CN105796418A - Dandruff removal shampoo containing plant extract and preparation method of dandruff removal shampoo - Google Patents

Dandruff removal shampoo containing plant extract and preparation method of dandruff removal shampoo Download PDF

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Publication number
CN105796418A
CN105796418A CN201610168692.XA CN201610168692A CN105796418A CN 105796418 A CN105796418 A CN 105796418A CN 201610168692 A CN201610168692 A CN 201610168692A CN 105796418 A CN105796418 A CN 105796418A
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parts
microwave extraction
extraction thing
microwave
plant extract
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CN201610168692.XA
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Chinese (zh)
Inventor
李苏扬
李文遐
徐勤霞
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Suzhou Bec Biological Technology Co Ltd
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Suzhou Bec Biological Technology Co Ltd
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Priority to CN201610168692.XA priority Critical patent/CN105796418A/en
Publication of CN105796418A publication Critical patent/CN105796418A/en
Priority to PCT/CN2016/107209 priority patent/WO2017161908A1/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/006Antidandruff preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/008Preparations for oily hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/12Preparations containing hair conditioners

Abstract

The invention discloses dandruff removal shampoo containing plant extract and a preparation method of the dandruff removal shampoo. The dandruff removal shampoo is composed of kapok microwave extract, dry tea oil microwave extract, black sesame microwave extract, lauryl polyoxyethylene sodium sulfate, lauryl sodium sulfate, cocomut oil die thanolamide, ethylene glycol distearate, ethylene diamine tetraacetic acid, glycerinum, conditioner, essence, preservative and deionized water. The preparation method includes the steps that firstly the kapok microwave extract, the dry tea oil microwave extract and the black sesame microwave extract are prepared through a microwave extraction method, then all the components are sequentially added into a reaction pot and stirred and mixed to be uniform, finally pH is adjusted with citric acid, and the dandruff removal shampoo containing plant extract can be obtained. The dandruff removal shampoo can inhibit scalp bacteria and fungi, reduce the scalp falling off speed, relieve scalp pruritus, promote scalp blood circulation, remove scalp grease, improve absorption of hair follicle to nutritious ingredients and achieve the effects of removing dandruff, reliving itching and balancing scalp grease secretion.

Description

A kind of dandruff control shampoo containing containing plant extract and preparation method thereof
Technical field
The present invention relates to cosmetic technical field, be specifically related to a kind of dandruff control shampoo containing containing plant extract and preparation method thereof.
Background technology
With the quickening pace of modern life, the increasing of operating pressure, increasing artificial dandruff and worried, dandruff problem has become as the second largest hair healthy problem being only second to alopecia and perplex consumer.Reporting according to professional investigation, there is dandruff puzzlement problem in the people of nearly 67%, namely has the people of 2/3 to have dandruff problem, additionally, the interviewee of nearly 95% has a rebound phenomenon, and occurred Proportion of patients that dandruff recurs within 5 days up to 90%.
Prior art use chemistry anti-dandruff agent such as Zinc Pyrithione, climbazole etc. are used for removing the dandruff.In the process realizing the present invention, inventor have found that prior art at least there is problems in that dandruff control shampoo containing of the prior art has just begun to use comparison effective, time one, long decreased effectiveness was even without obvious effect, reason is that chemistry anti-dandruff agent only rests on the cleaning to scalp surface, can not thoroughly eradicate dandruff, make chemical composition remain on scalp on the contrary, scalp is caused and further stimulates and injury.Therefore, life-time service chemistry anti-dandruff agent, it does not have fundamentally solve to cause the scalp balance of finance, credits and materials problem that scalp pomade, pruritus, dandruff are many, also without a kind of dandruff control shampoo containing traditional Chinese medicines with the feature such as nontoxic, harmless, safe in prior art.
Summary of the invention
For above-mentioned the deficiencies in the prior art, the present invention provides a kind of dandruff control shampoo containing containing plant extract and preparation method thereof, and the shampoo prepared can be anti-dandruff, antipruritic and safe, non-stimulated.
The technical solution adopted in the present invention is as follows:
A kind of dandruff control shampoo containing containing plant extract, component including following weight portion: Flos Bombacis Malabarici microwave extraction thing 1~5 part, tea oil residule microwave extraction thing 1~5 part, Semen Sesami Nigrum microwave extraction thing 1~5 part, 20~40 parts of lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate 5~10 parts, cocos nucifera oil diglycollic amide 0.5~3 part, stearic acid diethylene glycol dilaurate 0.5~2.5 part, disodiumedetate 0.1~0.3 part, glycerol 3~15 parts, conditioner 5.5~10 parts, 0.05~0.25 part of essence, preservative 0.05~0.15 part, deionized water 20~45 parts.
Preferably, the described dandruff control shampoo containing containing plant extract, including the component of following weight portion: Flos Bombacis Malabarici microwave extraction thing 2 parts, tea oil residule microwave extraction thing 2 parts, Semen Sesami Nigrum microwave extraction thing 2 parts, 30 parts of lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate 8 parts, cocos nucifera oil diglycollic amide 2.5 parts, stearic acid diethylene glycol dilaurate 1.5 parts, disodiumedetate 0.2 part, glycerol 10 parts, conditioner 8 parts, 0.1 part of essence, preservative 0.1 part, deionized water 25 parts.
Preferably, described conditioner is emulsified silicone oil or amido silicon oil.
Preferably, described essence is cyclamen aldehyde or black nightshade aldehyde.
Preferably, described preservative is sodium benzoate.
The preparation method of the described dandruff control shampoo containing containing plant extract, comprises the following steps:
(1) prepared by Flos Bombacis Malabarici microwave extraction thing: weigh Flos Bombacis Malabarici, pulverizes, adds 8~12 times of water of Flos Bombacis Malabarici weight, carry out microwave extraction, then filter, obtain filtrate, and filtrate is concentrated into 0.5g/mL~1g/mL, obtains Flos Bombacis Malabarici microwave extraction thing;
(2) tea oil residule microwave extraction thing and Semen Sesami Nigrum microwave extraction thing are prepared respectively according to the method identical with Flos Bombacis Malabarici microwave extraction thing;
(3) by weight by lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate, cocos nucifera oil diglycollic amide, stearic acid diethylene glycol dilaurate, disodiumedetate, glycerol, conditioner, deionized water joins in reaction pot, is uniformly mixed, heating, to 80 DEG C~90 DEG C, stirs 30min~60min, when being then cooled to 40 DEG C~50 DEG C, add Flos Bombacis Malabarici microwave extraction thing, tea oil residule microwave extraction thing, Semen Sesami Nigrum microwave extraction thing, essence and preservative;
(4) with Fructus Citri Limoniae acid for adjusting pH to 5.5~6.5, the dandruff control shampoo containing containing plant extract is obtained.
Preferably, in described microwave loss mechanisms, microwave power is 100W~200W, and extraction time is 10min~30min.
The method have the benefit that this dandruff control shampoo containing containing plant extract can solve scalp from the daily nursing field of individual and have the problem such as dandruff, greasy, pruritus; some negative effects using chemistry anti-dandruff agent etc. to bring can be avoided, thus reaching the purpose of bactericidal, removing scurf and relieving itching, hair care and nourishing.Shampoo of the present invention has significantly functional, scalp is penetrated into by functional medicinal liquid, conditioning scalp environment, thus playing drug effect, scalp antibacterial and fungus can be suppressed, slow down scalp falling speed and scalp itch, promote scalp blood circulation, dispel scalp oils and fats, improve the hair follicle absorption to nutritional labeling.Clinical trial results shows, this dandruff control shampoo containing significantly reduces by the rear dandruff, anti-dandruff effective;Scalp itch is obviously improved, scalp greasy degree reduce, hair is submissive not short-tempered, it is easy to arrange, be a kind of integrate anti-dandruff, antipruritic, control oil, nourish dandruff control shampoo containing traditional Chinese medicines.
Detailed description of the invention
Below by specific embodiment, the present invention is further described in detail, but is not limited to this.
Embodiment 1
A kind of dandruff control shampoo containing containing plant extract, including the component of following weight portion: Flos Bombacis Malabarici microwave extraction thing 1 part, tea oil residule microwave extraction thing 1 part, Semen Sesami Nigrum microwave extraction thing 1 part, 20 parts of lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate 5 parts, cocos nucifera oil diglycollic amide 0.5 part, stearic acid diethylene glycol dilaurate 0.5 part, disodiumedetate 0.1 part, glycerol 3 parts, emulsified silicone oil 5.5 parts, cyclamen aldehyde 0.05 part, sodium benzoate 0.05 part, deionized water 20 parts.
The preparation method of the described dandruff control shampoo containing containing plant extract, comprises the following steps:
(1) prepared by Flos Bombacis Malabarici microwave extraction thing: weigh Flos Bombacis Malabarici, pulverizes, adds 8 times of water of Flos Bombacis Malabarici weight, carry out microwave extraction, and microwave power is 100W, and extraction time is 10min, then filters, and obtains filtrate, and filtrate is concentrated into 0.5g/mL, obtains Flos Bombacis Malabarici microwave extraction thing;
(2) tea oil residule microwave extraction thing and Semen Sesami Nigrum microwave extraction thing are prepared respectively according to the method identical with Flos Bombacis Malabarici microwave extraction thing;
(3) by weight by lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate, cocos nucifera oil diglycollic amide, stearic acid diethylene glycol dilaurate, disodiumedetate, glycerol, emulsified silicone oil, deionized water joins in reaction pot, is uniformly mixed, heating, to 80 DEG C, stirs 30min, when being then cooled to 40 DEG C, add Flos Bombacis Malabarici microwave extraction thing, tea oil residule microwave extraction thing, Semen Sesami Nigrum microwave extraction thing, cyclamen aldehyde and sodium benzoate;
(4) with Fructus Citri Limoniae acid for adjusting pH to 5.5, the dandruff control shampoo containing containing plant extract is obtained.
Embodiment 2
A kind of dandruff control shampoo containing containing plant extract, including the component of following weight portion: Flos Bombacis Malabarici microwave extraction thing 5 parts, tea oil residule microwave extraction thing 5 parts, Semen Sesami Nigrum microwave extraction thing 5 parts, 40 parts of lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate 10 parts, cocos nucifera oil diglycollic amide 3 parts, stearic acid diethylene glycol dilaurate 2.5 parts, disodiumedetate 0.3 part, glycerol 15 parts, emulsified silicone oil 10 parts, black nightshade aldehyde 0.25 part, sodium benzoate 0.15 part, deionized water 45 parts.
The preparation method of the described dandruff control shampoo containing containing plant extract, comprises the following steps:
(1) prepared by Flos Bombacis Malabarici microwave extraction thing: weigh Flos Bombacis Malabarici, pulverizes, adds 12 times of water of Flos Bombacis Malabarici weight, carry out microwave extraction, and microwave power is 200W, and extraction time is 30min, then filters, and obtains filtrate, and filtrate is concentrated into 1g/mL, obtains Flos Bombacis Malabarici microwave extraction thing;
(2) tea oil residule microwave extraction thing and Semen Sesami Nigrum microwave extraction thing are prepared respectively according to the method identical with Flos Bombacis Malabarici microwave extraction thing;
(3) by weight by lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate, cocos nucifera oil diglycollic amide, stearic acid diethylene glycol dilaurate, disodiumedetate, glycerol, emulsified silicone oil, deionized water joins in reaction pot, is uniformly mixed, heating, to 90 DEG C, stirs 60min, when being then cooled to 50 DEG C, add Flos Bombacis Malabarici microwave extraction thing, tea oil residule microwave extraction thing, Semen Sesami Nigrum microwave extraction thing, black nightshade aldehyde and sodium benzoate;
(4) with Fructus Citri Limoniae acid for adjusting pH to 6.0, the dandruff control shampoo containing containing plant extract is obtained.
Embodiment 3
A kind of dandruff control shampoo containing containing plant extract, including the component of following weight portion: Flos Bombacis Malabarici microwave extraction thing 4 parts, tea oil residule microwave extraction thing 3 parts, Semen Sesami Nigrum microwave extraction thing 2.5 parts, 35 parts of lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate 6 parts, cocos nucifera oil diglycollic amide 1.5 parts, stearic acid diethylene glycol dilaurate 2 parts, disodiumedetate 0.3 part, glycerol 8 parts, amido silicon oil 6 parts, cyclamen aldehyde 0.2 part, sodium benzoate 0.05 part, deionized water 40 parts.
The preparation method of the described dandruff control shampoo containing containing plant extract, comprises the following steps:
(1) prepared by Flos Bombacis Malabarici microwave extraction thing: weigh Flos Bombacis Malabarici, pulverizes, adds 12 times of water of Flos Bombacis Malabarici weight, carry out microwave extraction, microwave power is 180W, and extraction time is 25min, then filters, obtaining filtrate, filtrate is concentrated into 0.6g/mL, obtains Flos Bombacis Malabarici microwave extraction thing;
(2) tea oil residule microwave extraction thing and Semen Sesami Nigrum microwave extraction thing are prepared respectively according to the method identical with Flos Bombacis Malabarici microwave extraction thing;
(3) by weight by lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate, cocos nucifera oil diglycollic amide, stearic acid diethylene glycol dilaurate, disodiumedetate, glycerol, amido silicon oil, deionized water joins in reaction pot, is uniformly mixed, heating, to 80 DEG C, stirs 50min, when being then cooled to 40 DEG C, add Flos Bombacis Malabarici microwave extraction thing, tea oil residule microwave extraction thing, Semen Sesami Nigrum microwave extraction thing, cyclamen aldehyde and sodium benzoate;
(4) with Fructus Citri Limoniae acid for adjusting pH to 6.5, the dandruff control shampoo containing containing plant extract is obtained.
Embodiment 4
A kind of dandruff control shampoo containing containing plant extract, including the component of following weight portion: Flos Bombacis Malabarici microwave extraction thing 2 parts, tea oil residule microwave extraction thing 2 parts, Semen Sesami Nigrum microwave extraction thing 2 parts, 30 parts of lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate 8 parts, cocos nucifera oil diglycollic amide 2.5 parts, stearic acid diethylene glycol dilaurate 1.5 parts, disodiumedetate 0.2 part, glycerol 10 parts, amido silicon oil 8 parts, black nightshade aldehyde 0.1 part, sodium benzoate 0.1 part, deionized water 25 parts.
The preparation method of the described dandruff control shampoo containing containing plant extract, comprises the following steps:
(1) prepared by Flos Bombacis Malabarici microwave extraction thing: weigh Flos Bombacis Malabarici, pulverizes, adds 10 times of water of Flos Bombacis Malabarici weight, carry out microwave extraction, microwave power is 150W, and extraction time is 20min, then filters, obtaining filtrate, filtrate is concentrated into 0.7g/mL, obtains Flos Bombacis Malabarici microwave extraction thing;
(2) tea oil residule microwave extraction thing and Semen Sesami Nigrum microwave extraction thing are prepared respectively according to the method identical with Flos Bombacis Malabarici microwave extraction thing;
(3) by weight by lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate, cocos nucifera oil diglycollic amide, stearic acid diethylene glycol dilaurate, disodiumedetate, glycerol, amido silicon oil, deionized water joins in reaction pot, is uniformly mixed, heating, to 85 DEG C, stirs 45min, when being then cooled to 45 DEG C, add Flos Bombacis Malabarici microwave extraction thing, tea oil residule microwave extraction thing, Semen Sesami Nigrum microwave extraction thing, black nightshade aldehyde and sodium benzoate;
(4) with Fructus Citri Limoniae acid for adjusting pH to 6.0, the dandruff control shampoo containing containing plant extract is obtained.
The plant extract of the embodiment of the present invention can also add in more existing shampoos, and equally possible reaching controls oily, anti-dandruff, antipruritic effect.Embodiment described above, simply several more preferably detailed description of the invention of the present invention, the usual variations and alternatives that those skilled in the art carries out within the scope of technical solution of the present invention all should be included in protection scope of the present invention.

Claims (7)

1. the dandruff control shampoo containing containing plant extract, it is characterized in that including the component of following weight portion: Flos Bombacis Malabarici microwave extraction thing 1~5 part, tea oil residule microwave extraction thing 1~5 part, Semen Sesami Nigrum microwave extraction thing 1~5 part, 20~40 parts of lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate 5~10 parts, cocos nucifera oil diglycollic amide 0.5~3 part, stearic acid diethylene glycol dilaurate 0.5~2.5 part, disodiumedetate 0.1~0.3 part, glycerol 3~15 parts, conditioner 5.5~10 parts, 0.05~0.25 part of essence, preservative 0.05~0.15 part, deionized water 20~45 parts.
2. the dandruff control shampoo containing containing plant extract according to claim 1, it is characterized in that including the component of following weight portion: Flos Bombacis Malabarici microwave extraction thing 2 parts, tea oil residule microwave extraction thing 2 parts, Semen Sesami Nigrum microwave extraction thing 2 parts, 30 parts of lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate 8 parts, cocos nucifera oil diglycollic amide 2.5 parts, stearic acid diethylene glycol dilaurate 1.5 parts, disodiumedetate 0.2 part, glycerol 10 parts, conditioner 8 parts, 0.1 part of essence, preservative 0.1 part, deionized water 25 parts.
3. the dandruff control shampoo containing containing plant extract according to claim 1, it is characterised in that described conditioner is emulsified silicone oil or amido silicon oil.
4. the dandruff control shampoo containing containing plant extract according to claim 1, it is characterised in that described essence is cyclamen aldehyde or black nightshade aldehyde.
5. the dandruff control shampoo containing containing plant extract according to claim 1, it is characterised in that described preservative is sodium benzoate.
6. the preparation method of the dandruff control shampoo containing containing plant extract described in claim 1 to 5 any one, it is characterised in that comprise the steps:
(1) prepared by Flos Bombacis Malabarici microwave extraction thing: weigh Flos Bombacis Malabarici, pulverizes, adds 8~12 times of water of Flos Bombacis Malabarici weight, carry out microwave extraction, then filter, obtain filtrate, and filtrate is concentrated into 0.5g/mL~1g/mL, obtains Flos Bombacis Malabarici microwave extraction thing;
(2) tea oil residule microwave extraction thing and Semen Sesami Nigrum microwave extraction thing are prepared respectively according to the method identical with Flos Bombacis Malabarici microwave extraction thing;
(3) by weight by lauryl alcohol polyethylene glycol oxide sodium sulfate, sodium lauryl sulphate, cocos nucifera oil diglycollic amide, stearic acid diethylene glycol dilaurate, disodiumedetate, glycerol, conditioner, deionized water joins in reaction pot, is uniformly mixed, heating, to 80 DEG C~90 DEG C, stirs 30min~60min, when being then cooled to 40 DEG C~50 DEG C, add Flos Bombacis Malabarici microwave extraction thing, tea oil residule microwave extraction thing, Semen Sesami Nigrum microwave extraction thing, essence and preservative;
(4) with Fructus Citri Limoniae acid for adjusting pH to 5.5~6.5, the dandruff control shampoo containing containing plant extract is obtained.
7. the preparation method of the dandruff control shampoo containing containing plant extract according to claim 6, it is characterised in that in described microwave loss mechanisms, microwave power is 100W~200W, and extraction time is 10min~30min.
CN201610168692.XA 2016-03-23 2016-03-23 Dandruff removal shampoo containing plant extract and preparation method of dandruff removal shampoo Pending CN105796418A (en)

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PCT/CN2016/107209 WO2017161908A1 (en) 2016-03-23 2016-11-25 Anti-dandruff shampoo containing plant extracts and preparation method therefor

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CN111529479B (en) * 2020-06-08 2022-08-26 华中科技大学同济医学院附属协和医院 Shampoo with sterilization and disinfection functions and preparation method thereof
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CN115381748B (en) * 2022-09-21 2023-10-31 广州环亚化妆品科技股份有限公司 Oil-control itching-relieving composition and preparation method and application thereof
CN116327663B (en) * 2023-05-19 2023-08-01 昆明素颜素心生物科技有限公司 Plant extract compound for hair care cosmetics, and preparation method and application thereof

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Application publication date: 20160727