CN105833179A - 治疗非酒精性脂肪性肝炎的中药 - Google Patents

治疗非酒精性脂肪性肝炎的中药 Download PDF

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CN105833179A
CN105833179A CN201610265194.7A CN201610265194A CN105833179A CN 105833179 A CN105833179 A CN 105833179A CN 201610265194 A CN201610265194 A CN 201610265194A CN 105833179 A CN105833179 A CN 105833179A
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魏侠
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Abstract

一种治疗非酒精性脂肪性肝炎的中药，各组分的质量份配比为：桑叶15‑25、荷叶蒂15‑25、当归15‑25、桂枝8‑25、薏米10‑25、炒麦芽10‑25、紫苏10‑15、柴胡10‑25、决明子15‑30、海藻12‑25、昆布12‑25、半夏3‑5、首乌15‑25、郁金8‑15、田基黄10‑15、丹参15‑25、绞股蓝18‑25、泽泻10‑15、黄精10‑24，山楂15‑20、枳壳15‑25、女贞子12‑25、枸杞12‑25、银杏叶12‑15。诸药合用对降血脂、改善肝功、改善肝脂肪代谢、降低血液粘稠度具良好作用疗效，无毒副作用。

Description

治疗非酒精性脂肪性肝炎的中药
技术领域
本发明涉及一种中药组合物，特别是一种治疗非酒精性脂肪性肝炎的中药组合物。
背景技术
临床流行病学研究表明，近年来随着人们生活习惯和饮食结构的改变，以及影像学的进步和广泛应用，脂肪肝的检出率日益增多，发病率不断升高。脂肪肝已成为仅次于病毒性肝炎的第二大肝病，已被公认为肝硬化的常见原因之一，非酒精性脂肪性肝炎起因多为过食肥甘厚味、过度肥胖或情志失调，或久病体虚。其发病机制为肝失疏泄，脾失健运，湿热内结，痰浊郁结，淤血阻滞，而最终形成痰湿淤阻互结，痹阻肝脏脉络而形成脂肪肝，病理基础与痰、瘀、湿、积有关，与肝、脾、肾三脏功能关系密切。目前西医治疗没有效药物，中医药治疗取得了一定的疗效。治以健脾祛湿，化痰消积，活血化瘀为主。
发明内容
本发明的目的在于提供一种治疗非酒精性脂肪性肝炎的中药，解决脂肪肝的治疗问题。
为实现上述目的，本发明采用的技术方案是：一种治疗非酒精性脂肪性肝炎的中药，其特征在于：各组分的质量份配比为：桑叶15-25、荷叶蒂15-25、当归15-25、桂枝8-25、薏米10-25、炒麦芽10-25、紫苏10-15、柴胡10-25、决明子15-30、海藻12-25、昆布12-25、半夏3-5、首乌15-25、郁金8-15、田基黄10-15、丹参15-25、绞股蓝18-25、泽泻10-15、黄精10-24，山楂15-20、枳壳15-25、女贞子12-25、枸杞12-25、银杏叶12-15。
上述的一种治疗非酒精性脂肪性肝炎的中药，其特征在于：各组分的重量份配比为：桑叶25、荷叶蒂25、薏米25、当归25、桂枝15、炒麦芽25、紫苏15、柴胡20、决明子30、海藻25、昆布20、半夏3、首乌25、郁金15、田基黄15、丹参25、绞股蓝25、泽泻15、黄精24、山楂18、枳壳25、女贞子12、枸杞25、银杏叶15。
本发明所述的治疗非酒精性脂肪性肝炎的中药，可制成汤剂，制作方法为：将各原料清洗干净，用冷水下药，浸泡10分钟后上火，武火至沸后用中火煮20分钟，煎煮两遍将汤剂混合，分早晚两次温服。连续服用15-20天，下月开始第二疗程。也可制成膏剂、浓缩片、丸剂，以上各成分也可制成超细状态的药粉状，做成胶囊，连续服用。
本发明的优点在于，方中桑叶、紫苏、柴胡、黄精、女贞子滋补肝肾、疏肝养肝解郁；银杏叶、当归、桂枝、丹参、首乌、郁金行气、活血养血、补益精血；炒麦芽、山楂、枳壳消食化积，理气健脾、化湿和胃；薏米、决明子、海藻、昆布、半夏、泽泻利水消肿，渗湿，泄热，降血脂、改善肝功、改善肝脂肪代谢，有抗脂肪肝作用；银杏叶、绞股蓝、田基黄益气健脾，化痰止咳，清热解毒；银杏叶、绞股蓝、黄精、枸杞以扶正健脾益肾，提高机体免疫力。诸药合用对降血脂、改善肝功、改善肝脂肪代谢、降低血液粘稠度具良好作用疗效，无毒副作用。
下面对本发明中使用的各种中药药用性能进行简要介绍
桑叶：疏散风热，清肺润燥，平抑肝阳，清肝明目。
荷叶蒂：固精止带，补脾止泻，益肾养心，降血脂。
海藻：消痰软坚，利水消肿。褐藻酸硫酸酯有抗高血脂症作用。
昆布：消痰软坚，利水消肿。
桂枝：发汗解肌，温通经脉，助阳化气，既可温扶脾阳以助运水，又可温肾阳、逐寒邪以助膀胱气化，而行水湿痰饮之邪，为治疗痰饮病、蓄水证的常用药。
紫苏：解表散寒，行气宽中，能行气以宽中除胀，和胃止呕。
柴胡：具有镇静、安定、镇痛、解热、镇咳等广泛的中枢抑制作用。柴胡及其有效成分柴胡皂苷有抗炎作用，其抗炎作用与促进肾上腺皮质系统功能等有关。柴胡皂苷又有降低血浆胆固醇作用。柴胡有较好的抗脂肪肝、抗肝损伤、利胆、降转氨酶、兴奋肠平滑肌、抑制胃酸分泌、抗溃疡、抑制胰蛋白酶等作用。柴胡煎剂对结核杆菌有抑制作用。
决明子：渗湿，健脾。本品有降低血浆总胆固醇和甘油三脂的作用；其注射液可使小鼠胸腺萎缩，对吞噬细胞吞噬功能有增强作用；其所含蒽醌类物质有缓和的泻下作用；其醇浸出液除去醇后，对金黄色葡萄球菌、白色葡萄球菌、桔色葡萄球菌、白喉杆菌、巨大芽孢杆菌、伤寒杆菌、副伤寒杆菌、乙型副伤寒杆菌及大肠杆菌均有抑制作用；其水浸液对皮肤真菌有不同程度的抑制作用。
薏米：利水消肿，渗湿，健脾，除痹，清热排脓，薏苡仁煎剂、醇及丙酮提取物对癌细胞有明显抑制作用。薏苡仁内酯对小肠有抑制作用。其脂肪油能使血清钙、血糖量下降，并有解热、镇静、镇痛作用。
泽泻：利水消肿，渗湿，泄热。对肾炎患者有利尿作用，能增加尿量，增加尿素与氯化物的排泄，利尿作用更为明显。有降压、降血糖作用，还有抗脂肪肝作用。对金黄色葡萄球菌、肺炎双球菌、结核杆菌有抑制作用。
田基黄：利湿退黄，清热解毒，活血消肿。
枳壳：破气除痞，化痰消积。主治胃肠积滞，湿热泻痢，胸痹，结胸，气滞胸肋疼痛，产后酸痛。
麦芽：消食健胃，回乳消胀。本品又兼能疏肝解郁，常配川楝子、柴胡等，用治肝气郁滞或肝胃不和之胁痛、脘腹痛等。
山楂：消食化积，行气散瘀。主治：积食积滞，泻痢腹痛，疝气痛，瘀阻胸腹痛，痛经。
黄精：补气养阴，健脾，润肺，益肾。黄精能提高机体免疫功能和促进DNA、RNA及蛋白质的合成，促进淋巴细胞转化作用；有增加冠脉流量及降压作用，并能降血脂及减轻冠状动脉粥样硬化程度。
枸杞：滋补肝肾，益精明目。具有免疫调节作用；可提高血睾酮水平，起强壮作用；对造血功能有促进作用；对正常健康人也有显著升白细胞，还有抗衰老、抗突变、抗肿瘤、降血脂、保肝及抗脂肪肝、降血糖、降血压作用。
首乌：补益精血。首乌能使其血中的高胆固醇较快下降至正常水平。首乌中提出的大黄酚能促进肠管运动。
当归：补血调经，活血止痛，润肠通便。
丹参：活血调经，祛瘀止痛，凉血消痈，除烦安神。现代研究能扩张冠脉，增加冠脉血流量，改善心肌缺血，促进心肌缺血或损伤的恢复，缩小心肌梗死范围；能提高耐缺氧能力，对缺氧心肌有保护作用；能改善微循环，促进血液流速；能扩张血管，降低血压。能改善血液流变性，降低血液粘度，抑制血小板和凝血功能，激活纤溶，对抗血栓形成；能保护红细胞膜。能调节血脂，抑制动脉粥样硬化斑块的形成。能保护肝细胞损伤，促进肝细胞再生，有抗肝纤维化作用。能促进骨折和皮肤切口的愈合。能保护胃粘膜、抗胃溃疡。
半夏：燥湿化痰，降逆止呕，消痞散结；外用消肿止痛。
绞股蓝：益气健脾，化痰止咳，清热解毒。绞股蓝及绞股蓝皂苷均具有抗疲劳、抗缺氧、抗高温、抗低温，延长生物体细胞及果蝇、小鼠的寿命，能明显升高SOD活性，降低心、脑、肝细胞内脂褐素的含量，防止正常细胞癌化，提高荷瘤动物免疫力；能明显增加非特异性免疫、细胞免疫、体液免疫的功能，且具免疫调节作用；具有明显的清除氧自由基及抑制或减轻肝细胞变性、坏死及炎症反应；促进肝细胞再生，并有抗肝纤维化的作用，降血脂、降血糖作用，并能提高脾脏、睾丸、大脑和血液蛋白质的合成速率，并具有镇静、催眠、镇痛、增加冠脉流量、抗心肌缺血、增加脑血流量、抑制血栓形成、保肝、抗溃疡等作用。
银杏叶：功能敛肺平喘，活血止痛。用于肺虚咳喘，以及高血脂、高血压、冠心病心绞痛、脑血管痉挛等。
女贞子：滋补肝肾，乌须明目。
郁金：行气化淤、清心解郁、利胆退黄。
方中桑叶、紫苏、柴胡、黄精、女贞子滋补肝肾、疏肝养肝解郁；银杏叶、当归、桂枝、丹参、首乌、郁金行气、活血养血、补益精血；炒麦芽、山楂、枳壳消食化积，理气健脾、化湿和胃；薏米、决明子、海藻、昆布、半夏、泽泻利水消肿，渗湿，泄热，降血脂、改善肝功、改善肝脂肪代谢，有抗脂肪肝作用；银杏叶、绞股蓝、田基黄益气健脾，化痰止咳，清热解毒；银杏叶、绞股蓝、黄精、枸杞以扶正健脾益肾，提高机体免疫力。诸药合用具有清除氧自由基及抑制或减轻肝细胞变性、坏死及炎症反应；促进肝细胞再生，并有抗肝纤维化的作用。具有降血脂、改善肝功、改善肝脂肪代谢、降低血液粘稠度的疗效。
经临床258人次使用，其中男250人，女8人，年龄28-58岁，病程1-10年，总有效率98.8％，与服用他汀类药物降血脂相比，患者的临床症状、体征消失、肝功能、血脂、血糖及B超各指标明显改善以及总的临床疗效显著，效果明显，无毒副作用。
表1两组治疗后综合疗效对比
组别(例) 治愈 显效 好转 无效 总有效率
研究组(258) 125 122 8 3 98.8％
对照组(200) 21 67 58 54 66.5％
与对照组治疗后结果对比：P＜0.05。
具体实施方式
实施例1：
一种治疗非酒精性脂肪性肝炎的中药，各组分的重量份配比为：桑叶15g、荷叶蒂20g、薏米20g、当归25g、桂枝10g、炒麦芽25g、紫苏15g、柴胡20g，决明子30g、海藻24g、昆布20g、半夏3g、首乌25g、郁金15g、田基黄15g、丹参25g、绞股蓝23g、泽泻15g、黄精24g、山楂18g、枳壳15g、女贞子12g、枸杞15g、银杏叶15g。制成汤剂。
用法：将各原料清洗干净，用冷水下药，浸泡10分钟后上火，武火至沸后用中火煮20分钟，煎煮两遍将汤剂混合，分早晚两次温服。
实施例2：
一种治疗非酒精性脂肪性肝炎的中药，各组分的重量份配比为：桑叶20g、荷叶蒂24g、薏米25g、当归20g、桂枝15g、炒麦芽20g、紫苏12g、柴胡18g、决明子28g、海藻15g、昆布20g、半夏4g、首乌25g、郁金10g、田基黄12g、丹参25g、绞股蓝20g、泽泻12g、黄精24g、山楂15g、枳壳20g、女贞子12g、枸杞12g、银杏叶15g。制成汤剂。
用法：将各原料清洗干净，用冷水下药，浸泡10分钟后上火，武火至沸后用中火煮20分钟，煎煮两遍将汤剂混合，分早晚两次温服。
病例应用：
田某，男，28岁，脂肪性肝炎，肥胖，自觉稍疲乏，平时活动量小，血糖稍高，经用本发明的产品3个月后，好转，B超检查后诊断为肝内仅仅脂肪沉积，血糖正常范围。
实施例3(最佳实施例)
一种治疗非酒精性脂肪性肝炎的中药，各组分的重量份配比为：桑叶25g、荷叶蒂25g、薏米25g、当归25g、桂枝15g、炒麦芽25g、紫苏15g、柴胡20g、决明子30g、海藻25g、昆布20g、半夏3g、首乌25g、郁金15g、田基黄15g、丹参25g、绞股蓝25g、泽泻15g、黄精24g、山楂18g、枳壳25g、女贞子12g、枸杞25g、银杏叶15g。
用法：将各原料清洗干净，用冷水下药，浸泡10分钟后上火，武火至沸后用中火煮20分钟，煎煮两遍将汤剂混合，分早晚两次温服。
病例应用：
高某，男，46岁，脂肪性肝炎，肥胖，自觉疲乏无力，嗜睡、无精神偶感，头痛头晕、头部稍脱发，腹泻、没有一点食欲，B超检查后诊断为脂肪性肝炎，开具上述中药水煎服，每天一剂，连服20天，停10天，开始下一疗程，连服3个月治愈。

Claims (2)

1.一种治疗非酒精性脂肪性肝炎的中药，其特征在于：各组分的质量份配比为：桑叶15-25、荷叶蒂15-25、当归15-25、桂枝8-25、薏米10-25、炒麦芽10-25、紫苏10-15、柴胡10-25、决明子15-30、海藻12-25、昆布12-25、半夏3-5、首乌15-25、郁金8-15、田基黄10-15、丹参15-25、绞股蓝18-25、泽泻10-15、黄精10-24、山楂15-20、枳壳15-25、女贞子12-25、枸杞12-25、银杏叶12-15。
2.根据权利要求1所述的一种治疗非酒精性脂肪性肝炎的中药，其特征在于：各组分的重量份配比为：桑叶25、荷叶蒂25、薏米25、当归25、桂枝15、炒麦芽25、紫苏15、柴胡20、决明子30、海藻25、昆布20，半夏3、首乌25、郁金15、田基黄15、丹参25、绞股蓝25、泽泻15、黄精24、山楂18、枳壳25、女贞子12、枸杞25、银杏叶15。
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CN106109767A (zh) * 2016-07-13 2016-11-16 郑亮 一种防治非酒精性脂肪性肝病的复方制剂
CN109925469A (zh) * 2017-12-18 2019-06-25 上海市中医医院 一种治疗肝郁脾虚型非酒精性脂肪肝的中药组合物及应用
CN114558099A (zh) * 2022-03-29 2022-05-31 沈阳市第六人民医院 中药组合物及其制备方法和应用

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CN103330865A (zh) * 2013-07-23 2013-10-02 邵阳县中医医院 一种治疗非酒精性脂肪性肝炎的药物及制备方法

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CN102106992A (zh) * 2011-01-30 2011-06-29 河南中医学院 一种治疗非酒精性脂肪性肝炎的中药颗粒
CN103330865A (zh) * 2013-07-23 2013-10-02 邵阳县中医医院 一种治疗非酒精性脂肪性肝炎的药物及制备方法

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Publication number Priority date Publication date Assignee Title
CN106109767A (zh) * 2016-07-13 2016-11-16 郑亮 一种防治非酒精性脂肪性肝病的复方制剂
CN109925469A (zh) * 2017-12-18 2019-06-25 上海市中医医院 一种治疗肝郁脾虚型非酒精性脂肪肝的中药组合物及应用
CN109925469B (zh) * 2017-12-18 2021-07-30 上海市中医医院 一种治疗肝郁脾虚型非酒精性脂肪肝的中药组合物及应用
CN114558099A (zh) * 2022-03-29 2022-05-31 沈阳市第六人民医院 中药组合物及其制备方法和应用

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