CN104623252B - A kind of compound fenticonazole nitrate preparation and its application - Google Patents
A kind of compound fenticonazole nitrate preparation and its application Download PDFInfo
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Abstract
The present invention relates to a kind of compound fenticonazole nitrate preparation and application, for traditional Chinese and western medicine compound preparation, it is prepared by following raw materials, fenticonazole nitrate 10g, effective component of chinese medicine 10g, poloxamer188 30g, PLURONICS F87 15g, carbomer 5g, propane diols 250g, glycerine 150g, sodium benzoate 5g, disodium ethylene diamine tetraacetate 0.3g, distilled water 475g.The present invention compound medicine vaginitis is treated both principal and secondary aspect of disease, it is nontoxic to human body, have no side effect, it is cheap, it is simple for production, have broad application prospects.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of compound fenticonazole nitrate preparation and its application.
Background technology
Vaginitis is a kind of using the change of leukorrhea character, pruritus vulvue, vulva cusalgia, intercourse pain as main clinical manifestation, female
Property common diseases associated with inflammation, can be with bladder irritation frequent micturition, urgent urination, odynuria, severe patient may occur in which a small amount of bleeding of vagina, disease
Journey elder can occur together anaemia, headache, the weary powerless, insomnia of dizzy, body occur and the symptom such as easily wake up, be the one kind for perplexing women's health
Gynaecology's common disease.For dissection is upper, the vulva of women is in the state of a Natural closure, and vaginal wall is in usually front and rear wall
It is also the state of closure, mediate contact infection is a route of transmission of colpomycosis.What contact was infected by mould patient
Toilet seat, bathtub, bathing pool seat, the towel of lavatory, using unclean toilet paper, can cause to propagate, when outside infected person altogether
When the candida albicans of vagina reaches certain amount, you can occur mycotic vulvovaginitis.
At present, doctor trained in Western medicine for vaginitis treatment more than it is antimycotic using part and/or whole body application antibiotic and/or azole
Medicine, fenticonazole nitrate is common drug,
Fenticonazole nitrate
English language Chemical name: 1-[2-(2,4-dichlorophenyl)-2-[[4-(phenylthio)phenyl]
methoxy] ethyl- 1H-imidazole mononitrate
Chinese chemical name:1- [2- (2,4 dichloro benzene base) -2- [[4- (benzene is thio) phenyl] methoxyl group] ethyl -1H- miaows
Azoles nitrate.
Structural formula:
Molecular formula: C24H20Cl2N2OS·HNO3
Fenticonazole nitrate is imidazoles broad-spectrum antifungal medicine, for treating superficial mycosis and vaginal Candida infection.Should
Medicine went through to list in 1986 in Italy, and formulation has cream, spray and pessary.Its mechanism of action is by suppression
The hydroxylation of the cytochrome P-450 of fungal cell processed makes the Phospholipids of its cell membrane that unstable state is presented, and then makes
Fungal cell ruptures and necrosis, however, the medicine easily breaks the balance of nature of vagina, changes the microenvironment of vagina,
Drug withdrawal easily repeatedly, simultaneously because breaking the generation that colony balance is easily caused other vaginal diseases, treats the time with rehabilitation
It is long.It is as a result also unsatisfactory for the recent, late result acquired by it.And certain poison can be caused secondary
Effect, such as renal toxicity, hepatotoxicity wind agitation can also induce generation drug resistance.
Motherland's medical science thinks that vaginitis belongs to TCM Gynecology miscellaneous diseases pruritus vulvae and with lower category, and often mutually companion sees for both.Pruritus vulvae and
There are two aspect reasons with：One side and internal cause：Liver,kidney,spleen malfunction is closed, and liver arteries and veins is around external genitals, and main store blood, is
Viscus attriguted to wind and wood；Kidney controlling essence storage, main reproduction, have one's ideas straightened out Yu Eryin；The spleen has the function to transport and transform nutrients, and water is wet.If dampness-heat of liver channel or stagnation of liver-QI with deficiency of the spleenization fire are raw
Wet, damp and hot heresy is with through bet, penting up external genitals so pruritus vulvae；Or kidney deficiency and liver, blood and essence asthenia, raw weathering is dry, and private parts skin loses
Support, it is not flourish and itch；Still further aspect is relevant with external cause infection damp evil disease pest, because taking the photograph body accidentally, causes the intrusion of damp evil disease pest, worm disturbs the moon
Portion, sends out as pruritus vulvae.《Yizong Jinjian gynaecology heart method gist》Described " married woman's pruritus vulvae, more because of parasite caused by accumulation of damp-heat in the body " is this meaning.
Pruritus vulvae caused by infecting damp evil disease pest, with showing as dampness-heat of liver channel lower person more, thus treatment should remove with heat-clearing
Antipruritic wet, desinsection is principle.This disease is mainly because of damp-heat accumulation, and damp and hot heresy caused by during worm-eaten is cloudy has inside and outside point.As occupied long
Wetland etc. is caused to invade outside damp evil, strongly fragrant and change heat, or menstrual period, postpartum, toxic dampness and heat are taken advantage of a weak point, and this is that diseases caused by external factors are damp and hot.If ferritic spleen
The deficiency of vital energy is weak, or stagnation of liver qi, wooden gram spleen soil, the dysfunction of the spleen in transport, stays in water is wet, stops pouring down Jiao, accumulate and change heat, then damp and hot for interior life.
Damp-heat accumulation, ligament is not solid, then increases under band, and color is yellow.Damp-heat in lower-JIAO, the excellent then concurrent stranguria of failing to keep an appointment of wing；Damp evil contamination with the passing of time into
Poison, or infection heat toxin perverse trend, excess heat compel the absurd row of blood, or wet poison corrosion skin, then, it is seen that band defecation with blood and pus, or see " erosion of vulva ", " the moon
Sore ".Web rot is infested, or regimen is accidentally, and worm is evil straight to violate external genitals, then pruritus vulvae during worm-eaten is cloudy, though this disease of cusalgia is sick in external genitals in cloudy,
It is often relevant with the internal organs such as liver and spleen.
Sour Fenticonazole foreign countries listing formulation has creme, lotion, aerosol and soft gelatin pessary, and wherein lotion is gentle
Mist agent is short in the lesions position holdup time；Effective agent is generally dispersity in cream, ointment, is difficult to give full play to medicine
Effect, and be difficult cleaning after use；Suppository is suitable to cavity/canal drug administration, but can not fully be contacted with Lesional epidermal or mucous membrane, is not easy to medicine
What is imitated gives full play to, and in recent years, gel application study is increasingly paid attention to by domestic and foreign scholars.Gel has good
Bioadhesive and biocompatibility, epidermis or mucous membrane tight adhesion that can be with medicine-feeding part, be fixed on drug delivery system
Privileged site, extends the holdup time.Especially situ-gel, is administered with solution state, is fully contacted with Lesional epidermal or mucous membrane,
Occur phase in version in agents area after administration, it is long in the lesions position holdup time, the long-acting purpose of medicament slow release is can reach, is turned into
The focus that pharmacy is studied with biological technical field.
Motherland's therapeutic treatment vaginitis has had long history, and numerous studies are found in recent years, some Chinese medicines and its
Active ingredient has significant therapeutic effect to vaginitis, achieves some gratifying achievements, and clinical report obtains good treatment
Effect, therefore seek a kind of dosing techniques simplicity, the medicament valid density of medicine-feeding part can be maintained, and effectively can give medicament
The compound gel in medicine to the difficult place of administration is to put a technical barrier in face of medical field.
The content of the invention
It is easy it is an object of the invention to provide a kind of dosing techniques, the medicament valid density of medicine-feeding part can be maintained, and
Medicament effectively can be administered into compound fenticonazole nitrate preparation and its application in the difficult place of administration.Its purpose is to solve
Vaginitis, etc is certainly treated, overcomes single fenticonazole nitrate to work slow, is discontinued and easily waits substantially not enough repeatedly, and be administered not
The problems such as facilitating, reaches the purpose treated both principal and secondary aspect of disease.
Present inventor is according to forefathers' experience and oneself medical practice for many years, by the research to traditional Chinese medicine, and
With reference to dialectical demonstration, the multi-party length for collecting many families seeks therapeutic regimen, from motherland's medical treasure-house, filters out heat-clearing and remove
Wet, dispelling wind and arresting itching natural traditional Chinese medicine, by theory of traditional Chinese medical science prescription, the compound nitre of the present invention is configured to reference to Traditional Chinese Medicine technology meticulously
Sour Fenticonazole preparation, it takes stopgap measures vaginitis and effected a permanent cure.
To achieve the above object, the technical solution adopted by the present invention is as follows：
A kind of compound fenticonazole nitrate preparation, it is characterised in that be prepared by following raw materials,
Fenticonazole nitrate 10g, effective component of chinese medicine 10g, poloxamer188 30g, PLURONICS F87 15g, card ripple
Nurse 5g, propane diols 250g, glycerine 150g, sodium benzoate 5g, disodium ethylene diamine tetraacetate 0.3g, distilled water 475g.
The raw material that the effective component of chinese medicine is matched by following weight is prepared：：
35 parts of motherwort, 35 parts of polygonum perfoliatum, 30 parts of dandelion, 30 parts of plantain seed, 25 parts of golden cypress,
25 parts of reticulate millettia, 25 parts of hypoglaucous collett yam rhizome, 22 parts of the bark of eucommia, 20 parts of pseudo-ginseng, 20 parts of Ligusticum wallichii,
15 parts of the root of kudzu vine, 15 parts of cattail pollen, 10 parts of the root of Dahurain angelica, 10 parts of the Radix Astragali, 10 parts of lily, 10 parts of rhizoma cyperi,
10 parts of safflower, 5 parts of Artemisia anomala, 5 parts of madder, 5 parts of excrementum pteropi.
The preparation method of the effective component of chinese medicine is：
（1）Raw material is weighed according to proportioning；
（2）Take polygonum perfoliatum, dandelion, plantain seed, golden cypress, reticulate millettia, hypoglaucous collett yam rhizome, the bark of eucommia, the root of kudzu vine, cattail pollen, the root of Dahurain angelica, Huang
Stilbene, Artemisia anomala add 2 times of 90% alcohol dippings of weight 24 hours, and refluxing extraction twice, 1 hour every time, merges extract solution, is condensed into
Density is 1.1~1.2 g/ml medicinal extract, and crushed after being dried obtains A;
（3）Take residual components water boiling and extraction 2 times, the water for adding 5 times of weight is extracted for the first time, extraction time is 1 hour；
Second of extraction plus the water of 2 times of weight, extraction time are 1 hour；Filtration, merging filtrate is concentrated into density for 1.1~1.2 g/
Ml thick paste, crushed after being dried obtains compound B;
Mixed complex A and compound B produce effective component of chinese medicine.
The preparation method of the compound fenticonazole nitrate preparation is conventionally to prepare gel.
Preferably, by fenticonazole nitrate, effective component of chinese medicine, poloxamer188, PLURONICS F87, glycerine in 65 DEG C
Heating makes to be completely dissolved and is well mixed；
Sodium benzoate and disodium ethylene diamine tetraacetate are dissolved in distilled water, add carbomer and propane diols make it is fully molten
Solution/is swelled and is well mixed；
Above-mentioned solution is well mixed, produced.
The polymer selected in the present invention, with preferable bioadhesive and biocompatibility, upon administration with administration
Area skin or mucous membrane are fully contacted, and are detained the long period in medicine-feeding part, effective agent is in the specific of medicine-feeding part
Position, makes drug delivery system be positioned at specific medicine-feeding part, and effectively extension medicine makes medicine in the holdup time of medicine-feeding part
Thing reaches good slow release effect, is conducive to improving bioavilability, gives full play to drug effect.
Technical solutions according to the invention be on the basis of the clinical experience of Chinese traditional treatment vaginitis, with reference to modern pharmacy into
The compound preparation with Integrated TCM that fruit is developed.Chinese medicine and Western medicine are effectively combined, symptom can be improved rapidly, had
Effect controls inflammation, and prevents disease, has functions that healing to vaginitis, overcomes prior art drug effect slow and is discontinued easily
Side effect is waited repeatedly, the purpose treated both principal and secondary aspect of disease is reached, recommends medication：Vagina administration, in after clean period 2 one 3 days
Medication, smears appropriate, (menstrual period forbids medication) 7 days as one therapeutic course.
The compound fenticonazole nitrate preparation of the present invention obtains following effect：
1 it is comprehensive suit the vaginitis interpretation of the cause, onset and process of an illness, compound composition substantially reduces antibiotic dosage, and prescription is reasonable in order, and drug effect is deep
Enter persistently, medicine is simple and power is special；
2 present invention achieve preferable therapeutic effect, both meet country by the reasonable selection to medicine components, proportioning
Pharmacopeia can guarantee that good therapeutic effect, non-evident effect again to the requirement about drug dose.
Embodiment
Embodiment 1
A kind of compound fenticonazole nitrate preparation, it is characterised in that be prepared by following raw materials,
Fenticonazole nitrate 10g, effective component of chinese medicine 10g, poloxamer188 30g, PLURONICS F87 15g, card ripple
Nurse 5g, propane diols 250g, glycerine 150g, sodium benzoate 5g, disodium ethylene diamine tetraacetate 0.3g, distilled water 475g.
The raw material that the effective component of chinese medicine is matched by following weight is prepared：：
35 parts of motherwort, 35 parts of polygonum perfoliatum, 30 parts of dandelion, 30 parts of plantain seed, 25 parts of golden cypress,
25 parts of reticulate millettia, 25 parts of hypoglaucous collett yam rhizome, 22 parts of the bark of eucommia, 20 parts of pseudo-ginseng, 20 parts of Ligusticum wallichii,
15 parts of the root of kudzu vine, 15 parts of cattail pollen, 10 parts of the root of Dahurain angelica, 10 parts of the Radix Astragali, 10 parts of lily, 10 parts of rhizoma cyperi,
10 parts of safflower, 5 parts of Artemisia anomala, 5 parts of madder, 5 parts of excrementum pteropi.
The preparation method of the effective component of chinese medicine is：
（1）Raw material is weighed according to proportioning；
（2）Take polygonum perfoliatum, dandelion, plantain seed, golden cypress, reticulate millettia, hypoglaucous collett yam rhizome, the bark of eucommia, the root of kudzu vine, cattail pollen, the root of Dahurain angelica, Huang
Stilbene, Artemisia anomala add 2 times of 90% alcohol dippings of weight 24 hours, and refluxing extraction twice, 1 hour every time, merges extract solution, is condensed into
Density is 1.2 g/ml medicinal extract, and crushed after being dried obtains A;
（3）Take residual components water boiling and extraction 2 times, the water for adding 5 times of weight is extracted for the first time, extraction time is 1 hour；
Second of extraction plus the water of 2 times of weight, extraction time are 1 hour；Filtration, merging filtrate, it is 1.2 g/ml's to be concentrated into density
Thick paste, crushed after being dried obtains compound B;
Mixed complex A and compound B produce effective component of chinese medicine.
The preparation method of the compound fenticonazole nitrate preparation is：
Fenticonazole nitrate, effective component of chinese medicine, poloxamer188, PLURONICS F87, glycerine are made in 65 DEG C of heating
It is completely dissolved and is well mixed；Sodium benzoate and disodium ethylene diamine tetraacetate are dissolved in distilled water, by carbomer and the third two
Alcohol, which is added in above-mentioned solution, to be made fully dissolving/or is swelled and is well mixed；Above-mentioned solution is well mixed, produced.
Bioadhesive (bioadhesion in vitro experiment)
Test method：Two sections of the fresh vagina tissue of rabbit is taken, glass ampule bottom is individually fixed in, testing sample is applied
On two sections of vagina tissues and required temperature is reached, after two sections of vagina tissues are connected by testing sample, determined
Make two sections of two sections of vagina tissues sticked by gel separated peeling force just, and calculate Bioadhesive force (unit area
Peeling force).As a result it is as follows：N/cm
25 DEG C of adhesive forces（m N/cm2） 30.15；
33 DEG C of adhesive forces（m N/cm2） 38.73；
Embodiment 2
Toxicological study
1 acute toxicity test：
30 rabbit are randomly divided into 3 groups, every group 10, male and female half and half are lost hair or feathers to family's rabbit back with 10% vulcanized sodium, gone
Gross area about 150cm2.The making of damaged skin uses sterilization iron file that this hair is respectively applied after scratching (using oozing of blood as degree), unhairing
Bright preparation 0.2,0.5 and 0.7ml are in hair removal section and are fixed with nonirritant adhesive plaster, every animal sub-cage rearing, administration 24
1 after hour, 24,48,72 hours to the 7th day, observe and record body weight, fur, gloss, diet, eye and the mucous membrane of animal daily
Change, put to death rabbit after respiratory center, nervous system, four limbs activity and death condition, and Yu Qi, anatomic observation its heart,
The change of the internal organs such as liver, spleen, lung, kidney.
As a result：Gel prepared by the present invention is to the behavior of damaged skin rabbit, activity, diet, fur gloss, breathing
Maincenter, nervous system and body weight are without any harmful effect, and none rabbit is dead.Put to death rabbit after seven days, anatomic observation its heart,
The main organs no abnormality seen such as liver, spleen, lung, kidney.Therefore the compound preparation of the present invention does not cause on damaged skin to rabbit
Acute toxic reaction.
The chronic toxicity test carried out 6 months by a definite date, overall test results is administered orally to rat and dog in 2 long term toxicities
Show that tolerance is good.
3 irritation test results of study are shown：This product is normal to rabbit and damaged skin is showed no excitant；This product skin
Locally administration has no there is sensitization to cavy to skin.
4 reproductive toxicity tests will not change the reproductive function of first stage without interference with the gonad function of masculinity and femininity.
Reproductive toxicology studies have shown that has an embryology effect as other imidazole derivatives in high dose group, no sensitization,
Phototoxicity and photoallergy.
Mouse model is studied
The influence of medicine dialogue beads vaginitis model mouse vagina of the present invention
Experimental animal：ICR mouse, all female, body weight 18g-22g.
Trial drug：Gel prepared by embodiment 1；Contrast 1 group：JIEERYIN XIYE, it is commercially available；Contrast 2 groups
（CN103349755, fenticonazole nitrate suppository prepared by embodiment 1）
Modeling：Healthy mice 50 is taken, female, body weight 18-22g, wherein 10 mouse are as Normal group, remaining 40
Oestradiol benzoate 5mg/kg is only subcutaneously injected, once every other day, totally 3 times, mouse vagina is inoculated with Candida albicans within the 6th day, connects
The bacterium solution density planted is 9 × 108Individual/ml, every 20 μ L, once a day, totally three times, after modeling 10 days, observation modeling in the 11st day
As a result, method is to rinse mouse vagina with sterile PBS (phosphate buffer), collects irrigating solution, and smear is dyed, microscopy, mainly
The pseudohypha of Candida albicans is looked under the microscope, because the pseudohypha of Candida albicans just has the ability for settling down vagina mucosa,
So as to cause colpitis.The more mouse of 30 pseudohyphas is selected in 40 modeling mouse and carries out experiment packet administration：Just
Normal control group, deionized water；
30 successful mouse of modeling are taken to be randomly divided into 3 groups, every group 10,
First group of medicine group of the present invention, gives the gel of the preparation of embodiment 1,0.5ml/kg；
Second group of JIEERYIN XIYE group, mouse vagina 22.5mg/kg is rinsed per daily washing lotion；
3rd group of CN103349755 group, fills in mouse vagina 3.0g/kg suppositorys daily respectively；
Successive administration 7 days.Detection：After last dose 8 hours, start to rinse mouse vagina, every with sterile PBS liquid
20 μ L, collect irrigating solution, wherein 10 μ L smears, dyeing, microscopy, observation spore, pseudohypha, pseudohypha roll into a ball formational situation and to it
Amount is classified, to judge to infect the order of severity.The criteria for classifying is：Whole smear has no that pseudohypha is designated as 0, pseudohypha amount ＜ 10
1 is designated as, 2 are designated as between 10-30, has a pseudohypha group to be designated as 3, pseudohypha group ＞ 1 is designated as 4；10 μ L of residue add 1ml without
Diluted in bacterium PBS liquid, then 50 μ L are taken in dilution, be inoculated in husky fort culture medium, 30 DEG C are cultivated 48 hours, carry out CFU meters
Number (i.e. CFU, with bacterium colony number/L).After every mouse vagina irrigating solution takes, put to death, take mouse monilial infection
Vagina tissue, is fixed through 10% formalin, materials, routine paraffin wax embedding, serial section, 5 μm of thickness, and LEICA is used in HE dyeing
Biomicroscope is observed.First group of sterilizing rate is 99.72%, and second group of sterilizing rate is 89.60%, and the 3rd group of sterilizing rate is
92.75%, the medicine of embodiment 1 can make the pseudohypha in mouse vagina irrigating solution notable with the cloudy group of clean that, and CN103349755 groups
Reduce, and present invention group sterilizing rate is significantly increased (P ＜ 0.01, P ＜ 0.05) than other groups
Embodiment 3
Selection voluntarily receives the vaginitis patient 131 for the treatment of, inclusion criteria：Age more than 18 years old, non-menopause；It is clinical
Vaginitis is diagnosed, non-pregnancy, non-diabetic, tumour and other species reproductive organs infect, office was not applied in medical preceding January
Portion or whole body antifungal drug.It is randomly divided into two groups, treatment group and control group, wherein treatment group 66, control group 65, two groups
Patient age symptom is constituted without significant difference.With comparativity (P>0.05).
Treatment method
Each group Primary Care is consistent, and the compound Fenticonazole preparation of the preparation of embodiment 1 is given by treatment group, smears 1 time daily；
Control group gives the CN103349755 suppositorys of preparation, vagina administration, every time 1 piece.
The above each group menstrual period forbids medication, 7 days as one therapeutic course.
Clinical diagnosis：Vulva convulsion is itched/cusalgia, mucous hyperemia and leucorrhea increasing;Microexamination:Using sterile cotton swabs,
Sample is obtained from vaginal sidewall, cotton swab is put into censorship in physiological saline test tube.Using salt solution humidity strip method direct examination
(take a little curdy secretion to be placed on slide, plus one drop 10% potassium hydroxide or isotonic sodium chloride solution, be covered with lid
Slide, is placed under microscope, and it is that candida albicans is positive to have seen the life of oval bud and embraced son or pseudohypha).It is positive to all candida albicans
Patient gathers cloudy suitable secretion and does candida albicans culture simultaneously.Using the good Candida chromogenic medium of section's code, 24 ~ 48 are cultivated in 37 DEG C
H, culture to candida albicans is the positive.The API Candi-da reagents developed using French Mei Liai biotech firms, identification separation
Beads bacteria strain.
Efficacy assessment standard：Judge curative effect according to clinical symptoms, three indexs of sign and Mycology examination.
Cure：Subjective symptoms and sign are disappeared, and microscopy and culture are all turned out cloudy；
It is effective：Subjective symptoms and sign are clearly better, microscopy and culture is turned out cloudy or symptom, sign disappear, microscopy and culture
It is still once the positive；
It is invalid：Symptom, sign are with being compared unchanged or being aggravated before treatment, microscopy and culture are the positive.
Cure and added up to effectively with effective.
Clinical study results more than are shown
| Group | Number of cases | Cure | Effectively | It is invalid | It is efficient |
| Treatment group | 66 | 60 | 5 | 1 | 98.5% |
| Control group | 65 | 55 | 6 | 4 | 93.8% |
Treatment group is substantially better than control group compared with control group significant difference, medicine group of the present invention.
Above-mentioned each Chinese and Western medicine interaction compatibility that the present invention is used, can play it and cooperate with the effect of curing the disease, Chinese medicine material used is each
There is drug effect to be interweaved between composition and mutually promote and coordinate efficiency, the side effect that antibiotic is brought not only is greatly reduced,
And lasting medicine, according to clinical verification, there is good therapeutic effect to vaginitis, in the medical practice of the applicant for many years, cure
Case Numerous, obtain good effect, and with low cost, mitigate the burden of patient.
Claims (2)
1. a kind of compound fenticonazole nitrate preparation for treating vaginitis, it is characterised in that：The preparation is prepared by following compositions
And obtain,
Fenticonazole nitrate 10g, effective component of chinese medicine 10g, poloxamer188 30g, PLURONICS F87 15g, carbomer 5g,
Propane diols 250g, glycerine 150g, sodium benzoate 5g, disodium ethylene diamine tetraacetate 0.3g, distilled water 475g；
The raw material that the effective component of chinese medicine is matched by following weight is prepared：
35 parts of motherwort, 35 parts of polygonum perfoliatum, 30 parts of dandelion, 30 parts of plantain seed, 25 parts of golden cypress,
25 parts of reticulate millettia, 25 parts of hypoglaucous collett yam rhizome, 22 parts of the bark of eucommia, 20 parts of pseudo-ginseng, 20 parts of Ligusticum wallichii,
15 parts of the root of kudzu vine, 15 parts of cattail pollen, 10 parts of the root of Dahurain angelica, 10 parts of the Radix Astragali, 10 parts of lily, 10 parts of rhizoma cyperi,
10 parts of safflower, 5 parts of Artemisia anomala, 5 parts of madder, 5 parts of excrementum pteropi.
2. preparation according to claim 1, it is characterised in that the preparation method of the effective component of chinese medicine includes following step
Suddenly：
（1）Each raw material for standby is weighed according to proportioning；
（2）Take polygonum perfoliatum, dandelion, plantain seed, golden cypress, reticulate millettia, hypoglaucous collett yam rhizome, the bark of eucommia, the root of kudzu vine, cattail pollen, the root of Dahurain angelica, the Radix Astragali, Liu
Post slave, plus 2 times of 90% alcohol dippings of weight 24 hours, refluxing extraction twice, 1 hour every time, merges extract solution, is condensed into density
For 1.1~1.2 g/ml medicinal extract, crushed after being dried obtains compound A；
（3）Take surplus stock to mix, with water boiling and extraction 2 times, extract for the first time plus 5 times of weight water, extraction time is 1 small
When；Second of extraction plus the water of 2 times of weight, extraction time are 1 hour；Filtration, merging filtrate, it is 1.1~1.2 to be concentrated into density
G/ml thick paste, crushed after being dried obtains compound B；
（4）Mixed complex A and compound B are produced.
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| CN103349755A (en) * | 2013-07-08 | 2013-10-16 | 林凡友 | Fenticonazole nitrate and synthesis process thereof |
Non-Patent Citations (2)
| Title |
|---|
| 中药熏洗为主治疗霉菌性阴道炎56例;王艳等;《河南中医》;20071010;第27卷(第10期);第46-47页 * |
| 阴痒熏洗液治疗阴道炎150例;朱丽君;《辽宁中医杂志》;19961118;第23卷(第11期);第506页 * |
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