CN105816565A - Composition for treating enteritis of black carps - Google Patents

Composition for treating enteritis of black carps Download PDF

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Publication number
CN105816565A
CN105816565A CN201610362469.9A CN201610362469A CN105816565A CN 105816565 A CN105816565 A CN 105816565A CN 201610362469 A CN201610362469 A CN 201610362469A CN 105816565 A CN105816565 A CN 105816565A
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group
parts
herba
experiment
enteritis
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汪先足
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Farming Of Fish And Shellfish (AREA)

Abstract

The invention belongs to the field of aquaculture and particularly discloses a composition for treating enteritis of black carps .The composition comprises, by mass, 8-12 parts of herbs of denseflower blumea, 8-12 parts of scoparia dulcis L., 4-6 parts of patrinia scabiosifolia fisch .ex Trevir .and 3-5 parts of herbs of common sowthistle .The cure rate of the composition to enteritis of black carps can reach 85% or above .

Description

A kind of compositions treating Mylopharyngodon piceus enteritis disease
Technical field
The present invention relates to aquaculture field, be specifically related to a kind of compositions treating Mylopharyngodon piceus enteritis disease.
Background technology
Mylopharyngodon piceus is one of four large Chinese carps, is a kind of high protein, low-fat food, and its protein content is 20.1%, and fat content is 4.2%.In aminoacid forms, rich in glutamic acid, aspartic acid etc. in delicate flavour composition, therefore delicious flavour of tasting.Mylopharyngodon piceus Pork is thick, and greasiness is delicious, and thorn is big and lacks, and containing the mineral such as saccharide, multivitamin and zinc, calcium, phosphorus, ferrum, magnesium, is Top grade in fresh-water fishes.Mylopharyngodon piceus is rich in lysine, and general lack of lysine in the daily staple food of people, the most often eats Mylopharyngodon piceus and can send out Wave protein complementary action, promote the nutritive value of food.
Enteritis disease is one of disease the most serious in China's cultured fishes, and its cause of disease is addicted to aqueous vapor pseudomonas bacillus, for Gram-negative Bacterium.Suffering from the Mylopharyngodon piceus of enteritis disease to peel off solely trip, slow trip, fish body turns black, few food or do not eat；Abdominal part expands, and presents erythema, anus Door is red and swollen prominent；Mention disease fish head portion, have faint yellow mucus to flow out from anus；Cutting intestinal tube open, intestinal wall hyperemia inflammation, in enteric cavity Do not have food or only back segment at intestinal have a small amount of feces, the how faint yellow mucus of enteral, intestinal wall poor flexibility, scale is easy to fall off, causes Fish mortality, this disease annual 5～June, the Mylopharyngodon piceus endangering for 1～2 ages more.
The method of traditional treatment enteritis disease is: bleaching powder full pond float, makes water become the concentration of lmg/L；Take Herba Euphorbiae Humifusae orally simultaneously, Fish is fed by Radix Glycyrrhizae 0.5～lkg/100kg, every day 1 time, continuous 5 days.This method to the cure rate of Mylopharyngodon piceus enteritis disease 75% Left and right.
Summary of the invention
It is an object of the invention to provide a kind of compositions treating Mylopharyngodon piceus enteritis disease, the said composition cure rate to Mylopharyngodon piceus enteritis disease More than 85% can be reached.
For reaching above-mentioned purpose, the base case of the present invention is: a kind of compositions treating Mylopharyngodon piceus enteritis disease, according to mass fraction Meter, including Herba Blumeae Densiflorae 8-12 part, Sweet Broomwort Herb 8-12 part, Herba Patriniae 4-6 part, Herba Sonchi Oleracei 3-5 part.
Herba Blumeae Densiflorae has clearing away heat and cooling blood, effect of preventing the attack (or recurrence) of malaria；Cure mainly malaria, enteritis, cat fever.Sweet Broomwort Herb has clearing away heat-damp and promoting diuresis, Effect that dispelling wind is antipruritic, for enteritis, bacillary dysentery, cold, fever, dysuria；Miliaria, skin eczema are controlled in external. Herba Patriniae has heat-clearing and toxic substances removing, effect of evacuation of pus removing blood stasis with potent drugs；Control acute appendicitis, dysentery, puerperal the stagnant stomachache of the stasis of blood, carbuncle scabies.Herba Sonchi Oleracei has Heat-clearing and toxic substances removing, removing blood stasis with potent drugs invigorates blood circulation, effect of evacuation of pus；For appendicitis, peritoneal abscess, enteritis, dysentery, spit blood, epistaxis；Outward With controlling traumatic injury, furuncle swells and ache, impetigo, eczema scrotum.
The program have the beneficial effect that one be treatment Mylopharyngodon piceus enteritis disease remarkably productive, cure rate reaches more than 85%；Two is choosing Treat enteritis disease with Chinese herbal medicine, while regulation fish internal milieu balance, increase fish body immunity, improve Mylopharyngodon piceus and resist it The ability of his disease.
Prioritization scheme one: the optimization as to base case: according to mass fraction meter, also comprises Caulis et Folium fici Tikouae 7-9 part, Herba veronicastri villosuli 1-2 part.Caulis et Folium fici Tikouae has heat clearing away, dampness removing, invigorates blood circulation, effect of removing toxic substances；Control dysentery, edema, jaundice, rheumatalgia, hemorrhoid Skin ulcer is hemorrhage, infantile dyspepsia, innominate toxic swelling.Herba veronicastri villosuli has inducing diuresis to remove edema, effect of dissipating blood stasis removing toxic substances；For ascites, water Swollen, dysuria, traumatic injury；Parotitis, furuncle, burn and scald, venom are controlled in external.The beneficial effect of this programme removes Outside treatment Mylopharyngodon piceus enteritis disease, also there is dissipating blood stasis removing toxic substances, effect of heat clearing and blood circulation promoting, the malaise symptoms of ill Mylopharyngodon piceus can be alleviated, Improve recovery from illness speed.
Prioritization scheme two: the optimization as to prioritization scheme one: also include cefotaxime sodium 0.01 part.Cefotaxime sodium is wide spectrum Antibiotic, the effect to gram-negative bacteria is strong, to Observation on Specificity of Blood-sucking hemophilus influenza, escherichia coli, the white aerobacteria of salmonella Cray Belong to and proteus mirabilis, neisseria, staphylococcus, streptococcus pneumoniae, streptococcus etc. have the strongest killing action.Cause green grass or young crops The cause of disease of fish enteritis is addicted to aqueous vapor pseudomonas bacillus, belongs to gram negative bacteria, and Cefotaxime sodium is sensitive, adds cefotaxime After sodium, can be with the effect of enhancing composition treatment Mylopharyngodon piceus enteritis disease.
Prioritization scheme three: the optimization as to prioritization scheme two: according to mass fraction meter, also includes fosfomycin 0.01 part.Phosphorus is mould The mechanism of action of element is to combine with a kind of bacteria cell wall synzyme, and hindering antibacterial to utilize has the first of related substance synthetic cell wall Step reaction, thus suppress the synthesis of bacteria cell wall, play bactericidal action.Fosfomycin is mainly used in the gram-negative bacteria of sensitivity and causes Urinary tract, skin and the site infection such as soft tissue, intestinal.Add fosfomycin and can further enhance compositions treatment Mylopharyngodon piceus enteritis Sick effect.
Detailed description of the invention
Below by detailed description of the invention, the present invention is further detailed explanation:
Setup Experiments blank group, matched group, experiment A group, experiment B group, experiment C group, experiment D group, experiment E group, reality Testing F group, each group with an independent culturing pool.The sick fish that 240 tails suffer from moderate enteritis disease is the most all assigned in eight groups, Often organize 30 tails.Outside divided by lower process difference, remaining condition is the most identical:
Blank group: not treated with medicaments.
Matched group: bleaching powder full pond float, makes water become the concentration of lmg/L；Take Herba Euphorbiae Humifusae orally simultaneously, by Radix Glycyrrhizae 0.5～ The consumption of lkg/100kg, admixes and feeds fish in feedstuff, every day 1 time, continuous 5 days.
Experiment A group: use compositions, according to mass fraction meter, including Herba Blumeae Densiflorae 8 parts, Sweet Broomwort Herb 12 parts, Herba Patriniae 4 parts, Herba Sonchi Oleracei 5 parts.
Experiment B group: use compositions, according to mass fraction meter, including Herba Blumeae Densiflorae 12 parts, Sweet Broomwort Herb 8 parts, Herba Patriniae 6 parts, Herba Sonchi Oleracei 3 parts.
Experiment C group: use compositions, according to mass fraction meter, including Herba Blumeae Densiflorae 11 parts, Sweet Broomwort Herb 9 parts, Herba Patriniae 5 parts, Herba Sonchi Oleracei 4 parts.Caulis et Folium fici Tikouae 7 parts, Herba veronicastri villosuli 2 parts.
Experiment D group: use compositions, according to mass fraction meter, including Herba Blumeae Densiflorae 9 parts, Sweet Broomwort Herb 11 parts, Herba Patriniae 4.4 parts, Herba Sonchi Oleracei 3.5 parts, Caulis et Folium fici Tikouae 9 parts, Herba veronicastri villosuli 1 part.
Experiment E group: use compositions, according to mass fraction meter, including Herba Blumeae Densiflorae 10 parts, Sweet Broomwort Herb 8.5 parts, Herba Patriniae 5.6 Part, Herba Sonchi Oleracei 4.7 parts, Caulis et Folium fici Tikouae 8 parts, Herba veronicastri villosuli 1.3 parts, cefotaxime sodium 0.01 part.
Experiment F group: use compositions, according to mass fraction meter, including Herba Blumeae Densiflorae 11.3 parts, Sweet Broomwort Herb 10 parts, Herba Patriniae 5.2 Part, Herba Sonchi Oleracei 3.3 parts, Caulis et Folium fici Tikouae 7.7 parts, Herba veronicastri villosuli 1.7 parts, cefotaxime sodium 0.01 part, fosfomycin 0.01 part.
Wherein, experiment A group to experiment D group, decoct compositions according to the method for decocting herb, obtain medicinal liquid and medicinal residues；By medicinal liquid According to 0.3L/m3Consumption splash full pond, every day 1 time, continuous 5 days；Powder beaten by medicinal residues, by medicinal residues powder with feedstuff according to 1:10 Ratio throw something and feed Mylopharyngodon piceus, every day 1 time, continuous 5 days.
Experiment E group and the difference testing A group are, splash behind full pond with medicinal liquid, after wait 0.5h, use cefotaxime sodium Aqueous solution splash full pond.The processing method of medicinal residues powder is identical.
Experiment F group and the difference testing E group are, splash behind full pond with the aqueous solution of cefotaxime sodium, wait 1h, so Splash full pond with the aqueous solution of fosfomycin afterwards.The processing method of medicinal residues powder is identical.
After 5 days, experimental result is as follows:
Blank group Matched group Experiment A group Experiment B group Experiment C group Experiment D group Experiment E group Experiment F group
Cure (tail) 0 22 27 26 29 28 29 30
Take a turn for the better (tail) 0 8 2 4 0 2 1 0
Dead (tail) 27 2 1 0 1 0 0 0
Result is added up:
Blank group: dead 27 tail, other 3 shape of tail states are very poor, tend to disease and die；Mortality rate 90.0%.
Matched group: cure rate 73.3%, improvement rate 26.7%, mortality rate 6.7%.
Experiment A group: cure rate 90.0%, improvement rate 6.7%, mortality rate 3.3%.
Experiment B group: cure rate 86.7%, improvement rate 13.3%, mortality rate 0.
Experiment C group: cure rate 96.7%, improvement rate 0%, mortality rate 3.3%.
Experiment D group: cure rate 93.3%, improvement rate 6.7%, mortality rate 0.
Experiment E group: cure rate 96.7%, improvement rate 3.3%, mortality rate 0.
Experiment F group: cure rate 100%, improvement rate 0%, mortality rate 0.
Interpretation of result: experiment A group and B group are to have employed the base case of the present invention, experiment C group is to use to experiment F group The preferred version of base case, the cure rate of these six experimental grouies is all significantly better than the matched group of employing conventional solution, dead Rate is significantly lower than matched group.As can be seen here, the present invention compared to existing technology, has prominent substantive distinguishing features and significantly progress.
Above-described is only embodiments of the invention, and in scheme, the known general knowledge such as using method and characteristic is too much retouched at this State.It should be pointed out that, for a person skilled in the art, under the premise of not departing from the present invention, it is also possible to make some changing Entering, these also should be considered as protection scope of the present invention, and these are all without affecting effect and the practical applicability that the present invention implements. The protection domain that this application claims should be as the criterion with the content of its claim, and the detailed description of the invention in description etc. is recorded permissible For explaining the content of claim.

Claims (4)

1. the compositions treating Mylopharyngodon piceus enteritis disease, it is characterised in that: according to mass fraction meter, including Herba Blumeae Densiflorae 8-12 part, ice Sugar grass 8-12 part, Herba Patriniae 4-6 part, Herba Sonchi Oleracei 3-5 part.
A kind of compositions treating Mylopharyngodon piceus enteritis disease the most according to claim 1, it is characterised in that: according to mass fraction meter, Also comprise Caulis et Folium fici Tikouae 7-9 part, Herba veronicastri villosuli 1-2 part.
A kind of compositions treating Mylopharyngodon piceus enteritis disease the most according to claim 2, it is characterised in that: according to mass fraction meter, Also include cefotaxime sodium 0.01 part.
A kind of compositions treating Mylopharyngodon piceus enteritis disease the most according to claim 3, it is characterised in that: according to mass fraction meter, Also include fosfomycin 0.01 part.
CN201610362469.9A 2016-05-27 2016-05-27 Composition for treating enteritis of black carps Pending CN105816565A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106138398A (en) * 2016-08-22 2016-11-23 重庆市万州区石人滩农业发展有限公司 A kind of composition treating silver carp enteritis disease
CN106689808A (en) * 2016-12-09 2017-05-24 陈周英 Feed for enhancing immunity of black carps
CN106822240A (en) * 2016-12-02 2017-06-13 重庆市长寿区祥金贵淡水鱼养殖场 A kind of composition for treating variegated carp enteritis disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104027507A (en) * 2014-05-15 2014-09-10 当涂县科辉商贸有限公司 Traditional Chinese medicine decoction for treating ulcerative colitis
CN104758802A (en) * 2015-03-06 2015-07-08 钟云仙 Chinese medicinal composition for treatment of Mylopharyngodon piceus bacterial enteritis
CN104940370A (en) * 2015-07-22 2015-09-30 资源县民生水产养殖有限责任公司 Traditional Chinese medicine for preventing and treating enteritis of rainbow trouts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104027507A (en) * 2014-05-15 2014-09-10 当涂县科辉商贸有限公司 Traditional Chinese medicine decoction for treating ulcerative colitis
CN104758802A (en) * 2015-03-06 2015-07-08 钟云仙 Chinese medicinal composition for treatment of Mylopharyngodon piceus bacterial enteritis
CN104940370A (en) * 2015-07-22 2015-09-30 资源县民生水产养殖有限责任公司 Traditional Chinese medicine for preventing and treating enteritis of rainbow trouts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
汪德刚，戴永海 主编: "六、鱼肠炎病", 《中兽医防治技术》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106138398A (en) * 2016-08-22 2016-11-23 重庆市万州区石人滩农业发展有限公司 A kind of composition treating silver carp enteritis disease
CN106822240A (en) * 2016-12-02 2017-06-13 重庆市长寿区祥金贵淡水鱼养殖场 A kind of composition for treating variegated carp enteritis disease
CN106689808A (en) * 2016-12-09 2017-05-24 陈周英 Feed for enhancing immunity of black carps

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Application publication date: 20160803