CN1058170C - Drug for treating sexual impotence - Google Patents
Drug for treating sexual impotence Download PDFInfo
- Publication number
- CN1058170C CN1058170C CN96109801A CN96109801A CN1058170C CN 1058170 C CN1058170 C CN 1058170C CN 96109801 A CN96109801 A CN 96109801A CN 96109801 A CN96109801 A CN 96109801A CN 1058170 C CN1058170 C CN 1058170C
- Authority
- CN
- China
- Prior art keywords
- parts
- fructus
- radix
- mesh sieves
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 42
- 201000001881 impotence Diseases 0.000 title claims abstract description 18
- 229940079593 drug Drugs 0.000 title claims description 19
- 208000010228 Erectile Dysfunction Diseases 0.000 title claims description 15
- 241000208966 Polygala Species 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 241000237903 Hirudo Species 0.000 claims description 12
- 238000005325 percolation Methods 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 10
- 241000005787 Cistanche Species 0.000 claims description 9
- 241000660877 Coridius Species 0.000 claims description 9
- 241000237636 Pheretima Species 0.000 claims description 9
- 241000131808 Scolopendra Species 0.000 claims description 9
- 241000243172 Spongilla Species 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000006071 cream Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims 3
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 244000001632 Acorus gramineus Species 0.000 abstract 1
- 235000013073 Acorus gramineus Nutrition 0.000 abstract 1
- 241000202726 Bupleurum Species 0.000 abstract 1
- 241000258920 Chilopoda Species 0.000 abstract 1
- 241000212948 Cnidium Species 0.000 abstract 1
- 240000007371 Cuscuta campestris Species 0.000 abstract 1
- 241000545744 Hirudinea Species 0.000 abstract 1
- 244000131360 Morinda citrifolia Species 0.000 abstract 1
- 235000008898 Morinda citrifolia Nutrition 0.000 abstract 1
- 235000008248 Morinda citrifolia var citrifolia Nutrition 0.000 abstract 1
- 241000243169 Spongillidae Species 0.000 abstract 1
- 241001533104 Tribulus terrestris Species 0.000 abstract 1
- 235000017524 noni Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 7
- 238000011084 recovery Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 230000001568 sexual effect Effects 0.000 description 5
- 238000000605 extraction Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 210000003899 penis Anatomy 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000009986 erectile function Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- -1 sublimed preparation Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010066364 Hypersexuality Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000003023 adrenocorticotropic effect Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 235000015091 medicinal tea Nutrition 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 230000009329 sexual behaviour Effects 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a medicine composition for curing impotence, which comprises puncturevine caltrop fruit, bupleurum root, pberetima, honeycomb, leech, jiuxiang bug, freshwater sponge, common cnidium fruit, polygala root, herba cistanchis, dodder seed, fructus, medicinal indianmulberry root, centipede and grassleaf sweetflag rhizome. The medicine of the present invention is used for curing impotence. Total effective rate reaches 81.04%, and cure rate is 65.71%.
Description
The present invention is a kind of medicine for the treatment of sexual impotence, be specifically a kind of be the Chinese patent medicine that effective ingredient is prepared from the Chinese herbal medicine, belong to field of pharmaceutical preparations.
Sexual impotence is a kind of common andropathy, and sickness rate is higher, influences the stability of male's physical and mental health and family and society.According to external property clinic's statistics, impotence patient accounts for the 37%-42% of whole male sexual disorder.According to domestic fragmentary sampling survey, in adult male, there is 10% people that the sexual impotence performance is arranged approximately.The generation of this disease directly influences the stable of family, and what petitioned for a divorce in the whole nation in 1987 has 1,100,000 pairs, wherein accounts for 35% more than to what the divorce reason openly was referred to as " sexual life is inharmonious ".And along with the raising of social civilization degree and the change of cultural concept, people increase day by day to the urgency of this disease treatment.But, for the treatment of sexual impotence, how to be its well-established law traditionally to control from the kidney opinion, bias toward warming and recuperating the kidney-YANG.At present, still be difficult " sexual impotence is controlled from the liver opinion " thinking on the market and treat this sick medicine.
The objective of the invention is to overcome the prejudice of traditional treatment sexual impotence, providing a kind of is the medicine that the Therapeutic Principle invents with " controlling from the liver opinion ".
The objective of the invention is to realize according to following theory and technology scheme.
The inventor is in andrology's clinical practice for many years, the sexual impotence pathogenesis is proposed the viewpoint of " sexual impotence is controlled from the liver opinion ", think that blood fortune obstacle is the major reason that influence is erected, on the clinical basis of using decoction treatment sexual impotence, according to the medication experience of oneself, in conjunction with arrangement and record of research literature of ancient book and modern pharmacology data,, developed the new drug of treatment sexual impotence by clinical repeated screening.
Capsule of the present invention is composed as follows by weight ratio:
Fructus Tribuli 400-950 part
Radix Bupleuri 10-80 part
Pheretima 10-80 part
Nidus Vespae 10-80 part
Hirudo 10-60 part
Aspongopus 10-50 part
Spongilla 5-30 part
Fructus Cnidii 100-200 part
Radix Polygalae 40-90 part
Herba Cistanches 10-80 part
Semen Cuscutae 10-80 part
Fructus Schisandrae Chinensis 10-50 part
Radix Morindae Officinalis 10-50 part
Scolopendra 20-80 part
Rhizoma Acori Graminei 10-50 part
The preferred weight proportioning of capsule of the present invention is:
Fructus Tribuli 600-800 part
Radix Bupleuri 30-60 part
Pheretima 30-60 part
Nidus Vespae 30-60 part
Hirudo 20-40 part
Aspongopus 15-35 part
Spongilla 5-20 part
Fructus Cnidii 140-180 part
Radix Polygalae 50-80 part
Herba Cistanches 30-60 part
Semen Cuscutae 30-60 part
Fructus Schisandrae Chinensis 20-35 part
Radix Morindae Officinalis 10-30 part
Scolopendra 20-40 part
Rhizoma Acori Graminei 20-40 part
Aforementioned pharmaceutical compositions of the present invention can be prepared into any pharmaceutical dosage form, comprises tablet, pill, capsule, sublimed preparation, unguentum, oral liquid, medicated wine, medicinal tea, injection etc.Can also contain conventional pharmaceutical excipient in the said pharmaceutical preparation, for example, disintegrating agent, binding agent, thickening agent, emulsifying agent etc.
In the above-mentioned pharmaceutical preparation process of preparation,, above-mentioned pharmaceutical composition can be pulverized simply, mixed or pass through and extract, make preparation according to the needs of different dosage form.
The preparation method of medicine capsule of the present invention is as follows:
1, the process of preparing Chinese medicine of crude drug and pretreatment
More than 15 flavor medicines, concoct about the concocting method of crude drug under the Chinese medicine processing item by Pharmacopoeia of People's Republic of China (nineteen ninety version).
Respectively with Fructus Tribuli, Radix Bupleuri, Radix Polygalae, Fructus Schisandrae Chinensis, Hirudo below 80 ℃, dry 4 hours, be broken into coarse powder, standby.
2, extraction process
(1), reflux, extract: Fructus Tribuli, Radix Bupleuri, Radix Polygalae are added 4,3,3 times of amounts of 70% ethanol, and reflux 3 times each 2 hours, filters, merging filtrate, decompression recycling ethanol is concentrated into thick paste shape (d=1.19,20 ℃ of mother-in-law Mei Shi proportion instrumentations), the intermediate recovery rate is not less than 12%, and is standby.
(2), percolation: Hirudo, Fructus Cnidii, Fructus Schisandrae Chinensis are made solvent according to percolation (Pharmacopoeia of People's Republic of China nineteen ninety version appendix 17) with 60% ethanol, flooded 12 hours, with the speed of per minute 1-3 milliliter percolation slowly, approaching colourless to the liquid of filtering, stop percolation, collect 8 times of amounts of the suitable crude drug of percolate, filter liquid and be concentrated into thick paste shape (d=1.19 of reclaim under reduced pressure, 20 ℃ of mother-in-law Mei Shi proportion instrumentations), the intermediate recovery rate is not less than 10%.
(3), boil and carry: Pheretima, Nidus Vespae, Herba Cistanches, Radix Morindae Officinalis, Semen Cuscutae (cloth bag), add 8,6, the 5 times amounts of water, decoct respectively three times, decocted 2 hours for the first time when crude drug, decocted 1.5 hours for the second time, decocted for the third time 1 hour, and filtered merging filtrate respectively, be concentrated into thick paste shape (d=1.19,20 ℃ of mother-in-law Mei Shi proportion instrumentations), the intermediate recovery rate is not less than 16%, and is standby.
(4), drying: merge 1,2,3 thick pastes, in below 80 ℃, vacuum drying gets the loose dried cream of dark brown brown, and yield is not less than 8%.
3, pulverize: with Aspongopus, Spongilla, Rhizoma Acori Graminei, Scolopendra, with 75% ethanol moistening 1 hour, airing, below 70 ℃, drying was pulverized 60 mesh sieves, mixing, after 60 mesh sieves, flour extraction is not less than 85%,
4, mixing, granulation, encapsulated:
The dried cream that step 2 (4) is made mixes with the medicated powder that step 3 makes, and pulverizes, and crosses 100 mesh sieves, and mixing after 100 mesh sieves, is made soft material in right amount with 85% ethanol, crosses 14 mesh sieves, granulates, and is dry in about 60 ℃, after 14 mesh sieves, and granulate, encapsulated.
Prove through pharmacodynamic experiment: medicine of the present invention can improve the irritability of castration rat penis to outside stimulus, can strengthen penile erectile function.Mating test, male white rat gavage drug suspension of the present invention can strengthen erection and sexual intercourse function.Medicine of the present invention can promote immaturity white mice prostate, Seminal vesicle, testis and the weightening finish of the attached property of levator ani organ pipe growth promoter, can impel ripe rat serum testosterone content to increase again, and the effect of androgen sample is arranged.Medicine of the present invention has the effect of adrenotrophic hormone sample, can increase hepatic glycogen, makes immature white mouse atrophy of thymus gland, makes vitamin C reduction in the rat adrenal gland; Medicine of the present invention has strong effect, and white mice gavages the suspension of medicine of the present invention, and the energy health invigorating has resisting fatigue and resisting oxygen lack.Hemorheology Study shows: rat gavages the suspension of medicine of the present invention, certain blood viscosity lowering is arranged, reduce platelet aggregation and reduce the trend that Fibrinogen generates, the blood circulation that has some improvement, reproductive system blood supply insufficiency and function of promoting blood circulation to disperse blood clots.
Sexual behaviour laboratory observation result confirms the erection function of medicine of the present invention to the male monkey of erection disturbance, and penis inserts and the ejaculation function improves significantly during sexual intercourse, and pleasant sensation and orgasm can improve male monkey libido and sexual intercourse the time.
Rhesus Macacus erection test shows: can obviously recover with Drug therapy of the present invention, further confirm that from clinical objective indicator medicine of the present invention has significant effect to the treatment penile erectile function.
Drug therapy sexual impotence 210 examples of the present invention, total effective rate reaches 81.04%, and cure rate is 65.71%.Obtained satisfied clinical efficacy.
We are in using medicine process of the present invention, realizing this medicine can hypersexuality, the property eliminated detest sense, to there not being the spontaneous patient who erects, great majority can recover the ability of its spontaneous erection after taking medicine of the present invention, penis is lifted and the patient of not hard or anorthosis can promote erection specifically during for sexual intercourse.For the simultaneous phenomenon of sexual impotence, medicine of the present invention all has the improvement effect, and we know from experience, and this medicine is contrary disorderly to depression of liver-QI and mechanism of qi, qi depression to blood stasis symptom curative effect is higher, for other symptom obvious therapeutic efficiency is also arranged.Lift and not hard with premature ejaculation person, curative effect is also felt quite pleased.
Embodiment prepares the capsule of medicine of the present invention
Fructus Tribuli 725
Radix Bupleuri 45 grams
Pheretima 45 grams
Nidus Vespae 46 grams
Hirudo 30
Aspongopus 25 grams
Spongilla 10 grams
Fructus Cnidii 160 grams
Radix Polygalae 75 grams
Herba Cistanches 50 grams
Semen Cuscutae 50 grams
Fructus Schisandrae Chinensis 30 grams
Radix Morindae Officinalis 20 grams
Scolopendra 30 grams
Rhizoma Acori Graminei 30 grams
Method for making:
1, the process of preparing Chinese medicine of crude drug and pretreatment
More than 15 flavor medicines, concoct about the concocting method of crude drug under the Chinese medicine processing item by Pharmacopoeia of People's Republic of China (nineteen ninety version).
Respectively with Fructus Tribuli, Radix Bupleuri, Radix Polygalae, Fructus Schisandrae Chinensis, Hirudo below 80 ℃, dry 4 hours, be broken into coarse powder, standby.
2, extraction process
(1), reflux, extract: Fructus Tribuli, Radix Bupleuri, Radix Polygalae are added 4,3,3 times of amounts of 70% ethanol, and reflux 3 times each 2 hours, filters, merging filtrate, decompression recycling ethanol is concentrated into thick paste shape (d=1.19,20 ℃ of mother-in-law Mei Shi proportion instrumentations), the intermediate recovery rate is not less than 12%, and is standby.
(2), percolation: Hirudo, Fructus Cnidii, Fructus Schisandrae Chinensis are made solvent according to percolation (Pharmacopoeia of People's Republic of China nineteen ninety version appendix 17) with 60% ethanol, flooded 12 hours, with the speed of per minute 1-3 milliliter percolation slowly, approaching colourless to the liquid of filtering, stop percolation, collect 8 times of amounts of the suitable crude drug of percolate, filter liquid and be concentrated into thick paste shape (d=1.19 of reclaim under reduced pressure, 20 ℃ of mother-in-law Mei Shi proportion instrumentations), the intermediate recovery rate is not less than 10%.
(3), boil and carry: Pheretima, Nidus Vespae, Herba Cistanches, Radix Morindae Officinalis, Semen Cuscutae (cloth bag), add 8,6, the 5 times amounts of water, decoct respectively three times, decocted 2 hours for the first time when crude drug, decocted 1.5 hours for the second time, decocted for the third time 1 hour, and filtered merging filtrate respectively, be concentrated into thick paste shape (d=1.19,20 ℃ of mother-in-law Mei Shi proportion instrumentations), the intermediate recovery rate is not less than 16%, and is standby.
(4), drying: merge 1,2,3 thick pastes, in below 80 ℃, vacuum drying, the loose dried cream of dark brown brown, yield is not less than 8%,
3, pulverize: with Aspongopus, Spongilla, Rhizoma Acori Graminei, Scolopendra, with 75% ethanol moistening 1 hour, airing, below 70 ℃, drying was pulverized 60 mesh sieves, mixing, after 60 mesh sieves, flour extraction is not less than 85%.
4, mixing, granulation, encapsulated:
The dried cream that step 2 (4) is made mixes with the medicated powder that step 3 makes, and pulverizes, and crosses 100 mesh sieves, and mixing is after 100 mesh sieves, make soft material in right amount with 85% ethanol, cross 14 mesh sieves, granulate, dry in about 60 ℃, after 14 mesh sieves, granulate, encapsulated, make 1000 capsules.
Claims (3)
1, a kind of capsule for the treatment of sexual impotence is characterized in that it is made by the following weight proportion raw material:
Fructus Tribuli 400-950 part
Radix Bupleuri 10-80 part
Pheretima 10-80 part
Nidus Vespae 10-80 part
Hirudo 10-60 part
Aspongopus 10-50 part
Spongilla 5-30 part
Fructus Cnidii 100-200 part
Radix Polygalae 40-90 part
Herba Cistanches 10-80 part
Semen Cuscutae 10-80 part
Fructus Schisandrae Chinensis 10-50 part
Radix Morindae Officinalis 10-50 part
Scolopendra 20-80 part
Rhizoma Acori Graminei 10-50 part
The method for preparing described capsule:
1) pretreatment of crude drug
Respectively with Fructus Tribuli, Radix Bupleuri, Radix Polygalae, Fructus Schisandrae Chinensis, Hirudo below 80 ℃, dry 4 hours, be broken into coarse powder, standby;
2) extract
(a) reflux, extract: Fructus Tribuli, Radix Bupleuri, Radix Polygalae are added 4,3,3 times of amounts of 70% ethanol, reflux 3 times, each 2 hours, filter, merging filtrate, decompression recycling ethanol is concentrated into the thick paste shape, and is standby;
(b) percolation: Hirudo, Fructus Cnidii, Fructus Schisandrae Chinensis are made solvent with 60% ethanol, flooded 12 hours, with the speed of per minute 1-3 milliliter percolation slowly, approaching colourless to the liquid of filtering, stop percolation, collect 8 times of amounts of the suitable crude drug of percolate, filter liquid and be concentrated into the thick paste shape of reclaim under reduced pressure;
(c) boil and carry: Pheretima, Nidus Vespae, Herba Cistanches, Radix Morindae Officinalis, Semen Cuscutae are added 8,6, the 5 times amounts of water when crude drug, decoct respectively three times, decocted 2 hours for the first time, decocted 1.5 hours for the second time, decocted for the third time 1 hour, filter respectively, merging filtrate, it is standby to be concentrated into the thick paste shape;
(d) drying: merge a, b, the thick paste of c, in below 80 ℃, vacuum drying gets the loose dried cream d of dark brown brown;
3) pulverize: with Aspongopus, Spongilla, Rhizoma Acori Graminei, Scolopendra, with 75% ethanol moistening 1 hour, airing, below 70 ℃, drying was pulverized 60 mesh sieves, and mixing is after 60 mesh sieves, must medicated powder standby;
4) mixing, granulation, encapsulated:
The dried cream d that makes is mixed with the medicated powder that step 3 makes, pulverize, cross 100 mesh sieves, mixing after 100 mesh sieves, is made soft material in right amount with 85% ethanol, crosses 14 mesh sieves, granulates, and is dry in about 60 ℃, after 14 mesh sieves, and granulate, encapsulated.
2,, it is characterized in that it is made by the following weight proportion raw material according to the capsule of claim 1:
Fructus Tribuli 600-800 part
Radix Bupleuri 30-60 part
Pheretima 30-60 part
Nidus Vespae 30-60 part
Hirudo 20-40 part
Aspongopus 15-35 part
Spongilla 5-20 part
Fructus Cnidii 140-180 part
Radix Polygalae 50-80 part
Herba Cistanches 30-60 part
Semen Cuscutae 30-60 part
Fructus Schisandrae Chinensis 20-35 part
Radix Morindae Officinalis 10-30 part
Scolopendra 20-40 part
Rhizoma Acori Graminei 20-40 part
3,, it is characterized in that it is made by the following weight proportion raw material according to the capsule of claim 2:
725 parts of Fructus Tribulis
45 parts of Radix Bupleuri
45 parts of Pheretimas
46 parts in Nidus Vespae
30 parts of Hirudos
25 parts of Aspongopuss
10 parts of Spongilla
160 parts of Fructus Cnidiis
75 parts of Radix Polygalaes
50 parts of Herba Cistanches
50 parts of Semen Cuscutae
30 parts of Fructus Schisandrae Chinensis
20 parts of Radix Morindae Officinaliss
30 parts of Scolopendras
30 parts of Rhizoma Acori Graminei
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96109801A CN1058170C (en) | 1996-09-16 | 1996-09-16 | Drug for treating sexual impotence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96109801A CN1058170C (en) | 1996-09-16 | 1996-09-16 | Drug for treating sexual impotence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1176799A CN1176799A (en) | 1998-03-25 |
| CN1058170C true CN1058170C (en) | 2000-11-08 |
Family
ID=5120620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96109801A Expired - Lifetime CN1058170C (en) | 1996-09-16 | 1996-09-16 | Drug for treating sexual impotence |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1058170C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397416A (en) * | 2010-09-13 | 2012-04-04 | 贵州益佰制药股份有限公司 | Medicinal composition for treating erectile dysfunction (ED), its preparation method and preparations |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461872B (en) * | 2009-01-08 | 2012-06-13 | 郭凯 | Medicament composition for treating erectile dysfunction and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100645A (en) * | 1993-09-25 | 1995-03-29 | 王伊斌 | Health-care bolus for invigorating kidney and improving sexual function |
-
1996
- 1996-09-16 CN CN96109801A patent/CN1058170C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100645A (en) * | 1993-09-25 | 1995-03-29 | 王伊斌 | Health-care bolus for invigorating kidney and improving sexual function |
Non-Patent Citations (1)
| Title |
|---|
| 中草药1983,14(12) 1983.1.1 陈馨，黄芪建中汤注射剂作用 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397416A (en) * | 2010-09-13 | 2012-04-04 | 贵州益佰制药股份有限公司 | Medicinal composition for treating erectile dysfunction (ED), its preparation method and preparations |
| CN102397416B (en) * | 2010-09-13 | 2014-09-03 | 贵州益佰制药股份有限公司 | Medicinal composition for treating erectile dysfunction (ED) and its preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1176799A (en) | 1998-03-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1785284A (en) | Medicinal composition containing flowery knotwood root | |
| CN1422622A (en) | Herba-Epimedii extract for treating prostatic hyerplasia and use in preparing medicine | |
| CN1058170C (en) | Drug for treating sexual impotence | |
| CN1298362C (en) | Compound Chinese medicine prepn for treating pulvic infection and its prepn process | |
| CN1232279C (en) | Antilipemic Chinese medicine | |
| CN1139565A (en) | Nourishing medicine for preventing and curing toxic and side effect after tumor radiotherapy and chemotherapy and preparation method | |
| CN1087275A (en) | Treatment ischemic brain, cardiovascular preparation Shumaining | |
| CN105477465A (en) | Chinese herb preparation with liver protection function and preparing technology of Chinese herb preparation | |
| CN1111045C (en) | Chewing medicine for treating facial paralysis and its preparing process | |
| CN1839931B (en) | Medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof | |
| CN1319578C (en) | Prescription of Chinese medicine compound preparation, its preparation method and use | |
| CN1263490C (en) | Yang reinforcing medicine and its preparation method | |
| CN1640436A (en) | Chinese medicine composition for treating menstrual period syndrome | |
| CN1201811C (en) | Chinese medicine composition for treating myopia and preparing method thereof | |
| CN1216626C (en) | Shenhong capsule with actions of removing blood stasis and obstruction | |
| CN1254260C (en) | Medicine composition containing epimedium extract | |
| CN1079396A (en) | Intelligence-enhancing pharmaceutical preparation | |
| CN1281252C (en) | Medicinal composition for treating urinary lithiasis and its preparing method | |
| CN1310669C (en) | Medicine composition for treating chronic hepatitis and its prepn | |
| CN1126558C (en) | Medicine for treating kidney damage caused by immunological disease lupus erythematosus | |
| CN101194963B (en) | Process for preparing medicine for treating headache | |
| CN1733107A (en) | Medicine for treating coronary disease and apoplexy sequelae and process for preparing the same | |
| CN1244340C (en) | Chinese medicine for treating coronary heart disease and angina pectoris and its preparing process | |
| CN1634241A (en) | Compound formulation of notoginseng for treating cardiovascular and cerebrovascular diseases and its preparing process | |
| CN1244339C (en) | Chinese medicine for treating and preventing fatty liver and its preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: YIBAI PHARMACEUTICAL CO., LTD., GUIZHOU Free format text: FORMER OWNER: WANG QI Effective date: 20140310 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100091 HAIDIAN, BEIJING TO: 550008 GUIYANG, GUIZHOU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20140310 Address after: 550008 Baiyun Avenue, Guizhou, Guiyang 220-1 Patentee after: Yibai Pharmaceutical Co., Ltd., Guizhou Address before: 100091 Xiyuan Hospital of Beijing City Patentee before: Wang Qi |
|
| CX01 | Expiry of patent term |
Granted publication date: 20001108 |
|
| EXPY | Termination of patent right or utility model |