CN105770498B - A kind of Chinese medicinal liquor and preparation method thereof for treating hemiplegia after ischemia apoplexy - Google Patents
A kind of Chinese medicinal liquor and preparation method thereof for treating hemiplegia after ischemia apoplexy Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract
The invention belongs to a kind of Chinese medicinal liquor and preparation method thereof for treating hemiplegia after ischemia apoplexy, the Chinese medicinal liquor is made of the bulk pharmaceutical chemicals of following portions by weight: 40-240 parts of Radix Astragali, 40-60 parts of Caulis Spatholobi, 6-12 parts of leech, 20-60 parts of pheretima, 20-40 parts of zaocys dhumnade, 12-40 parts of Rhizoma Gastrodiae, 40-60 parts of berba aristolochiae mollissimae, 800-5000 parts of brewing grains white spirit.Radix Astragali, Caulis Spatholobi, leech, pheretima, zaocys dhumnade, Rhizoma Gastrodiae, berba aristolochiae mollissimae, Chinese medicinal liquor made of brewing grains white spirit, include nourishing qi and blood, the function of disperse blood stasis and dredge collateral, for treat blood stagnancy due to deficiency of QI occurs after ischemia apoplexy hemiplegia, suffering limb it is weak and limp do not have to, the diseases such as numb joint stuffiness, it is significant in efficacy.
Description
Technical field
The invention belongs to liquid medicine technical fields, and in particular to it is a kind of treat after ischemia apoplexy the Chinese medicinal liquor of hemiplegia and its
Preparation method.
Background technique
Apoplexy is due to imbalance of yin and yang, and qi and blood is inverse disorderly, and upper criminal is caused by brain.Stroke in convalescent stage, deficiency of qi and blood, cause blood without
Power, the resistance of blood vessels numbness occur hemiplegia, suffering limb it is weak and limp do not have to, numbness, joint stuffiness etc. are primary symptom.And merely with western medicine sheet
Disease, effect is unobvious, and most of patients easily leaves the sequelae such as disabled or aphasis, brings great pain to patient.
Summary of the invention
Clinical symptoms, treatment ischemic safe and reliable, convenient to take can be significantly improved the object of the present invention is to provide a kind of
The Chinese medicinal liquor and preparation method thereof of hemiplegia after property headstroke.
To achieve the above object, the technical solution adopted by the present invention is that, it is a kind of to treat after ischemia apoplexy in hemiplegia
Liquid medicine is made of the bulk pharmaceutical chemicals of following portions by weight: 40-240 parts of Radix Astragali, 40-60 parts of Caulis Spatholobi, 6-12 parts of leech, pheretima 20-
60 parts, 20-40 parts of zaocys dhumnade, 12-40 parts of Rhizoma Gastrodiae, 40-60 parts, 40 ~ 60 ° 800-5000 parts of brewing grains white spirit of berba aristolochiae mollissimae.
Preferably, after the described treatment ischemia apoplexy hemiplegia Chinese medicinal liquor, by the bulk pharmaceutical chemicals system of following portions by weight
At: 120 parts of Radix Astragali, 50 parts of Caulis Spatholobi, 8 parts of leech, 40 parts of pheretima, 30 parts of zaocys dhumnade, 30 parts of Rhizoma Gastrodiae, 50 parts of berba aristolochiae mollissimae, 40 ~
60 ° 1200 parts of brewing grains white spirit.
The preparation method of the Chinese medicinal liquor of hemiplegia after the described treatment ischemia apoplexy: by Radix Astragali, Caulis Spatholobi, leech,
Dragon, zaocys dhumnade, Rhizoma Gastrodiae, berba aristolochiae mollissimae are added to the container after being pulverized and mixed, and 40 ~ 60 ° of brewing grains white spirits are added, and are impregnated 25 ~ 35 days, point
Separate out medicated liquor to get.
Usage and dosage: oral, a 20ml, one takes daily twice.
The pharmacology of Chinese medicinal liquor of the present invention is as follows:
Brewing grains white spirit: acrid flavour, sweet, extremely hot in nature, it can cold dispelling, promoting circulation of blood, dredging collateral.With easy diverging, the characteristic of drug effect is encouraged.With
Wine is conducive to the leaching of effective component of chinese medicine as solvent is extracted.Vina can enhance expelling wind and clearing away cold again, promoting blood circulation and removing obstruction in channels, and the scattered stasis of blood is stopped
The function of pain.
Radix Astragali: sweet in flavor, slightly warm in nature, returns spleen, lung channel.Can tonifying Qi with green blood and row it is stagnant.Half not all right to blood stagnancy due to deficiency of QI
Body is unsuccessful or numb and weak and limp inability, and compatibility pheretima curative effect is more preferably.It is also used to deficiency of vital energy water-wet and loses phlegm wet, oedema caused by fortune etc.
Disease.
Caulis Spatholobi: bitter, sweet, warm-natured, return liver warp.The nourshing blood and promoting blood circulation of this product energy and relaxing tendons and activating collaterals, control quadriplegia after apoplexy,
The medicine of compatibility qi and activate blood circulation dredging collateral is the same as more excellent with curative effect.
Leech: taste is salty, bitter, mild-natured, return liver warp.This product can enter blood system, dissipating blood stasis with potent drugs, and the high effect of power is macro.Fresh leech saliva
Hirudin in liquid gland, hirudin can prevent effect of the fibrin ferment to fibrinogen, prevent blood clotting.
Pheretima: taste is salty, cold in nature, returns liver, spleen, bladder meridian.Pheretima is longer than current channels and collaterals, for treating blood stagnancy due to deficiency of QI, half body
Unsuccessful equal diseases.
Zaocys dhumnade: mild-natured, sweet in flavor, return liver warp.This product can search ailment said due to cold or exposure, and degrading the channel is controlled brothers and delayed, cannot stretch the migratory arthralgia of act
Deng.
Rhizoma Gastrodiae: sweet in flavor, mild-natured, return liver warp.Rhizoma Gastrodiae can dispel exogenous wind, degrading the channel, for treating wind apoplex involving the channels and collaterals, hands and feet caused by paralysis,
The diseases such as extremity numbness.
Berba aristolochiae mollissimae: acrid flavour, hardship, mild-natured, return liver warp.With the function removed obstruction in channels to relieve pain, for diseases such as extremity numbness.
The beneficial effect comprise that Radix Astragali, Caulis Spatholobi, leech, pheretima, zaocys dhumnade, Rhizoma Gastrodiae, berba aristolochiae mollissimae, pure grain
Chinese medicinal liquor made of white wine, has nourishing qi and blood, and the function of disperse blood stasis and dredge collateral occurs for blood stagnancy due to deficiency of QI after treating ischemia apoplexy
Hemiplegia, suffering limb it is weak and limp do not have to, the diseases such as numb joint stuffiness, it is significant in efficacy.
Specific embodiment
Technical solution of the present invention is described in further detail below in conjunction with specific embodiment, but protection model of the invention
It encloses and is not limited only to this.
Embodiment 1
A kind of Chinese medicinal liquor for treating hemiplegia after ischemia apoplexy, is made: Radix Astragali 120 of the bulk pharmaceutical chemicals of following portions by weight
50 parts, 50 ° part, 50 parts of Caulis Spatholobi, 8 parts of leech, 40 parts of pheretima, 30 parts of zaocys dhumnade, 30 parts of Rhizoma Gastrodiae, berba aristolochiae mollissimae brewing grains white spirits 1200
Part.
The preparation method of the Chinese medicinal liquor of hemiplegia after the described treatment ischemia apoplexy: by Radix Astragali, Caulis Spatholobi, leech,
Dragon, zaocys dhumnade, Rhizoma Gastrodiae, berba aristolochiae mollissimae are added to the container after being pulverized and mixed, and 50 ° of brewing grains white spirits are added, and are impregnated 30 days, and drug is separated
Wine liquid to get.
Usage and dosage: oral, a 20ml, one takes daily twice.
Embodiment 2
A kind of Chinese medicinal liquor for treating hemiplegia after ischemia apoplexy, is made: Radix Astragali 40 of the bulk pharmaceutical chemicals of following portions by weight
40 parts, 60 ° part, 60 parts of Caulis Spatholobi, 6 parts of leech, 20 parts of pheretima, 20 parts of zaocys dhumnade, 12 parts of Rhizoma Gastrodiae, berba aristolochiae mollissimae brewing grains white spirits 800
Part.
The preparation method of the Chinese medicinal liquor of hemiplegia after the described treatment ischemia apoplexy: by Radix Astragali, Caulis Spatholobi, leech,
Dragon, zaocys dhumnade, Rhizoma Gastrodiae, berba aristolochiae mollissimae are added to the container after being pulverized and mixed, and 60 ° of brewing grains white spirits are added, and are impregnated 35 days, and drug is separated
Wine liquid to get.
Usage and dosage: oral, a 20ml, one takes daily twice.
Embodiment 3
A kind of Chinese medicinal liquor for treating hemiplegia after ischemia apoplexy, is made: Radix Astragali 240 of the bulk pharmaceutical chemicals of following portions by weight
60 parts, 40 ° part, 40 parts of Caulis Spatholobi, 12 parts of leech, 60 parts of pheretima, 40 parts of zaocys dhumnade, 40 parts of Rhizoma Gastrodiae, berba aristolochiae mollissimae brewing grains white spirits
5000 parts.
The preparation method of the Chinese medicinal liquor of hemiplegia after the described treatment ischemia apoplexy: by Radix Astragali, Caulis Spatholobi, leech,
Dragon, zaocys dhumnade, Rhizoma Gastrodiae, berba aristolochiae mollissimae are added to the container after being pulverized and mixed, and 40 ° of brewing grains white spirits are added, and are impregnated 25 days, and drug is separated
Wine liquid to get.
Usage and dosage: oral, a 20ml, one takes daily twice.
Clinical test
1.1 general information
From in January, 2010 to 2 months 2016, accepts for medical treatment and screen 100 after ischemia apoplexy in hemiplegic patient.All diseases
Example is made a definite diagnosis through the multiple inspections such as physical examination and head CT, and bad without organ functions such as serious liver, kidney, the hearts.And it is randomly divided into and controls
Treatment group 50, wherein male 32, female 18, the age 26-70 years old, average age 48.6 years old.Control group 50, wherein male 31,
Female 19, the age 27-71 years old, average age 49 years old.Two groups of patients the age, in terms of without significant difference (p ﹥
0.05) it, is comparable, see Table 1 for details.
1 two groups of case ordinary circumstances of table compare
| Group (example) | Male/female | Average age (year) | Basal ganglia region infraction | Cerebellar infarction | Brain stem infarct |
| Treatment group (50) | 32/18 | 48.6 | 41 | 6 | 3 |
| Control group (50) | 31/19 | 49 | 43 | 5 | 2 |
Note: two groups are compared: p ﹥ 0.05.
1.2 diagnostic criteria
1. having hypertension, diabetes or dyslipidemia medical history；2. having the sings and symptoms of focal neurologic impairment, such as
The symptoms such as hemiplegia, hemidysesthesia；3. head CT shows: there is low-density lesion in intracerebral.
1.3 treatment method
Control group: using western medicine routine treatment, adjusts blood pressure Irbesartan, adjusts blood lipid Atorvastatin calcium,
He takes symptomatic treatment.
Treatment group: on the basis of control group western medicine routine treatment, Chinese medicinal liquor, the system in the embodiment of the present invention 1 are added
Preparation Method and application method.
Two groups after treatment 8 weeks, two groups carry out head CT examination before and after treatment, and observation clinical symptoms improve situation.
1.4 therapeutic evaluation
1.4.1 effective: clinical symptoms significantly improve, and limb function obviously restores, and muscular strength is at III grade or more.
1.4.2 effectively: the more apparent improvement of clinical symptoms, limb function obviously restore, and muscular strength is between II-III grade.
1.4.3 invalid: clinical symptoms are without improvement, and limb function is without recovery, and muscular strength is at II grade or less.
1.5 statistical method
Data are indicated with rate, using x2It examines, is that difference is statistically significant with p < 0.05.
1.6 result
1.6.1 pretherapy and post-treatment two groups of clinical symptoms improve situation and compare:
Treatment group adds Chinese medicinal liquor clinical symptoms improvement rate of the present invention on the basis of control group uses western medicine routine treatment merely
(93.98%), hence it is evident that use clinical symptoms improvement rate (46.51%) after western medicine routine treatment merely better than control group, see Table 2 for details.
2 two groups of table pretherapy and post-treatment clinical symptoms improve number of cases and improvement rate
Note: improve=effective+effectively (p < 0.05).
1.6.2 adverse reaction
Two groups are showed no obvious adverse reaction, but the function such as children, pregnant woman, hypertension and severe cardiac, liver, kidney during treatment
Can not full person, forbid taking the Chinese medicinal liquor in the present invention.
Typical case
Case 1
Mr. Li, male, 58 years old, construction worker, the township Xi Xishao Li Xi Shao Cun people.On May 16th, 2015 " after cerebral infarction
Hemiplegia " is medical.When labour, there is left limb inability, dysphonia before 6 days suddenly in patient.The treatment of Zeng Ben village health posts,
Less effective, therefore come at inventor to seek medical advice.Symptoms include: dizzy, left limb limitation of activity, hand fiber crops, aphasia, dimly red tongue,
Whitish tongue is greasy, wiry and rolling pulse.Head CT shows: right side basal ganglia region, cerebral infarction stove by ventricular anterior horn.
Dialectical Analyses: addiction delicious food savoury usually, burnt in cause to lose fortune, accumulatively wet raise phlegm disturb clear key in phlegm wet, and brain network numbness hinders not
It is logical, therefore see dizziness, aphasia.Phlegm stagnating in meridian, qi and blood is obstructed, then sees hemiplegia, hand fiber crops.Whitish tongue is greasy, and wiry and rolling pulse is phlegm
Wet interior Sheng as.Dark tongue quality is the card of simultaneous hemostasis.
Diagnosis: headstroke (phlegm stagnation in collateral)
The rules for the treatment of: replenishing qi to invigorate the spleen, resolving sputum, blood-nourishing, disperse blood stasis and dredge collateral.
Recipe: 1 Chinese medicinal liquor of the embodiment of the present invention and preparation method, application method.
Western medicine: 1. platelet aggregation-against Bayaspirin.2. reducing blood lipid Atorvastatin calcium.3. neuroprotection
Treatment Edaravone etc., remaining gives symptomatic treatment.
It is treated after two weeks, dizziness disappears, remaining all symptom mitigates.After treatment 6 weeks, hemiplegia, hand fiber crops disappear,
Speech is gradually clear and fully recovers.It advises and continues to take in the present invention 1 Chinese medicinal liquor of embodiment 2 months to consolidate curative effect.By multiple follow-up,
It has not relapsed so far.
Case 2
Zhao so-and-so, male, 60 years old, peasant was the Nanyue County township Qian Kou people from the village Bei Chouzhuan, on March 19th, 2013, with " cerebral infarction
After death hemiplegia " is medical, and patient when labour, right side myasthenia of limbs, aphasia occurred before 2 days suddenly.Once in county hospital, disease
Shape gradually aggravates, and seeks medical advice at emergency inventor.Symptoms include: right half body limbs are unsuccessful, and weak and limp inability, glossolalia, the tip of the tongue is to the left, tongue
Whitish tongue, dimly pale tongue, thready and hesitant pulse.Head CT shows: left side basal ganglia region and left side occipital lobe cerebral infarction stove.
Dialectical Analyses: patient is worn with age, and the deficiency of vital energy is caused blood vessels cannot to be agitated to run, and blood retardance, stasis blocking brain arteries and veins is then shown in half
Body is unsuccessful, the weak and limp inability of limbs, the tip of the tongue deflection, aphasia.Dimly pale tongue, thready and hesitant pulse be qi deficiency to blood stasis as.
Diagnosis: headstroke (qi deficiency to blood stasis)
The rules for the treatment of: nourishing qi and blood, disperse blood stasis and dredge collateral
Recipe: 1 Chinese medicinal liquor of the embodiment of the present invention and preparation method, application method.
Western medicine: 1. lipid-loweringing Atorvastatin calcium etc., 2. platelet aggregation-against Bayaspirin, 3. neuroprotection
The symptomatic treatments such as treatment Edaravone.
It is treated after two weeks, hemiplegia, aphasia is gradually recovered, and after treatment 6 weeks, right side limb function restores just
Often, speech understands, Kou She has tiltedly restored to normal and fully recover.Advise continue to take in the present invention 1 Chinese medicinal liquor of embodiment 2 months with
Consolidate curative effect.By multiple follow-up, have not relapsed so far.
Claims (3)
1. a kind of Chinese medicinal liquor for treating hemiplegia after ischemia apoplexy, which is characterized in that by the bulk pharmaceutical chemicals system of following portions by weight
At: 40-240 parts of Radix Astragali, 40-60 parts of Caulis Spatholobi, 6-12 parts of leech, 20-60 parts of pheretima, 20-40 parts of zaocys dhumnade, Rhizoma Gastrodiae 12-40
Part, 40-60 parts of berba aristolochiae mollissimae, 800-5000 parts of brewing grains white spirit.
2. treating the Chinese medicinal liquor of hemiplegia after ischemia apoplexy as described in claim 1, which is characterized in that by following weight parts
Several bulk pharmaceutical chemicals are made: 120 parts of Radix Astragali, 8 parts of leech, 40 parts of pheretima, 30 parts of zaocys dhumnade, 30 parts of Rhizoma Gastrodiae, seeks bone at 50 parts of Caulis Spatholobi
50 parts of wind, 1200 parts of brewing grains white spirit.
3. treating the preparation method of the Chinese medicinal liquor of hemiplegia after ischemia apoplexy as claimed in claim 1 or 2, feature exists
In: Radix Astragali, Caulis Spatholobi, leech, pheretima, zaocys dhumnade, Rhizoma Gastrodiae, berba aristolochiae mollissimae are crushed, are added to the container after mixing, pure grain is added
White wine, impregnate 25 ~ 35 days, isolate medicated liquor to get.
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