CN105853290B - 一种皮肤纾敏液及其制备方法和应用 - Google Patents
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Abstract
本发明涉及一种皮肤纾敏液及其制备方法和应用。所述制备方法包括将三七10～20份、地肤子10～20份、野菊花10～18份、丹参8～12份、金银花叶6～10份、虎杖根6～15份加水微波萃取提取，向萃取液中加入冰片至其浓度为0.1％。该皮肤纾敏液可用于制备治疗或预防过敏的化妆品，例如液体喷雾剂或乳液。所述的过敏症状包括瘙痒、湿疹、红肿，体液渗出症状中的一种或多种。
Description
技术领域
本发明涉及一种皮肤纾敏液及其制备方法和应用 ，属于化妆品领域。
背景技术
皮肤过敏是一种很常见的过敏形式，有20％的人有皮肤过敏现象。皮肤过敏又称为“敏感性”皮肤。从医学角度讲，皮肤过敏主要是指当皮肤受到各种刺激如不良反应的化妆品、化学制剂、花粉、某些食品、污染的空气等等，导致皮肤出现红肿、发痒、脱皮及过敏性皮炎等异常现象。
长期以来，抗组胺药在治疗皮肤过敏和瘙痒症中起到了重要的作用，并得到临床广泛应用。但几乎所有的抗组胺药物均具有嗜睡等中枢神经系统活性不良反应，给患者的生活和学习带来了不便，且长期使用容易产生依赖性，过量服用还可能导致严重心血管风险。寻找一种安全性高、不良反应低的抗过敏产品已经成为广大过敏患者和瘙痒症患者的共同诉求。
专利申请CN 104721098 A公开了一种皮肤舒敏液及其制备方法和应用，其是以野菊全株、野生常春藤茎/叶、金缕梅茎/叶、春黄菊花/叶、金花茶叶、落地生根茎 /叶六种植物为原料，经洗净、粉碎、热水浸提、高岭土吸附、静置、压滤、超滤等步骤，得到精致复合提取液。CN 105456420 A公开了一种治疗皮肤过敏的中药组合物，该组合物成份为：冰片、黄芪、防风、白术、甘草、艾草、黄莲、地榆、徐长卿、野菊花、马齿苋、薄荷、连翘。上述中药对于治疗皮肤过敏、皮肤瘙痒、热性皮肤病等症状具有显著疗效，具有抗过敏、抗菌消炎、清凉止痒等作用。上述两篇专利申请中虽然对过敏症状均具有一定的缓解作用，但由于配方不同以及提取方法的局限，抗过敏的药效成分在制备过程中损失较大，导致其抗过敏效果欠佳，且不良反应率较高。
发明内容
针对现有技术中抗组胺类化学药物的毒副作用较大，而现有市售的采用中药提取获取的化妆品或药物的疗效欠佳且不良反应较大的技术不足，本发明提供一种皮肤纾敏液及其制备方法，该皮肤纾敏液通过确定合适的中药材组分，并利用微波提取和乙醇水溶液提取的结合方法制备得到有效抗过敏组分，协助以冰片对过敏症状可以起到很好的治疗和预防效果，且其不良反应低，具有很好的市场前景。
本发明通过下述技术方案实现上述技术目的：
一种皮肤纾敏液的制备方法，其包括如下具体步骤：
1)称取三七10～20份、地肤子10～20份、野菊花10～18份、丹参8～12份、金银花叶6～10份、虎杖根6～15份，洗净后切片、干燥、粉碎，得到80目～120目干粉；
2)将干粉加纯化水溶解，然后采用微波萃取提取，过滤得到一次提取液，滤渣备用；其中，所述纯化水与所述干粉的质量比为6～8∶1，所述微波萃取功率为800 瓦～950瓦，微波萃取时间为2min～6min；
3)将滤渣使用体积比为60～80％的乙醇水溶液浸提40min～60min，过滤得到二次提取液；其中乙醇水溶液与滤渣的质量体积比为1∶4～6，浸提过程中的提取温度为70℃～90℃；
4)合并一次提取液和二次提取液得到粗提取液，将所述粗提取液通入离子交换树脂塔进行脱色处理，得到精提取液；其中，脱色时间为2.5h～4h；
5)将精提取液减压浓缩原体积的1/6～1/8，超滤膜过滤后向其中加入冰片至其浓度为0.1％，即可得到皮肤纾敏液。
优选地，上述所述的皮肤纾敏液的制备方法中的原材料的重量份数比为三七15份、地肤子15份、野菊花14份、丹参10份、金银花叶8份、虎杖根11份。该配方比例的原材料提取得到的提取液的抗过敏性能更好。
优选地，上述所述的制备方法中纯化水与所述干粉的质量比为7∶1。
优选地，上述所述的皮肤纾敏液的制备方法中微波萃取功率为900瓦，微波萃取时间为4min。
优选地，上述所述的皮肤纾敏液的制备方法中，所述的乙醇水溶液体积浓度为70％，所述的乙醇水溶液与滤渣的质量体积比为1∶5，且浸提过程中的提取温度为 80℃。
优选地，上述所述的皮肤纾敏液的制备方法中加入冰片前将精提取液减压浓缩原体积的1/7。
本发明还请求保护由上述制备方法制备得到的皮肤纾敏液。
本发明还请求保护上述制备方法制备得到的皮肤纾敏液在制备治疗或预防抗过敏化妆品中的应用。该皮肤纾敏液可制成液体喷雾剂直接喷洒于皮肤过敏部位，或制成乳液涂布于皮肤过敏部位。所述的过敏症状包括瘙痒、湿疹、红肿，体液渗出症状中的一种或多种。
具体实施方式
以下通过具体实施例进一步说明本发明，但本发明的保护范围并不局限于下述实施例。
实施例1
一种皮肤纾敏液，其采用如下制备方法制备得到：
1)称取三七10份、地肤子10份、野菊花10份、丹参8份、金银花叶6份、虎杖根 6份，洗净后切片、干燥、粉碎，得到80目干粉；
2)将干粉加纯化水溶解，然后采用微波萃取提取，过滤得到一次提取液，滤渣备用；其中，所述纯化水与所述干粉的质量比为6∶1，所述微波萃取功率为800瓦，微波萃取时间为2min；
3)将滤渣使用体积比为60％的乙醇水溶液浸提40min，过滤得到二次提取液；其中乙醇水溶液与滤渣的质量体积比为1∶4，浸提过程中的提取温度为70℃；
4)合并一次提取液和二次提取液得到粗提取液，将所述粗提取液通入离子交换树脂塔进行脱色处理，得到精提取液；其中，脱色时间为2.5h；
5)将精提取液减压浓缩原体积的1/6，超滤膜过滤后向其中加入冰片至浓度为0.1％，即可得到皮肤纾敏液。
实施例2
一种皮肤纾敏液，其采用如下制备方法制备得到：
1)称取三七20份、地肤子20份、野菊花18份、丹参12份、金银花叶10份、虎杖根15份，洗净后切片、干燥、粉碎，得到120目干粉；
2)将干粉加纯化水溶解，然后采用微波萃取提取，过滤得到一次提取液，滤渣备用；其中，所述纯化水与所述干粉的质量比为8∶1，所述微波萃取功率为950瓦，微波萃取时间为6min；
3)将滤渣使用体积比为60～80％的乙醇水溶液浸提60min，过滤得到二次提取液；其中乙醇水溶液与滤渣的质量体积比为1∶6，浸提过程中的提取温度为90℃；
4)合并一次提取液和二次提取液得到粗提取液，将所述粗提取液通入离子交换树脂塔进行脱色处理，得到精提取液；其中，脱色时间为4h；
5)将精提取液减压浓缩原体积的1/8，超滤膜过滤后向其中加入冰片至浓度为0.1％，即可得到皮肤纾敏液。
实施例3
一种皮肤纾敏液，其采用如下制备方法制备得到：
1)称取三七15份、地肤子15份、野菊花14份、丹参10份、金银花叶8份、虎杖根11份，洗净后切片、干燥、粉碎，得到100目干粉；
2)将干粉加纯化水溶解，然后采用微波萃取提取，过滤得到一次提取液，滤渣备用；其中，所述纯化水与所述干粉的质量比为7∶1，所述微波萃取功率为900瓦，微波萃取时间为4min；
3)将滤渣使用体积比为70％的乙醇水溶液浸提50min，过滤得到二次提取液；其中乙醇水溶液与滤渣的质量体积比为1∶5，浸提过程中的提取温度为80℃；
4)合并一次提取液和二次提取液得到粗提取液，将所述粗提取液通入离子交换树脂塔进行脱色处理，得到精提取液；其中，脱色时间为3.5h；
5)将精提取液减压浓缩原体积的1/7，超滤膜过滤后向其中加入冰片至浓度为0.1％，即可得到皮肤纾敏液。
实施例4
除原材料中的重量份数为：三七10份、地肤子20份、野菊花10份、丹参12份、金银花叶6份、虎杖根15份外，其他同实施例3。
实施例5
除原材料中的重量份数为：三七20份、地肤子10份、野菊花18份、丹参8份、金银花叶10份、虎杖根6份外，其他同实施例3。
实施例6-实施例10
除下述条件不同外，其他条件同实施例3。
表1实施例6-实施例10的皮肤纾敏液的提取条件
对比实施例1
按照CN 104721098 A实施例1所述的制备方法制备得到的皮肤纾敏液，其具体方法为：称取野菊全株15kg，野生常春藤茎/叶15kg，金缕梅茎/叶12kg，春黄菊花/ 叶15kg，金花茶叶6kg，落地生根茎/叶11kg，洗净、切碎，放入浸提锅中，加去离子水800kg，在搅拌下加热至80℃，保温搅拌浸提8小时，之后冷却至50℃以下过滤，除去植物残渣。滤液按每100kg加高岭土5kg的比例加入高岭土，搅拌60分钟，结束后静置陈化18小时，利用板框压滤机除去高土及其吸附的树胶、色素等杂质。滤液再用陶瓷超滤膜超滤一次，去除细小微粒，得澄清透明的复合提取液，即得。
对比实施例2
除未加入冰片外，其他同实施例3。
实施例11
将上述按照实施例1-实施例10制备得到的皮肤纾敏液以及对比实施例1和对比实施例2所述的产品用于下述过敏症状中，其中每种药液的每一症状的病例数为120 例，同一症状的各病例之间在过敏严重程度方面无显著性差异，其对于过敏性症状的改善率如下表所示。
表2本发明皮肤纾敏液对过敏症状的改善程度
由表2可以看出，本发明所述的皮肤纾敏液在治疗瘙痒、湿疹、红肿以及体液渗出方面均具有很好的效果，其与对比实施例1和对比实施例2相比具有显著性差异或极显著性差异，其中实施例3所制备的皮肤纾敏液的抗过敏效果最好，其处方最佳，制备条件最为合理。
Claims (6)
1.一种皮肤纾敏液的制备方法，其包括如下具体步骤：
1)称取三七10～20份、地肤子10～20份、野菊花10～18份、丹参8～12份、金银花叶6～10份、虎杖根6～15份，洗净后切片、干燥、粉碎，得到80目～120目干粉；
2)将干粉加纯化水溶解，然后采用微波萃取提取，过滤得到一次提取液，滤渣备用；其中，所述纯化水与所述干粉的质量比为7：1，所述微波萃取功率为900瓦，微波萃取时间为4min；
3)将滤渣使用体积比为70％的乙醇水溶液浸提40min～60min，过滤得到二次提取液；其中乙醇水溶液与滤渣的质量体积比为1:5，浸提过程中的提取温度为80℃；
4)合并一次提取液和二次提取液得到粗提取液，将所述粗提取液通入离子交换树脂塔进行脱色处理，得到精提取液；其中，脱色时间为2.5h～4h；
5)将精提取液减压浓缩原体积的1/7，超滤膜过滤后向其中加入冰片至其浓度为0.1％，即可得到皮肤纾敏液。
2.根据权利要求1所述的皮肤纾敏液的制备方法，其特征在于，皮肤纾敏液原材料的重量份数比为三七15份、地肤子15份、野菊花14份、丹参10份、金银花叶8份、虎杖根11份。
3.权利要求1或2所述的制备方法得到的皮肤纾敏液。
4.权利要求3所述的皮肤纾敏液在制备治疗或预防过敏的 化妆品中的应用。
5.根据权利要求4所述的应用，其特征在于，可制成液体喷雾剂直接喷洒于皮肤过敏部位，或制成乳液涂布于皮肤过敏部位。
6.根据权利要求4所述的应用，其特征在于，所述的过敏症状包括瘙痒、湿疹、红肿，体液渗出症状中的一种或多种。
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| CN105106277A (zh) * | 2015-08-10 | 2015-12-02 | 广州钤诺生物科技有限公司 | 一种抗敏、止痒复合植物提取物及其制备方法和应用 |
| CN105106384A (zh) * | 2015-08-25 | 2015-12-02 | 俞凤鸣 | 一种中药止痒洗剂 |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800131A (zh) * | 2015-05-13 | 2015-07-29 | 朱敏 | 一种美白抗过敏面膜液、制造方法及美白抗过敏面膜 |
| CN105106277A (zh) * | 2015-08-10 | 2015-12-02 | 广州钤诺生物科技有限公司 | 一种抗敏、止痒复合植物提取物及其制备方法和应用 |
| CN105106384A (zh) * | 2015-08-25 | 2015-12-02 | 俞凤鸣 | 一种中药止痒洗剂 |
Non-Patent Citations (1)
| Title |
|---|
| "金银花叶和花蕾提取物的抑菌活性研究";陈芳等人;《食品工程》;20130930(第3期);第36-38页 * |
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