CN105748536A - Wall-breaking oral traditional Chinese medicinal decoction piece and instant granular preparation and preparation method thereof - Google Patents
Wall-breaking oral traditional Chinese medicinal decoction piece and instant granular preparation and preparation method thereof Download PDFInfo
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- CN105748536A CN105748536A CN201610093141.1A CN201610093141A CN105748536A CN 105748536 A CN105748536 A CN 105748536A CN 201610093141 A CN201610093141 A CN 201610093141A CN 105748536 A CN105748536 A CN 105748536A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C21/00—Disintegrating plant with or without drying of the material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention provides wall-breaking oral traditional Chinese medicinal micronized powder and a preparation method thereof. The preparation method comprises the following steps of slicing fresh traditional Chinese medicine, crushing, and performing supercritical CO2 fluid infiltration and vibrating superfine grinding and polishing. Effective ingredients of a technical product provided by the invention are higher in content and good in stability; the amount of effective ingredients dissolved by the micronized powder is far greater than that dissolved by coarse powder and that of a medicinal extract.
Description
Technical field
The present invention relates to a kind of breaking cellular wall oral Chinese medicine decoction pieces and instant granular preparation and preparation method, a kind of breaking cellular wall oral Chinese medicine decoction pieces completed especially with institutional operation production procedure and instant granular preparation and preparation method, belong to prepared slices of Chinese crude drugs processing and Chinese medicine preparation production field.
Background technology
Chinese Medicine Industry is the national industry that China is traditional, is current fast-developing new industry, is again the important component part that shows unique characteristics of China's medication economics.There are some researches show, Chinese medicine has vast potential for future development, and the modernization of Chinese medicine is an up the important channel of Chinese Medicine Industry.The various changes of current international and domestic medical market and the development trend of 21 century medical market, while bringing the opportunity of a lifetime to Chinese Medicine Industry, also form stern challenge.
Tradition decoction feature be carry inconvenience, decoct time-consuming, decocting method is lack of standardization, quality is uncontrollable, directly affects therapeutic effect.It is possible not only to carry out preferably quality control making prepared slices of Chinese crude drugs instant granular after single medicinal material Preparation process, decoction, concentration, and more environmentally-friendly, health, portable, and patient also saves decocting time.Many bags of granules are put in cup and are taken after mixing it with water by patient together, it is also possible to obtain the curative effect that the fried prepared slices of Chinese crude drugs are the same.
Multiple Chinese herbal medicine is carried out reasonably combined, and adds sweeting agent based on oligosaccharide, size-reduced, homogenizing, dry and make popular peculiar flavour instant tea powder.The Chinese herbal medicine adopted has heat-clearing and toxic substances removing, damp eliminating, the health-care effects such as pathogenic fire reducing of relieving summer heat, Sorbitol, maltose alcohol have low-yield, dental caries, improve gastrointestinal function, and oligosaccharide has the health-care effects such as high efficiently multiplying bacillus bifidus, loosening bowel to relieve constipation, dispelling toxicity, detoxicating, raising immunity, blood fat reducing.Instant-drink, and health, adapt to the allegro living needs of people's Modern high throughput.
Summary of the invention
The purpose of the present invention overcomes above-mentioned deficiency exactly, it is provided that a kind of solve to carry inconvenience, decoct time-consuming, decocting method is lack of standardization, quality is uncontrollable, directly affects product and the method for the shortcomings such as therapeutic effect.Study through lot of experiments, it is determined that every amount of water of taste medicine, intensification boiling time, decoction number of times；The extracting method of lower kind volatile oil, additional proportion after optimization；Select suitable impurity removal process；Grope the drying process with atomizing of heterogeneity kind；Develop the granulating process etc. being substantially not added with under adjuvant premise；The difficult points such as the anti-moisture absorption technique of Chinese medicine instant granular extractum, multi items filtering technique, drying process with atomizing are captured.
The present invention is achieved in that
A kind of breaking cellular wall Chinese medicine ultra-fine powder, it is characterised in that it is the powder prepared in the following manner: by fresh Chinese medicine section, pulverize, then put it into containing supercritical CO2In the basin of fluid, in basin, temperature is-25-0 DEG C, and force (forcing) pump is promoted to 40-50MPa supercritical CO2Quality 1-3 times of Chinese medicine pulverized particles, supercritical CO20.5-1 times of alcohol solvent of entrainer, pretreatment 5-15min, by aperture 10cm, solution flow rate 1.5-3.0ml/min, pressure 20-30MPa nozzle, pretreatment with Chinese medicine coarse powder is sent into vibration type micronizing and grinds in mixing roll, 1.5MPa, charging rate is 4kg/h-8kg/h, at-20 DEG C to-0 DEG C of temperature, carry out micronizing, obtain Chinese medicine ultra-fine powder product；The grain diameter of described Chinese medicine ultra-fine powder is less than 10 μm；Described grinding time is 3-4min.
The preparation method of a kind of breaking cellular wall Chinese medicine ultra-fine powder, it is characterised in that the method step is as follows: by fresh Chinese medicine section, pulverize, then put it into containing supercritical CO2In the basin of fluid, in basin, temperature is-25-0 DEG C, and force (forcing) pump is promoted to 40-50MPa supercritical CO2Quality 1-3 times of Chinese medicine pulverized particles, supercritical CO20.5-1 times of alcohol solvent of entrainer, pretreatment 5-15min, by aperture 10cm, solution flow rate 1.5-3.0ml/min, pressure 20-30MPa nozzle, pretreatment with Chinese medicine coarse powder is sent into vibration type micronizing and grinds in mixing roll, 1.5MPa, charging rate is 4kg/h-8kg/h, at-20 DEG C to-0 DEG C of temperature, carry out micronizing, obtain Chinese medicine ultra-fine powder product；The grain diameter of described Chinese medicine ultra-fine powder is less than 10 μm；Described grinding time is 3-4min.
The present invention is to solve the defect that in the product that the existing prepared slices of Chinese crude drugs are concocted or processing and treating method obtains, its active constituent content is not high, it is provided that a kind of active constituent content is higher, the prepared slices of Chinese crude drugs superfine powder of good stability.The invention has the beneficial effects as follows: the product of the present invention breaches the conventional thought of existing technique, fresh for belt leather Chinese medicine is processed, verified by many experiments, the content of its effective ingredient is higher, good stability, and the amount of prepared slices of Chinese crude drugs superfine powder its effective ingredient of dissolution of the present invention is much larger than the amount of the amount of coarse powder dissolution, medical material extractum.
Explain below by design parameter, technical scheme is described in further detail.Should be appreciated that the enforcement of the present invention is not limited to following concrete kind, any pro forma accommodation and/or change that the present invention is made fall within scope.
In the present invention, if not refering in particular to, all of part, percentage ratio are unit of weight, and all of equipment and raw material etc. all can be buied from market or the industry is conventional.
Data below is the prepared slices of Chinese crude drugs superfine powder detection data adopting this technique to obtain
Note: data above is all according to one the related request inspection of 2010 Chinese Pharmacopoeia.
It should be noted that this process program is an integrated artistic, change the change reducing this technological process or parameter by directly affecting the active constituent content ratio of Chinese medicine ultra-fine powder, mean particle dia, dissolution and every consumption per day.
If changing 0.5-1 times of alcohol solvent parameter of entrainer, calculate active constituent content percent data entire lowering nearly 10% by dry product；If charging rate is 4kg/h-8kg/h parameter grain diameter reaches less than 10 μm quantity than decline 8%；If it is little to increase the change of grinding time 3-4min parameter whole result, but power consumption significantly improves；If pressure 20-30MPa Nozzle Parameter changes grain diameter reaches less than 10 μm quantity than decline 5%；If force (forcing) pump is promoted to 40-50MPa supercritical CO2Quality 1-3 times of Chinese medicine is pulverized particle parameter change and is pressed dry product calculating active constituent content percent data entire lowering nearly 7%；And the change of data above directly affects dosage and the curative effect of medicine.
Detailed description of the invention
The preparation of embodiment 1 breaking cellular wall Chinese medicine Cortex Moutan superfine powder
1, preparation method
By fresh Chinese medicine Cortex Moutan section, it is crushed to below 1cm, then puts it into containing supercritical CO2In the basin of fluid, in basin, temperature is-25-0 DEG C, and force (forcing) pump is promoted to 40-50MPa supercritical CO2Quality 1-3 times of Cortex Moutan pulverized particles, supercritical CO20.5-1 times of alcohol solvent of entrainer, pretreatment 5-15min, by aperture 10cm, solution flow rate 1.5-3.0ml/min, pressure 20-30MPa nozzle, Cortex Moutan pretreatment coarse powder is sent into vibration type micronizing and grinds in mixing roll, 1.5MPa, charging rate is 4kg/h-8kg/h, at-20 DEG C to-0 DEG C of temperature, carry out micronizing, obtain Chinese medicine Cortex Moutan superfine powder product；Grinding time is 3-4min.
By fresh Chinese medicine Cortex Moutan section, it is crushed to below 1cm, then puts it into containing supercritical CO2In the basin of fluid, in basin, temperature is-25-0 DEG C, and force (forcing) pump is promoted to 40-50MPa supercritical CO2Quality 1-3 times of Cortex Moutan pulverized particles, supercritical CO20.5-1 times of alcohol solvent of entrainer, pretreatment 5-15min, by aperture 10cm, solution flow rate 1.5-3.0ml/min, pressure 20-30MPa nozzle, Cortex Moutan pretreatment coarse powder is sent into vibration type micronizing and grinds in mixing roll, 1.5MPa, charging rate is 4kg/h-8kg/h, at-20 DEG C to-0 DEG C of temperature, carry out micronizing, obtain Cortex Moutan superfine powder product；The grain diameter of the Chinese medicine Cortex Moutan superfine powder of gained is less than 5 μm；Grinding time is 3-4min.
By fresh Chinese medicine Cortex Moutan section, it is crushed to below 1cm, then puts it into containing supercritical CO2In the basin of fluid, in basin, temperature is-25 DEG C, and force (forcing) pump is promoted to 40MPa supercritical CO21 times of Cortex Moutan pulverized particles of quality, supercritical CO20.5 times of alcohol solvent of entrainer, pretreatment 5min, by aperture 10cm, solution flow rate 1.5ml/min, pressure 20MPa nozzle, Cortex Moutan pretreatment coarse powder is sent into vibration type micronizing and grinds in mixing roll, 1.5MPa, charging rate is 4kg/h, at-20 DEG C of temperature, carry out micronizing, obtain Chinese medicine Cortex Moutan superfine powder product；Grinding time is 3min.
By fresh Chinese medicine Cortex Moutan section, it is crushed to below 1cm, then puts it into containing supercritical CO2In the basin of fluid, in basin, temperature is 0 DEG C, and force (forcing) pump is promoted to 50MPa supercritical CO23 times of Cortex Moutan pulverized particles of quality, supercritical CO21 times of alcohol solvent of entrainer, pretreatment 15min, by aperture 10cm, solution flow rate 3.0ml/min, pressure 30MPa nozzle, Cortex Moutan pretreatment coarse powder is sent into vibration type micronizing and grinds in mixing roll, 1.5MPa, charging rate is 8kg/h, at 0 DEG C of temperature, carry out micronizing, obtain Chinese medicine Cortex Moutan superfine powder product；Grinding time is 4min.
By fresh Chinese medicine Cortex Moutan section, it is crushed to below 1cm, then puts it into containing supercritical CO2In the basin of fluid, in basin, temperature is-15 DEG C, and force (forcing) pump is promoted to 45MPa supercritical CO22 times of Cortex Moutan pulverized particles of quality, supercritical CO20.7 times of alcohol solvent of entrainer, pretreatment 8min, by aperture 10cm, solution flow rate 2.0ml/min, pressure 25MPa nozzle, Cortex Moutan pretreatment coarse powder is sent into vibration type micronizing and grinds in mixing roll, 1.5MPa, charging rate is 6kg/h, at-10 DEG C of temperature, carry out micronizing, obtain Chinese medicine Cortex Moutan superfine powder product；Grinding time is 3min.
2, inspection
Adopt WQL particle size analyzer determination particle size distribution, three groups of experimental results: grain diameter reaches less than 10 μm quantity and accounts for percentage ratio 96.13%, 96.52%, 96.41%.Crude drug cell substantially completely crushes.
Superfine powder In Vitro Dissolution test in 10 minutes, measures dissolution rate, three groups of experimental results: 96.92%, 97.12%, 97.01% according to the method in one Cortex Moutan high-efficient liquid phase technique of 2010 Chinese Pharmacopoeia.
Active constituent content measuring, measures according to the method in one Cortex Moutan high-efficient liquid phase technique of 2010 Chinese Pharmacopoeia, and methodology examination is qualified, system suitability is qualified.Three groups of experiment effective ingredient paeonol contents are 2.71%, 2.80%, 2.75%.
The present invention measures dry Cortex Moutan superfine powder content by HPLC method, dissolution is above common process product, so quantity reduces nearly 1/2.
Claims (2)
1. a breaking cellular wall Chinese medicine ultra-fine powder, it is characterised in that it is the powder prepared in the following manner: by fresh Chinese medicine section, pulverize, then put it into containing supercritical CO2In the basin of fluid, in basin, temperature is-25-0 DEG C, and force (forcing) pump is promoted to 40-50MPa supercritical CO2Quality 1-3 times of Chinese medicine pulverized particles, supercritical CO20.5-1 times of alcohol solvent of entrainer, pretreatment 5-15min, by aperture 10cm, solution flow rate 1.5-3.0ml/min, pressure 20-30MPa nozzle, pretreatment with Chinese medicine coarse powder is sent into vibration type micronizing and grinds in mixing roll, 1.5MPa, charging rate is 4kg/h-8kg/h, at-20 DEG C to-0 DEG C of temperature, carry out micronizing, obtain Chinese medicine ultra-fine powder product；The grain diameter of described Chinese medicine ultra-fine powder is less than 10 μm；Described grinding time is 3-4min.
2. the preparation method of a breaking cellular wall Chinese medicine ultra-fine powder, it is characterised in that the method step is as follows: by fresh Chinese medicine section, pulverize, then put it into containing supercritical CO2In the basin of fluid, in basin, temperature is-25-0 DEG C, and force (forcing) pump is promoted to 40-50MPa supercritical CO2Quality 1-3 times of Chinese medicine pulverized particles, supercritical CO20.5-1 times of alcohol solvent of entrainer, pretreatment 5-15min, by aperture 10cm, solution flow rate 1.5-3.0ml/min, pressure 20-30MPa nozzle, pretreatment with Chinese medicine coarse powder is sent into vibration type micronizing and grinds in mixing roll, 1.5MPa, charging rate is 4kg/h-8kg/h, at-20 DEG C to-0 DEG C of temperature, carry out micronizing, obtain Chinese medicine ultra-fine powder product；The grain diameter of described Chinese medicine ultra-fine powder is less than 10 μm；Described grinding time is 3-4min.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212340A (en) * | 2013-04-07 | 2013-07-24 | 中国计量科学研究院 | Supercritical fluid extracting, spraying and granulating system and method |
| CN104946383A (en) * | 2015-04-30 | 2015-09-30 | 江苏江大源生态生物科技有限公司 | Method for preparing ganoderma lucidum spores oil through supercritical CO2 composite microwave-assisted extraction |
| CN105232584A (en) * | 2015-09-30 | 2016-01-13 | 河南行知专利服务有限公司 | Decoction-free extraction process for precious Chinese herbal medicines |
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- 2016-02-21 CN CN201610093141.1A patent/CN105748536A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212340A (en) * | 2013-04-07 | 2013-07-24 | 中国计量科学研究院 | Supercritical fluid extracting, spraying and granulating system and method |
| CN104946383A (en) * | 2015-04-30 | 2015-09-30 | 江苏江大源生态生物科技有限公司 | Method for preparing ganoderma lucidum spores oil through supercritical CO2 composite microwave-assisted extraction |
| CN105232584A (en) * | 2015-09-30 | 2016-01-13 | 河南行知专利服务有限公司 | Decoction-free extraction process for precious Chinese herbal medicines |
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