CN105770794A - Medicine used for treating calf diarrhea and preparing method thereof - Google Patents

Abstract

The invention provides medicine used for treating calf diarrhea and a preparing method thereof.The medicine is prepared from medcinal evodia fruit, semen canavaliae, ginger, caulis bambusae in taeniis, mongollian thyme herbs, acorn seeds, cacti, vernonia patula, schisandra rubriflora(Franch.)rehd.etwils, polygonum hydropiper, mosla chinensis, daghestan sweet clover herbs, melastoma dodecandrum roots, puberulous glochidion herb roots, white pomegranate flowers, menyanthes trifoliate, radix polygonati officinalis, clerodendrum bungei roots and Chinese pyrola herbs.The medicine has the advantages of having the effects of warming interior, stopping diarrhea, resolving dampness, astringing the intestine, tonifying the spleen and strengthening the kidney, while the calf diarrhea is treated, the disease-resisting ability of calves can be improved, the immunity of the calves is enhanced, and the medicine has the functions of being purely natural, free from drug resistance, resides and toxic and side effects and high in targeted performance, and has the advantages of directly reaching nidi and being remarkable in treatment effect.

Description

A kind of for medicine treating calf diarrhea and preparation method thereof

Technical field

The present invention relates to domestic animal medicine technical field, particularly to a kind of for medicine treating calf diarrhea and preparation method thereof.

Background technology

Calf diarrhea is had loose bowels also known as calf, all can occur throughout the year, is a kind of gastrointestinal disease of often sending out of calf.Calf often after birth 2 ~ 3d start morbidity, to the growth of calf, grow, survive etc. and to have a significant impact.When jumpbogroup is raised, calf diarrhea incidence rate often reaches 90% ~ 100%, and mortality rate reaches as high as more than 50%, threatens very big to the development of milk industry.

Diagnosis: mainly can make diagnosis according to medical history, clinical symptoms.But make a definite diagnosis, it is necessary to according to pathological change, the inspection of enteric microorganism, ill calf is contained liquefaction and tests a light horse cart stool examination, necessary right, the milk to cow with a calf at foot, special another II is that breast does not carry out picking up and tests analysis (digestible protein, fat, acidity etc.) ', and hindered result carries out comprehensive diagnos.Except except discriminating clinically, epidemiology notes, it is possible to reference frame is provided.The diarrhoea caused such as escherichia coli mostly occurs at l ~ 3 age in days;What virus caused is mainly in winter, and coronavirus causes the calf within 3 monthly ages to fall ill more, and rotavirus mostly occurs at 4 ~ 14 ages in days;Cryptosporidium spp 6 ~ 17 age in days calf, without seasonal;As being break out, any age all can occur, and has heating and high mortality, it may be possible to Salmonella causes, and can identify by feces row antibacterial culturing;There is serious enterohemorrhagic toxemia in calf as good in nutrition, dead rapidly, then be probably B or C type bacillus aerogenes capsulatus and infect, available fecal smear inspection;As because of diarrhoea life-time service antibacterial and become chronic diarrhea, it is possible to for the Candida in Bacillus proteus or Rhodopseudomonas and mycete.

Owing to causing the reason of calf diarrhea to be many-sided, therefore the treatment to primary disease, should take to include to improve sanitary condition, the composite treatment of the measure such as bait therapy, pharmacotherapy, fluid replacement therapy.Safeguard cardiovascular function, improve substance metabolism, inhibiting bacteria and diminishing inflammation, it is prevented that acidosis, prevent gastrointestinal fermentation and decay process is the principle treating calf diarrhea.

Western medical treatment method, is not effective completely on the one hand to disease, toxin can be caused to accumulate on the other hand, and therefore, the traditional Chinese medical science has very big advantage.

Summary of the invention

The technical problem to be solved is to provide a kind of for medicine treating calf diarrhea and preparation method thereof.

In order to solve above-mentioned technical problem, the invention provides a kind of medicine for treating calf diarrhea, wherein, described medicine includes following raw medicinal material: Fructus Evodiae, Semen Canavaliae, Rhizoma Zingiberis Recens, Caulis Bambusae In Taenia, Herba Thymi, Semen querci dentatae, Radix et Caulis Opuntiae Dillenii, Herba Vernoniae Patulae, the Yunnan five tastes, Herba Polygoni hydropiperis, Shi Xiang, Herba Meliloti Suaveolentis, DIGEN, Radix glochidionis puberi, Flos Punicae Albescentis, Herba menyanthis, Rhizoma Polygonati Odorati, Radix clerodendri bungei and Herba Pyrolae.

Wherein, in described medicine, the parts by weight of each raw medicinal material are: Fructus Evodiae 2-4 weight portion, Semen Canavaliae 10-20 weight portion, Rhizoma Zingiberis Recens 5-10 weight portion, Caulis Bambusae In Taenia 4-8 weight portion, Herba Thymi 2-3 weight portion, Semen querci dentatae 15-20 weight portion, Radix et Caulis Opuntiae Dillenii 10-20 weight portion, Herba Vernoniae Patulae 12-24 weight portion, Yunnan five tastes 15-24 weight portion, Herba Polygoni hydropiperis 10-15 weight portion, stone perfume (or spice) 15-20 weight portion, Herba Meliloti Suaveolentis 10-15 weight portion, DIGEN 15-20 weight portion, Radix glochidionis puberi 2-4 weight portion, Flos Punicae Albescentis 10-20 weight portion, Herba menyanthis 10-20 weight portion, Rhizoma Polygonati Odorati 5-10 weight portion, Radix clerodendri bungei 4-8 weight portion and Herba Pyrolae 10-15 weight portion.

Wherein, in described medicine, the parts by weight of each raw medicinal material are: Fructus Evodiae 3 weight portion, Semen Canavaliae 16 weight portion, Rhizoma Zingiberis Recens 7 weight portion, Caulis Bambusae In Taenia 6 weight portion, Herba Thymi 2 weight portion, Semen querci dentatae 16 weight portion, Radix et Caulis Opuntiae Dillenii 16 weight portion, Herba Vernoniae Patulae 18 weight portion, the Yunnan five tastes 18 weight portion, Herba Polygoni hydropiperis 13 weight portion, Shi Xiang 17 weight portion, Herba Meliloti Suaveolentis 12 weight portion, DIGEN 18 weight portion, Radix glochidionis puberi 3 weight portion, Flos Punicae Albescentis 16 weight portion, Herba menyanthis 17 weight portion, Rhizoma Polygonati Odorati 8 weight portion, Radix clerodendri bungei 6 weight portion and Herba Pyrolae 12 weight portion.

In order to achieve the above object, the preparation method that present invention also offers the described medicine for treating calf diarrhea, wherein, its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；

3rd step, adds the starch relative to its quality 2～4 times in the micropowders obtained by second step, mixing, it is thus achieved that medicine.

The invention has the beneficial effects as follows: this medicine has effect of warming the interior antidiarrheal, removing dampness astringing intestine to stop diarrhea, the strong kidney of spleen reinforcing, while treatment calf diarrhea, the resistance against diseases of cattle can be improved, strengthen its immunity, in treatment calf diarrhea, there is pure natural, have no drug resistance, the advantageous feature such as noresidue, has no side effect, and with strong points, through focus is evident in efficacy.

Detailed description of the invention

The invention provides a kind of medicine for treating calf diarrhea, there is effect of warming the interior antidiarrheal, removing dampness astringing intestine to stop diarrhea, the strong kidney of spleen reinforcing, wherein, including Fructus Evodiae, Semen Canavaliae, Rhizoma Zingiberis Recens, Caulis Bambusae In Taenia, Herba Thymi, Semen querci dentatae, Radix et Caulis Opuntiae Dillenii, Herba Vernoniae Patulae, the Yunnan five tastes, Herba Polygoni hydropiperis, Shi Xiang, Herba Meliloti Suaveolentis, DIGEN, Radix glochidionis puberi, Flos Punicae Albescentis, Herba menyanthis, Rhizoma Polygonati Odorati, Radix clerodendri bungei and Herba Pyrolae.

Wherein, Fructus Evodiae, Semen Canavaliae, Rhizoma Zingiberis Recens, Caulis Bambusae In Taenia, Herba Thymi, Semen querci dentatae, Radix et Caulis Opuntiae Dillenii, Herba Vernoniae Patulae, Yunnan five tastes warming the interior antidiarrheal；Herba Polygoni hydropiperis, Shi Xiang, Herba Meliloti Suaveolentis, DIGEN, Radix glochidionis puberi, Flos Punicae Albescentis removing dampness astringing intestine to stop diarrhea；Herba menyanthis, Rhizoma Polygonati Odorati, Radix clerodendri bungei, the strong kidney of Herba Pyrolae spleen reinforcing.Ingredients scientific matching, reaches the effect for the treatment of calf diarrhea.

Now each taste medicine is described below:

Fructus Evodiae: [nature and flavor] are pungent, bitter, heat.[return through] returns liver, spleen, stomach, kidney channel.[function cures mainly] dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomits acid regurgitation, Diarrhoea, external treatment aphtha；Hypertension.

Semen Canavaliae: nature and flavor] sweet, temperature.[return through] returns stomach, kidney channel.[function cures mainly] warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, only oh.For deficiency and coldness singultus, vomiting.

Rhizoma Zingiberis Recens: [nature and flavor] are pungent, tepor.[return through] returns lung, spleen, stomach warp.[function cures mainly] induces sweat cold expelling, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed.

Caulis Bambusae In Taenia: [nature and flavor] are sweet, are slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement are lost in palpitation with fear.

Herba Thymi: [nature and flavor] " are praised and helped book on Chinese herbal medicine ": " acrid in the mouth, temperature." [function cures mainly] warming spleen and stomach for dispelling cold, wind dispelling pain relieving.Control tell inverse, stomachache, have loose bowels, lack of appetite painful abdominal mass is swollen, cough due to wind and cold, and pharyngeal swelling is had a toothache, general pain, skin pruritus.

Semen querci dentatae: [nature and flavor] are bitter；Puckery；Property is put down.[return through] spleen；Stomach；Large intestine channel.[function cures mainly] relieving diarrhea with astringents.Main diarrhoea；Dysentery.

Radix et Caulis Opuntiae Dillenii: [nature and flavor] are bitter, cool.[function cures mainly] heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, benefiting stomach and stopping pain, antitussive.For taste-blindness rate, acute dysentery, cough；Mumps, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald are controlled in external.

Herba Vernoniae Patulae: [nature and flavor] " Guangxi Chinese herbal medicine ": " bitter, flat, nontoxic." [function cures mainly] controls anemopyretic cold, malaria, diarrhea of heat type, headache due to hyperactivity of liver-YANG.1. " register planted by Guangxi medicine ": " control cold and heat, snakebite, malaria." 2. " Guangxi Chinese herbal medicine ": " clearing away heat to stop diarrhea.Control diarrhea of heat type, headache, cold anemopyretic."

The Yunnan five tastes: [nature and flavor] acid；Sweet；Warm in nature.[return through] lung；The heart；Kidney channel.[function cures mainly] restrains astringent or styptic treatment for spontaneous sweating；Supplementing QI for promoting the production of body fluid；Kidney calming.Main chronic cough dyspnea due to deficiency；Emission；Enuresis frequent micturition；Incessant chronic diarrhea；Spontaneous perspiration；Night sweat；Tianjin wound is thirsty；Lose heart deficient pulse；Interior-heat is quenched one's thirst；Palpitation and insomnia.

Herba Polygoni hydropiperis: [nature and flavor] are pungent, flat.1. " a thousand pieces of gold dietetic therapy ": " pungent." 2. " Japan hanako materia medica ": " acrid in the mouth, cold, nontoxic." 3. " detailed outline ": " Folium Polygonum, pungent, temperature, nontoxic." 4. " book on Chinese herbal medicine asks former ": " is bitter wet, flat." [function cures mainly] removing dampness, row is stagnant, dispels the wind, detumescence.Control the dirty stomachache of acute diseases such as cholera and sunstroke, convulsion of vomiting and diarrhoea, have loose bowels, dysentery, rheumatism, beriberi, carbuncle, scabies, traumatic injury.

Shi Xiang: [nature and flavor] work hard, temperature.1. " Kai Baoben gill fungus ": " acrid in the mouth is fragrant, temperature, nontoxic." 2. " Zhejiang conventional medical herbs among the people ": " slightly warm in nature, acrid in the mouth." [function cures mainly] drives away summer heat, and invigorates blood circulation, and regulates the flow of vital energy, removing dampness.Controlling Xia Yue flu, heatstroke vomiting and nausea, stomachache is had loose bowels, traumatic injury stasis of blood pain, eczema, furuncle and phyma.

Herba Meliloti Suaveolentis: [nature and flavor] work hard, cool.1. " Traditional Chinese Medicine in Sichuan will ": " bitter light, cool, nontoxic." 2. " Chinese herbal medicine is commonly used in Shanghai ": " is pungent, flat." [function cures mainly] heat clearing away, removing toxic substances, removing dampness, parasite killing.Control summer-heat uncomfortable in chest, malaria, dysentery, gonorrhea, sores ulceration of skin.

DIGEN: [nature and flavor] " east, Fujian book on Chinese herbal medicine ": " property is put down, the micro-sweet acid of taste." [return through] " east, Fujian book on Chinese herbal medicine ": " enters liver, kidney, spleen, lung four warp." [function cures mainly] invigorates blood circulation, hemostasis, dampness removing, removing toxic substances.Control dysmenorrhea, puerperal abdonimal pain, metrorrhagia, leucorrhea, dysentery, scrofula, toothache.

Radix glochidionis puberi: [nature and flavor] are bitter is flat.1. " Fujian traditional herbal medicine ": " micro-hardship, flat." 2. " Guizhou folk medicine ": " tepor, micro-puckery, nontoxic." 3. " Traditional Chinese Medicine in Sichuan will ": " bitter in the mouth, cool in nature, slightly poisonous." [function cures mainly] clearing away heat-damp and promoting diuresis, promoting blood circulation and detoxication.Control dysentery, malaria, jaundice, nebulousurine, epersalgia cough, rheumatic arthralgia, metrorrhagia, leukorrhagia, laryngalgia, toothache, carbuncle, scrofula, traumatic injury.

Flos Punicae Albescentis: nature and flavor] sour sweet, flat.1. " Traditional Chinese Medicine in Sichuan will ": " warm in nature, sour in the mouth is sweet micro-puckery, nontoxic." 2. " Fujian Chinese herbal medicine ": " sweet micro-hardship, flat." [function cures mainly] stops blooding, astringing intestine to stop diarrhea.Control hemoptysis, spit blood, epistaxis, have blood in stool, chronic dysentery.

Herba menyanthis: [nature and flavor] sweet, bitter, cold.[function cures mainly] clearing away heat and promoting diuresis, stomach invigorating, calm the nerves.For gastritis, dyspepsia, cholecystitis, jaundice, hypertension, cardiopalmus, insomnia.

Rhizoma Polygonati Odorati: [nature and flavor] are sweet, are slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Hindering for lung stomach-Yin, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.

Radix clerodendri bungei: [nature and flavor] work hard, temperature.1. " classify herbal ": " lightly seasoned hardship." 2. " Fujian traditional herbal medicine ": " is pungent, temperature." 3. " Shaanxi Chinese herbal medicine ": " toil, flat." [function cures mainly] circulation of qi promoting spleen invigorating, dispel the wind suppressing the hyperactive liver, subduing swelling and detoxicating.Controlling metrorrhagia, leucorrhea, dizzy, void is coughed, hypertension, rheumatalgia, beriberi, urticaria, carbuncle, hemorrhoid.

Herba Pyrolae: [nature and flavor] sweetness and bitterness, temperature.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature flat, acrid in the mouth." 2. " Shaanxi Chinese herbal medicine ": " is pained, flat." 3. " Shanxi Chinese herbal medicine ": " is sweet, temperature." [return through] " Zhiwu Mingshi Tukao ": " enters liver, kidney two warp." [function cures mainly] qi-restoratives, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation control weak cough, over-strained hemoptysis, rheumatic arthritis, metrorrhagia, leucorrhea, traumatic hemorrhage.

Described medicine is only made up of above-mentioned raw materials medical material.

Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.

Embodiment 1

Formula: Fructus Evodiae 2g, Semen Canavaliae 10g, Rhizoma Zingiberis Recens 5g, Caulis Bambusae In Taenia 4g, Herba Thymi 2g, Semen querci dentatae 15g, Radix et Caulis Opuntiae Dillenii 10g, Herba Vernoniae Patulae 12g, Yunnan five tastes 15g, Herba Polygoni hydropiperis 10g, Shi Xiang 15g, Herba Meliloti Suaveolentis 10g, DIGEN 15g, Radix glochidionis puberi 2g, Flos Punicae Albescentis 10g, Herba menyanthis 10g, Rhizoma Polygonati Odorati 5g, Radix clerodendri bungei 4g and Herba Pyrolae 10g.

Its preparation process is:

The first step, mixes described each raw medicinal material, adds the ethanol that determining alcohol is 90% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 90% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2 hours, pulverizes, sieves, it is thus achieved that the micropowders of 350 orders；

3rd step, adds the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, it is thus achieved that medicine.

Embodiment 2

Formula: Fructus Evodiae 4g, Semen Canavaliae 20g, Rhizoma Zingiberis Recens 10g, Caulis Bambusae In Taenia 8g, Herba Thymi 3g, Semen querci dentatae 20g, Radix et Caulis Opuntiae Dillenii 20g, Herba Vernoniae Patulae 24g, Yunnan five tastes 24g, Herba Polygoni hydropiperis 15g, Shi Xiang 20g, Herba Meliloti Suaveolentis 15g, DIGEN 20g, Radix glochidionis puberi 4g, Flos Punicae Albescentis 20g, Herba menyanthis 20g, Rhizoma Polygonati Odorati 10g, Radix clerodendri bungei 8g and Herba Pyrolae 15g.

Its preparation process is:

The first step, mixes described each raw medicinal material, adds the ethanol that determining alcohol is 90% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 95% relative to described medicinal residues quality 1 times, be heated to reflux 3 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2 hours, pulverizes, sieves, it is thus achieved that the micropowders of 400 orders；

3rd step, adds the starch relative to its quality 4 times in the micropowders obtained by second step, mixing, it is thus achieved that medicine.

Embodiment 3

Formula: Fructus Evodiae 3g, Semen Canavaliae 16g, Rhizoma Zingiberis Recens 7g, Caulis Bambusae In Taenia 6g, Herba Thymi 2g, Semen querci dentatae 16g, Radix et Caulis Opuntiae Dillenii 16g, Herba Vernoniae Patulae 18g, Yunnan five tastes 18g, Herba Polygoni hydropiperis 13g, Shi Xiang 17g, Herba Meliloti Suaveolentis 12g, DIGEN 18g, Radix glochidionis puberi 3g, Flos Punicae Albescentis 16g, Herba menyanthis 17g, Rhizoma Polygonati Odorati 8g, Radix clerodendri bungei 6g and Herba Pyrolae 12g.

Its preparation process is:

The first step, mixes described each raw medicinal material, adds the ethanol that determining alcohol is 90% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 90% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 2 hours, pulverizes, sieves, it is thus achieved that the micropowders of 300 orders；

3rd step, adds the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, it is thus achieved that medicine.

The toxicity test of medicine

Method one: application NIH mice 40, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity test.Mice is randomly divided into two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment；By the medicine dissolution of embodiment 1 in water, (concentration is 6g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 30g crude drug/kg), matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore the pharmaceutical composition acute toxicity of the present invention is low, clinical drug safety.

Method two: mice is pressed by the medicine of embodiment 2 7g, 14g and 35g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by pharmaceutical composition of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 12 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that the pharmaceutical composition of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.

Contrast test

Experimental animal

500 calves being just born of cattle farm, Jining City, wherein, have 200 calves diarrhoea occur, the tested sick cattle that 200 body weight are more or less the same comes from the cattle of the natural occurrence of this cattle farm, it is classified as 4 groups at random, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group, often group 50.

Test method

Embodiment 1 group: 50 ill cattle of this group, adopts the medicine of embodiment 1 to treat.Medicine is mixed in daily feedstuff according to the ratio of 3:100, normally feeds, carry out 2 days.

Embodiment 2 groups: 50 ill cattle of this group, adopts the medicine of embodiment 2 to treat.Medicine is mixed in daily feedstuff according to the ratio of 3:100, normally feeds, carry out 2 days.

Embodiment 3 groups: 50 ill cattle of this group, adopts the medicine of embodiment 3 to treat.Medicine is mixed in daily feedstuff according to the ratio of 3:100, normally feeds, carry out 2 days.

Matched group: 50 ill cattle of this group, adopts bactrim to treat.Every day, 5g, was administered orally 2 times, and normally fed daily feedstuff simultaneously, carried out 2 days.

Criterion of therapeutical effect

Recovery from illness: symptom is wholly absent；Effectively；Symptom disappears substantially；Invalid: symptom is without improvement.

Therapeutic outcome

Before and after treatment, the situation of record, counts table 1.

The situation before and after treatment that table 1 is respectively organized

Group	Sum	Recovery from illness	Effectively	Invalid
					Embodiment 1 group	50	49(98%)	1(2%)	0(0%)
Embodiment 2 groups	50	50(100%)	0(0%)	0(0%)
					Embodiment 3 groups	50	50(100%)	0(0%)	0(0%)
Matched group	50	35(70%)	10(20%)	5(10%)

Referring to table 1 it can be seen that the treatment situation of embodiment 1 group, embodiment 2 groups and embodiment 3 groups will be better than matched group, it is possible to learn, the medicine of the present invention, on treatment calf diarrhea, therapeutic effect is good, determined curative effect, well improves the state of an illness.

Table 2 is the recovery from illness recurrence contrast of the cattle of each group

Group	Recovery from illness	Recurrence
			Embodiment 1 group	49	0(0%)
Embodiment 2 groups	50	0(0%)
			Embodiment 3 groups	50	0(0%)
Matched group	35	4(11.4%)

Referring to table 2 it can be seen that while the treatment calf diarrhea of embodiment 1 group, embodiment 2 groups and embodiment 3 groups, do not recur.

In sum, medicine of the present invention, on treatment calf diarrhea, therapeutic effect is good, and determined curative effect does not recur.

Citing: there is calf 200 in vaccary, Jining City, 80 symptoms that diarrhoea occurs.Selecting 80 ill cattle to carry out isolation treatment, select the medicine of embodiment 2, be mixed in conventional feed according to the ratio of 3:100 and normally feed, treat 2, recovery from illness is 80, cure rate 100%.Later stage does not recur.

The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (5)

1. the medicine being used for treating calf diarrhea, it is characterized in that, described medicine includes following raw medicinal material: Fructus Evodiae, Semen Canavaliae, Rhizoma Zingiberis Recens, Caulis Bambusae In Taenia, Herba Thymi, Semen querci dentatae, Radix et Caulis Opuntiae Dillenii, Herba Vernoniae Patulae, the Yunnan five tastes, Herba Polygoni hydropiperis, Shi Xiang, Herba Meliloti Suaveolentis, DIGEN, Radix glochidionis puberi, Flos Punicae Albescentis, Herba menyanthis, Rhizoma Polygonati Odorati, Radix clerodendri bungei and Herba Pyrolae.

null2. the medicine for treating calf diarrhea according to claim 1，It is characterized in that，In described medicine, the parts by weight of each raw medicinal material are: Fructus Evodiae 2-4 weight portion、Semen Canavaliae 10-20 weight portion、Rhizoma Zingiberis Recens 5-10 weight portion、Caulis Bambusae In Taenia 4-8 weight portion、Herba Thymi 2-3 weight portion、Semen querci dentatae 15-20 weight portion、Radix et Caulis Opuntiae Dillenii 10-20 weight portion、Herba Vernoniae Patulae 12-24 weight portion、Yunnan five tastes 15-24 weight portion、Herba Polygoni hydropiperis 10-15 weight portion、Stone perfume (or spice) 15-20 weight portion、Herba Meliloti Suaveolentis 10-15 weight portion、DIGEN 15-20 weight portion、Radix glochidionis puberi 2-4 weight portion、Flos Punicae Albescentis 10-20 weight portion、Herba menyanthis 10-20 weight portion、Rhizoma Polygonati Odorati 5-10 weight portion、Radix clerodendri bungei 4-8 weight portion and Herba Pyrolae 10-15 weight portion.

3. the pharmaceutical composition for treating calf diarrhea according to claim 1 and 2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Fructus Evodiae 3 weight portion, Semen Canavaliae 16 weight portion, Rhizoma Zingiberis Recens 7 weight portion, Caulis Bambusae In Taenia 6 weight portion, Herba Thymi 2 weight portion, Semen querci dentatae 16 weight portion, Radix et Caulis Opuntiae Dillenii 16 weight portion, Herba Vernoniae Patulae 18 weight portion, the Yunnan five tastes 18 weight portion, Herba Polygoni hydropiperis 13 weight portion, fragrant 17 weight portions of stone, Herba Meliloti Suaveolentis 12 weight portion, DIGEN 18 weight portion, Radix glochidionis puberi 3 weight portion, Flos Punicae Albescentis 16 weight portion, Herba menyanthis 17 weight portion, Rhizoma Polygonati Odorati 8 weight portion, Radix clerodendri bungei 6 weight portion and Herba Pyrolae 12 weight portion.

4. the medicine for treating calf diarrhea according to any one of claim 1-3, it is characterised in that its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；

3rd step, adds the starch relative to its quality 2～4 times in the micropowders obtained by second step, mixing, it is thus achieved that medicine.

5. the preparation method of the medicine for treating calf diarrhea according to any one of claim 1-4, it is characterised in that its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85～95% relative to mixture quality 2～4 times, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution；Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85～95% relative to described medicinal residues quality 1～2 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution；First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream；

Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders；

3rd step, adds the starch relative to its quality 2～4 times in the micropowders obtained by second step, mixing, it is thus achieved that medicine.