CN105820949A - Nucleic acid isolation machine, injection device thereof and injection device control method - Google Patents
Nucleic acid isolation machine, injection device thereof and injection device control method Download PDFInfo
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- CN105820949A CN105820949A CN201610292130.6A CN201610292130A CN105820949A CN 105820949 A CN105820949 A CN 105820949A CN 201610292130 A CN201610292130 A CN 201610292130A CN 105820949 A CN105820949 A CN 105820949A
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- fluid
- hole
- injection device
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
Abstract
The invention discloses a nucleic acid isolation machine, an injection device thereof and an injection device control method. The injection device comprises a fluid pipeline, a first piezoelectric actuator, a first pressure sensor and a control unit, wherein one end of the fluid pipeline is connected with a fluid supply pipeline, the first piezoelectric actuator is connected with the other end of the fluid pipeline, a hole for fluid to pass through is formed in the middle of the first piezoelectric actuator, and the fluid flowing into the fluid pipeline from the fluid supply pipeline flows out of the hole; the first pressure sensor is arranged on the side wall of the hole and used for detecting pressure value on the side wall of the hole when the fluid flows out of the hole; the control unit is used for sending out a control signal to control increase of the hole diameter by adjusting the voltage value of the first piezoelectric actuator when the value, detected by the first pressure sensor, of pressure on the side wall of the hole by the fluid is larger than a first preset threshold value. The technical problem that in the prior art, an injection device of the nucleic acid isolation machine sprays the solution at high speed to cause solution spill and then affect the nucleic acid extraction process is solved, and solution spatter is avoided.
Description
Technical field
The present invention relates to nucleic acid extraction field, be specifically related to a kind of instrument for extracting nucleic acid and injection device thereof and injection device control method.
Background technology
Instrument for extracting nucleic acid, is the instrument extracting work applying supporting nucleic acid extracting reagent to be automatically performed sample nucleic acid, and instrument for extracting nucleic acid is divided into two classes: a class is large-scale automatization, commonly referred to as automated fluid work station；Another kind of is small-sized automatic instrument for extracting nucleic acid, utilizes packaged matched reagent to be automatically performed extraction purification process.Large-scale automated fluid work station is because equipment cost is high, and operating cost is high, is suitable for once extracting thousand of one species specimen, so be really applied is fewer；And the instrument of small automatic, because instrument and equipment and operating cost are low, easy to operate, obtain increasing application.
The method for extracting nucleic acid of the proposition such as the most gloomy Shou Hong and nucleic acid-extracting apparatus (CN101886037A) disclose a kind of nucleic acid-extracting apparatus, belong to the instrument of small automatic, utilize this nucleic acid-extracting apparatus to process the sample solution containing nucleic acid, there is efficient, easy, quick, good automatization's adaptability and the advantage of good repeatability.Cleaning mixture is dispensed into multiple in the nucleic acid extraction column of arrangement by the first dispensing mouth by this device, is dispensed into by recovered liquid multiple in the nucleic acid extraction column of arrangement by the second dispensing mouth.But, in the program when dispensing mouth occurs that obstruction or liquid inventory are excessive so that too fast from the solution speed of dispensing mouth ejection, it is easily caused the solution being injected in extraction column and spills, and then affect nucleic acid extraction process.
Summary of the invention
Therefore, the technical problem to be solved in the present invention is that the solution speed of the injection device ejection of instrument for extracting nucleic acid of the prior art causes solution to spill soon, and then affects nucleic acid extraction process.
According to an aspect of the present invention, it is provided that a kind of injection device for instrument for extracting nucleic acid, including: fluid line, its one end is connected with pipeline for fluids；First piezo-activator, is connected with the other end of described fluid line, and the middle part of described first piezo-activator has the hole passed through for fluid, and the fluid flowing into described fluid line from described pipeline for fluids flows out from described hole；First pressure transducer, is arranged on the sidewall in described hole, for detecting when fluid flows out the force value of the sidewall to described hole from described hole；Control unit, the described fluid for detecting according to described first pressure transducer sends control signal when the force value of the sidewall in described hole is more than the first predetermined threshold value, to control the aperture increase in described hole by regulating the magnitude of voltage of the first piezo-activator.
Preferably, described injection device also includes: the second piezo-activator, is positioned on the tube wall of described fluid line, and the described control signal for sending according to described control unit regulates the pipe diameter size of described fluid line.
Preferably, described injection device also includes: the second pressure transducer, is arranged on the inner tubal wall of described fluid line, is connected with described control unit, for detecting the described fluid pressure to the inner tubal wall of described fluid line；Wherein, described control unit is additionally operable to according to the described fluid pipe diameter size to fluid line described in the pressure size adjustment of the inner tubal wall of described fluid line.
Preferably, described control unit is respectively connected with described first piezo-activator and described first pressure transducer.
Preferably, described first pressure transducer is multiple, wherein, described control unit is additionally operable to calculate the meansigma methods of multiple force value corresponding to pressure signal that multiple described first pressure transducer detects, and by judging whether described meansigma methods reaches described first predetermined threshold value and judge that the described fluid force value to the sidewall in described hole is more than described first predetermined threshold value.
Preferably, described instrument for extracting nucleic acid includes micropump, for pumping described fluid to described pipeline for fluids, described control unit is additionally operable to reduce the rotating speed of described micropump when the described fluid that described first pressure transducer detects reaches the second predetermined threshold value to the force value of the sidewall in described hole.
According to another aspect of the present invention, additionally provide a kind of injection device control method for instrument for extracting nucleic acid, including: receive the pressure signal that the first pressure transducer detects, wherein, described first pressure transducer is the force value for detecting when fluid flows out the sidewall to described hole from the hole of injection device；Judge whether the force value that described pressure signal is corresponding reaches the first predetermined threshold value；When judging that described force value reaches described first predetermined threshold value, send control signal, to control the aperture increase in described hole by regulating the magnitude of voltage of the first piezo-activator, wherein, the middle part of described first piezo-activator has the described hole passed through for described fluid.
Preferably, described first pressure transducer is multiple, and whether the described force value judging that described pressure signal is corresponding reaches the first predetermined threshold value includes: calculate the meansigma methods of multiple force value corresponding to pressure signal that multiple described first pressure transducer detects；Judge whether described meansigma methods reaches the first predetermined threshold value.
Preferably, after judging that described force value reaches described first predetermined threshold value, described method also includes: judge whether described force value reaches the second predetermined threshold value, and wherein, described second predetermined threshold value is more than described first predetermined threshold value；When judging that described force value reaches described second predetermined threshold value, reduce the rotating speed of the micropump of instrument for extracting nucleic acid.
According to another aspect of the present invention, a kind of instrument for extracting nucleic acid is additionally provided, it is characterised in that including: above-mentioned injection device.
The embodiment of the present invention detects the fluid force value to the sidewall in hole by arranging the first pressure transducer on the sidewall in hole, control unit is when the force value that the first pressure transducer examined detects is more than the first predetermined threshold value, send control signal, increase with the aperture of the magnitude of voltage control hole by regulating the first piezo-activator, so that in the case of the solution of ejection same volume, the speed of ejection is reduced, the solution speed of the injection device ejection solving instrument for extracting nucleic acid of the prior art causes solution to spill soon, and then affect the technical problem of nucleic acid extraction process, the situation avoiding solution splash occurs.
Accompanying drawing explanation
In order to be illustrated more clearly that the specific embodiment of the invention or technical scheme of the prior art, the accompanying drawing used required in detailed description of the invention or description of the prior art will be briefly described below, apparently, accompanying drawing in describing below is some embodiments of the present invention, for those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the axial sectional view of flow controllable nozzles in the embodiment of the present invention 1 for nucleic acid automatic extracting instrument；
Fig. 2 is the top view of the flow controllable nozzles for nucleic acid automatic extracting instrument of another concrete example in the embodiment of the present invention 1；
Fig. 3 is the flow chart of injection device control method in the embodiment of the present invention 2 for instrument for extracting nucleic acid.
Reference: 10-fluid line, 20-the first piezo-activator, 30-the first pressure transducer, 40-the second piezo-activator, 50-the second pressure transducer, 201-hole, f1, f2, f3-deformation direction.
Detailed description of the invention
Below in conjunction with accompanying drawing, technical scheme is clearly and completely described, it is clear that described embodiment is a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into the scope of protection of the invention.
In describing the invention, it should be noted that, orientation or the position relationship of the instruction such as term " " center ", " on ", D score, "left", "right", " vertically ", " level ", " interior ", " outward " be based on orientation shown in the drawings or position relationship; be for only for ease of the description present invention and simplifying and describe; rather than instruction or imply indication device or element must have specific orientation, with specific azimuth configuration and operation, be therefore not considered as limiting the invention.Additionally, term " first ", " second ", " the 3rd " are only used for describing purpose, and it is not intended that instruction or hint relative importance.
In describing the invention, it should be noted that unless otherwise clearly defined and limited, term " is installed ", " being connected ", " connection " should be interpreted broadly, and connects for example, it may be fixing, it is also possible to be to removably connect, or be integrally connected；Can be to be mechanically connected, it is also possible to be electrical connection；Can be to be joined directly together, it is also possible to be indirectly connected to by intermediary, it is also possible to be the connection of two element internals, can be wireless connections, it is also possible to be wired connection.For the ordinary skill in the art, above-mentioned term concrete meaning in the present invention can be understood with concrete condition.
As long as just can be combined with each other additionally, technical characteristic involved in invention described below difference embodiment does not constitutes conflict each other.
Embodiment 1
Embodiments provide a kind of injection device for instrument for extracting nucleic acid, as it is shown in figure 1, this device includes: fluid line the 10, first piezo-activator the 20, first pressure transducer 30 and control unit (not shown).
Its one end of fluid line 10 is connected with pipeline for fluids.Wherein, pipeline for fluids is for injecting fluid to injection device, and this fluid could be for extracting the sample solution of nucleic acid, it is also possible to is cleaning mixture etc..
The other end and first piezo-activator 20 of fluid line 10 connect, wherein, the middle part of the first piezo-activator 20 has the hole 201 passed through for fluid, flows out (fluid flows) along f1 direction from hole 201 from the fluid of pipeline for fluids incoming fluid pipeline 10.First piezo-activator 20 can deform upon to along f2 direction in the control of control unit, thus changes the pore size in hole 201.
First pressure transducer 30 is arranged on the sidewall in hole 201, for detecting when fluid flows out the force value of the sidewall to hole from hole.
Control unit sends control signal when the fluid detected according to the first pressure transducer 30 is more than the first predetermined threshold value to the force value of the sidewall in hole 201, increases with the aperture of the magnitude of voltage control hole 201 by regulating the first piezo-activator 20.Preferably, control unit is respectively connected with (not shown) with the first piezo-activator 20 and the first pressure transducer 30, and wherein, this connection can be wired connection, it is also possible to be wireless connections.
Owing to the speed of fluid ejection is the fastest, it is the biggest to the pressure of the sidewall in hole 201, based on this principle, the embodiment of the present invention detects the fluid force value to the sidewall in hole by arranging the first pressure transducer on the sidewall in hole, control unit is when the force value that the first pressure transducer examined detects is more than the first predetermined threshold value, send control signal, increase with the aperture of the magnitude of voltage control hole by regulating the first piezo-activator, so that in the case of the solution of ejection same volume, the speed of ejection is reduced, the solution speed of the injection device ejection solving instrument for extracting nucleic acid of the prior art causes solution to spill soon, and then affect the technical problem of nucleic acid extraction process, the situation avoiding solution splash occurs.
As a kind of preferred implementation, as shown in Figure 2, the injection device of the embodiment of the present invention also includes: the second piezo-activator 40, and this second piezo-activator 40 is positioned on the tube wall of fluid line 10, the pipe diameter size of the control signal regulated fluid pipeline 10 for sending according to control unit.Second piezo-activator 40 is wired with control unit or wireless connections, can deform upon along f3 direction thus the pipe diameter size of regulated fluid pipeline 10, and it can also be multiple that the second piezo-activator 40 can be one.
The discharge of the impacts such as the toughness due to solution and solution controls, the embodiment of the present invention carrys out the pipe diameter size of regulated fluid pipeline by arranging the second piezo-activator, so, user can pre-set the pipe diameter size adjusting fluid line as required, it is also possible to is regulated in real time by control unit according to factors such as the fluid flows in fluid line.
As a kind of preferred implementation, as in figure 2 it is shown, injection device also includes: the second pressure transducer 50, this second pressure transducer 50 is arranged on the inner tubal wall of fluid line 10, it is connected with control unit, for detecting the pressure of the inner tubal wall of fluid convection body pipeline 10；Wherein, control unit is additionally operable to the pipe diameter size of pressure size adjustment fluid line of the inner tubal wall according to fluid convection body pipeline.
The embodiment of the present invention, the inner tubal wall pressure of fluid convection body pipeline is detected by increasing by the second pressure transducer, make when the excessive velocities that fluid sprays from hole, the control of fluid spouting velocity can be realized by the pipe diameter size of regulated fluid pipeline, avoid the situation of solution splash to occur further.
Alternatively, during the present invention implements, first pressure transducer is multiple, wherein, control unit is additionally operable to calculate the meansigma methods of multiple force value corresponding to pressure signal that multiple first pressure transducer detects, and by judging whether meansigma methods reaches the first predetermined threshold value and judge that the fluid force value to the sidewall in hole is more than the first predetermined threshold value.
In the present embodiment, detect the fluid lateral wall pressure to hole by arranging multiple first pressure transducer, it is ensured that the accuracy of testing result, thus realize accurately controlling.
Instrument for extracting nucleic acid includes micropump, for to pipeline for fluids drawing fluid, alternatively, the control unit of the embodiment of the present invention is additionally operable to reduce the rotating speed of micropump when the fluid that the first pressure transducer detects reaches the second predetermined threshold value to the force value of the sidewall in hole.
In the present embodiment, when fluid reaches the second predetermined threshold value to the force value of the sidewall in hole, show that the flow velocity of this fluid is too fast, the purpose of regulation cannot have been realized by the size of adjustment aperture, therefore, control the pump speeds of fluid by controlling the rotating speed of micropump, and then realize the regulation of fluid velocity, avoid the situation of solution splash to occur further.
Embodiment 2
Originally executing example and provide a kind of injection device control method for instrument for extracting nucleic acid, the method can have the control unit in the embodiment of the present invention to perform.As it is shown on figure 3, the method includes:
Step S301, receives the pressure signal that the first pressure transducer detects, wherein, the first pressure transducer is the force value for detecting when fluid flows out the sidewall to hole from the hole of injection device.
Step S302, it is judged that whether the force value that pressure signal is corresponding reaches the first predetermined threshold value.
Step S303, when judging that force value reaches the first predetermined threshold value, sends control signal, increases with the aperture of the magnitude of voltage control hole by regulating the first piezo-activator, and wherein, the middle part of the first piezo-activator has the hole passed through for fluid.When force value is not up to the first predetermined threshold value, can return and re-start and pressure detecting, or not be controlled regulation.
It should be noted that the first pressure transducer described in the present embodiment, the first piezo-activator etc. are the parts that in above-described embodiment 1, injection device is had, referring specifically to above-described embodiment 1, repeat no more here.
In the present embodiment, after first pressure transducer detects pressure signal, transmitted this control unit, control unit judges whether corresponding force value reaches the first predetermined threshold value, and when it reaches the first predetermined threshold value, control signal is sent to the first piezo-activator, to control voltage thereon, it is made to deform upon to the direction of hole diameter enlargement, so, the aperture of the magnitude of voltage control hole regulating the first piezo-activator increases, so that in the case of the solution of ejection same volume, the speed of ejection is reduced, the solution speed of the injection device ejection solving instrument for extracting nucleic acid of the prior art causes solution to spill soon, and then affect the technical problem of nucleic acid extraction process, the situation avoiding solution splash occurs.
In the case of the first pressure transducer is multiple, as a kind of preferred implementation, it is judged that whether the force value that pressure signal is corresponding reaches the first predetermined threshold value includes:
S11, calculates the meansigma methods of multiple force value corresponding to pressure signal that multiple first pressure transducer detects；
S12, it is judged that whether meansigma methods reaches the first predetermined threshold value.Wherein, when judging that the first meansigma methods reaches the first predetermined threshold value, send control signal, increase with the aperture of the magnitude of voltage control hole by regulating the first piezo-activator.
In the present embodiment, detect the fluid lateral wall pressure to hole by arranging multiple first pressure transducer, it is ensured that the accuracy of testing result, thus realize accurately controlling.
As a kind of preferred implementation, the embodiment of the present invention is after judging that force value reaches the first predetermined threshold value, and method also includes:
S21, it is judged that whether force value reaches the second predetermined threshold value, and wherein, the second predetermined threshold value is more than the first predetermined threshold value；
S22, when judging that force value reaches the second predetermined threshold value, reduces the rotating speed of the micropump of instrument for extracting nucleic acid.
In the present embodiment, when fluid reaches the second predetermined threshold value to the force value of the sidewall in hole, show that the flow velocity of this fluid is too fast, the purpose of regulation cannot have been realized by the size of adjustment aperture, therefore, control the pump speeds of fluid by controlling the rotating speed of micropump, and then realize the regulation of fluid velocity, avoid the situation of solution splash to occur further.
Embodiment 3
The embodiment of the present invention additionally provides a kind of instrument for extracting nucleic acid, including: the injection device that above-described embodiment 1 is provided.
Obviously, above-described embodiment is only for clearly demonstrating example, and not restriction to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here without also cannot all of embodiment be given exhaustive.And the obvious change thus extended out or variation still in the protection domain of the invention among.
Claims (10)
1. the injection device for instrument for extracting nucleic acid, it is characterised in that including:
Fluid line, its one end is connected with pipeline for fluids；
First piezo-activator, is connected with the other end of described fluid line, and the middle part of described first piezo-activator has the hole passed through for fluid, and the fluid flowing into described fluid line from described pipeline for fluids flows out from described hole；
First pressure transducer, is arranged on the sidewall in described hole, for detecting when fluid flows out the force value of the sidewall to described hole from described hole；
Control unit, the described fluid for detecting according to described first pressure transducer sends control signal when the force value of the sidewall in described hole is more than the first predetermined threshold value, to control the aperture increase in described hole by regulating the magnitude of voltage of the first piezo-activator.
Injection device the most according to claim 1, it is characterised in that described injection device also includes:
Second piezo-activator, is positioned on the tube wall of described fluid line, and the described control signal for sending according to described control unit regulates the pipe diameter size of described fluid line.
Injection device the most according to claim 1, it is characterised in that described injection device also includes:
Second pressure transducer, is arranged on the inner tubal wall of described fluid line, is connected with described control unit, for detecting the described fluid pressure to the inner tubal wall of described fluid line；
Wherein, described control unit is additionally operable to according to the described fluid pipe diameter size to fluid line described in the pressure size adjustment of the inner tubal wall of described fluid line.
Injection device the most according to claim 1, it is characterised in that described control unit is respectively connected with described first piezo-activator and described first pressure transducer.
Injection device the most according to claim 1, it is characterized in that, described first pressure transducer is multiple, wherein, described control unit is additionally operable to calculate the meansigma methods of multiple force value corresponding to pressure signal that multiple described first pressure transducer detects, and by judging whether described meansigma methods reaches described first predetermined threshold value and judge that the described fluid force value to the sidewall in described hole is more than described first predetermined threshold value.
Injection device the most according to claim 1, it is characterized in that, described instrument for extracting nucleic acid includes micropump, for pumping described fluid to described pipeline for fluids, described control unit is additionally operable to reduce the rotating speed of described micropump when the described fluid that described first pressure transducer detects reaches the second predetermined threshold value to the force value of the sidewall in described hole.
7. the injection device control method for instrument for extracting nucleic acid, it is characterised in that including:
Receiving the pressure signal that the first pressure transducer detects, wherein, described first pressure transducer is the force value for detecting when fluid flows out the sidewall to described hole from the hole of injection device；
Judge whether the force value that described pressure signal is corresponding reaches the first predetermined threshold value；
When judging that described force value reaches described first predetermined threshold value, send control signal, to control the aperture increase in described hole by regulating the magnitude of voltage of the first piezo-activator, wherein, the middle part of described first piezo-activator has the described hole passed through for described fluid.
Method the most according to claim 7, it is characterised in that described first pressure transducer is multiple, whether the described force value judging that described pressure signal is corresponding reaches the first predetermined threshold value includes:
Calculate the meansigma methods of multiple force value corresponding to pressure signal that multiple described first pressure transducer detects；
Judge whether described meansigma methods reaches the first predetermined threshold value.
Method the most according to claim 7, it is characterised in that after judging that described force value reaches described first predetermined threshold value, described method also includes:
Judging whether described force value reaches the second predetermined threshold value, wherein, described second predetermined threshold value is more than described first predetermined threshold value；
When judging that described force value reaches described second predetermined threshold value, reduce the rotating speed of the micropump of instrument for extracting nucleic acid.
10. an instrument for extracting nucleic acid, it is characterised in that including: the injection device according to any one of claim 1 to 6.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610292130.6A CN105820949B (en) | 2016-05-05 | 2016-05-05 | A kind of instrument for extracting nucleic acid and its injection device and injection device control method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610292130.6A CN105820949B (en) | 2016-05-05 | 2016-05-05 | A kind of instrument for extracting nucleic acid and its injection device and injection device control method |
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| CN105820949A true CN105820949A (en) | 2016-08-03 |
| CN105820949B CN105820949B (en) | 2018-05-18 |
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| US20050072216A1 (en) * | 2003-08-08 | 2005-04-07 | Engel Thomas W. | Piezocable based sensor for measuring unsteady pressures inside a pipe |
| CN101029652A (en) * | 2006-03-02 | 2007-09-05 | Smc株式会社 | Flow rate control apparatus |
| KR20110056867A (en) * | 2009-11-23 | 2011-05-31 | 삼성전자주식회사 | Tube type piezoelectric energy generating device and method for manufacturing the same |
| CN103592979A (en) * | 2012-08-15 | 2014-02-19 | 盛美半导体设备（上海）有限公司 | Cleaning fluid flow control system and cleaning fluid flow control method |
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2016
- 2016-05-05 CN CN201610292130.6A patent/CN105820949B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050072216A1 (en) * | 2003-08-08 | 2005-04-07 | Engel Thomas W. | Piezocable based sensor for measuring unsteady pressures inside a pipe |
| CN101029652A (en) * | 2006-03-02 | 2007-09-05 | Smc株式会社 | Flow rate control apparatus |
| KR20110056867A (en) * | 2009-11-23 | 2011-05-31 | 삼성전자주식회사 | Tube type piezoelectric energy generating device and method for manufacturing the same |
| CN103592979A (en) * | 2012-08-15 | 2014-02-19 | 盛美半导体设备（上海）有限公司 | Cleaning fluid flow control system and cleaning fluid flow control method |
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