CN105749040A - Hpyerglycemic compound preparation - Google Patents
Hpyerglycemic compound preparation Download PDFInfo
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- CN105749040A CN105749040A CN201610219209.6A CN201610219209A CN105749040A CN 105749040 A CN105749040 A CN 105749040A CN 201610219209 A CN201610219209 A CN 201610219209A CN 105749040 A CN105749040 A CN 105749040A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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Abstract
The invention provides a hpyerglycemic compound preparation which is mainly prepared from the following raw materials in parts by weight: 0.1 part of astragalus polysaccharide, 30-50 parts of a water-soluble carrier material, 5-25 parts of cinnamon, 15-25 parts of cortex lycii radicis, 10-20 parts of wild chrysanthemum flowers, 10-30 parts of coix seeds, 5-35 parts of honeysuckle stems and 80-120 parts of a framework material. Compared with the prior art, the obtained hpyerglycemic compound preparation is free of a toxic or side effect, comprehensive in curative effect, and significant in effect; blood glucose can be effectively reduced; disposable medication of multiple medicines is achieved; the hpyerglycemic compound preparation has certain development value.
Description
Technical field
The present invention relates to a kind of hypoglycemic compound preparation, belong to technical field of traditional Chinese medicine preparation.
Background technology
Hyperglycemia is that in patient's blood, the content of sugar the most persistently exceeds normal level.Its criterion is mainly blood sugar
Value.Blood sugar raises, and glucose in urine increases, and can cause osmotic diuresis, thus cause the symptom of diuresis；Blood sugar raises, in a large number
Loss of moist, blood osmotic pressure also can raise accordingly, high blood ooze can the thirst center of Hypothalamic Stimulation, thus cause thirsty,
The symptom of many drinks；Due to the shortage that insulin is relative or absolute, internal glucose is caused not to be utilized, protein and fat
Fat consumption increases, thus cause weak, lose weight；In order to compensate the sugar of loss, maintaining body activities, needs are many
Feed；Which forms typical " three-many-one-little " symptom.Many drinks of diabetic, diuresis symptom are tight with the state of an illness
Weight degree is proportional.Moreover, it is noted that patient eats the most, blood sugar is the highest, loses sugar the most in urine,
Hunger is the most severe, has ultimately resulted in vicious circle.
Therefore, the treatment of current hyperglycaemia, generally require multi-medicament with the use of, not only curative effect is difficult to many-side and takes into account,
And patient adaptability is poor.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the present invention provides a kind of hypoglycemic compound preparation.
Technical scheme: for achieving the above object, the invention provides a kind of hypoglycemic compound preparation, and it is mainly by weighing as follows
Made by the bulk drug of amount part:
Astragalus polyose 0.1 part, water soluble carrier material 30-50 part, Chinese cassia tree 5-25 part, root bark of Chinese wolf-berry 15-25 part,
Mother chrysanthemum 10-20 part, heart of a lotus seed benevolence 10-30 part, caulis lonicerae 5-35 part, framework material 80-120 part.
As preferably, described hypoglycemic compound preparation is mainly by made by the bulk drug of following weight portion:
Astragalus polyose 0.1 part, water soluble carrier material 35-45 part, Chinese cassia tree 10-20 part, root bark of Chinese wolf-berry 18-22 part,
Mother chrysanthemum 12-18 part, heart of a lotus seed benevolence 15-25 part, caulis lonicerae 15-25 part, framework material 90-110 part.
Preferred as another kind, described hypoglycemic compound preparation is mainly by made by the bulk drug of following weight portion:
Astragalus polyose 0.1 part, water soluble carrier material 30 parts, Chinese cassia tree 5 parts, the root bark of Chinese wolf-berry 15 parts,
Mother chrysanthemum 10 parts, heart of a lotus seed benevolence 10 parts, caulis lonicerae 5 parts, framework material 80 parts.
Preferred as another kind, described hypoglycemic compound preparation is mainly by made by the bulk drug of following weight portion:
Astragalus polyose 0.1 part, water soluble carrier material 50 parts, Chinese cassia tree 25 parts, the root bark of Chinese wolf-berry 25 parts,
Mother chrysanthemum 20 parts, heart of a lotus seed benevolence 30 parts, caulis lonicerae 35 parts, framework material 120 parts.
Preferred as another kind, described water soluble carrier material is Macrogol 4000, PVP, polyoxyethylene, poly-carboxylic
Acid ethene or citric acid.
Preferred as another kind, described framework material is shitosan, sodium carboxymethylcellulose, ethyl cellulose, hydroxypropyl first
Cellulose or PLA.
Preferred as another kind, described hypoglycemic for reducing the hyperglycaemia that type ii diabetes causes.
Described hypoglycemic compound preparation is made up of following steps:
(1) water-soluble carrier material dissolves, and obtains carrier solution, standby；
(2) weigh Chinese cassia tree, the root bark of Chinese wolf-berry, mother chrysanthemum, heart of a lotus seed Renhe caulis lonicerae in proportion, add alcohol extract, obtain alcohol extracting
Residue and extract, extract concentrates, obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extracting residue, add Aqua pure extract, extract concentrates, and obtains Aqueous extracts, standby；
(4) above-mentioned carrier material, Aqueous extracts and astragalus polyose are mixed, high speed dispersion, concentrate, be dried, obtain dispersion
Thing；
(5) framework material is dissolved, add above-mentioned alcohol extract, high speed dispersion, concentrate, be dried, obtain synthetic；
(6) above-mentioned dispersion and synthetic are mixed, to obtain final product.
As preferably:
Described in step (2), alcohol extract is: the 60-80% alcohol reflux extraction of 6-10 times of volume of addition 2 times, every time
2 hours.
Described in step (3), Aqua pure extract is: the water refluxing extraction of 8-12 times of volume of addition 2 times, each 2 hours.
Described in step (4) or (5), the condition of high speed dispersion is: 5000-7000r/min, disperses 30-60 minute.
Beneficial effect: relative to prior art, the hypoglycemic compound preparation of gained of the present invention, have no side effect, curative effect is complete
Face, it is possible to effectively reduce blood sugar, and achieve the disposable medication of multi-medicament, effect is notable, has certain opening
Make an offer value.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Prescription:
Astragalus polyose 0.1 part, Macrogol 4000 30 parts, Chinese cassia tree 5 parts, the root bark of Chinese wolf-berry 15 parts,
Mother chrysanthemum 10 parts, heart of a lotus seed benevolence 10 parts, caulis lonicerae 5 parts, shitosan 80 parts.
Preparation technology:
(1) taking polyethylene glycol 4000 dissolves, and obtains carrier solution, standby；
(2) weigh Chinese cassia tree, the root bark of Chinese wolf-berry, mother chrysanthemum, heart of a lotus seed Renhe caulis lonicerae in proportion, add 80% second of 6 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extracting residue and extract, and extract concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extracting residue, the water refluxing extraction of 8 times of volumes of addition 2 times, each 2 hours, extract was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and astragalus polyose are mixed, 5000r/min, high speed dispersion 60 minutes, dense
Contracting, is dried, obtains dispersion；
(5) shitosan is dissolved, adds above-mentioned alcohol extract, 5000r/min, high speed dispersion 60 minutes, concentrate, be dried,
Obtain synthetic；
(6) above-mentioned dispersion and synthetic are mixed, to obtain final product.
Embodiment 2
Prescription:
Astragalus polyose 0.1 part, PVP 50 parts, Chinese cassia tree 25 parts, the root bark of Chinese wolf-berry 25 parts,
Mother chrysanthemum 20 parts, heart of a lotus seed benevolence 30 parts, caulis lonicerae 35 parts, sodium carboxymethylcellulose 120 parts.
Preparation technology:
(1) take PVP to dissolve, obtain carrier solution, standby；
(2) weigh Chinese cassia tree, the root bark of Chinese wolf-berry, mother chrysanthemum, heart of a lotus seed Renhe caulis lonicerae in proportion, add 60% second of 10 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extracting residue and extract, and extract concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extracting residue, the water refluxing extraction of 12 times of volumes of addition 2 times, each 2 hours, extract was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and astragalus polyose are mixed, 7000r/min, high speed dispersion 30 minutes, dense
Contracting, is dried, obtains dispersion；
(5) sodium carboxymethylcellulose is dissolved, add above-mentioned alcohol extract, 7000r/min, high speed dispersion 30 minutes, dense
Contracting, is dried, obtains synthetic；
(6) above-mentioned dispersion and synthetic are mixed, to obtain final product.
Embodiment 3
Prescription:
Astragalus polyose 0.1 part, polyoxyethylene 40 parts, Chinese cassia tree 15 parts, the root bark of Chinese wolf-berry 20 parts,
Mother chrysanthemum 15 parts, heart of a lotus seed benevolence 20 parts, caulis lonicerae 20 parts, ethyl cellulose 100 parts.
Preparation technology:
(1) take polyoxyethylene to dissolve, obtain carrier solution, standby；
(2) weigh Chinese cassia tree, the root bark of Chinese wolf-berry, mother chrysanthemum, heart of a lotus seed Renhe caulis lonicerae in proportion, add 70% second of 8 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extracting residue and extract, and extract concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extracting residue, the water refluxing extraction of 10 times of volumes of addition 2 times, each 2 hours, extract was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and astragalus polyose are mixed, 6000r/min, high speed dispersion 45 minutes, dense
Contracting, is dried, obtains dispersion；
(5) ethyl cellulose is dissolved, adds above-mentioned alcohol extract, 6000r/min, high speed dispersion 45 minutes, concentrate,
It is dried, obtains synthetic；
(6) above-mentioned dispersion and synthetic are mixed, to obtain final product.
Embodiment 4
Prescription:
Astragalus polyose 0.1 part, polycarboxylic acids ethene 35 parts, Chinese cassia tree 10 parts, the root bark of Chinese wolf-berry 18 parts,
Mother chrysanthemum 12 parts, heart of a lotus seed benevolence 15 parts, caulis lonicerae 15 parts, Hydroxypropyl methylcellulose 90 parts.
Preparation technology:
(1) take polycarboxylic acids ethylene dissolution, obtain carrier solution, standby；
(2) weigh Chinese cassia tree, the root bark of Chinese wolf-berry, mother chrysanthemum, heart of a lotus seed Renhe caulis lonicerae in proportion, add 75% second of 7 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extracting residue and extract, and extract concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extracting residue, the water refluxing extraction of 9 times of volumes of addition 2 times, each 2 hours, extract was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and astragalus polyose are mixed, 6000r/min, high speed dispersion 40 minutes, dense
Contracting, is dried, obtains dispersion；
(5) Hydroxypropyl methylcellulose is dissolved, adds above-mentioned alcohol extract, 6000r/min, high speed dispersion 40 minutes, concentrate,
It is dried, obtains synthetic；
(6) above-mentioned dispersion and synthetic are mixed, to obtain final product.
Embodiment 5
Prescription:
Astragalus polyose 0.1 part, citric acid 45 parts, Chinese cassia tree 20 parts, the root bark of Chinese wolf-berry 22 parts,
Mother chrysanthemum 18 parts, heart of a lotus seed benevolence 25 parts, caulis lonicerae 25 parts, PLA 110 parts.
Preparation technology:
(1) take citric acid to dissolve, obtain carrier solution, standby；
(2) weigh Chinese cassia tree, the root bark of Chinese wolf-berry, mother chrysanthemum, heart of a lotus seed Renhe caulis lonicerae in proportion, add 65% second of 9 times of volumes
Alcohol reflux extracts 2 times, each 2 hours, obtains alcohol extracting residue and extract, and extract concentrates, and obtains alcohol extract, standby；
(3) taking above-mentioned alcohol extracting residue, the water refluxing extraction of 11 times of volumes of addition 2 times, each 2 hours, extract was dense
Contracting, obtains Aqueous extracts, standby；
(4) above-mentioned carrier solution, Aqueous extracts and astragalus polyose are mixed, 6000r/min, high speed dispersion 50 minutes, dense
Contracting, is dried, obtains dispersion；
(5) PLA is dissolved, adds above-mentioned alcohol extract, 6000r/min, high speed dispersion 50 minutes, concentrate, be dried,
Obtain synthetic；
(6) above-mentioned dispersion and synthetic are mixed, to obtain final product.
The hypoglycemic experimental study of experimental example compound preparation of the present invention
Choose 60 laboratory mices (being successfully established hyperglycemia model), be randomly divided into 5 groups, often group 12, point
Wei negative control group, positive controls, embodiment 3-5 group.
Negative control group normal diet；
Positive controls is on the basis of negative control group normal diet, and (astragalus polyose is used to add astragalus polyose in feed
Amount is with embodiment 3,4 and 5 groups), feed；
Embodiment 3,4 and 5 groups, on the basis of negative control group normal diet, gives the embodiment of the present invention 3,4 and
5 products obtained therefroms (wherein astragalus polyose consumption is the most identical with positive controls), same incorporation in feed is fed.
All groups are all administered once daily, and successive administration, after 7 days, investigates the average blood sugar of each group of mouse.
Experimental result see table 1:
Table 1 respectively organize mouse average blood sugar (N=12)
Note: compared with negative control group, * P < 0.05；Compared with positive controls, #P < 0.05.
Can be obtained by upper table 1 result, compared with negative control group, positive controls and the embodiment of the present invention 3,4 and 5
Group mouse is through treatment, and its average blood glucose levels all significantly reduces；Meanwhile, compared with positive controls, the present invention implements
3,4 and 5 groups of mouse of example are after treatment, and its average blood glucose levels all significantly reduces, and 3 groups of effect of reducing blood sugar of embodiment
Fruit is optimum.
Claims (7)
1. a hypoglycemic compound preparation, it is characterised in that it is mainly by made by the bulk drug of following weight portion:
Astragalus polyose 0.1 part, water soluble carrier material 30-50 part, Chinese cassia tree 5-25 part, root bark of Chinese wolf-berry 15-25 part,
Mother chrysanthemum 10-20 part, heart of a lotus seed benevolence 10-30 part, caulis lonicerae 5-35 part, framework material 80-120 part.
Hypoglycemic compound preparation the most according to claim 1, it is characterised in that it is mainly by following weight portion
Bulk drug made by:
Astragalus polyose 0.1 part, water soluble carrier material 35-45 part, Chinese cassia tree 10-20 part, root bark of Chinese wolf-berry 18-22 part,
Mother chrysanthemum 12-18 part, heart of a lotus seed benevolence 15-25 part, caulis lonicerae 15-25 part, framework material 90-110 part.
Hypoglycemic compound preparation the most according to claim 1, it is characterised in that it is mainly by following weight portion
Bulk drug made by:
Astragalus polyose 0.1 part, water soluble carrier material 30 parts, Chinese cassia tree 5 parts, the root bark of Chinese wolf-berry 15 parts,
Mother chrysanthemum 10 parts, heart of a lotus seed benevolence 10 parts, caulis lonicerae 5 parts, framework material 80 parts.
Hypoglycemic compound preparation the most according to claim 1, it is characterised in that it is mainly by following weight portion
Bulk drug made by:
Astragalus polyose 0.1 part, water soluble carrier material 50 parts, Chinese cassia tree 25 parts, the root bark of Chinese wolf-berry 25 parts,
Mother chrysanthemum 20 parts, heart of a lotus seed benevolence 30 parts, caulis lonicerae 35 parts, framework material 120 parts.
Hypoglycemic compound preparation the most according to claim 1, it is characterised in that described water soluble carrier material is
Macrogol 4000, PVP, polyoxyethylene, polycarboxylic acids ethene or citric acid.
Hypoglycemic compound preparation the most according to claim 1, it is characterised in that described framework material be shitosan,
Sodium carboxymethylcellulose, ethyl cellulose, Hydroxypropyl methylcellulose or PLA.
Hypoglycemic compound preparation the most according to claim 1, it is characterised in that described hypoglycemic for reducing II type
The hyperglycaemia that diabetes cause.
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| CN201610219209.6A CN105749040A (en) | 2016-04-11 | 2016-04-11 | Hpyerglycemic compound preparation |
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| CN201610219209.6A CN105749040A (en) | 2016-04-11 | 2016-04-11 | Hpyerglycemic compound preparation |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104082820A (en) * | 2014-06-10 | 2014-10-08 | 秋实草业有限公司 | Hypoglycemic soluble granules containing alfalfa |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104082820A (en) * | 2014-06-10 | 2014-10-08 | 秋实草业有限公司 | Hypoglycemic soluble granules containing alfalfa |
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