CN105770741A - Traditional Chinese medicine composition for benefiting qi, nourishing blood and adjusting metabolism and preparation and preparation method thereof - Google Patents

Traditional Chinese medicine composition for benefiting qi, nourishing blood and adjusting metabolism and preparation and preparation method thereof Download PDF

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CN105770741A
CN105770741A CN201610218053.XA CN201610218053A CN105770741A CN 105770741 A CN105770741 A CN 105770741A CN 201610218053 A CN201610218053 A CN 201610218053A CN 105770741 A CN105770741 A CN 105770741A
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benefiting
weight
metabolism
chinese medicine
blood
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张德龙
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Beijing Yuxintang Biotechnology Co Ltd
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Beijing Yuxintang Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K36/06—Fungi, e.g. yeasts
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Abstract

The invention relates to a traditional Chinese medicine composition for benefiting qi, nourishing blood and adjusting metabolism and a preparation and preparation method thereof. The composition is mainly prepared from anisetree bark, cordyceps militaris, hericium erinaceus, radix curcumae, chamomile, black mulberries, fruits of Chinese wolfberry, fruits of Chinese magnoliavine, fructus cannabis, agastache rugosus, white poria, pericarpium citri reticulatae and peach kernels according to the certain parts by weight. The composition can coordinate the body functions on the whole, achieves qi and blood regulation, achieves tonification and purgation in combination, and timely remove virus and immunity compositions in time by regulating qi flowing in the channels, activating blood, dredging collaterals and dredging internal and external microchannels and a human excretory system, and therefore the effects of removing pathogenic factors for the reinforcement of vital qi, regulating qi, activating blood and adjusting metabolism are achieved, blood glucose and blood fat are lowered, the effects of controlling weight growth, adjusting insulin and intestinal flora and the like are obvious, and the good effect is achieved for treating metabolic syndromes.

Description

A kind of benefiting qi and nourishing blood, the Chinese medicine composition regulating metabolism and preparation thereof and method for making
Technical field
The invention belongs to field of pharmaceutical preparations, particularly to a kind of benefiting qi and nourishing blood, the Chinese medicine composition regulating metabolism and preparation thereof and method for making.
Background technology
Metabolism syndrome refers to the pathological state of the material generation metabolism disorders such as the protein of human body, fat, carbohydrate, represent the main health problem in all of industrialized country, diagnosis accounts for the 20%-40% of person in middle and old age's population for this syndrome patients, the prevalence of northern China resident is higher than south, respectively 23.3% and 11.5%, urbanite is higher than urban residents, and respectively 23.5% and 14.7%.Metabolism syndrome is a complex set of metabolism disorder disease group, it it is the risk factor of heart disease, diabetes and cardiovascular and cerebrovascular disease causing occurring together, these risk factor mainly include metabolism obstacles of blood glucose (impaired fasting glucose (IFG), impaired glucose tolerance, type Ⅱdiabetes mellitus), Anomalous lipid metablism (blood triglyceride concentration raises, Very Low Density Lipoprotein Concentration raises, High-density Lipoprotein-cholesterol reduces), hypertension, central obesity etc..Owing to metabolism syndrome shows symptom variation, Common drugs treatment for one of which symptom treatment, such as control blood glucose, hypertension and hyperlipemia, control body weight, can only alleviate insulin resistant etc., the medicine of rare Comprehensive Treatment.
Summary of the invention
It is a feature of the present invention that offer is a kind of safely and effectively, formula is reasonable, can have benefiting qi and nourishing blood, regulate the composition and method of making the same of metabolism.
For achieving the above object, the concrete technical scheme of the present invention is as follows:
A kind of benefiting qi and nourishing blood, regulate metabolism Chinese medicine composition, be mainly prepared from by the raw material of following parts by weight is processed: Cortex Illicii 12-20, Cordyceps militaris 1-4, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-12, RADIX CURCUMAE 5-10, Flos Matricariae chamomillae 8-20, black Fructus Mori 10-20, Fructus Lycii 8-16, Fructus Schisandrae Chinensis 15-25, Fructus Cannabis 5-15, Herba Pogostemonis 5-15, Poria 8-16, Pericarpium Citri Reticulatae 5-15, Semen Persicae 5-15.
The Chinese medicine composition total tune body function that this provides, QI and blood is double; two to be adjusted, reinforcement and elimination in combination, by regulating QI, invigorate blood circulation, dredging collateral, the inside and outside microchannel of dredging and body discharges system, remove virus and immune complex in time, thus reaching the effect of vital QI recovered after pathogens eliminated, the work of controlled atmosphere blood, adjustment metabolism, reduce blood glucose, blood fat, control body weight and increase, regulate the effect such as insulin and intestinal microbial population substantially, treatment metabolism syndrome is had good effect.
Further, prepare described compositions and also include the raw material of following weight portion: Colla Corii Asini 5-15, Radix Bupleuri 8-18, Herba Portulacae 8-20, Flos Chrysanthemi 5-20.
Optimizing described composite formula, in conjunction with theory of Chinese medical science, in addition make each component synergism after above-mentioned raw materials, further enhance curative effect, especially at regulating intestinal canal flora, improve body discharges system and reduce body weight aspect, effect is more preferably.
Further, prepare described compositions and also include the raw material of following weight portion: Semen Cassiae 15-25, Spora Lygodii 12-20, Semen Euryales 12-20, Cortex Cinnamomi 10-20.
Optimize described composite formula, after increasing above-mentioned raw materials, synergism further with each component, further enhance curative effect, especially regulating blood pressure, blood glucose and lipid aspects, also can treat three-hypers disease.
Preferably, preparing the raw materials used parts by weight of described compositions is: Colla Corii Asini 10, Cordyceps militaris 3, Hericium erinaceus (Bull. Ex Fr.) Pers. 10, Herba Portulacae 15, Flos Matricariae chamomillae 15, black Fructus Mori 13, Fructus Lycii 14, Flos Chrysanthemi 15, Fructus Cannabis 10, Semen Cassiae 21, Semen Euryales 15, Radix Bupleuri 12, Herba Pogostemonis 10, Poria 12, Pericarpium Citri Reticulatae 8, Semen Persicae 8, Cortex Cinnamomi 14, RADIX CURCUMAE 6, Cortex Illicii 18, Spora Lygodii 15, Fructus Schisandrae Chinensis 20.
On the other hand, the invention provides a kind of benefiting qi and nourishing blood, regulate the Chinese medicine composition of metabolism, prepare described compositions and include the raw material of following weight portion: Cordyceps militaris 1-4, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-12, Flos Matricariae chamomillae 8-20, black Fructus Mori 10-20, Fructus Lycii 8-16, Fructus Cannabis 5-15, Herba Pogostemonis 5-15, Poria 8-16, Pericarpium Citri Reticulatae 5-15, Semen Persicae 5-15, Colla Corii Asini 5-15, Herba Portulacae 8-20, Flos Chrysanthemi 5-20, Semen Cassiae 15-25, Semen Euryales 12-20, Cortex Cinnamomi 10-20.
In order to improve ease of use, the oral formulations that described benefiting qi and nourishing blood, the Chinese medicine composition regulating metabolism and pharmaceutically acceptable adjuvant are made by the present invention, described preparation is pill, tablet, capsule, powder or granule；Described benefiting qi and nourishing blood, the Chinese medicine composition regulating metabolism and adjuvant ratio of weight and number are 1:1-2.
Preferably, described oral formulations is tablet, and it is the diluent of 3-4:1-2:0.8-1.2, disintegrating agent and binding agent that described adjuvant includes ratio of weight and number.
Wherein, the mixture of the imidazolidine urea of described diluent to be ratio of weight and number be 3:1 and N-dodecyl amine xyloside；Described disintegrating agent is ratio of weight and number is the mixture of the glyceryl monostearate of 2:1 and propyl hydroxybenzoate；Described binding agent is ratio of weight and number is the mixture of the chitose of 5:3 and orange peel oil.
Above-mentioned adjuvant selected by the present invention, with the active component in each component and Chinese medicine extract without effect, three kinds of accessory formulas are reasonable, wherein diluent not only plays dilution and the effect filled, the characteristic of good mobility can also be taken into account, making constituent content uniform, drug dose is controlled, and active component plays stable effect simultaneously；Use the mixed adhesive of above-mentioned consumption, the bonding that capsule powder is good can be made, it is ensured that capsule quality；Use above-mentioned consumption mixing disintegrating agent to match with other adjuvants, it is ensured that the disintegrate effectiveness of capsule, make the active component of compositions can reach maximum absorption with the fastest speed.
Further, described adjuvant also includes ratio of weight and number is the Vicryl Rapide of 3:2:0.7, guar gum and sodium chloride mixture.
After increasing above-mentioned adjuvant, medicine and adjuvant are made microcapsule, then capsule is made, the microcapsule capsule material that three kinds of adjuvant mixture are formed, with medicine without effect and release medicine speed well, further improve medicine stability and dissolubility, make medicine be absorbed by the body to greatest extent, and then improve the bioavailability of capsule；And adjuvant safety selected by the present invention is high, internal absorbing, biodegradable, stability is high.
The invention provides described benefiting qi and nourishing blood, the preparation method regulating the Chinese medicine composition of metabolism further, the method comprises the steps:
1) take the Flos Matricariae chamomillae of formula ratio, black Fructus Mori, Herba Pogostemonis, Poria, Fructus Cannabis, Hericium erinaceus (Bull. Ex Fr.) Pers. and Semen Euryales and pulverize as fine powder, by the mixed solution reflux, extract, three times of the methanol that volume ratio is 1:5 and ethyl acetate, add the mixed solution reflux, extract, 2-4h of raw material gross weight 3-5 times every time, after united extraction liquid, concentrating under reduced pressure, obtains extractum stand-by；
2) Herba Portulacae of formula ratio, Fructus Lycii, Semen Cassiae, Flos Chrysanthemi, Pericarpium Citri Reticulatae and Cortex Cinnamomi are taken, by the ethanol water reflux, extract, three times of 30%-50%, add the alcohol reflux 2-3h of raw material gross weight 3-5 times, after united extraction liquid every time, concentrating under reduced pressure, obtains extractum stand-by；
3) take Colla Corii Asini, Cordyceps militaris and Semen Persicae clean dry, the fine powder after pulverizing is stand-by；
4) by step 1) and step 2) extractum and the step 3 that obtain) fine powder that obtains mixs homogeneously, and obtains described compositions.
Preferred preparation method of the present invention, is through lot of experiments, reasonably plans as a whole and contrast is summed up and gone out, extract comprehensively and remain the effective ingredient of medicine, it is ensured that the reasonability of medicine and high efficiency.
It addition, the present invention also provides for the purposes of described compositions and preparation thereof, it is used for the application treating in the medicine of deficiency of qi and blood and/or Metabolic disorder in preparation.
Benefiting qi and nourishing blood of the present invention, regulate the Chinese medicine composition of metabolism in conjunction with theory of Chinese medical science, analyze raw material of Chinese medicine effective ingredient, be aided with the optimization of clinical application for many years simultaneously, the problem overcoming taboo combination, health is had no side effect；Total tune body function, QI and blood is double; two to be adjusted, reinforcement and elimination in combination, by regulating QI, invigorate blood circulation, dredging collateral, the inside and outside microchannel of dredging and body discharges system, remove virus and immune complex in time, thus reach vital QI recovered after pathogens eliminated, controlled atmosphere blood is lived, regulate the effect of metabolism, reduces blood glucose, blood fat, control body weight and increase, regulate the effect such as insulin and intestinal microbial population substantially, treatment metabolism syndrome is had good effect, and anti-smelting disease and healthy effect are notable.
Detailed description of the invention
Embodiment 1
A kind of benefiting qi and nourishing blood, regulate metabolism Chinese medicine composition, said composition is prepared from by the raw material of following parts by weight is processed: Cortex Illicii 15, Cordyceps militaris 2, Hericium erinaceus (Bull. Ex Fr.) Pers. 8, RADIX CURCUMAE 7, Flos Matricariae chamomillae 13, black Fructus Mori 15, Fructus Lycii 10, Fructus Schisandrae Chinensis 20, Fructus Cannabis 10, Herba Pogostemonis 8, Poria 15, Pericarpium Citri Reticulatae 10, Semen Persicae 9.
Embodiment 2
A kind of benefiting qi and nourishing blood, regulate metabolism Chinese medicine composition, said composition is prepared from by the raw material of following parts by weight is processed: Cortex Illicii 18, Cordyceps militaris 3, Hericium erinaceus (Bull. Ex Fr.) Pers. 7, RADIX CURCUMAE 8, Flos Matricariae chamomillae 15, black Fructus Mori 15, Fructus Lycii 15, Fructus Schisandrae Chinensis 20, Fructus Cannabis 14, Herba Pogostemonis 6, Poria 12, Pericarpium Citri Reticulatae 10, Semen Persicae 12, Colla Corii Asini 10, Radix Bupleuri 15, Herba Portulacae 15, Flos Chrysanthemi 15.
Embodiment 3
A kind of benefiting qi and nourishing blood, regulate metabolism Chinese medicine composition, said composition is prepared from by the raw material of following parts by weight is processed: Colla Corii Asini 10, Cordyceps militaris 3, Hericium erinaceus (Bull. Ex Fr.) Pers. 10, Herba Portulacae 15, Flos Matricariae chamomillae 15, black Fructus Mori 13, Fructus Lycii 14, Flos Chrysanthemi 15, Fructus Cannabis 10, Semen Cassiae 21, Semen Euryales 15, Radix Bupleuri 12, Herba Pogostemonis 10, Poria 12, Pericarpium Citri Reticulatae 8, Semen Persicae 8, Cortex Cinnamomi 14, RADIX CURCUMAE 6, Cortex Illicii 18, Spora Lygodii 15, Fructus Schisandrae Chinensis 20.
Embodiment 4
A kind of benefiting qi and nourishing blood, regulate metabolism Chinese medicine composition, said composition is prepared from by the raw material of following parts by weight is processed: Cortex Illicii 20, Cordyceps militaris 4, Hericium erinaceus (Bull. Ex Fr.) Pers. 12, RADIX CURCUMAE 10, Flos Matricariae chamomillae 20, black Fructus Mori 20, Fructus Lycii 16, Fructus Schisandrae Chinensis 25, Fructus Cannabis 15, Herba Pogostemonis 15, Poria 16, Pericarpium Citri Reticulatae 15, Semen Persicae 15, Colla Corii Asini 15, Radix Bupleuri 18, Herba Portulacae 20, Flos Chrysanthemi 20, Semen Cassiae 25, Spora Lygodii 20, Semen Euryales 20, Cortex Cinnamomi 20.
Embodiment 5
A kind of benefiting qi and nourishing blood, regulate metabolism Chinese medicine composition, said composition is prepared from by the raw material of following parts by weight is processed: Cordyceps militaris 1, Hericium erinaceus (Bull. Ex Fr.) Pers. 5, Flos Matricariae chamomillae 10, black Fructus Mori 10, Fructus Lycii 10, Fructus Cannabis 5, Herba Pogostemonis 5, Poria 16, Pericarpium Citri Reticulatae 15, Semen Persicae 15, Colla Corii Asini 10, Herba Portulacae 20, Flos Chrysanthemi 5, Semen Cassiae 15, Semen Euryales 12, Cortex Cinnamomi 10.
Embodiment 6
A kind of benefiting qi and nourishing blood, regulate metabolism Chinese medicine composition, said composition is prepared from by the raw material of following parts by weight is processed: Cortex Illicii 12, Cordyceps militaris 1, Hericium erinaceus (Bull. Ex Fr.) Pers. 5, RADIX CURCUMAE 5, Flos Matricariae chamomillae 8, black Fructus Mori 10, Fructus Lycii 8, Fructus Schisandrae Chinensis 15, Fructus Cannabis 5, Herba Pogostemonis 5, Poria 8, Pericarpium Citri Reticulatae 5, Semen Persicae 5.
Preparation method:
1) take the Flos Matricariae chamomillae of formula ratio, black Fructus Mori, Herba Pogostemonis, Poria, Fructus Cannabis, Hericium erinaceus (Bull. Ex Fr.) Pers. and Fructus Schisandrae Chinensis and pulverize as fine powder, by the mixed solution reflux, extract, three times of the methanol that volume ratio is 1:5 and ethyl acetate, add the mixed solution reflux, extract, 2h of raw material gross weight 5 times every time, after united extraction liquid, concentrating under reduced pressure, obtains extractum stand-by；
2) Fructus Lycii of formula ratio, Pericarpium Citri Reticulatae, RADIX CURCUMAE and Cortex Illicii are taken, the ethanol water reflux, extract, with 50% three times, add the alcohol reflux 3h of raw material gross weight 3 times every time, after united extraction liquid, concentrating under reduced pressure, obtain extractum stand-by；
3) taking Cordyceps militaris and Semen Persicae is cleaned and dried, the fine powder after pulverizing is stand-by；
4) by step 1) and step 2) extractum and the step 3 that obtain) fine powder that obtains mixs homogeneously, and obtains described compositions.
Embodiment 7
A kind of benefiting qi and nourishing blood, regulate metabolism Chinese medicine composition, said composition is prepared from by the raw material of following parts by weight is processed: Cortex Illicii 20, Cordyceps militaris 4, Hericium erinaceus (Bull. Ex Fr.) Pers. 12, RADIX CURCUMAE 10, Flos Matricariae chamomillae 20, black Fructus Mori 20, Fructus Lycii 16, Fructus Schisandrae Chinensis 25, Fructus Cannabis 15, Herba Pogostemonis 15, Poria 16, Pericarpium Citri Reticulatae 15, Semen Persicae 15, Colla Corii Asini 15, Radix Bupleuri 18, Herba Portulacae 20, Flos Chrysanthemi 20.
Preparation method:
1) take the Flos Matricariae chamomillae of formula ratio, black Fructus Mori, Herba Pogostemonis, Poria, Fructus Cannabis, Hericium erinaceus (Bull. Ex Fr.) Pers., Fructus Schisandrae Chinensis and Flos Chrysanthemi and pulverize as fine powder, by the mixed solution reflux, extract, three times of the methanol that volume ratio is 1:5 and ethyl acetate, add the mixed solution reflux, extract, 4h of raw material gross weight 3 times every time, after united extraction liquid, concentrating under reduced pressure, obtains extractum stand-by；
2) Radix Bupleuri of formula ratio, Fructus Lycii, Herba portulacae, Pericarpium Citri Reticulatae, RADIX CURCUMAE and Cortex Illicii are taken, ethanol water reflux, extract, with 30% three times, adds the alcohol reflux 2h of raw material gross weight 5 times, after united extraction liquid every time, concentrating under reduced pressure, obtains extractum stand-by；
3) take Colla Corii Asini, Cordyceps militaris and Semen Persicae clean dry, the fine powder after pulverizing is stand-by；
4) by step 1) and step 2) extractum and the step 3 that obtain) fine powder that obtains mixs homogeneously, and obtains described compositions.
Embodiment 8
A kind of benefiting qi and nourishing blood, regulate metabolism Chinese medicine composition, be prepared from by the raw material of following weight portion is processed: Cortex Illicii 12, Cordyceps militaris 1, Hericium erinaceus (Bull. Ex Fr.) Pers. 5, RADIX CURCUMAE 5, Flos Matricariae chamomillae 8, black Fructus Mori 10, Fructus Lycii 8, Fructus Schisandrae Chinensis 15, Fructus Cannabis 5, Herba Pogostemonis 5, Poria 8, Pericarpium Citri Reticulatae 5, Semen Persicae 5, Colla Corii Asini 5, Radix Bupleuri 8, Herba Portulacae 8, Flos Chrysanthemi 5, Semen Cassiae 15, Spora Lygodii 12, Semen Euryales 12, Cortex Cinnamomi 10.
Preparation method:
1) take the Flos Matricariae chamomillae of formula ratio, black Fructus Mori, Herba Pogostemonis, Poria, Fructus Cannabis, Cortex Cinnamomi, Hericium erinaceus (Bull. Ex Fr.) Pers., Fructus Schisandrae Chinensis and Flos Chrysanthemi and pulverize as fine powder, by the mixed solution reflux, extract, three times of the methanol that volume ratio is 1:5 and ethyl acetate, add the mixed solution reflux, extract, 3h of raw material gross weight 4 times every time, after united extraction liquid, concentrating under reduced pressure, obtains extractum stand-by；
2) Radix Bupleuri of formula ratio, Fructus Lycii, Herba portulacae, Semen Cassiae, Semen Euryales, Pericarpium Citri Reticulatae, RADIX CURCUMAE and Cortex Illicii are taken, ethanol water reflux, extract, with 45% three times, adds the alcohol reflux 2.5h of raw material gross weight 4 times, after united extraction liquid every time, concentrating under reduced pressure, obtains extractum stand-by；
3) take Colla Corii Asini, Cordyceps militaris, Spora Lygodii and Semen Persicae clean dry, the fine powder after pulverizing is stand-by；
4) by step 1) and step 2) extractum and the step 3 that obtain) fine powder that obtains mixs homogeneously, and obtains described compositions.
Embodiment 9 capsule
Compositions 10g prepared by embodiment 1
Adjuvant: imidazolidine urea 4.69g
N-dodecyl amine xyloside 1.56g
Glyceryl monostearate 1.39g
Propyl hydroxybenzoate 0.69g
Chitose 1.044g
Orange peel oil 0.626g
Preparation method:
1) lactose and N-dodecyl amine xyloside are joined in 50% ethanol that weight adds 2 times amount, it is fully ground to pastel, the mixture of the compositions prepared by embodiment 1, glyceryl monostearate, propyl hydroxybenzoate, chitose and orange peel oil is joined in pastel, granulates after mix homogeneously and dry；
2) by step 1) pellet through sieves that obtains, load in capsule shells after granulate metering, obtain described capsule.
Embodiment 10 capsule
Compositions 10g prepared by embodiment 2
Adjuvant: imidazolidine urea 3.91g
N-dodecyl amine xyloside 1.30g
Glyceryl monostearate 2.778g
Propyl hydroxybenzoate 1.389g
Chitose 1.56g
Orange peel oil 0.94g
Vicryl Rapide 1.578g
Guar gum 1.053g
Sodium chloride 0.368g
Preparation method:
1) Vicryl Rapide is joined in the water of weight 30 times, add guar gum and sodium chloride, mix homogeneously obtains aqueous phase, by glyceryl monostearate, propyl hydroxybenzoate, 1/2 imidazolidine urea, 1/2N-dodecyl amine xyloside, chitose, compositions prepared by orange peel oil and embodiment 2 be dissolved in 95% ethanol of gross weight 5 times, form oil phase；Oil phase is joined mix homogeneously in aqueous phase, after continuous ultrasound processes 25min, prepares colostrum；It is placed in high pressure homogenizer by colostrum emulsifying, prepares emulsion；By emulsion micronizing, prepared particle size range is the pastille microcapsule of 10 μm；
2) by step 1) the pastille microcapsule that obtains mixs homogeneously with remaining imidazolidine urea and N-dodecyl amine xyloside, prepares mixed powder, and load in capsule after measuring, obtain described capsule.
Embodiment 11 capsule
Compositions 10g prepared by embodiment 3
Adjuvant: starch 8.75g
N-dodecyl amine xyloside 2.92g
Glyceryl monostearate 3.33g
Propyl hydroxybenzoate 1.67g
Chitose 3.334g
Preparation method: be prepared by the method described in embodiment 9.
Test 1 benefiting qi and nourishing blood, regulate the Chinese medicine composition pharmacological activity test to meals obesity-induced mice model of metabolism
1 test material
1.1 test medicine:
Test the compositions that 1 group is embodiment 1 preparation, testing 2 groups is compositions described in embodiment 2, testing 3 groups is compositions described in embodiment 3, testing 4 groups is compositions described in embodiment 5, and matched group is the Chinese medicine composition of the treatment metabolism syndrome disclosed in Chinese patent CN201410620763.6.
1.2 experimental animals:
The C57 mice in 4-5 week, male, experiment condition is ambient temperature 22 DEG C～24 DEG C, humidity 45%-50%, controls optical illumination 12 hours, and dark 12 hours, animal freely ingested and drinks water.
2 test methods
2.1 test methods
Blank group C57 mice feeds with normal diet.Other C57 mices all feed with high lipid food, freely enter to take the photograph water food.When mice was fed to 8 weeks, according to Mouse Weight by mice group, make each group of body weight consistent, often group 10.From the 8th week, animal gavaged equal-volume normal saline by packet to respective reagent, model group and blank group, amounts to 12 weeks.Every 2 weeks of period detection animal is random and fasting glucose and body weight change, every 4 weeks detection animal serum insulin levels, experiment detects the total triglyceride of animal, T-CHOL, low-density lipoprotein cholesterol level with (the 0th week and the 12nd week) when terminating before starting, and take animal fresh excreta, external bacteria group culture detect its to escherichia coli, bacteroid, lactic acid bacteria, bacillus bifidus proliferation function.
2.2 laboratory animal packet design
Take mice and be randomly divided into seven groups, and test 1 group, test 2 groups, test 3 groups, test 4 groups, matched group, blank group (gavaging normal saline) and model group (gavaging normal saline), often group 10, each group test dose is 3g/kg, and every day is according to above-mentioned dosage gavage once.
3 result of the tests
3.1 impacts that meals inducing obesity (DIO) Mouse Weight is increased
The 9:00 in morning Tuesday of every 2 weeks records the weight of animals, and result is table 1 such as.
Table 1 on the impact of DIO Mouse Weight (body weight value, g)
Note: compare P with model groupa<0.01,Pb< 0.05, compare P with matched groupc< 0.01, compare P with testing 1 groupd<0.05。
Above-mentioned result of the test is known, test group and matched group all can increase by suppression Mouse Weight in various degree, and wherein composition effect of the present invention is superior to matched group, wherein test 2 groups with 3 groups of curative effects of test more preferably, considerably beyond matched group, and compared with testing 1 group, there is diversity；Test no significant difference between 2 groups and test 3 groups.
3.2 impacts on DIO mice fasting glucose
Each treated animal takes hematometry random blood sugar in first day 9:00am tail point of every 2 weeks, and fasting subsequently 6 hours, 15:00pm measures fasting glucose, and experimental result is as shown in table 2.
The table 2. impact (blood glucose value, mmol/L) on DIO mice fasting glucose
Note: compare P with model groupa<0.01,Pb< 0.05, compare P with matched groupd<0.01,Pc<0.05。
3.3 impacts on DIO lipid of mice level
Each treated animal in experiment the 0th week and the 12nd week all 4 the morning 9:00 eye socket take blood, after separated plasma mensuration the total triglyceride of blood plasma, T-CHOL, low-density lipoprotein cholesterol level.Result is in Table 3.
The table 3. impact (mM) on DIO mice plasma blood lipid level
Note: compare P with model groupa< 0.01, compare P with matched groupc< 0.05, Pd<0.01。
Above-mentioned result of the test is known, test group all can reduction mouse blood sugar in various degree and blood lipid level, wherein composition effect of the present invention is superior to matched group, wherein tests 3 groups of curative effects more preferably, considerably beyond matched group, and it is respectively provided with diversity compared with testing 1 group, test 2 groups and testing 4 groups；Test 1 group mouse blood sugar and blood fat ability are relatively tested 4 groups more excellent.
3.4 impacts on DIO mice serum insulin level
Every 4 weeks of each treated animal in the morning Wednesday 9:00 eye socket take blood, 4000rpm centrifuging and taking serum, be used for measuring serum insulin levels.Result is in Table 4.
The table 4. impact (insulin, ng/mL) on DIO mice serum insulin level
Note: compare P with model groupa< 0.01, compare P with matched groupc<0.01。
Above-mentioned result of the test is it can be seen that the effect that compositions of the present invention reduces mice serum insulin level is all far superior to matched group, evident in efficacy.
3.5 impacts on DIO mouse intestinal flora metabolism
Each treated animal in the 0th week and the 12nd week morning Tuesday 9:00-12:00 move in metabolic cage, collect fresh excreta, carry out intestinal microbial population detection (including escherichia coli, lactobacillus and bacillus bifidus), result is in Table 5.
The table 5. impact (LogCFU/g) on DIO mouse intestinal flora content
Note: compare P with matched groupa<0.01,Pd<0.05；P is compared with testing 1 groupb< 0.01, Pc<0.05。
Be can be seen that by above-mentioned result of the test, compositions of the present invention can substantially regulate mouse intestinal flora content, and matched group is very micro-to mouse intestinal flora regulating effect, wherein, test 2 groups of effects relatively test 1 group and test 4 groups variant, and test between 2 groups and test 3 groups, the regulating intestinal canal flora weak effect opposite sex is inconspicuous.
4. conclusion
By on for meals obesity-induced mice model test the known benefiting qi and nourishing blood provided by the present invention of result, regulate metabolism Chinese medicine composition, the body weight increase that obesity mice class Metabolic Syndrome Patients shows can be effectively improved, blood pressure and blood lipoid is disorderly, and serum insulin content increases and the symptom such as alteration of intestinal flora；Wherein testing 2 groups on the basis of test 1 group, adjustment effect and reduction Mouse Weight aspect effect for intestinal microbial population are more excellent；And test 3 groups on the test basis of 2 groups, and improve further and reduce lipid of mice hypoglycemic effect, testing 1 group, relatively to test 4 groups of effects more excellent.

Claims (10)

1. a benefiting qi and nourishing blood, regulate the Chinese medicine composition of metabolism, it is characterized in that, described compositions is mainly prepared from by the raw material of following parts by weight is processed: Cortex Illicii 12-20, Cordyceps militaris 1-4, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-12, RADIX CURCUMAE 5-10, Flos Matricariae chamomillae 8-20, black Fructus Mori 10-20, Fructus Lycii 8-16, Fructus Schisandrae Chinensis 15-25, Fructus Cannabis 5-15, Herba Pogostemonis 5-15, Poria 8-16, Pericarpium Citri Reticulatae 5-15, Semen Persicae 5-15.
2. the Chinese medicine composition of benefiting qi and nourishing blood as claimed in claim 1, adjustment metabolism, it is characterised in that prepare described compositions and also include the raw material of following weight portion: Colla Corii Asini 5-15, Radix Bupleuri 8-18, Herba Portulacae 8-20, Flos Chrysanthemi 5-20.
3. the Chinese medicine composition of benefiting qi and nourishing blood as claimed in claim 2, adjustment metabolism, it is characterised in that prepare described compositions and also include the raw material of following weight portion: Semen Cassiae 15-25, Spora Lygodii 12-20, Semen Euryales 12-20, Cortex Cinnamomi 10-20.
4. the Chinese medicine composition of benefiting qi and nourishing blood as claimed in claim 3, adjustment metabolism, it is characterized in that, the parts by weight preparing described composition material are: Colla Corii Asini 10, Cordyceps militaris 3, Hericium erinaceus (Bull. Ex Fr.) Pers. 10, Herba Portulacae 15, Flos Matricariae chamomillae 15, black Fructus Mori 13, Fructus Lycii 14, Flos Chrysanthemi 15, Fructus Cannabis 10, Semen Cassiae 21, Semen Euryales 15, Radix Bupleuri 12, Herba Pogostemonis 10, Poria 12, Pericarpium Citri Reticulatae 8, Semen Persicae 8, Cortex Cinnamomi 14, RADIX CURCUMAE 6, Cortex Illicii 18, Spora Lygodii 15, Fructus Schisandrae Chinensis 20.
5. a benefiting qi and nourishing blood, regulate the Chinese medicine composition of metabolism, it is characterized in that, prepare described compositions and include the raw material of following weight portion: Cordyceps militaris 1-4, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-12, Flos Matricariae chamomillae 8-20, black Fructus Mori 10-20, Fructus Lycii 8-16, Fructus Cannabis 5-15, Herba Pogostemonis 5-15, Poria 8-16, Pericarpium Citri Reticulatae 5-15, Semen Persicae 5-15, Colla Corii Asini 5-15, Herba Portulacae 8-20, Flos Chrysanthemi 5-20, Semen Cassiae 15-25, Semen Euryales 12-20, Cortex Cinnamomi 10-20.
6. benefiting qi and nourishing blood as described in as arbitrary in claim 1-5, regulate the oral formulations that the Chinese medicine composition of metabolism is made with pharmaceutically acceptable adjuvant, it is characterised in that described preparation is pill, tablet, capsule, powder or granule；Described benefiting qi and nourishing blood, the Chinese medicine composition regulating metabolism and adjuvant ratio of weight and number are 1:1-2.
7. oral formulations as claimed in claim 6, it is characterized in that, described preparation is capsule, it is the diluent of 3-4:1-2:0.8-1.2, disintegrating agent and binding agent that described adjuvant includes ratio of weight and number, and described diluent is ratio of weight and number is the mixture of the imidazolidine urea of 3:1 and N-dodecyl amine xyloside；Described disintegrating agent is ratio of weight and number is the mixture of the glyceryl monostearate of 2:1 and propyl hydroxybenzoate；Described binding agent is ratio of weight and number is the mixture of the chitose of 5:3 and orange peel oil.
8. oral formulations as claimed in claim 7, it is characterised in that it is the Vicryl Rapide of 3:2:0.7, guar gum and sodium chloride mixture that described adjuvant also includes ratio of weight and number.
9. a benefiting qi and nourishing blood as claimed in claim 1, the preparation method that regulates the Chinese medicine composition of metabolism, it is characterised in that described preparation method comprises the steps:
1) take the Flos Matricariae chamomillae of formula ratio, black Fructus Mori, Herba Pogostemonis, Poria, Fructus Cannabis, Hericium erinaceus (Bull. Ex Fr.) Pers. and Fructus Schisandrae Chinensis and pulverize as fine powder, by the mixed solution reflux, extract, three times of the methanol that volume ratio is 1:5 and ethyl acetate, add the mixed solution reflux, extract, 2-4h of raw material gross weight 3-5 times every time, after united extraction liquid, concentrating under reduced pressure, obtains extractum stand-by；
2) take the Fructus Lycii of formula ratio, Pericarpium Citri Reticulatae, RADIX CURCUMAE and Cortex Illicii, by the ethanol water reflux, extract, three times of 30%-50%, add the alcohol reflux 2-3h of raw material gross weight 3-5 times every time, after united extraction liquid, concentrating under reduced pressure, obtain extractum stand-by；
3) taking Cordyceps militaris and Semen Persicae is cleaned and dried, the fine powder after pulverizing is stand-by；
4) by step 1) and step 2) extractum and the step 3 that obtain) fine powder that obtains mixs homogeneously, and obtains described compositions.
10. the compositions as described in as arbitrary in claim 1-5 in preparation for treating the application in the medicine of deficiency of qi and blood and/or Metabolic disorder.
CN201610218053.XA 2016-04-08 2016-04-08 Traditional Chinese medicine composition for benefiting qi, nourishing blood and adjusting metabolism and preparation and preparation method thereof Pending CN105770741A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1799620A (en) * 2005-08-17 2006-07-12 王林祥 Healthcare wine and its preparation method
CN105381333A (en) * 2015-12-15 2016-03-09 赵金 Traditional Chinese medicine composition with effects of treating spleen-kidney Yang deficiency

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1799620A (en) * 2005-08-17 2006-07-12 王林祥 Healthcare wine and its preparation method
CN105381333A (en) * 2015-12-15 2016-03-09 赵金 Traditional Chinese medicine composition with effects of treating spleen-kidney Yang deficiency

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
梁振荣: "柴术桃附汤治疗高脂血症60例", 《现代中医药》 *
裴宏彬: "滋补肝肾法治疗早期糖尿病肾病55例", 《辽宁中医杂志》 *

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Application publication date: 20160720