CN105802232B - 一种制备人工关节用材料及其制备方法 - Google Patents

一种制备人工关节用材料及其制备方法 Download PDF

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CN105802232B
CN105802232B CN201610259463.9A CN201610259463A CN105802232B CN 105802232 B CN105802232 B CN 105802232B CN 201610259463 A CN201610259463 A CN 201610259463A CN 105802232 B CN105802232 B CN 105802232B
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李海燕
李延江
匡国芳
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Affiliated Hospital of University of Qingdao
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Abstract

本发明提供一种制备人工关节用材料及其制备方法，该材料包括按照质量份数计的如下原料：硅橡胶40~60份，胶原蛋白10~20份，乙烯基硅油1.5~4份，气相法白炭黑20~32份，氢氧化钙0.8~3份。本发明提供的材料具有优异的生物活性、生物相容性和骨传导性，均优于医用钛及硅橡胶，并且其强度高、机械性能好。

Description

一种制备人工关节用材料及其制备方法
技术领域
本发明涉及医学用品领域，尤其涉及一种制备人工关节用材料及其制备方法。
背景技术
人工关节是人们为挽救已失去功能的关节而设计的一种人工器官，它在人工器官中属于疗效最好的一种。一般来说，其使用年限可达20年以上。随着科技进步，人工关节手术已经是一种十分成功和有把握的手术：它可以即刻消除关节疼痛、恢复关节的正常活动功能，使长期受关节病痛折磨的人们再次获得新生，手术后可以像正常人那样，行走、爬楼、外出旅行、外出工作、购物和体育锻炼等。
人工关节的金属部件曾采用不锈钢来制做，后来又发展了钴合金材料，钴合金的耐腐蚀性、耐磨性和机械性能都较好。近来又发展了钛及钛合金材料，含钛材料不但耐腐蚀，而且比重小，更易与人自体的骨长在一起，是理想的材料。人工关节金属部件之间一般都垫有高密度超高分子量聚乙烯塑料。
多年来人们就采用各种人工关节治疗关节强直、关节畸形和各种破坏性骨关节疾病，力图将这些有病的关节矫正，并恢复功能，使之成为稳定的、不疼的，并有一定的功能的关节。为此许多学者做出了巨大的努力。迄今已研制出膝、髋、肘、肩、指、趾关节假体，用于临床。
我国每年20万例的人工关节置换手术。近20年来，我国关节疾病的发病人数不断攀升，其中老年性骨关节炎是发病最多的一种关节疾病。目前我国60岁以上老人中，有55%的人患有骨关节炎，全国约有1.2亿人患有此病。关节置换数量每年以超过30%的速度增加。我国有骨性关节炎的人数占总人口的3%、类风湿患者占0.3%、强直患者约占0.3%，这几千万人虽然不一定都要做手术，但需要做手术的人数最少是实施手术人数的10倍以上。也就是需要做人工关节的人数在200万以上，按每例人工关节材料费4-6万计算，市场理想需求在800亿以上，但是目前需要做手术并且实施手术的比例大约占10%-20%。也就是目前市场规模大约是80亿到160亿，随着生活提高和医改深入，医疗条件改善，目前我国人工关节置换手术增速是30%。
目前市场上现有的制备人工关节用材料本身脆度高、抗折强度低，并且不具有良好的生物活性和生物相容性。
发明内容
解决的技术问题：针对现有的制备人工关节用材料存在的缺点，本发明提供一种制备人工关节用材料及其制备方法，该材料具有优异的生物活性、生物相容性和骨传导性，并且其强度高、机械性能好。
技术方案：一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶40～60份，胶原蛋白10～20份，乙烯基硅油1.5～4份，气相法白炭黑20～32份，氢氧化钙0.8～3份。
上述所述的一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶45～55份，胶原蛋白12～18份，乙烯基硅油2～3份，气相法白炭黑24～30份，氢氧化钙1.3～2.3份。
上述所述的一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶48份，胶原蛋白14份，乙烯基硅油2.2份，气相法白炭黑25份，氢氧化钙1.5份。
上述所述的一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶50份，胶原蛋白15份，乙烯基硅油2.5份，气相法白炭黑27份，氢氧化钙1.8份。
上述所述的一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混10～20min，在温度为180～200℃下挤出，即得制备人工关节用材料。
上述所述的熔融共混15min，在温度为190℃下挤出。
有益效果：与现有技术相比，本发明提供的一种制备人工关节用材料及其制备方法，该材料具有优异的生物活性、生物相容性和骨传导性，均优于医用钛及硅橡胶，并且其强度高、机械性能好。
具体实施方式
实施例1
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶40份，胶原蛋白10份，乙烯基硅油1.5份，气相法白炭黑20份，氢氧化钙0.8份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混10min，在温度为180℃下挤出，即得制备人工关节用材料。
实施例2
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶60份，胶原蛋白20份，乙烯基硅油4份，气相法白炭黑32份，氢氧化钙3份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混20min，在温度为200℃下挤出，即得制备人工关节用材料。
实施例3
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶45份，胶原蛋白12份，乙烯基硅油2份，气相法白炭黑24份，氢氧化钙1.3份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混10min，在温度为180℃下挤出，即得制备人工关节用材料。
实施例4
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶55份，胶原蛋白18份，乙烯基硅油3份，气相法白炭黑30份，氢氧化钙2.3份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混20min，在温度为200℃下挤出，即得制备人工关节用材料。
实施例5
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶52份，胶原蛋白17份，乙烯基硅油2.8份，气相法白炭黑28份，氢氧化钙2份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混20min，在温度为200℃下挤出，即得制备人工关节用材料。
实施例6
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶48份，胶原蛋白14份，乙烯基硅油2.2份，气相法白炭黑25份，氢氧化钙1.5份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混15min，在温度为190℃下挤出，即得制备人工关节用材料。
实施例7
一种制备人工关节用材料，包括按照质量份数计的如下原料：硅橡胶50份，胶原蛋白15份，乙烯基硅油2.5份，气相法白炭黑27份，氢氧化钙1.8份。
一种制备人工关节用材料的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混15min，在温度为190℃下挤出，即得制备人工关节用材料。
性能测试
对本发明实施例1~7产品的性能进行测试，测试结果见表1。
表1产品性能测试数据
以上对本发明进行了详细介绍，对于本领域的一般技术人员，依据本发明实施例的思想，在具体实施方式及应用范围上均会有改变之处，综上所述，本说明书内容不应理解为对本发明的限制。

Claims (1)

1.一种制备人工关节用材料的制备方法，其特征在于，所述制备人工关节用材料包括按照质量份数计的如下原料：硅橡胶45～55份，胶原蛋白12～18份，乙烯基硅油2～3份，气相法白炭黑24～30份，氢氧化钙1.3～2.3份；
所述的制备方法，包括如下步骤：将硅橡胶、胶原蛋白、乙烯基硅油、气相法白炭黑和氢氧化钙加入挤出机中熔融共混10～20min，在温度为180～200℃下挤出，即得制备人工关节用材料。
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