CN105124080A - Pseudo-ginseng tea and preparation method thereof - Google Patents
Pseudo-ginseng tea and preparation method thereof Download PDFInfo
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- CN105124080A CN105124080A CN201510675408.3A CN201510675408A CN105124080A CN 105124080 A CN105124080 A CN 105124080A CN 201510675408 A CN201510675408 A CN 201510675408A CN 105124080 A CN105124080 A CN 105124080A
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Abstract
The invention belongs to the field of Chinese herbal medicine health-care products and particularly relates to pseudo-ginseng tea and a preparation method thereof. The pseudo-ginseng tea is prepared from, by weight, 10-100 parts of pseudo-ginseng and 10-100 parts of gynura procumbens. The preparation method of the pseudo-ginseng tea comprises the steps of raw material preparation, preliminary pulverization, carbon dioxide supercritical extraction, nanometer pulverization, wall-breaking pulverization and mixing. According to the pseudo-ginseng tea and the preparation method thereof, pseudo-ginseng and gynura procumbens serve as raw materials, pharmacology serves as the basis, the extraction is conducted by the adoption of the synergistic and appropriate steps and parameters, and therefore the optimum effective ingredients of the raw materials can be retained; the pseudo-ginseng tea has the advantages that human body blood vessels can be unchoked, waste metabolite in a human body can be removed, the microcirculation can be improved, the human body metabolism can be protected, arteriosclerosis can be prevented and treated, the blood pressure can be lowered, blood sugar can be decreased, and the immunity can be enhanced.
Description
Technical field
The invention belongs to traditional Chinese medicine health care product field, be specifically related to a kind of notoginseng tea and preparation method thereof.
Background technology
Pseudo-ginseng has another name called pseudo-ginseng, mountain paint, radix notoginseng etc., and be araliaceae ginseng plant, the Latin of pseudo-ginseng is called Panaxnotoginseng (Burk) F.H.Chen; The famous pharmacy man Li Shizhen (1518-1593 A.D.) of the Ming Dynasty claims (invaluable); Pseudo-ginseng is a jewel in Chinese medicine, records in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying the first, pseudo-ginseng enriches blood the first, taste with and merit also etc., therefore claiming Panax pseudoginseng, is the most precious person in Chinese medicine." pseudo-ginseng has strengthening by means of tonics, promoting blood circulation and removing blood stasis, the effects such as swelling and pain relieving.Arasaponin is the effective active composition extracted from Chinese medicine pseudo-ginseng, and cardiovascular system is had to cardiac stimulant, coronary artery dilator, increase coronary blood flow, antiatherosclerosis, reduction surface activity of blood platelet, suppresses platelet activation, sticks and assemble, reduces the effect such as blood viscosity, antithrombus formation; To cerebrovascular ischemia anoxia-induced apoptosis, cerebral ischemia re-pouring injuredly there is protective effect, have inhibitory action to cranial nerve cell apoptosis.Gynura procumbens (Lour.) Merr, be composite family pseudo-ginseng platymiscium, Latin is called Gynuraprocumbens (Lour) morr, is perennial herb medicine food dual purpose plant.Gynura procumbens (Lour.) Merr has function that is clearing and activating the channels and collaterals, eliminating stasis to subdue swelling, all has good curative effect for cardiovascular and cerebrovascular disease, hypertension, diabetes.
At present, in traditional Chinese medicine health care product field, not yet occur simultaneously with pseudo-ginseng and Gynura procumbens (Lour.) Merr for raw material, instant effect, easily to absorb, have no side effect, can long-term taking, there is notoginseng tea that is hypotensive, hypoglycemic, develop immunitypty function.
Summary of the invention
The invention provides a kind of preparation method of notoginseng tea, bulk drug pseudo-ginseng is carried out carbon dioxide supercritical extraction process by the method, then pulverizes as nano particle, obtains this notoginseng tea.
The present invention is achieved by the following technical solutions:
A kind of notoginseng tea, its raw material comprises: pseudo-ginseng 10-100 weight portion, Gynura procumbens (Lour.) Merr 10-100 weight portion.
Above-mentioned notoginseng tea preferred embodiment in, also comprise in its raw material: gynostemma pentaphylla 10-100 weight portion, STEVIA REBAUDIANA 10-100 weight portion.
The present invention is realized by another technical scheme following:
A preparation method for notoginseng tea, comprises the following steps:
Raw material preparation process: choose pseudo-ginseng and carry out cleaning treatment, then by clean pseudo-ginseng in carrying out drying and processing, obtain dry pseudo-ginseng; Choose Gynura procumbens (Lour.) Merr, carry out cleaning treatment, more clean Gynura procumbens (Lour.) Merr is carried out drying and processing, obtain dry Gynura procumbens (Lour.) Merr;
Primary comminution process: the pseudo-ginseng of described drying and dry Gynura procumbens (Lour.) Merr are carried out primary comminution process with pulverizer respectively, obtains pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal respectively;
Carbon dioxide supercritical extraction step: get pseudo-ginseng corase meal described in Part I, Gynura procumbens (Lour.) Merr corase meal, carry out carbon dioxide supercritical extraction process respectively, obtains pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract respectively;
Nanometer pulverization step: described pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract are carried out vacuum drying treatment, obtains the dry cream of pseudo-ginseng and the dry cream of Gynura procumbens (Lour.) Merr respectively; Respectively dry for described pseudo-ginseng cream, the dry cream of Gynura procumbens (Lour.) Merr are carried out nanometer pulverization process again, obtain the sleeping chrysanthemum Radix Notoginseng nanopowder end of Radix Notoginseng nanopowder end peace;
Broken wall pulverising step: described pseudo-ginseng corase meal, the Gynura procumbens (Lour.) Merr corase meal of getting remainder, first carries out first broken wall pulverization process respectively, obtains pseudo-ginseng first broken wall powder, Gynura procumbens (Lour.) Merr first broken wall powder; Again described pseudo-ginseng first broken wall powder, Gynura procumbens (Lour.) Merr first broken wall powder are carried out second broken wall pulverization process respectively, obtain pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder;
Blend step: by described Radix Notoginseng nanopowder end, Gynura procumbens (Lour.) Merr nanometer powder, pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, carry out mixed processing, obtain described notoginseng tea after mixing.
The preparation method of above-mentioned notoginseng tea preferred embodiment in, in described raw material preparation process, in the described drying and processing of pseudo-ginseng, temperature is 40-60 DEG C, and the time is 0.5-5h, in the described drying and processing of Gynura procumbens (Lour.) Merr, temperature is 30-40, and the time is 0.5-3h.
The preparation method of above-mentioned notoginseng tea preferred embodiment in, in described primary comminution process, the average grain diameter of described pseudo-ginseng corase meal and Gynura procumbens (Lour.) Merr corase meal is 0.1-0.5mm.
The preparation method of above-mentioned notoginseng tea preferred embodiment in, in described carbon dioxide supercritical extraction step, the pseudo-ginseng corase meal of described Part I is the 30-80% of the gross weight of described pseudo-ginseng corase meal, and the Gynura procumbens (Lour.) Merr corase meal of described Part I is the 30-80% of the gross weight of described Gynura procumbens (Lour.) Merr corase meal.
The preparation method of above-mentioned notoginseng tea preferred embodiment in, in described carbon dioxide supercritical extraction step, for described pseudo-ginseng corase meal, the parameter of described carbon dioxide supercritical extraction process is: extracting pressure is 30-50Mpa, extraction temperature is 30-50 DEG C, and separator pressure is 15-30Mpa, and separator temperature is 40-60 DEG C, disengaging time is 2-6h, and carbon dioxide flow is 30-60L/h; For Gynura procumbens (Lour.) Merr corase meal, the parameter of described carbon dioxide supercritical extraction process is: extracting pressure is 40-50Mpa, and extraction temperature is 40-50 DEG C, separator pressure is 20-30Mpa, separator temperature is 40-50 DEG C, and disengaging time is 2-6h, and carbon dioxide flow is 30-60L/h.
The preparation method of above-mentioned notoginseng tea preferred embodiment in, in described nanometer pulverization step, the temperature of described vacuum drying treatment is 40-60 DEG C.
The preparation method of above-mentioned notoginseng tea preferred embodiment in, in described nanometer pulverization step, the average grain diameter at the sleeping chrysanthemum Radix Notoginseng nanopowder end of peace, described Radix Notoginseng nanopowder end is 100-500nm.
The preparation method of above-mentioned notoginseng tea preferred embodiment in, in described broken wall pulverising step, the average grain diameter of described pseudo-ginseng first broken wall powder, Gynura procumbens (Lour.) Merr first broken wall powder is 1-5 μm; Preferably, the average grain diameter of described pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder is 100-500nm.
Compared to existing technology, beneficial effect of the present invention is:
1, the present invention is using the sleeping chrysanthemum of pseudo-ginseng peace as raw material, based on pharmacology, adopts mutually synergistic, suitable step and parameter to extract, so can retain the best active ingredient of raw material.
2, a part for bulk drug adopts carbon dioxide supercritical extraction to be extracted liquid by the present invention, then pulverizes as nanometer powder, is suitable for the separation of heat-sensitive substance, readily oxidizable substance, volatile substances, is conducive to the reservation of active ingredient; Another part of bulk drug adopts broken wall to pulverize and obtains broken wall powder, effectively can discharge whole elite of bulk drug, thus strengthen its suction-operated, and then strengthen its curative effect; The raw material nanometer powder conbined usage that above-mentioned two kinds of different disposal obtain, synergy, is conducive to the quality and the curative effect that improve notoginseng tea product.
3, the present invention has instant effect, easily absorbs, and has no side effect, the feature of energy long-term taking; The present invention has can dredge human vas, purged body intracellular metabolite refuse, improve microcirculation, the metabolism of protection body, prevent and treat effect of artery sclerosis, hypotensive, hypoglycemic, develop immunitypty.
Detailed description of the invention
A kind of notoginseng tea, raw material comprises: pseudo-ginseng and Gynura procumbens (Lour.) Merr, and the weight ratio of the two is (10-100): (10-100); Exemplarily, the weight ratio of the two can be 10:100,100:10,50:75,30:85 etc.
The preparation method of above-mentioned notoginseng tea, comprises the following steps:
Step one, raw material prepare: choose disease-free, more than 3 years pseudo-ginseng clip (preferred Yunnan, the place of production), carry out cleaning treatment, more clean pseudo-ginseng is carried out drying and processing 0.5-5h in 40-60 DEG C, obtain dry pseudo-ginseng;
Choose stem and the leaf of disease-free Gynura procumbens (Lour.) Merr, carry out cleaning treatment, more clean Gynura procumbens (Lour.) Merr is carried out drying and processing 0.5-3h in 30-40 DEG C, obtain dry Gynura procumbens (Lour.) Merr.
Exemplarily, the bake out temperature of above-mentioned pseudo-ginseng can be arbitrary value in 40 DEG C, 45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C or scope therebetween arbitrarily, and drying time can be arbitrary value in 0.5h, 1h, 3h, 5h or any scope therebetween; The bake out temperature of above-mentioned Gynura procumbens (Lour.) Merr can be arbitrary value in 30 DEG C, 32 DEG C, 35 DEG C, 38 DEG C, 40 DEG C or scope therebetween arbitrarily, and drying time can be arbitrary value in 0.5h, 1h, 1.5h, 2h, 2.5h, 3h or any scope therebetween.
Step 2, primary comminution: the Gynura procumbens (Lour.) Merr of the pseudo-ginseng of this drying and this drying is carried out primary comminution process with pulverizer respectively, obtain pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal respectively, average grain diameter is 0.1-0.5mm (such as, can be arbitrary value in 0.1mm, 0.2mm, 0.3mm, 0.4mm, 0.5mm or scope therebetween arbitrarily).
Step 3, extraction: get and account for respective gross weight 30-80% (such as, can be arbitrary value in 30%, 40%, 50%, 60%, 70%, 80% or scope therebetween arbitrarily) pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal, carry out carbon dioxide supercritical extraction process respectively, obtain pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract respectively;
For pseudo-ginseng corase meal, the parameter of above carbon dioxide supercritical extraction process is: extracting pressure is 30-50Mpa, and extraction temperature is 30-50 DEG C, separator pressure is 15-30Mpa, separator temperature is 40-60 DEG C, and disengaging time is 2-6h, and carbon dioxide flow is 30-60L/h;
For Gynura procumbens (Lour.) Merr corase meal, the parameter of above carbon dioxide supercritical extraction process is: extracting pressure is 40-50Mpa, and extraction temperature is 40-50 DEG C, separator pressure is 20-30Mpa, separator temperature is 40-50 DEG C, and disengaging time is 2-6h, and carbon dioxide flow is 30-60L/h.
Exemplarily, for in the carbon dioxide supercritical extraction process of pseudo-ginseng corase meal, extracting pressure can be 30Mpa, 35Mpa, 40Mpa, 45Mpa, arbitrary value in 50Mpa or any scope therebetween, extraction temperature can be 30 DEG C, 35 DEG C, 40 DEG C, 45 DEG C, arbitrary value in 50 DEG C or any scope therebetween, separator pressure can be 15Mpa, 18Mpa, 20Mpa, 25Mpa, arbitrary value in 30Mpa or any scope therebetween, separator temperature can be 40 DEG C, 45 DEG C, 50 DEG C, 55 DEG C, arbitrary value in 60 DEG C or any scope therebetween, disengaging time can be 2h, 3h, 4h, 5h, arbitrary value in 6h or any scope therebetween, carbon dioxide flow can be 30L/h, 40L/h, 45L/h, 50L/h, arbitrary value in 60L/h or any scope therebetween,
Exemplarily, for in the carbon dioxide supercritical extraction process of Gynura procumbens (Lour.) Merr corase meal, extracting pressure can be 40Mpa, 42Mpa, 45Mpa, 47Mpa, arbitrary value in 50Mpa or any scope therebetween, extraction temperature can be 40 DEG C, 42 DEG C, 45 DEG C, 48 DEG C, arbitrary value in 50 DEG C or any scope therebetween, separator pressure can be 20Mpa, 23Mpa, 25Mpa, 28Mpa, arbitrary value in 30Mpa or any scope therebetween, separator temperature can be 40 DEG C, 42 DEG C, 45 DEG C, 48 DEG C, arbitrary value in 50 DEG C or any scope therebetween, disengaging time can be 2h, 3h, 4h, 5h, arbitrary value in 6h or any scope therebetween, carbon dioxide flow can be 30L/h, 40L/h, 45L/h, 50L/h, arbitrary value in 60L/h or any scope therebetween.
Step 4, nanometer pulverization: first respectively by this pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract in 40-60 DEG C (such as, can be the arbitrary value in 40 DEG C, 45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C or any scope therebetween) carry out vacuum drying treatment, obtain the dry cream of pseudo-ginseng and the dry cream of Gynura procumbens (Lour.) Merr respectively; High energy nanometer electuary mill is utilized to carry out nanometer pulverization process dry for pseudo-ginseng cream, the dry cream of Gynura procumbens (Lour.) Merr respectively again, obtain the sleeping chrysanthemum Radix Notoginseng nanopowder end of Radix Notoginseng nanopowder end peace that average grain diameter is 100-500nm (such as, can be arbitrary value in 100nm, 150nm, 200nm, 300nm, 400nm, 500nm or scope therebetween arbitrarily).
Step 5, broken wall are pulverized: get pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal that remaining step 2 is obtained, first carry out first broken wall pulverization process respectively in air screening pulverizer, obtain pseudo-ginseng first broken wall powder, Gynura procumbens (Lour.) Merr first broken wall powder, its average grain diameter is 1-5 μm (such as, can be arbitrary value in 1 μm, 2 μm, 2.5 μm, 3 μm, 4 μm, 5 μm or scope therebetween arbitrarily); Again by pseudo-ginseng first broken wall powder, Gynura procumbens (Lour.) Merr first broken wall powder respectively at carrying out second broken wall pulverization process in low temperature planetary ball mill, obtain pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, its average grain diameter is 100-500nm (such as, can be arbitrary value in 100nm, 150nm, 200nm, 300nm, 400nm, 500nm or scope therebetween arbitrarily).
Step 6, mixing: get above-mentioned Radix Notoginseng nanopowder end, Gynura procumbens (Lour.) Merr nanometer powder, pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, in batch mixer, carry out mixed processing, after mixing, obtain mixed-powder, be notoginseng tea; Can check after the pack of this mixed-powder, store, sell.
Above-mentioned steps three-four and step 5 both can be carried out simultaneously, also can successively carry out.In above-mentioned steps three, carbon dioxide supercritical extraction process, is suitable for the separation of heat-sensitive substance, readily oxidizable substance, volatile substances, is conducive to the reservation of active ingredient; In above-mentioned steps five, broken wall is pulverized effectively can discharge the whole elite of bulk drug, thus strengthens its suction-operated, and then strengthens its curative effect; Respectively through the raw material nanometer powder conbined usage that two kinds of different disposal obtain, be conducive to the quality and the curative effect that improve notoginseng tea product.
In the raw material of above-mentioned notoginseng tea, other parts of generic medicinal plants can also be comprised, such as: gynostemma pentaphylla 10-100 weight portion, STEVIA REBAUDIANA 10-100 weight portion etc.; In the preparation method of this notoginseng tea, the operation of step one-four, see above, prepares the sleeping chrysanthemum Radix Notoginseng nanopowder end of Radix Notoginseng nanopowder end peace; In step 5, to need other bulk drug also through twice broken wall pulverization process, successively obtain respective average grain diameter be 1-5 μm first broken wall powder peace all particle diameter be the broken wall powder of 100-500nm, afterwards all powder are mixed.
Above-mentioned notoginseng tea has following functions effect:
The effect of cardiovascular and cerebrovascular: can coronary flow be increased, improve microcirculation, adjustment myocardial ischemia-anoxemia state.Promote fibrinolytic, suppress artery sclerosis.
Hematological system effect: can shorten the clotting time, promotes that fibrin ferment generates, shrinks local vascular, can suppress platelet aggregation while increasing platelet counts.Stimulate circulation, prevent thrombosis.
Antiinflammatory action: suppress vasopermeability, excited Pituitary Adrenalcortical system, elevate plasma concentration of cortisol.Excite the phagocytic activity of macrophage, strengthen the comprehensive toxin ability of immunoglobulin (Ig).
Immunity moderation effect: too high or too low immune response can be made to recover normal, do not disturb the normal immunoreaction of normal body.
Metabolism: can promote that serum proteins synthesize, promotes liver dna synthesis.
Anti-aging effects: elevate plasma albumin, to protein, nucleic acid, hormone, immunity has a certain impact and regulates.Promote the acquisition of memory, consolidate and reproduce.
Antitumor action: can ultra-oxygen anion free radical be removed.To HL-60 cell to while ripe neutrophil differentiation, the synthesis of cell DNA and RNA can be affected.
Other effects: promote the spleen lymphocyte hyperplasia after 60-Co-r damage, there is radiation resistance.Certain antagonism is had with Nimodipine is similar.Acute ischemia renal failure can be prevented with verapamil is similar.There is certain Hemorrhagic shock, anti-stress effect.
Above-mentioned notoginseng tea function cures mainly: clearing heat and detoxicating, benefiting stomach and stopping pain, eliminating stasis to subdue swelling.Auxiliary curative effect is had to constipation, insomnia, obesity, diabetes, coronary heart diseases and angina pectoris.
The proterties of above-mentioned notoginseng tea is: sweet, the micro-hardship of taste, warm in nature.
Instructions of taking of the present invention is: once a day, each 2g, drinks after soaking 20 minutes with 200ml boiling water, can Instant Drinks continuously, and morning, clothes were best.
In the chemical composition of above-mentioned notoginseng tea, containing number of chemical compositions such as notoginsenoside, dimercyanidin, flavonoid glycoside, cupreol, amino acid, polysaccharide, starch, volatile oil, alkaloid, organic acids.
This notoginseng tea is based on the pharmacology of pseudo-ginseng and Gynura procumbens (Lour.) Merr, with the theory that homeostasis balances again, retain the best active ingredient of raw material, thus develop pure natural, green, nuisanceless notoginseng tea, this notoginseng tea has instant effect, easily absorbs, and has no side effect, can hypotensive, hypoglycemic, develop immunitypty, can the feature of long-term taking.
Embodiment 1:
The notoginseng tea of the present embodiment, raw material comprises: pseudo-ginseng 10 weight portion, Gynura procumbens (Lour.) Merr 90 weight portion.
The preparation method of above-mentioned notoginseng tea, comprises the following steps:
(1) raw material prepares (cleaning and oven dry): choose disease-free, more than 3 years pseudo-ginseng clip (being preferably Yunnan, the place of production), clean up, then carry out drying and processing 4h in 40 DEG C, obtain dry pseudo-ginseng;
Choose stem and the leaf of disease-free Gynura procumbens (Lour.) Merr, clean up, then carry out drying and processing 3h in 40 DEG C, obtain dry Gynura procumbens (Lour.) Merr.
(2) primary comminution: the Gynura procumbens (Lour.) Merr of the pseudo-ginseng of this drying and this drying is carried out primary comminution process with pulverizer respectively, and obtain pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal respectively, average grain diameter is 0.3mm.
(3) carbon dioxide supercritical extraction extraction: get and account for pseudo-ginseng corase meal, the Gynura procumbens (Lour.) Merr corase meal that respective gross weight is 60%, adopts carbon dioxide supercritical extraction equipment respectively, carries out carbon dioxide supercritical extraction;
Wherein, the parameter of the carbon dioxide supercritical extraction process of pseudo-ginseng corase meal is: extracting pressure is 50Mpa, and extraction temperature is 30 DEG C, and separator pressure is 15Mpa, and separator temperature is 40 DEG C, and disengaging time is 6h, and carbon dioxide flow is 60L/h; Obtain pseudo-ginseng extract;
The parameter of the carbon dioxide supercritical extraction process of Gynura procumbens (Lour.) Merr corase meal is: extracting pressure is 40Mpa, and extraction temperature is 50 DEG C, and separator pressure is 20Mpa, and separator temperature is 40 DEG C, and disengaging time is 6h, and carbon dioxide flow is 30/h; Obtain Gynura procumbens (Lour.) Merr extract.
(4) nanometer pulverization: first respectively this pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract are carried out vacuum drying treatment in 40 DEG C, obtains the dry cream of pseudo-ginseng and the dry cream of Gynura procumbens (Lour.) Merr respectively; Utilize high energy nanometer electuary mill to carry out nanometer pulverization process dry for pseudo-ginseng cream, the dry cream of Gynura procumbens (Lour.) Merr respectively again, obtain the sleeping chrysanthemum Radix Notoginseng nanopowder end of Radix Notoginseng nanopowder end peace that average grain diameter is 300nm.
(5) broken wall is pulverized: get pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal that remaining step (2) is obtained, first carry out first broken wall pulverization process respectively in air screening pulverizer, obtain the sleeping chrysanthemum pseudo-ginseng first broken wall powder of pseudo-ginseng first broken wall powder peace that average grain diameter is 2 μm; Again by above-mentioned two kinds of powder respectively at carrying out second broken wall pulverization process in low temperature planetary ball mill, obtain pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, its average grain diameter is 400nm.
(6) mix: get above-mentioned Radix Notoginseng nanopowder end, Gynura procumbens (Lour.) Merr nanometer powder, pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, in batch mixer, carry out mixed processing, after mixing, obtain mixed-powder, be notoginseng tea; Can check after the pack of this mixed-powder, store, sell.
The notoginseng tea of the present embodiment has effect that is hypotensive, hypoglycemic, develop immunitypty, and result of the test is as follows.
1, hypotensive:
In order to check the hypotensive effect of the notoginseng tea of the present embodiment, carry out animal experiment.
Test method: select SHR (SH) rat 50, be divided into 2 groups, often organize each 25;
Wherein, test group: on the basis of mouse grain and water, every morning feeding the present embodiment the tea (tea bag of notoginseng tea is immersed in the water, till color is no longer deepened by notoginseng tea 4g, water 20g) that brews of notoginseng tea; Control group: mouse grain and drinking-water are only provided.Duration of test, measures blood pressure (SBP) every afternoon.
Result is: after taking 3d, and the blood pressure of test group reduces 20-30mmHg compared with the blood pressure of control group; The hypotensive activity of notoginseng tea clearly.
2, hypoglycemic:
In order to check the hypoglycemic effect of the notoginseng tea of the present embodiment, carry out clinical testing.
Test method: choose 50 routine type ii diabetes volunteers for subjects, wherein man 26 example, female 24 example, mean age 35-39 year; Average medical history is 2-3.
Conveniently clinical testing want summation approach, tea (notoginseng tea 10g, water 50g that the notoginseng tea taking the present embodiment brews, the tea bag of notoginseng tea is immersed in the water, till the color of tea is no longer deepened) take 2 months continuously, every day 3 times, take before the meal.Take between this gleocystic stage, other hypoglycemic drugs are stopped using.
Blood sugar decreasing effect computational methods are to reduce the percentage calculation of blood glucose value (mmol/L): blood sugar reduces percentage=[(take front blood glucose value-take rear blood glucose value)/take front blood glucose value] × 100%.
Result is: take notoginseng tea 1 month, and the insulin level of (on an empty stomach) and 2h after the meal reduces 12.5-26.5% and 27.5-45.5% respectively before the meal; The hypoglycemic activity of notoginseng tea clearly.
3, develop immunitypty:
In order to check the effect of the develop immunitypty of the notoginseng tea of the present embodiment, carry out animal experiment.
Test method:
Test method: select female mice 100, body weight 18-22g, be divided into 2 groups, often organizes 50; Wherein, test group: on the basis of mouse grain and water, every morning feeding the present embodiment the tea (tea bag of notoginseng tea is immersed in the water by notoginseng tea 4g, water 20g, till the color of tea is no longer deepened) that brews of notoginseng tea; Control group: mouse grain and drinking-water are only provided.
Continuous feeding, after 30 days, carries out mouse hemolytic plaque test respectively, macrophage phagocytic chicken Lactoferrin test in mouse peritoneal, the mouse cell SPL competence for added value test of ConA induction.
Result is: control group of comparing, and the mouse hemolysis plaque number of test group increases, and phagocytic percentage and the phagocytic index of engulfing chicken red blood cell all raise, and the mouse lymphocyte multiplication capacity of ConA induction all increases, and all has significant difference; The successful of notoginseng tea develop immunitypty.
Embodiment 2:
The notoginseng tea of the present embodiment, raw material comprises: pseudo-ginseng 50 weight portion, Gynura procumbens (Lour.) Merr 50 weight portion.
The preparation method of above-mentioned notoginseng tea, comprises the following steps:
(1) raw material prepares (cleaning and oven dry): choose disease-free, more than 3 years pseudo-ginseng clip (being preferably Yunnan, the place of production), clean up, then carry out drying and processing 3h in 50 DEG C, obtain dry pseudo-ginseng;
Choose stem and the leaf of disease-free Gynura procumbens (Lour.) Merr, clean up, then carry out drying and processing 0.5h in 40 DEG C, obtain dry Gynura procumbens (Lour.) Merr.
(2) primary comminution: the Gynura procumbens (Lour.) Merr of the pseudo-ginseng of this drying and this drying is carried out primary comminution process with pulverizer respectively, and obtain pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal respectively, average grain diameter is 0.2mm.
(3) carbon dioxide supercritical extraction extraction: get and account for pseudo-ginseng corase meal, the Gynura procumbens (Lour.) Merr corase meal that respective gross weight is 50%, adopts carbon dioxide supercritical extraction equipment respectively, carries out carbon dioxide supercritical extraction;
Wherein, the parameter of the carbon dioxide supercritical extraction process of pseudo-ginseng corase meal is: extracting pressure is 35Mpa, and extraction temperature is 45 DEG C, and separator pressure is 20Mpa, and separator temperature is 50 DEG C, and disengaging time is 4h, and carbon dioxide flow is 30L/h; Obtain pseudo-ginseng extract;
The parameter of the carbon dioxide supercritical extraction process of Gynura procumbens (Lour.) Merr corase meal is: extracting pressure is 45Mpa, and extraction temperature is 45 DEG C, and separator pressure is 30Mpa, and separator temperature is 50 DEG C, and disengaging time is 2h, and carbon dioxide flow is 60/h; Obtain Gynura procumbens (Lour.) Merr extract.
(4) nanometer pulverization: first respectively this pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract are carried out vacuum drying treatment in 50 DEG C, obtains the dry cream of pseudo-ginseng and the dry cream of Gynura procumbens (Lour.) Merr respectively; Utilize high energy nanometer electuary mill to carry out nanometer pulverization process dry for pseudo-ginseng cream, the dry cream of Gynura procumbens (Lour.) Merr respectively again, obtain the sleeping chrysanthemum Radix Notoginseng nanopowder end of Radix Notoginseng nanopowder end peace that average grain diameter is 500nm.
(5) broken wall is pulverized: get pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal that remaining step (2) is obtained, first carry out first broken wall pulverization process respectively in air screening pulverizer, obtain the sleeping chrysanthemum pseudo-ginseng first broken wall powder of pseudo-ginseng first broken wall powder peace that average grain diameter is 4 μm; Again by above-mentioned two kinds of powder respectively at carrying out second broken wall pulverization process in low temperature planetary ball mill, obtain pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, its average grain diameter is 300nm.
(6) mix: get above-mentioned Radix Notoginseng nanopowder end, Gynura procumbens (Lour.) Merr nanometer powder, pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, in batch mixer, carry out mixed processing, after mixing, obtain mixed-powder, be notoginseng tea; Can check after the pack of this mixed-powder, store, sell.
Carry out animal experiment or clinical testing according to the method for embodiment 1, result of the test can prove that the notoginseng tea of the present embodiment has effect that is hypotensive, hypoglycemic, develop immunitypty.
Embodiment 3:
The notoginseng tea of the present embodiment, raw material comprises: pseudo-ginseng 90 weight portion, Gynura procumbens (Lour.) Merr 20 weight portion.
The preparation method of above-mentioned notoginseng tea, comprises the following steps:
(1) raw material prepares (cleaning and oven dry): choose disease-free, more than 3 years pseudo-ginseng clip (being preferably Yunnan, the place of production), clean up, then carry out drying and processing 1h in 60 DEG C, obtain dry pseudo-ginseng;
Choose stem and the leaf of disease-free Gynura procumbens (Lour.) Merr, clean up, then carry out drying and processing 2h in 35 DEG C, obtain dry Gynura procumbens (Lour.) Merr.
(2) primary comminution: the Gynura procumbens (Lour.) Merr of the pseudo-ginseng of this drying and this drying is carried out primary comminution process with pulverizer respectively, and obtain pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal respectively, average grain diameter is 0.1mm.
(3) carbon dioxide supercritical extraction extraction: get and account for pseudo-ginseng corase meal, the Gynura procumbens (Lour.) Merr corase meal that respective gross weight is 80%, adopts carbon dioxide supercritical extraction equipment respectively, carries out carbon dioxide supercritical extraction;
Wherein, the parameter of the carbon dioxide supercritical extraction process of pseudo-ginseng corase meal is: extracting pressure is 30Mpa, and extraction temperature is 50 DEG C, and separator pressure is 25Mpa, and separator temperature is 45 DEG C, and disengaging time is 4h, and carbon dioxide flow is 50L/h; Obtain pseudo-ginseng extract;
The parameter of the carbon dioxide supercritical extraction process of Gynura procumbens (Lour.) Merr corase meal is: extracting pressure is 50Mpa, and extraction temperature is 40 DEG C, and separator pressure is 25Mpa, and separator temperature is 45 DEG C, and disengaging time is 2h, and carbon dioxide flow is 60/h; Obtain Gynura procumbens (Lour.) Merr extract.
(4) nanometer pulverization: first respectively this pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract are carried out vacuum drying treatment in 60 DEG C, obtains the dry cream of pseudo-ginseng and the dry cream of Gynura procumbens (Lour.) Merr respectively; Utilize high energy nanometer electuary mill to carry out nanometer pulverization process dry for pseudo-ginseng cream, the dry cream of Gynura procumbens (Lour.) Merr respectively again, obtain the sleeping chrysanthemum Radix Notoginseng nanopowder end of Radix Notoginseng nanopowder end peace that average grain diameter is 200nm.
(5) broken wall is pulverized: get pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal that remaining step (2) is obtained, first carry out first broken wall pulverization process respectively in air screening pulverizer, obtain the sleeping chrysanthemum pseudo-ginseng first broken wall powder of pseudo-ginseng first broken wall powder peace that average grain diameter is 5 μm; Again by above-mentioned two kinds of powder respectively at carrying out second broken wall pulverization process in low temperature planetary ball mill, obtain pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, its average grain diameter is 200nm.
(6) mix: get above-mentioned Radix Notoginseng nanopowder end, Gynura procumbens (Lour.) Merr nanometer powder, pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, in batch mixer, carry out mixed processing, after mixing, obtain mixed-powder, be notoginseng tea; Can check after the pack of this mixed-powder, store, sell.
Carry out animal experiment or clinical testing according to the method for embodiment 1, result of the test can prove that the notoginseng tea of the present embodiment has effect that is hypotensive, hypoglycemic, develop immunitypty.
Embodiment 4:
The notoginseng tea of the present embodiment, raw material comprises: pseudo-ginseng 30 weight portion, Gynura procumbens (Lour.) Merr 70 weight portion.
The preparation method of above-mentioned notoginseng tea, comprises the following steps:
(1) raw material prepares (cleaning and oven dry): choose disease-free, more than 3 years pseudo-ginseng clip (being preferably Yunnan, the place of production), clean up, then carry out drying and processing 5h in 45 DEG C, obtain dry pseudo-ginseng;
Choose stem and the leaf of disease-free Gynura procumbens (Lour.) Merr, clean up, then carry out drying and processing 2.5h in 32 DEG C, obtain dry Gynura procumbens (Lour.) Merr.
(2) primary comminution: the Gynura procumbens (Lour.) Merr of the pseudo-ginseng of this drying and this drying is carried out primary comminution process with pulverizer respectively, and obtain pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal respectively, average grain diameter is 0.5mm.
(3) carbon dioxide supercritical extraction extraction: get and account for pseudo-ginseng corase meal, the Gynura procumbens (Lour.) Merr corase meal that respective gross weight is 30%, adopts carbon dioxide supercritical extraction equipment respectively, carries out carbon dioxide supercritical extraction;
Wherein, the parameter of the carbon dioxide supercritical extraction process of pseudo-ginseng corase meal is: extracting pressure is 42Mpa, and extraction temperature is 45 DEG C, and separator pressure is 30Mpa, and separator temperature is 60 DEG C, and disengaging time is 3.5h, and carbon dioxide flow is 45L/h; Obtain pseudo-ginseng extract;
The parameter of the carbon dioxide supercritical extraction process of Gynura procumbens (Lour.) Merr corase meal is: extracting pressure is 48Mpa, and extraction temperature is 42 DEG C, and separator pressure is 22Mpa, and separator temperature is 47 DEG C, and disengaging time is 5h, and carbon dioxide flow is 40/h; Obtain Gynura procumbens (Lour.) Merr extract.
(4) nanometer pulverization: first respectively this pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract are carried out vacuum drying treatment in 55 DEG C, obtains the dry cream of pseudo-ginseng and the dry cream of Gynura procumbens (Lour.) Merr respectively; Utilize high energy nanometer electuary mill to carry out nanometer pulverization process dry for pseudo-ginseng cream, the dry cream of Gynura procumbens (Lour.) Merr respectively again, obtain the sleeping chrysanthemum Radix Notoginseng nanopowder end of Radix Notoginseng nanopowder end peace that average grain diameter is 400nm.
(5) broken wall is pulverized: get pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal that remaining step (2) is obtained, first carry out first broken wall pulverization process respectively in air screening pulverizer, obtain the sleeping chrysanthemum pseudo-ginseng first broken wall powder of pseudo-ginseng first broken wall powder peace that average grain diameter is 3 μm; Again by above-mentioned two kinds of powder respectively at carrying out second broken wall pulverization process in low temperature planetary ball mill, obtain pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, its average grain diameter is 500nm.
(6) mix: get above-mentioned Radix Notoginseng nanopowder end, Gynura procumbens (Lour.) Merr nanometer powder, pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, in batch mixer, carry out mixed processing, after mixing, obtain mixed-powder, be notoginseng tea; Can check after the pack of this mixed-powder, store, sell.
Carry out animal experiment or clinical testing according to the method for embodiment 1, result of the test can prove that the notoginseng tea of the present embodiment has effect that is hypotensive, hypoglycemic, develop immunitypty.
Claims (10)
1. a notoginseng tea, is characterized in that:
The raw material of described notoginseng tea comprises: pseudo-ginseng 10-100 weight portion, Gynura procumbens (Lour.) Merr 10-100 weight portion.
2. notoginseng tea according to claim 1, is characterized in that:
Also comprise in the raw material of described notoginseng tea: gynostemma pentaphylla 10-100 weight portion, STEVIA REBAUDIANA 10-100 weight portion.
3. the preparation method of notoginseng tea according to claim 1, is characterized in that: described preparation method comprises the following steps:
Raw material preparation process: choose pseudo-ginseng and carry out cleaning treatment, then by clean pseudo-ginseng in carrying out drying and processing, obtain dry pseudo-ginseng; Choose Gynura procumbens (Lour.) Merr, carry out cleaning treatment, more clean Gynura procumbens (Lour.) Merr is carried out drying and processing, obtain dry Gynura procumbens (Lour.) Merr;
Primary comminution process: the pseudo-ginseng of described drying and dry Gynura procumbens (Lour.) Merr are carried out primary comminution process with pulverizer respectively, obtains pseudo-ginseng corase meal, Gynura procumbens (Lour.) Merr corase meal respectively;
Carbon dioxide supercritical extraction step: get pseudo-ginseng corase meal described in Part I, Gynura procumbens (Lour.) Merr corase meal, carry out carbon dioxide supercritical extraction process respectively, obtains pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract respectively;
Nanometer pulverization step: described pseudo-ginseng extract, Gynura procumbens (Lour.) Merr extract are carried out vacuum drying treatment, obtains the dry cream of pseudo-ginseng and the dry cream of Gynura procumbens (Lour.) Merr respectively; Respectively dry for described pseudo-ginseng cream, the dry cream of Gynura procumbens (Lour.) Merr are carried out nanometer pulverization process again, obtain the sleeping chrysanthemum Radix Notoginseng nanopowder end of Radix Notoginseng nanopowder end peace;
Broken wall pulverising step: described pseudo-ginseng corase meal, the Gynura procumbens (Lour.) Merr corase meal of getting remainder, first carries out first broken wall pulverization process respectively, obtains pseudo-ginseng first broken wall powder, Gynura procumbens (Lour.) Merr first broken wall powder; Again described pseudo-ginseng first broken wall powder, Gynura procumbens (Lour.) Merr first broken wall powder are carried out second broken wall pulverization process respectively, obtain pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder;
Blend step: by described Radix Notoginseng nanopowder end, Gynura procumbens (Lour.) Merr nanometer powder, pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder, carry out mixed processing, obtain described notoginseng tea after mixing.
4. the preparation method of notoginseng tea according to claim 3, is characterized in that:
In described raw material preparation process, in the described drying and processing of pseudo-ginseng, temperature is 40-60 DEG C, and the time is 0.5-5h, and in the described drying and processing of Gynura procumbens (Lour.) Merr, temperature is 30-40, and the time is 0.5-3h.
5. the preparation method of notoginseng tea according to claim 3, is characterized in that:
In described primary comminution process, the average grain diameter of described pseudo-ginseng corase meal and Gynura procumbens (Lour.) Merr corase meal is 0.1-0.5mm.
6. the preparation method of notoginseng tea according to claim 3, is characterized in that:
In described carbon dioxide supercritical extraction step, the pseudo-ginseng corase meal of described Part I is the 30-80% of the gross weight of described pseudo-ginseng corase meal, and the Gynura procumbens (Lour.) Merr corase meal of described Part I is the 30-80% of the gross weight of described Gynura procumbens (Lour.) Merr corase meal.
7. the preparation method of notoginseng tea according to claim 3 or 6, is characterized in that:
In described carbon dioxide supercritical extraction step, for described pseudo-ginseng corase meal, the parameter of described carbon dioxide supercritical extraction process is: extracting pressure is 30-50Mpa, extraction temperature is 30-50 DEG C, separator pressure is 15-30Mpa, separator temperature is 40-60 DEG C, and disengaging time is 2-6h, and carbon dioxide flow is 30-60L/h; For Gynura procumbens (Lour.) Merr corase meal, the parameter of described carbon dioxide supercritical extraction process is: extracting pressure is 40-50Mpa, and extraction temperature is 40-50 DEG C, separator pressure is 20-30Mpa, separator temperature is 40-50 DEG C, and disengaging time is 2-6h, and carbon dioxide flow is 30-60L/h.
8. the preparation method of notoginseng tea according to claim 3, is characterized in that:
In described nanometer pulverization step, the temperature of described vacuum drying treatment is 40-60 DEG C.
9. the preparation method of notoginseng tea according to claim 3 or 8, is characterized in that:
In described nanometer pulverization step, the average grain diameter at the sleeping chrysanthemum Radix Notoginseng nanopowder end of peace, described Radix Notoginseng nanopowder end is 100-500nm.
10. the preparation method of notoginseng tea according to claim 3, is characterized in that:
In described broken wall pulverising step, the average grain diameter of described pseudo-ginseng first broken wall powder, Gynura procumbens (Lour.) Merr first broken wall powder is 1-5 μm;
Preferably, the average grain diameter of described pseudo-ginseng broken wall powder, Gynura procumbens (Lour.) Merr broken wall powder is 100-500nm.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105511507A (en) * | 2015-12-11 | 2016-04-20 | 苏州泽达兴邦医药科技有限公司 | Traditional Chinese medicine percolation process liquid level stability control method |
| CN106819271A (en) * | 2016-12-12 | 2017-06-13 | 哈尔滨灵丹鸿运茶品有限公司 | A kind of burdock notoginseng tea and preparation method thereof |
| CN106922894A (en) * | 2015-12-30 | 2017-07-07 | 北京万源普达医疗科技有限公司 | A kind of Gynura procumbens (Lour.) Merr tea and preparation method thereof |
| CN108432920A (en) * | 2018-03-30 | 2018-08-24 | 赵建华 | A kind of compound tea and preparation method thereof |
| WO2019106967A1 (en) * | 2017-11-30 | 2019-06-06 | 佳人 鳥居 | Method for manufacturing immune activation agent and method for manufacturing immune activation food/drink |
| TWI728324B (en) * | 2019-03-12 | 2021-05-21 | 鳥居佳人 | Method for producing immune activation agent, method for producing food and drink for immune activation, and medicine |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1156692A (en) * | 1996-11-28 | 1997-08-13 | 黄传贵 | Ginsenoside drinking water |
| CN103156108A (en) * | 2013-04-02 | 2013-06-19 | 曾晓飞 | Fortified food for preventing and treating diabetes mellitus and hypertension diseases |
| CN104585404A (en) * | 2013-11-03 | 2015-05-06 | 汪礼洋 | Mount Song wild unprepared fleece-flower root powder for prolonging life |
-
2015
- 2015-10-15 CN CN201510675408.3A patent/CN105124080A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1156692A (en) * | 1996-11-28 | 1997-08-13 | 黄传贵 | Ginsenoside drinking water |
| CN103156108A (en) * | 2013-04-02 | 2013-06-19 | 曾晓飞 | Fortified food for preventing and treating diabetes mellitus and hypertension diseases |
| CN104585404A (en) * | 2013-11-03 | 2015-05-06 | 汪礼洋 | Mount Song wild unprepared fleece-flower root powder for prolonging life |
Non-Patent Citations (1)
| Title |
|---|
| 郑国栋等: "平卧菊三七对小鼠血糖及血脂的影响", 《现代食品科技》 * |
Cited By (9)
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|---|---|---|---|---|
| CN105511507A (en) * | 2015-12-11 | 2016-04-20 | 苏州泽达兴邦医药科技有限公司 | Traditional Chinese medicine percolation process liquid level stability control method |
| CN106922894A (en) * | 2015-12-30 | 2017-07-07 | 北京万源普达医疗科技有限公司 | A kind of Gynura procumbens (Lour.) Merr tea and preparation method thereof |
| CN106819271A (en) * | 2016-12-12 | 2017-06-13 | 哈尔滨灵丹鸿运茶品有限公司 | A kind of burdock notoginseng tea and preparation method thereof |
| WO2019106967A1 (en) * | 2017-11-30 | 2019-06-06 | 佳人 鳥居 | Method for manufacturing immune activation agent and method for manufacturing immune activation food/drink |
| JP2019099477A (en) * | 2017-11-30 | 2019-06-24 | 佳人 鳥居 | Method for producing immunostimulatory agent and method for producing food and drink for immune activation |
| CN110300524A (en) * | 2017-11-30 | 2019-10-01 | 鸟居佳人 | The manufacturing method of immune activation agent and the manufacturing method of immune activation diet product |
| US11064721B2 (en) * | 2017-11-30 | 2021-07-20 | Kazuhito Tore | Method for producing immune activator and method for producing food and drink for immune activation |
| CN108432920A (en) * | 2018-03-30 | 2018-08-24 | 赵建华 | A kind of compound tea and preparation method thereof |
| TWI728324B (en) * | 2019-03-12 | 2021-05-21 | 鳥居佳人 | Method for producing immune activation agent, method for producing food and drink for immune activation, and medicine |
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Application publication date: 20151209 |