CN105770542A - Compound preparation for treating diarrhea - Google Patents
Compound preparation for treating diarrhea Download PDFInfo
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- CN105770542A CN105770542A CN201610221849.0A CN201610221849A CN105770542A CN 105770542 A CN105770542 A CN 105770542A CN 201610221849 A CN201610221849 A CN 201610221849A CN 105770542 A CN105770542 A CN 105770542A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Alternative & Traditional Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention provides a compound preparation for treating diarrhea. The compound preparation is mainly prepared from, by weight, 0.1 part of berberine hydrochloride, 10-20 parts of a water-soluble carrier material, 10-30 parts of rhizoma imperatae, 15-25 parts of fructus evodiae, 5-15 parts of cortex cinnamomi, 15-35 parts of radix aucklandiae, 5-35 parts of fructus rosae laevigatae and 80-120 parts of a framework material. Compared with the prior art, the compound preparation for treating the diarrhea is free of toxic and side effects, comprehensive in treatment effect, capable of effectively treating the diarrhea and significant in effect, achieves one-time use of multiple drugs and has a certain development value.
Description
Technical field
The present invention relates to a kind of compound preparation treating diarrhoea, belong to technical field of traditional Chinese medicine preparation.
Background technology
Diarrhoea is a kind of common sympton, refer to defecation frequency significantly more than the frequency being on ordinary days accustomed to, excrement matter is thin, and moisture increases
Adding, every day, feces volume was more than 200g, or containing not digesting food or pus and blood, mucus.Diarrhoea is often accompanied by defecation urgency sense, anus
The symptoms such as door discomfort, incontinence.Acute and chronic two classes of diarrhoea point.Acute diarrhea fall ill drastically, the course of disease 2～3 weeks it
In.Chronic diarrhea refers to the recurrent diarrhoea that the course of disease is more than two months or the intermission is in 2～4 weeks.This disease onset is anxious,
Can be occurred together heat, stomachache.Pathological changes is positioned at rectum and (or) Sigmoidocolic patient has tenesmus more, and each feces volume is few,
The most only discharging a small amount of gas and mucus, pink colour is relatively deep, how to freeze shape in glutinous, can mixed-blood liquid.The diarrhoea of small intestinal pathological changes is without inner
Weight after urgency, feces is shapeless, can become aqueous, and color is thin, measures more.Chronic pancreatitis and intestinal malabsorption person, excrement
Just visible oil droplet in, many foams, containing food debris, foul smelling.The caused diarrhoea of vibrio cholera is in water from washing rice water sample.Schistosomicide
The diarrhoea that the disease such as disease, chronic dysentery, rectal cancer, ulcerative colitis causes, feces normal band pus and blood.
Therefore, at present for the treatment of diarrhoea, generally require multi-medicament with the use of, not only curative effect is difficult to many-sided holding concurrently
Turn round and look at, and patient adaptability is poor.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the present invention provides a kind of compound preparation treating diarrhoea.
Technical scheme: for achieving the above object, the invention provides a kind of compound preparation treating diarrhoea, and it is mainly by such as
Made by the crude drug of lower weight portion:
Berberine hydrochloride 0.1 part, water soluble carrier material 10-20 part, Rhizoma Imperatae 10-30 part, Fructus Evodiae 15-25 part,
Cortex Cinnamomi 5-15 part, Radix Aucklandiae 15-35 part, Fructus Rosae Laevigatae 5-35 part, framework material 80-120 part.
As preferably, the compound preparation of described treatment diarrhoea is mainly by made by the crude drug of following weight portion:
Berberine hydrochloride 0.1 part, water soluble carrier material 12-18 part, Rhizoma Imperatae 15-25 part, Fructus Evodiae 18-22 part,
Cortex Cinnamomi 8-12 part, Radix Aucklandiae 20-30 part, Fructus Rosae Laevigatae 10-30 part, framework material 90-110 part.
Preferred as another kind, the compound preparation of described treatment diarrhoea is mainly made by the crude drug of following weight portion
Become:
Berberine hydrochloride 0.1 part, water soluble carrier material 10 parts, Rhizoma Imperatae 10 parts, Fructus Evodiae 15 parts,
Cortex Cinnamomi 5 parts, the Radix Aucklandiae 15 parts, Fructus Rosae Laevigatae 5 parts, framework material 80 parts.
Preferred as another kind, the compound preparation of described treatment diarrhoea is mainly made by the crude drug of following weight portion
Become:
Berberine hydrochloride 0.1 part, water soluble carrier material 20 parts, Rhizoma Imperatae 30 parts, Fructus Evodiae 25 parts,
Cortex Cinnamomi 15 parts, the Radix Aucklandiae 35 parts, Fructus Rosae Laevigatae 35 parts, framework material 120 parts.
Preferred as another kind, described water soluble carrier material is Macrogol 4000, polyvidone, polyoxyethylene, poly-carboxylic
Acid ethylene or citric acid.
Preferred as another kind, described framework material is chitosan, sodium carboxymethyl cellulose, ethyl cellulose, hydroxypropyl first
Cellulose or polylactic acid.
Preferred as another kind, described diarrhoea is chronic diarrhea.
Described compound preparation is by made by following steps:
(1) water-soluble carrier material dissolves, and obtains carrier solution, standby；
(2) weigh Rhizoma Imperatae, Fructus Evodiae, Cortex Cinnamomi, the Radix Aucklandiae and Fructus Rosae Laevigatae in proportion, add ethanol extraction, obtain alcohol extraction
Residue and extracting solution, extracting solution concentrates, obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extraction residue, add Aqua pure extract, extracting solution concentrates, and obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and berberine hydrochloride are mixed, high speed dispersion, concentrate, be dried, score
Dissipate thing；
(5) framework material is dissolved, add above-mentioned alcohol extract, high speed dispersion, concentrate, be dried, obtain synthetic；
(6) by above-mentioned dispersion and synthetic mix homogeneously, to obtain final product.
As preferably:
Described in step (2), ethanol extraction is: the 60-80% alcohol reflux of 6-10 times of volume of addition 2 times, every time
2 hours.
Described in step (3), Aqua pure extract is: the water reflux, extract, of 8-12 times of volume of addition 2 times, each 2 hours.
Described in step (4) or (5), the condition of high speed dispersion is: 5000-7000r/min, disperses 30-60 minute.
Beneficial effect: relative to prior art, the compound preparation of gained of the present invention treatment diarrhoea, have no side effect, curative effect
Comprehensively, it is possible to effectively treat diarrhoea, and achieving the disposable medication of multi-medicament, effect is notable, has certain
Development volue.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1
Prescription:
Berberine hydrochloride 0.1 part, Macrogol 4000 10 parts, Rhizoma Imperatae 10 parts, Fructus Evodiae 15 parts,
Cortex Cinnamomi 5 parts, the Radix Aucklandiae 15 parts, Fructus Rosae Laevigatae 5 parts, chitosan 80 parts.
Preparation technology:
(1) taking polyethylene glycol 4000 dissolves, and obtains carrier solution, standby；
(2) weigh Rhizoma Imperatae, Fructus Evodiae, Cortex Cinnamomi, the Radix Aucklandiae and Fructus Rosae Laevigatae in proportion, add 80% second of 6 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extraction residue and extracting solution, and extracting solution concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extraction residue, the water reflux, extract, of 8 times of volumes of addition 2 times, each 2 hours, extracting solution was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and berberine hydrochloride are mixed, 5000r/min, high speed dispersion 60 minutes,
Concentrate, be dried, obtain dispersion；
(5) chitosan is dissolved, adds above-mentioned alcohol extract, 5000r/min, high speed dispersion 60 minutes, concentrate, be dried,
Obtain synthetic；
(6) by above-mentioned dispersion and synthetic mix homogeneously, to obtain final product.
Embodiment 2
Prescription:
Berberine hydrochloride 0.1 part, polyvidone 20 parts, Rhizoma Imperatae 30 parts, Fructus Evodiae 25 parts,
Cortex Cinnamomi 15 parts, the Radix Aucklandiae 35 parts, Fructus Rosae Laevigatae 35 parts, sodium carboxymethyl cellulose 120 parts.
Preparation technology:
(1) take polyvidone to dissolve, obtain carrier solution, standby；
(2) weigh Rhizoma Imperatae, Fructus Evodiae, Cortex Cinnamomi, the Radix Aucklandiae and Fructus Rosae Laevigatae in proportion, add 60% second of 10 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extraction residue and extracting solution, and extracting solution concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extraction residue, the water reflux, extract, of 12 times of volumes of addition 2 times, each 2 hours, extracting solution was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and berberine hydrochloride are mixed, 7000r/min, high speed dispersion 30 minutes,
Concentrate, be dried, obtain dispersion；
(5) sodium carboxymethyl cellulose is dissolved, add above-mentioned alcohol extract, 7000r/min, high speed dispersion 30 minutes, dense
Contracting, is dried, obtains synthetic；
(6) by above-mentioned dispersion and synthetic mix homogeneously, to obtain final product.
Embodiment 3
Prescription:
Berberine hydrochloride 0.1 part, polyoxyethylene 15 parts, Rhizoma Imperatae 20 parts, Fructus Evodiae 20 parts,
Cortex Cinnamomi 10 parts, the Radix Aucklandiae 25 parts, Fructus Rosae Laevigatae 20 parts, ethyl cellulose 100 parts.
Preparation technology:
(1) take polyoxyethylene to dissolve, obtain carrier solution, standby；
(2) weigh Rhizoma Imperatae, Fructus Evodiae, Cortex Cinnamomi, the Radix Aucklandiae and Fructus Rosae Laevigatae in proportion, add 70% second of 8 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extraction residue and extracting solution, and extracting solution concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extraction residue, the water reflux, extract, of 10 times of volumes of addition 2 times, each 2 hours, extracting solution was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and berberine hydrochloride are mixed, 6000r/min, high speed dispersion 45 minutes,
Concentrate, be dried, obtain dispersion；
(5) ethyl cellulose is dissolved, adds above-mentioned alcohol extract, 6000r/min, high speed dispersion 45 minutes, concentrate,
It is dried, obtains synthetic；
(6) by above-mentioned dispersion and synthetic mix homogeneously, to obtain final product.
Embodiment 4
Prescription:
Berberine hydrochloride 0.1 part, polycarboxylic acids ethylene 12 parts, Rhizoma Imperatae 15 parts, Fructus Evodiae 18 parts,
Cortex Cinnamomi 8 parts, the Radix Aucklandiae 20 parts, Fructus Rosae Laevigatae 10 parts, hypromellose 90 parts.
Preparation technology:
(1) take polycarboxylic acids ethylene dissolution, obtain carrier solution, standby；
(2) weigh Rhizoma Imperatae, Fructus Evodiae, Cortex Cinnamomi, the Radix Aucklandiae and Fructus Rosae Laevigatae in proportion, add 75% second of 7 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extraction residue and extracting solution, and extracting solution concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extraction residue, the water reflux, extract, of 9 times of volumes of addition 2 times, each 2 hours, extracting solution was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and berberine hydrochloride are mixed, 6000r/min, high speed dispersion 40 minutes,
Concentrate, be dried, obtain dispersion；
(5) hypromellose is dissolved, adds above-mentioned alcohol extract, 6000r/min, high speed dispersion 40 minutes, concentrate,
It is dried, obtains synthetic；
(6) by above-mentioned dispersion and synthetic mix homogeneously, to obtain final product.
Embodiment 5
Prescription:
Berberine hydrochloride 0.1 part, citric acid 18 parts, Rhizoma Imperatae 25 parts, Fructus Evodiae 22 parts,
Cortex Cinnamomi 12 parts, the Radix Aucklandiae 30 parts, Fructus Rosae Laevigatae 30 parts, polylactic acid 110 parts.
Preparation technology:
(1) take citric acid to dissolve, obtain carrier solution, standby；
(2) weigh Rhizoma Imperatae, Fructus Evodiae, Cortex Cinnamomi, the Radix Aucklandiae and Fructus Rosae Laevigatae in proportion, add 65% second of 9 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extraction residue and extracting solution, and extracting solution concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extraction residue, the water reflux, extract, of 11 times of volumes of addition 2 times, each 2 hours, extracting solution was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and berberine hydrochloride are mixed, 6000r/min, high speed dispersion 50 minutes,
Concentrate, be dried, obtain dispersion；
(5) polylactic acid is dissolved, adds above-mentioned alcohol extract, 6000r/min, high speed dispersion 50 minutes, concentrate, be dried,
Obtain synthetic；
(6) by above-mentioned dispersion and synthetic mix homogeneously, to obtain final product.
Experimental example compound preparation of the present invention treatment diarrhoea experimentation
Choose 75 laboratory mices (being successfully established Diarrhea Model), be randomly divided into 5 groups, often group 15, respectively
For negative control group, positive controls, embodiment 3-5 group.
Negative control group normal diet；
Positive controls is on the basis of negative control group normal diet, and (consumption is with real to add berberine hydrochloride in feedstuff
Execute example 3,4 and 5 groups), feed；
Embodiment 3,4 and 5 groups, on the basis of negative control group normal diet, gives the embodiment of the present invention 3,4 and
5 products obtained therefroms (wherein berberine hydrochloride consumption is the most identical with positive controls), same incorporation in feedstuff is fed.
All groups are all administered once daily, and successive administration, after 7 days, investigates average weight and the survival rate of each group of mice.
Experimental result see table 1:
Table 1 respectively organize average mice body weight and survival rate (N=15)
Note: compared with negative control group, * P < 0.05；Compared with positive controls, #P < 0.05.
Can be obtained by upper table 1 result, compared with negative control group, positive controls and the embodiment of the present invention 3,4 and 5
Group mice is through treatment, and its average weight and survival rate are significantly increased；Meanwhile, compared with positive controls, the present invention
3,4 and 5 groups of mices of embodiment are after treatment, and its average weight and survival rate are significantly increased, and embodiment 3 groups
Effect is the most notable.
Claims (7)
1. the compound preparation treating diarrhoea, it is characterised in that it is mainly by made by the crude drug of following weight portion:
Berberine hydrochloride 0.1 part, water soluble carrier material 10-20 part, Rhizoma Imperatae 10-30 part, Fructus Evodiae 15-25 part,
Cortex Cinnamomi 5-15 part, Radix Aucklandiae 15-35 part, Fructus Rosae Laevigatae 5-35 part, framework material 80-120 part.
The compound preparation for the treatment of diarrhoea the most according to claim 1, it is characterised in that it is mainly by weighing as follows
Made by the crude drug of amount part:
Berberine hydrochloride 0.1 part, water soluble carrier material 12-18 part, Rhizoma Imperatae 15-25 part, Fructus Evodiae 18-22 part,
Cortex Cinnamomi 8-12 part, Radix Aucklandiae 20-30 part, Fructus Rosae Laevigatae 10-30 part, framework material 90-110 part.
The compound preparation for the treatment of diarrhoea the most according to claim 1, it is characterised in that it is mainly by weighing as follows
Made by the crude drug of amount part:
Berberine hydrochloride 0.1 part, water soluble carrier material 10 parts, Rhizoma Imperatae 10 parts, Fructus Evodiae 15 parts,
Cortex Cinnamomi 5 parts, the Radix Aucklandiae 15 parts, Fructus Rosae Laevigatae 5 parts, framework material 80 parts.
The compound preparation for the treatment of diarrhoea the most according to claim 1, it is characterised in that it is mainly by weighing as follows
Made by the crude drug of amount part:
Berberine hydrochloride 0.1 part, water soluble carrier material 20 parts, Rhizoma Imperatae 30 parts, Fructus Evodiae 25 parts,
Cortex Cinnamomi 15 parts, the Radix Aucklandiae 35 parts, Fructus Rosae Laevigatae 35 parts, framework material 120 parts.
The compound preparation for the treatment of diarrhoea the most according to claim 1, it is characterised in that described water-solubility carrier material
Material is Macrogol 4000, polyvidone, polyoxyethylene, polycarboxylic acids ethylene or citric acid.
The compound preparation for the treatment of diarrhoea the most according to claim 1, it is characterised in that described framework material is shell
Polysaccharide, sodium carboxymethyl cellulose, ethyl cellulose, hypromellose or polylactic acid.
The compound preparation for the treatment of diarrhoea the most according to claim 1, it is characterised in that described diarrhoea is chronic abdomen
Rush down.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610221849.0A CN105770542A (en) | 2016-04-11 | 2016-04-11 | Compound preparation for treating diarrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610221849.0A CN105770542A (en) | 2016-04-11 | 2016-04-11 | Compound preparation for treating diarrhea |
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| Publication Number | Publication Date |
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| CN105770542A true CN105770542A (en) | 2016-07-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610221849.0A Withdrawn CN105770542A (en) | 2016-04-11 | 2016-04-11 | Compound preparation for treating diarrhea |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143173A (en) * | 2007-07-22 | 2008-03-19 | 张家界元尔药业有限公司 | Capsule for treating acute dysentery and acute diarrhea and its preparation method |
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2016
- 2016-04-11 CN CN201610221849.0A patent/CN105770542A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143173A (en) * | 2007-07-22 | 2008-03-19 | 张家界元尔药业有限公司 | Capsule for treating acute dysentery and acute diarrhea and its preparation method |
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Application publication date: 20160720 |