CN105807039B - Thrombus elastometer - Google Patents
Thrombus elastometer Download PDFInfo
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- CN105807039B CN105807039B CN201610278393.1A CN201610278393A CN105807039B CN 105807039 B CN105807039 B CN 105807039B CN 201610278393 A CN201610278393 A CN 201610278393A CN 105807039 B CN105807039 B CN 105807039B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
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Abstract
The invention discloses a kind of thrombus elastometers, including：Bracket, rotary shaft and position correction apparatus；The bracket is connected with one end of the rotary shaft, and the bracket is placed in the other end of the rotary shaft in external tested blood for being supported to the rotary shaft；The rotary shaft rotates under the driving effect of the tested blood；The position correction apparatus is connected with the rotary shaft, for generating the active force for rotating equilbrium position direction described in the axial rotary when the rotary shaft rotates and deviates equilbrium position.This programme can be realized the automatic calibration of rotary shaft.
Description
Technical field
The present invention relates to detection technique fields, more particularly to a kind of thrombus elastometer.
Background technique
Thrombus elastometer is a kind of laboratory apparatus for vitro detection blood blood clotting, from platelet aggregation, blood coagulation, fibrinolytic
Blood clotting process is monitored etc. entire dynamic process, to obtain the rate of blood clotting and fibrinolytic and the intensity of condensation.
The intensity of the rate and condensation of blood clotting and fibrinolytic can be used as the foundation of the clinical diagnosis of cardio-cerebrovascular diseases.
Currently, carrying out school to the rotary shaft on thrombus elastometer first when detecting by thrombus elastometer to blood
Standard makes rotary shaft be in home position, is tested blood rotation and drives rotary shaft rotation, obtains blood according to the rotation situation of rotary shaft
Liquid condensation and the rate of fibrinolytic and the intensity of condensation.
It is directed to the thrombus elastometer of the prior art, after the completion of each detection, the rotary shaft of thrombus elastometer deviates former
Beginning position calibrates rotary shaft firstly the need of by way of manually adjusting in detection next time, due to manually adjusting rotation
Shaft needs to expend longer time, causes the efficiency of detection blood blood clotting lower.
Summary of the invention
The embodiment of the invention provides a kind of thrombus elastometers, can be realized the automatic calibration of rotary shaft.
Thrombus elastometer provided in an embodiment of the present invention, including：Bracket, rotary shaft and position correction apparatus；
The bracket is connected with one end of the rotary shaft, and the bracket makes institute for being supported to the rotary shaft
The other end for stating rotary shaft is placed in external tested blood；
The rotary shaft rotates under the driving effect of the tested blood；
The position correction apparatus is connected with the rotary shaft, deviates equilbrium position for rotating in the rotary shaft
When, generate the active force for rotating equilbrium position direction described in the axial rotary.
Preferably,
The position correction apparatus includes：At least one balance spring spring；
The inner ring of each balance spring spring is fixedly connected with the outer circumference surface of the rotary shaft；
The outer ring of each balance spring spring is fixedly connected with the bracket.
Preferably,
When the position correction apparatus includes at least two balance spring spring,
In at least two balance springs spring, the hand of spiral of at least one balance spring spring from inner ring to outer ring and other trips
The hand of spiral of the silk spring from inner ring to outer ring is opposite.
Preferably,
The position correction apparatus further comprises：At least one zeroing module, wherein each zeroing module corresponding one
A balance spring spring；
Each zeroing module one end be fixedly connected with the bracket, the other end in the form of adjustable with corresponding trip
The different location of silk spring outer ring is fixedly connected, the equilbrium position to be adjusted.
Preferably,
The bracket includes：Fixed support portion, moveable support portion, first connecting portion and second connecting portion；
The first connecting portion is fixedly connected with the fixed support portion, the second connecting portion and the moveable support portion
It is fixedly connected；
The first connecting portion is connected in the form of point contact with the second connecting portion, wherein the contact of the point contact
Area is less than preset area；
It is described can rotation connection be fixedly connected with one end of the rotary shaft.
Preferably,
The first connecting portion includes：Jewel bearing, the second connecting portion include：Addendum cone；
Or,
The first connecting portion includes：Addendum cone, the second connecting portion include：Jewel bearing；
Wherein, the jewel bearing is round pie structure, is provided with conical socket in a plane of round pie structure,
The addendum cone is cone structure, and the tip of the addendum cone is located in the conical socket on the jewel bearing, the addendum cone and institute
Jewel bearing is stated to be connected in the form of the point contact that contact area is less than the preset area.
Preferably,
The bracket further comprises：At least a pair of magnet；
It is directed to every a pair of magnet, this is fixed on the fixed support portion the first magnet in magnet can described in
Dynamic support portion side, this is fixed in the moveable support portion close to the fixed support portion one the second magnet in magnet
Side；
First magnet and the second magnet parallel stacking, and two faces being close are like pole.
Preferably,
The thrombus elastometer further comprises：Measuring device；
The measuring device is measured for the rotational angle to the rotary shaft, and is turned according to the rotary shaft
Dynamic angle forms the thrombelastogram for corresponding to the tested blood.
Preferably,
The measuring device includes：Optical transmitter module, optical receiver module, reflecting piece and processing module；
The reflecting piece is fixedly connected with the rotary shaft, and the rotary shaft drives the reflecting piece rotation；
The optical transmitter module, for emitting light to the reflecting piece with fixed direction；
The reflecting piece for receiving the light of the optical transmitter module transmitting, and reflects the light received；
The optical receiver module, for receiving the light of the reflecting piece reflection with fixed direction, and according to the intensity of light
The light received is converted into corresponding electric signal, the electric signal is exported to the processing module；
The processing module, the electric signal for being converted into the optical receiver module are handled, and determine the rotation
The rotational angle of axis, and the thrombelastogram for corresponding to the tested blood is formed according to the rotational angle of the rotary shaft.
Preferably,
The optical transmitter module includes：Light emitting diode and light-guiding pillar, wherein the light emitting diode passes through the leaded light
Column emits light to the reflecting piece.
Preferably,
The optical receiver module includes：Photocell and light-guiding pillar, wherein the photocell receives institute by the light-guiding pillar
State the light of reflecting piece transmitting.
The embodiment of the invention provides a kind of thrombus elastometer, rotary shaft can rotate under the support of bracket, position school
Equipment is connected with rotary shaft, when rotating deviation equilbrium position under driving effect of the rotary shaft in tested blood, promotes
Position correction apparatus generates the active force for rotating axial rotary equilbrium position direction.In this way, when tested blood is to rotary shaft
After driving effect removal, if the location of rotary shaft is not equilbrium position, active force of the rotary shaft in position correction apparatus
Under automatically revert to equilbrium position, without being calibrated by way of manually adjusting to rotary shaft, save and rotary shaft carried out
The time of calibration improves the efficiency detected to blood blood clotting.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is the present invention
Some embodiments for those of ordinary skill in the art without creative efforts, can also basis
These attached drawings obtain other attached drawings.
Fig. 1 is a kind of schematic diagram of thrombus elastometer provided by one embodiment of the present invention；
Fig. 2 is a kind of schematic diagram for thrombus elastometer that another embodiment of the present invention provides；
Fig. 3 is a kind of schematic diagram for thrombus elastometer that another embodiment of the invention provides；
Fig. 4 is a kind of schematic diagram for thrombus elastometer that further embodiment of the present invention provides；
Fig. 5 is a kind of schematic diagram of bracket provided by one embodiment of the present invention；
Fig. 6 is a kind of support schematic diagram including magnet provided by one embodiment of the present invention；
Fig. 7 is a kind of schematic diagram of measuring device provided by one embodiment of the present invention；
Fig. 8 is a kind of application method flow chart of thrombus elastometer provided by one embodiment of the present invention.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments, based on the embodiments of the present invention, those of ordinary skill in the art
Every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
As shown in Figure 1, one embodiment of the invention provides a kind of thrombus elastometer, including：Bracket 101, rotary shaft 102
And position correction apparatus 103；
The bracket 101 is connected with one end of the rotary shaft 102, the bracket 101 be used for the rotary shaft 102 into
Row support, is placed in the other end of the rotary shaft 102 in external tested blood；
The rotary shaft 102 rotates under the driving effect of the tested blood；
The position correction apparatus 103 is connected with the rotary shaft 102, for rotating partially in the rotary shaft 102
When from equilbrium position, the active force for rotating the rotary shaft 102 to the equilbrium position direction is generated.
The present invention provides a kind of thrombus elastometer, rotary shaft can rotate under the support of bracket, position correction apparatus
It is connected with rotary shaft, when rotating deviation equilbrium position under driving effect of the rotary shaft in tested blood, promotes position school
Equipment generates the active force for rotating axial rotary equilbrium position direction.In this way, when tested blood makees the driving of rotary shaft
After removal, if the location of rotary shaft is not equilbrium position, rotary shaft is automatic under the active force of position correction apparatus
It is returned to equilbrium position, without being calibrated by way of manually adjusting to rotary shaft, what rotary shaft was calibrated in saving
Time improves the efficiency detected to blood blood clotting.
In an embodiment of the invention, as shown in Fig. 2, position correction apparatus may include at least one balance spring spring
203, the inner ring of balance spring spring 203 is fixedly connected with the outer circumference surface of rotary shaft 202, and outer ring is fixedly connected with bracket 201.Work as rotation
When shaft 202 is located at equilbrium position, balance spring spring 203 is in free state, does not generate active force to rotary shaft 202, works as rotation
When axis 202 is rotated by the driving effect of tested blood, make balance spring spring 203 that inward turning deformation or outward turning deformation, balance spring occur
Spring 203 generates after deforming restores elastic force, and the effect of the recovery elastic force is to restore rotary shaft 202 to equilbrium position, with
Restore balance spring spring 203 to free state.After activation force of the tested blood to rotary shaft 202 removes, if rotation
The location of axis 202 is not equilbrium position, then rotary shaft 202 is under the recovery elastic force effect of balance spring spring 203 to balance position
The direction rotation set, restores rotary shaft 202 to equilbrium position.
In an embodiment of the invention, when position correction apparatus includes two or more balance spring springs, institute
Have in balance spring spring at least exist the hand of spiral of the balance spring spring from inner ring to outer ring and other balance spring springs from inner ring to
The hand of spiral of outer ring is different.
As described in Figure 3, position correction apparatus includes balance spring spring 3031 and balance spring spring 3032, balance spring spring 3031 and trip
The inner ring of silk spring 3032 is fixed with 302 phase of rotary shaft, and the outer ring of balance spring spring 3031 and balance spring spring 3032 is and bracket
301 phases are fixed, and with observation position shown in Fig. 3, the hand of spiral of the balance spring spring 3031 from inner ring to outer ring is clockwise direction,
The hand of spiral of the balance spring spring 3032 from inner ring to outer ring is the counterclockwise balance spring bullet when rotary shaft 302 rotates counterclockwise
Spring 3031 screws, and when rotary shaft 302 rotates clockwise, balance spring spring 3032 is screwed.
The active force exported when being unfolded due to the force ratio that balance spring spring is exported when being tightened is more stable, will swim
Silk spring is set as the different hand of spiral, when the different direction rotation of axial rotary, always has corresponding balance spring spring to be revolved
Tightly, the active force restored to equilbrium position being provided for rotary shaft, on the one hand such structure keeps the rotation of rotary shaft more steady,
On the other hand it avoids causing balance spring spring to generate plastic deformation by excessive expansion.
In an embodiment of the invention, position correction apparatus further includes at least one zeroing module in addition to balance spring spring,
The corresponding zeroing module of each balance spring spring, module one end of returning to zero are fixed with bracket, the other end in the form of adjustable with it is right
The different location of balance spring spring outer ring is answered to be fixedly connected.
As shown in figure 4, position correction apparatus includes balance spring spring 4031, balance spring spring 4032, balancing controls 4033 and adjusts
Zero device 4034, balance spring spring 4031 is corresponding with balancing controls 4033, and balance spring spring 4032 is corresponding with balancing controls 4034.
One end of balancing controls 4033 is fixedly connected with bracket 401, and the other end passes through the outer ring of a U-shaped structure and balance spring spring 4031
Mutually fixed, the position that outer ring and the U-shaped structure of balance spring spring 4031 are mutually fixed is adjustable；One end of balancing controls 4034 and branch
Frame 401 is fixedly connected, and the other end is mutually fixed by the outer ring of a U-shaped structure and balance spring spring 4032, balance spring spring 4032
Outer ring and the position that U-shaped structure is mutually fixed are adjustable；The inner ring of balance spring spring 4031 and balance spring spring 4032 is and rotary shaft
402 outer circumference surface is mutually fixed.
By adjusting the fixation position on balancing controls 4033 on U-shaped structure and 4031 outer ring of balance spring spring, and zeroing
Fixation position on device 4034 on U-shaped structure and 4032 outer ring of balance spring spring, changes rotary shaft 402 not by external drive
The equilbrium position of rotary shaft 402 is adjusted in the active force that two balance spring springs of masterpiece used time apply rotary shaft 402, realization
It is whole, to be corrected when target position is deviateed in the equilbrium position of rotary shaft 402 to the equilbrium position of rotary shaft 402.
In one embodiment of the invention, as shown in figure 5, bracket includes：Fixed support portion 5011, moveable support portion 5012,
First connecting portion 5013 and second connecting portion 5014.First connecting portion 5013 is fixedly connected with fixed support portion 5011, and second connects
Socket part 5014 is fixedly connected with moveable support portion 5012, with connection between first connecting portion 5013 and second connecting portion 5014
Form is connected, and moveable support portion 5012 is fixedly connected with rotary shaft 502, wherein first connecting portion 5013 and second connecting portion 5014
Between the contact area that is electrically connected be less than preset area, for example, set preset area as 1 square millimeter, first connecting portion 5013
Contact area between second connecting portion 5014 is 0.8 square millimeter.
Fixed support portion 5011 is supported rotary shaft 502 by first connecting portion 5013 and second connecting portion 50141,
When rotary shaft 502 is acted on by external drive, and moveable support portion 5012 is driven to rotate, since first connecting portion 5013 and second connect
The contact area of point contact between socket part 5014 is smaller, and the frictional resistance of generation is accordingly smaller, is revolving to reduce bracket
The rotational resistance that shaft 502 generates when rotating.
In an embodiment of the invention, as shown in figure 5, first connecting portion 5013 can be jewel bearing, correspondingly the
Two interconnecting pieces 5014 are addendum cone, alternatively, first connecting portion 5013 can be addendum cone, correspondingly second connecting portion 5014 is jewel axis
It holds.
Jewel bearing is round pie structure, and conical socket is provided in a plane of round pie structure, and addendum cone is cone
Shape structure.When jewel bearing and addendum cone cooperate, the tip of addendum cone is located in the conical socket on jewel bearing, addendum cone only tip
Area is in contact with jewel bearing.For example, the tip of addendum cone passes through the cone on 0.8 square millimeter of area and jewel bearing
Connected in star realizes point connection.
In an embodiment of the invention, it includes the first magnetic that bracket, which can also include at least a pair of magnet, every a pair of magnet,
Iron and the second magnet, wherein the first magnet is fixed on fixed support portion close to moveable support portion side, the second magnet is fixed on
Close fixed support portion side, the first magnet and the second magnet parallel stacking in moveable support portion, and the same sex magnetic in opposite face
Pole.
As shown in fig. 6, bracket includes a pair of of annular magnet, this includes the first magnet 6015 and the second magnet to annular magnet
6016, wherein the first magnet 6015 is fixed on fixed support portion 6011, the second magnet 6016 is fixed on moveable support portion 6012
On, the axis of the first magnet 6015 is overlapped with the axis of the second magnet 6016, the pole N of the first magnet 6015 and the second magnet 6016
Relatively or the first magnet 6015 is extremely opposite with the S of the second magnet 6016.Due to the first magnet 6015 and the second magnet 6016
Like pole is opposite, generates repulsion between the first magnet 6015 and the second magnet 6016, which can offset a part first
Pressure between interconnecting piece and second connecting portion relatively rotates to further decrease first connecting portion with second connecting portion
Frictional force between time point connection.
As shown in fig. 6, when first connecting portion and second connecting portion are respectively jewel bearing and addendum cone or first connecting portion
And second connecting portion is when being respectively addendum cone and jewel bearing, the axle center and jewel bearing of the first magnet 6015 and the second magnet 6016
And the axle center of addendum cone is overlapped, and the repulsion between the first magnet 6015 and the second magnet 6016 can so be uniformly applied to solid
Determine to prevent moveable support portion 6012 due to force unbalance run-off the straight in support portion 6011 and moveable support portion 6012.
In the use of the new type one embodiment, as shown in figure 5, the thrombus elastometer further includes measuring device 504, measurement
Device 504 can measure the rotational angle of rotary shaft 502, and be corresponded to according to the formation of the rotation angle of rotary shaft 502
The thrombelastogram of tested blood.
In the use of the new type one embodiment, measuring device includes at least one reflecting piece, at least one light emitting
Module, at least one optical receiver module and processing module, the rotary shaft is fixedly connected at least one described reflecting piece, described
Rotary shaft drives at least one reflecting piece rotation under external driving effect；Each described optical transmitter module, for
Fixed direction emits light to corresponding reflecting piece；Each described reflecting piece, for receiving corresponding optical transmitter module transmitting
Light, and the light received is reflected；Each described optical receiver module, it is corresponding reflective for being received with fixed direction
The light of piece reflection, is converted to corresponding electric signal for the light received according to the intensity of light, and by the electric signal transmission to institute
State processing module；The processing module, the electric signal for being converted at least one described optical receiver module are handled, really
The rotational angle of the fixed rotary shaft.Below to include an optical transmitter module, an optical receiver module, a reflecting piece and place
For managing device, the course of work of measuring device is illustrated.
As shown in fig. 7, measuring device includes：Optical transmitter module 7041, optical receiver module 7042, reflecting piece 7043 and processing
Module 7044；
Reflecting piece 7043 is fixed in rotary shaft 702, and rotary shaft 702 can drive reflecting piece 7043 to rotate when rotating；Light
Transmitting module 7041 emits light to reflecting piece 7043 with fixed direction；Reflecting piece 7043 receives what optical transmitter module 7041 emitted
Light, and the light received is reflected；Optical receiver module 7042 receives the light that reflecting piece 7043 emits with fixed direction, and
The light received is converted into corresponding electric signal according to the intensity of the light received, the electric signal transmission that will convert into is to processing
Module 7044；Processing module 7044 according to optical receiver module 7042 transmit come electric signal, determine the rotational angle of rotary shaft.
Since optical transmitter module 7041 emits light to reflecting piece 7043 with fixed direction, driven when rotary shaft 702 rotates
When reflecting piece 7043 rotates, the amount for the light that optical transmitter module 7041 is mapped in reflecting piece 7043 changes, simultaneously because reflective
Piece 7043 rotates, and the optical path of 7043 reflected light of reflecting piece is caused to change；Since optical receiver module 7042 is with fixed
Direction receives the light that reflecting piece 7043 reflects, when the amount for the light that reflecting piece 7043 receives and the optical path of reflected light change
Afterwards, the intensity that reflecting piece 7043 is reflected to the light of optical receiver module 7042 changes；Optical receiver module 7042 will receive
Light is converted to electric signal, and when the intensity of the light received changes, electric signal made of conversion also correspondingly changes.
After electric signal transmission made of optical receiver module 7042 will be converted is to processing module 7044, processing module 7044 into one
Step can determine the electric signal received according to the corresponding relationship of predetermined electric signal size and rotary shaft rotational angle
Corresponding rotary shaft rotational angle forms correspondence as ordinate using the rotational angle of rotary shaft further using the time as abscissa
With the thrombelastogram of tested blood.
In the use of the new type one embodiment, as shown in fig. 7, optical transmitter module 7041 includes light emitting diode 70411
And light-guiding pillar 70412, the light that light emitting diode 70411 issues is through 70412 directive reflecting piece 7043 of light-guiding pillar, light-guiding pillar
Diffusing reflection occurs in the channel of installation diode 70411 for 70412 light that can prevent diode 70411 from issuing, and improves light
The utilization rate of line.
In the use of the new type one embodiment, as shown in fig. 7, optical receiver module 7042 includes photocell 70421 and leads
Light beam 70422, light-guiding pillar 70422 receive the light that reflecting piece 703 reflects, and by the optical transport received to photocell 70421, light
Battery 70421 according to the intensity of light by light-guiding pillar 70422 transmit come light be converted to corresponding electric signal.Pass through light-guiding pillar
70422 conduction reflecting pieces 703 are reflected to the light of photocell 70421, can be to avoid the light that reflecting piece 703 reflects in installation photocell
Diffusing reflection occurs in 70421 channel, influences the intensity for the light that photocell 70421 receives, leads to the rotary shaft 702 determined
Rotational angle inaccuracy, and then the situation of the thrombelastogram finally obtained inaccuracy is caused to occur.
In order to clearly illustrate the structure of thrombus elastometer provided in an embodiment of the present invention, below with reference to shown in Fig. 1
Thrombus elastometer, the application method of the thrombus elastometer is illustrated.
As shown in figure 8, one embodiment of the invention provides a kind of application method of thrombus elastometer, including：
Step 801：The rotary shaft is supported by the bracket, one end of the rotary shaft is made to be placed in tested blood
In liquid；
Step 802：The rotary shaft is driven by tested blood, rotates the rotary shaft；
Step 803：Through the position correction apparatus when the rotary shaft rotates and deviates equilbrium position, generation makes
The rotary shaft is restored to the active force of the equilbrium position.
The embodiment of the invention provides a kind of application methods of thrombus elastometer to be made by being tested blood drive rotary shaft
Rotary shaft rotates, when rotary shaft rotate deviate equilbrium position when, by position correction apparatus generation make rotary shaft restore to
The active force of equilbrium position.In this way, after removing driving effect of the tested blood to rotary shaft, if the location of rotary shaft
It is not equilbrium position, restores rotary shaft to equilbrium position by the active force that position correction apparatus generates, without passing through
The mode manually adjusted calibrates rotary shaft, realizes the automatic calibration of rotary shaft.
In an embodiment of the invention, when the position correction apparatus includes at least one balance spring spring, rotary shaft
When rotation deviates equilbrium position, at least one described balance spring spring is made to screw or be unfolded, at least one described balance spring spring due to
Flexible deformation occurs and generates the active force for rotating axial rotary equilbrium position direction.
In an embodiment of the invention, when the position correction apparatus includes at least two balance spring springs, and at least one
When the hand of spiral of the hand of spiral of a balance spring spring from inner ring to outer ring with other balance spring springs from inner ring to outer ring is opposite, rotation
When shaft rotation deviates equilbrium position, at least one balance spring spring is tightened, and other balance spring springs are unfolded, and makes each balance spring
Spring provides the active force for rotating axial rotary equilbrium position direction.Axial rotary is made by the offer of multiple balance spring springs in this way
The active force of equilbrium position direction rotation, it is ensured that the service life of each balance spring spring, and production when balance spring spring screws
Raw active force is more steady, guarantees smoothly rotate when the rotation of axial rotary different directions.
In an embodiment of the invention, it before being placed in one end of the rotary shaft in tested blood, further wraps
The link position by adjusting each balance spring spring outer ring and balancing controls is included, to adjust rotary shaft not by tested blood drive
The active force that each balance spring spring applies it when effect, to realize the adjusting to balance spring spring balancing position.
In an embodiment of the invention, when the bracket include fixed support portion, moveable support portion, first connecting portion and
When second connecting portion, is connected by the point between first connecting portion and second connecting portion, moveable support is supported by fixed support portion
Portion and rotary shaft.In this way, since the contact area of the point connection between first connecting portion and second connecting portion is less than preset area,
Lesser contact area can reduce the frictional force generated when first connecting portion and second connecting portion relative rotation, to reduce branch
Frame influences caused by rotating on rotary shaft, improves the accuracy of measurement result.
In an embodiment of the invention, when first connecting portion includes jewel bearing, and second connecting portion includes addendum cone, lead to
Fixed support portion support jewel bearing is crossed, addendum cone is supported in the form of the point connection jewel bearing, is supported by addendum cone
Moveable support portion and the rotary shaft being fixedly connected with moveable support portion.Due to jewel bearing hardness with higher, and with point
The form of connection is connected with addendum cone, the frictional force that bracket generates it when reducing rotary shaft rotation.
In an embodiment of the invention, when first connecting portion includes addendum cone, and second connecting portion includes jewel bearing, lead to
Fixed support portion support addendum cone is crossed, jewel bearing is supported in the form of the point connection addendum cone, is supported by jewel bearing
Moveable support portion and the rotary shaft being fixedly connected with moveable support portion.During practical business is realized, jewel bearing is consolidated
Due on fixed support portion or being fixed in moveable support portion, flexible choice can be carried out according to installation space and specific requirements.
In an embodiment of the invention, when bracket includes at least a pair of magnet, by being fixed on fixed support portion
The first magnet repulsion is applied to the second magnet for being fixed in moveable support portion, reduce first connecting portion and second connecting portion it
Between pressure, thus further decrease between first connecting portion and second connecting portion put junction generate frictional force.
In an embodiment of the invention, when thrombus elastometer includes measuring device, by the measuring device to rotation
The rotational angle of axis measures, and the thrombelastogram for corresponding to tested blood is formed according to the rotational angle of rotary shaft.
In an embodiment of the invention, when measuring device includes at least one optical transmitter module, at least one light-receiving
When module, at least one reflecting piece and processing module, by optical transmitter module described in each with fixed direction to corresponding
Reflecting piece reflected light rotates the rotary shaft by external drive, and the rotary shaft is made to drive at least one described reflecting piece
Rotation, the light of corresponding optical transmitter module transmitting is received by reflecting piece described in each, and is reflected the light received, is led to
It crosses each described optical receiver module and receives the light of corresponding reflecting piece reflection with fixed direction, and will be connect according to the intensity of light
The light received is converted to corresponding electric signal, the electric signal that each optical receiver module is converted by the processor into
Row processing, determines the rotational angle of the rotary shaft.
As shown in fig. 7, optical transmitter module 7041 is emitted to instead when rotary shaft 702 rotates and reflecting piece 7043 is driven to rotate
The amount of light on mating plate 7043 changes, and the optical path that reflecting piece 7043 rotates back reflection light also changes, and causes to be reflected into
The intensity of light on optical receiver module 7042 changes, intensity of the optical receiver module 7042 according to the light received, formation pair
The electric signal answered determines corresponding time rotary shaft 702 according to the corresponding relationship of electric signal size and rotary shaft rotational angle
Rotational angle, according to the rotational angle of each time rotary shaft 702, using the time as abscissa, with the rotational angle of rotary shaft 702
For ordinate, the thrombelastogram for corresponding to tested blood is formed.
In an embodiment of the invention, when optical transmitter module includes light emitting diode and light-guiding pillar, optical transmitter module
To reflecting piece transmitting light process may include：To corresponding reflecting piece light occurs for light emitting diode by light-guiding pillar.By leading
When to reflecting piece light occurs for light beam, light is propagated in light-guiding pillar, and mode light generates unrestrained anti-in the channel of installation light emitting diode
It penetrates, improves the utilization rate of light.
In an embodiment of the invention, when optical receiver module includes photocell and light-guiding pillar, optical receiver module is received
The process of the light of corresponding reflecting piece reflection may include：Light-guiding pillar receives the light of corresponding reflecting piece reflection, and the light that will be received
It is transferred to photocell.To photocell, the light that can be reflected to avoid reflecting piece exists the optical transport for being reflected reflecting piece by light-guiding pillar
Generation diffusing reflection is installed in photronic channel, cause part light cannot reach photocell and caused by error, improve to rotation
The accuracy that shaft rotational angle is detected.
Each embodiment provided by the invention, at least has the advantages that：
1, in the embodiment of the present invention, rotary shaft can rotate under the support of bracket, position correction apparatus and rotary shaft phase
Even, when rotating deviation equilbrium position under driving effect of the rotary shaft in tested blood, position correction apparatus is promoted to generate
The active force for rotating axial rotary equilbrium position direction.In this way, after driving effect of the tested blood to rotary shaft removes, such as
The location of fruit rotary shaft is not equilbrium position, and rotary shaft automatically reverts to balance position under the active force of position correction apparatus
It sets, without calibrating by way of manually adjusting to rotary shaft, saves the time calibrated to rotary shaft, improve pair
The efficiency that blood blood clotting is detected.
2, in the embodiment of the present invention, position correction apparatus may include at least one balance spring spring, the inner ring of balance spring spring
It is fixedly connected with rotary shaft, the outer ring of balance spring spring is fixedly connected with bracket, makes to swim when rotary shaft, which rotates, deviates equilbrium position
Silk spring deforms, and the elastic force that balance spring camber of spring generates acts in rotary shaft, and the action direction of the elastic force is to make to rotate
Axis restores to the direction of equilbrium position.Since balance spring spring-mass is relatively light and is quick on the draw, using balance spring spring as position school
Equipment can reduce the resistance received when the inertia for selecting axis and rotation, improve the accuracy of thrombus elastometer.
3, in the embodiment of the present invention, position correction apparatus may include multiple balance spring springs, one in all balance spring springs
Divide the hand of spiral of balance spring spring from the hand of spiral of other balance spring springs on the contrary, the direction for keeping axial rotary different is equal when rotating
There is part balance spring spring to be tightened, such structure can extend the service life of balance spring spring, and guarantee that rotary shaft can be put down
Steady rotation.
4, in the embodiment of the present invention, balance spring spring is mutually fixed by the module that returns to zero with bracket, zeroing module and balance spring spring
The link position of outer ring is adjustable, thus by the link position of adjusting zeroing module and balance spring spring outer ring to rotary shaft
Equilbrium position is adjusted, and is calibrated with the equilbrium position to rotary shaft, and the ease for use of thrombus elastometer is improved.
5, in the embodiment of the present invention, it is connected between fixed support portion and moveable support portion by jewel bearing and addendum cone, it is precious
It is point connection between stone bearing and addendum cone, since contact area is smaller, jewel bearing and the friction generated when addendum cone relative rotation
Power is smaller, so that the resistance that bracket generates rotary shaft rotation is relatively small, so that rotary shaft can be under lesser driving force
It can rotate, improve the sensitivity and accuracy of thrombus elastometer.
6, in the embodiment of the present invention, by the rotational angle of optical signal detecting rotary shaft, due to the stability of optical signal, no
It is influenced by factors such as temperature, is compared compared with the existing technology by the rotational angle of resistance detection rotary shaft, be can be improved pair
The accuracy that rotary shaft rotational angle is detected is further ensured that the accuracy of blood Blood coagulation test.
It should be noted that, in this document, such as first and second etc relational terms are used merely to an entity
Or operation is distinguished with another entity or operation, is existed without necessarily requiring or implying between these entities or operation
Any actual relationship or order.Moreover, the terms "include", "comprise" or its any other variant be intended to it is non-
It is exclusive to include, so that the process, method, article or equipment for including a series of elements not only includes those elements,
It but also including other elements that are not explicitly listed, or further include solid by this process, method, article or equipment
Some elements.In the absence of more restrictions, the element limited by sentence " including one ", it is not excluded that including described
There is also other identical factors in the process, method, article or equipment of element.
Finally, it should be noted that：The foregoing is merely presently preferred embodiments of the present invention, is merely to illustrate skill of the invention
Art scheme, is not intended to limit the scope of the present invention.Any modification for being made all within the spirits and principles of the present invention,
Equivalent replacement, improvement etc., are included within the scope of protection of the present invention.
Claims (7)
1. a kind of thrombus elastometer, which is characterized in that including：Bracket, rotary shaft and position correction apparatus；
The bracket is connected with one end of the rotary shaft, and the bracket makes the rotation for being supported to the rotary shaft
The other end of shaft is placed in external tested blood；
The rotary shaft rotates under the driving effect of the tested blood；
The position correction apparatus is connected with the rotary shaft, for when the rotary shaft rotates and deviates equilbrium position,
The active force for rotating equilbrium position direction described in the axial rotary is generated,
The bracket includes：Fixed support portion, moveable support portion, first connecting portion and second connecting portion；
The first connecting portion is fixedly connected with the fixed support portion, and the second connecting portion is fixed with the moveable support portion
Connection；
The first connecting portion is connected in the form of point contact with the second connecting portion, wherein the contact area of the point contact
Less than preset area；
The moveable support portion is fixedly connected with one end of the rotary shaft,
The position correction apparatus includes：At least two balance spring springs；
The inner ring of each balance spring spring is fixedly connected with the outer circumference surface of the rotary shaft；
The outer ring of each balance spring spring is fixedly connected with the bracket；
The hand of spiral of at least one balance spring spring from inner ring to outer ring and other balance springs in at least two balance springs spring
The hand of spiral of the spring from inner ring to outer ring is opposite.
2. thrombus elastometer according to claim 1, which is characterized in that the position correction apparatus further comprises：Extremely
A few zeroing module, wherein each corresponding balance spring spring of zeroing module；
Each zeroing module one end be fixedly connected with the bracket, the other end in the form of adjustable with corresponding balance spring bullet
The different location of spring outer ring is fixedly connected, the equilbrium position to be adjusted.
3. thrombus elastometer according to claim 1, which is characterized in that
The first connecting portion includes：Jewel bearing, the second connecting portion include：Addendum cone；
Or,
The first connecting portion includes：Addendum cone, the second connecting portion include：Jewel bearing；
Wherein, the jewel bearing is round pie structure, is provided with conical socket in a plane of round pie structure, described
Addendum cone is cone structure, and the tip of the addendum cone is located in the conical socket on the jewel bearing, the addendum cone and the treasured
Stone bearing is connected in the form of the point contact that contact area is less than the preset area.
4. thrombus elastometer according to claim 1, which is characterized in that
The bracket further comprises：At least a pair of magnet；
It is directed to every a pair of magnet, this is fixed on the fixed support portion close to the movable branch the first magnet in magnet
Support part side, this is fixed in the moveable support portion close to the fixed support portion side the second magnet in magnet；
First magnet and the second magnet parallel stacking, and two faces being close are like pole.
5. according to claim 1 to any thrombus elastometer in 4, which is characterized in that further comprise：Measuring device；
The measuring device is measured for the rotational angle to the rotary shaft, and according to the angle of rotation of the rotary shaft
Degree forms the thrombelastogram for corresponding to the tested blood.
6. thrombus elastometer according to claim 5, which is characterized in that
The measuring device includes：At least one reflecting piece, at least one optical transmitter module, at least one optical receiver module and place
Manage module；
The rotary shaft is fixedly connected at least one described reflecting piece, described in the rotary shaft drives under external driving effect
The rotation of at least one reflecting piece；
Each described optical transmitter module, for emitting light to corresponding reflecting piece with fixed direction；
Each described reflecting piece for receiving the light of corresponding optical transmitter module transmitting, and reflects the light received；
Each described optical receiver module, for receiving the light of corresponding reflecting piece reflection with fixed direction, according to the strong of light
The light received is converted to corresponding electric signal by degree, and gives the electric signal transmission to the processing module；
The processing module, the electric signal for being converted at least one described optical receiver module are handled, described in determination
The rotational angle of rotary shaft.
7. thrombus elastometer according to claim 6, which is characterized in that
The optical transmitter module includes：Light emitting diode and light-guiding pillar, wherein the light emitting diode by the light-guiding pillar to
The reflecting piece emits light；
And/or
The optical receiver module includes：Photocell and light-guiding pillar, wherein the photocell is received described anti-by the light-guiding pillar
The light of mating plate transmitting.
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610278393.1A CN105807039B (en) | 2016-04-29 | 2016-04-29 | Thrombus elastometer |
| JP2019507986A JP6964656B2 (en) | 2016-04-29 | 2017-05-02 | Brackets, support systems, thromboelast graphs and how to use them |
| PCT/CN2017/082775 WO2017186186A1 (en) | 2016-04-29 | 2017-05-02 | Thrombelastograph analyser and method for detecting rotation angle of rotating shaft |
| PCT/CN2017/082786 WO2017186190A1 (en) | 2016-04-29 | 2017-05-02 | Bracket, support system, and thrombelastography device and use method thereof |
| EP17788837.7A EP3450977B1 (en) | 2016-04-29 | 2017-05-02 | Apparatus for measuring blood coagulation data, and use method, connection member and support thereof |
| JP2019507983A JP2019516115A (en) | 2016-04-29 | 2017-05-02 | Blood coagulation data detection device, method of using the same, connection member and bracket |
| PCT/CN2017/082785 WO2017186189A1 (en) | 2016-04-29 | 2017-05-02 | Cap removal device, and thrombelastography device having same |
| US16/097,016 US11067490B2 (en) | 2016-04-29 | 2017-05-02 | Bracket, support system, and thrombelastography device and use method thereof |
| US16/097,570 US10801939B2 (en) | 2016-04-29 | 2017-05-02 | Apparatus for measuring blood coagulation data and use method thereof, connection member and support |
| PCT/CN2017/082757 WO2017186185A1 (en) | 2016-04-29 | 2017-05-02 | Apparatus for measuring blood coagulation data, and use method, connection member and support thereof |
| PCT/CN2017/082777 WO2017186187A1 (en) | 2016-04-29 | 2017-05-02 | Thrombelastography device, heating apparatus, blood coagulation analysis system, and rotational angle measurement method |
| JP2019507985A JP6924257B2 (en) | 2016-04-29 | 2017-05-02 | A lid removal device and a thromboelast graph equipped with the device |
| EP21209996.4A EP4019969A3 (en) | 2016-04-29 | 2017-05-02 | Cap removal device, and thrombelastography device having same |
| US16/096,956 US11366094B2 (en) | 2016-04-29 | 2017-05-02 | Thrombelastography device, heating apparatus, blood coagulation analysis system and rotational angle measurement method |
| EP17788841.9A EP3450983B1 (en) | 2016-04-29 | 2017-05-02 | Thrombelastography device comprising cap removal device |
| US16/097,556 US10759642B2 (en) | 2016-04-29 | 2017-05-02 | Cap removal device and thrombelastography device having same |
| US17/006,535 US11866311B2 (en) | 2016-04-29 | 2020-08-28 | Cap removal device and thrombelastography device having same |
| JP2022035646A JP7383743B2 (en) | 2016-04-29 | 2022-03-08 | Blood coagulation data measuring device, method of use thereof, connecting member and support body |
| US17/748,679 US11927587B2 (en) | 2016-04-29 | 2022-05-19 | Thrombelastography device, heating apparatus, blood coagulation analysis system and rotational angle measurement method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610278393.1A CN105807039B (en) | 2016-04-29 | 2016-04-29 | Thrombus elastometer |
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| Publication Number | Publication Date |
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| CN105807039A CN105807039A (en) | 2016-07-27 |
| CN105807039B true CN105807039B (en) | 2018-11-23 |
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| CN201610278393.1A Active CN105807039B (en) | 2016-04-29 | 2016-04-29 | Thrombus elastometer |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11016013B2 (en) | 2016-04-29 | 2021-05-25 | Neotek Bioscience Co., Ltd. | Apparatus for measuring blood coagulation data, and use method and calibration method thereof |
| WO2017186190A1 (en) * | 2016-04-29 | 2017-11-02 | 诺泰科生物科技（苏州）有限公司 | Bracket, support system, and thrombelastography device and use method thereof |
| WO2017186185A1 (en) * | 2016-04-29 | 2017-11-02 | 诺泰科生物科技（苏州）有限公司 | Apparatus for measuring blood coagulation data, and use method, connection member and support thereof |
| CN106404888A (en) * | 2016-08-30 | 2017-02-15 | 诺泰科生物科技（苏州）有限公司 | Thromboelastography instrument and use method thereof |
| CN106442702A (en) * | 2016-08-30 | 2017-02-22 | 诺泰科生物科技（苏州）有限公司 | Thrombelastograph coagulation analyzer and application method thereof |
| WO2018043420A1 (en) * | 2016-08-29 | 2018-03-08 | 藤森工業株式会社 | Blood coagulation test device and blood coagulation test method |
| CN107505454A (en) * | 2017-06-23 | 2017-12-22 | 世纪亿康（天津）医疗科技发展有限公司 | Reaction system for detecting blood coagulation and platelet functions and application thereof |
| CN108562731A (en) * | 2018-06-19 | 2018-09-21 | 重庆南方数控设备有限责任公司 | A kind of prover of calibration thrombelastogram instrument sense channel |
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