CN105833351A - 具有优异生物活性的制备人工关节用材料 - Google Patents
具有优异生物活性的制备人工关节用材料 Download PDFInfo
- Publication number
- CN105833351A CN105833351A CN201610259319.5A CN201610259319A CN105833351A CN 105833351 A CN105833351 A CN 105833351A CN 201610259319 A CN201610259319 A CN 201610259319A CN 105833351 A CN105833351 A CN 105833351A
- Authority
- CN
- China
- Prior art keywords
- parts
- artificial joint
- silicone rubber
- joint material
- colloidal silica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 title claims abstract description 45
- 229920002379 silicone rubber Polymers 0.000 claims abstract description 24
- 239000004945 silicone rubber Substances 0.000 claims abstract description 24
- 102000008186 Collagen Human genes 0.000 claims abstract description 22
- 108010035532 Collagen Proteins 0.000 claims abstract description 22
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920002545 silicone oil Polymers 0.000 claims abstract description 22
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract description 21
- 239000000920 calcium hydroxide Substances 0.000 claims abstract description 21
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract description 21
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims abstract description 15
- 229920002554 vinyl polymer Polymers 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000008119 colloidal silica Substances 0.000 claims description 21
- 239000003517 fume Substances 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 10
- 239000000292 calcium oxide Substances 0.000 claims 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- -1 hydrogen Calcium oxide Chemical class 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract description 4
- 239000010936 titanium Substances 0.000 abstract description 4
- 229910052719 titanium Inorganic materials 0.000 abstract description 4
- 229920001436 collagen Polymers 0.000 abstract description 2
- 229910021485 fumed silica Inorganic materials 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 7
- 239000005977 Ethylene Substances 0.000 description 7
- 201000008482 osteoarthritis Diseases 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229910000531 Co alloy Inorganic materials 0.000 description 2
- 208000012659 Joint disease Diseases 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 208000008822 Ankylosis Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010023198 Joint ankylosis Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 210000001513 elbow Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 230000008407 joint function Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000001226 toe joint Anatomy 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/08—Carbon ; Graphite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610259319.5A CN105833351B (zh) | 2014-11-10 | 2014-11-10 | 具有优异生物活性的制备人工关节用材料 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610259319.5A CN105833351B (zh) | 2014-11-10 | 2014-11-10 | 具有优异生物活性的制备人工关节用材料 |
CN201410626137.8A CN104399129B (zh) | 2014-11-10 | 2014-11-10 | 一种制备人工关节用材料及其制备方法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410626137.8A Division CN104399129B (zh) | 2014-11-10 | 2014-11-10 | 一种制备人工关节用材料及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105833351A true CN105833351A (zh) | 2016-08-10 |
CN105833351B CN105833351B (zh) | 2019-03-22 |
Family
ID=52636834
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410626137.8A Active CN104399129B (zh) | 2014-11-10 | 2014-11-10 | 一种制备人工关节用材料及其制备方法 |
CN201610269088.6A Active CN105833352B (zh) | 2014-11-10 | 2014-11-10 | 具有优异生物相容性的制备人工关节用材料 |
CN201610259376.3A Active CN105833347B (zh) | 2014-11-10 | 2014-11-10 | 具有优异生物相容性的制备人工关节用材料及其制备方法 |
CN201610259319.5A Expired - Fee Related CN105833351B (zh) | 2014-11-10 | 2014-11-10 | 具有优异生物活性的制备人工关节用材料 |
CN201610259463.9A Expired - Fee Related CN105802232B (zh) | 2014-11-10 | 2014-11-10 | 一种制备人工关节用材料及其制备方法 |
CN201610262347.2A Active CN105854086B (zh) | 2014-11-10 | 2014-11-10 | 具有优异生物活性的制备人工关节用材料的制备方法 |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410626137.8A Active CN104399129B (zh) | 2014-11-10 | 2014-11-10 | 一种制备人工关节用材料及其制备方法 |
CN201610269088.6A Active CN105833352B (zh) | 2014-11-10 | 2014-11-10 | 具有优异生物相容性的制备人工关节用材料 |
CN201610259376.3A Active CN105833347B (zh) | 2014-11-10 | 2014-11-10 | 具有优异生物相容性的制备人工关节用材料及其制备方法 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
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CN201610259463.9A Expired - Fee Related CN105802232B (zh) | 2014-11-10 | 2014-11-10 | 一种制备人工关节用材料及其制备方法 |
CN201610262347.2A Active CN105854086B (zh) | 2014-11-10 | 2014-11-10 | 具有优异生物活性的制备人工关节用材料的制备方法 |
Country Status (1)
Country | Link |
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CN (6) | CN104399129B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107868303A (zh) * | 2017-11-21 | 2018-04-03 | 安徽北马科技有限公司 | 一种改性胶原蛋白‑橡胶复合材料的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS494559B1 (zh) * | 1970-08-06 | 1974-02-01 | ||
US4798606A (en) * | 1985-02-26 | 1989-01-17 | Corvita Corporation | Reinforcing structure for cardiovascular graft |
JP3801279B2 (ja) * | 1996-10-28 | 2006-07-26 | カトナジャパン株式会社 | パッド成形品 |
JP4247519B2 (ja) * | 1999-08-18 | 2009-04-02 | イントリンジック セラピューティックス インコーポレイテッド | 髄核オーグメンテーションおよび保定のための装置および方法 |
CN2565426Y (zh) * | 2002-09-05 | 2003-08-13 | 上海大学 | 一种人工关节 |
EP1989289B1 (en) * | 2006-02-07 | 2017-01-04 | Spinalcyte, LLC | Methods and compositions for repair of cartilage using an in vivo bioreactor |
CN101195045A (zh) * | 2006-12-07 | 2008-06-11 | 曾维桥 | 生物陶瓷和硅橡胶复合的生物医用材料 |
CN102363050A (zh) * | 2011-06-29 | 2012-02-29 | 大连林桥科技有限公司 | 一种医用生物材料及其制备方法 |
WO2013059780A1 (en) * | 2011-10-21 | 2013-04-25 | Nitta Casings Inc. | Collagen-polysaccharide materials mimicking blood vessels, tissues and bones for medical, pharmaceutical and orthopedic applications, and processes for producing the same |
CN102580583B (zh) * | 2012-03-30 | 2013-09-25 | 中蓝晨光化工研究设计院有限公司 | 一种硅橡胶超薄渗透膜的制备方法 |
CN103815989B (zh) * | 2012-11-19 | 2015-12-23 | 苏芳庆 | 拇指腕掌关节人工植体 |
CN103627175B (zh) * | 2013-12-11 | 2016-03-02 | 武汉大学 | 一种亲水型室温硫化硅橡胶 |
-
2014
- 2014-11-10 CN CN201410626137.8A patent/CN104399129B/zh active Active
- 2014-11-10 CN CN201610269088.6A patent/CN105833352B/zh active Active
- 2014-11-10 CN CN201610259376.3A patent/CN105833347B/zh active Active
- 2014-11-10 CN CN201610259319.5A patent/CN105833351B/zh not_active Expired - Fee Related
- 2014-11-10 CN CN201610259463.9A patent/CN105802232B/zh not_active Expired - Fee Related
- 2014-11-10 CN CN201610262347.2A patent/CN105854086B/zh active Active
Non-Patent Citations (3)
Title |
---|
石淑先: "《生物材料制备与加工》", 31 August 2009, 化学工业出版社 * |
聂恒凯: "《橡胶材料与配方》", 31 July 2004, 化学工业出版社 * |
谢英彪: "《欧美流行营养补充剂》", 30 September 2012, 江苏科学技术出版社 * |
Also Published As
Publication number | Publication date |
---|---|
CN105833352B (zh) | 2019-03-08 |
CN105833352A (zh) | 2016-08-10 |
CN105802232B (zh) | 2018-06-15 |
CN105833351B (zh) | 2019-03-22 |
CN105854086A (zh) | 2016-08-17 |
CN104399129B (zh) | 2016-08-24 |
CN105833347A (zh) | 2016-08-10 |
CN104399129A (zh) | 2015-03-11 |
CN105833347B (zh) | 2019-06-04 |
CN105802232A (zh) | 2016-07-27 |
CN105854086B (zh) | 2019-06-04 |
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Inventor after: Yang Xiujuan Inventor after: Zhu Xuelian Inventor after: Geng Zhihai Inventor after: Other inventor requests not to publish the name Inventor before: Request for anonymity |
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Effective date of registration: 20190228 Address after: 154002 No. 348 Dexiang Street, Jiamusi City, Heilongjiang Province Applicant after: THE FIRST AFFILIATED HOSPITAL OF JIAMUSI UNIVERSITY Address before: 213000 Jinling North Road, Xinbei District, Changzhou, Jiangsu, China, Hohai University Applicant before: Wu Jie |
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