CN105748621A - Traditional Chinese medicine preparation for treating diabetic neurovascular lesions - Google Patents

Traditional Chinese medicine preparation for treating diabetic neurovascular lesions Download PDF

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CN105748621A
CN105748621A CN201610276195.1A CN201610276195A CN105748621A CN 105748621 A CN105748621 A CN 105748621A CN 201610276195 A CN201610276195 A CN 201610276195A CN 105748621 A CN105748621 A CN 105748621A
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chinese medicine
radix
medicine preparation
diabetic vascular
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连书光
刘海立
李跃五
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Ruzhou jiren diabetes hospital
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Ruzhou jiren diabetes hospital
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Abstract

A traditional Chinese medicine preparation for treating diabetic neurovascular lesions is prepared from, by weight, 10-30 parts of radix astragali, 8-15 parts of cassia twigs, 15-25 parts of radix paeoniae rubra, 3-8 parts of leeches, 8-15 parts of pseudo-ginseng, 10-18 parts of radix salviae miltiorrhizae, 3-8 parts of processed pangolin and 18-22 parts of beautiful sweetgum fruits.The traditional Chinese medicine preparation for treating diabetic neurovascular lesions can be prepared into decoction or powder or capsules or pills.According to the traditional Chinese medicine for treating diabetic neurovascular lesions, radix astragali, cassia twigs, leeches and processed pangolin with the effects of tonifying qi, activating blood and dredging collaterals serve as main medicinal materials, radix paeoniae rubra, pseudo-ginseng and radix salviae miltiorrhizae serve as adjuvant medicinal materials and have the effect activating and nourishing blood, and beautiful sweetgum fruits are added to serve as an assistant medicinal material; the formula for eliminating pathogens and strengthening vital qi is reasonable, and the medication is mild.The traditional Chinese medicine preparation has a significant treatment effect on diabetic neurovascular lesions, takes effect fast and is low in cost and small in toxic or side effect, and the effective rate can reach 93%.

Description

A kind of Chinese medicine preparation treating diabetic vascular neuropathy
Technical field
The present invention relates to a kind of Chinese medicine preparation, a kind of Chinese medicine preparation treating diabetic vascular neuropathy.
Background technology
Diabetes are one group of metabolic diseases being characterized with hyperglycemia.Hyperglycemia is then owing to defect of insulin secretion or its biological agent are impaired, or both have concurrently and cause.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction.
The symptom of diabetic peripheral neuropathy, clinic symmetrically property pain and paraesthesia, symptoms of lower extremity is common compared with upper limb.Paraesthesia has numbness, ant to walk, worm climbs, generate heat, electric shock sample sensation, often up up to above-knee from far-end toe, and patient wears socks and sensation of wearing glove sample.The case that sensory disturbance is serious may occur in which joint of the lower extremity disease and ulcer.Pain in twinge, causalgia, Drilling pain, it appears that have a pain in bone marrow deep, sometimes acute pain such as amputation pain in daytime light night heavy.The most tactile allergy, the most then can't bear the pressure of cotton-wadded quilt, quilt must be supported.When nervus motorius involves, muscular strength often has going down in various degree, late period the most optimum nutritious amyotrophy.Peripheral neuropathy can bilateral, can be unilateral, can be symmetrical, can be asymmetric, but common with bilateral symmetric property person.
Diabetic macroangiopathy refers to the atherosclerosiss such as aorta, coronary artery, basilar artary, renal artery and peripheral arterial.Compared with non-diabetic people, the prevalence of diabetic population atherosclerosis disease is higher, and age of onset is relatively light, and disease progression is the most very fast.The state of an illness is heavier, case fatality rate is high.About 70%~80% diabetics dies from the macroangiopathy of diabetes.Wherein diabetes and coronary heart disease, myocardial infarction, acute cerebrovascular disease is the major causes of death of diabetes.
Summary of the invention
The present invention seeks to the deficiency for solving above-mentioned technical problem, it is provided that a kind of Chinese medicine preparation treating diabetic vascular neuropathy, the nervus vasculairs pathological changes causing diabetes has significant therapeutic effect.
The present invention solves that above-mentioned technical problem be the technical scheme is that
A kind of Chinese medicine preparation treating diabetic vascular neuropathy, the parts by weight of each crude drug are Radix Astragali 10-30 part, Ramulus Cinnamomi 8-15 part, Radix Paeoniae Rubra 15-25 part, Hirudo 3-8 part, Radix Notoginseng 8-15 part, Radix Salviae Miltiorrhizae 10-18 part, Squama Manis (processed) 3-8 part and Fructus Liquidambaris 18-22 part.
The Chinese medicine preparation of described treatment diabetic vascular neuropathy, the parts by weight of each crude drug are preferably: the Radix Astragali 20 parts, Ramulus Cinnamomi 10 parts, Radix Paeoniae Rubra 20 parts, Hirudo 5 parts, Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Squama Manis (processed) 5 parts and Fructus Liquidambaris 20 parts.
The Chinese medicine preparation of described treatment diabetic vascular neuropathy, can be prepared as decoction, powder, capsule or pill.
The preparation method of described decoction, comprises the following steps:
Step one, take the Radix Astragali, Ramulus Cinnamomi, Radix Paeoniae Rubra according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Hirudo, Radix Notoginseng, Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris, together put into container, add 500-1000 part water, be heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate I and filtering residue I, standby;
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300-500 part part water, be heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate II, standby;
Step 3, by filtrate I and filtrate II mix homogeneously, i.e. prepare decoction.
Step one adds water 1000 parts, and slow fire boils 30min;Adding water 500 parts in step 2, slow fire boils 30min.
The preparation method of described powder, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, mix homogeneously, i.e. obtains powder.
The preparation method of described capsule, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, load No. 1 capsule after mix homogeneously, i.e. obtain capsule.
Provide the benefit that:
1, the present invention treats the Chinese medicine preparation of diabetic vascular neuropathy, with the Radix Astragali, Ramulus Cinnamomi, Hirudo and the Squama Manis (processed) of benefiting QI for activating blood circulation dredging collateral as principal agent, with Radix Paeoniae Rubra, Radix Notoginseng and Radix Salviae Miltiorrhizae as accessory drugs, and nourishing blood and promoting blood circulation, and to add Fructus Liquidambaris be adjuvant;Fuzheng Prescription of getting rid of evils is reasonable, and medication is gentle.
2, the present invention treats the Chinese medicine preparation of diabetic vascular neuropathy, is adjusted to basis with health whole to patient, interacts with the common each crude drug of conventional Chinese medicine prescription and coordinates can at utmost play a role together;Verifying through clinical practice for many years, the present invention treats diabetic vascular neuropathy effect significantly, and effective percentage, up to 93%, takes effect rapidly, and with low cost, and toxic and side effects is little.
Detailed description of the invention
A kind of Chinese medicine preparation treating diabetic vascular neuropathy, the parts by weight of each crude drug are: Radix Astragali 10-30 part, Ramulus Cinnamomi 8-15 part, Radix Paeoniae Rubra 15-25 part, Hirudo 3-8 part, Radix Notoginseng 8-15 part, Radix Salviae Miltiorrhizae 10-18 part, Squama Manis (processed) 3-8 part and Fructus Liquidambaris 18-22 part.
The Chinese medicine preparation of described treatment diabetic vascular neuropathy, the parts by weight of each crude drug are preferably: the Radix Astragali 20 parts, Ramulus Cinnamomi 10 parts, Radix Paeoniae Rubra 20 parts, Hirudo 5 parts, Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Squama Manis (processed) 5 parts and Fructus Liquidambaris 20 parts.
The Chinese medicine preparation of described treatment diabetic vascular neuropathy, can be prepared as decoction, powder, capsule or pill.
The preparation method of described decoction, comprises the following steps:
Step one, take the Radix Astragali, Ramulus Cinnamomi, Radix Paeoniae Rubra according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Hirudo, Radix Notoginseng, Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris, together put into container, add 500 1000 parts of water, be heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate I and filtering residue I, standby;
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300 500 parts of part water, be heated to boiling the most with high heat, then change slow fire into and boil 20 40 minutes, filter, obtain filtrate II, standby;
Step 3, by filtrate I and filtrate II mix homogeneously, i.e. prepare decoction.
Step one adds water 1000 parts, and slow fire boils 30min;Adding water 500 parts in step 2, slow fire boils 30min.
The preparation method of described powder, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, mix homogeneously, i.e. obtains powder.
The preparation method of described capsule, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, load No. 1 capsule after mix homogeneously, i.e. obtain capsule.
The usage of Chinese medicine preparation of this law invention treatment diabetic vascular neuropathy with consumption is: the dosage of the present invention depends on concrete dosage form, the factor such as the age of patient, body weight, health status.As guidance: the instructions of taking of decoction is, every day early, evening each oral once, each take 200-250mL, within 60 days, be a course for the treatment of;The instructions of taking of capsule is, each serving 43 times on the one, warm water is taken after mixing it with water, continuously treatment 2 months.
Herbal raw material medicine used by the present invention all can be buied from Chinese medicine shop, and its specification meets country's medical standards;Below in conjunction with embodiment, the present invention is further detailed.
Embodiment 1
A kind of Chinese medicine preparation treating diabetic vascular neuropathy, the Chinese medicine preparation of described treatment diabetic vascular neuropathy, the parts by weight of each crude drug are: the Radix Astragali 20 parts, Ramulus Cinnamomi 10 parts, Radix Paeoniae Rubra 20 parts, Hirudo 5 parts, Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Squama Manis (processed) 5 parts and Fructus Liquidambaris 20 parts.
The preparation method of described decoction, comprises the following steps:
Step one, take the Radix Astragali, Ramulus Cinnamomi, Radix Paeoniae Rubra according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Hirudo, Radix Notoginseng, Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris, together put into container, add 500 parts of water, be heated to boiling the most with high heat, then change slow fire into and boil 20 minutes, filter, obtain filtrate I and filtering residue I, standby;
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300 parts of part water, be heated to boiling the most with high heat, then change slow fire into and boil 20 minutes, filter, obtain filtrate II, standby;
Step 3, by filtrate I and filtrate II mix homogeneously, i.e. prepare decoction.
The preparation method of described powder, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, mix homogeneously, i.e. obtains powder.
The preparation method of described capsule, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, load No. 1 capsule after mix homogeneously, i.e. obtain capsule.
Embodiment 2
A kind of Chinese medicine preparation treating diabetic vascular neuropathy, the parts by weight of each crude drug are: the Radix Astragali 10 parts, Ramulus Cinnamomi 8 parts, Radix Paeoniae Rubra 15 parts, Hirudo 3 parts, Radix Notoginseng 8 parts, Radix Salviae Miltiorrhizae 10 parts, Squama Manis (processed) 3 parts and Fructus Liquidambaris 18 parts.
The preparation method of described decoction, comprises the following steps:
Step one, take the Radix Astragali, Ramulus Cinnamomi, Radix Paeoniae Rubra according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Hirudo, Radix Notoginseng, Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris, together put into container, add 1000 parts of water, be heated to boiling the most with high heat, then change slow fire into and boil 30 minutes, filter, obtain filtrate I and filtering residue I, standby;
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300 parts of part water, be heated to boiling the most with high heat, then change slow fire into and boil 20 minutes, filter, obtain filtrate II, standby;
Step 3, by filtrate I and filtrate II mix homogeneously, i.e. prepare decoction.
The preparation method of described powder, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, mix homogeneously, i.e. obtains powder.
The preparation method of described capsule, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, load No. 1 capsule after mix homogeneously, i.e. obtain capsule.
Embodiment 3
A kind of Chinese medicine preparation treating diabetic vascular neuropathy, the parts by weight of each crude drug are: the Chinese medicine preparation of described treatment diabetic vascular neuropathy, the parts by weight of each crude drug are preferably: the Radix Astragali 30 parts, Ramulus Cinnamomi 15 parts, Radix Paeoniae Rubra 25 parts, Hirudo 8 parts, Radix Notoginseng 15 parts, Radix Salviae Miltiorrhizae 18 parts, Squama Manis (processed) 8 parts and Fructus Liquidambaris 22 parts.
The preparation method of described decoction, comprises the following steps:
Step one, take the Radix Astragali, Ramulus Cinnamomi, Radix Paeoniae Rubra according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Hirudo, Radix Notoginseng, Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris, together put into container, add 800 parts of water, be heated to boiling the most with high heat, then change slow fire into and boil 30 minutes, filter, obtain filtrate I and filtering residue I, standby;
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 500 parts of part water, be heated to boiling the most with high heat, then change slow fire into and boil 40 minutes, filter, obtain filtrate II, standby;
Step 3, by filtrate I and filtrate II mix homogeneously, i.e. prepare decoction.
The preparation method of described powder, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, mix homogeneously, i.e. obtains powder.
The preparation method of described capsule, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, after Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, load No. 1 capsule after mix homogeneously, i.e. obtain capsule.
Clinical trial
1, experimental subject: be the patient of diabetic vascular neuropathy after diagnosing;Use the present invention to treat the Chinese medicine preparation of diabetic vascular neuropathy and treat case for many years as many as 800 examples, treat Patients with 300 Cases altogether as statistics;
2, Therapeutic Method: take Chinese medicine preparation decoction or capsule used by the present invention;The instructions of taking of decoction is, every day early, evening each oral once, each take 200-250mL, within 60 days, be a course for the treatment of;The instructions of taking of capsule is, each serving 43 times on the one, warm water is taken after mixing it with water, and within 60 days, is a course for the treatment of.
3, treatment evaluation criterion:
Effective: conscious numbness or pain symptom have improvement, occur during motion that lower limb are slightly uncomfortable and tranquillization ABI increases earlier above, the local vibrations threshold of feelings has improvement.
Effective: conscious numbness or pain symptom are obviously improved, occur without lower limb discomfort during motion and tranquillization ABI > 0.90, severe patient ABI improve more than 50% earlier above, the local vibrations threshold of feelings has clear improvement.
Invalid: subjective symptoms is without improving, and tranquillization ABI, the local vibrations threshold of feelings change without obvious before relatively treating.
4, therapeutic effect: the 300 example patients that the present invention is treated, the most effective 180 examples, effective 100, invalid 20 examples, treated effect reaches 93%.Result shows, Chinese medicine formula reasonable recipe of the present invention, evident in efficacy to treatment diabetic vascular neuropathy.
5, model case:
Medical record example 1
King so-and-so, female, hot spring people from village, hot spring town of 50 years old Ruzhou City, suffer from diabetes 6 years companion's lower limb intermittent claudication toes numb 1 year, look into extremity Doppler and show: ABI0.6, the double lower limb moderate neuropathy of local vibrations threshold of sensation 22V prompting;Lower limb vascular color ultrasound is shown: stricture of artery 70%, anterior tibial artery narrow 75%, is diagnosed as diabetes B lower limb nervus vasculairs pathological changes.Blood glucose fluctuation is controlled by oral antidiabetic drug.The Chinese medicine preparation complication of partner treatment diabetic vascular neuropathy.Take the Chinese medicinal capsule of the treatment diabetic vascular neuropathy of the present invention, each serving 43 times on the one, warm water is taken after mixing it with water, continuously treatment 2 months, and subjective symptoms is alleviated, and lower limb nerve affection inspection takes a turn for the better.
Medical record example 2
Lee so-and-so, man, 60 years old Dengfeng City great Jin people from shop, suffer from the 10 years merging left sufficient thumb pain of pedopathy of diabetes to fester, check and find lower limb vascular: stricture of artery 75%, anterior tibial artery narrow 80%, look into extremity Doppler to show: ABI0.5, the double lower limb moderate neuropathy of local vibrations threshold of sensation 24V prompting.Blood glucose fluctuation is controlled with insulin.Anti-infective therapy, conventional local changes dressings, and coordinates the present invention to treat the complication of Chinese medicine preparation treatment nervus vasculairs pathological changes of diabetic vascular neuropathy.Taking the present invention and treat the Chinese medicine preparation decoction of diabetic vascular neuropathy each serving 250 milliliters, 2 times on the one decoction being taken warmly, continuously treatment 2 months, conscious pain symptom alleviates, and foot ulcers heals.

Claims (7)

1. the Chinese medicine preparation treating diabetic vascular neuropathy, it is characterised in that: the parts by weight of each crude drug are: the Radix Astragali 20 parts, Ramulus Cinnamomi 10 parts, Radix Paeoniae Rubra 20 parts, Hirudo 5 parts, Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Squama Manis (processed) 5 parts and Fructus Liquidambaris 20 parts.
2. treat the Chinese medicine preparation of diabetic vascular neuropathy as claimed in claim 1, it is characterised in that: the parts by weight of each crude drug are: the Radix Astragali 20 parts, Ramulus Cinnamomi 10 parts, Radix Paeoniae Rubra 20 parts, Hirudo 5 parts, Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Squama Manis (processed) 5 parts and Fructus Liquidambaris 20 parts.
3. according to the Chinese medicine preparation treating diabetic vascular neuropathy described in claim 1 or 2, it is characterised in that: decoction, powder, capsule or pill can be prepared as.
4. as described in right 3, treat the Chinese medicine preparation of diabetic vascular neuropathy, it is characterised in that: the preparation method of described decoction, comprise the following steps:
Step one, take the Radix Astragali, Ramulus Cinnamomi, Radix Paeoniae Rubra according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Hirudo, Radix Notoginseng, Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris, together put into container, add 500-1000 part water, be heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate I and filtering residue I, standby;
Step 2, the filtering residue I obtained in step one is put into container, be subsequently adding 300-500 part part water, be heated to boiling the most with high heat, then change slow fire into and boil 20-40 minute, filter, obtain filtrate II, standby;
Step 3, by filtrate I and filtrate II mix homogeneously, i.e. prepare decoction.
5. as described in right 4, treat the Chinese medicine preparation of diabetic vascular neuropathy, it is characterised in that: step one adds water 1000 parts, and slow fire boils 30min;Adding water 500 parts in step 2, slow fire boils 30min.
6. as described in right 3, treat the Chinese medicine preparation of diabetic vascular neuropathy, it is characterised in that: the preparation method of described powder, comprise the following steps: take the Radix Astragali according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Ramulus Cinnamomi, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, Radix Salviae Miltiorrhizae, Squama Manis (processed) and Fructus Liquidambaris, after drying respectively, pulverize, mix homogeneously, i.e. obtains powder.
7. as described in right 3, treat the Chinese medicine preparation of diabetic vascular neuropathy, it is characterized in that: the preparation method of described capsule, comprise the following steps: take the Radix Astragali, Ramulus Cinnamomi according to the parts by weight of each crude drug of Chinese medicine preparation of described treatment diabetic vascular neuropathy, Radix Paeoniae Rubra, Hirudo, Radix Notoginseng, Radix Salviae Miltiorrhizae, after Squama Manis (processed) and Fructus Liquidambaris are dried respectively, pulverize, load No. 1 capsule after mix homogeneously, i.e. obtain capsule.
CN201610276195.1A 2016-04-29 2016-04-29 Traditional Chinese medicine preparation for treating diabetic neurovascular lesions Pending CN105748621A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101361821A (en) * 2008-10-10 2009-02-11 北京中医药大学 Medicine combination for treating diabetic peripheral neuropathy and preparation method thereof
CN103251697A (en) * 2012-02-21 2013-08-21 北京中医药大学 Medicinal composition for treating diabetic peripheral neuropathy, and preparation method thereof
CN104225221A (en) * 2014-08-12 2014-12-24 刘倩 Traditional Chinese medicine for treating diabetic peripheral neuropathy
CN105267559A (en) * 2015-11-06 2016-01-27 重庆市中药研究院 Diabetic peripheral neuropathy treatment medicine and manufacturing method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101361821A (en) * 2008-10-10 2009-02-11 北京中医药大学 Medicine combination for treating diabetic peripheral neuropathy and preparation method thereof
CN103251697A (en) * 2012-02-21 2013-08-21 北京中医药大学 Medicinal composition for treating diabetic peripheral neuropathy, and preparation method thereof
CN104225221A (en) * 2014-08-12 2014-12-24 刘倩 Traditional Chinese medicine for treating diabetic peripheral neuropathy
CN105267559A (en) * 2015-11-06 2016-01-27 重庆市中药研究院 Diabetic peripheral neuropathy treatment medicine and manufacturing method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陈红霞等: ""糖痹胶囊治疗气虚血瘀型糖尿病周围神经病变50例临床观察"", 《中医杂志》 *

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