CN105770816A - Stomach nourishing composition for regulating spleen and stomach - Google Patents
Stomach nourishing composition for regulating spleen and stomach Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention relates to a stomach nourishing composition for regulating the spleen and the stomach. The stomach nourishing composition is prepared from, by weight, 20-43 parts of herba rhodiolae extract, 50-68 parts of herba dendrobii extract, 20-35 parts of fresh ginger extract and 10-15 parts of honey. The stomach nourishing composition can strengthen the spleen, relieve dyspepsia and harmonize the stomach and has the obvious improvement effect on spleen-stomach deficiency type gastritis, and in the composition, the herba rhodiolae extract, the herba dendrobii extract and the fresh ginger extract have the synergistic effect on treatment of the spleen-stomach deficiency type gastritis.
Description
Technical field
The present invention relates to technical field of health care food, be specifically related to the nourishing the stomach compositions of a kind of function of spleen and stomach regulating.
Background technology
Chronic gastritis is one of modal disease in digestive system, clinically common superficial gastritis and atrophic gastritis two types.This disease medical history is longer, easy recurrent exerbation, it is difficult to radical cure, is a kind of disease of harm population health.The etiology and pathogenesis of chronic gastritis is always hindered by diet, overstrain, feelings will, and liver stomach, spleen are got along well, dysfunction of the spleen in transportation, stagnation of phlegm-damp in middle-JIAO, and strongly fragrant and heat-transformation, stasis of blood indigestion network ultimately result in the generation of chronic gastritis.
Chronic gastritis syndromic types is substantially summarized as by the traditional Chinese medical science five different TCM syndrome types, for type of deficiency of stomach yin, due to weakness of spleen and stomach, liver-stomach disharmony type, stomach network blood stasis type, spleen and stomach damp-heat type.It is uncomfortable that due to weakness of spleen and stomach shows as gastral cavilty portion dull pain clinically, happiness temperature pain relieved by pressing, nausea and vomiting, acid regurgitation and epigastric upset etc..In prior art, it has been found that Rhizoma Zingiberis Recens contains zingiberol, fragrance wet goods oiliness volatile matter and gingerol, mineral to be held, it is possible to facilitating digestion, stomach invigorating effect, can be used for treating gastritis.But not yet it have been found that Rhizoma Zingiberis Recens has effect of Synergistic treatment due to weakness of spleen and stomach gastritis with other food materials or Chinese herbal medicine.
Summary of the invention
It is an object of the invention to overcome the defect of above-mentioned prior art, the nourishing the stomach compositions of a kind of function of spleen and stomach regulating is provided, said composition is Rhizoma Zingiberis Recens, Herba Dendrobii, the extract of Radix Rhodiolae three and Mel mixing, it is possible to is obviously improved due to weakness of spleen and stomach gastritis, can be made into the health product of function of spleen and stomach regulating.
For achieving the above object, the present invention adopts the following technical scheme that
The nourishing the stomach compositions of a kind of function of spleen and stomach regulating, it is made up of the raw material of following parts by weight: Radix Rhodiolae extract part 20～43, Herba Dendrobii extract 50～68 parts, Rhizoma Zingiberis Recens extract 20～35 parts, Mel 10～15 parts.
Further, the Radix Rhodiolae extract of the present invention adopts following methods to prepare: takes Radix Rhodiolae medical material and is first crushed to 10～20 orders, it is subsequently adding 5～10 times of water soaking 10～20min that weight is Radix Rhodiolae medical material weight, big fire is the little fire micro-2～4h that boils of maintenance after boiling, ultrafiltration Aqueous extracts removes macromolecular substances again, and it is 1.2～1.3 that the aqueous extract after ultrafiltration is concentrated into relative density.
Further, described Herba Dendrobii extract prepares in accordance with the following methods: dendrobe powder is broken to 20～50 orders, it is placed in supercritical carbon dioxide extraction equipment, supercritical carbon dioxide extraction is carried out for organic solvent with ethanol, extracting pressure is 25～30MPa, extraction temperature is 40～45 DEG C, and extraction time is 4～6h.
Further, described Rhizoma Zingiberis Recens extract prepares in accordance with the following methods: pulverized by Rhizoma Zingiberis Recens, is placed in supercritical carbon dioxide extraction equipment and extracts, and extracting pressure is 20～25MPa, and extraction temperature is 35～45 DEG C, and extraction time is 2～3h.
Further, the compositions of the present invention is mixed through ultrasound wave by Radix Rhodiolae extract, Herba Dendrobii extract, Rhizoma Zingiberis Recens extract, Mel.
Compared with prior art, the invention has the beneficial effects as follows:
The nourishing the stomach compositions of the present invention can disappear stagnant stomach function regulating in spleen invigorating, and improve significantly effect to due to weakness of spleen and stomach gastritis tool, starts to take effect after taking one week, and after one month, effective percentage reaches more than 98%.
In the compositions of the present invention, the treatment of due to weakness of spleen and stomach gastritis is had the effect of Synergistic by Radix Rhodiolae extract, Herba Dendrobii extract, Rhizoma Zingiberis Recens extract three.
The compositions of the present invention, through clinical verification, has no side effect.
Detailed description of the invention
Below, the present invention is described further by being embodied as example.
Embodiment 1
The nourishing the stomach compositions of a kind of function of spleen and stomach regulating, it is made up of the raw material of following parts by weight: Radix Rhodiolae extract 30 parts, Herba Dendrobii extract 50 parts, Rhizoma Zingiberis Recens extract 20 parts, Mel 10 parts.
The nourishing the stomach compositions of above-mentioned function of spleen and stomach regulating is prepared by following methods:
(1) prepare Radix Rhodiolae extract: take Radix Rhodiolae medical material and be first crushed to 10～20 orders, be subsequently adding 5～10 times of water soaking 10～20min that weight is Radix Rhodiolae medical material weight.Big fire is the little fire micro-2～4h that boils of maintenance after boiling.Ultrafiltration Aqueous extracts again, ultrafiltration uses the film of molecular cut off 5000 to carry out ultrafiltration, and pressure is 0.1MPa.It is 1.2～1.3 that aqueous extract after ultrafiltration is concentrated into relative density.
(2) Herba Dendrobii extract is prepared: dendrobe powder is broken to 20～50 orders, it is placed in supercritical carbon dioxide extraction equipment, supercritical carbon dioxide extraction is carried out for organic solvent with ethanol, extracting pressure is 25～30MPa, extraction temperature is 40～45 DEG C, carbon dioxide volume flow is 50g/min, and the alcoholic solution and the carbon dioxide that pump into mass fraction to be simultaneously volume fraction be 60% extract 4～6h jointly.
(3) preparing Rhizoma Zingiberis Recens extract: pulverized by Rhizoma Zingiberis Recens, be placed in supercritical carbon dioxide extraction equipment and extract, extracting pressure is 20～25MPa, and extraction temperature is 35～45 DEG C, and extraction time is 2～3h.
(4) ultrasound wave mixing: by weight, take Radix Rhodiolae extract produced above 30 parts, Herba Dendrobii extract 50 parts, Rhizoma Zingiberis Recens extract 20 parts and add 10 parts of mix homogeneously in ultrasonic mixer of Mel, making the nourishing the stomach compositions of extractum shape.
Embodiment 2
The nourishing the stomach compositions of a kind of function of spleen and stomach regulating, it is made up of the raw material of following parts by weight: Radix Rhodiolae extract 20 parts, Herba Dendrobii extract 68 parts, Rhizoma Zingiberis Recens extract 25 parts, Mel 12 parts.
The nourishing the stomach compositions of above-mentioned function of spleen and stomach regulating is prepared by following methods:
(1) prepare Radix Rhodiolae extract: take Radix Rhodiolae medical material and be first crushed to 10～20 orders, be subsequently adding 5～10 times of water soaking 10～20min that weight is Radix Rhodiolae medical material weight.Big fire is the little fire micro-2～4h that boils of maintenance after boiling, then ultrafiltration Aqueous extracts, and ultrafiltration uses the film of molecular cut off 5000 to carry out ultrafiltration, and pressure is 0.1MPa.It is 1.2～1.3 that aqueous extract after ultrafiltration is concentrated into relative density.
(2) Herba Dendrobii extract is prepared: dendrobe powder is broken to 20～50 orders, it is placed in supercritical carbon dioxide extraction equipment, supercritical carbon dioxide extraction is carried out for organic solvent with ethanol, extracting pressure is 25～30MPa, extraction temperature is 40～45 DEG C, carbon dioxide volume flow is 50g/min, and the alcoholic solution and the carbon dioxide that pump into mass fraction to be simultaneously volume fraction be 60% extract 4～6h jointly.
(3) preparing Rhizoma Zingiberis Recens extract: pulverized by Rhizoma Zingiberis Recens, be placed in supercritical carbon dioxide extraction equipment and extract, extracting pressure is 20～25MPa, and extraction temperature is 35～45 DEG C, and extraction time is 2～3h.
(4) ultrasound wave mixing: by weight, take Radix Rhodiolae extract produced above 20 parts, Herba Dendrobii extract 68 parts, Rhizoma Zingiberis Recens extract 25 parts and add 12 parts of mix homogeneously in ultrasonic mixer of Mel, making the nourishing the stomach compositions of extractum shape.
Embodiment 3
The nourishing the stomach compositions of a kind of function of spleen and stomach regulating, it is made up of the raw material of following parts by weight: Radix Rhodiolae extract 43 parts, Herba Dendrobii extract 60 parts, Rhizoma Zingiberis Recens extract 35 parts, Mel 15 parts.
The nourishing the stomach compositions of above-mentioned function of spleen and stomach regulating is prepared by following methods:
(1) prepare Radix Rhodiolae extract: take Radix Rhodiolae medical material and be first crushed to 10～20 orders, be subsequently adding 5～10 times of water soaking 10～20min that weight is Radix Rhodiolae medical material weight.Big fire is the little fire micro-2～4h that boils of maintenance after boiling.Ultrafiltration Aqueous extracts again, ultrafiltration uses the film of molecular cut off 5000 to carry out ultrafiltration, and pressure is 0.1MPa.It is 1.2～1.3 that aqueous extract after ultrafiltration is concentrated into relative density.
(2) Herba Dendrobii extract is prepared: dendrobe powder is broken to 20～50 orders, it is placed in supercritical carbon dioxide extraction equipment, supercritical carbon dioxide extraction is carried out for organic solvent with ethanol, extracting pressure is 25～30MPa, extraction temperature is 40～45 DEG C, carbon dioxide volume flow is 50g/min, and the alcoholic solution and the carbon dioxide that pump into mass fraction to be simultaneously volume fraction be 60% extract 4～6h jointly.
(3) preparing Rhizoma Zingiberis Recens extract: pulverized by Rhizoma Zingiberis Recens, be placed in supercritical carbon dioxide extraction equipment and extract, extracting pressure is 20～25MPa, and extraction temperature is 35～45 DEG C, and extraction time is 2～3h.
(4) ultrasound wave mixing: by weight, take Radix Rhodiolae extract produced above 43 parts, Herba Dendrobii extract 60 parts, Rhizoma Zingiberis Recens extract 35 parts and add 15 parts of mix homogeneously in ultrasonic mixer of Mel, making the nourishing the stomach compositions of extractum shape.
Row 1 are implemented in contrast
(1) take Radix Rhodiolae medical material and be first crushed to 10～20 orders, be subsequently adding 5～10 times of water soaking 10～20min that weight is Radix Rhodiolae medical material weight.Big fire is the little fire micro-2～4h that boils of maintenance after boiling.Ultrafiltration Aqueous extracts again, ultrafiltration uses the film of molecular cut off 5000 to carry out ultrafiltration, and pressure is 0.1MPa.It is 1.2～1.3 that aqueous extract after ultrafiltration is concentrated into relative density.
(2) Herba Dendrobii extract is prepared: dendrobe powder is broken to 20～50 orders, it is placed in supercritical carbon dioxide extraction equipment, supercritical carbon dioxide extraction is carried out for organic solvent with ethanol, extracting pressure is 25～30MPa, extraction temperature is 40～45 DEG C, carbon dioxide volume flow is 50g/min, and the alcoholic solution and the carbon dioxide that pump into mass fraction to be simultaneously volume fraction be 60% extract 4～6h jointly.
(3) ultrasound wave mixing: by weight, take Radix Rhodiolae extract produced above 30 parts, Herba Dendrobii extract 50 parts and add 10 parts of mix homogeneously in ultrasonic mixer of Mel, making the nourishing the stomach compositions of extractum shape.
Comparative example 2
(1) prepare Radix Rhodiolae extract: take Radix Rhodiolae medical material and be first crushed to 10～20 orders, be subsequently adding 5～10 times of water soaking 10～20min that weight is Radix Rhodiolae medical material weight.Big fire is the little fire micro-2～4h that boils of maintenance after boiling.Ultrafiltration Aqueous extracts again, ultrafiltration uses the film of molecular cut off 5000 to carry out ultrafiltration, and pressure is 0.1MPa.It is 1.2～1.3 that aqueous extract after ultrafiltration is concentrated into relative density.
(2) preparing Rhizoma Zingiberis Recens extract: pulverized by Rhizoma Zingiberis Recens, be placed in supercritical carbon dioxide extraction equipment and extract, extracting pressure is 20～25MPa, and extraction temperature is 35～45 DEG C, and extraction time is 2～3h.
(3) ultrasound wave mixing: by weight, take Radix Rhodiolae extract produced above 30 parts, Rhizoma Zingiberis Recens extract 20 parts and add 10 parts of mix homogeneously in ultrasonic mixer of Mel, making the nourishing the stomach compositions of extractum shape.
Comparative example 3
(1) Herba Dendrobii extract is prepared: dendrobe powder is broken to 20～50 orders, it is placed in supercritical carbon dioxide extraction equipment, supercritical carbon dioxide extraction is carried out for organic solvent with ethanol, extracting pressure is 25～30MPa, extraction temperature is 40～45 DEG C, carbon dioxide volume flow is 50g/min, and the alcoholic solution and the carbon dioxide that pump into mass fraction to be simultaneously volume fraction be 60% extract 4～6h jointly.
(2) preparing Rhizoma Zingiberis Recens extract: pulverized by Rhizoma Zingiberis Recens, be placed in supercritical carbon dioxide extraction equipment and extract, extracting pressure is 20～25MPa, and extraction temperature is 35～45 DEG C, and extraction time is 2～3h.
(3) ultrasound wave mixing: by weight, take Herba Dendrobii extract produced above 50 parts, Rhizoma Zingiberis Recens extract 20 parts and add 10 parts of mix homogeneously in ultrasonic mixer of Mel, making the nourishing the stomach compositions of extractum shape.
Clinical effectiveness compares:
Choose 400 due to weakness of spleen and stomach gastritis sufferers and carry out clinical experiment, be divided into 4 groups.The nourishing the stomach compositions of the 1st group of patient's one after each meal every day 10ml embodiment 1, every day three times；The nourishing the stomach compositions of the 2nd group of patient one after each meal every day 10ml comparative example 1, every day three times；The nourishing the stomach compositions of the 3rd group of patient one after each meal every day 10ml comparative example 2, every day three times；The nourishing the stomach compositions of the 4th group of patient one after each meal every day 10ml comparative example 3, every day three times.After one month, each group patient takes the situation such as following table of effect:
Data above shows, improvement excellent to gastritis when Radix Rhodiolae extract, Herba Dendrobii extract, Rhizoma Zingiberis Recens extract three and Mel coordinate, be far longer than wherein any two with Mel in conjunction with time result of use.
For a person skilled in the art, can technical scheme as described above and design, make other various corresponding changes and deformation, and all these change and deformation all should belong within the protection domain of the claims in the present invention.
Claims (5)
1. the nourishing the stomach compositions of a function of spleen and stomach regulating, it is characterised in that be made up of the raw material of following parts by weight: Radix Rhodiolae extract part 20～43 parts, Herba Dendrobii extract 50～68 parts, Rhizoma Zingiberis Recens extract 20～35 parts, Mel 10～15 parts.
2. the nourishing the stomach compositions of function of spleen and stomach regulating as claimed in claim 1, it is characterized in that, described Radix Rhodiolae extract prepares in accordance with the following methods: takes Radix Rhodiolae medical material and is first crushed to 10～20 orders, it is subsequently adding 5～10 times of water soaking 10～20min that weight is Radix Rhodiolae medical material weight, big fire is the little fire micro-2～4h that boils of maintenance after boiling, ultrafiltration Aqueous extracts removes macromolecular substances again, and it is 1.2～1.3 that the aqueous extract after ultrafiltration is concentrated into relative density.
3. the nourishing the stomach compositions of function of spleen and stomach regulating as claimed in claim 1, it is characterized in that, described Herba Dendrobii extract prepares in accordance with the following methods: dendrobe powder is broken to 20～50 orders, it is placed in supercritical carbon dioxide extraction equipment, supercritical carbon dioxide extraction is carried out for organic solvent with ethanol, extracting pressure is 25～30MPa, and extraction temperature is 40～45 DEG C, and extraction time is 4～6h.
4. the nourishing the stomach compositions of function of spleen and stomach regulating as claimed in claim 1, it is characterized in that, described Rhizoma Zingiberis Recens extract prepares in accordance with the following methods: pulverized by Rhizoma Zingiberis Recens, it is placed in supercritical carbon dioxide extraction equipment and extracts, extracting pressure is 20～25MPa, extraction temperature is 35～45 DEG C, and extraction time is 2～3h.
5. the nourishing the stomach compositions of function of spleen and stomach regulating as claimed in claim 1, it is characterised in that: said composition is mixed through ultrasound wave by Radix Rhodiolae extract, Herba Dendrobii extract, Rhizoma Zingiberis Recens extract, Mel.
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Cited By (5)
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| CN106509885A (en) * | 2016-10-11 | 2017-03-22 | 广东罗特制药有限公司 | dendrobium officinale-panax notoginseng-rhodiola rosea l oral liquid and preparation method thereof |
| CN107753919A (en) * | 2017-12-08 | 2018-03-06 | 福州博中技术开发有限公司 | A kind of Chinese herbal medicament oral liquid for treating children cold-evil stomachache and preparation method thereof |
| CN109700989A (en) * | 2019-01-29 | 2019-05-03 | 广东逸丰生态实业有限公司 | A kind of honey refining dendrobium nobile nourishing the stomach paste and preparation method thereof |
| CN110384238A (en) * | 2019-08-19 | 2019-10-29 | 河南城建学院 | A kind of HERBA DENDROBII health care product and HERBA DENDROBII health care product electuary preparation method |
| CN112076251A (en) * | 2019-06-13 | 2020-12-15 | 陈奕帆 | Health tea for treating stomach diseases |
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| CN106509885B (en) * | 2016-10-11 | 2020-03-17 | 广东罗特制药有限公司 | Dendrobium officinale, pseudo-ginseng and rhodiola rosea oral liquid and preparation method thereof |
| CN107753919A (en) * | 2017-12-08 | 2018-03-06 | 福州博中技术开发有限公司 | A kind of Chinese herbal medicament oral liquid for treating children cold-evil stomachache and preparation method thereof |
| CN109700989A (en) * | 2019-01-29 | 2019-05-03 | 广东逸丰生态实业有限公司 | A kind of honey refining dendrobium nobile nourishing the stomach paste and preparation method thereof |
| CN112076251A (en) * | 2019-06-13 | 2020-12-15 | 陈奕帆 | Health tea for treating stomach diseases |
| CN110384238A (en) * | 2019-08-19 | 2019-10-29 | 河南城建学院 | A kind of HERBA DENDROBII health care product and HERBA DENDROBII health care product electuary preparation method |
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Application publication date: 20160720 |