CN105797023A - Application of traditional Chinese medicine in preparation of medicine for treating primary liver cancer - Google Patents

Application of traditional Chinese medicine in preparation of medicine for treating primary liver cancer Download PDF

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Publication number
CN105797023A
CN105797023A CN201610217746.7A CN201610217746A CN105797023A CN 105797023 A CN105797023 A CN 105797023A CN 201610217746 A CN201610217746 A CN 201610217746A CN 105797023 A CN105797023 A CN 105797023A
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chinese medicine
parts
medicine
herba
traditional chinese
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刘学键
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Yantai Lanyangzhicao Pharmaceutical Biotechnology Co Ltd
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Yantai Lanyangzhicao Pharmaceutical Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/902Sparganiaceae (Bur-reed family)

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and relates to an application of a traditional Chinese medicine in preparation of a medicine for treating primary liver cancer. The traditional Chinese medicine is prepared from raw materials as follows: Japanese dock roots, vinegar-processed common burreed rhizomes, virgate wormwood herbs, barbated skullcup herbs, polyporus umbellatus, vietnamese sophora roots, yerbadetajo herbs, tree peony bark and suberect spatholobus stems. The medicines are used cooperatively, and accordingly, the traditional Chinese medicine has effects of activating the blood circulation, removing stasis, clearing heat, removing toxicity, soothing the liver, relieving depression, nourishing the liver and the kidney, eliminating the abdominal mass and activating meridians to stop pains. The traditional Chinese medicine can inhibit the tumor growth, improve clinical symptoms of patients and prolong the lifetime of the patients, thereby effectively curing the liver cancer and having a curing effect on the early liver cancer.

Description

A kind of Chinese medicine purposes in the medicine of preparation treatment primary hepatocarcinoma
Technical field
The present invention relates to a kind of Chinese medicine purposes in the medicine of preparation treatment primary hepatocarcinoma, belong to technical field of Chinese medicines.
Background technology
Hepatocarcinoma is a kind of malignant tumor betiding liver.Having constitutional and Secondary cases two kinds, for one of China's common disease, its sickness rate accounts for the 3rd in male tumor, and women accounts for the 5th.The current cause of disease is unclear, it is considered to chronic hepatitis, chemical carcinogen, parasitic disease, trophic factor, drink and inherited genetic factors etc. is relevant.Primary hepatocarcinoma originates from hepatocyte or bile duct cell;Secondary liver cancer mostly is the transfer of malignant tumor of digestive tract, and tumor can be limited to or disperse.Primary disease early symptom is inconspicuous, lacks special sign.The signs such as can having upper abdomen or hepatalgia, upper abdomen distension, lump, stomach poor appetite moves back, and is off one's feed, and loses weight, heating, jaundice, liver palm, spider angioma.
Excision and chemicotherapy are the methods of traditional treatment hepatocarcinoma, aforesaid way is very big to the injury of human body, defective property, wherein only early stage patient just can carry out operative treatment, Radiotherapy chemotherapy can effectively kill cancerous cell, but normal cell can be killed again simultaneously and cause that the immunologic function of patient is suppressed, and more complication occurs.
The traditional Chinese medical science thinks that hepatocarcinoma belongs to the categories such as " the liver rump ", " abdominal mass ", " gathering ", " tympanites ", " mass at the hypochondrium ", " jaundice ", and primary disease is mainly lost by internal organs asthenia of qi and blood, insufficiency of the spleen wet poly-, the expectorant blood coagulation stasis of blood;Six climate exopathogens heresy poison is invaded, evil solidifying poison knot, internal injury caused by excess of seven emotions, depressed emotion etc., and gas, blood, wet, heat, the stasis of blood, poison can be made to tie mutually and form hepatocarcinoma.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine purposes in the medicine of preparation treatment primary hepatocarcinoma, and this Chinese medicine is to human non-toxic's side effect, and effective percentage is high, can significantly extend the survival of patients phase.
The technical solution used in the present invention is: a kind of Chinese medicine treating primary hepatocarcinoma, is made up of following raw material medicaments: Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi.
Preferably, a kind of Chinese medicine treating primary hepatocarcinoma, is made up of the crude drug of following weight parts: Radix Rumicis Japonici 10-30 part, stir-baked RHIZOMA SPARGANII with vinegar 5-12 part, Herba Artemisiae Scopariae 5-12 part, Herba Scutellariae Barbatae 10-30 part, Polyporus 5-12 part, Radix Sophorae Tonkinensis 10-30 part, Herba Ecliptae 10-30 part, Cortex Moutan 5-12 part, Caulis Spatholobi 10-30 part.
Preferably, a kind of Chinese medicine treating primary hepatocarcinoma, it is made up of the crude drug of following weight parts: 20 parts of Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar 8 parts, Herba Artemisiae Scopariae 8 parts, Herba Scutellariae Barbatae 20 parts, Polyporus 6 parts, Radix Sophorae Tonkinensis 20 parts, Herba Ecliptae 20 parts, Cortex Moutan 6 parts, Caulis Spatholobi 20 parts.
Preferably, a kind of Chinese medicine treating primary hepatocarcinoma, it is made up of the crude drug of following weight parts: 30 parts of Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar 8 parts, Herba Artemisiae Scopariae 12 parts, Herba Scutellariae Barbatae 24 parts, Polyporus 12 parts, Radix Sophorae Tonkinensis 24 parts, Herba Ecliptae 28 parts, Cortex Moutan 6 parts, Caulis Spatholobi 24 parts.
The pharmacological action of each Chinese medicine:
Radix Rumicis Japonici: for the root of polygonaceae plant Radix Rumicis Japonici or Nepal's Radix Rumicis Japonici.Nature and flavor: bitter, cold in nature;Gui Jing: the heart, liver, large intestine channel;Function cures mainly: clearing away heat and loosing the bowels, cooling blood for hemostasis, killing parasites for relieving itching.Main constipation, hematemesis and epistaxis, discharging fresh blood stool, hemorrhoidal bleeding, metrorrhagia, scabies, bald in vain, ulcerative carbuncle toxic swelling, traumatic injury.
Stir-baked RHIZOMA SPARGANII with vinegar: nature and flavor: pungent, bitter is flat;Gui Jing: return liver, spleen channel;Function cures mainly: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.
Herba Artemisiae Scopariae: nature and flavor: bitter, pungent, is slightly cold;Gui Jing: return spleen, stomach, liver, gallbladder meridian;Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus;Infectious jaundice type hepatitis.
Herba Scutellariae Barbatae: nature and flavor: pungent, bitter, cold;Gui Jing: return lung, liver, kidney channel;Function cures mainly: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, fall and flutter the pain of injury, edema, jaundice.
Polyporus: nature and flavor: sweet, light, flat;Gui Jing: return kidney, bladder warp;Function cures mainly: promoting diuresis to eliminate damp pathogen.For dysuria, edema, have loose bowels, stranguria with turbid discharge, leukorrhagia.
Radix Sophorae Tonkinensis: nature and flavor: bitter, cold, poisonous;Gui Jing: attach to the lung and stomach meridians;Function cures mainly: heat-clearing and toxic substances removing, sore-throat relieving of subsiding a swelling.Pent up for fire-toxin, laryngopharynx swelling and pain, gingivitis.
Herba Ecliptae: nature and flavor: sweet, sour, cold;Gui Jing: return kidney, Liver Channel;Function cures mainly: nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Cortex Moutan: nature and flavor: bitter, pungent, is slightly cold;Gui Jing: GUIXIN, liver, kidney channel;Function cures mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, fall and flutter the pain of injury.
Caulis Spatholobi: nature and flavor: bitter, sweet, temperature;Gui Jing: return liver, kidney channel;Function cures mainly: enrich blood, and invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
A kind of method that present invention also offers Chinese medicine preparing treatment primary hepatocarcinoma, comprises the following steps:
Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi are ground into fine powder, and sieve 80-100 order, mixing.Chinese medicine preparation is prepared into, such as the acceptable dosage form clinically such as pill, granule, tablet or capsule with pharmaceutically acceptable carrier.
Preferably, form of Chinese drug of the present invention is big honeyed pills.
A kind of method that present invention also offers Chinese medicine big honeyed pills preparing treatment primary hepatocarcinoma, comprise the following steps: Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi are ground into fine powder, sieve 80-100 order, mixing, every 100g powder adds refined honey 150-160g, make big honeyed pills, to obtain final product.
Said medicine can play blood circulation promoting and blood stasis dispelling with the use of, traditional Chinese medical science angle, heat-clearing and toxic substances removing, soothing liver-QI for relieving depression, nourishing the liver and kidney, eliminating mass abdominal mass, removing obstruction in the collateral to relieve pain effect.Doctor trained in Western medicine angle adjustable immunity of organism, it is suppressed that growth of cancer cells, cancer cell specific induction of apoptosis breaks up, the biosynthesis of interference cancerous cell DNA, RAN, Pr, it is suppressed that hepatoma Metastasis recurrence etc. reaches to prevent and treat the purpose of hepatocarcinoma.Tumor growth can be suppressed through the clinical trial certificate Chinese medicine of the present invention that inventor is long-term, improve the clinical symptoms of patient, extend the survival of patients phase, thus effectively treating hepatocarcinoma, and early hepatocarcinoma being had healing effect.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1:
Prescription (with listed as parts by weight): 20 parts of Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar 8 parts, Herba Artemisiae Scopariae 8 parts, Herba Scutellariae Barbatae 20 parts, Polyporus 6 parts, Radix Sophorae Tonkinensis 20 parts, Herba Ecliptae 20 parts, Cortex Moutan 6 parts, Caulis Spatholobi 20 parts.
Method for making: Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi are ground into fine powder, sieve 100 orders, and mixing, every 100g powder adds refined honey 150g, makes big honeyed pills, every ball 4g, to obtain final product.
Embodiment 2:
Prescription (with listed as parts by weight): 30 parts of Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar 8 parts, Herba Artemisiae Scopariae 12 parts, Herba Scutellariae Barbatae 24 parts, Polyporus 12 parts, Radix Sophorae Tonkinensis 24 parts, Herba Ecliptae 28 parts, Cortex Moutan 6 parts, Caulis Spatholobi 24 parts.
Method for making: Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi are ground into fine powder, sieve 100 orders, and mixing, every 100g powder adds refined honey 150g, makes big honeyed pills, every ball 4g, to obtain final product.
Embodiment 3:
Prescription (with listed as parts by weight): 12 parts of Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar 12 parts, Herba Artemisiae Scopariae 12 parts, Herba Scutellariae Barbatae 12 parts, Polyporus 6 parts, Radix Sophorae Tonkinensis 12 parts, Herba Ecliptae 24 parts, Cortex Moutan 6 parts, Caulis Spatholobi 12 parts.
Method for making: Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi are ground into fine powder, sieve 100 orders, and mixing, every 100g powder adds refined honey 150g, makes big honeyed pills, every ball 4g, to obtain final product.
Embodiment 4:
Prescription (with listed as parts by weight): 12 parts of Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar 6 parts, Herba Artemisiae Scopariae 6 parts, Herba Scutellariae Barbatae 12 parts, Polyporus 12 parts, Radix Sophorae Tonkinensis 12 parts, Herba Ecliptae 12 parts, Cortex Moutan 6 parts, Caulis Spatholobi 12 parts.
Method for making: Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi are ground into fine powder, sieve 80 orders, and mixing, every 100g powder adds refined honey 160g, makes big honeyed pills, every ball 4g, to obtain final product.
Test example 1: treatment hepatocarcinoma test
1.1 test materials
Trial drug:
The embodiment of the present invention 1, embodiment 2 prescriptions of Chinese medicine.Method for making: Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi are ground into fine powder, sieve 100 orders, mixing.
Experimental animal:
KM (Kunming) mice, SPF level 80,4 week old, male and female dual-purpose, body weight 20-25g, animal housing of Beijing University of Chinese Medicine carries.Standard feed and water is adopted to raise.
Test tumor strain: H22 hepatoma cell strain.
1.2 test methods:
In mice right limb oxter inoculation, the ascites 0.1ml generated after rat liver cancer H22,1:4 diluent.Within 4 days, become tumor, after becoming tumor, be randomly divided into four groups (normal saline group, the embodiment of the present invention 1 group, the embodiment of the present invention 2 groups, dehydrated alcohol groups), often group 20.Give normal saline, the embodiment of the present invention 1 prescription Chinese medicine powder, the embodiment of the present invention 2 prescription Chinese medicine powder, dehydrated alcohol respectively, intratumor injection, 1 time/d, totally 4 times.Put to death mice after 4 days, peel off tumor tissues, weigh, calculate tumour inhibiting rate.Tumour inhibiting rate=(matched group tumor weight-experimental group tumor weight)/matched group tumor weight.
Label taking originally does pathology detection, and does histochemistry [lactic acid dehydrogenase (LDH), succinate dehydrogenase (SDH)] dyeing and SABC (bcl-2), and (Bax, c-myc) dyes.
Statistic software SPSS 19.0 is utilized to carry out F inspection.
1.3 result of the tests
Respectively organize the death condition of mice over the course for the treatment of, normal saline group dead mouse 9,1 group of dead mouse of the embodiment of the present invention 1,2 groups of dead mouses of the embodiment of the present invention 1, dehydrated alcohol group dead mouse 6.
1.3.1 respectively organize in Mice Body and press down cancer situation in Table 1.
Tumor suppression results contrast in Mice Body respectively organized by table 1
Compare with normal saline group,*P < 0.01;Compare with dehydrated alcohol group,P < 0.01.
1.3.2 mice LDH, SDH expression is respectively organized in Table 2.
Mice LDH, SDH expression of results of respectively organizing table 2 compare ()
Compare with normal saline group,*P < 0.05;Compare with dehydrated alcohol group,&P < 0.05.
1.4 conclusions
Chinese medicine of the present invention can obviously reduce mouse death rate, extends survival time of mice.All see under pathology detection result light microscopic that each group of mouse spleen has a small amount of or volume multinucleated giant cell, the heart, lung, kidney Non Apparent Abnormality.The embodiment of the present invention 1 group, the embodiment of the present invention 2 groups, the visible focal necrosis of dehydrated alcohol group mouse liver cell.Illustrate that hepatoma carcinoma cell is had obvious inhibitory action by the present invention.
Test example 2: clinical trial
2.1 case selections
Clinical patients: select to be diagnosed as patient 120 example of hepatocarcinoma, all cases are all clarified a diagnosis through pathological diagnosis or AFP mensuration, imaging examination etc. and are diagnosed as hepatocarcinoma, diagnostic criteria is drafted with reference to " new Chinese medicine guideline of clinical investigations " version, " Chinese Internal Medicine ", " internal medicine teaching material the 8th edition " relevant content in 1993, and all cases is all through laboratory, B ultrasonic, the modern detection method such as CT does auxiliary diagnosis if desired.
Wherein the oldest person 62 years old, reckling 28 years old, 50.8 years old mean age;Hepatocarcinoma I phase patient 12 example, hepatocarcinoma II phase patient 44 example, hepatocarcinoma III phase patient 64 example.Clinical manifestation, part has stomach poor appetite to move back, dyspepsia and diarrhoea, and part has asthenia universalis, mass in the abdomen under rib, gastral cavity abdomen side of body rib distension, and lack of appetite is felt sick, and notably vomits, and poor appetite is weak, emaciated physique, dimly red tongue or have ecchymosis petechia, white and thin fur, the profound disease such as tightly of arteries and veins.
2.2 curative effect determinate standards
Complete incidence graph: tumor tissues is wholly absent, serum alpha-fetoprotein was recovered to normal range;
Partial rcsponse: tumor tissues reduces more than 50%, serum alpha-fetoprotein was recovered to normal range;
Stable: tumor tissues reduces or increases equal to 25%;
Worsen: tumor tissues increases more than 25%.
2.3 Therapeutic Method
All patients are equally divided into two groups by statistical method, often group patient 60 example, wherein hepatocarcinoma I phase patient 6 example, hepatocarcinoma II phase patient 22 example, hepatocarcinoma III phase patient 32 example.Two groups of patients give the embodiment of the present invention 1 respectively, the big honeyed pills of embodiment 2 preparation is treated, and every day 3 times, each 2,30 days be a course for the treatment of.
2.4 result of the tests
Table 3 clinical test results
After the treatment of 3 courses for the treatment of of medicine of the present invention, embodiment 1 group, embodiment 2 groups have 20,19 patient's complete incidence graph (wherein the I whole complete incidence graph of phase liver cancer patient) respectively, account for the 33.3% of total case load, 31.7% respectively;Partial rcsponse is 25,24 examples, accounts for the 41.7% of total case load, 40.0% respectively;Stablize 14,16 examples, account for the 23.3% of total case load, 26.7% respectively;Worsen 1 example, account for the 1.7% of total case load.Total effective rate is 98.3%.
Clinical symptoms improvement aspect, embodiment 1 group, 2 groups of hepatalgia improvement rates of embodiment respectively 90.0%, 88.3%, fatigue and weak improvement rate respectively 80.0%, 78.3%, inappetence improvement rate is 78.3%.Meanwhile, liver cancer patient has been carried out blood, urine, feces routine examination, the heart, Liver and kidney function inspection by this research, does not all find obvious adverse reaction and toxic and side effects.Prompting this law Clinical practice is safe and reliable.
Although, above the present invention is described in detail with a general description of the specific embodiments, but on basis of the present invention, it is possible to it is made some modifications or improvements, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.

Claims (5)

1. a Chinese medicine treats the purposes in the medicine of primary hepatocarcinoma in preparation, it is characterised in that described Chinese medicine is made up of following raw material medicaments: Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi.
2. Chinese medicine treats the purposes in the medicine of primary hepatocarcinoma in preparation according to claim 1, it is characterized in that, described Chinese medicine is made up of the crude drug of following weight parts: Radix Rumicis Japonici 10-30 part, stir-baked RHIZOMA SPARGANII with vinegar 5-12 part, Herba Artemisiae Scopariae 5-12 part, Herba Scutellariae Barbatae 10-30 part, Polyporus 5-12 part, Radix Sophorae Tonkinensis 10-30 part, Herba Ecliptae 10-30 part, Cortex Moutan 5-12 part, Caulis Spatholobi 10-30 part.
3. Chinese medicine treats the purposes in the medicine of primary hepatocarcinoma in preparation according to claim 2, it is characterized in that, described Chinese medicine is made up of the crude drug of following weight parts: 20 parts of Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar 8 parts, Herba Artemisiae Scopariae 8 parts, Herba Scutellariae Barbatae 20 parts, Polyporus 6 parts, Radix Sophorae Tonkinensis 20 parts, Herba Ecliptae 20 parts, Cortex Moutan 6 parts, Caulis Spatholobi 20 parts.
4. the purposes in the medicine of preparation treatment primary hepatocarcinoma of the Chinese medicine according to any one of claim 1-3, it is characterised in that described Chinese medicine is prepared from by following methods:
Radix Rumicis Japonici, stir-baked RHIZOMA SPARGANII with vinegar, Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Polyporus, Radix Sophorae Tonkinensis, Herba Ecliptae, Cortex Moutan, Caulis Spatholobi are ground into fine powder, and sieve 80-100 order, mixing, prepares into Chinese medicine preparation with pharmaceutically acceptable carrier.
5. the Chinese medicine according to claim 4 purposes in the medicine of preparation treatment primary hepatocarcinoma, it is characterised in that: described Chinese medicine preparation is pill, granule, tablet or capsule.
CN201610217746.7A 2016-04-11 2016-04-11 Application of traditional Chinese medicine in preparation of medicine for treating primary liver cancer Withdrawn CN105797023A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107252471A (en) * 2017-06-10 2017-10-17 刘进池 Treat the pill of primary carcinoma of liver

Citations (3)

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