CN105792850A - 聚合物-碳水化合物的缀合物的药物转递技术 - Google Patents

聚合物-碳水化合物的缀合物的药物转递技术 Download PDF

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Publication number
CN105792850A
CN105792850A CN201480066482.9A CN201480066482A CN105792850A CN 105792850 A CN105792850 A CN 105792850A CN 201480066482 A CN201480066482 A CN 201480066482A CN 105792850 A CN105792850 A CN 105792850A
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Prior art keywords
acid
cholesterol
monomethoxypolyethylene glycol
carrier
amino
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Pending
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CN201480066482.9A
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English (en)
Chinese (zh)
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念·吴
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Individual
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Individual
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Priority to CN202110239811.7A priority Critical patent/CN113274506A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/22—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the initiator used in polymerisation
    • C08G2650/26—Sugars or saccharides used as initiators
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480066482.9A 2013-12-05 2014-12-05 聚合物-碳水化合物的缀合物的药物转递技术 Pending CN105792850A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110239811.7A CN113274506A (zh) 2013-12-05 2014-12-05 聚合物-碳水化合物的缀合物的药物转递技术

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361912228P 2013-12-05 2013-12-05
US61/912,228 2013-12-05
PCT/US2014/068798 WO2015085173A1 (en) 2013-12-05 2014-12-05 Polymer-carbohydrate conjugates for drug delivery technology

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202110239811.7A Division CN113274506A (zh) 2013-12-05 2014-12-05 聚合物-碳水化合物的缀合物的药物转递技术

Publications (1)

Publication Number Publication Date
CN105792850A true CN105792850A (zh) 2016-07-20

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Family Applications (2)

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CN201480066482.9A Pending CN105792850A (zh) 2013-12-05 2014-12-05 聚合物-碳水化合物的缀合物的药物转递技术
CN202110239811.7A Pending CN113274506A (zh) 2013-12-05 2014-12-05 聚合物-碳水化合物的缀合物的药物转递技术

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Country Link
US (1) US10835608B2 (enExample)
EP (1) EP3077006B1 (enExample)
JP (1) JP6646578B2 (enExample)
CN (2) CN105792850A (enExample)
CA (1) CA2932123C (enExample)
WO (1) WO2015085173A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108026131A (zh) * 2015-06-23 2018-05-11 吴念 聚合物-环糊精-脂质的缀合物
WO2018133766A1 (zh) * 2017-01-17 2018-07-26 亚飞（上海）生物医药科技有限公司 分子定点靶向和激活的激酶抑制剂的制备和用途
CN111053741A (zh) * 2019-12-31 2020-04-24 江苏省中医院 一种用于治疗炎症性肠病的基于β-谷甾醇与5-ASA的口服多敏感胶束前药

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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EP2968239B1 (en) 2013-03-14 2019-04-24 The University of Massachusetts Methods of inhibiting cataracts and presbyopia
WO2016209732A1 (en) 2015-06-23 2016-12-29 Wu Nian Polymer-cyclodextrin-lipid conjugates
AU2016303661B2 (en) * 2015-07-31 2020-12-10 Arcturus Therapeutics, Inc. Multiligand agent for drug delivery
EP3373921B1 (en) 2015-11-13 2019-08-28 The University of Massachusetts Bifunctional molecules containing peg for use in inhibiting cataracts and presbyopia
CN106957421B (zh) * 2017-03-31 2018-11-20 河南大学 一种茄尼醇衍生物、制备方法及其应用
EP3661563A4 (en) * 2017-07-31 2021-11-10 The Ohio State Innovation Foundation BIOMIMETIC NANOMATERIALS AND THEIR USES
WO2019143971A2 (en) * 2018-01-18 2019-07-25 Sienna Biopharmaceuticals, Inc. Formulations for dermal delivery of polymer conjugates of indolocarbazole compounds with reduced exposure
AU2019377525B2 (en) * 2018-11-09 2025-10-16 Translate Bio, Inc. Multi-PEG lipid compounds
AU2020303447A1 (en) * 2019-06-26 2022-01-27 Biorchestra Co., Ltd. Micellar nanoparticles and uses thereof
WO2025029758A1 (en) * 2023-07-28 2025-02-06 Wu Nian Polyethylene glycol-saccharide-lipid conjugates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120202979A1 (en) * 2011-02-08 2012-08-09 Nian Wu Polymer-carbohydrate-lipid conjugates
CN102665685A (zh) * 2009-06-02 2012-09-12 念·吴 纯的peg-脂质缀合物

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US6309633B1 (en) * 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US7833992B2 (en) * 2001-05-18 2010-11-16 Merck Sharpe & Dohme Conjugates and compositions for cellular delivery
CN1911450A (zh) * 2006-08-21 2007-02-14 沈阳药科大学 一种含d－半乳糖和甾醇或脂肪醇的肝靶向辅料及其制剂
CN101831067A (zh) * 2010-05-31 2010-09-15 王二新 聚乙二醇脂类缀合物及其在制备药物中的应用
US20120232169A1 (en) * 2011-03-07 2012-09-13 Biozone Pharmaceuticals, Inc. Highly monodisperse branched peg-lipid conjugates
US8883177B2 (en) * 2011-06-28 2014-11-11 Nian Wu Pharmaceutical compositions for parenteral administration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102665685A (zh) * 2009-06-02 2012-09-12 念·吴 纯的peg-脂质缀合物
US20120202979A1 (en) * 2011-02-08 2012-08-09 Nian Wu Polymer-carbohydrate-lipid conjugates

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108026131A (zh) * 2015-06-23 2018-05-11 吴念 聚合物-环糊精-脂质的缀合物
CN108026131B (zh) * 2015-06-23 2021-12-10 吴念 聚合物-环糊精-脂质的缀合物
WO2018133766A1 (zh) * 2017-01-17 2018-07-26 亚飞（上海）生物医药科技有限公司 分子定点靶向和激活的激酶抑制剂的制备和用途
US11078232B2 (en) 2017-01-17 2021-08-03 Yafei Shanghai Biology Medicine Science & Technology Co. Ltd. Preparation and use of molecular site targeted and activated kinase inhibitor
CN111053741A (zh) * 2019-12-31 2020-04-24 江苏省中医院 一种用于治疗炎症性肠病的基于β-谷甾醇与5-ASA的口服多敏感胶束前药
CN111053741B (zh) * 2019-12-31 2021-09-28 江苏省中医院 一种用于治疗炎症性肠病的基于β-谷甾醇与5-ASA的口服多敏感胶束前药

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Publication number Publication date
WO2015085173A1 (en) 2015-06-11
EP3077006A1 (en) 2016-10-12
EP3077006A4 (en) 2017-08-30
US10835608B2 (en) 2020-11-17
CA2932123C (en) 2022-05-31
EP3077006B1 (en) 2020-08-19
JP2016539165A (ja) 2016-12-15
CA2932123A1 (en) 2015-06-11
CN113274506A (zh) 2021-08-20
US20150157721A1 (en) 2015-06-11
JP6646578B2 (ja) 2020-02-14

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Application publication date: 20160720