CN105777710B - 一种艾乐替尼的合成方法 - Google Patents
一种艾乐替尼的合成方法 Download PDFInfo
- Publication number
- CN105777710B CN105777710B CN201610206224.7A CN201610206224A CN105777710B CN 105777710 B CN105777710 B CN 105777710B CN 201610206224 A CN201610206224 A CN 201610206224A CN 105777710 B CN105777710 B CN 105777710B
- Authority
- CN
- China
- Prior art keywords
- dimethyl
- dihydro
- naphthalenones
- reaction
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610206224.7A CN105777710B (zh) | 2016-04-05 | 2016-04-05 | 一种艾乐替尼的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610206224.7A CN105777710B (zh) | 2016-04-05 | 2016-04-05 | 一种艾乐替尼的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105777710A CN105777710A (zh) | 2016-07-20 |
CN105777710B true CN105777710B (zh) | 2018-09-04 |
Family
ID=56395640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610206224.7A Active CN105777710B (zh) | 2016-04-05 | 2016-04-05 | 一种艾乐替尼的合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105777710B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107129488A (zh) * | 2017-04-21 | 2017-09-05 | 湖南博奥德生物医药技术开发有限公司 | 一种艾乐替尼的制备方法 |
CN106905226A (zh) * | 2017-04-21 | 2017-06-30 | 湖南博奥德生物医药技术开发有限公司 | 一种艾乐替尼中间体的制备方法 |
CN107011245A (zh) * | 2017-04-21 | 2017-08-04 | 湖南博奥德生物医药技术开发有限公司 | 一种艾乐替尼中间体的制备方法 |
CN106892861A (zh) * | 2017-04-21 | 2017-06-27 | 湖南博奥德生物医药技术开发有限公司 | 一种艾乐替尼中间体的制备方法 |
US11098037B2 (en) | 2017-07-05 | 2021-08-24 | Fresenius Kabi Oncology Ltd. | Process for preparing alectinib or a pharmaceutically acceptable salt thereof |
EP3556754A1 (en) | 2018-12-07 | 2019-10-23 | Fresenius Kabi iPSUM S.r.l. | Process for the preparation of alectinib |
CN110790652A (zh) * | 2019-11-15 | 2020-02-14 | 南京红杉生物科技有限公司 | 一种艾乐替尼中间体及其合成方法、中间物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG175707A1 (en) * | 2009-06-10 | 2011-12-29 | Chugai Pharmaceutical Co Ltd | Tetracyclic compound |
NZ608312A (en) * | 2010-08-20 | 2015-02-27 | Chugai Pharmaceutical Co Ltd | Composition containing tetracyclic compound |
JP5006987B2 (ja) * | 2010-11-22 | 2012-08-22 | 中外製薬株式会社 | 4環性化合物を含む医薬 |
CA2895846A1 (en) * | 2012-12-20 | 2014-06-26 | Concert Pharmaceuticals, Inc. | Deuterated alk inhibitors |
-
2016
- 2016-04-05 CN CN201610206224.7A patent/CN105777710B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN105777710A (zh) | 2016-07-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105777710B (zh) | 一种艾乐替尼的合成方法 | |
CN108047261A (zh) | 一种克立硼罗的制备方法 | |
CN106928184B (zh) | 一种艾乐替尼的制备方法 | |
CN112110899B (zh) | 一种吡咯替尼的合成方法 | |
CN107176955A (zh) | 一种巴瑞替尼的制备方法 | |
CN107129488A (zh) | 一种艾乐替尼的制备方法 | |
CN102584795A (zh) | 一种克里唑替尼的制备方法 | |
CN107033124B (zh) | 一种艾乐替尼的制备方法 | |
CN103570633B (zh) | 吉非替尼的制备方法 | |
CN114044777B (zh) | 一种磷酸芦可替尼的制备方法 | |
CN106632244A (zh) | 一种制备抗癌药物Niraparib的新型合成方法 | |
CN107033125B (zh) | 一种艾乐替尼的制备方法 | |
CN101462974A (zh) | 5-氨基酮戊酸盐酸盐的合成方法 | |
CN109867673B (zh) | 一种合成帕布昔利布的方法 | |
CN106892860B (zh) | 一种艾乐替尼中间体的制备方法 | |
CN112279838B (zh) | 一种吡咯替尼的制备方法 | |
CN106518842A (zh) | 一种艾乐替尼的制备方法 | |
CN105418681A (zh) | 一种磷酸特地唑胺的制备方法 | |
CN107118215B (zh) | 一种治疗乳腺癌药物瑞博西尼中间体的制备方法 | |
CN107417603B (zh) | 一种克里唑替尼中间体制备方法 | |
CN107011245A (zh) | 一种艾乐替尼中间体的制备方法 | |
CN106928125A (zh) | 一种艾乐替尼中间体的制备方法 | |
CN109867695B (zh) | 一种匹伐他汀钙中间体的新制备方法 | |
CN107903209B (zh) | 一种2-氨基-5-氟吡啶-3-甲酸甲酯的合成方法 | |
CN106905226A (zh) | 一种艾乐替尼中间体的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information | ||
CB02 | Change of applicant information |
Address after: 410329 No. 908 Kang Wan Road, Liuyang economic and Technological Development Zone, Changsha, Hunan Applicant after: Hunan Eurasia Pharmaceutical Co., Ltd. Address before: 410329 No. 908 Kang Wan Road, Liuyang Changsha National Bio Pharmaceutical Industrial Park, Changsha, Hunan Applicant before: Hunan Ouya Biological Co., Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A synthetic method of erlotinib Effective date of registration: 20210430 Granted publication date: 20180904 Pledgee: Bank of Changsha Limited by Share Ltd. Liuyang branch Pledgor: Hunan Eurasia pharmaceutcal Corp.,Ltd. Registration number: Y2021430000009 |