do not detect；Bacillus pyocyaneus: do not detect；Golden yellow Fructus Vitis viniferae bacillus: do not detect.

Claims (2)

  1. null1. the facial cream of a whitening anti-aging，It is characterized in that，It is made up of the raw material of following weight portion: Milk Thistle 20-25、Herba Dendrobii flower 33-37、Tilia europaea 10-13、Cranberry 16-20、Discarded hair 40-50、Conch meal 13-15、Lyophilizing apple powder 15-18、Allantoin 0.5-0.7、Tween 80 0.15-0.2、Sorbester p17 0.1-0.15、Glycine betaine 0.6-1、Soybean lecithin 6.4-8、18-amine. 1.6-2、Cholesterol 2-3、Vaseline 3-4、Anhydrous lanolin 3-4、Hexadecanol 3-4、Glyceryl monostearate 4-5、Inulin 1-2、Triethanolamine 3-4、Glycerol 6-8、Semen Fructus Hippophae oil 2-3、Polyethylene Glycol-20-ceteareth 2-3、Polyoxyethylene hydrogenated Oleum Ricini 3-4、Vitamin e1-1.5、Phenoxyethanol 0.3-0.4、Methyl parahydroxybenzoate 0.2-0.4、Water 50-60.
  2. The facial cream of a kind of whitening anti-aging, it is characterised in that be made up of step in detail below:
    (1) by after Milk Thistle, Herba Dendrobii flower, Tilia europaea and cranberry co-grinding, heating extraction 1.5-2h in 75% ethanol solution, centrifugation is carried out after being cooled to room temperature, centrifugal speed is 4000-5000rpm, and centrifugation time is 10-20min, then takes its supernatant and carries out fine straining, filtrate after fine straining is concentrated to give extractum, again extractum propylene glycol is dissolved, filter, obtain the extracting solution that content is 10mg/ml standby；
    (2) by discarded hair, conch meal cleans after drying and the mixing of lyophilizing apple powder adds zymocyte and ferments, fermentation temperature is 36-45 DEG C, time is 12-15h, gained fermentation liquid is carried out sterilizing again and is centrifuged, centrifugal rotational speed is 8000-12000r/min, centrifugation time is 10-20min, then collects supernatant standby；
    (3) soybean lecithin, 18-amine. and cholesterol are mixed, with appropriate ether dissolution mixture, after all dissolving on Rotary Evaporators 30-35 DEG C be evaporated film forming, then take product 3.5-5ml prepared by step (1), product 2.5-4ml prepared by step (2) and appropriate pH value are the PBS of 6.8, Tween 80 and sorbester p17 is added after stirring, in ice bath, ultrasonic emulsification 40-50min obtains suspension, carry out lyophilization by suspension adding after inulin stirs, obtain lipidosome freeze-dried powder standby；
    (4) vaseline, Polyethylene Glycol-20-ceteareth, hexadecanol, triethanolamine are mixed and heated to 70-75 DEG C, add glycerol, Semen Fructus Hippophae oil and water homogenisation stirring 30-35min, it is cooled to when 30-40 DEG C add remaining surplus materials stir, product prepared by step (3) is added after being cooled to room temperature, quality inspection after stirring, discharging, packs.
CN201610335992.2A 2016-05-20 2016-05-20 Whitening anti-aging facial cream Pending CN105902468A (en)

Priority Applications (1)

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CN201610335992.2A CN105902468A (en) 2016-05-20 2016-05-20 Whitening anti-aging facial cream

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107519121A (en) * 2017-09-12 2017-12-29 陈德兴 De-etiolation anti-aging face cream and preparation method thereof
CN113425663A (en) * 2021-08-18 2021-09-24 皖西学院 Preparation method of dendrobium flower soybean skin-beautifying mask

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103494719A (en) * 2013-10-12 2014-01-08 湖南金浩茶油股份有限公司 Anti-aging cream and preparation method thereof
CN104257598A (en) * 2014-09-18 2015-01-07 北京工商大学 Chinese wolfberry fermented raw stock cosmetic and preparation method thereof
CN104546989A (en) * 2014-12-15 2015-04-29 宁波杰顺生物科技有限公司 Method for preparing cranberry extract and capsules thereof
CN105147591A (en) * 2015-10-19 2015-12-16 广州科玛生物科技有限公司 Anti-wrinkle face cream and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103494719A (en) * 2013-10-12 2014-01-08 湖南金浩茶油股份有限公司 Anti-aging cream and preparation method thereof
CN104257598A (en) * 2014-09-18 2015-01-07 北京工商大学 Chinese wolfberry fermented raw stock cosmetic and preparation method thereof
CN104546989A (en) * 2014-12-15 2015-04-29 宁波杰顺生物科技有限公司 Method for preparing cranberry extract and capsules thereof
CN105147591A (en) * 2015-10-19 2015-12-16 广州科玛生物科技有限公司 Anti-wrinkle face cream and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107519121A (en) * 2017-09-12 2017-12-29 陈德兴 De-etiolation anti-aging face cream and preparation method thereof
CN113425663A (en) * 2021-08-18 2021-09-24 皖西学院 Preparation method of dendrobium flower soybean skin-beautifying mask

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Application publication date: 20160831