CN105832693A - 一种抑郁药专用空心胶囊的制备方法 - Google Patents

一种抑郁药专用空心胶囊的制备方法 Download PDF

Info

Publication number
CN105832693A
CN105832693A CN201610155472.3A CN201610155472A CN105832693A CN 105832693 A CN105832693 A CN 105832693A CN 201610155472 A CN201610155472 A CN 201610155472A CN 105832693 A CN105832693 A CN 105832693A
Authority
CN
China
Prior art keywords
capsule
stirring
glue
hypericin
sodium hyaluronate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610155472.3A
Other languages
English (en)
Inventor
陈兴权
王志慧
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Changzhou Amante Chemical Engineering Co Ltd
Original Assignee
Changzhou Amante Chemical Engineering Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Changzhou Amante Chemical Engineering Co Ltd filed Critical Changzhou Amante Chemical Engineering Co Ltd
Priority to CN201610155472.3A priority Critical patent/CN105832693A/zh
Publication of CN105832693A publication Critical patent/CN105832693A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00Preparation of quinones
    • C07C46/10Separation; Purification; Stabilisation; Use of additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明公开了一种抑郁药专用空心胶囊的制备方法,属于胶囊领域。本发明从新鲜贯叶连翘提取得金丝桃素浓缩液,再制备交联透明质酸钠凝胶,将其与黄原胶、金丝桃素浓缩液表面活性剂、助凝剂、固化剂等混合制备成胶液,将胶液送入胶囊生产线生产成型即可,本发明制备得的空心胶囊的原料流动性好,壁厚均匀,而且提取出金丝桃素添加到囊体中,使得囊体不仅仅只是药剂的外包材料,而且具有抗抑郁的功效,可以应用于抗抑郁药之中,增强药效、延长缓释效果。

Description

一种抑郁药专用空心胶囊的制备方法
技术领域
本发明公开了一种抑郁药专用空心胶囊的制备方法,属于胶囊领域。
背景技术
硬壳空心胶囊是一种重要的药辅材料。它是随制剂一起进入人体消化系统后再被人体所吸收,故食用的安全性与空心胶囊的质量安全标准息息相关。目前市场上的空心胶囊仍以明胶胶囊为主,而明胶胶囊的缺陷也日益明显,研发植物空心胶囊在国内外广受关注。植物空心胶囊的应用市场显现出了极大的发展潜力我国植物空心胶囊制备技术较欧美国家仍较落后,而用于植物空心胶囊制备的材料包括羟甲基纤维素、多糖及淀粉类。
目前,空心胶囊的生产过程中容易发生以下问题:若产品原料的含水低,则原料的流动性差,均质性差,生产出的空心胶囊因各位点的材质、壁厚不一而成品合格率低;若增加产品原料的含水量,原料的流动性提高,则产品的干燥成型过程变长,电耗增加,而且由于失水多,产品成型的不确定性增加,同样影响成品合格率,现有的生产工艺制备的空心胶囊具有壁厚不一,含水量差异大,合格率低,能耗高的缺点。
发明内容
本发明主要解决的技术问题:针对目前空心胶囊具有壁厚不一,含水量差异大,合格率低,能耗高,而且功能单一的问题,提供了一种抑郁药专用空心胶囊的制备方法,本发明从新鲜贯叶连翘提取得金丝桃素浓缩液,再制备交联透明质酸钠凝胶,将其与黄原胶、金丝桃素浓缩液表面活性剂、助凝剂、固化剂等混合制备成胶液,将胶液送入胶囊生产线生产成型即可,本发明制备得的空心胶囊的原料流动性好,壁厚均匀,而且提取出金丝桃素添加到囊体中,使得囊体不仅仅只是药剂的外包材料,而且具有抗抑郁的功效,可以应用于抗抑郁药之中,增强药效、延长缓释效果。
为了解决上述技术问题,本发明所采用的技术方案是:
(1)取60~80g新鲜贯叶连翘,将其烘干后粉碎、过筛得贯叶连翘粉末,按固液比1:8与质量分数90%乙醇混合,混合后在120~140W功率下超声提取20~30min,得到提取液,用质量分数盐酸调节提取液pH为5.0~5.5,调节后离心分离得上清液,将上清液通过大孔树脂柱,用质量分数25%乙醇进行洗脱,收集洗脱液,将洗脱液在50~60℃下蒸发浓缩至30~40mL,得金丝桃素浓缩液,备用;
(2)在500mL三口烧瓶中,加入5~8g己二酸二酰肼和60~70mL质量分数15%盐酸,搅拌溶解后称取55~65g透明质酸钠干粉,将干粉缓慢加入到烧瓶中,在常温和150~200r/min转速下搅拌混合15~20min,搅拌后用浓度0.1mol/L的氢氧化钠或0.1mol/L盐酸调节pH值为4.5~10.5,继续搅拌1~2h,得到稳定的交联透明质酸钠凝胶,再加入50~80mL柠檬酸缓冲溶液,搅拌溶胀至凝胶不粘壁即可;
(3)将20~25g上述交联透明质酸钠凝胶于500mL反应器中,加热至85~90℃,
向反应器中依次加入10~15g黄原胶,0.2~0.5g十二烷基硫酸钠,5~10g柠檬酸钾和30~40mL步骤(1)金丝桃素浓缩液,搅拌混合至形成透明溶液,搅拌后降温至45~50℃,并加入5~7g羟丙基甲基纤维素和20~30mL聚乙二醇,保温30~50min,融化为均匀的胶液,并除去液面上的泡沫;
(4)将上述制得的胶液继续保温静置2~2.5h,静置后送入胶囊生产线,将送入胶囊生产线的胶液进行蘸胶,翻转数次后冷却成型,送入烘箱内在45~55℃下烘干得到初囊体;
(5)将初囊体再用交联透明质酸钠凝胶进行一次包衣,然后放入鼓风干燥机中干燥,拔下囊胚,切割成规定长度,即可制成空心胶囊成品。
本发明的应用的方法:采用有机玻璃制成的胶囊板填充,板分上下两层,上层有数百孔洞,先将本发明制得的囊帽、囊身分开,囊身插入胶囊板孔洞中,调节上下层距离,使胶囊口与板面相平,将抑郁药剂颗粒铺于板面,轻轻振动胶囊板,使抑郁药剂颗粒填充均匀,填满每个胶囊后,将板面多余颗粒扫除,顶起囊身,套合囊帽,取出胶囊,即得。
本发明的有益效果是:
(1)本发明制备得的空心胶囊的原料流动性好,壁厚均匀,制备工艺简单,成本低;
(2)本发明提取出金丝桃素添加到囊体中,使得囊体不仅仅只是药剂的外包材料,而且具有抗抑郁的功效,可以应用于抗抑郁药之中,增强药效、延长缓释效果。
具体实施方式
首先取60~80g新鲜贯叶连翘,将其烘干后粉碎、过筛得贯叶连翘粉末,按固液比1:8与质量分数90%乙醇混合,混合后在120~140W功率下超声提取20~30min,得到提取液,用质量分数盐酸调节提取液pH为5.0~5.5,调节后离心分离得上清液,将上清液通过大孔树脂柱,用质量分数25%乙醇进行洗脱,收集洗脱液,将洗脱液在50~60℃下蒸发浓缩至30~40mL,得金丝桃素浓缩液,备用;在500mL三口烧瓶中,加入5~8g己二酸二酰肼和60~70mL质量分数15%盐酸,搅拌溶解后称取55~65g透明质酸钠干粉,将干粉缓慢加入到烧瓶中,在常温和150~200r/min转速下搅拌混合15~20min,搅拌后用浓度0.1mol/L的氢氧化钠或0.1mol/L盐酸调节pH值为4.5~10.5,继续搅拌1~2h,得到稳定的交联透明质酸钠凝胶,再加入50~80mL柠檬酸缓冲溶液,搅拌溶胀至凝胶不粘壁即可;将20~25g交联透明质酸钠凝胶于500mL反应器中,加热至85~90℃,
向反应器中依次加入10~15g黄原胶,0.2~0.5g十二烷基硫酸钠,5~10g柠檬酸钾和30~40mL金丝桃素浓缩液,搅拌混合至形成透明溶液,搅拌后降温至45~50℃,并加入5~7g羟丙基甲基纤维素和20~30mL聚乙二醇,保温30~50min,融化为均匀的胶液,并除去液面上的泡沫;将制得的胶液继续保温静置2~2.5h,静置后送入胶囊生产线,将送入胶囊生产线的胶液进行蘸胶,翻转数次后冷却成型,送入烘箱内在45~55℃下烘干得到初囊体;将初囊体再用交联透明质酸钠凝胶进行一次包衣,然后放入鼓风干燥机中干燥,拔下囊胚,切割成规定长度,即可制成空心胶囊成品。
实例1
首先取60g新鲜贯叶连翘,将其烘干后粉碎、过筛得贯叶连翘粉末,按固液比1:8与质量分数90%乙醇混合,混合后在120W功率下超声提取20min,得到提取液,用质量分数盐酸调节提取液pH为5.0,调节后离心分离得上清液,将上清液通过大孔树脂柱,用质量分数25%乙醇进行洗脱,收集洗脱液,将洗脱液在50℃下蒸发浓缩至30mL,得金丝桃素浓缩液,备用;在500mL三口烧瓶中,加入5g己二酸二酰肼和60mL质量分数15%盐酸,搅拌溶解后称取55g透明质酸钠干粉,将干粉缓慢加入到烧瓶中,在常温和150r/min转速下搅拌混合15min,搅拌后用浓度0.1mol/L的氢氧化钠或0.1mol/L盐酸调节pH值为4.5,继续搅拌1h,得到稳定的交联透明质酸钠凝胶,再加入50mL柠檬酸缓冲溶液,搅拌溶胀至凝胶不粘壁即可;将20g交联透明质酸钠凝胶于500mL反应器中,加热至85℃,
向反应器中依次加入10g黄原胶,0.2g十二烷基硫酸钠,5g柠檬酸钾和30mL金丝桃素浓缩液,搅拌混合至形成透明溶液,搅拌后降温至45℃,并加入5g羟丙基甲基纤维素和20mL聚乙二醇,保温30min,融化为均匀的胶液,并除去液面上的泡沫;将制得的胶液继续保温静置2h,静置后送入胶囊生产线,将送入胶囊生产线的胶液进行蘸胶,翻转数次后冷却成型,送入烘箱内在45℃下烘干得到初囊体;将初囊体再用交联透明质酸钠凝胶进行一次包衣,然后放入鼓风干燥机中干燥,拔下囊胚,切割成规定长度,即可制成空心胶囊成品。
采用有机玻璃制成的胶囊板填充,板分上下两层,上层有数百孔洞,先将本发明制得的囊帽、囊身分开,囊身插入胶囊板孔洞中,调节上下层距离,使胶囊口与板面相平,将抑郁药剂颗粒铺于板面,轻轻振动胶囊板,使药剂颗粒填充均匀,填满每个胶囊后,将板面多余颗粒扫除,顶起囊身,套合囊帽,取出胶囊,即得。
实例2
首先取70g新鲜贯叶连翘,将其烘干后粉碎、过筛得贯叶连翘粉末,按固液比1:8与质量分数90%乙醇混合,混合后在130W功率下超声提取25min,得到提取液,用质量分数盐酸调节提取液pH为5.3,调节后离心分离得上清液,将上清液通过大孔树脂柱,用质量分数25%乙醇进行洗脱,收集洗脱液,将洗脱液在55℃下蒸发浓缩至35mL,得金丝桃素浓缩液,备用;在500mL三口烧瓶中,加入7g己二酸二酰肼和65mL质量分数15%盐酸,搅拌溶解后称取60g透明质酸钠干粉,将干粉缓慢加入到烧瓶中,在常温和175r/min转速下搅拌混合17min,搅拌后用浓度0.1mol/L的氢氧化钠或0.1mol/L盐酸调节pH值为7.0,继续搅拌1.5h,得到稳定的交联透明质酸钠凝胶,再加入65mL柠檬酸缓冲溶液,搅拌溶胀至凝胶不粘壁即可;将23g交联透明质酸钠凝胶于500mL反应器中,加热至87℃,向反应器中依次加入13g黄原胶,0.3g十二烷基硫酸钠,7g柠檬酸钾和35mL金丝桃素浓缩液,搅拌混合至形成透明溶液,搅拌后降温至47℃,并加入6g羟丙基甲基纤维素和25mL聚乙二醇,保温40min,融化为均匀的胶液,并除去液面上的泡沫;将制得的胶液继续保温静置2.3h,静置后送入胶囊生产线,将送入胶囊生产线的胶液进行蘸胶,翻转数次后冷却成型,送入烘箱内在50℃下烘干得到初囊体;将初囊体再用交联透明质酸钠凝胶进行一次包衣,然后放入鼓风干燥机中干燥,拔下囊胚,切割成规定长度,即可制成空心胶囊成品。
采用有机玻璃制成的胶囊板填充,板分上下两层,上层有数百孔洞,先将本发明制得的囊帽、囊身分开,囊身插入胶囊板孔洞中,调节上下层距离,使胶囊口与板面相平,将抑郁药剂颗粒铺于板面,轻轻振动胶囊板,使药剂颗粒填充均匀,填满每个胶囊后,将板面多余颗粒扫除,顶起囊身,套合囊帽,取出胶囊,即得。
实例3
首先取80g新鲜贯叶连翘,将其烘干后粉碎、过筛得贯叶连翘粉末,按固液比1:8与质量分数90%乙醇混合,混合后在140W功率下超声提取30min,得到提取液,用质量分数盐酸调节提取液pH为5.5,调节后离心分离得上清液,将上清液通过大孔树脂柱,用质量分数25%乙醇进行洗脱,收集洗脱液,将洗脱液在60℃下蒸发浓缩至40mL,得金丝桃素浓缩液,备用;在500mL三口烧瓶中,加入8g己二酸二酰肼和70mL质量分数15%盐酸,搅拌溶解后称取65g透明质酸钠干粉,将干粉缓慢加入到烧瓶中,在常温和200r/min转速下搅拌混合20min,搅拌后用浓度0.1mol/L的氢氧化钠或0.1mol/L盐酸调节pH值为10.5,继续搅拌2h,得到稳定的交联透明质酸钠凝胶,再加入80mL柠檬酸缓冲溶液,搅拌溶胀至凝胶不粘壁即可;将25g交联透明质酸钠凝胶于500mL反应器中,加热至90℃,向反应器中依次加入15g黄原胶,0.5g十二烷基硫酸钠,10g柠檬酸钾和40mL金丝桃素浓缩液,搅拌混合至形成透明溶液,搅拌后降温至50℃,并加入7g羟丙基甲基纤维素和30mL聚乙二醇,保温50min,融化为均匀的胶液,并除去液面上的泡沫;将制得的胶液继续保温静置2.5h,静置后送入胶囊生产线,将送入胶囊生产线的胶液进行蘸胶,翻转数次后冷却成型,送入烘箱内在55℃下烘干得到初囊体;将初囊体再用交联透明质酸钠凝胶进行一次包衣,然后放入鼓风干燥机中干燥,拔下囊胚,切割成规定长度,即可制成空心胶囊成品。
采用有机玻璃制成的胶囊板填充,板分上下两层,上层有数百孔洞,先将本发明制得的囊帽、囊身分开,囊身插入胶囊板孔洞中,调节上下层距离,使胶囊口与板面相平,将抑郁药剂颗粒铺于板面,轻轻振动胶囊板,使药剂颗粒填充均匀,填满每个胶囊后,将板面多余颗粒扫除,顶起囊身,套合囊帽,取出胶囊,即得。

Claims (1)

1.一种抑郁药专用空心胶囊的制备方法,其特征在于具体制备步骤为:
(1)取60~80g新鲜贯叶连翘,将其烘干后粉碎、过筛得贯叶连翘粉末,按固
液比1:8与质量分数90%乙醇混合,混合后在120~140W功率下超声提取20~30min,得到提取液,用质量分数盐酸调节提取液pH为5.0~5.5,调节后离心分离得上清液,将上清液通过大孔树脂柱,用质量分数25%乙醇进行洗脱,收集洗脱液,将洗脱液在50~60℃下蒸发浓缩至30~40mL,得金丝桃素浓缩液,备用;
(2)在500mL三口烧瓶中,加入5~8g己二酸二酰肼和60~70mL质量分数15%
盐酸,搅拌溶解后称取55~65g透明质酸钠干粉,将干粉缓慢加入到烧瓶中,在常温和150~200r/min转速下搅拌混合15~20min,搅拌后用浓度0.1mol/L的氢氧化钠或0.1mol/L盐酸调节pH值为4.5~10.5,继续搅拌1~2h,得到稳定的交联透明质酸钠凝胶,再加入50~80mL柠檬酸缓冲溶液,搅拌溶胀至凝胶不粘壁即可;
(3)将20~25g上述交联透明质酸钠凝胶于500mL反应器中,加热至85~90℃,
向反应器中依次加入10~15g黄原胶,0.2~0.5g十二烷基硫酸钠,5~10g柠檬酸钾和30~40mL步骤(1)金丝桃素浓缩液,搅拌混合至形成透明溶液,搅拌后降温至45~50℃,并加入5~7g羟丙基甲基纤维素和20~30mL聚乙二醇,保温30~50min,融化为均匀的胶液,并除去液面上的泡沫;
(4)将上述制得的胶液继续保温静置2~2.5h,静置后送入胶囊生产线,将送入胶囊生产线的胶液进行蘸胶,翻转数次后冷却成型,送入烘箱内在45~55℃下烘干得到初囊体;
(5)将初囊体再用交联透明质酸钠凝胶进行一次包衣,然后放入鼓风干燥机中干燥,拔下囊胚,切割成规定长度,即可制成空心胶囊成品。
CN201610155472.3A 2016-03-18 2016-03-18 一种抑郁药专用空心胶囊的制备方法 Pending CN105832693A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610155472.3A CN105832693A (zh) 2016-03-18 2016-03-18 一种抑郁药专用空心胶囊的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610155472.3A CN105832693A (zh) 2016-03-18 2016-03-18 一种抑郁药专用空心胶囊的制备方法

Publications (1)

Publication Number Publication Date
CN105832693A true CN105832693A (zh) 2016-08-10

Family

ID=56587375

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610155472.3A Pending CN105832693A (zh) 2016-03-18 2016-03-18 一种抑郁药专用空心胶囊的制备方法

Country Status (1)

Country Link
CN (1) CN105832693A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108553444A (zh) * 2018-04-25 2018-09-21 常州市阿曼特医药科技有限公司 一种保健空心胶囊及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1875954A (zh) * 2001-09-25 2006-12-13 北京北大维信生物科技有限公司 一种治疗抑郁症的口服药—金玉康
CN1895235A (zh) * 2006-06-29 2007-01-17 郑建璋 银耳多糖胶囊生产方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1875954A (zh) * 2001-09-25 2006-12-13 北京北大维信生物科技有限公司 一种治疗抑郁症的口服药—金玉康
CN1895235A (zh) * 2006-06-29 2007-01-17 郑建璋 银耳多糖胶囊生产方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
李宇亮等: "贯叶连翘中金丝桃素提取分离方法研究", 《应用化工》 *
聂素云: "改性透明质酸药物载体的制备及性能研究", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108553444A (zh) * 2018-04-25 2018-09-21 常州市阿曼特医药科技有限公司 一种保健空心胶囊及其制备方法

Similar Documents

Publication Publication Date Title
CN104059598B (zh) 一种大豆蛋白改性胶无醛中密度纤维板的制作方法
CN103495176B (zh) 一种共混挤出法制备淀粉基软胶囊的方法
CN105832693A (zh) 一种抑郁药专用空心胶囊的制备方法
CN107316743A (zh) 一种干式电力电子电容器的浇注工艺
CN103933010A (zh) 一种肠溶植物空心胶囊的制作工艺
CN102153783B (zh) 利用羧甲基化马铃薯薯渣制备的可食性包装膜及制备方法
CN104798975B (zh) 一种普鲁兰多糖爽口片生产过程粘板的解决方法
CN103315976B (zh) 一种淀粉硬胶囊壳的制备方法
CN109608657A (zh) 一种新型离子液体降解木质素的方法
CN103725418A (zh) 一种用离子液体提取菠萝蜜香薰油的方法
CN104055832B (zh) 一种黄芪破壁制剂
CN107496372A (zh) 一种茶叶植物软胶囊壳及其用途和茶叶植物软胶囊的制备方法
CN103450580A (zh) 以废弃聚氨酯泡沫、废弃植物纤维及废弃聚苯乙烯泡沫制备板材的方法
CN101338045B (zh) 木薯淀粉植物胶的制备工艺及其制得的植物胶、植物胶囊
CN103711043A (zh) 一种改善木纤维模压填充性能的成型工艺
CN103948606B (zh) 阿咖酚散及其制备方法
CN102896716A (zh) 热浇注模具脱模剂及制备方法
CN203938631U (zh) 利用负压渗透法生产无机改性聚苯板的装置
CN203407460U (zh) 一种黑茶自动控制渥堆设备
CN111870587A (zh) 一种添加β-环糊精的薄膜包衣预混剂制备方法
CN106138008A (zh) 植物性硬胶囊及其制备方法
CN205729806U (zh) 一种胶囊自动填充装置
CN101219459A (zh) 实模铸造甘蔗压榨辊壳的方法
CN106519269A (zh) 一种二氧六环/水共混溶液预处理竹粉制备木质纤维素再生膜的方法
CN111317765A (zh) 一种龟胶养阴颗粒的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20160810