CN105820949B - A kind of instrument for extracting nucleic acid and its injection device and injection device control method - Google Patents
A kind of instrument for extracting nucleic acid and its injection device and injection device control method Download PDFInfo
- Publication number
- CN105820949B CN105820949B CN201610292130.6A CN201610292130A CN105820949B CN 105820949 B CN105820949 B CN 105820949B CN 201610292130 A CN201610292130 A CN 201610292130A CN 105820949 B CN105820949 B CN 105820949B
- Authority
- CN
- China
- Prior art keywords
- pressure
- hole
- fluid
- injection device
- predetermined threshold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a kind of instrument for extracting nucleic acid and its injection device and injection device control method, wherein, injection device includes：Fluid line, its one end are connected with pipeline for fluids；First piezoelectric actuator is connected with the other end of fluid line, the middle part of the first piezoelectric actuator have for fluid by hole, flowed out from the fluid of pipeline for fluids incoming fluid pipeline from hole；First pressure sensor, is arranged on the side wall in hole, for detecting the pressure value of the side wall of device to hole when fluid is flowed out from hole；Control unit sends control signal, with the aperture increases of the voltage value control hole by adjusting the first piezoelectric actuator when being more than the first predetermined threshold value for the pressure value of the side wall of the fluid device to hole detected according to first pressure sensor.The solution speed that the injection device that the present invention solves instrument for extracting nucleic acid of the prior art sprays causes solution to spill soon, and then the technical issues of influence nucleic acid extraction process, avoids happening for solution splash.
Description
Technical field
The present invention relates to nucleic acid extraction fields, and in particular to a kind of instrument for extracting nucleic acid and its injection device and injection device control
Method processed.
Background technology
Instrument for extracting nucleic acid is the instrument that the extraction work of sample nucleic acid is automatically performed using mating nucleic acid extracting reagent
Device, instrument for extracting nucleic acid are divided into two classes：One kind is large-scale automation, commonly referred to as automated fluid work station；Another kind of is small
The automatic instrument for extracting nucleic acid of type is automatically performed extraction purification process using packaged matched reagent.Large-scale automated fluid work station
Because equipment cost is high, operating cost is high, is suitble to once extract thousands of a one species samples, so be really applied
It is fewer；And the instrument of small automatic, it is easy to operate because instrument and equipment and operating cost are low, it has obtained more and more
Using.
Such as the gloomy longevity expands to wait in the method for extracting nucleic acid of propositions and nucleic acid-extracting apparatus (CN101886037A) and discloses one
Kind nucleic acid-extracting apparatus, belongs to the instrument of small automatic, the sample solution containing nucleic acid is handled using the nucleic acid-extracting apparatus,
There is efficient, easy, quick, good automation adaptability and good repeatability.The device passes through the first dispensing
Cleaning solution is dispensed into multiple nucleic acid extraction columns through arrangement by mouth, by second dispensing mouth by recovered liquid be dispensed into it is multiple through row
In the nucleic acid extraction column of cloth.However, in the program when blocking occurs in dispensing mouth or liquid inventory is excessive so that from dispensing mouth
The solution speed of ejection is too fast, is easy to cause the solution being injected into extraction column and spills, and then influences nucleic acid extraction process.
The content of the invention
Therefore, the technical problem to be solved in the present invention is what the injection device of instrument for extracting nucleic acid of the prior art sprayed
Solution speed causes solution to spill soon, and then influences nucleic acid extraction process.
According to an aspect of the present invention, a kind of injection device for instrument for extracting nucleic acid is provided, including：Fluid line,
Its one end is connected with pipeline for fluids；First piezoelectric actuator is connected with the other end of the fluid line, first pressure
The middle part of electric actuator have for fluid by hole, flow into the fluid of the fluid line from institute from the pipeline for fluids
State hole outflow；First pressure sensor is arranged on the side wall in the hole, for detecting when fluid is flowed out from the hole to described
The pressure value of the side wall in hole；Control unit, for the fluid that is detected according to the first pressure sensor to the hole
Side wall pressure value be more than the first predetermined threshold value when send control signal, with pass through adjust the first piezoelectric actuator voltage value
Control the aperture increases in the hole.
Preferably, the injection device further includes：Second piezoelectric actuator on the tube wall of the fluid line, is used
The pipe diameter size of the fluid line is adjusted in the control signal sent according to described control unit.
Preferably, the injection device further includes：Second pressure sensor is arranged on the inner tubal wall of the fluid line
On, it is connected with described control unit, for detecting pressure of the fluid to the inner tubal wall of the fluid line；Wherein, institute
Control unit is stated to be additionally operable to adjust the fluid line to the pressure size of the inner tubal wall of the fluid line according to the fluid
Pipe diameter size.
Preferably, described control unit is respectively connected with first piezoelectric actuator and the first pressure sensor
It connects.
Preferably, the first pressure sensor is multiple, wherein, described control unit is additionally operable to calculate multiple described the
The average value for the corresponding multiple pressure values of pressure signal that one pressure sensor detects, and pass through and whether judge the average value
Reach first predetermined threshold value to judge that the fluid is more than first predetermined threshold value to the pressure value of the side wall in the hole.
Preferably, the instrument for extracting nucleic acid includes micropump, for pumping the fluid, institute to the pipeline for fluids
Control unit is stated to be additionally operable to reach the pressure value of the side wall in the hole in the fluid that the first pressure sensor detects
The rotating speed of the micropump is reduced during to the second predetermined threshold value.
According to another aspect of the present invention, a kind of injection device control method for instrument for extracting nucleic acid is additionally provided,
Including：The pressure signal that first pressure sensor detects is received, wherein, the first pressure sensor is for detecting fluid
To the pressure value of the side wall in the hole when being flowed out from the hole of injection device；Judge whether the pressure signal corresponding pressure value reaches
To the first predetermined threshold value；When judging that the pressure value reaches first predetermined threshold value, control signal is sent, is adjusted with passing through
The voltage value for saving the first piezoelectric actuator controls the aperture increases in the hole, wherein, the middle part tool of first piezoelectric actuator
Have for the fluid by the hole.
Preferably, the first pressure sensor is described whether to judge the pressure signal corresponding pressure value to be multiple
Reaching the first predetermined threshold value includes：Calculate the corresponding multiple pressure of pressure signal that multiple first pressure sensors detect
The average value of value；Judge whether the average value reaches the first predetermined threshold value.
Preferably, after judging that the pressure value reaches first predetermined threshold value, the method further includes：Judge
Whether the pressure value reaches the second predetermined threshold value, wherein, second predetermined threshold value is more than first predetermined threshold value；Sentencing
Break when the pressure value and reaching second predetermined threshold value, reduce the rotating speed of the micropump of instrument for extracting nucleic acid.
According to another aspect of the present invention, a kind of instrument for extracting nucleic acid is additionally provided, which is characterized in that including：Above-mentioned
Injection device.
The embodiment of the present invention detects the side wall of fluid device to hole by setting first pressure sensor on the side wall in hole
Pressure value, control unit send control when the pressure value that the first pressure sensor examined detects is more than the first predetermined threshold value
Signal processed, with the aperture increases of the voltage value control hole by adjusting the first piezoelectric actuator, so that spraying same volume
In the case of long-pending solution, the speed of ejection is reduced, and solves the injection device spray of instrument for extracting nucleic acid of the prior art
The solution speed gone out causes solution to spill soon, and then the technical issues of influence nucleic acid extraction process, avoids the situation of solution splash
Occur.
Description of the drawings
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution of the prior art
Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, in describing below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, can also be obtained according to these attached drawings other attached drawings.
Fig. 1 is the axial sectional view of the flow controllable nozzles for nucleic acid automatic extracting instrument in the embodiment of the present invention 1；
Fig. 2 is the flow controllable nozzles for nucleic acid automatic extracting instrument of another specific example in the embodiment of the present invention 1
Top view；
Fig. 3 is the flow chart of the injection device control method for instrument for extracting nucleic acid in the embodiment of the present invention 2.
Reference numeral：10- fluid lines, the first piezoelectric actuators of 20-, 30- first pressure sensors, the second piezoelectricity of 40-
Actuator, 50- second pressure sensors, 201- holes, f1, f2, f3- deformation direction.
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's all other embodiments obtained without making creative work, belong to the scope of protection of the invention.
In the description of the present invention, it is necessary to explanation, term " " center ", " on ", " under ", "left", "right", " vertical ",
The orientation or position relationship of the instructions such as " level ", " interior ", " outer " be based on orientation shown in the drawings or position relationship, merely to
Convenient for the description present invention and simplify description rather than instruction or imply signified device or element must have specific orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.In addition, term " first ", " second ",
" the 3rd " is only used for description purpose, and it is not intended that instruction or hint relative importance.
In the description of the present invention, it is necessary to illustrate, unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected or be integrally connected；It can
To be mechanical connection or be electrically connected；It can be directly connected, can also be indirectly connected by intermediary, it can be with
It is the connection inside two elements, can is wireless connection or wired connection.For those of ordinary skill in the art
For, the concrete meaning of above-mentioned term in the present invention can be understood with concrete condition.
As long as in addition, technical characteristic involved in invention described below different embodiments non-structure each other
It can be combined with each other into conflict.
Embodiment 1
An embodiment of the present invention provides a kind of injection device for instrument for extracting nucleic acid, as shown in Figure 1, the device includes：
Fluid line 10, the first piezoelectric actuator 20, first pressure sensor 30 and control unit (not shown).
10 its one end of fluid line is connected with pipeline for fluids.Wherein, pipeline for fluids is used to note to injection device
Enter fluid, which can be for extracting the sample solution of nucleic acid or cleaning solution etc..
The other end of fluid line 10 is connected with the first piezoelectric actuator 20, wherein, the middle part of the first piezoelectric actuator 20
With for fluid by hole 201, flow out that (fluid is along f1 from the fluid of pipeline for fluids incoming fluid pipeline 10 from hole 201
It flows in direction).First piezoelectric actuator 20 can be deformed upon in the control of control unit to along f2 directions, so as to change hole
201 pore size.
First pressure sensor 30 is arranged on the side wall in hole 201, for detecting the side wall of device to hole when fluid is flowed out from hole
Pressure value.
The pressure value that control unit is used for the side wall of the fluid device to hole 201 detected according to first pressure sensor 30 is more than
Control signal is sent during the first predetermined threshold value, with the aperture of the voltage value control hole 201 by adjusting the first piezoelectric actuator 20
Increase.Preferably, control unit is respectively connected with the first piezoelectric actuator 20 and first pressure sensor 30 and (does not show in figure
Go out), wherein, which can be wired connection or wireless connection.
Since the speed that fluid sprays is faster, the pressure of the side wall of device to hole 201 is bigger, and based on the principle, the present invention is real
Example is applied by setting first pressure sensor on the side wall in hole to detect the pressure value of the side wall of fluid device to hole, control unit exists
When the pressure value that the first pressure sensor examined detects is more than the first predetermined threshold value, control signal is sent, is adjusted with passing through
The aperture increases of the voltage value control hole of first piezoelectric actuator, so that in the case where spraying the solution of same volume,
The speed of ejection is reduced, and the solution speed for solving the injection device ejection of instrument for extracting nucleic acid of the prior art causes soon
Solution is spilt, and then the technical issues of influence nucleic acid extraction process, avoids happening for solution splash.
As a kind of preferred embodiment, as shown in Fig. 2, the injection device of the embodiment of the present invention further includes：Second piezoelectricity
Actuator 40, which is located on the tube wall of fluid line 10, for the control sent according to control unit
The pipe diameter size of Signal Regulation fluid line 10.Second piezoelectric actuator 40 and control unit be wired or wireless connection, can be with
Deform upon to adjust the pipe diameter size of fluid line 10 along f3 directions, the second piezoelectric actuator 40 can be one can also
It is multiple.
The discharge of the influences such as the toughness due to solution and solution controls, and the embodiment of the present invention is by setting the second pressure
Electric actuator adjusts the pipe diameter size of fluid line, in this way, user can pre-set adjustment fluid line as needed
Pipe diameter size can also in real time be adjusted according to factors such as the fluid flows in fluid line by control unit.
As a kind of preferred embodiment, as shown in Fig. 2, injection device further includes：Second pressure sensor 50, this second
Pressure sensor 50 is arranged on the inner tubal wall of fluid line 10, is connected with control unit, for detecting fluid fluid pipe
The pressure of the inner tubal wall in road 10；Wherein, control unit is additionally operable to the pressure size tune of the inner tubal wall according to fluid convection body pipeline
Save the pipe diameter size of fluid line.
The embodiment of the present invention detects the inner tubal wall pressure in fluid fluid pipe road by increasing second pressure sensor,
So that in the excessive velocities that fluid is sprayed from hole, it can realize that fluid sprays speed by adjusting the pipe diameter size of fluid line
The control of degree further avoids happening for solution splash.
Optionally, during the present invention is implemented, first pressure sensor is multiple, wherein, control unit is additionally operable to calculate multiple
The average value for the corresponding multiple pressure values of pressure signal that first pressure sensor detects, and pass through and judge whether average value reaches
Judge that the pressure value of the side wall of fluid device to hole is more than the first predetermined threshold value to the first predetermined threshold value.
In the present embodiment, by the way that multiple first pressure sensors is set to detect the lateral wall pressure of fluid device to hole, it ensure that
The accuracy of testing result, so as to fulfill accurate control.
Instrument for extracting nucleic acid includes micropump, for pipeline for fluids drawing fluid, optionally, the embodiment of the present invention
The pressure value that control unit is additionally operable to the side wall of the fluid device to hole detected in first pressure sensor reaches the second predetermined threshold value
When reduce micropump rotating speed.
In the present embodiment, when the pressure value of the side wall of fluid device to hole reaches the second predetermined threshold value, show the stream of the fluid
Speed is too fast, can not realize the purpose of adjusting by the size of adjustment aperture, therefore, controlled by controlling the rotating speed of micropump
The pump speeds of fluid processed, and then realize the adjusting of fluid velocity, further avoid happening for solution splash.
Embodiment 2
Originally apply example and a kind of injection device control method for instrument for extracting nucleic acid is provided, this method there can be implementation of the present invention
Control unit in example performs.As shown in figure 3, this method includes：
Step S301 receives the pressure signal that detects of first pressure sensor, wherein, first pressure sensor be for
The pressure value of the side wall of device to hole when detection fluid is flowed out from the hole of injection device.
Step S302, judges whether pressure signal corresponding pressure value reaches the first predetermined threshold value.
Step S303 when judging that pressure value reaches the first predetermined threshold value, sends control signal, with by adjusting first
The aperture increases of the voltage value control hole of piezoelectric actuator, wherein, the middle part of the first piezoelectric actuator have for fluid by
Hole.When pressure value is not up to the first predetermined threshold value, can return re-start and pressure detecting or without control adjust
Section.
It should be noted that first pressure sensor, the first piezoelectric actuator described in the present embodiment etc. is above-mentioned
Component possessed by injection device in embodiment 1, referring specifically to above-described embodiment 1, which is not described herein again.
In the present embodiment, after first pressure sensor detects pressure signal, the control unit, control unit are transmitted
Judge whether corresponding pressure value reaches the first predetermined threshold value, and when it reaches the first predetermined threshold value, it is piezoelectric actuated to first
Device sends control signal, to control voltage thereon, it is made to be deformed upon to the direction of hole diameter enlargement, in this way, adjusting the first pressure
The aperture increases of the voltage value control hole of electric actuator, so that in the case where spraying the solution of same volume, ejection
Speed is reduced, and the solution speed for solving the injection device ejection of instrument for extracting nucleic acid of the prior art causes solution to splash soon
The technical issues of going out, and then influencing nucleic acid extraction process, avoids happening for solution splash.
In the case where first pressure sensor is multiple, as a kind of preferred embodiment, judge that pressure signal corresponds to
Pressure value whether reach the first predetermined threshold value and include：
S11 calculates the average value for the corresponding multiple pressure values of pressure signal that multiple first pressure sensors detect；
S12, judges whether average value reaches the first predetermined threshold value.Wherein, judging that it is pre- that the first average value reaches first
If during threshold value, sending control signal, with the aperture increases of the voltage value control hole by adjusting the first piezoelectric actuator.
In the present embodiment, by the way that multiple first pressure sensors is set to detect the lateral wall pressure of fluid device to hole, it ensure that
The accuracy of testing result, so as to fulfill accurate control.
As a kind of preferred embodiment, the embodiment of the present invention after judging that pressure value reaches the first predetermined threshold value,
Method further includes：
S21, judges whether pressure value reaches the second predetermined threshold value, wherein, the second predetermined threshold value is more than the first predetermined threshold value；
S22 when judging that pressure value reaches the second predetermined threshold value, reduces the rotating speed of the micropump of instrument for extracting nucleic acid.
In the present embodiment, when the pressure value of the side wall of fluid device to hole reaches the second predetermined threshold value, show the stream of the fluid
Speed is too fast, can not realize the purpose of adjusting by the size of adjustment aperture, therefore, controlled by controlling the rotating speed of micropump
The pump speeds of fluid processed, and then realize the adjusting of fluid velocity, further avoid happening for solution splash.
Embodiment 3
The embodiment of the present invention additionally provides a kind of instrument for extracting nucleic acid, including：The injection device that above-described embodiment 1 is provided.
Obviously, the above embodiments are merely examples for clarifying the description, and is not intended to limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And the obvious variation thus extended out or
Among changing still in the protection domain of the invention.
Claims (7)
1. a kind of injection device for instrument for extracting nucleic acid, which is characterized in that including：
Fluid line, its one end are connected with pipeline for fluids；
First piezoelectric actuator is connected with the other end of the fluid line, and the middle part of first piezoelectric actuator, which has, to be supplied
Fluid by hole, the fluid that the fluid line is flowed into from the pipeline for fluids flows out from the hole；
First pressure sensor is arranged on the side wall in the hole, for detecting when fluid is flowed out from the hole to the hole
The pressure value of side wall；
Control unit, for the pressure value according to the fluid that the first pressure sensor detects to the side wall in the hole
Control signal is sent during more than the first predetermined threshold value, to control the hole in the hole by adjusting the voltage value of the first piezoelectric actuator
Footpath increases；
Wherein, the injection device further includes：
Second piezoelectric actuator, on the tube wall of the fluid line, for the control sent according to described control unit
The pipe diameter size of fluid line described in Signal Regulation processed；
Wherein, the injection device further includes：Second pressure sensor is arranged on the inner tubal wall of the fluid line, with institute
It states control unit to be connected, for detecting pressure of the fluid to the inner tubal wall of the fluid line；
Wherein, described control unit is additionally operable to adjust institute to the pressure size of the inner tubal wall of the fluid line according to the fluid
State the pipe diameter size of fluid line.
2. injection device according to claim 1, which is characterized in that described control unit and first piezoelectric actuator
It is respectively connected with the first pressure sensor.
3. injection device according to claim 1, which is characterized in that the first pressure sensor is multiple, wherein, institute
Control unit is stated to be additionally operable to calculate the corresponding multiple pressure values of pressure signal that multiple first pressure sensors detect
Average value, and judge side of the fluid to the hole by judging whether the average value reaches first predetermined threshold value
The pressure value of wall is more than first predetermined threshold value.
4. injection device according to claim 1, which is characterized in that the instrument for extracting nucleic acid include micropump, for
The pipeline for fluids pumps the fluid, and described control unit is additionally operable to the institute detected in the first pressure sensor
Stating reduces the rotating speed of the micropump when fluid reaches the second predetermined threshold value to the pressure value of the side wall in the hole.
5. a kind of injection device control method for instrument for extracting nucleic acid, which is characterized in that including：
The pressure signal that first pressure sensor detects is received, wherein, the first pressure sensor is for detecting fluid
To the pressure value of the side wall in the hole when being flowed out from the hole of injection device；
Judge whether the pressure signal corresponding pressure value reaches the first predetermined threshold value；
When judging that the pressure value reaches first predetermined threshold value, control signal is sent, with by adjusting the first piezoelectricity
The voltage value of actuator controls the aperture increases in the hole, wherein, the middle part of first piezoelectric actuator, which has, supplies the stream
Body by the hole；
After judging that the pressure value reaches first predetermined threshold value, the method further includes：
Judge whether the pressure value reaches the second predetermined threshold value, wherein, it is default that second predetermined threshold value is more than described first
Threshold value；
When judging that the pressure value reaches second predetermined threshold value, the rotating speed of the micropump of instrument for extracting nucleic acid is reduced.
6. according to the method described in claim 5, it is characterized in that, the first pressure sensor is multiple, the judgement institute
Stating pressure signal corresponding pressure value and whether reaching the first predetermined threshold value includes：
Calculate the average value for the corresponding multiple pressure values of pressure signal that multiple first pressure sensors detect；Judge institute
State whether average value reaches the first predetermined threshold value.
7. a kind of instrument for extracting nucleic acid, which is characterized in that including：Injection device any one of Claims 1-4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610292130.6A CN105820949B (en) | 2016-05-05 | 2016-05-05 | A kind of instrument for extracting nucleic acid and its injection device and injection device control method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610292130.6A CN105820949B (en) | 2016-05-05 | 2016-05-05 | A kind of instrument for extracting nucleic acid and its injection device and injection device control method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105820949A CN105820949A (en) | 2016-08-03 |
| CN105820949B true CN105820949B (en) | 2018-05-18 |
Family
ID=56528292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610292130.6A Active CN105820949B (en) | 2016-05-05 | 2016-05-05 | A kind of instrument for extracting nucleic acid and its injection device and injection device control method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105820949B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101029652A (en) * | 2006-03-02 | 2007-09-05 | Smc株式会社 | Flow rate control apparatus |
| KR20110056867A (en) * | 2009-11-23 | 2011-05-31 | 삼성전자주식회사 | Tube type piezoelectric energy generating device and method for manufacturing the same |
| CN103592979A (en) * | 2012-08-15 | 2014-02-19 | 盛美半导体设备（上海）有限公司 | Cleaning fluid flow control system and cleaning fluid flow control method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7308820B2 (en) * | 2003-08-08 | 2007-12-18 | Cidra Corporation | Piezocable based sensor for measuring unsteady pressures inside a pipe |
-
2016
- 2016-05-05 CN CN201610292130.6A patent/CN105820949B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101029652A (en) * | 2006-03-02 | 2007-09-05 | Smc株式会社 | Flow rate control apparatus |
| KR20110056867A (en) * | 2009-11-23 | 2011-05-31 | 삼성전자주식회사 | Tube type piezoelectric energy generating device and method for manufacturing the same |
| CN103592979A (en) * | 2012-08-15 | 2014-02-19 | 盛美半导体设备（上海）有限公司 | Cleaning fluid flow control system and cleaning fluid flow control method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105820949A (en) | 2016-08-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI664350B (en) | Multiple stage pump and pumping system | |
| CN110226091B (en) | Automatic analysis device | |
| WO2017049375A1 (en) | Mixing ring for dissolving a portion of solute in a portion of solvent, system and method for dissolve a portion of solute in a portion of solvent | |
| JP2020514015A5 (en) | ||
| CN105820949B (en) | A kind of instrument for extracting nucleic acid and its injection device and injection device control method | |
| WO2007117321B1 (en) | Syringe wash station for analytical applications | |
| CN104500777B (en) | A kind of electromagnetic clamp pipe valve applied in ultrasonic clear stone equipment | |
| US20230123459A1 (en) | Liquid chromatographic apparatus and air bubble removal method of liquid chromatographic apparatus | |
| CN108700560B (en) | Chromatograph device | |
| CN107893793B (en) | Cylinder operation condition monitoring device | |
| JP4615925B2 (en) | Microfluidic device | |
| US10906797B2 (en) | Suction filler spout | |
| AU2015359241B2 (en) | A dispenser device and a method for rinsing the dispenser device | |
| CN105642455B (en) | Flow controllable nozzles and nucleic acid automatic extracting instrument for nucleic acid automatic extracting instrument | |
| US20220228897A1 (en) | Dosing unit and method for dosing a liquid | |
| EP3425368B1 (en) | Obtaining product sample from a vacuum vessel | |
| SU1276257A3 (en) | Device for pouring out liquid | |
| JP2004121884A (en) | Interface position-adjustable liquid separating tank | |
| CN110073197B (en) | Particle counting device | |
| CN206871621U (en) | accurate liquid taking device | |
| CN203807461U (en) | Buffer and perfusion system | |
| JP6057754B2 (en) | Automatic clinical analyzer and method | |
| CN116851323A (en) | Hydraulic component cleaning method and hydraulic component cleaning system | |
| US12115951B2 (en) | Liquid ejection device for a vehicle washing system and method for its operation | |
| JP5529671B2 (en) | Microfluidic device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |