CN105770808A - Preparation and quality control methods for borneol-musk bone-setting ointment pasters - Google Patents

Preparation and quality control methods for borneol-musk bone-setting ointment pasters Download PDF

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CN105770808A
CN105770808A CN201610172791.5A CN201610172791A CN105770808A CN 105770808 A CN105770808 A CN 105770808A CN 201610172791 A CN201610172791 A CN 201610172791A CN 105770808 A CN105770808 A CN 105770808A
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radix
rhizoma
borneol
pasters
bone
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娄峰
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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Abstract

The invention relates to preparation and quality control methods for borneol-musk bone-setting ointment pasters. The borneol-musk bone-setting ointment pasters are medicine having the effects of tonifying the liver and kidney, warming channels and dissipating blood stasis, strengthening tendons and bones and treating bone diseases. The borneol-musk bone-setting ointment pasters are used for solving problems of other technologies in the treatment of disease symptoms at present. The borneol-musk bone-setting ointment pasters are prepared from borneol, spatholobus suberectus, dried whole scorpions, centipedes, cassia twigs, notopterygium root, heracleum hemsleyanum, radix Saposhnikoviae, radix clematidis, radix gentianae macrophyllae, peach kernels, safflowers, rhizoma chuanxiong, radix paeoniae rubra, resina draconis, native copper, hippocampi, sea dragons, cortex eucommiae, taxillus chinensis, rhizoma Wenyujin concisum, black-tail snake, multibanded krait, pine nodular branches, rhizoma zingiberis, poria cocos, artificial musk, chaenomeles lagenaria, glycyrrhiza uralensis, cinnabar and compound of glauber-salt and liquorice.

Description

Prepared by ice Moschus moschiferous bone setting plaster, method of quality control
Prepared by technical field: the present invention relates to the invigorating the liver and kidney of a kind of benefit, warming the meridian dissipating blood stasis, bone and muscle strengthening, treat the medicine of osteopathia, especially ice Moschus moschiferous bone setting plaster, method of quality control.
Background technology: prolapse of lumbar intervertebral disc means owing to lumbar nucleus pulposus highlights the series of symptoms oppressing nervous tissue about and cause.Clinical statistics shows, it is one of the most common illness of Orthopaedics Clinic that lumbar intervertebral disc prominent (taking off) goes out disease, is also the most common reason of lumbago and skelalgia.The medicine treating above disease is varied, has unguentum, tablet, injection, capsule etc., and these medicines alleviate the pain of patient to a certain extent, but due to the difference of formula and preparation method, has plenty of preparation complexity, and production cost is high, and patient can not afford；Have plenty of unsatisfactory curative effect, do not reach the requirement of patient.
nullSummary of the invention: it is an object of the invention to provide preparation method simple，Prepared by the relatively low ice Moschus moschiferous bone setting plaster of expense of curing the disease、Method of quality control，Other technology at present that it solves treats a difficult problem for above disease，The object of the present invention is achieved like this，It is made up of Borneolum Syntheticum 300g Caulis Spatholobi 125g Scorpio 125g Scolopendra 125g Ramulus Cinnamomi 125g Rhizoma Et Radix Notopterygii 125g Radix Angelicae Pubescentis 125g Radix Saposhnikoviae 125g Radix Clematidis 125g Radix Gentianae Macrophyllae 125g Semen Persicae 125g Flos Carthami 125g Rhizoma Chuanxiong 125g Radix Paeoniae Rubra 125g Sanguis Draxonis 125g Pyritum 125g Hippocampus 125g Solenognathus 125g Cortex Eucommiae 125g Herba Taxilli 125g Rhizoma Wenyujin Concisum 125g Zaocys 125g Bungarus Parvus 125g Pine Nodular Branch 125g Rhizoma Zingiberis 125g Poria 125g artificial Moschus 10g Fructus Chaenomelis 125g Radix Glycyrrhizae 125g Cinnabaris 50g Matrii Sulfas Exsiccatus 125g，Its preparation method is: the first step is by artificial Moschus、Borneolum Syntheticum、Cinnabaris、Sanguis Draxonis is ground into fine powder respectively，Cross 100 mesh sieves；Second step, by remaining 27 taste medicine, is given as one thinks fit cataclasm, fried withered with putting in pot with Oleum Sesami 30kg, removes slag, filters, and refining is to dripping into pearl；3rd step separately takes Plumbum preparatium 14kg, adds in oil and stirs evenly, and receives cream.Cream is soaked in water by the 4th step；5th step adds above-mentioned powder, stirs evenly, share on cloth, make 1000, to obtain final product after taking the fusing of cream slow fire.
Character: this product is the black plaster spread out on cloth.
Differentiating: take this product one, shred, put in flask, add suitable quantity of water, connect volatile oil determination apparatus and reflux condensing tube, automatic extractor upper end adds water and makes to be full of the scale part of volatile oil determination apparatus, then adds ethyl acetate 2ml.Heating keeps micro-boiling about 1 hour, stops heating, divides and takes ethyl acetate solution need testing solution.Separately take Borneolum Syntheticum reference substance ethyl acetate and make every 1ml solution containing 2mg, as reference substance solution.Test according to thin layer chromatography (2015 editions four general rules 0502 of Chinese Pharmacopoeia), draw need testing solution and reference substance solution 5-10 μ l, put respectively on same silica gel g thin-layer plate, with petroleum ether (30-60 DEG C)-ethyl acetate (10:1) for developing solvent, launch, take out, dry, spray is with 10% phosphomolybdic acid ethanol solution, and hot blast is blown to clear spot.In test sample chromatograph, the speckle of aobvious same color on position corresponding with reference substance chromatograph.
Check: every regulation (2015 editions four general rules 0186 of Chinese Pharmacopoeia) relevant under plaster item should be met
Function cures mainly: benefit invigorating the liver and kidney, warming the meridian dissipating blood stasis, bone and muscle strengthening.Cure mainly the diseases such as intervertebral disk hernia, all kinds of hyperosteogenys, spinal canal stenosis, femur head necrosis.
Usage and dosage: softening of heating, is affixed on affected part.
Specification: every net weight 38g.
Points for attention: avoid and suffer from cold, make moist and strenuous exercise.
Storage: airtight, puts shady and cool dry place.
Pathology selects: 1, diagnostic criteria, lumbago and sciatic nerve distributed areas pain；Get involved the obvious tenderness of side between spinous process, often companion's Ipsilateral lower limb radiating pain；Straight-leg raising test, strengthens the test positive；Ipsilateral lower limb cenesthesia obstacle, muscular strength go down, tendon reflex weakens or disappears；Waist section scoliosis, lumbar vertebra limitation of activity；X-ray anterioposterior and lateral film prompting lumbar lateral curvature, physiology lordosis reduce or disappearance, narrowing of intervertebral space etc.；CT/MRI prompting has intervertebral disk hernia.
Clinical case is originated: 308 examples transferred from other special chinic and general out patient service, wherein male 228 example, women 80 example；The oldest 49 years old, minimum 20 years old；The course of disease is the longest 4 years, the shortest 2 days.
Therapy: patient monthly one forces on, simultaneously the repercussive ball that cures the wound of oral our unit, every day 3 times, each 6-12 grain；January is a course for the treatment of, treats the 2-3 course for the treatment of.
Curative effect determinate standard: clinical cure: within medication three months, lumbago and skelalgia disappears substantially, straight-leg raising test is positive, recovers normal operation, the evaluation criterion total score 85-100 person of dividing.
Effective: within medication three months, lumbago and skelalgia major part disappears, and without obvious pressure pain point, Negative straight-leg raising test, can be engaged in general muscle power work, and evaluation criterion total score is the 60-84 person of dividing.
Effective: within medication three months, lumbago and skelalgia alleviates, straight-leg raising test probable positive, light muscle power work can be engaged in, evaluation criterion total score is the 30-59 person of dividing.
Invalid: within medication three months, lumbago and skelalgia is without substantially alleviating, it is impossible to work, and evaluation criterion total score is less than 30 points persons.
The present invention is through practice for a long time, and curative effect is desirable；Effect is rapidly；Method is simple；Low cost；Reliable in quality；Section emulates the advanced；Safe no pain；Relapse rate is low.
nullDetailed description of the invention: embodiment 1、The present invention is by Borneolum Syntheticum 200-400g Caulis Spatholobi 100-150g Scorpio 100-150g、Scolopendra 100-150g、Ramulus Cinnamomi 100-150g、Rhizoma Et Radix Notopterygii 100-150g、Radix Angelicae Pubescentis 100-150g、Radix Saposhnikoviae 100-150g、Radix Clematidis 100-150g、Radix Gentianae Macrophyllae 100-150g、Semen Persicae 100-150g、Flos Carthami 100-150g、Rhizoma Chuanxiong 100-150g、Radix Paeoniae Rubra 100-150g、Sanguis Draxonis 100-150g、Pyritum 100-150g、Hippocampus 100-150g、Solenognathus 100-150g、Cortex Eucommiae 100-150g、Herba Taxilli 100-150g、Rhizoma Wenyujin Concisum 100-150g、Zaocys 100-150g、Bungarus Parvus 100-150g、Pine Nodular Branch 100-150g、Rhizoma Zingiberis 100-150g、Poria 100-150g、Artificial Moschus 5-15 Fructus Chaenomelis 100-150g、Radix Glycyrrhizae 100-150g、Cinnabaris 40-60g、Matrii Sulfas Exsiccatus 100-150g makes，Its preparation method is: the first step is by artificial Moschus、Borneolum Syntheticum、Cinnabaris、Sanguis Draxonis is ground into fine powder respectively，Cross 100 mesh sieves；Second step, by remaining 27 taste medicine, is given as one thinks fit cataclasm, fried withered with putting in pot with Oleum Sesami 30kg, removes slag, filters, and refining is to dripping into pearl；3rd step separately takes Plumbum preparatium 14kg, adds in oil and stirs evenly, and receives cream；Cream is soaked in water by the 4th step；5th step adds above-mentioned powder, stirs evenly, share on cloth, make 1000, to obtain final product after taking the fusing of cream slow fire.
nullEmbodiment 2、The present invention is by Borneolum Syntheticum 250-350g Caulis Spatholobi 120-130g、Scorpio 120-130g、Scolopendra 120-130g、Ramulus Cinnamomi 120-130g、Rhizoma Et Radix Notopterygii 120-130g、Radix Angelicae Pubescentis 120-130g、Radix Saposhnikoviae 120-130g、Radix Clematidis 120-130g、Radix Gentianae Macrophyllae 120-130g、Semen Persicae 120-130g、Flos Carthami 120-130g、Rhizoma Chuanxiong 120-130g、Radix Paeoniae Rubra 120-130g、Sanguis Draxonis 120-130g、Pyritum 120-130g、Hippocampus 120-130g、Solenognathus 120-130g、Cortex Eucommiae 120-130g、Herba Taxilli 120-130g、Rhizoma Wenyujin Concisum 120-130g、Zaocys 120-130g、Bungarus Parvus 120-130g、Pine Nodular Branch 120-130g、Rhizoma Zingiberis 120-130g、Poria 120-130g、Artificial Moschus 9-11 Fructus Chaenomelis 120-130g、Radix Glycyrrhizae 120-130g、Cinnabaris 45-55g、Matrii Sulfas Exsiccatus 120-130g makes.
Embodiment 3, the present invention are made up of Borneolum Syntheticum 300g Caulis Spatholobi 125g Scorpio 125g Scolopendra 125g Ramulus Cinnamomi 125g Rhizoma Et Radix Notopterygii 125g Radix Angelicae Pubescentis 125g Radix Saposhnikoviae 125g Radix Clematidis 125g Radix Gentianae Macrophyllae 125g Semen Persicae 125g Flos Carthami 125g Rhizoma Chuanxiong 125g Radix Paeoniae Rubra 125g Sanguis Draxonis 125g Pyritum 125g Hippocampus 125g Solenognathus 125g Cortex Eucommiae 125g Herba Taxilli 125g Rhizoma Wenyujin Concisum 125g Zaocys 125g Bungarus Parvus 125g Pine Nodular Branch 125g Rhizoma Zingiberis 125g Poria 125g artificial Moschus 10g Fructus Chaenomelis 125g Radix Glycyrrhizae 125g Cinnabaris 50g Matrii Sulfas Exsiccatus 125g.
Embodiment 4, the present invention method of quality control, this product character is the black plaster for spreading out on cloth；Differentiating: take this product one, shred, put in flask, add suitable quantity of water, connect volatile oil determination apparatus and reflux condensing tube, automatic extractor upper end adds water and makes to be full of the scale part of volatile oil determination apparatus, then adds ethyl acetate 2ml；Heating keeps micro-boiling about 1 hour, stops heating, divides and takes ethyl acetate solution need testing solution；Separately take Borneolum Syntheticum reference substance ethyl acetate and make every 1ml solution containing 2mg, as reference substance solution；Test according to thin layer chromatography (2015 editions four general rules 0502 of Chinese Pharmacopoeia), draw need testing solution and reference substance solution 5-10 μ l, put respectively on same silica gel g thin-layer plate, with petroleum ether (30-60 DEG C)-ethyl acetate (10:1) for developing solvent, launch, take out, dry, spray is with 10% phosphomolybdic acid ethanol solution, and hot blast is blown to clear spot；In test sample chromatograph, the speckle of aobvious same color on position corresponding with reference substance chromatograph；Check: every regulation (2015 editions four general rules 0186 of Chinese Pharmacopoeia) relevant under plaster item should be met.

Claims (4)

  1. null1. ice Moschus moschiferous bone setting plaster，It is characterized in that: it is by Borneolum Syntheticum 200-400g Caulis Spatholobi 100-150g Scorpio 100-150g、Scolopendra 100-150g、Ramulus Cinnamomi 100-150g、Rhizoma Et Radix Notopterygii 100-150g、Radix Angelicae Pubescentis 100-150g、Radix Saposhnikoviae 100-150g、Radix Clematidis 100-150g、Radix Gentianae Macrophyllae 100-150g、Semen Persicae 100-150g、Flos Carthami 100-150g、Rhizoma Chuanxiong 100-150g、Radix Paeoniae Rubra 100-150g、Sanguis Draxonis 100-150g、Pyritum 100-150g、Hippocampus 100-150g、Solenognathus 100-150g、Cortex Eucommiae 100-150g、Herba Taxilli 100-150g、Rhizoma Wenyujin Concisum 100-150g、Zaocys 100-150g、Bungarus Parvus 100-150g、Pine Nodular Branch 100-150g、Rhizoma Zingiberis 100-150g、Poria 100-150g、Artificial Moschus 5-15 Fructus Chaenomelis 100-150g、Radix Glycyrrhizae 100-150g、Cinnabaris 40-60g、Matrii Sulfas Exsiccatus 100-150g makes，Its preparation method is: the first step is by artificial Moschus、Borneolum Syntheticum、Cinnabaris、Sanguis Draxonis is ground into fine powder respectively，Cross 100 mesh sieves；Second step, by remaining 27 taste medicine, is given as one thinks fit cataclasm, fried withered with putting in pot with Oleum Sesami 30kg, removes slag, filters, and refining is to dripping into pearl；3rd step separately takes Plumbum preparatium 14kg, adds in oil and stirs evenly, and receives cream；Cream is soaked in water by the 4th step；5th step adds above-mentioned powder, stirs evenly, share on cloth, make 1000, to obtain final product after taking the fusing of cream slow fire.
  2. null2. ice Moschus moschiferous bone setting plaster according to claim 1，It is characterized in that: it is by Borneolum Syntheticum 250-350g Caulis Spatholobi 120-130g、Scorpio 120-130g、Scolopendra 120-130g、Ramulus Cinnamomi 120-130g、Rhizoma Et Radix Notopterygii 120-130g、Radix Angelicae Pubescentis 120-130g、Radix Saposhnikoviae 120-130g、Radix Clematidis 120-130g、Radix Gentianae Macrophyllae 120-130g、Semen Persicae 120-130g、Flos Carthami 120-130g、Rhizoma Chuanxiong 120-130g、Radix Paeoniae Rubra 120-130g、Sanguis Draxonis 120-130g、Pyritum 120-130g、Hippocampus 120-130g、Solenognathus 120-130g、Cortex Eucommiae 120-130g、Herba Taxilli 120-130g、Rhizoma Wenyujin Concisum 120-130g、Zaocys 120-130g、Bungarus Parvus 120-130g、Pine Nodular Branch 120-130g、Rhizoma Zingiberis 120-130g、Poria 120-130g、Artificial Moschus 9-11 Fructus Chaenomelis 120-130g、Radix Glycyrrhizae 120-130g、Cinnabaris 45-55g、Matrii Sulfas Exsiccatus 120-130g makes.
  3. 3. ice Moschus moschiferous bone setting plaster according to claim 1, is characterized in that: it is made up of Borneolum Syntheticum 300g Caulis Spatholobi 125g Scorpio 125g Scolopendra 125g Ramulus Cinnamomi 125g Rhizoma Et Radix Notopterygii 125g Radix Angelicae Pubescentis 125g Radix Saposhnikoviae 125g Radix Clematidis 125g Radix Gentianae Macrophyllae 125g Semen Persicae 125g Flos Carthami 125g Rhizoma Chuanxiong 125g Radix Paeoniae Rubra 125g Sanguis Draxonis 125g Pyritum 125g Hippocampus 125g Solenognathus 125g Cortex Eucommiae 125g Herba Taxilli 125g Rhizoma Wenyujin Concisum 125g Zaocys 125g Bungarus Parvus 125g Pine Nodular Branch 125g Rhizoma Zingiberis 125g Poria 125g artificial Moschus 10g Fructus Chaenomelis 125g Radix Glycyrrhizae 125g Cinnabaris 50g Matrii Sulfas Exsiccatus 125g.
  4. 4. the method for quality control of ice Moschus moschiferous bone setting plaster described in claim 1, is characterized in that: this product character is the black plaster spread out on cloth；Differentiating: take this product one, shred, put in flask, add suitable quantity of water, connect volatile oil determination apparatus and reflux condensing tube, automatic extractor upper end adds water and makes to be full of the scale part of volatile oil determination apparatus, then adds ethyl acetate 2ml；Heating keeps micro-boiling about 1 hour, stops heating, divides and takes ethyl acetate solution need testing solution；Separately take Borneolum Syntheticum reference substance ethyl acetate and make every 1ml solution containing 2mg, as reference substance solution；Test according to thin layer chromatography (2015 editions four general rules 0502 of Chinese Pharmacopoeia), draw need testing solution and reference substance solution 5-10 μ l, put respectively on same silica gel g thin-layer plate, with petroleum ether (30-60 DEG C)-ethyl acetate (10:1) for developing solvent, launch, take out, dry, spray is with 10% phosphomolybdic acid ethanol solution, and hot blast is blown to clear spot；In test sample chromatograph, the speckle of aobvious same color on position corresponding with reference substance chromatograph；Check: every regulation (2015 editions four general rules 0186 of Chinese Pharmacopoeia) relevant under plaster item should be met.
CN201610172791.5A 2016-03-24 2016-03-24 Preparation and quality control methods for borneol-musk bone-setting ointment pasters Pending CN105770808A (en)

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Application publication date: 20160720