CN105832765A - External liquid medicine for preventing and treating beriberi and preparation method thereof - Google Patents
External liquid medicine for preventing and treating beriberi and preparation method thereof Download PDFInfo
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- CN105832765A CN105832765A CN201610313187.XA CN201610313187A CN105832765A CN 105832765 A CN105832765 A CN 105832765A CN 201610313187 A CN201610313187 A CN 201610313187A CN 105832765 A CN105832765 A CN 105832765A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an external liquid medicine for preventing and treating beriberi and a preparation method thereof. The liquid medicine is prepared from, by mass, 36-68 parts of alcohol, 13-45 parts of distilled water, 2-4 parts of zinc acetate, 3-5 parts of benzoic acid, 4-6 parts of salicylic acid, 1-3 parts of tannic acid, 2-4 parts of boric acid and 1-2 parts of essence. The external liquid medicine is prepared through the process steps of preparation, purification and filling. The external liquid medicine has the effects of preventing and treating beriberi, foot sweat and foot odors, it is shown through the clinical test statistical result that the total effective rate is 97.5%, and the external liquid medicine belongs to safe external medicine and can be used as a spray or used for smearing prevention and treatment.
Description
Technical field
The invention belongs to the healing potion research and development technology field of tinea pedis, relate to a kind of external preventing and treating tinea pedis
Medicinal liquid and preparation method thereof.
Background technology
Along with improving constantly of people's living standard, pursue high-grade life style and come into fashion, foot
Gas, sweaty foot, foot odor are the common skin diseases caused by fungal infection, general summer sickness rate
Height, winter, sickness rate was low, easily recurred, and groups of people are not healed, and it annoyings the productive life of people.
Summary of the invention
The present invention is to solve the problems referred to above, devise a kind of external medicinal liquid preventing and treating tinea pedis and preparation thereof
Method, it is possible to effectively prevent and treat tinea pedis, sweaty foot, foot odor problem.
The technical solution used in the present invention is: a kind of external medicinal liquid preventing and treating tinea pedis, it is critical only that: should
Medicinal liquid includes the raw material of following mass fraction ratio:
Preferably, this medicinal liquid includes the raw material of following mass fraction ratio: ethanol 49 parts, distilled water 33
Part, zinc acetate 2 parts, 5 parts of benzoic acid, salicylic acid 5 parts, tannic acid 3 parts, boric acid 2 parts, essence 1
Part.
As above the preparation method of external medicinal liquid, this preparation method comprises the steps:
A. preparation: weigh each raw material than relation by mass fraction, falls according to the order of solid after first liquid
Enter in the acid-resistant container got ready and be stirred so that it is fully dissolve each other；
B. purify: under room temperature, deposit 3-5 days, filter off impurity, be semi-finished product material；
C. fill: utilize filling machine to be loaded by semi-finished product material in quantitative bottle, mouth is closed and seals, add
Outer package is product.
The beneficial effects of the present invention is: zinc acetate [(CH3COO)2Zn] there is the effect preventing and treating sweaty foot, its
Aqueous solution is a kind of excellent organic solvent；Benzoic acid (benzoic acid) acts primarily as suppression fungus and grows
With drive smelly effect；Salicylic acid (salicylic acid) acts primarily as slough effect；Tannic acid (tannic acid) rises to be received
Hold back the effect of wound；Boric acid plays sterilization detumescence effect；Ethanol, distilled water mainly make solvent and use；Essence
Sense organ aroma effect can be improved.Owing to adding appropriate zinc acetate, substantially increase benzoic acid, bigcatkin willow
The organic acid dissolubility such as acid, enhance the stability of medicinal liquid, improve the medicine usefulness of said composition,
Antibacterial, sterilize, control tinea pedis, go antiperspirant, deodorizing effect to become apparent from.Clinical trial statistical result showed,
Total effective rate is 97.5%.
Detailed description of the invention
Embodiment one: prevent and treat tinea pedis
A kind of external medicinal liquid preventing and treating tinea pedis, can select by the raw material group of following mass fraction ratio
Become: ethanol 49 distilled water 33 zinc acetate 2 benzoic acid 5 salicylic acid 5 tannic acid
3 boric acid 2 essence 1
Following processing step is taked to produce:
A. preparation: weighed up by the raw material of above mass fraction ratio, falls according to the order of solid after first liquid
Enter in the acid-resistant container got ready and be stirred so that it is fully dissolve each other；
B. purify: under room temperature, deposit 3-5 days, filter off impurity, be semi-finished product material.
C. fill: utilize filling machine to be loaded by semi-finished product material in quantitative bottle, mouth is closed and seals, add
Outer package is product.
Embodiment two: preventing and treating sweaty foot
A kind of external medicinal liquid preventing and treating tinea pedis, can select by the raw material group of following mass fraction ratio
Become: ethanol 68 distilled water 15 zinc acetate 4 benzoic acid 3 salicylic acid 4 tannic acid 1
Boric acid 4 essence 1
Following processing step is taked to produce:
A. preparation: weighed up by the raw material of above mass fraction ratio, falls according to the order of solid after first liquid
Enter in the acid-resistant container got ready and be stirred so that it is fully dissolve each other；
B. purify: under room temperature, deposit 3-5 days, filter off impurity, be semi-finished product material.
C. fill: utilize filling machine to be loaded by semi-finished product material in quantitative bottle, mouth is closed and seals, add
Outer package is product.
Embodiment three: anti-treating bad smell of feet
A kind of external medicinal liquid preventing and treating tinea pedis, can select by the raw material group of following mass fraction ratio
Become: ethanol 36 distilled water 46 zinc acetate 2 benzoic acid 5 salicylic acid 4 tannic acid
1 boric acid 4 essence 2
Following processing step is taked to produce:
A. preparation: weighed up by the raw material of above mass fraction ratio, falls according to the order of solid after first liquid
Enter in the acid-resistant container got ready and be stirred so that it is fully dissolve each other；
B. purify: under room temperature, deposit 3-5 days, filter off impurity, be semi-finished product material.
C. fill: utilize filling machine to be loaded by semi-finished product material in quantitative bottle, mouth is closed and seals, add
Outer package is product.
Clinical trial
Test medicine: " happy outstanding person's board bacteriostasis spray " a kind of external medicinal liquid institute in clinic preventing and treating tinea pedis
The title used, specification 30ml/ bottle, lot number 150915, glass bottle packaging (during use, takes this agent pair
The spraying of quasi-tinea pedis affected part is several lower, uses 1-2 time general every day, it is also possible to alignment foot or footgear spray
Spill, reach sweaty foot, effect except foot odor).
From JIUYUE in 2015 in March, 2016, we utilize the time of half a year, by clinical
600 example patients (male 432 examples, female 168 example, age 12-81 year) prevention effect analysis, cure 392
Example；Take a turn for the better 193 examples；Invalid only account for 15 examples；Total effective rate reaches 97.5%.(efficacy assessment standard and
The results are shown in Table 1, table 2):
Table 1 efficacy assessment standard
Table 2 clinical curative effect analysis
Clinical patients test statistics result shows, this medicine prevent and treat tinea pedis, sweaty foot, foot odor effect certain
Very well.
Cutaneous safety is tested
Test medicine: " happy outstanding person's board bacteriostasis spray " a kind of external medicinal liquid institute in an experiment preventing and treating tinea pedis
The title (hereinafter referred to as " medicinal liquid ") used, specification 30ml/ bottle, lot number 150915, vial bag
Dress.
1, toxicity test: this test select rabbit as experimental animal, observe 3 times on the one complete rabbit
Give with toxic reaction produced after medicinal liquid on whole and damaged depilation skin.Take healthy rabbits 8,
24h before test, by every family's rabbit back both sides first with curved scissors unhairing about 150cm2, then with 8% sodium sulfide
Solution loses hair or feathers.It is randomly divided into 2 groups (often groups 4), i.e. intact skin group and damaged skin group.Depilation
After 24h, weigh rabbit body weight and record (original body mass).Rabbit is fixed in fixed mount, complete skin
Medicinal liquid is only embrocated on depilation epidermis by skin group rabbit by 6ml/, and with non-stimulated gauze, immobilization with adhesive tape；
Damaged skin group rabbit depilation epidermis first uses 75% ethanol disinfection, then with the network-like cut of aseptic syringe needle row,
It is degree to oozing of blood, embrocates on cut oozing of blood depilation epidermis by 6ml/ medicinal liquid immediately, and with non-stimulated
Sha Bu, immobilization with adhesive tape.Sending two groups of rabbit back to respective cage position after administration, affranchise feed and drinking-water.
Embrocated every 4 hours 1 time, embrocate 3 times continuously.Medicinal liquid is washed away with warm water after 24 hours, in order to
Observe.Observe and record administration 1,24,48,72 hours and 4,5,6,7 days rabbit skins, hairs
Send out, the situation of eyes, mucosa, body weight, and breathings, circulation, central nervous system, extremity work
The dynamic change waited.Intact skin group and 3 medications on the one of damaged skin group rabbit, Continuous Observation 7 days,
Damaged skin is i.e. spontaneous recovery after 24 hours；Two groups of rabbit depilation skins are showed no skin erythema, edema, hair
Send out, eyes, mucosa and breathing, circulation, central nervous system, extremity activity the most normal.Result
Show: after every rabbit intact skin and damaged skin embrocate medicinal liquid, do not produce toxic reaction, be shown in Table 3,
Table 4: acute toxicity test record.
2, sensitivity test: in vitro selection Cavia porcellus, as experimental animal, connects by making guinea pig skin repeat
After touching medicinal liquid, observe body immune system reaction performance on skin.Select albino guinea-pig 30,
Body weight 250～300g, male and female half and half, guinea pig back diamond wool was taken off in first 24 hours in being administered, de-
The every side of hair-fields scope about 3 × 3cm2.1-CHLORO-2,4-DINITROBENZENE acetone is selected to make the sensitization solution of 1%
With 0.1% the concentration that excites be positive sensitizer.Cavia porcellus is randomly divided into 3 groups by body weight, sex, often
Organize 10 (male and female half and half).First group to tested material medicinal liquid；Second group of blank (solvent: 50% second
Alcohol)；3rd group of positive thing comparison (giving positive sensitizer).Carrying out sensitization contact, taking liquid 0.2ml is coated with
On the left of Cavia porcellus, depilation district, is fixed with nonirritant gauze, adhesive plaster, continues 6 hours, with temperature
Medicinal liquid is removed in washing.7th day and the 14th day, it is repeated once in the same way.Blank group and sun
Property thing matched group method is ibid.Carry out exciting contact, after last is to medicinal liquid sensitization 14 days, by medicinal liquid
0.2ml is applied to depilation district on the right side of guinea pig back, and with gauze, immobilization with adhesive tape, washes with warm water after 6 hours
Remove medicinal liquid, at once observe, then again observe skin allergy situation in 24,48,72 hours,
(table 5--skin allergy standards of grading) are marked by table 5.Blank group and the positive thing side of comparison
Method is all with test medicine group.After 3 sensitization contact, slight erythema seen from positive thing matched group, after 3 days
Disappear；Administration group and blank group are showed no erythema；After exciting contact, positive thing matched group is visible
Edematous erythema, the most visible after 72 hours；Administration group and blank group have no erythema and edema.Examination
Test result by dermoreaction standards of grading mark after, react according to test group and matched group guinea pig skin
By table 5, difference, judges that medicinal liquid (sees attached list 7--medicinal liquid skin allergy anti-to skin allergy character
Should evaluate).Sensitization rate is judged by the classification of subordinate list 6 (seeing attached list 6--skin irritation intensity evaluation).
The calculating of sensitization rate is that the animal number of cases that will appear from skin erythema or edema (no matter degree weight) is divided by being subject to
Examination animal number.Result shows: medicinal liquid has no and causes obvious skin allergy.
3, irritation test: this test selects rabbit as experimental animal, observes at rabbit intact skin
And produced irritant reaction after embrocating medicinal liquid on damaged skin.Take healthy rabbits 6, the front 24h of test,
By every family's rabbit back both sides first with curved scissors unhairing about 150cm2, then lose hair or feathers with 8% sodium sulfide solution, with
Machine is divided into 2 groups (often groups 3), i.e. intact skin group and damaged skin group, after depilation 24h, weighs
Rabbit body weight record.Being fixed in fixed mount by rabbit before Gei Yaoing, intact skin group is by medicinal liquid 1ml
Embrocate on left side depilation epidermis, natural airing；0.9% sodium chloride solution is embrocated in depilation district, right side, does
Blank.Damaged skin group rabbit depilation epidermis first uses 75% ethanol disinfection, then with aseptic syringe needle row net
Network shape cut, is degree to oozing of blood, embrocates medicinal liquid 1ml immediately and loses hair or feathers on epidermis in left side cut oozing of blood,
Natural airing；Right side cut oozing of blood depilation epidermis embrocates 0.9% sodium chloride solution, does blank.With
After non-stimulated husky cloth, immobilization with adhesive tape, rabbit being sent respective cage position back to, affranchise feed and drinking-water.
After 24 hours, wash away residual test medicine with warm water and observe.After observing and record removal tested material
1, the phenomenon such as 24,48,72 hours rabbit skin erythemaes, edema and the recovery situation of these changes and
Time.It was found that after intact skin group and 1 medication on the one of damaged skin group rabbit, be showed no
The phenomenon such as skin erythema, edema, spontaneous recovery after damaged skin 24h, every rabbit result of the test presses skin
Irritant reaction is marked, and erythema and edema score value are 0；Skin irritation intensity score value ＜ 0.5.Show medicine
Liquid is to no skin irritation (see irritation test table 8, table 9).
The present invention passes through above three safety experiments, shows that this medicinal liquid belongs to safe external used medicine.
Table 3
Table 4
The same day body weight: X ± SD 2.30 ± 0.11；7 daily weights: X ± SD 2.39 ± 0.14.
Table 5 skin allergy standards of grading
Table 6 sensitization rate is classified
Table 7 skin allergy evaluation
Table 8 skin wound repair is marked
| Irritant reaction | Score value | Irritant reaction | Score value |
| Erythema: | Edema: | ||
| Without erythema | 0 | Without edema | 0 |
| The most visible | 1 | The most visible | 1 |
| Moderate erythema | 2 | Cutaneous protuberance profile understands | 2 |
| Severe erythema | 3 | Edema swells about 1mm expanded range | 4 |
| Aubergine erythema also has eschar to be formed | 4 | Total score | 8 |
Table 9 skin irritation intensity evaluation
| Intensity | Score value | Intensity | Score value |
| Nonirritant | ＜ 0.5 | Moderate zest | ＜ 6.0 |
| Slight zest | ＜ 3.0 | Intensity zest | ＞ 6.0 |
Claims (3)
1. the external medicinal liquid preventing and treating tinea pedis, it is characterised in that: this medicinal liquid includes following mass parts
The raw material of number ratio:
A kind of external medicinal liquid preventing and treating tinea pedis the most according to claim 1, it is characterised in that: should
Medicinal liquid includes the raw material of following mass fraction ratio: ethanol 49 parts, distilled water 33 parts, zinc acetate 2
Part, 5 parts of benzoic acid, salicylic acid 5 parts, tannic acid 3 parts, boric acid 2 parts, 1 part of essence.
3. prevent and treat a preparation method for the external medicinal liquid of tinea pedis, its feature as claimed in claim 1
It is: this preparation method comprises the steps:
A. preparation: weigh each raw material than relation by mass fraction, falls according to the order of solid after first liquid
Enter in the acid-resistant container got ready and be stirred so that it is fully dissolve each other；
B. purify: under room temperature, deposit 3-5 days, filter off impurity, be semi-finished product material；
C. fill: utilize filling machine to be loaded by semi-finished product material in quantitative bottle, mouth is closed and seals, add
Outer package is product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610313187.XA CN105832765A (en) | 2016-05-12 | 2016-05-12 | External liquid medicine for preventing and treating beriberi and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610313187.XA CN105832765A (en) | 2016-05-12 | 2016-05-12 | External liquid medicine for preventing and treating beriberi and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105832765A true CN105832765A (en) | 2016-08-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610313187.XA Pending CN105832765A (en) | 2016-05-12 | 2016-05-12 | External liquid medicine for preventing and treating beriberi and preparation method thereof |
Country Status (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113813285A (en) * | 2021-10-23 | 2021-12-21 | 闫颖 | Foot care targeting foot soaking liquid for removing beriberi |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843637A (en) * | 2010-05-17 | 2010-09-29 | 段怀锁 | External spray for preventing and treating beriberi and preparation method |
| CN101972270A (en) * | 2010-11-09 | 2011-02-16 | 石家庄乐足科技有限公司 | External powder for preventing and curing dermatophytosis |
-
2016
- 2016-05-12 CN CN201610313187.XA patent/CN105832765A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843637A (en) * | 2010-05-17 | 2010-09-29 | 段怀锁 | External spray for preventing and treating beriberi and preparation method |
| CN101972270A (en) * | 2010-11-09 | 2011-02-16 | 石家庄乐足科技有限公司 | External powder for preventing and curing dermatophytosis |
Non-Patent Citations (1)
| Title |
|---|
| 迟锡增: "《微量元素与人体健康》", 31 March 1997 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113813285A (en) * | 2021-10-23 | 2021-12-21 | 闫颖 | Foot care targeting foot soaking liquid for removing beriberi |
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