CN105878447A - Pharmaceutical composition for clinical children wound care and preparation method thereof - Google Patents

Pharmaceutical composition for clinical children wound care and preparation method thereof Download PDF

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Publication number
CN105878447A
CN105878447A CN201610306982.6A CN201610306982A CN105878447A CN 105878447 A CN105878447 A CN 105878447A CN 201610306982 A CN201610306982 A CN 201610306982A CN 105878447 A CN105878447 A CN 105878447A
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herba
weight
pharmaceutical composition
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刘静
马彦梅
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Yantai Minwang Electromechanical Technology Co Ltd
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Yantai Minwang Electromechanical Technology Co Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention discloses a pharmaceutical composition for clinical children wound care and a preparation method thereof. The pharmaceutical composition for clinical children wound care consists of oral pharmaceutical composition and an externally-applied pharmaceutical composition, wherein the oral pharmaceutical composition is prepared from the following raw herbal materials: bunge corydalis herb, leaves of sarmentose pepper, radix notoginseng, lucid ganoderma, capitate knotweed herb, Indian bread hostwood, rhizoma chuanxiong , fructus forsythiae and Korean raspberry root; the externally-applied pharmaceutical composition is prepared from the following raw materials: dracoceph-alum rupestre, common evolvulus herb, thymeleaf speedwell herb, embelia laeta, herba saussureae involucratae, loosestrife, nakedflower beautyberry branchlet and leaf, metaplexis japonica makino, Mountain Ren leaves, parauellia delavayana, ranunculus sceleratus, Japanese raspberry and hyperici herba. The pharmaceutical composition has the beneficial effects of sterilizing and diminishing inflammation, promoting wound healing and fading scars, and also having less irritation and an analgesia effect; the pharmaceutical composition has the advantages of rapidness in effect taking, high efficiency, definite therapeutic effect, short treatment course, no toxic and side effect, low price and the like.

Description

A kind of pharmaceutical composition of clinical infant wound care and preparation method thereof
Technical field
The present invention relates to technical field of medicine, particularly to the pharmaceutical composition of a kind of clinical infant wound care And preparation method thereof.
Background technology
In life, children's likes playing, and does not has again experience, easily imprudence scratch, abrade or scratch unavoidable, for These wounds Related Nursing to be carried out, therefore no person may cause wound infection, and then affect wound healing.It is presently used for wound After the conventional method of mouth nursing is for using normal saline or warm water to clean a wound, then use povidone iodine or medical alcohol wiping wound. Or for smaller wound directly against adhesive bandage.Povidone iodine, medical alcohol zest big, clinical debridement effect is undesirable；And create Breathability can be pasted bad, be unfavorable for the quickly-healing of wound.The most above-mentioned wound care mode is generally used for little wound, place Manage fairly simple.For large-area wound, infection rate is high, and easily stays scar, accordingly, it would be desirable to more professional nursing care mode.
Summary of the invention
The technical problem to be solved is, it is provided that the pharmaceutical composition of a kind of clinical infant wound care and Its preparation method, the present invention has a bactericidal antiphlogistic, promotes wound healing and effect of desalination cicatrix, has that zest is little and analgesia concurrently Effect, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.
In order to solve above-mentioned technical problem, the present invention provides the pharmaceutical composition of a kind of clinical infant wound care, its In, it being made up of oral medicament composition and externally-applied medicinal composition, described oral medicament composition is former by following parts by weight Material medical material is made: Herba Corydalis Bungeanae 12-24 weight portion, phyllodium 14-28 weight portion, Radix Notoginseng 11-21 weight portion, Ganoderma 9-18 weight Part, Herba Polygoni Capitati 12-32 weight portion, Lignum Poria 15-25 weight portion, Rhizoma Chuanxiong 13-33 weight portion, Fructus Forsythiae 2-4 weight portion and Radix rubi coreani 15-35 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris's 10-20 weight portion, Herba Evolvuli Alsinoides 14-28 weight portion, Herba Veronicae Serpyllifoliae 16-32 weight portion, tart fruit rattan 15-35 weight portion, Herba Saussureae Involueratae 14-26 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 16-22 Weight portion, Folium et Ramulus Callicarpae nudiflorae 15-26 weight portion, trailing plants 15-35 weight portion, mountain leaf 11-24 weight portion, Herb Pararuelliae delavayanae 13-31 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3-5 weight portion, ull up field 9-18 weight portion and Herba Hyperici 10-25 weight portion.
Described oral medicament composition is made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 14-22 weight portion, vacation Leaf 15-25 weight portion, Radix Notoginseng 14-20 weight portion, Ganoderma 10-16 weight portion, Herba Polygoni Capitati 14-30 weight portion, Lignum Poria 16-24 weight Amount part, Rhizoma Chuanxiong 15-30 weight portion, Fructus Forsythiae 2-3 weight portion and Radix rubi coreani 16-34 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris's 12-20 weight portion, Herba Evolvuli Alsinoides 15-25 weight portion, Herba Veronicae Serpyllifoliae 18-30 weight portion, tart fruit rattan 15-35 weight portion, Herba Saussureae Involueratae 15-24 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 18-20 Weight portion, Folium et Ramulus Callicarpae nudiflorae 15-24 weight portion, trailing plants 15-34 weight portion, mountain leaf 12-22 weight portion, Herb Pararuelliae delavayanae 13-30 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3-4 weight portion, ull up field 10-16 weight portion and Herba Hyperici 10-24 weight portion.
Described oral medicament composition is made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 20 weight portion, phyllodium 18 weight portions, Radix Notoginseng 16 weight portion, Ganoderma 15 weight portion, Herba Polygoni Capitati 22 weight portion, Lignum Poria 18 weight portion, Rhizoma Chuanxiong 30 weight Part, Fructus Forsythiae 2 weight portion and Radix rubi coreani 33 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris 16 weight portion, Herba Evolvuli Alsinoides 24 weight Amount part, Herba Veronicae Serpyllifoliae 20 weight portion, tart fruit rattan 16 weight portion, Herba Saussureae Involueratae 22 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 18 weight portion, Folium et Ramulus Callicarpae nudiflorae 16 weight Part, trailing plants 34 weight portion, mountain leaf 21 weight portion, Herb Pararuelliae delavayanae 25 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3 weight portion, ull up field 15 weight portion and Herba Hyperici 22 weight portion.
Described oral medicament composition is made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 15 weight portion, phyllodium 16 weight portions, Radix Notoginseng 20 weight portion, Ganoderma 11 weight portion, Herba Polygoni Capitati 25 weight portion, Lignum Poria 22 weight portion, Rhizoma Chuanxiong 30 weight Part, Fructus Forsythiae 2 weight portion and Radix rubi coreani 23 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris 14 weight portion, Herba Evolvuli Alsinoides 21 weight Amount part, Herba Veronicae Serpyllifoliae 25 weight portion, tart fruit rattan 32 weight portion, Herba Saussureae Involueratae 22 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 19 weight portion, Folium et Ramulus Callicarpae nudiflorae 23 weight Part, trailing plants 33 weight portion, mountain leaf 15 weight portion, Herb Pararuelliae delavayanae 17 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3 weight portion, ull up field 12 weight portion and Herba Hyperici 20 weight portion.
When the dosage form of described oral medicament composition is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described pharmaceutical composition raw medicinal material, adds relative to mixture quality 3～5 times Determining alcohol is the ethanol of 85%～95%, is heated to reflux 4～6 hours, extracts, and filters and obtains the first extracting solution；Filter the medicine obtained Slag adds the ethanol that determining alcohol is 90%～95% relative to described medicinal residues quality 2～4 times, is heated to reflux 1～3 hour, carries Take, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, Obtain and get dry extract；
Second step, is placed in super micron mill pulverizing 1～3 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 400 Mesh～the micropowders of 500 mesh；
3rd step, the micropowders that second step is obtained, add relative to its quality 0.1～the microcrystalline Cellulose of 0.2 times, 0.15 ～0.3 times of lactose, starch of 0.2～0.3 times, sieve, mix homogeneously, pelletize, be dried, add relative to micropowders quality 0.025～0.04 times of magnesium stearate, granulate, tabletting, make.
When the dosage form of described externally-applied medicinal composition is liniment, its preparation method comprises the following steps:
The first step, is first ground into coarse powder by described raw medicinal material, further pulverizes, and crosses 100 mesh sieves, enables by 100 mesh sieves Fine powder amount be at least up to 40%, collect and obtain fine powder a by the fine powder of 100 mesh sieves；
Second step, it is impossible to put into multi-function extractor by the coarse powder of 100 mesh sieves and extract twice, add weight portion 8-10 for the first time Times amount soak by water 1-3 hour, second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to obtain filter Liquid；The heating of gained filtrate is concentrated into pasty state, and after putting into the drying of 80 DEG C of baking oven, room temperature cools down, and grinds to form fine powder b；
3rd step, calls in glycerol after being mixed with fine powder b by fine powder a and makes liniment.
When the dosage form of described externally-applied medicinal composition is medicinal liquid, its preparation method comprises the following steps: by described external In pharmaceutical composition, each raw medicinal material is respectively fed in pulverizer be ground into powder in proportion, is then fed in blender stirring mixed Close, it is thus achieved that mixture, mixture is sent into and decocts 2-3 hour relative to heating in the water of its quality 3-5 times, filter subsequently, obtain The first extracting solution, filtering residue is fed again into relative in the water of its quality 2-4 times, heating and refluxing extraction 1-2 hour, subsequently mistake Filter, it is thus achieved that the second extracting solution, merges the first extracting solution and the second extracting solution, it is thus achieved that traditional Chinese medicine composition extract liquid, in temperature is 60-70 DEG C, vacuum is to carry out being concentrated in vacuo to portion of water under conditions of 0.08-0.1mpa to be evaporated off, it is thus achieved that crude drug concentration Medicinal liquid for 1g/ml-2g/ml.
The invention has the beneficial effects as follows: the present invention has bactericidal antiphlogistic, promote wound healing and effect of desalination cicatrix, hold concurrently Irritant little and analgesic acts on, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, valency The advantages such as lattice are low.
Detailed description of the invention
The present invention provides pharmaceutical composition of a kind of clinical infant wound care and preparation method thereof, wherein, by taking orally Pharmaceutical composition and externally-applied medicinal composition form, and described oral medicament composition is made up of following various raw medicinal materials: bitter ground Fourth, phyllodium, Radix Notoginseng, Ganoderma, Herba Polygoni Capitati, Lignum Poria, Rhizoma Chuanxiong, Fructus Forsythiae and Radix rubi coreani；Described externally-applied medicinal composition is by following Various raw medicinal materials are made: Herba Dracocephali Rupestris's Herba Evolvuli Alsinoides, Herba Veronicae Serpyllifoliae, tart fruit rattan, Herba Saussureae Involueratae, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Folium et Ramulus Callicarpae nudiflorae, trailing plants, mountain leaf, Herb Pararuelliae delavayanae, Herba Ranunculi Scelerati (Radix Anemones rupicolae), ull up field and Herba Hyperici.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Herba Hyperici: another name: Hunan Fructus Forsythiae, hypericum ascyron, Cor Bovis seu Bubali dish, great Ye Cor Bovis seu Bubali dish, Cor Gigeriae Galli dish, big goldspink, spun gold butterfly, to warp Grass, Rabdosia stracheyi(Benth.ex Hook.f.)Hara[Plectranthus stracheyi Benth.ex Hook.f..Source: for Hypericaceae hypericum Herba Hyperici Hypericum ascyron L., with all herbal medicine.Summer Autumn gathers herb, and clean chopping is dried.Nature and flavor: bitter, cold.Cure mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing.For spitting blood, spitting of blood, epistaxis, Metrorrhagia, jaundice, hepatitis；Wound hemorrhage, burn and scald, eczema, impetigo are controlled in external.
Trailing plants: another name: white ring rattan, Herba seu Radix Metaplexis hemsleyanae, Pericarpium Metaplexis, grandmother's sewing kit, Metaplexis japonica (Thunb.)Makino.Source: Luo Keluo genus is planted Thing trailing plants Metaplexis japonica (Thunb.) Makino, is used as medicine with tuber, herb and shell.Fruit picking in autumn, summer Adopt tuber and herb, dry.Nature and flavor: root: sweet, temperature.Shell: pungent, temperature.Herb: sweet, micro-pungent, temperature.Cure mainly: root: QI invigorating benefit essence. For having a delicate constitution, sexual impotence, leucorrhea, hypogalactia, infantile malnutrition；Furuncle, agkistrodon acutus bite are controlled in external.Shell: qi-restoratives is supporing yang, Relieving cough and resolving phlegm.For having a delicate constitution, phlegm dyspnea is coughed, pertussis, sexual impotence, seminal emission；Wound hemorrhage (with kind of a hair patch affected part) is controlled in external. Herb: strong, promoting flow of QI and blood, subduing swelling and detoxicating.For emission due to deficiency of the kidney, hypogalactia；Furuncle toxic swelling, worm, venom are controlled in external.
Ull up field: source: " detailed outline ".Another name: (" elegant "), She Pao, Caulis et Radix Periplocae Forrestii (" the SHENGCAO property of medicine is standby to be wanted "), March Bubble (" Chenxi county annals "), Fructus Mume disappears, red trivial prunus mume (sieb.) sieb.et zucc., Caulis Entadae, build umbrella (" Zhiwu Mingshi Tukao "), ulls up seedling bubble (" classification medical herbs Property "), tooth eagle (" Guangzhou flora "), Radix rubi coreani, Mao Yexian bridge (" Guizhou side among the people medicine collection "), Herba Rubi parvifolii, cloth field spinach grass, Broadcast field flower (" Fujian traditional herbal medicine "), acute mastitis bubble, the claws of a hawk, farming Pu (" Guangxi Chinese veterinarian's medicine is planted "), Herba Rubi parvifolii (" river Su Zhi medicine will "), XISHE water hole, little revive after death (" Nanning City's medicine will "), May thorn, dragon-boat, Flos Carthami bladder (" Jiangxi grass among the people Medicine "), the bubble that transplants seedlings (" Chongqing medical herbs "), She Pao fruit (" CHINESE JOURNAL OF INTERNAL MEDICINE " 8(4): 359,1960
Source: for the herb of rosaceous plant Rubus Parvifolius L..7～gather August, extract herb, be bundled into wisp, dry.Nature and flavor: sweet acid, Flat.1. " the SHENGCAO property of medicine is standby to be wanted ": " puckery acid." 2. " book on Chinese herbal medicine asks former ": " is sour and astringent, flat." 3. " south of the Five Ridges gather medicinal herbs record ": " bitter in the mouth, micro- Cold." 4. " Nanning City's medicine will ": " is sweet, flat, nontoxic." cure mainly: dissipating blood stasis, pain relieving, removing toxic substances, parasite killing.Control haematemesis, traumatic injury knife injury, produce The stagnant stomachache of the rear stasis of blood, dysentery, hemorrhoid, scabies, scrofula.1. " the SHENGCAO property of medicine is standby to be wanted ": " except scabies, parasite killing, go out tinea versicolor, wash infantile malnutrition hemorrhoid；Leaching Scrofula controlled by wine；Ten steam nine solarizations controls haematemesis, only toothache." 2. " book on Chinese herbal medicine asks former ": ": only knife injury blood." 3. " Nanning City's medicine will ": " Dissipating blood stasis, pain relieving, reduce phlegm.Control traumatic injury, cough, puerperal the stasis of blood pain, bloody dysentery, hot eye."
Herba Veronicae Serpyllifoliae: source: " Shaanxi medical herbs ".Another name: purslane speedwell Herba, foster leather and fur (" Shaanxi Chinese herbal medicine ").Source: for Radix Scrophulariae kind plant Little Herba veronicae fruit has the herb of insect gall.6～picking fruit has July the herb of insect gall, dry after steaming or using fresh herb.Nature and flavor: 1. " Shaanxi Chinese herbal medicine ": " sweet in the mouth is pained, and property is put down." 2. " Shaanxi medical herbs ": " sour-puckery flavor, property is put down." cure mainly: promoting blood circulation and hemostasis, heat clearing away Removing toxic substances.Control traumatic injury, menoxenia, wound hemorrhage, aphtha, burn.1. " Shaanxi Chinese herbal medicine ": " promoting blood circulation to remove blood stasis, hemostasis, Removing toxic substances.Control traumatic injury, inside have blood stasis, traumatic hemorrhage, menoxenia, venom." 2. " Shaanxi medical herbs ": " restrains, hemostasis, disappears Scorching.Control burn, aphtha, obstinate pyogenic sore of the skin."
Herba Saussureae Involueratae: source: Compositae Genus Saussurea plant Saussurea laniceps Saussurea laniceps Hand.-Mazz. and hair Head Herba Saussureae Involueratae S. eriocephala Franch, is used as medicine with whole herb with root.Summer gathers, and Herb pulls up, and trembles clean silt, dries. Nature and flavor: hardship sweet, micro-, temperature.Cure mainly: kidney invigorating and YANG supporting, regulating menstruation, hemostasis.For snow blindness, toothache, rheumatic arthritis, sexual impotence, menstruation is not Adjust, metrorrhagia, leucorrhea；Wound hemorrhage is controlled in external.
Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis): another name: red heron scapular, pass by one's way red, capon tail, Coniogramme japonica (Thunb.) Diels, Arisaema balansae Engl. grass, red stalk grass careless, barefoot, wolf tail Flower, wolf tail Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).Source: Primulaceae Lysimachia tabasheer dish Lysimachia clethroides Duby, with root and All herbal medicine.Xia Qiu gathers, and cleans, chops up, using fresh herb or dry.Nature and flavor: pungent, micro-puckery are flat.Curing mainly: promoting blood flow to regulate menstruation, removing toxic substances disappears Swollen.For menoxenia, leucorrhea, infantile malnutrition, rheumatic arthritis, traumatic injury, mastitis, venom.
Mountain leaf: source: " the SHENGCAO property of medicine is standby to be wanted ".Source: for the myrtaceous leaf of myrtle.The whole year can adopt.Property Taste: sweet is flat.1. " the SHENGCAO property of medicine is standby to be wanted ": " sweet in the mouth, property is put down." 2. " book on Chinese herbal medicine asks former ": " is puckery, flat." cure mainly: control headache, dysentery, Infantile malnutrition, traumatic hemorrhage, skin ulcer scabies.1. " the SHENGCAO property of medicine is standby to be wanted ": " pain relieving, heat radiation poison, hemostasis, dial pus, granulation promoting." 2. " book on Chinese herbal medicine is asked Former ": " hemostasis, dysentery relieving, granulation promoting.Controlling infantile malnutrition, disappear skin ulcer, washes infantile malnutrition hemorrhoid, pyretic toxicity, hysteria scabies, rotten foot, manages snakebite." 3. " Guangxi Chinese medicine Will ": " harness the river and rush down, red Hakuri；Traumatic hemorrhage, acute mastitis are controlled in external."
Herba Evolvuli Alsinoides: source: " Fujian traditional herbal medicine ".Another name: the peppery flower of hair, filamentary silver grass (" Guangzhou flora "), starvation grass, fawn Rank, Herba Pyrolae, small capital Pemisetum flaccidum Griseb, heath bell, dysentery grass (" Fujian traditional herbal medicine "), Flos Lonicerae grass (" Nanning City's medicine will "), hair General's (" Quanzhou book on Chinese herbal medicine "), Herba Stenosolenii saxatilis, Bai Maolian, white hair are by (" Guangdong Chinese medicine "), pigeon grass (Guangzhou army " conventional Chinese herbal medicine Handbook ").Source: for the herb of convolvulaceous plant Herba Evolvuli Alsinoides.Nature and flavor: toil are cool.1. " Fujian traditional herbal medicine ": " sweet micro-hardship, Flat." 2. " Nanning City's medicine will ": " is pungent, cool." 3. " Guangdong Chinese medicine ": " is lightly seasoned, slightly cool in nature." return through: " Quanzhou book on Chinese herbal medicine ": " enters Liver,spleen,kidney three warp." cure mainly: heat clearing away, dampness removing.Harnessing the Yellow River subcutaneous ulcer, dysentery, stranguria with turbid discharge, leukorrhagia, furuncle swells, scabies.1. " Fujian grass among the people Medicine ": " clearing away heat-fire, arresting seminal emission tonifying YIN." 2. " Nanning City's medicine will: " external hemostasia and detumescence, removing heat from the liver, nebula removing." 3. " in Guangdong Medicine ": " clearing away damp-heat.Control dysentery, damp and hot belly pain."
Herba Ranunculi Scelerati (Radix Anemones rupicolae): another name: without hair smallage, duck palm, water violet, water cucumber perfume, hammer of beating a gong, delicate fragrance grass.Source: for Ranunculaceae hair Gelsemium platymiscium Herba Ranunculi Scelerati (Radix Anemones rupicolae) Ranunculus sceleratus L., with all herbal medicine.Summer gathers, and cleans and dries or using fresh herb.Property Taste: bitter, pungent is flat.Poisonous.Cure mainly: detumescence, eliminating stagnation of drawing out pus by applying a plaster to the affected part, preventing the attack (or recurrence) of malaria.For tuberculous lymphadenitis, malaria, carbuncle, venom, chronic Ulcer of the lower limb.[extracts] " whole nation Chinese herbal medicine compilation ".
Herb Pararuelliae delavayanae: source: " choosing of Yunnan Chinese herbal medicine ".Another name: ground hide glue, Folium Ainslaea Triflorae, maggot medicine (" Yunnan Chinese herbal medicine ").Come Source: for the herb of acanthaceous plant happiness oak little bud Herba Rostellulariae.Summer, autumn gather, and chopping is dried.Nature and flavor: " Yunnan Chinese herbal medicine ": " sweet Light, flat." cure mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Control pneumonia, tonsillitis, parotitis, scrofula, abscess sore, fracture, wound Infect.1. " Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control fracture, tuberculous lymphadenitis, parotitis, traumatic hemorrhage."② " choosing of Yunnan Chinese herbal medicine ": " antiinflammatory is drawn out pus by applying a plaster to the affected part, granulation promoting, dissipating blood stasis tissue regeneration promoting, parasite killing.Control acute suppurative tonsillitis, pneumonia, sore pus Swollen, the raw maggot of wound infection." 3. " catalogue planted by Guizhou medicine ": " controls impairment caused by overstrain, delivers."
Tart fruit rattan: another name: Embelia laeta, Fructus embeliae laetae, mountain hydrochloric acid chicken, vinegar rattan, enter Pheretima, embelin.Source: Myrsinacea pillar-box Sub-platymiscium tart fruit rattan Embelia laeta (L.) Mez (E. obovata Hemsl.), with root, leaf and fruit medicine.Root, Leaf can be adopted the whole year, and root is cleaned section and dried, and leaf dries or using fresh herb；Fruit picking in summer, cooks and dries.Nature and flavor: root, leaf: acid are flat.Really: Sweet, sour, flat.Cure mainly: root, leaf: stasis-dispelling and pain-killing, antiinflammatory, antidiarrheal.Root is used for dysentery, enteritis, dyspepsia, laryngopharynx swelling and pain, traumatic injury Damage；Traumatic injury, skin pruritus are controlled in leaf external.Really: strong, enrich blood.For amenorrhea, anemia, achlorhydria.
Folium et Ramulus Callicarpae nudiflorae: source: " south of the Five Ridges gather medicinal herbs record ".Another name: the reddest (" Nanning City's medicine will "), meal soup leaf, sub-stockaded village are all, big Cushat rice (" register planted by Guangxi medicine ").Source: for the leaf with twig of Verbenaceae Callicarpa nudiflora.Distribution China south Portion.Nature and flavor: 1. " Nanning City's medicine will ": " pungent puckery." 2. " Guangdong Chinese medicine " II: " micro-hardship, property is put down." cure mainly: hemostasis, antiinflammatory, dispel The stasis of blood, pain relieving.That controls that pneumorrhagia type leptospirosis, pulmonary tuberculosis, lung abscess, lobar pneumonia etc. cause is hemorrhage, Peptic Ulcers etc. The upper gastrointestinal hemorrhage caused, thrombocytopenic purpura, hematuria, wound hemorrhage, influenza, burn, suppurative skin ulcer, son Cervical erosion, traumatic injury, rheumatalgia.1. " south of the Five Ridges gather medicinal herbs record ": " leaf: decoct washing traumatic injury wound, can eliminating blood stasis to promote regeneration of blood.Such as swelling due to wind, Leaf is decocted washing, takes its stalk and lean pork decoction, can wind dispelling detumescence." 2. " Nanning City's medicine will ": " stops blooding, pain relieving.Control traumatic injury Damage, gunshot wound." 3. " register planted by Guangxi medicine ": " dispelling the wind and dampness pathogens."
Herba Dracocephali Rupestris: source: " plateau Chinese herbal treatment handbook ".Another name: Ha Dun-Bi Yanggu (illiteracy name), that crow Huang is (Tibetan name). Source: for the herb of labiate Herba Dracocephali Rupestris.7～adopt herb August, clean, dry.Nature and flavor: Gan Xin is cool.1. " plateau medium-height grass Medicine treatment handbook ": " pungent, cool." 2. " Inner Mongol Chinese herbal medicine ": " sweetness and bitterness, flat." return through: " plateau Chinese herbal treatment handbook ": " enter lung, Stomach, spleen three warp." cure mainly: heat clearing and inflammation relieving, cooling blood for hemostasis.Control affection due to external wind and heat, cold and heat of having a headache, laryngalgia, cough, icterohepatitis, tell Blood, epistaxis, dysentery.1. " plateau Chinese herbal treatment handbook ": " antipyretic antiinflammatory.Control headache due to pathogenic wind-heat, laryngalgia cough, diseases caused by exogenous pathogenic factor folder food, breast Gastral cavity distension." 2. " Inner Mongol Chinese herbal medicine ": " heat clearing and damp drying, cool liver is stopped blooding.Control headache, jaundice, spit blood, epistaxis, pharyngalgia, dysentery."
Radix rubi coreani: source: " Chongqing medical herbs ".Another name: crow bubble Radix rubi rosafolii, two grass, oolong hair (" Chongqing medical herbs "), Caulis Entadae (" Shaanxi Chinese herbal medicine ").Source: for the root of rosaceous plant rubus coreanus.The whole year can adopt, and is dug preferably with 9～October.Nature and flavor: acid Salty, flat.1. " Chongqing medical herbs ": " sour in the mouth is salty, and property is put down, nontoxic." 2. " Shaanxi Chinese herbal medicine ": " bitter and puckery flavor, cool in nature." cure mainly: invigorate blood circulation, Hemostasis.Control over-strained hemoptysis, epistaxis, menoxenia, traumatic injury.1. " Chongqing medical herbs ": " promoting flow of QI and blood, raw kidney water.Control impairment caused by overstrain to tell Blood, menoxenia, sub-scrofula of itching." 2. " Shaanxi Chinese herbal medicine ": " regulating menstruation and activating blood, hemostasis and pain-relieving.Control traumatic injury, fracture, infertile Disease, menoxenia, epistaxis."
Lignum Poria: another name: yellow pine joint, Lignum Pini Nodi, Fu Shenxin, Poria cum Radix Pini's heart wood, poria wood.Source: come from Compendium of Material Medica.Source: Medical material Ji Yuan: for the Radix Pini massonianae in the middle of On Polyporaceae poria cocos sclerotium.Latin plant animal mineral name: Poria cocos (Schw.) Wolf. [Pavhyma cocos Fr.] gathers and stores: adopt Poria, the person that has Radix Pini massonianae in first selecting, and knock-off Siberian cocklebur block (is made Poria is used), pick fine.Nature and flavor: sweet；Property flat.Gui Jing: liver；Heart channel.Cure mainly: suppressing the hyperactive liver is calmed the nerves.Main palpitation with fear is forgetful；Apoplexy language Not smoothgoing；Tinea pedis is had a cramp.
Ganoderma: another name: Ganoderma lucidum seu Japonicum, Ganoderma, Ganoderma Lucidum.Source: this product is On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma Lucidum(Leyss.ex Fr.) the dry son of Karst. or Ganoderma Ganoderma sinense Zhao, Xu et Zhang is real Body.The whole year gathers, and removes impurity, wipes out the lower end stem with rotten wood, silt or culture matrix, dry in the shade or 40～50 DEG C of bakings Dry.Nature and flavor: sweet are flat.Gui Jing: GUIXIN, lung, liver, kidney channel.Cure mainly: invigorating QI and tranquilization, relieving cough and asthma.For dizziness sleeplessness, cardiopalmus gas Short, asthenia cough with asthma.
Rhizoma Chuanxiong: another name: rhizome of chuanxiong, Rhizoma Chuanxiong.Source: this product is samphire Rhizoma Chuanxiong Ligusticum Chuanxiong Hort.(or Ligusticum wallichii Franch.) dry rhizome.Summer shows when the joint dish on stem Prominent, and excavate during purplish, remove silt, after solarization, a heatable brick bed is done, then removes fibrous root.Nature and flavor: pungent, temperature.Gui Jing: return liver, gallbladder, the heart Bao Jing.Cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen suffers from abdominal pain, breast side of body twinge, tumbling and swelling, Headache, rheumatic arthralgia.
Phyllodium: source: " the SHENGCAO property of medicine is standby to be wanted ".Source: for the blade that Piperaceae plant is false.Nature and flavor: 1. " SHENGCAO medicine Property standby want ": " bitter in the mouth, warm in nature, nontoxic." 2. " book on Chinese herbal medicine asks former ": " toil, temperature." cure mainly: warming middle-JIAO, circulation of qi promoting, dispel the wind, detumescence.Control stomach Cold pain, flatulence of suffering from abdominal pain, lumbago due to pathogenic wind-dampness, puerperal deficiency of vital energy swelling of the feet, treating swelling and pain by traumatic injury, traumatic hemorrhage.1. " the SHENGCAO property of medicine is standby to be wanted ": " dispel the wind, Puerperal, deficiency of vital energy swelling of the feet, boiled bullhead food or pot washing." 2. " Luchuan book on Chinese herbal medicine ": " promoting the circulation of QI for relieving swelling, pain relieving, wind dispelling.Control beriberi edema, Stomachache flatulence." 3. " Nanning City's medicine will ": " dispels the wind, warming middle-JIAO, controls cold syndrome of the stomach pain, washes rotten foot."
Fructus Forsythiae: another name: Fructus Forsythiae, Hemerocallis citrina Baroni bar, yellow chain barriness, Huang Qidan, green grass or young crops stick up, fall to sticking up.Source: this product is Oleaceae plants Fructus Forsythiae The dry fruit of Forsythia suspensa (Thunb.) Vahl.Gather during fruit just ripe still band green in autumn, remove miscellaneous Matter, cooks, and dries, and practises and claims " green grass or young crops sticks up "；Gather when fruit is well-done, dry, remove impurity, practise and claim " always sticking up ".Nature and flavor: bitter, micro- Cold.Gui Jing: return lung, the heart, small intestine meridian.Cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, wind heat sense Emit, epidemic febrile disease from the beginning of, warm is joined the army, high hot excessive thirst, and coma sends out speckle, pyretic stranguria urine retention.
Radix Notoginseng: source: this product is the dry of panax araliaceae plant Panax notoginseng (Burk.) F. H. Chen Dry.Autumn excavates before the flowers are in blossom, cleans, separately main root, supporting root and stem foot, is dried.Supporting root is practised and is claimed " rib ", and stem foot is practised and claimed " to cut Mouthful ".Nature and flavor: hardship sweet, micro-, temperature.Gui Jing: return liver, stomach warp.Cure mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting blood, spit blood, epistaxis, Having blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Herba Polygoni Capitati: source: " Guangxi Chinese medicinal herbal ".Another name: Polygonum capitatum Buch (" Guangxi Chinese medicinal herbal "), Herba Polygoni Capitati, Herba Parthenocissi Himalayanae are (" extensively Western plant list "), Herba Polygoni Capitati (" Yunnan Chinese herbal medicine "), Man Dihong, Herba Polygoni Capitati, fire slip grass (" mountain of papers Chinese herbal medicine "), Flos Carthami ground Fourth, silk ball grass, Herba Thalictri elati, little copper weed, small red grass (" choosing of Yunnan Chinese herbal medicine ").Source: for the herb of polygonaceae plant Herba Polygoni Capitati.Entirely Year can adopt, and dries or using fresh herb.Nature and flavor: toil, temperature.1. " Guangxi Chinese medicinal herbal ": " acrid in the mouth is micro-puckery, warm in nature." 2. " Guangxi medium-height grass Medicine ": " bitter in the mouth is pungent, and property is put down, nontoxic." 3. " Yunnan Chinese herbal medicine ": " acid, cool." cure mainly: removing toxic substances, dissipating blood stasis, inducing diuresis for treating stranguria syndrome.Control dysentery, Pyelitis, cystitis, lithangiuria, rheumatalgia, traumatic injury, skin infection eczema.1. " Guangxi Chinese medicinal herbal ": " wind-damp dispelling, dissipating blood stasis is only Bitterly.Dispelling the wind and dampness pathogens, traumatic injury." 2. " Guangxi Chinese herbal medicine ": " detoxicating, relieving inflammation.Control dysentery, skin ulcer, innominate toxic swelling." 3. " in Yunnan Medical herbs ": " clearing away heat and promoting diuresis, treating stranguria."
Herba Corydalis Bungeanae: another name: Herba Violae, Herba Lactucae formosanae, chicken dish.Source: Papaveraceae Genus Corydalis Herba Corydalis Bungeanae Corydalis The herb of bungeana Turcz..Xia Qiu gathers herb, removes silt, dries standby.Nature and flavor: bitter, cold.Cure mainly: heat clearing away solution Poison, promoting blood circulation and detumescence.For influenza, upper respiratory tract infection, bronchitis, acute nephritis, jaundice, enteritis, furuncle swelling toxin, Tuberculous lymphadenitis, eye conjunctivitis, corneal ulcer.
Being made up of oral medicament composition and externally-applied medicinal composition, described oral medicament composition is by following parts by weight Raw medicinal material make: Herba Corydalis Bungeanae 12-24 weight portion, phyllodium 14-28 weight portion, Radix Notoginseng 11-21 weight portion, Ganoderma 9-18 weight Amount part, Herba Polygoni Capitati 12-32 weight portion, Lignum Poria 15-25 weight portion, Rhizoma Chuanxiong 13-33 weight portion, Fructus Forsythiae 2-4 weight portion and life of falling Root 15-35 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris's 10-20 weight portion, Herba Evolvuli Alsinoides 14-28 weight portion, Herba Veronicae Serpyllifoliae 16-32 weight portion, tart fruit rattan 15-35 weight portion, Herba Saussureae Involueratae 14-26 weight portion, Fructus Liquidambaris 15-35 Weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 16-22 weight portion, Folium et Ramulus Callicarpae nudiflorae 15-26 weight portion, trailing plants 15-35 weight portion, mountain leaf 11-24 weight portion, Herb Pararuelliae delavayanae 13-31 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3-5 weight portion, ull up field 9-18 weight portion and Herba Hyperici 10-25 weight portion.
Described oral medicament composition is made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 14-22 weight portion, vacation Leaf 15-25 weight portion, Radix Notoginseng 14-20 weight portion, Ganoderma 10-16 weight portion, Herba Polygoni Capitati 14-30 weight portion, Lignum Poria 16-24 weight Amount part, Rhizoma Chuanxiong 15-30 weight portion, Fructus Forsythiae 2-3 weight portion and Radix rubi coreani 16-34 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris's 12-20 weight portion, Herba Evolvuli Alsinoides 15-25 weight portion, Herba Veronicae Serpyllifoliae 18-30 weight portion, tart fruit rattan 15-35 weight portion, Herba Saussureae Involueratae 15-24 weight portion, Fructus Liquidambaris 16-34 Weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 18-20 weight portion, Folium et Ramulus Callicarpae nudiflorae 15-24 weight portion, trailing plants 15-34 weight portion, mountain leaf 12-22 weight portion, Herb Pararuelliae delavayanae 13-30 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3-4 weight portion, ull up field 10-16 weight portion and Herba Hyperici 10-24 weight portion.
Described oral medicament composition is made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 20 weight portion, phyllodium 18 weight portions, Radix Notoginseng 16 weight portion, Ganoderma 15 weight portion, Herba Polygoni Capitati 22 weight portion, Lignum Poria 18 weight portion, Rhizoma Chuanxiong 30 weight Part, Fructus Forsythiae 2 weight portion and Radix rubi coreani 33 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris 16 weight portion, Herba Evolvuli Alsinoides 24 weight Amount part, Herba Veronicae Serpyllifoliae 20 weight portion, tart fruit rattan 16 weight portion, Herba Saussureae Involueratae 22 weight portion, Fructus Liquidambaris 33 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 18 weight Part, Folium et Ramulus Callicarpae nudiflorae 16 weight portion, trailing plants 34 weight portion, mountain leaf 21 weight portion, Herb Pararuelliae delavayanae 25 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3 weight portion, ull up Field 15 weight portion and Herba Hyperici 22 weight portion.
Described oral medicament composition is made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 15 weight portion, phyllodium 16 weight portions, Radix Notoginseng 20 weight portion, Ganoderma 11 weight portion, Herba Polygoni Capitati 25 weight portion, Lignum Poria 22 weight portion, Rhizoma Chuanxiong 30 weight Part, Fructus Forsythiae 2 weight portion and Radix rubi coreani 23 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris 14 weight portion, Herba Evolvuli Alsinoides 21 weight Amount part, Herba Veronicae Serpyllifoliae 25 weight portion, tart fruit rattan 32 weight portion, Herba Saussureae Involueratae 22 weight portion, Fructus Liquidambaris 30 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 19 weight Part, Folium et Ramulus Callicarpae nudiflorae 23 weight portion, trailing plants 33 weight portion, mountain leaf 15 weight portion, Herb Pararuelliae delavayanae 17 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3 weight portion, ull up Field 12 weight portion and Herba Hyperici 20 weight portion.
When the dosage form of described oral medicament composition is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described pharmaceutical composition raw medicinal material, adds relative to mixture quality 3～5 times Determining alcohol is the ethanol of 85%～95%, is heated to reflux 4～6 hours, extracts, and filters and obtains the first extracting solution；Filter the medicine obtained Slag adds the ethanol that determining alcohol is 90%～95% relative to described medicinal residues quality 2～4 times, is heated to reflux 1～3 hour, carries Take, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, Obtain and get dry extract；
Second step, is placed in super micron mill pulverizing 1～3 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 400 Mesh～the micropowders of 500 mesh；
3rd step, the micropowders that second step is obtained, add relative to its quality 0.1～the microcrystalline Cellulose of 0.2 times, 0.15 ～0.3 times of lactose, starch of 0.2～0.3 times, sieve, mix homogeneously, pelletize, be dried, add relative to micropowders quality 0.025～0.04 times of magnesium stearate, granulate, tabletting, make.
When the dosage form of described externally-applied medicinal composition is liniment, its preparation method comprises the following steps:
The first step, is first ground into coarse powder by described raw medicinal material, further pulverizes, and crosses 100 mesh sieves, enables by 100 mesh sieves Fine powder amount be at least up to 40%, collect and obtain fine powder a by the fine powder of 100 mesh sieves；
Second step, it is impossible to put into multi-function extractor by the coarse powder of 100 mesh sieves and extract twice, add weight portion 8-10 for the first time Times amount soak by water 1-3 hour, second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to obtain filter Liquid；The heating of gained filtrate is concentrated into pasty state, and after putting into the drying of 80 DEG C of baking oven, room temperature cools down, and grinds to form fine powder b；
3rd step, calls in glycerol after being mixed with fine powder b by fine powder a and makes liniment.
When the dosage form of described externally-applied medicinal composition is medicinal liquid, its preparation method comprises the following steps: by described external In pharmaceutical composition, each raw medicinal material is respectively fed in pulverizer be ground into powder in proportion, is then fed in blender stirring mixed Close, it is thus achieved that mixture, mixture is sent into and decocts 2-3 hour relative to heating in the water of its quality 3-5 times, filter subsequently, obtain The first extracting solution, filtering residue is fed again into relative in the water of its quality 2-4 times, heating and refluxing extraction 1-2 hour, subsequently mistake Filter, it is thus achieved that the second extracting solution, merges the first extracting solution and the second extracting solution, it is thus achieved that traditional Chinese medicine composition extract liquid, in temperature is 60-70 DEG C, vacuum is to carry out being concentrated in vacuo to portion of water under conditions of 0.08-0.1mpa to be evaporated off, it is thus achieved that crude drug concentration Medicinal liquid for 1g/ml-2g/ml.
Embodiment 1 pharmaceutical composition 1
Pharmaceutical composition 1 of the present invention includes the liniment of tablet and the external taken orally, and wherein, the manufacturing process of tablet is: take bitter ground Fourth 200g, phyllodium 180g, Radix Notoginseng 160g, Ganoderma 150g, Herba Polygoni Capitati 220g, Lignum Poria 180g, Rhizoma Chuanxiong 300g, Fructus Forsythiae 20g and Radix rubi coreani 330g；
The first step, is mixed in proportion raw medicinal material each in described pharmaceutical composition, adds the alcohol relative to mixture quality 4 times Concentration is the ethanol of 90%, is heated to reflux 5 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add phase For the ethanol that determining alcohol is 95% of described medicinal residues quality 3 times, it is heated to reflux 2 hours, extracts, filter and obtain the second extracting solution； First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 3 hours by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 500 mesh Micropowders；
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.15 times, 0.25 times of breast Sugar, the starch of 0.3 times, sieve, mix homogeneously, pelletizes, and is dried, and adds relative to 0.03 times of magnesium stearate of micropowders quality, Granulate, tabletting, make.
Wherein, the preparation process of liniment is: take Herba Dracocephali Rupestris 160g, Herba Evolvuli Alsinoides 240g, Herba Veronicae Serpyllifoliae 200g, tart fruit rattan 160g, Herba Saussureae Involueratae 220g, Fructus Liquidambaris 330g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 180g, Folium et Ramulus Callicarpae nudiflorae 160g, trailing plants 340g, mountain leaf 210g, Herb Pararuelliae delavayanae 250g, stone Dragon Rui 30g, ull up field 150g and Herba Hyperici 220g；
The first step, is first ground into coarse powder by described raw medicinal material, further pulverizes, and crosses 100 mesh sieves, enables by 100 mesh sieves Fine powder amount be at least up to 40%, collect and obtain fine powder a by the fine powder of 100 mesh sieves；
Second step, it is impossible to put into multi-function extractor by the coarse powder of 100 mesh sieves and extract twice, add weight portion 9 times for the first time Amount soak by water 2 hours, second time adds weight portion 7 times amount soak by water 2 hours, merges twice decocting liquid, filters to get filtrate；Gained is filtered Liquid heating is concentrated into pasty state, and after putting into the drying of 80 DEG C of baking oven, room temperature cools down, and grinds to form fine powder b；
3rd step, calls in glycerol after being mixed with fine powder b by fine powder a and makes liniment.
Embodiment 2 pharmaceutical composition 2
Pharmaceutical composition 1 of the present invention includes the medicinal liquid of tablet and the external taken orally, and wherein, the manufacturing process of tablet is: take bitter ground Fourth 150g, phyllodium 160g, Radix Notoginseng 200g, Ganoderma 110g, Herba Polygoni Capitati 250g, Lignum Poria 220g, Rhizoma Chuanxiong 300g, Fructus Forsythiae 20g and Radix rubi coreani 230g；
The first step, is mixed in proportion raw medicinal material each in described pharmaceutical composition, adds the alcohol relative to mixture quality 4 times Concentration is the ethanol of 90%, is heated to reflux 5 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add phase For the ethanol that determining alcohol is 95% of described medicinal residues quality 3 times, it is heated to reflux 2 hours, extracts, filter and obtain the second extracting solution； First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 3 hours by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 500 mesh Micropowders；
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.15 times, 0.25 times of breast Sugar, the starch of 0.3 times, sieve, mix homogeneously, pelletizes, and is dried, and adds relative to 0.03 times of magnesium stearate of micropowders quality, Granulate, tabletting, make.
Wherein, the preparation process of medicinal liquid is: take Herba Dracocephali Rupestris 140g, Herba Evolvuli Alsinoides 210g, Herba Veronicae Serpyllifoliae 250g, tart fruit rattan 320g, Herba Saussureae Involueratae 220g, Fructus Liquidambaris 300g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 190g, Folium et Ramulus Callicarpae nudiflorae 230g, trailing plants 330g, mountain leaf 150g, Herb Pararuelliae delavayanae 170g, stone Dragon Rui 30g, ull up field 120g and Herba Hyperici 200g；
It is respectively fed in proportion in pulverizer be ground into powder by raw medicinal material each in described externally-applied medicinal composition, is then fed into Stirring mixing in blender, it is thus achieved that mixture, sends into mixture and decocts 2.5 hours relative to heating in the water of its quality 4 times, Filtering subsequently, it is thus achieved that the first extracting solution, be fed again into by filtering residue in the water relative to its quality 3 times, heating and refluxing extraction 1.5 is little Time, filter subsequently, it is thus achieved that the second extracting solution, the first extracting solution and the second extracting solution merged, it is thus achieved that traditional Chinese medicine composition extract liquid, Being 65 DEG C in temperature, vacuum is to carry out being concentrated in vacuo to portion of water under conditions of 0.08mpa to be evaporated off, it is thus achieved that crude drug concentration Medicinal liquid for 1.5g/ml.
Acute toxicity test: application NIH mice 40, S fully recovers F level, male and female half and half, and body weight 18～25g carries out acute poison Property test.Mice is randomly divided into two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；By the present invention's In embodiment 1-2, the tablet dissolved of preparation is in water, and (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(i.e. unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, between administration 6 hours intervals, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: with Matched group compares, and after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body Heavily increase the most normal.Tablet LD50 > 28.7 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 57.4 lifes Medicine/kg/ day.The pharmaceutical composition clinical application amount of the present invention is 4.6g crude drug/day/people, and adult's body weight, in terms of 60KG, is averagely used Pharmaceutical quantities is 0.077g crude drug/kg/ day.By weighing machine: the medicine group of mice (average weight is in terms of 21g) the oral administration gavage present invention The dosis tolerata of compound is 745 times of quantity.Therefore the pharmaceutical composition acute toxicity of the present invention is low, clinical drug safety.
Toxicity test: be uniformly coated with by depilatory guinea pig back spinal column both sides, makes unhairing scope about 40 square centimeters. Clean depilatory returns cage to observe 24 hours, often group Cavia porcellus smear respectively in the embodiment of the present invention 2 medicinal liquid 0.3 ml of preparation, 0.5 Ml and 0.8ml, respectively 600mg, 1000mg and 1600mg Han crude drug, another group painting every twice-daily of solvent 0.8ml, continuous one In week, after experiment terminates, being put to death by Cavia porcellus, the heart, liver, kidney and depilation skin do pathological examination.Above-mentioned three groups of medication Cavia porcellus trunks take off Hair-fields, has no that local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, extremity live The dynamic matched group no significant difference that waits, histopathologic examination, the administration group heart, liver, kidney and depilation skin compare also without bright with compareing word Significant difference is different.Result is pointed out, and the medicinal liquid of external of the present invention, without local irritant effect, also has no that general toxicity shows.Show the present invention The external medicinal liquid of pharmaceutical composition uses safety.The liniment of preparation in the embodiment of the present invention 1 is carried out toxicity according to the method described above Test, result is consistent with the above results.
Clinical data:
Case selection: select nurse to outpatient service in November, 2014 or 231 example children's's trauma wounds in hospital in November, 2013, The wound size of infant is 1-47cm2, above-mentioned wound is only general epidermis injury (getting rid of skeleton, tendon, blood vessel injury etc.). After wound hemostasis, use the medicine of the present invention that above-mentioned 231 example trauma wounds are nursed；231 example infants are randomly divided into reality Execute example 1 treatment group, embodiment 2 treatment group and matched group, each experimental group 77 people.
Therapeutic Method:
In medication therapy groups:
Embodiment 1 treatment group: use the tablet of the embodiment of the present invention 1 preparation, 3 times on the one, 1 piece/times, use the present invention real simultaneously Execute the liniment yarn pad external application 20 minutes of example 1 preparation, three times a day, within every 7 days, be 1 course for the treatment of；
Embodiment 2 treatment group: use the tablet of the embodiment of the present invention 2 preparation, 3 times on the one, 1 piece/times, use the present invention real simultaneously Execute the medicinal liquid yarn pad external application 20 minutes of example 2 preparation, three times a day, within every 7 days, be 1 course for the treatment of；
Matched group: use povidone iodine yarn pad external application 20 minutes, three times a day, every 7 days be a course for the treatment of.
The standard of curative effect evaluation: effective: wound comes off to incrustation, and the cicatrix color at patient wound is the most thin out (beyond 1 meter Can't see cicatrix)；Effective: wound comes off to incrustation, and the cicatrix color at patient wound is thin out；Invalid: to compare, respectively with before treatment Aspect is all without improving.
Therapeutic outcome:
See Tables 1 and 2, as it can be seen from table 1 use the pharmaceutical composition of clinical infant wound care of the present invention, relatively In conventional medicament on therapeutic effect, have and be markedly improved；From table 2 it can be seen that use clinical infant wound of the present invention The pharmaceutical composition of nursing, relative to conventional medicament, significantly shortens on the course for the treatment of treating.
Table 1 is respectively organized and is treated Clinical efficacy comparison example after 4 courses for the treatment of respectively
Group Number of cases Effective number Significant figure Invalid number Total effective rate (%)
Embodiment 1 treatment group 77 73 2 2 97.4%
Embodiment 2 treatment group 77 77 0 0 100%
Matched group 77 31 26 20 57%
2 four groups of table is effective and efficiently individual quantity time comparative example (%) after treating 4 courses for the treatment of respectively
Group Number of cases 1st course for the treatment of 2nd course for the treatment of 3rd course for the treatment of 4th course for the treatment of
Embodiment 1 treatment group 75 17(22.7%) 18(24%) 19(25.4%) 21(28%)
Embodiment 2 treatment group 77 18(23.4%) 18(23.4%) 20(26%) 21(27.3%)
Matched group 57 3(5.3%) 5(8.8%) 7(12.3%) 42(73.7%)
According to the clinical statistics in above table, the pharmaceutical composition that the present invention provides have rapid-action, effective percentage is high, treat Effect is definite, safety high, have no side effect；Simultaneously effective to treatment group and 152 examples of efficiently individual quantity and matched group is effective and Effective 57 example follow-up of patients 1 year half, result statistics, in embodiment 1 treatment group 75 example, effective 73 examples are without infecting, in effective 2 examples Infecting 1 example, infection rate is 1.33%；All without infecting in effective 77 in embodiment 2 treatment group 77 example, infection rate is 0%；Matched group shows Effect and efficiently individual quantity 57 example, infect 7 examples, infect 9 examples, infection rate in effective 26 example patients in 31 effective example patients 28.07%；Above-mentioned infection refer to patient outcomes reach effective or effectively after, substantially occur infecting disease in 1 year half followed up a case by regular visits to Shape.
Model case: Wang, women, 5 years old, when patient is at play, shank imprudence was stabbed by bottle glass, wound 3* 5cm, clearing glass removes and after hemostasis, uses the tablet in embodiment 1 treatment group, and 3 times on the one, 1 piece/times, the oral present invention implements The tablet of example 1 preparation, 3 times on the one, 1 piece/times, the liniment yarn pad external application simultaneously used 20 minutes, three times a day, half treatment of medication Journey incrustation comes off, and infection symptoms does not the most occur, half a year " Invest, Then Investigate ", the wound cicatrix color of patient light (1 meter with Can't see outward cicatrix).
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (7)

1. the pharmaceutical composition of a clinical infant wound care, it is characterised in that by oral medicament composition and medicine for external use Compositions forms, and described oral medicament composition is made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 12-24 weight Part, phyllodium 14-28 weight portion, Radix Notoginseng 11-21 weight portion, Ganoderma 9-18 weight portion, Herba Polygoni Capitati 12-32 weight portion, Lignum Poria 15-25 weight portion, Rhizoma Chuanxiong 13-33 weight portion, Fructus Forsythiae 2-4 weight portion and Radix rubi coreani 15-35 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris's 10-20 weight portion, Herba Evolvuli Alsinoides 14-28 weight portion, Herba Veronicae Serpyllifoliae 16-32 weight portion, tart fruit rattan 15-35 weight portion, Herba Saussureae Involueratae 14-26 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 16-22 Weight portion, Folium et Ramulus Callicarpae nudiflorae 15-26 weight portion, trailing plants 15-35 weight portion, mountain leaf 11-24 weight portion, Herb Pararuelliae delavayanae 13-31 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3-5 weight portion, ull up field 9-18 weight portion and Herba Hyperici 10-25 weight portion.
The pharmaceutical composition of clinical infant wound care the most according to claim 1, it is characterised in that described oral medicine Compositions is made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 14-22 weight portion, phyllodium 15-25 weight portion, Radix Notoginseng 14-20 weight portion, Ganoderma 10-16 weight portion, Herba Polygoni Capitati 14-30 weight portion, Lignum Poria 16-24 weight portion, Rhizoma Chuanxiong 15-30 weight Part, Fructus Forsythiae 2-3 weight portion and Radix rubi coreani 16-34 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris's 12-20 weight portion, Herba Evolvuli Alsinoides 15-25 weight portion, Herba Veronicae Serpyllifoliae 18-30 weight portion, tart fruit rattan 15-35 weight portion, Herba Saussureae Involueratae 15-24 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 18-20 Weight portion, Folium et Ramulus Callicarpae nudiflorae 15-24 weight portion, trailing plants 15-34 weight portion, mountain leaf 12-22 weight portion, Herb Pararuelliae delavayanae 13-30 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3-4 weight portion, ull up field 10-16 weight portion and Herba Hyperici 10-24 weight portion.
The pharmaceutical composition of clinical infant wound care the most according to claim 1 and 2, it is characterised in that in described Compositions of taking medicine is made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 20 weight portion, phyllodium 18 weight portion, Radix Notoginseng 16 Weight portion, Ganoderma 15 weight portion, Herba Polygoni Capitati 22 weight portion, Lignum Poria 18 weight portion, Rhizoma Chuanxiong 30 weight portion, Fructus Forsythiae 2 weight portion and Radix rubi coreani 33 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris 16 weight portion, Herba Evolvuli Alsinoides 24 weight Amount part, Herba Veronicae Serpyllifoliae 20 weight portion, tart fruit rattan 16 weight portion, Herba Saussureae Involueratae 22 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 18 weight portion, Folium et Ramulus Callicarpae nudiflorae 16 weight Part, trailing plants 34 weight portion, mountain leaf 21 weight portion, Herb Pararuelliae delavayanae 25 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3 weight portion, ull up field 15 weight portion and Herba Hyperici 22 weight portion.
4. according to the pharmaceutical composition of the clinical infant wound care described in any one of claim 1-3, it is characterised in that institute State oral medicament composition to be made up of the raw medicinal material of following parts by weight: Herba Corydalis Bungeanae 15 weight portion, phyllodium 16 weight portion, three 7 20 weight portions, Ganoderma 11 weight portion, Herba Polygoni Capitati 25 weight portion, Lignum Poria 22 weight portion, Rhizoma Chuanxiong 30 weight portion, Fructus Forsythiae 2 weight Part and Radix rubi coreani 23 weight portion；
Described externally-applied medicinal composition is made up of the raw medicinal material of following parts by weight: Herba Dracocephali Rupestris 14 weight portion, Herba Evolvuli Alsinoides 21 weight Amount part, Herba Veronicae Serpyllifoliae 25 weight portion, tart fruit rattan 32 weight portion, Herba Saussureae Involueratae 22 weight portion, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 19 weight portion, Folium et Ramulus Callicarpae nudiflorae 23 weight Part, trailing plants 33 weight portion, mountain leaf 15 weight portion, Herb Pararuelliae delavayanae 17 weight portion, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 3 weight portion, ull up field 12 weight portion and Herba Hyperici 20 weight portion.
5. the pharmaceutical composition of the clinical infant wound care described in an any one of claim 1-4, it is characterised in that when When the dosage form of described oral medicament composition is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described pharmaceutical composition raw medicinal material, adds relative to mixture quality 3～5 times Determining alcohol is the ethanol of 85%～95%, is heated to reflux 4～6 hours, extracts, and filters and obtains the first extracting solution；Filter the medicine obtained Slag adds the ethanol that determining alcohol is 90%～95% relative to described medicinal residues quality 2～4 times, is heated to reflux 1～3 hour, carries Take, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, Obtain and get dry extract；
Second step, is placed in super micron mill pulverizing 1～3 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 400 Mesh～the micropowders of 500 mesh；
3rd step, the micropowders that second step is obtained, add relative to its quality 0.1～the microcrystalline Cellulose of 0.2 times, 0.15 ～0.3 times of lactose, starch of 0.2～0.3 times, sieve, mix homogeneously, pelletize, be dried, add relative to micropowders quality 0.025～0.04 times of magnesium stearate, granulate, tabletting, make.
6. the pharmaceutical composition of the clinical infant wound care described in an any one of claim 1-4, it is characterised in that when When the dosage form of described externally-applied medicinal composition is liniment, its preparation method comprises the following steps:
The first step, is first ground into coarse powder by described raw medicinal material, further pulverizes, and crosses 100 mesh sieves, enables by 100 mesh sieves Fine powder amount be at least up to 40%, collect and obtain fine powder a by the fine powder of 100 mesh sieves；
Second step, it is impossible to put into multi-function extractor by the coarse powder of 100 mesh sieves and extract twice, add weight portion 8-10 for the first time Times amount soak by water 1-3 hour, second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to obtain filter Liquid；The heating of gained filtrate is concentrated into pasty state, and after putting into the drying of 80 DEG C of baking oven, room temperature cools down, and grinds to form fine powder b；
3rd step, calls in glycerol after being mixed with fine powder b by fine powder a and makes liniment.
7. the pharmaceutical composition of the clinical infant wound care described in an any one of claim 1-4, it is characterised in that when When the dosage form of described externally-applied medicinal composition is medicinal liquid, its preparation method comprises the following steps: by described externally-applied medicinal composition In each raw medicinal material be respectively fed in proportion in pulverizer be ground into powder, be then fed in blender stirring mixing, it is thus achieved that mixed Compound, sends into mixture and decocts 2-3 hour relative to heating in the water of its quality 3-5 times, filter subsequently, it is thus achieved that first carries Take liquid, filtering residue is fed again into relative in the water of its quality 2-4 times, heating and refluxing extraction 1-2 hour, filters subsequently, it is thus achieved that Second extracting solution, merges the first extracting solution and the second extracting solution, it is thus achieved that traditional Chinese medicine composition extract liquid, is 60-70 in temperature DEG C, vacuum is to carry out being concentrated in vacuo to portion of water under conditions of 0.08-0.1mpa to be evaporated off, it is thus achieved that crude drug concentration is 1g/ The medicinal liquid of ml-2g/ml.
CN201610306982.6A 2016-05-11 2016-05-11 Pharmaceutical composition for clinical children wound care and preparation method thereof Withdrawn CN105878447A (en)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘绍贵等: "《中药处方手册》", 31 December 2003 *

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