CN105642455B - Flow controllable nozzles and nucleic acid automatic extracting instrument for nucleic acid automatic extracting instrument - Google Patents
Flow controllable nozzles and nucleic acid automatic extracting instrument for nucleic acid automatic extracting instrument Download PDFInfo
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- CN105642455B CN105642455B CN201610136423.5A CN201610136423A CN105642455B CN 105642455 B CN105642455 B CN 105642455B CN 201610136423 A CN201610136423 A CN 201610136423A CN 105642455 B CN105642455 B CN 105642455B
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- piezoelectric actuator
- nucleic acid
- fluid line
- fluid
- automatic extracting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/02—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/30—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
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- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
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- Biotechnology (AREA)
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- Microbiology (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
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Abstract
The invention discloses a kind of flow controllable nozzles and nucleic acid automatic extracting instrument for nucleic acid automatic extracting instrument, and wherein the nozzle includes: fluid line, and one end is connect with pipeline for fluids, and the other end is connect with the first piezoelectric actuator；First piezoelectric actuator, middle part have the hole passed through for fluid, and the fluid for flowing into the fluid line from pipeline for fluids is flowed out from the hole, and the shape in the hole in the middle part of the first piezoelectric actuator can be changed in the case where applying voltage control.The appearance for situations such as flow controllable nozzles for nucleic acid automatic extracting instrument of the invention can be realized the controllable adjustment of the flow of mass flowing nozzle, prevent leakage, dropping liquid.
Description
Technical field
The present invention relates to nucleic acid-extracting apparatus fields, and in particular to a kind of flow for nucleic acid automatic extracting instrument controllably sprays
Mouth and nucleic acid automatic extracting instrument.
Background technique
Instrument for extracting nucleic acid is the instrument that the extraction work of sample nucleic acid is automatically performed using matched nucleic acid extracting reagent
Device, instrument for extracting nucleic acid are divided into two classes: one kind is large-scale automation, commonly referred to as automated fluid work station；Another kind of is small
The automatic instrument for extracting nucleic acid of type is automatically performed extraction purification process using packaged matched reagent.Large-scale automated fluid work station
Because equipment cost is high, operating cost is high, is suitble to once extract thousands of a one species samples, so be really applied
It is fewer；And the instrument of small automatic, it is easy to operate because instrument and equipment and operating cost are low, it has obtained more and more
Using.
Such as one is disclosed in the great method for extracting nucleic acid and nucleic acid-extracting apparatus (CN101886037A) for waiting propositions of gloomy longevity
Kind nucleic acid-extracting apparatus, is belonged to the instrument of small automatic, the sample solution containing nucleic acid is handled using the nucleic acid-extracting apparatus,
Has the advantages that efficient, easy, quick, good automation adaptability and good repeatability.The device passes through the first dispensing
Cleaning solution is dispensed into multiple nucleic acid extraction columns through arranging by mouth, is dispensed into recovered liquid by the second dispensing mouth multiple through arranging
In the nucleic acid extraction column of cloth.But above-mentioned dispensing mouth, when dispensing liquid, dispensing mouth can not be according to the toughness etc. of liquid
Attribute and liquid outflow amount etc. are controlled to adjust, and are led to situations such as there are leakages, dropping liquid, can be polluted surrounding enviroment.
Summary of the invention
Therefore, technical problems to be solved of the embodiment of the present invention are that dispensing mouth in the prior art can not automatically control stream
Amount.
For this purpose, a kind of flow controllable nozzles for nucleic acid automatic extracting instrument of the embodiment of the present invention, comprising:
Fluid line, one end are connect with pipeline for fluids, and the other end is connect with the first piezoelectric actuator；
First piezoelectric actuator, middle part have the hole passed through for fluid, flow into the fluid hose from pipeline for fluids
The fluid in road is flowed out from the hole, and the shape in the hole in the middle part of the first piezoelectric actuator can be changed in the case where applying voltage control
Become.
Preferably, the shape in the hole is round or oval.
Preferably, the shape of first piezoelectric actuator is disc-shaped.
Preferably, further includes:
At least one second piezoelectric actuator, on the tube wall of the fluid line, in the case where applying voltage control
Change the diameter of the fluid line.
Preferably, the number of second piezoelectric actuator is 3-6.
Preferably, second piezoelectric actuator is uniformly distributed on the tube wall of the fluid line.
Preferably, the fluid line is cylindrical or cone；When fluid line is cone, with fluid supply line
The port of one end of the fluid line of road connection is greater than the another of the fluid line connecting with the first piezoelectric actuator
The port at end.
Preferably, the cone angle of the cone is 30 degree of -45 degree.
A kind of nucleic acid automatic extracting instrument of the embodiment of the present invention, including above-mentioned nozzle.
The technical solution of the embodiment of the present invention, has the advantages that
Flow controllable nozzles provided in an embodiment of the present invention for nucleic acid automatic extracting instrument are caused by the first piezoelectricity of setting
Dynamic device keeps the size and shape for flowing out the hole of fluid adjustable, so that the controllable adjustment of the flow of mass flowing nozzle is realized, it can
It is enough according to the demand of the attributes such as the toughness of fluid and practical discharge come the flow of automatic control and adjustment nozzle, prevent leakage,
The appearance of situations such as dropping liquid.
Detailed description of the invention
In order to illustrate more clearly of the technical solution in the specific embodiment of the invention, specific embodiment will be retouched below
Attached drawing needed in stating is briefly described, it should be apparent that, the accompanying drawings in the following description is some realities of the invention
Mode is applied, it for those of ordinary skill in the art, without creative efforts, can also be attached according to these
Figure obtains other attached drawings.
Fig. 1 is the axial section view of the flow controllable nozzles for nucleic acid automatic extracting instrument of a specific example of the invention
Figure；
Fig. 2 is the schematic shapes of the first piezoelectric actuator of a specific example of the invention；
Fig. 3 is the top view of the flow controllable nozzles for nucleic acid automatic extracting instrument of another specific example of the invention；
Fig. 4 is the top view of the flow controllable nozzles for nucleic acid automatic extracting instrument of another specific example of the invention.
Appended drawing reference: 1- fluid line, the first piezoelectric actuator of 2-, the second piezoelectric actuator of 3-, the hole 21-, f1, f2, f3-
Deformation direction.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the orientation or position of the instructions such as term " on ", "lower", "left", "right"
Setting relationship is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of description of the present invention and simplification of the description, rather than
The device or element of indication or suggestion meaning must have a particular orientation, be constructed and operated in a specific orientation, therefore cannot
It is interpreted as limitation of the present invention.Term " first ", " second " etc. are used for description purposes only, and are not understood to indicate or imply
Relative importance.Unless otherwise clearly defined and limited, term " installation ", " connected ", " connection " shall be understood in a broad sense, example
Such as, it may be fixed connection or may be dismantle connection, or integral connection；It can be mechanical connection, be also possible to be electrically connected
It connects；It can be directly connected, can also can also be the connection inside two elements indirectly connected through an intermediary, it can be with
It is to be wirelessly connected, is also possible to wired connection.For the ordinary skill in the art, can be understood with concrete condition above-mentioned
The concrete meaning of term in the present invention.
As long as in addition, the non-structure each other of technical characteristic involved in invention described below different embodiments
It can be combined with each other at conflict.
Embodiment 1
A kind of flow controllable nozzles for nucleic acid automatic extracting instrument are present embodiments provided, as shown in Figure 1, comprising: stream
Body pipeline 1 and the first piezoelectric actuator 2.One end of fluid line 1 is connect with pipeline for fluids, the other end of fluid line 1
It is connect with the first piezoelectric actuator 2.The middle part of first piezoelectric actuator 2 has the hole 21 passed through for fluid, the flowing side of fluid
To for direction f1 as shown in Figure 1, flowed out from the fluid of pipeline for fluids incoming fluid pipeline 1 from hole 21, the first piezoelectricity
The shape in the hole 21 at 2 middle part of actuator can be changed in the case where applying voltage control.First piezoelectric actuator 2 can be using pressure
Electroceramics actuator.
The above-mentioned flow controllable nozzles for nucleic acid automatic extracting instrument make flowing out stream by the way that the first piezoelectric actuator is arranged
The size and shape in the hole of body is adjustable, so that the controllable adjustment of the flow of mass flowing nozzle is realized, it can be according to fluid
Situations such as demand of the attributes such as toughness and practical discharge carrys out the flow of automatic control and adjustment nozzle, prevents leakage, dropping liquid
Occur.
Preferably, the shape in hole 21 is round or oval.Preferably, the shape of the first piezoelectric actuator 2 is disc-shaped.
As shown in Fig. 2, the first piezoelectric actuator 2 is disc-shaped, the shape in hole 21 is circle, when the first piezoelectric actuator 2 is applied electricity
After pressure, the first piezoelectric actuator 2 generates deformation according to deformation direction f2, and direction f2 is along the diameter side of the first piezoelectric actuator 2
To so as to the diameter of adjustment hole 21.
Preferably, as shown in figure 3, being used for the flow controllable nozzles of nucleic acid automatic extracting instrument further include: at least one second
Piezoelectric actuator 3.Second piezoelectric actuator 3 is located on the tube wall of fluid line 1, for changing fluid in the case where applying voltage control
The diameter of pipeline 1.The deformation direction f3 of second piezoelectric actuator 3 is the radial direction along fluid line 1, makes fluid line 1
Diameter becomes larger or becomes smaller.
Preferably, the number of the second piezoelectric actuator 3 is 3-6.Second piezoelectric actuator 3 is uniformly distributed positioned at fluid hose
On the tube wall in road 1.Second piezoelectric actuator 3 can also be distributed entirely around fluid line 1.By changing the straight of fluid line 1
Diameter adjusts the pressure of nozzle, so as to further control the flow of mass flowing nozzle, realizes and automatically controls nozzle flow
Purpose.
Preferably, fluid line 1 is cylindrical or cone；When fluid line 1 is cone, with pipeline for fluids
The port of one end of the fluid line 1 of connection is greater than the end of the other end for the fluid line 1 connecting with the first piezoelectric actuator 2
Mouthful.
Preferably, conical cone angle is 30 degree of -45 degree.
Embodiment 2
The present embodiment provides a kind of nucleic acid automatic extracting instrument, the nozzle including embodiment 1.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (9)
1. a kind of flow controllable nozzles for nucleic acid automatic extracting instrument characterized by comprising
Fluid line (1), one end is connect with pipeline for fluids, and the other end is connect with the first piezoelectric actuator (2)；
First piezoelectric actuator (2), middle part have the hole (21) passed through for fluid, flow into the fluid from pipeline for fluids
The fluid of pipeline (1) is flowed out from the hole (21), and the shape in the hole (21) in the middle part of the first piezoelectric actuator (2) can apply electricity
It is changed under voltage-controlled system.
2. nozzle according to claim 1, which is characterized in that the shape of the hole (21) is round or oval.
3. nozzle according to claim 1 or 2, which is characterized in that the shape of first piezoelectric actuator (2) is disk
Shape.
4. nozzle according to claim 1, which is characterized in that further include:
At least one second piezoelectric actuator (3) is located on the tube wall of the fluid line (1), for applying voltage control
The lower diameter for changing the fluid line (1).
5. nozzle according to claim 4, which is characterized in that the number of second piezoelectric actuator (3) is 3-6.
6. nozzle according to claim 4 or 5, which is characterized in that second piezoelectric actuator (3), which is uniformly distributed, to be located at
On the tube wall of the fluid line (1).
7. nozzle according to claim 1, which is characterized in that the fluid line (1) is cylindrical or cone；Work as stream
When body pipeline (1) is cone, the port of the one end for the fluid line (1) connecting with pipeline for fluids is greater than and first
The port of the other end of the fluid line (1) of piezoelectric actuator (2) connection.
8. nozzle according to claim 7, which is characterized in that the cone angle of the cone is 30 degree of -45 degree.
9. a kind of nucleic acid automatic extracting instrument, which is characterized in that including such as described in any item nozzles of claim 1-8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610136423.5A CN105642455B (en) | 2016-03-10 | 2016-03-10 | Flow controllable nozzles and nucleic acid automatic extracting instrument for nucleic acid automatic extracting instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610136423.5A CN105642455B (en) | 2016-03-10 | 2016-03-10 | Flow controllable nozzles and nucleic acid automatic extracting instrument for nucleic acid automatic extracting instrument |
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| Publication Number | Publication Date |
|---|---|
| CN105642455A CN105642455A (en) | 2016-06-08 |
| CN105642455B true CN105642455B (en) | 2019-06-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610136423.5A Active CN105642455B (en) | 2016-03-10 | 2016-03-10 | Flow controllable nozzles and nucleic acid automatic extracting instrument for nucleic acid automatic extracting instrument |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108117272B (en) * | 2018-01-02 | 2020-12-18 | 京东方科技集团股份有限公司 | Coating nozzle and coating device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103820304A (en) * | 2014-02-25 | 2014-05-28 | 苏州天隆生物科技有限公司 | Microfluid three-dimensional electromagnetic excitation blending device for nucleic acid purification |
| CN104859843A (en) * | 2014-02-21 | 2015-08-26 | 波音公司 | Plasma-assisted Synthetic Jets For Active Air Flow Control |
| CN205392783U (en) * | 2016-03-10 | 2016-07-27 | 苏州百源基因技术有限公司 | A controllable nozzle of flow and nucleic acid automatic withdrawal appearance for nucleic acid automatic withdrawal appearance |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5011012B2 (en) * | 2007-07-18 | 2012-08-29 | 株式会社日立ハイテクノロジーズ | Nucleic acid extraction equipment |
| US9879661B2 (en) * | 2014-08-29 | 2018-01-30 | General Electric Company | Vibrational fluid mover jet with active damping mechanism |
-
2016
- 2016-03-10 CN CN201610136423.5A patent/CN105642455B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104859843A (en) * | 2014-02-21 | 2015-08-26 | 波音公司 | Plasma-assisted Synthetic Jets For Active Air Flow Control |
| CN103820304A (en) * | 2014-02-25 | 2014-05-28 | 苏州天隆生物科技有限公司 | Microfluid three-dimensional electromagnetic excitation blending device for nucleic acid purification |
| CN205392783U (en) * | 2016-03-10 | 2016-07-27 | 苏州百源基因技术有限公司 | A controllable nozzle of flow and nucleic acid automatic withdrawal appearance for nucleic acid automatic withdrawal appearance |
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