CN105770499A - Method for preparing traditional Chinese medicinal composition for treating senile cutaneous pruritus - Google Patents
Method for preparing traditional Chinese medicinal composition for treating senile cutaneous pruritus Download PDFInfo
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- CN105770499A CN105770499A CN201610302387.5A CN201610302387A CN105770499A CN 105770499 A CN105770499 A CN 105770499A CN 201610302387 A CN201610302387 A CN 201610302387A CN 105770499 A CN105770499 A CN 105770499A
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Abstract
The invention discloses a method for preparing a traditional Chinese medicinal composition for treating senile cutaneous pruritus and belongs to the technical field of traditional Chinese medicine. According to the method, the traditional Chinese medicinal composition is prepared from the following raw materials: rhizoma gastrodiae, fructus kochiae, folium artemisiae argyi, herba menthae, radix saposhnikoviae, radix astragali, radix paeoniae alba, radix rehmanniae preparata, radix scrophulariae, periostracum cicadae, radix angelicae sinensis, cortex moutan, flos lonicerae, herba schizonepetae, mulberry fruit and radix glycyrrhizae. Verified by clinical practice, the traditional Chinese medicinal composition prepared by the method disclosed by the invention has the efficacy of benefiting Qi and nourishing blood, nourishing Yin and moistening dryness, cooling blood and promoting blood circulation and extinguishing breeze flow, and dispelling wind and arresting itching; and aiming at the treatment for the senile cutaneous pruritus, the traditional Chinese medicinal composition has the advantages of quick effects, high pertinence, high cure rate, no relapse and no toxic and side effect.
Description
The application be applicant Linyi Cao Zhimei Pharmaceutical Technology Co., Ltd propose application for a patent for invention (denomination of invention is: a kind of Chinese medicine composition treating senile skin pruritus and preparation method thereof, application number is: 201510653525X, and the applying date is: on October 12nd, 2015) divisional application.
Technical field
The invention belongs to technical field of Chinese medicine, a kind of method being specifically related to Chinese medicine composition preparing treatment senile skin pruritus.
Background technology
Senile skin pruritus is common clinical, frequently-occurring disease.Motherland's medical science belongs to " pruritus caused by wind pathogen ", " pruritus " category.
Mainly due to wind, wet, hot heresy visitor in skin muscular table, cause incoordination between QI and blood in skin and muscle, or due to wind and dryness blocking in skin due to blood-deficiency, skin losing its nutrition forms.Existing as far back as " General Treatise on the Cause and Symptoms of Diseases pruritus caused by wind pathogen time ": " pruritus caused by wind pathogen person, is body void wind-engaging, and wind enters space between skin and muscles, fights mutually with QI and blood, and all comes and goes and be in that between skin.Pathogen is micro-, it is impossible to impact for pain, therefore but pruritus also." generation of this disease is mainly due to aged debility, deficiency of the liver and kindey, essence and blood loses, and skin can not get moistening of essence and blood and supports and cause xerosis cutis, coarse, pruritus, and moist bull is greasy in addition fights between skin space between skin and muscles with ailment said due to cold or exposure mutually, hinders QI-blood circulation, makes pruritus more very.Doctor trained in Western medicine thinks that pruritus is to betide skin and cause a kind of subjective symptoms scratched, and its occurrence cause is more complicated, and general pruritus is divided into endogenous and exogen two kinds.The reason of endogenous pruritus is many with systemic disease such as liver, kidney diaseases, diabetes, malignant tumor, multiple myeloma, and leukemia etc. is relevant, the additionally main cause of endocrine disturbance's morbidity often；Exogen pruritus often and climate change, clothes, Bad Eating Habit, contacts various chemical substance relevant.
Owing to the senile pruritus cause of disease is complicated, very itching unbearably, delay difficulty more, therefore causes old people's misery unbearably.If scratching consumingly continuously, can causing affected part scratch innumerable, bloodstain is in blocks, and sepage is formed a scab, the with the passing of time coarse plumpness of illing skin, pigmentation.If secondary infection, also can causing furuncle, due to intestine erosion and ulcer etc., sickbed patients is also possible to increase the danger of pressure ulcer, has a strong impact on the healthy of old people and quality of life, has largely increased the weight for the treatment of and the burden of nursing.
The treatment of old people's pruritus is a very stubborn problem.Owing to gerontal patient's muscle power and the hypophrenia, compliance decline, and the multiple disease of most of patients depositing, particularly hepatic renal dysfunction, cause that drug administration needs are very careful.The treatment of old people's pruritus, will consider the side effect of the general health situation of human body, the order of severity of symptom, treatment.Finding and remove the key that risk factor is effectively treatment, local treatment is with antipruritic and prevent from infecting for principle.Current external inflammation-resisting itch-stopping medicine such as Mupirocin Ointment, Baolong's health, Eloson etc. clinically, oral antihistamines is clarityne, loratadine etc. such as.Domestic multiple bibliographical information shows that Chinese medicine Senile pruritus has good clinical efficacy and advantage.
Chinese patent application CN201510197051 discloses a kind of Chinese medicine composition treating senile skin pruritus, certain weight ratio is pressed formulated by the Radix Astragali, Concha Ostreae, Radix Angelicae Sinensis, Herba Ophioglossi, Scorpio, Periostracum Cicadae, Citrus leaf, Catechu, Radix Salviae Miltiorrhizae, Caulis Polygoni Multiflori, Radix Arnebiae (Radix Lithospermi), Radix Glycyrrhizae Preparata, Radix Polygoni Multiflori, Cortex Moutan, the Fructus Kochiae, Fructus Xanthii, Radix Sageretiae and Caulis et Folium Arctii, this traditional Chinese medicine composition for treating senile skin pruritus instant effect, do not recur, effective percentage is high, but preparation method is excessively complicated, it is not easy to clinical expansion.
Summary of the invention
For solving the deficiencies in the prior art, a kind of method that the invention provides Chinese medicine composition preparing treatment senile skin pruritus, the Chinese medicine composition flavour of a drug that the method prepares are simplified, easy to use, and instant effect the recurrence after healing can be avoided.
For realizing the purpose of the present invention, inventor is according to the test repeatedly of the research of theory of Chinese medical science and clinic and checking, provide a kind of Chinese medicine composition treating senile skin pruritus, this Chinese medicine composition is prepared from by the raw material of following parts by weight: Rhizoma Gastrodiae 10-20 part, Fructus Kochiae 4-16 part, Folium Artemisiae Argyi 8-18 part, Herba Menthae 4-10 part, Radix Saposhnikoviae 10-18 part, Radix Astragali 6-13 part, Radix Paeoniae Alba 6-14 part, Radix Rehmanniae Preparata 9-16 part, Radix Scrophulariae 8-16 part, Periostracum Cicadae 6-12 part, Radix Angelicae Sinensis 4-12 part, Cortex Moutan 3-10 part, Flos Lonicerae 4-8 part, Herba Schizonepetae 2-7 part, Fructus Mori 5-10 part and Radix Glycyrrhizae 6-16 part.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 10 parts of Rhizoma Gastrodiae, the Fructus Kochiae 4 parts, Folium Artemisiae Argyi 8 parts, Herba Menthae 4 parts, Radix Saposhnikoviae 10 parts, the Radix Astragali 6 parts, the Radix Paeoniae Alba 6 parts, Radix Rehmanniae Preparata 9 parts, Radix Scrophulariae 8 parts, Periostracum Cicadae 6 parts, Radix Angelicae Sinensis 4 parts, Cortex Moutan 3 parts, Flos Lonicerae 4 parts, Herba Schizonepetae 2 parts, Fructus Mori 5 parts and 6 parts of Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 20 parts of Rhizoma Gastrodiae, the Fructus Kochiae 16 parts, Folium Artemisiae Argyi 18 parts, Herba Menthae 10 parts, Radix Saposhnikoviae 18 parts, the Radix Astragali 13 parts, the Radix Paeoniae Alba 14 parts, Radix Rehmanniae Preparata 16 parts, Radix Scrophulariae 16 parts, Periostracum Cicadae 12 parts, Radix Angelicae Sinensis 12 parts, Cortex Moutan 10 parts, Flos Lonicerae 8 parts, Herba Schizonepetae 7 parts, Fructus Mori 10 parts and 16 parts of Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 16 parts of Rhizoma Gastrodiae, the Fructus Kochiae 10 parts, Folium Artemisiae Argyi 12 parts, Herba Menthae 6 parts, Radix Saposhnikoviae 12 parts, the Radix Astragali 8 parts, the Radix Paeoniae Alba 9 parts, Radix Rehmanniae Preparata 15 parts, Radix Scrophulariae 13 parts, Periostracum Cicadae 10 parts, Radix Angelicae Sinensis 8 parts, Cortex Moutan 7 parts, Flos Lonicerae 6 parts, Herba Schizonepetae 4 parts, Fructus Mori 7 parts and 12 parts of Radix Glycyrrhizae.
Utilizing modern general Chinese medicine preparation technology, Chinese medicine composition of the present invention can be made into the finished product preparation of clinical needs, such as dosage forms such as granule, pill, powder, tablet or capsules.
The source of Chinese crude drug, nature and flavor used by Chinese medicine composition of the present invention, return through and effect:
Rhizoma Gastrodiae: the dry tuber of the orchid family Gastrodia plant Rhizoma Gastrodiae；Sweet in the mouth, property is put down, and returns Liver Channel；Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.
The Fructus Kochiae: this product is the dry mature fruit of the chenopod Fructus Kochiae；Acrid in the mouth, hardship, cold in nature；Return kidney, bladder warp；Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort；Acrid in the mouth, hardship；Warm in nature；Return liver,spleen,kidney warp；Dispersing cold for relieving pain, warming the meridian for stopping bleeding.For spitting blood, epistaxis；External treatment skin pruritus.
Herba Menthae: property is pungent, cool, returns lung, Liver Channel；Dispelling wind-heat, refresh oneself, rash；For anemopyretic cold, pathogenic wind-warm is from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.
Radix Saposhnikoviae: this product is the dry root of umbelliferae Saposhnikovia divaricata；Acrid in the mouth, sweet；Warm in nature.Return bladder, liver, spleen channel；Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.For rheumatic arthralgia, rubella pruritus.
The Radix Astragali: for the root of leguminous plant Radix Hedysari multijugi；Sweet in the mouth；Warm in nature；GUIXIN, lung, spleen, kidney channel；Invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing, cure mainly carbuncle difficulty burst or burst do not hold back for a long time.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae；Bitter in the mouth, acid；Cold nature.Return liver, spleen channel；Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating, for limb pain twin, blood deficiency and yellow complexion.
Radix Rehmanniae Preparata: this product is the Preparation process product of Radix Rehmanniae；Sweet in the mouth；Slightly warm in nature.Return liver, kidney channel；Nourishing YIN and supplementing blood, benefit essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, dizziness, tinnitus.
Radix Scrophulariae: this product is the dry root of goatweed Radix Scrophulariae；Sweet in the mouth, hardship, salty；Cold nature.Return lung, stomach, kidney channel；Removing heat from blood YIN nourishing, eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in Tianjin.
Periostracum Cicadae: exuviae shell when this product is the larva emergence of cicada Cryptotympana atrata Fabr.；Sweet in the mouth；Cold in nature；Return lung, Liver Channel；Dissipate wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica；Sweet in the mouth, pungent, warm in nature；Return liver, the heart, spleen channel；Inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Cortex Moutan: this product is the dry root bark of ranunculaceae peony；Bitter in the mouth；Warm in nature；Enter the heart, spleen channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, fall and flutter the pain of injury.
Flos Lonicerae: this product is caprifoliaceae plant Radix Ophiopogonis, Flos Lonicerae, Flos Lonicerae (hair calyx Radix Ophiopogonis) or the dry flower of hair style Radix Ophiopogonis or the first flower opened of band；Sweet in the mouth；Cold in nature.Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae；Acrid in the mouth；Slightly warm in nature.Return lung, Liver Channel.Induce sweat scattered wind, rash.For measles, rubella, skin infection from the beginning of.
Fructus Mori: this product is the fruit ear of moraceae plants Mulberry；Sweet in the mouth, acid；Cold in nature.Liver；Kidney channel.Nourishing YIN and benefiting blood；Promote the production of body fluid；Intestine moistening.Having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence；Soreness of waist tinnitus；Early whitening of beard and hair；Insomnia and dreamful sleep；Tianjin wound is thirsty；Quench one's thirst；Dryness of the intestine constipation.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.；Sweet in the mouth；Property is put down.Gui Jing, GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
The prescription analysis of Chinese medicine of the present invention:
According to the traditional Chinese medical science compatibility theory of dialectical and Chinese crude drug to treatment senile skin pruritus, in conjunction with the feature of the body constitution of modern and modern pharmaceutical technology, the collocation ingredients of reasonable science, form Chinese prescription of the present invention.Prescription of the present invention is with Rhizoma Gastrodiae, the Fructus Kochiae, Folium Artemisiae Argyi, Radix Saposhnikoviae and the Radix Astragali for monarch drug, inducing diaphoresis to dispel wind, invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing；With the Radix Paeoniae Alba, Radix Rehmanniae Preparata and Radix Scrophulariae for ministerial drug, suppressing the hyperactive liver pain relieving, removing heat from blood YIN nourishing, eliminating fire and detoxication；With Periostracum Cicadae, Radix Angelicae Sinensis and Cortex Moutan for adjuvant drug, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling；With Herba Menthae, Flos Lonicerae, Herba Schizonepetae, Fructus Mori and Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain；The all medicines of monarch coordinate, collaborative promotion, complement each other, are finally reached the effects such as inducing diaphoresis to dispel wind, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing, thus senile skin pruritus has very significant therapeutic effect.
The method of a kind of Chinese medicine composition preparing treatment senile skin pruritus of the present invention, comprises the following steps:
(1) weigh Rhizoma Gastrodiae 10-20 part by weight to clean, crushed after being dried, crosses 80-100 mesh sieve, and adding Rhizoma Gastrodiae coarse powder weight 8-12 times amount volume fraction is the ethanol of 60-80%, soak 6-12 hour, supersound extraction twice at 40-60 DEG C of temperature, each 30-50 minute, supersonic frequency was 20-30kHz, filter, merging filtrate, when filtrate reduced in volume is to 60 DEG C, relative density is the clear paste of 1.10-1.20, obtains Rhizoma Gastrodiae extract；
(2) Fructus Kochiae 4-16 part, Folium Artemisiae Argyi 8-18 part, Herba Menthae 4-10 part, Radix Saposhnikoviae 10-18 part, Radix Astragali 6-13 part, Radix Paeoniae Alba 6-14 part, Radix Rehmanniae Preparata 9-16 part, Radix Scrophulariae 8-16 part, Periostracum Cicadae 6-12 part, Radix Angelicae Sinensis 4-12 part, Cortex Moutan 3-10 part, Flos Lonicerae 4-8 part, Herba Schizonepetae 2-7 part, Fructus Mori 5-10 part and Radix Glycyrrhizae 6-16 part are weighed by weight, add the distilled water of above-mentioned total amount 3-5 times of weight of medical material, soak 12-24 hour, decoct 2-4 hour, filter, merging filtrate, concentration, obtaining 60 DEG C of relative densities is the extractum of 1.20-1.25；
(3) extractum that Rhizoma Gastrodiae extract step (1) obtained obtains with step (2) mixes, and dry, pulverize, to obtain final product.
Compared with prior art, present invention have an advantage that
The Chinese medicine composition that the inventive method prepares comes from the achievement in research of China's Chinese medical theory and modern pharmacology, through pharmacodynamic experiment research, clinical practice treatment use, prove its determined curative effect in treatment senile skin pruritus, have no adverse reaction, have the effects such as inducing diaphoresis to dispel wind, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing, dispelling wind for relieving itching, treatment senile skin pruritus instant effect, with strong points, cure rate is high, does not recur, have no side effect, it is easy to popularization and application.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example.Within the scope of the invention or without departing from present disclosure, spirit and scope, change, combination or the replacement that the present invention is carried out, will be apparent to the person skilled in the art, be all contained within the scope of the present invention.
Embodiment l
Embodiment 1 Chinese medicine composition is prepared from by the raw material of following parts by weight:
10 parts of Rhizoma Gastrodiae, the Fructus Kochiae 4 parts, Folium Artemisiae Argyi 8 parts, Herba Menthae 4 parts, Radix Saposhnikoviae 10 parts, the Radix Astragali 6 parts, the Radix Paeoniae Alba 6 parts, Radix Rehmanniae Preparata 9 parts, Radix Scrophulariae 8 parts, Periostracum Cicadae 6 parts, Radix Angelicae Sinensis 4 parts, Cortex Moutan 3 parts, Flos Lonicerae 4 parts, Herba Schizonepetae 2 parts, Fructus Mori 5 parts and 6 parts of Radix Glycyrrhizae.
Preparation method:
(1) take Rhizoma Gastrodiae to clean, crushed after being dried, crosses 80 mesh sieves, and adding Rhizoma Gastrodiae coarse powder weight 8 times amount volume fraction is the ethanol of 60%, soak 6 hours, supersound extraction twice at 40 DEG C of temperature, each 30 minutes, supersonic frequency was 20kHz, filter, merging filtrate, when filtrate reduced in volume is to 60 DEG C, relative density is the clear paste of 1.10, obtains Rhizoma Gastrodiae extract；
(2) Fructus Kochiae, Folium Artemisiae Argyi, Herba Menthae, Radix Saposhnikoviae, the Radix Astragali, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Scrophulariae, Periostracum Cicadae, Radix Angelicae Sinensis, Cortex Moutan, Flos Lonicerae, Herba Schizonepetae, Fructus Mori and Radix Glycyrrhizae are taken, add the distilled water of above-mentioned 3 times of weight of medical material total amount, soak 12 hours, decoct 2 hours, filter, merging filtrate, concentration, obtaining 60 DEG C of relative densities is the extractum of 1.20；
(3) extractum that Rhizoma Gastrodiae extract step (1) obtained obtains with step (2) mixes, and dry, pulverize, adds corresponding adjuvant, make tablet.
Embodiment 2
Embodiment 2 Chinese medicine composition is prepared from by the raw material of following parts by weight:
20 parts of Rhizoma Gastrodiae, the Fructus Kochiae 16 parts, Folium Artemisiae Argyi 18 parts, Herba Menthae 10 parts, Radix Saposhnikoviae 18 parts, the Radix Astragali 13 parts, the Radix Paeoniae Alba 14 parts, Radix Rehmanniae Preparata 16 parts, Radix Scrophulariae 16 parts, Periostracum Cicadae 12 parts, Radix Angelicae Sinensis 12 parts, Cortex Moutan 10 parts, Flos Lonicerae 8 parts, Herba Schizonepetae 7 parts, Fructus Mori 10 parts and 16 parts of Radix Glycyrrhizae.
Preparation method:
(1) take Rhizoma Gastrodiae to clean, crushed after being dried, crosses 80 mesh sieves, and adding Rhizoma Gastrodiae coarse powder weight 10 times amount volume fraction is the ethanol of 70%, soak 10 hours, supersound extraction twice at 50 DEG C of temperature, each 40 minutes, supersonic frequency was 25kHz, filter, merging filtrate, when filtrate reduced in volume is to 60 DEG C, relative density is the clear paste of 1.15, obtains Rhizoma Gastrodiae extract；
(2) Fructus Kochiae, Folium Artemisiae Argyi, Herba Menthae, Radix Saposhnikoviae, the Radix Astragali, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Scrophulariae, Periostracum Cicadae, Radix Angelicae Sinensis, Cortex Moutan, Flos Lonicerae, Herba Schizonepetae, Fructus Mori and Radix Glycyrrhizae are taken, add the distilled water of above-mentioned 4 times of weight of medical material total amount, soak 18 hours, decoct 3 hours, filter, merging filtrate, concentration, obtaining 60 DEG C of relative densities is the extractum of 1.22；
(3) extractum that Rhizoma Gastrodiae extract step (1) obtained obtains with step (2) mixes, and dry, pulverize, adds corresponding adjuvant, make capsule.
Embodiment 3
Embodiment 3 Chinese medicine composition is prepared from by the raw material of following parts by weight:
16 parts of Rhizoma Gastrodiae, the Fructus Kochiae 10 parts, Folium Artemisiae Argyi 12 parts, Herba Menthae 6 parts, Radix Saposhnikoviae 12 parts, the Radix Astragali 8 parts, the Radix Paeoniae Alba 9 parts, Radix Rehmanniae Preparata 15 parts, Radix Scrophulariae 13 parts, Periostracum Cicadae 10 parts, Radix Angelicae Sinensis 8 parts, Cortex Moutan 7 parts, Flos Lonicerae 6 parts, Herba Schizonepetae 4 parts, Fructus Mori 7 parts and 12 parts of Radix Glycyrrhizae.
Preparation method:
(1) take Rhizoma Gastrodiae to clean, crushed after being dried, crosses 100 mesh sieves, and adding Rhizoma Gastrodiae coarse powder weight 12 times amount volume fraction is the ethanol of 80%, soak 12 hours, supersound extraction twice at 60 DEG C of temperature, each 50 minutes, supersonic frequency was 30kHz, filter, merging filtrate, when filtrate reduced in volume is to 60 DEG C, relative density is the clear paste of 1.20, obtains Rhizoma Gastrodiae extract；
(2) Fructus Kochiae, Folium Artemisiae Argyi, Herba Menthae, Radix Saposhnikoviae, the Radix Astragali, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Scrophulariae, Periostracum Cicadae, Radix Angelicae Sinensis, Cortex Moutan, Flos Lonicerae, Herba Schizonepetae, Fructus Mori and Radix Glycyrrhizae are taken, add the distilled water of above-mentioned 5 times of weight of medical material total amount, soak 24 hours, decoct 4 hours, filter, merging filtrate, concentration, obtaining 60 DEG C of relative densities is the extractum of 1.25；
(3) extractum that Rhizoma Gastrodiae extract step (1) obtained obtains with step (2) mixes, and dry, pulverize, adds corresponding adjuvant, make pill.
Experimental example 1:The antipruritic Effect study of Chinese medicine composition of the present invention
1, experimental animal: take ICR mice (SPF level) 60, male, body weight (22.5 ± 0.16g), it is randomly divided into 5 groups, often group 12.
2, trial drug and dosage regimen:
Treatment: gavage gives the capsule that the embodiment of the present invention 2 prepares.Take 3 groups of rats, be labeled as high dose group (3g/kg), middle dosage group (1.5g/kg) and low dose group (0.5g/kg).
Positive controls: positive control drug is WUSHE ZHIYANG WAN (the quasi-word Z44020044 of traditional Chinese medicines, Jiangxi QingFeng Pharmacy Co., Ltd), and dosage is 1g/kg.
3, experimental technique: in first 7 days of modeling, each administration group pressed 0.2ml/10g body weight gastric infusion every time, 1 time/d, continuous 7d, and model control group is with distilled water gavage.After 7d last administration 1h, to each group of mouse tail vein injection 0.025% dextran-40, dosage is 0.05ml/10g.Whole body each several part is stung as pruritus indication using mice fore paw scratch trunk, mouth of head, rear solid end of scratching.
4, result of the test: Chinese medicine composition of the present invention is as shown in table 1 below to the mouse model antipruritic Effect study result of dextran-40 inducing endogenous histamine release.
Table 1
Note: compare with model control group, administration group* P< 0.05,** P< 0.01.
Antipruritic effect can be evaluated by latent time and the pruritus number of times that first time pruritus occurs.Latent time can reflect the intensity and persistence that the speed that endogenous histamine discharges, pruritus number of times then reflect that endogenous histamine discharges.By upper table 1 it can be seen that pruritus number of times and the pruritus persistent period of the Chinese medicine composition high dose group of the present invention and middle dosage group substantially reduce, statistically significant with model control group comparing difference (P< 0.01).
Therefore, the mouse model of dextran-40 inducing endogenous histamine release is had good antipruritic effect by Chinese medicine composition of the present invention, and it can obviously reduce mice pruritus number of times, significantly reduces the pruritus persistent period.
Experimental example: 2:The clinical trial of Chinese medicine composition of the present invention
(1) study subject selects
Tcm diagnosis standard: the content with reference to " diagnosis basis of pruritus " of " Chinese medical disease Standardization of diagnosis and curative effect " (2012 editions) and " new Chinese medicine guideline of clinical investigations " is drafted.
Diagnostic criteria is:
(1) general skin pruritus: whole body skin pruritus is without determining place or general property skin pruritus, and night attaches most importance to, xerosis cutis, grabs clearly.
(2) limitation skin pruritus: gargalesthesia is confined to position, health certain more, as anus, cysthus, scrotum are published, infiltration plumpness, lichen sample pathological changes and eczematization are seen in affected part due to long-term pruritus.
(3) deficiency of YIN wind contains disease diagnosis
Primary symptom: 1. skin pruritus, becoming severe at night or rise one after another；2. red tongue or partially red, Artemusia lactiflora Wall. or flower stripping；3. skin is scorching hot or dry.
Secondary disease: 1. scratch again and again or is lichen sample pathological changes；2. dysphoria with smothery sensation；3. dry mouth and tougue；4. difficulty in defecation；5. stringy and thready pulse or stringy and thready pulse number.
(2) clinical trial protocol
1, physical data
Choose patient's totally 120 example gone to a doctor in January ,-2014 in January, 2012 at Dermatology Outpatient Department.Wherein male 85 example, women 35 example, age 55-85 year, the course of disease 4 months-8 years, year mean age (62.56 ± 10.43).This group MethodsThe cases enrolled standard:
1. skin pruritus betides more than 55 years old old people's age；
2. there is no constitutional erythra；
3. can secondary scratch, blood crusts, even lichenification, pigmentation.
All patients are randomly divided into treatment group, matched group, often organize 60 examples.Two groups of patients in age, sex, disease time, previously health history, ordinary circumstance etc. no difference of science of statistics (P> 0.05), there is comparability.
2, test method
Treatment group: trial drug is the pill of the embodiment of the present invention 3 preparation, and 2 times on the one, 7 days be a course for the treatment of, evaluates curative effect after 2 courses for the treatment of.
Matched group: control drug is WUSHE ZHIYANG WAN (the quasi-word Z44020044 of traditional Chinese medicines, Jiangxi QingFeng Pharmacy Co., Ltd), takes according to suggestion taking dose, and 3 times on the one, 7 days be a course for the treatment of, evaluates curative effect after 2 courses for the treatment of.
3, curative effect determinate standard
Criterion of therapeutical effect: with reference to " practical combination of Chinese and Western medicine diagnoses and treatment " skin pruritus criterion of therapeutical effect.
1. cure: pruritus and skin secondary lesion scratch, blood crusts, pachylosis disappearance；
2. effective: without obvious pruritus, Secondary cases skin lesion disappears more than 80%；
3. effective: skin lesion is disappeared 50-70%；
4. invalid: pruritus is without alleviating, and secondary skin lesion disappears less than 20%, still has and increase the weight of during treatment.
4, therapeutic outcome, as shown in table 2
Table 2 clinical treatment outcome
Upper table 2 clinical testing data shows, matched group cure rate is 56.7%, and treat up to 75.0%, total effective rate is 95.0%, higher than matched group, illustrates that traditional Chinese medicine composition for treating effect of the present invention is better than WUSHE ZHIYANG WAN, also demonstrate that pharmaceutical composition of the present invention is high to the cure rate of senile skin pruritus, therapeutic effect is notable, can as clinical treatment skin pruritus drug use, and clinical generalization value is high.
Claims (5)
1. the method for the Chinese medicine composition preparing treatment senile skin pruritus, it is characterised in that comprise the following steps:
(1) weigh Rhizoma Gastrodiae 10-20 part by weight to clean, crushed after being dried, crosses 80-100 mesh sieve, and adding Rhizoma Gastrodiae coarse powder weight 8-12 times amount volume fraction is the ethanol of 60-80%, soak 6-12 hour, supersound extraction twice at 40-60 DEG C of temperature, each 30-50 minute, supersonic frequency was 20-30kHz, filter, merging filtrate, when filtrate reduced in volume is to 60 DEG C, relative density is the clear paste of 1.10-1.20, obtains Rhizoma Gastrodiae extract；
(2) Fructus Kochiae 4-16 part, Folium Artemisiae Argyi 8-18 part, Herba Menthae 4-10 part, Radix Saposhnikoviae 10-18 part, Radix Astragali 6-13 part, Radix Paeoniae Alba 6-14 part, Radix Rehmanniae Preparata 9-16 part, Radix Scrophulariae 8-16 part, Periostracum Cicadae 6-12 part, Radix Angelicae Sinensis 4-12 part, Cortex Moutan 3-10 part, Flos Lonicerae 4-8 part, Herba Schizonepetae 2-7 part, Fructus Mori 5-10 part and Radix Glycyrrhizae 6-16 part are weighed by weight, add the distilled water of above-mentioned total amount 3-5 times of weight of medical material, soak 12-24 hour, decoct 2-4 hour, filter, merging filtrate, concentration, obtaining 60 DEG C of relative densities is the extractum of 1.20-1.25；
(3) extractum that Rhizoma Gastrodiae extract step (1) obtained obtains with step (2) mixes, and dry, pulverize, to obtain final product.
2. the method for the Chinese medicine composition of preparation treatment senile skin pruritus as claimed in claim 1, it is characterized in that, the weight portion of the raw material of described Chinese medicine composition is as follows: 10 parts of Rhizoma Gastrodiae, the Fructus Kochiae 4 parts, Folium Artemisiae Argyi 8 parts, Herba Menthae 4 parts, Radix Saposhnikoviae 10 parts, the Radix Astragali 6 parts, the Radix Paeoniae Alba 6 parts, Radix Rehmanniae Preparata 9 parts, Radix Scrophulariae 8 parts, Periostracum Cicadae 6 parts, Radix Angelicae Sinensis 4 parts, Cortex Moutan 3 parts, Flos Lonicerae 4 parts, Herba Schizonepetae 2 parts, Fructus Mori 5 parts and 6 parts of Radix Glycyrrhizae.
3. the method for the Chinese medicine composition of preparation treatment senile skin pruritus as claimed in claim 1, it is characterized in that, the weight portion of the raw material of described Chinese medicine composition is as follows: 20 parts of Rhizoma Gastrodiae, the Fructus Kochiae 16 parts, Folium Artemisiae Argyi 18 parts, Herba Menthae 10 parts, Radix Saposhnikoviae 18 parts, the Radix Astragali 13 parts, the Radix Paeoniae Alba 14 parts, Radix Rehmanniae Preparata 16 parts, Radix Scrophulariae 16 parts, Periostracum Cicadae 12 parts, Radix Angelicae Sinensis 12 parts, Cortex Moutan 10 parts, Flos Lonicerae 8 parts, Herba Schizonepetae 7 parts, Fructus Mori 10 parts and 16 parts of Radix Glycyrrhizae.
4. the method for the Chinese medicine composition of preparation treatment senile skin pruritus as claimed in claim 1, it is characterized in that, the weight portion of the raw material of described Chinese medicine composition is as follows: 16 parts of Rhizoma Gastrodiae, the Fructus Kochiae 10 parts, Folium Artemisiae Argyi 12 parts, Herba Menthae 6 parts, Radix Saposhnikoviae 12 parts, the Radix Astragali 8 parts, the Radix Paeoniae Alba 9 parts, Radix Rehmanniae Preparata 15 parts, Radix Scrophulariae 13 parts, Periostracum Cicadae 10 parts, Radix Angelicae Sinensis 8 parts, Cortex Moutan 7 parts, Flos Lonicerae 6 parts, Herba Schizonepetae 4 parts, Fructus Mori 7 parts and 12 parts of Radix Glycyrrhizae.
5. the method for the Chinese medicine composition of the preparation treatment senile skin pruritus as described in as arbitrary in claim 1-4, it is characterised in that: described Chinese medicine composition is granule, pill, powder, tablet or capsule.
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| CN102920959A (en) * | 2012-11-22 | 2013-02-13 | 张继成 | Capsule for removing pathogenic heat from blood |
| CN103933206A (en) * | 2014-04-20 | 2014-07-23 | 文成县刀锋科技有限公司 | Medicament lotion for treating skin itch of old people |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102920959A (en) * | 2012-11-22 | 2013-02-13 | 张继成 | Capsule for removing pathogenic heat from blood |
| CN103933206A (en) * | 2014-04-20 | 2014-07-23 | 文成县刀锋科技有限公司 | Medicament lotion for treating skin itch of old people |
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Application publication date: 20160720 |