CN105796867A - Throat heat clearing granules and preparation method thereof - Google Patents
Throat heat clearing granules and preparation method thereof Download PDFInfo
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- CN105796867A CN105796867A CN201610220751.3A CN201610220751A CN105796867A CN 105796867 A CN105796867 A CN 105796867A CN 201610220751 A CN201610220751 A CN 201610220751A CN 105796867 A CN105796867 A CN 105796867A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses throat heat clearing granules prepared from extracts of raw materials and auxiliary materials. The raw materials comprise 15-25 parts of figwort roots by weight, 15-25 parts of dwarf lilyturf tubers by weight, 3-9 parts of liquorice roots by weight, 10-20 parts of platycodon roots by weight and 15-25 parts of dried rehmannia roots by weight; the auxiliary materials comprise at least one of starch and mogroside, and the weight ratio of the extracts to the auxiliary materials is (3-5):(8-12). The invention further provides a preparation method of the heat clearing granules. The curative effect of the throat heat clearing granules can be effectively improved, meanwhile, the taste is considered, and the throat heat clearing granules have other curative effects and have very high practical value as well as popularization and application value.
Description
Technical field
The present invention relates to a kind of Qingyan Granules and preparation method thereof.
Background technology
At present, stimulation due to air quality decline, maror and tobacco and wine, the sickness rate making laryngopharyngeal diseases substantially increases, become the big factor that harm people are healthy, this problem is especially apparent in special industries such as teacher, shop-assistant, performers, not only affect it healthy, also affect live and work simultaneously.
The treatment of laryngopharyngeal diseases, it is preferred that emphasis is enhancing body resistance, and the moistening and cleaning throat medicament categories realizing at present building up resistance is various, effect is passed different judgements on, but in general, curative effect is also inconspicuous, and effect is single, it is difficult to meet being actually needed of people.
Summary of the invention
It is an object of the invention to provide a kind of Qingyan Granules, the problem solving Qingyan Granules function singleness in prior art, curative effect deficiency.
To achieve these goals, the technical solution used in the present invention is as follows:
A kind of Qingyan Granules, is made up of the extract of following raw material and adjuvant, and described raw material is: Radix Scrophulariae 15～25 weight portion, Radix Ophiopogonis 15～25 weight portion, Radix Glycyrrhizae 3～9 weight portion, Radix Platycodonis 10～20 weight portion, Radix Rehmanniae 15～25 weight portion；Described adjuvant is at least the one in starch, mogroside, and the weight ratio of extract and adjuvant is 3～5:8～12.
Preferably, described extract is 4:10 with the weight ratio of adjuvant；Described raw material is: Radix Scrophulariae 20g, Radix Ophiopogonis 20g, Radix Glycyrrhizae 6g, Radix Platycodonis 15g, Radix Rehmanniae 20g.
Preferably, described adjuvant is soluble starch.
Preferably, described adjuvant is the mixture of starch and mogroside, and the proportion of three is 51.
Meanwhile, the preparation method that present invention also offers above-mentioned Qingyan Granules, comprise the following steps:
(1) putting in extraction pot by Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae, Radix Platycodonis, Radix Rehmanniae according to weight ratio, add the cold water of all raw material weight sums 10 times, heating decocts 2 hours, and separating and filtering obtains first time extracting solution and medicinal residues；
(2) adding the cold water of all raw material weight sums 8 times in medicinal residues, heating decocts 1.5 hours, and separating and filtering obtains second time extracting solution；
(3) first time extracting solution is merged with second time extracting solution, be evaporated to the extractum that proportion is 1.15；
(4) it is that 4:10 adds adjuvant, cold drying in extractum according to extractum and adjuvant proportion, prepares Qingyan Granules.
Preferably, in described extraction pot, the maximum temperature of heating is 100 DEG C.
Preferably, in described step (3), pressure during concentrated extracting solution is 0.4～0.8*105pa。
Preferably, in described step (4), baking temperature is 60 DEG C.
Compared with prior art, the method have the advantages that
(1) present invention by increasing Radix Rehmanniae on classical formula basis, its nourishing YIN to relieve dryness is utilized to promote the production of body fluid function, whole formula is made to be provided with positive effect in treatment hyperactivity of fire caused by deficiency of YIN, to the thirsty caused by hyperactivity of fire caused by deficiency of YIN, having a dizzy spell has good efficacy, make its function more diversified, the problem solving conventional formulation function singleness, curative effect deficiency.
(2) present invention is by the selection to adjuvant, substantially increases the mouthfeel of Qingyan Granules so that it is while having good efficacy, alleviates sense of discomfort when patient takes medicine and diabetes patient can also take.
(3) preparation method of Qingyan Granules has been improved by the present invention, by the control to the adjustment of component proportion, the control of boil medicine time and number of times and extract dry environment, each component property of medicine is made to obtain maximum performance, and then substantially increase the overall curative effect of Qingyan Granules, it is greatly improved the practical value of medicine.
(4) present invention is compared with the formula of existing Qingyan Granules, and under the premise not affected the treatment, component is greatly simplified, and cost is substantially reduced, and has prominent substantive distinguishing features and significant technological progress.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, and embodiments of the present invention include but not limited to the following example.
Qingyan Granules disclosed by the invention, based on Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae, Radix Platycodonis, is added Radix Rehmanniae and suitable adjuvant, is prepared by special preparation method.Compared with prior art, its cost performance is obviously improved, and is especially suitable for popularization and application.With example, formula and preparation method are described in detail below.
Embodiment 1
A kind of Qingyan Granules, is made up of the extract of following raw material and adjuvant, and described raw material is: Radix Scrophulariae 15g, Radix Ophiopogonis 15g, Radix Glycyrrhizae 3g, Radix Platycodonis 20g, Radix Rehmanniae 25g；Described adjuvant is mogroside, and the extract of raw material and the weight ratio of adjuvant are 3:8.
The preparation method of above-mentioned Qingyan Granules, comprises the following steps:
(1) by Radix Scrophulariae 15g, Radix Ophiopogonis 15g, Radix Glycyrrhizae 3g, Radix Platycodonis 20g, Radix Rehmanniae 25g put in extraction pot, add 780g cold water, at 100 DEG C, heating decocts 2 hours, and separating and filtering obtains first time extracting solution and medicinal residues；
(2) adding the cold water of 624g in medicinal residues, at 100 DEG C, heating decocts 1.5 hours, and separating and filtering obtains second time extracting solution；
(3) first time extracting solution is merged with second time extracting solution, be decompressed to 0.4*105Concentrate during pa, obtain the extractum that proportion is 1.15；
(4) it is that 3:8 adds mogroside in extractum according to extractum and adjuvant proportion, dry at 60 DEG C, prepare Qingyan Granules.
By the Qingyan Granules that said method prepares, not only moistening and cleaning throat effect is better, and the thirsty caused at treatment hyperactivity of fire caused by deficiency of YIN, have a dizzy spell in also there is good curative effect, mouthfeel is fabulous simultaneously.
Embodiment 2
A kind of Qingyan Granules, is made up of the extract of following raw material and adjuvant, and described raw material is: Radix Scrophulariae 25g, Radix Ophiopogonis 25g, Radix Glycyrrhizae 9g, Radix Platycodonis 10g, Radix Rehmanniae 15g；Described adjuvant is soluble starch, and the extract of raw material and the weight ratio of adjuvant are 5:12.
The preparation method of above-mentioned Qingyan Granules, comprises the following steps:
(1) by Radix Scrophulariae 25g, Radix Ophiopogonis 25g, Radix Glycyrrhizae 9g, Radix Platycodonis 10g, Radix Rehmanniae 15g put in extraction pot, add 840g cold water, at 100 DEG C, heating decocts 2 hours, and separating and filtering obtains first time extracting solution and medicinal residues；
(2) adding the cold water of 672g in medicinal residues, at 100 DEG C, heating decocts 1.5 hours, and separating and filtering obtains second time extracting solution；
(3) first time extracting solution is merged with second time extracting solution, be decompressed to 0.8*105Concentrate during pa, obtain the extractum that proportion is 1.15；
(4) it is that 5:12 adds soluble starch in extractum according to extractum and adjuvant proportion, dry at 60 DEG C, prepare Qingyan Granules.
By the present embodiment prepare Qingyan Granules, while moistening and cleaning throat so that it is for treatment hyperactivity of fire caused by deficiency of YIN cause thirsty, have a dizzy spell time also there is obvious curative effects.
Embodiment 3
A kind of Qingyan Granules, is made up of the extract of following raw material and adjuvant, and described raw material is: Radix Scrophulariae 20g, Radix Ophiopogonis 20g, Radix Glycyrrhizae 6g, Radix Platycodonis 15g, Radix Rehmanniae 20g；Described adjuvant is the mixture of soluble starch and mogroside, and the extract of raw material and the weight ratio of adjuvant are 4:10.
The preparation method of above-mentioned Qingyan Granules, comprises the following steps:
(1) by Radix Scrophulariae 20g, Radix Ophiopogonis 20g, Radix Glycyrrhizae 6g, Radix Platycodonis 15g, Radix Rehmanniae 20g put in extraction pot, add 810g cold water, at 100 DEG C, heating decocts 2 hours, and separating and filtering obtains first time extracting solution and medicinal residues；
(2) adding the cold water of 648g in medicinal residues, at 100 DEG C, heating decocts 1.5 hours, and separating and filtering obtains second time extracting solution；
(3) first time extracting solution is merged with second time extracting solution, be decompressed to 0.6*105Concentrate during pa, obtain the extractum that proportion is 1.15；
(4) be 4:10 to extractum adds the weight ratio of soluble starch and mogroside, soluble starch and mogroside according to extractum and adjuvant proportion it is 5:1, dry at 60 DEG C, prepare Qingyan Granules.
By the Qingyan Granules that the present embodiment prepares, moistening and cleaning throat curative effect is best, and the thirsty, the treatment curative effect of having a dizzy spell that cause for hyperactivity of fire caused by deficiency of YIN are also fairly obvious, and mouthfeel is fabulous, has significantly high market value and popularizing application prospect.
In the present invention, adjuvant is mainly used in changing the mouthfeel of Qingyan Granules, therefore, except adjuvant disclosed above, it is also possible to select the food materials that other mouthfeels are good as adjuvant, no longer the change of adjuvant is described in detail at this.
Above-described embodiment is only the preferred embodiments of the present invention, not limiting the scope of the invention, as long as adopting the design principle of the present invention, and the change carrying out non-creativeness work on this basis and making, all should belong within protection scope of the present invention.
Claims (8)
1. a Qingyan Granules, it is characterised in that be made up of the extract of following raw material and adjuvant, described raw material is: Radix Scrophulariae 15～25 weight portion, Radix Ophiopogonis 15～25 weight portion, Radix Glycyrrhizae 3～9 weight portion, Radix Platycodonis 10～20 weight portion, Radix Rehmanniae 15～25 weight portion；Described adjuvant is at least the one in starch, mogroside, and the weight ratio of extract and adjuvant is 3～5:8～12.
2. a kind of Qingyan Granules according to claim 1, it is characterised in that the weight ratio of described extract and adjuvant is 4:10；Described raw material is: Radix Scrophulariae 20g, Radix Ophiopogonis 20g, Radix Glycyrrhizae 6g, Radix Platycodonis 15g, Radix Rehmanniae 20g.
3. a kind of Qingyan Granules according to claim 2, it is characterised in that described adjuvant is soluble starch.
4. a kind of Qingyan Granules according to claim 2, it is characterised in that described adjuvant is the mixture of soluble starch and mogroside, and the proportion of three is 51.
5. the preparation method of a Qingyan Granules, it is characterised in that comprise the following steps:
(1) putting in extraction pot by Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae, Radix Platycodonis, Radix Rehmanniae according to weight ratio, add the cold water of all raw material weight sums 10 times, heating decocts 2 hours, and separating and filtering obtains first time extracting solution and medicinal residues；
(2) adding the cold water of all raw material weight sums 8 times in medicinal residues, heating decocts 1.5 hours, and separating and filtering obtains second time extracting solution；
(3) first time extracting solution is merged with second time extracting solution, be evaporated to the extractum that proportion is 1.15；
(4) it is that 4:10 adds adjuvant, cold drying in extractum according to extractum and adjuvant proportion, prepares Qingyan Granules.
6. the preparation method of a kind of Qingyan Granules according to claim 5, it is characterised in that in described extraction pot, the maximum temperature of heating is 100 DEG C.
7. the preparation method of a kind of Qingyan Granules according to claim 5, it is characterised in that in described step (3), pressure during concentrated extracting solution is 0.4～0.8*105pa。
8. the preparation method of a kind of Qingyan Granules according to claim 5, it is characterised in that in described step (4), baking temperature is 60 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610220751.3A CN105796867A (en) | 2016-04-11 | 2016-04-11 | Throat heat clearing granules and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610220751.3A CN105796867A (en) | 2016-04-11 | 2016-04-11 | Throat heat clearing granules and preparation method thereof |
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| CN105796867A true CN105796867A (en) | 2016-07-27 |
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| CN201610220751.3A Pending CN105796867A (en) | 2016-04-11 | 2016-04-11 | Throat heat clearing granules and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101469145A (en) * | 2007-12-28 | 2009-07-01 | 中国科学院兰州化学物理研究所 | Process for preparing attapulgite based composite material |
| CN103340406A (en) * | 2013-07-17 | 2013-10-09 | 浙江省磐安县外贸药业有限公司 | Preparation method of cordyceps sinensis granules |
-
2016
- 2016-04-11 CN CN201610220751.3A patent/CN105796867A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101469145A (en) * | 2007-12-28 | 2009-07-01 | 中国科学院兰州化学物理研究所 | Process for preparing attapulgite based composite material |
| CN103340406A (en) * | 2013-07-17 | 2013-10-09 | 浙江省磐安县外贸药业有限公司 | Preparation method of cordyceps sinensis granules |
Non-Patent Citations (2)
| Title |
|---|
| 成新艳等: ""增液汤加味治疗慢性咽炎97例"", 《陕西中医》 * |
| 朱胤龙: "《实用临床中药学》", 31 July 2013, 陕西科学技术出版社 * |
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Application publication date: 20160727 |