CN105853825A - Traditional Chinese medicine composition gel for treating rheumatic arthritis and preparation method of traditional Chinese medicine composition gel - Google Patents
Traditional Chinese medicine composition gel for treating rheumatic arthritis and preparation method of traditional Chinese medicine composition gel Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 81
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 201000003068 rheumatic fever Diseases 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 45
- 241000255789 Bombyx mori Species 0.000 claims abstract description 17
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 15
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000008367 deionised water Substances 0.000 claims abstract description 15
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 15
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 15
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960000502 poloxamer Drugs 0.000 claims abstract description 14
- 229920001983 poloxamer Polymers 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 9
- 241000411851 herbal medicine Species 0.000 claims abstract description 8
- 210000000582 semen Anatomy 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 8
- 238000005538 encapsulation Methods 0.000 claims description 5
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 5
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 230000006866 deterioration Effects 0.000 abstract description 4
- 238000004108 freeze drying Methods 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 2
- 238000000465 moulding Methods 0.000 abstract 4
- 241000382455 Angelica sinensis Species 0.000 abstract 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 2
- 244000077995 Coix lacryma jobi Species 0.000 abstract 2
- 235000007354 Coix lacryma jobi Nutrition 0.000 abstract 2
- 235000017045 Dioscorea septemloba Nutrition 0.000 abstract 2
- 241000908492 Dioscorea septemloba Species 0.000 abstract 2
- 241000501743 Gentiana macrophylla Species 0.000 abstract 2
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 2
- 240000000249 Morus alba Species 0.000 abstract 2
- 235000008708 Morus alba Nutrition 0.000 abstract 2
- 244000236658 Paeonia lactiflora Species 0.000 abstract 2
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 2
- 240000003801 Sigesbeckia orientalis Species 0.000 abstract 2
- 235000003407 Sigesbeckia orientalis Nutrition 0.000 abstract 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 2
- 235000011477 liquorice Nutrition 0.000 abstract 2
- 230000029087 digestion Effects 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
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- 230000001225 therapeutic effect Effects 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 241000736199 Paeonia Species 0.000 description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010037714 Quadriplegia Diseases 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003356 anti-rheumatic effect Effects 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 230000007812 deficiency Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000007119 pathological manifestation Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
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- 210000001835 viscera Anatomy 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention relates to traditional Chinese medicine composition gel for treating rheumatic arthritis and a preparation method of the traditional Chinese medicine composition gel. The traditional Chinese medicine composition gel consists of a traditional Chinese medicine extract and a gel molding agent, wherein the traditional Chinese medicine extract is prepared from the following traditional Chinese herbal medicines in parts by weight: 8-15 parts of mulberry twigs, 6-12 parts of honeysuckle stems, 5-12 parts of paeonia lactiflora, 6-8 parts of dioscorea septemloba, 8-12 parts of gentiana macrophylla, 6-10 parts of angelica sinensis, 5-12 parts of silkworm excrement, 7-16 parts of siegesbeckia orientalis, 5-8 parts of coix lacryma-jobi and 6-10 parts of liquorice; the gel molding agent consists of deionized water, hyaluronic acid and poloxamer; the medicines and the gel molding agent are stored separately, and are uniformly mixed according to an appropriate ratio when being used. The traditional Chinese medicine composition gel is prepared from reasonably selected mulberry twigs, honeysuckle stems, paeonia lactiflora, dioscorea septemloba, gentiana macrophylla, angelica sinensis, silkworm excrement, siegesbeckia orientalis, coix lacryma-jobi and liquorice in manners of digestion, concentration and freeze-drying, then dry powder which is low in probability of caking and long in expiration date can be prepared, effective components can be prevented from high probability of oxidative deterioration, the traditional Chinese medicines are uniformly mixed with the gel molding agent according to a ratio, then gel can be prepared, and the gel is made and used immediately, so that very high medicinal activity can be maintained, and the gel is very convenient to use and good in treatment effect.
Description
Technical field
The present invention relates to a kind of drug gel and preparation method thereof, more particularly to a kind of rheumatic arthritis for the treatment of
Chinese medicine composition gel and preparation method thereof.
Background technology
Rheumatic arthritis is common clinical, frequently-occurring disease, and its cause of disease is complicated, and pathological manifestations is various, and the touching difficulty of the course of disease heals,
Even make people disable, disability, severely compromise the healthy of the people.Existing antirheumatic, mainly has non-
Steroidal anti-inflammatory medicine, adrenocortical steroid and immunosuppressant etc., they mostly can only relief of symptoms, and the state of an illness can not be stoped
Development.
This type of disease is belonged to arthromyodynia category by Chinese medicine.Arthromyodynia is due to exopathogen such as human righteousness are not enough, wind and cold is damp and hot
Invasion and attack；Or interior raw phlegm-damp, pyretic toxicity, blood stasis cause passages through which vital energy circulates group to block, occur weighing with limbs joint, myalgia, numb swollen
Swollen, joint stuffiness, even joint deformity, or involve the general name of the class disease that internal organs are characterized.
Summary of the invention
It is an object of the invention to solve the deficiencies in the prior art, it is provided that a kind of Chinese medicine composition treating rheumatic arthritis
Thing gel.
Further object is that the preparation that a kind of Chinese medicine composition gel treating rheumatic arthritis is provided
Method.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of Chinese medicine composition gel treating rheumatic arthritis, described Chinese medicine composition gel is by Chinese medicine extract and gel
Forming agent forms, and described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Ramulus Mori 8-15 part, Caulis Lonicerae 6-12
Part, Radix Paeoniae Alba 5-12 part, Bi 6-8 part, Radix Gentianae Macrophyllae 8-12 part, Radix Angelicae Sinensis 6-10 part, silkworm excrement 5-12 part, Herba Siegesbeckiae 7-16 part, Semen Coicis
Core 5-8 part, Radix Glycyrrhizae 6-10 part, described gel forming agent is made up of deionized water, hyaluronic acid and poloxamer, Chinese medicine extract
Separately store with gel forming agent, with suitable ratio mix homogeneously both during use.
Ramulus Mori: wind-damp dispelling, profit joint, row aqueous vapor；
Caulis Lonicerae: there is heat-clearing and toxic substances removing, the curative effect of dispelling wind dredging collateral；
Herba Siegesbeckiae: have removing toxic substances, analgesic activity, controls systemic pain, quadriplegia；
Bi: dampness removing goes turbid, wind expelling stagnation removing；
Radix Gentianae Macrophyllae: wind-damp dispelling, clearing away damp-heat, stopping numbness pain；
Semen Coicis: rheumatism body pain can be alleviated.
Rational choice of the present invention Ramulus Mori, Caulis Lonicerae, the Radix Paeoniae Alba, Bi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, silkworm excrement, Herba Siegesbeckiae, Semen Coicis
And Radix Glycyrrhizae, compatibility is reasonable, assists logical effect, play curative effect between medicine, obtains dry powder, individually by extraction, concentration, lyophilization
Sealing up for safekeeping, prevented from caking, effective ingredient is difficult to oxidation deterioration, long shelf-life, mixes in proportion with gel forming agent during use
Become gel, existing mixed existing use, keep high pharmaceutically active, be coated at patient articular, very easy to use, due in gel
Shape, lock aqueous is good, and the most volatile exsiccation, effective ingredient can be released slowly into for a long time and reach focus, and therapeutic effect is good.
Preferably, described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Ramulus Mori 10 parts, Caulis Lonicerae 10
Part, the Radix Paeoniae Alba 8 parts, Bi 7 parts, Radix Gentianae Macrophyllae 10 parts, Radix Angelicae Sinensis 8 parts, silkworm excrement 8 parts, Herba Siegesbeckiae 12 parts, Semen Coicis 6 parts, 8 parts of Radix Glycyrrhizae.
Preferably, the percentage by weight composition of described gel forming agent is as follows: hyaluronic acid 0.6-0.8%, poloxamer
20-25%, surplus is deionized water.
Preferably, the percentage by weight composition of described gel forming agent is as follows: hyaluronic acid 0.7%, and poloxamer 22% is remaining
Amount is deionized water.
Preferably, the proportioning of described Chinese medicine extract and gel forming agent is as follows: every 30-40g Chinese medicine extract joins 100-
120ml gel forming agent, the two is uniformly mixed under room temperature.
A kind of preparation method of the Chinese medicine composition gel treating rheumatic arthritis:
A () prepares Chinese medicine extract: the Ramulus Mori of formula ratio, Caulis Lonicerae, the Radix Paeoniae Alba, Bi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, silkworm excrement, Herba Siegesbeckiae,
Semen Coicis and Radix Glycyrrhizae, add the ethanol water of 150 ~ 200ml volume fraction 70-75%, little in 100-110 DEG C of backflow extraction 2-5
Time, lixiviating solution is through being concentrated in vacuo postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, envelope
Dress；
Chinese medicine extract and gel forming agent separately store, and with suitable proportion mix homogeneously both during use, hybrid mode is will
Chinese medicine extract adds in gel forming agent, stirring while adding.
The invention has the beneficial effects as follows: Rational choice of the present invention Ramulus Mori, Caulis Lonicerae, the Radix Paeoniae Alba, Bi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis,
Silkworm excrement, Herba Siegesbeckiae, Semen Coicis and Radix Glycyrrhizae, obtain dry powder by extraction, concentration, lyophilization, individually seal up for safekeeping, prevented from caking, have
Effect composition is difficult to oxidation deterioration, long shelf-life, mixes in proportion into gel with gel forming agent during use, existing mixed existing use,
Keep high pharmaceutically active, be coated at patient articular, very easy to use, owing in gel, lock aqueous is good, is difficult to wave
Sending out and become dry, effective ingredient can be released slowly into for a long time and reach focus, and therapeutic effect is good.
Detailed description of the invention
Below by specific embodiment, technical scheme is described in further detail.
Embodiment 1:
A kind of Chinese medicine composition gel treating rheumatic arthritis, described Chinese medicine composition gel is by Chinese medicine extract and gel
Forming agent forms, and described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Ramulus Mori 8 parts, Caulis Lonicerae 6 parts, the Radix Paeoniae Alba 5
Part, Bi 6 parts, Radix Gentianae Macrophyllae 8 parts, Radix Angelicae Sinensis 6 parts, silkworm excrement 5 parts, Herba Siegesbeckiae 7 parts, Semen Coicis 5 parts, 6 parts of Radix Glycyrrhizae, described gel forming
The percentage by weight composition of agent is as follows: hyaluronic acid 0.6%, poloxamer 20%, surplus is deionized water；
The preparation method of described Chinese medicine composition gel is as follows:
A () prepares Chinese medicine extract: the Ramulus Mori of formula ratio, Caulis Lonicerae, the Radix Paeoniae Alba, Bi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, silkworm excrement, Herba Siegesbeckiae,
Semen Coicis and Radix Glycyrrhizae, add the ethanol water of 150ml volume fraction 75%, and in 110 DEG C of backflow extractions 2 hours, lixiviating solution was through true
Empty concentration postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, envelope
Dress；
Chinese medicine extract and gel forming agent separately store, and with suitable proportion mix homogeneously both during use, hybrid mode is will
Chinese medicine extract adds in gel forming agent, and stirring while adding, every 30g Chinese medicine extract joins 100ml gel forming agent, the two
It is uniformly mixed under room temperature.
Embodiment 2:
A kind of Chinese medicine composition gel treating rheumatic arthritis, described Chinese medicine composition gel is by Chinese medicine extract and gel
Forming agent forms, and described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Ramulus Mori 15 parts, Caulis Lonicerae 12 parts, in vain
Chinese herbaceous peony 12 parts, Bi 8 parts, Radix Gentianae Macrophyllae 12 parts, Radix Angelicae Sinensis 10 parts, silkworm excrement 12 parts, Herba Siegesbeckiae 16 parts, Semen Coicis 8 parts, 10 parts of Radix Glycyrrhizae, institute
The percentage by weight composition stating gel forming agent is as follows: hyaluronic acid 0.8%, poloxamer 25%, surplus is deionized water；
The preparation method of described Chinese medicine composition gel is as follows:
A () prepares Chinese medicine extract: the Ramulus Mori of formula ratio, Caulis Lonicerae, the Radix Paeoniae Alba, Bi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, silkworm excrement, Herba Siegesbeckiae,
Semen Coicis and Radix Glycyrrhizae, add the ethanol water of 200ml volume fraction 70%, and in 100 DEG C of backflow extractions 5 hours, lixiviating solution was through true
Empty concentration postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, envelope
Dress；
Chinese medicine extract and gel forming agent separately store, and with suitable proportion mix homogeneously both during use, hybrid mode is will
Chinese medicine extract adds in gel forming agent, and stirring while adding, every 40g Chinese medicine extract joins 120ml gel forming agent, the two
It is uniformly mixed under room temperature.
Embodiment 3:
A kind of Chinese medicine composition gel treating rheumatic arthritis, described Chinese medicine composition gel is by Chinese medicine extract and gel
Forming agent forms, and described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Ramulus Mori 10 parts, Caulis Lonicerae 10 parts, in vain
Chinese herbaceous peony 8 parts, Bi 7 parts, Radix Gentianae Macrophyllae 10 parts, Radix Angelicae Sinensis 8 parts, silkworm excrement 8 parts, Herba Siegesbeckiae 12 parts, Semen Coicis 6 parts, 8 parts of Radix Glycyrrhizae, described solidifying
The percentage by weight composition of gum forming agent is as follows: hyaluronic acid 0.7%, poloxamer 22%, surplus is deionized water；
The preparation method of described Chinese medicine composition gel is as follows:
A () prepares Chinese medicine extract: the Ramulus Mori of formula ratio, Caulis Lonicerae, the Radix Paeoniae Alba, Bi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, silkworm excrement, Herba Siegesbeckiae,
Semen Coicis and Radix Glycyrrhizae, add the ethanol water of 180ml volume fraction 75%, and in 105 DEG C of backflow extractions 3 hours, lixiviating solution was through true
Empty concentration postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, envelope
Dress；
Chinese medicine extract and gel forming agent separately store, and with suitable proportion mix homogeneously both during use, hybrid mode is will
Chinese medicine extract adds in gel forming agent, and stirring while adding, every 35g Chinese medicine extract joins 110ml gel forming agent, the two
It is uniformly mixed under room temperature.
Chinese medicine composition gel for treating rheumatic arthritis 60 example prepared by embodiment of the present invention 1-3, wherein
Man's 30 examples, female 30 example；The oldest 60 years old, minimum 25 years old, average 40 years old；The course of disease is the shortest 8 months, the longest
10 years, average 4.2 years, it is randomly divided into 3 groups, uses the Chinese medicine composition gel of embodiment 1-3 respectively；
Therapeutic Method: the Chinese medicine composition gel newly joined is evenly applied to affected part, coats 4 every day,
After treating 2 months, detect every observation item: morning deadlock, that articular pain index, waist stretch mobility in the wrong, waist lateral bending is movable
Degree, and paired observation curative effect front with treatment.
Criterion of therapeutical effect, clinical cure: symptom all disappears, functional activity is all normal, and main physical and chemical index etc. is the most just
Often；Effective: symptomatology or cardinal symptom disappear, and function of joint is recovered substantially, normal work and work can be participated in, mainly manage
Change index normal, take a turn for the better: cardinal symptom all disappears, and function of joint is substantially recovered or is clearly better, and can't take care of oneself
Transferring self-care to, work work capacity has been recovered, invalid: compare each side with before treatment all without progressive.
| Cure | Effective | Take a turn for the better | Invalid | Total effective rate | |
| Embodiment 1 | 14 | 2 | 2 | 2 | 90% |
| Embodiment 2 | 14 | 3 | 1 | 2 | 90% |
| Embodiment 3 | 16 | 2 | 1 | 1 | 98.5% |
In sum, Rational choice of the present invention Ramulus Mori, Caulis Lonicerae, the Radix Paeoniae Alba, Bi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, silkworm excrement, Xian
Grass, Semen Coicis and Radix Glycyrrhizae, obtain dry powder by extraction, concentration, lyophilization, individually seal up for safekeeping, prevented from caking, and effective ingredient is difficult to
Oxidation deterioration, long shelf-life, mix in proportion into gel with gel forming agent during use, existing mixed existing use, keep high
Pharmaceutically active, is coated at patient articular, very easy to use, owing in gel, lock aqueous is good, the most volatile exsiccation, medicine
Thing effective ingredient can be released slowly into for a long time and reach focus, and therapeutic effect is good.
Embodiment described above is the one preferably scheme of the present invention, not makees the present invention any pro forma
Limit, on the premise of without departing from the technical scheme described in claim, also have other variant and remodeling.
Claims (6)
1. the Chinese medicine composition gel treating rheumatic arthritis, it is characterised in that: described Chinese medicine composition gel by
Medicament extract and gel forming agent composition, described Chinese medicine extract is processed by the Chinese herbal medicine of following weight portion: Ramulus Mori 8-15
Part, Caulis Lonicerae 6-12 part, Radix Paeoniae Alba 5-12 part, Bi 6-8 part, Radix Gentianae Macrophyllae 8-12 part, Radix Angelicae Sinensis 6-10 part, silkworm excrement 5-12 part, Xian
Grass 7-16 part, Semen Coicis 5-8 part, Radix Glycyrrhizae 6-10 part, described gel forming agent is by deionized water, hyaluronic acid and poloxamer group
Becoming, Chinese medicine extract and gel forming agent separately store, with suitable ratio mix homogeneously both during use.
The Chinese medicine composition gel for the treatment of rheumatic arthritis the most according to claim 1, it is characterised in that: described Chinese medicine
Extract is processed by the Chinese herbal medicine of following weight portion: Ramulus Mori 10 parts, Caulis Lonicerae 10 parts, the Radix Paeoniae Alba 8 parts, Bi 7 parts, Radix Gentianae Macrophyllae 10
Part, Radix Angelicae Sinensis 8 parts, silkworm excrement 8 parts, Herba Siegesbeckiae 12 parts, Semen Coicis 6 parts, 8 parts of Radix Glycyrrhizae.
The Chinese medicine composition gel for the treatment of rheumatic arthritis the most according to claim 1, it is characterised in that: described gel
The percentage by weight composition of forming agent is as follows: hyaluronic acid 0.6-0.8%, poloxamer 20-25%, surplus is deionized water.
The Chinese medicine composition gel for the treatment of rheumatic arthritis the most according to claim 3, it is characterised in that: described gel
The percentage by weight composition of forming agent is as follows: hyaluronic acid 0.7%, poloxamer 22%, surplus is deionized water.
The Chinese medicine composition gel for the treatment of rheumatic arthritis the most according to claim 1, it is characterised in that: described Chinese medicine
The proportioning of extract and gel forming agent is as follows: every 30-40g Chinese medicine extract joins 100-120ml gel forming agent, and the two is in often
It is uniformly mixed under temperature.
6. the preparation side of the Chinese medicine composition gel of the treatment rheumatic arthritis described in a claim 1-5 any one
Method, it is characterised in that:
A () prepares Chinese medicine extract: the Ramulus Mori of formula ratio, Caulis Lonicerae, the Radix Paeoniae Alba, Bi, Radix Gentianae Macrophyllae, Radix Angelicae Sinensis, silkworm excrement, Herba Siegesbeckiae,
Semen Coicis and Radix Glycyrrhizae, add the ethanol water of 150 ~ 200ml volume fraction 70-75%, little in 100-110 DEG C of backflow extraction 2-5
Time, lixiviating solution is through being concentrated in vacuo postlyophilization, it is thus achieved that Chinese medicine extract freezing dry powder, encapsulation；
B () prepares gel forming agent: by the deionized water mix homogeneously of the hyaluronic acid of formula ratio, poloxamer and room temperature, envelope
Dress；
Chinese medicine extract and gel forming agent separately store, and with suitable proportion mix homogeneously both during use, hybrid mode is will
Chinese medicine extract adds in gel forming agent, stirring while adding.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610333972.1A CN105853825A (en) | 2016-05-19 | 2016-05-19 | Traditional Chinese medicine composition gel for treating rheumatic arthritis and preparation method of traditional Chinese medicine composition gel |
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| CN201610333972.1A CN105853825A (en) | 2016-05-19 | 2016-05-19 | Traditional Chinese medicine composition gel for treating rheumatic arthritis and preparation method of traditional Chinese medicine composition gel |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114173760A (en) * | 2019-08-01 | 2022-03-11 | 河唯真 | Composition comprising hyaluronic acid and pluronic for preventing or treating joint and cartilage damage |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102886003A (en) * | 2012-10-31 | 2013-01-23 | 石欣 | Traditional Chinese medicine composition for treating rheumatoid arthritis |
-
2016
- 2016-05-19 CN CN201610333972.1A patent/CN105853825A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102886003A (en) * | 2012-10-31 | 2013-01-23 | 石欣 | Traditional Chinese medicine composition for treating rheumatoid arthritis |
Non-Patent Citations (1)
| Title |
|---|
| 刘建平: "袁占盈分型辨治痹证经验案例浅析", 《中国中医基础医学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114173760A (en) * | 2019-08-01 | 2022-03-11 | 河唯真 | Composition comprising hyaluronic acid and pluronic for preventing or treating joint and cartilage damage |
| CN114173760B (en) * | 2019-08-01 | 2024-10-15 | 麦迪可瑞尼亚有限公司 | Composition for preventing or treating joint and cartilage injury comprising hyaluronic acid and pluronic |
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