CN1057452C - Sperm-producing pill - Google Patents
Sperm-producing pill Download PDFInfo
- Publication number
- CN1057452C CN1057452C CN95113767.0A CN95113767A CN1057452C CN 1057452 C CN1057452 C CN 1057452C CN 95113767 A CN95113767 A CN 95113767A CN 1057452 C CN1057452 C CN 1057452C
- Authority
- CN
- China
- Prior art keywords
- radix ginseng
- semen
- powder
- pellet
- sperm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000006187 pill Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 claims abstract description 27
- 239000002775 capsule Substances 0.000 claims abstract description 14
- 208000007466 Male Infertility Diseases 0.000 claims abstract description 12
- 210000000582 semen Anatomy 0.000 claims description 15
- 239000008188 pellet Substances 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 13
- 241000208340 Araliaceae Species 0.000 claims description 12
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 12
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 12
- 235000008434 ginseng Nutrition 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- 229930182470 glycoside Natural products 0.000 claims description 9
- 150000002338 glycosides Chemical class 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- 238000011026 diafiltration Methods 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 235000005903 Dioscorea Nutrition 0.000 claims description 2
- 241000234273 Dioscorea Species 0.000 claims description 2
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 2
- 206010013786 Dry skin Diseases 0.000 claims description 2
- 235000004879 dioscorea Nutrition 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims description 2
- 239000012567 medical material Substances 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 239000003208 petroleum Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 235000002789 Panax ginseng Nutrition 0.000 abstract description 3
- 210000003056 antler Anatomy 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 241000208688 Eucommia Species 0.000 abstract 1
- 244000017020 Ipomoea batatas Species 0.000 abstract 1
- 235000002678 Ipomoea batatas Nutrition 0.000 abstract 1
- 235000017784 Mespilus germanica Nutrition 0.000 abstract 1
- 244000182216 Mimusops elengi Species 0.000 abstract 1
- 235000000560 Mimusops elengi Nutrition 0.000 abstract 1
- 241000157491 Morinda Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 235000007837 Vangueria infausta Nutrition 0.000 abstract 1
- 235000017524 noni Nutrition 0.000 abstract 1
- 230000000920 spermatogeneic effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 230000021595 spermatogenesis Effects 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
- 206010021929 Infertility male Diseases 0.000 description 1
- 206010003883 azoospermia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention takes pure traditional Chinese medicines of pilose antler, red ginseng, prepared rhizome of rehmannia, sweet potato, medlar, eucommia bark, morinda root and the like as basic formulas, and prepares a traditional Chinese medicine capsule, namely spermatogenic pill, for mainly treating male infertility through scientific processing. The medicine can fully exert the characteristics of traditional Chinese medicine decoction in clinic, and has obvious curative effect on male infertility symptoms such as low sperm amount, no sperm or low normal sperm morphology.
Description
Content of the present invention belongs to the preparation technology field of medicine, relates to a kind of pellet for generation of semen Chinese medicine and preparation technology thereof who is used for the treatment of male infertility.
The shared large percentage of male infertility in the clinical outpatient service of infertility shows and can reach more than 35% according to relevant statistics at present.Though it is the reason of male sterility is many, clinical low or the azoospermia attitude more sees that this type of patient accounts for male infertility patient's about 80% with sperm quantity deficiency, eupyrene sperm form.With regard to treatment, though also once there were many media to disclose some (partially) sides now from the tonifying YANG angle of Chinese medicine, they also have certain curative effect in some aspects to the treatment male infertility, but generally speaking the clinical cure rate of these prescriptions is lower, and the prescription that has in use also has toxic and side effects to the patient.In addition, up to now, the effective typing medicine that this area does not still have treatment sperm quality defective class male infertility comes out.
The objective of the invention is to overcome the deficiency of state of the art, provide a kind of prescription science, easy to prepare, curative effect is high, have no side effect be exclusively used in treatment male infertility pure Chinese medicinal preparation---the pellet for generation of semen of sperm quality defective class male infertility particularly.
Pellet for generation of semen Chinese medicine of the present invention be the invention designer by medicine and pharmacology book is at all times concentrated on studies and on clinical practice basis for many years concentrated the summary develop acquisition, the Therapeutic Principle that it fills out marrow according to relevant kidney and spleen invigorating, beneficial essence in motherland's traditional medicine, with pure Chinese medicines such as Cornu Cervi Pantotrichum, Radix Ginseng Rubra, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Lycii, the Cortex Eucommiae, Ba Ji is basic recipe, through science processing, make capsule.This medicine can be given full play to the characteristics of Chinese medicine decoct in clinical practice, few, no sperm of sperm or the low inferior symptom of eupyrene sperm form are all had obvious curative effects, is the ideal medicament of present this area treatment male infertility.
The basic recipe composition (percentage by weight) that constitutes this pellet for generation of semen Chinese medicinal capsule is:
Cornu Cervi Pantotrichum 5～10% Radix Ginseng Rubra 10～15%
Radix Rehmanniae Preparata 15～20% Rhizoma Dioscoreaes 15～20%
Fructus Lycii 15～20% Cortexs Eucommiae 10～15%
Crust halberd 10～15%.Cornu Cervi Pantotrichum, the Cortex Eucommiae, crust halberd all belong to sweet using warming therapy product in the prescription, and the kind temperature of merit is separated kidney yang, strong muscles and bones, and modern pharmacological research shows that also they all have excited human body sexual function and promote gonepoietic effect; Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Lycii property are all gentle, are the product of enrich and benefit essence and blood, nourishing the liver and kidney; Radix Ginseng has temperature to separate the merit of kidney spleen, spermatogenesis benefit marrow, and has the effect that promotes the gonad function, stimulates spermatogenesis.Above-mentioned all medicines share, and logical benefit combination, effect are concentrated one's efforts grand, can reach the purpose of the kidney invigorating, spleen invigorating, spermatogenesis benefit marrow in the shorter course of treatment.
Below in conjunction with accompanying drawing behind the literary composition the capsular preparation method of pellet for generation of semen of the present invention is illustrated.
Fig. 1 is a pellet for generation of semen preparation technology flow chart.
Fig. 2 extracts the flow chart of thick general glycoside technical process for Radix Ginseng Rubra among Fig. 1.
Referring to accompanying drawing, the preparation method of this pellet for generation of semen capsule comprises following preparation process:
1. clean all medicines of prescription;
2. pilose antler is pulverized 100 mesh sieves, got velvet powder;
3. red ginseng extracts thick general glycoside, and this leaching process is undertaken by the preparation process that Fig. 2 provides,
A) adopt the benzinum reflux technique that the ginseng meal is prepared as dewaxing root meal,
B) utilize 75～90 ethanol that dewaxing root meal is carried out diafiltration, get percolate,
C) solvent (ethanol) in the recovered under reduced pressure percolate, and the percolate residue is dissolved in water adds the chloroform-ethanolic solution that mixes by 2: 1 amounts simultaneously in residue liquid, extract then the diafiltration mixed liquor to carrying most glucoside,
D) chloroform layer after the extraction is carried out reduced pressure concentration and reclaim, get the thick general glycoside of red ginseng;
4. the distilled water that Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Lycii, the Cortex Eucommiae, crust halberd is added six times of amounts boils and extracted 2 hours, filters extracting solution and deposits in addition, and the distilled water that the medicine residual liquid is added four times of amounts again boils and extracted 1 hour then; Extracted twice liquid is converted is closed, and will convert and close liquid to be concentrated into medical material content in 60～80 ℃ of temperature be 1: 1～1.5, concentrated solution;
5. velvet powder, thick Radix Ginseng Rubra general glycoside are added in the concentrated solution after last preparation process, stirring is placed in the drying baker, at 60～80 ℃ of temperature inner dryings, pulverizes 100 mesh sieves then, gets the pellet for generation of semen fine drug powder;
6. the fine drug powder branch is packed in " 0 " number capsule and capsule subpackage is gone in the finished product medicine bottle, every capsule includes medicated powder 0.4 gram, and every bottle includes 60 of capsules;
7. labeling, packing.
Case observation and curative effect:
1, medicining mode: every day 3 times, each 5 capsules, 28 is a course of treatment.
2, criterion of therapeutical effect: recovery from illness---sperm quantity reaches more than 6,000 ten thousand/ml, and the sperm normal morphology is higher than 60%.Invalid---sperm quantity is lower than 6,000 ten thousand/ml, and the sperm normal morphology is lower than 60%.
3, observation of curative effect: the present invention is in development process, and clinical case history 69 examples of observing are altogether wherein cured 68 examples, invalid 1 example, and total effective rate is 97.4%.The patient take behind this capsule conscious energetic, sleep, libido strengthens.To because of routine index of semen low former thereby cause sterile for many years after marriage man (age is between 25～50 years old, lover is normal fertility), after taking the pellet for generation of semen treatment, indexs such as patient's sperm count, motility of sperm all are significantly increased, most of just very fast pregnancy of its lover after treating 1～3 course of treatment.
Claims (3)
1, a kind of pellet for generation of semen Chinese medicine that is used for the treatment of male infertility is characterized in that it is to be made by following raw materials by weight percent:
Cornu Cervi Pantotrichum 5～10% Radix Ginseng Rubra 10～15%
Radix Rehmanniae Preparata 15～20% Rhizoma Dioscoreaes 15～20%
Fructus Lycii 15～20% Cortexs Eucommiae 10～15%
Crust halberd 10～15%.
2, a kind of method for preparing the described pellet for generation of semen Chinese medicine of claim 1 is characterized in that comprising following preparation process:
2.1 clean all medicines of prescription;
2.2 Cornu Cervi Pantotrichum was pulverized 100 mesh sieves, got velvet powder;
2.3 Radix Ginseng Rubra extracts thick general glycoside;
2.4 the distilled water that Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Lycii, the Cortex Eucommiae, crust halberd are added six times of amounts boils and extracted 2 hours, filters extracting solution and deposits in addition, the distilled water that the medicine residual liquid is added four times of amounts again boils and extracted 1 hour then; Extracted twice liquid is converted is closed, and will convert and close liquid to be concentrated into medical material content in 60～80 ℃ of temperature be 1: 1～1.5, concentrated solution;
2.5 in velvet powder, the concentrated solution of thick Radix Ginseng Rubra general glycoside adding after 2.4 processes, stirring is placed in the drying baker, at 60～80 ℃ of temperature inner dryings, pulverizes 100 mesh sieves then, gets the pellet for generation of semen fine drug powder;
2.6 pack into the fine drug powder branch in " 0 " number capsule and capsule subpackage is gone in the finished product medicine bottle, every capsule includes medicated powder 0.4 gram, and every bottle includes 60 of capsules;
2.7 labeling, packing.
3, the method for preparing pellet for generation of semen Chinese medicine as claimed in claim 2 is characterized in that described Radix Ginseng Rubra extracts thick general glycoside process and undertaken by following preparation process:
3.1 adopt the petroleum ether reflux technique that the Radix Ginseng coarse powder is prepared as dewaxing root coarse powder;
3.2 utilize 75～90 ethanol that dewaxing root coarse powder is carried out diafiltration, get percolate;
3.3 solvent ethanol in the reclaim under reduced pressure percolate, and the percolate residue is dissolved in water, in residue liquid, add simultaneously by 2: 1 blended chloroform-alcoholic solution of amount, extract the diafiltration mixed liquor then to carrying most glycoside;
Reclaim 3.4 the chloroform layer after the extraction is carried out concentrating under reduced pressure, get thick Radix Ginseng Rubra general glycoside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95113767.0A CN1057452C (en) | 1995-10-25 | 1995-10-25 | Sperm-producing pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95113767.0A CN1057452C (en) | 1995-10-25 | 1995-10-25 | Sperm-producing pill |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1148961A CN1148961A (en) | 1997-05-07 |
| CN1057452C true CN1057452C (en) | 2000-10-18 |
Family
ID=5080082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95113767.0A Expired - Fee Related CN1057452C (en) | 1995-10-25 | 1995-10-25 | Sperm-producing pill |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1057452C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1108808C (en) * | 1997-12-25 | 2003-05-21 | 李运乃 | Medicinal powder for treatment of deferent duct stagnation and obstruction |
| CN1085093C (en) * | 1998-07-16 | 2002-05-22 | 张代表 | Traditional Chinese medicine oral liquor for treating male infertility |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083710A (en) * | 1992-12-29 | 1994-03-16 | 南勋义 | Compound capsule for promoting semen generation and preparation method thereof |
| CN1088809A (en) * | 1993-01-01 | 1994-07-06 | 广州市医药工业研究所 | The compound Chinese patent medicine of treatment male sterility |
| CN1092309A (en) * | 1993-03-16 | 1994-09-21 | 土荣华 | Heledan capsule and method for making thereof |
| CN1092308A (en) * | 1993-03-16 | 1994-09-21 | 土荣华 | Qiangjindan capsule and method for making thereof |
| CN1096679A (en) * | 1993-06-19 | 1994-12-28 | 张士舜 | A kind of sexual function accelerator for male |
| CN1107726A (en) * | 1994-12-12 | 1995-09-06 | 黄明和 | Efficient medicine for male sterility |
-
1995
- 1995-10-25 CN CN95113767.0A patent/CN1057452C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083710A (en) * | 1992-12-29 | 1994-03-16 | 南勋义 | Compound capsule for promoting semen generation and preparation method thereof |
| CN1088809A (en) * | 1993-01-01 | 1994-07-06 | 广州市医药工业研究所 | The compound Chinese patent medicine of treatment male sterility |
| CN1092309A (en) * | 1993-03-16 | 1994-09-21 | 土荣华 | Heledan capsule and method for making thereof |
| CN1092308A (en) * | 1993-03-16 | 1994-09-21 | 土荣华 | Qiangjindan capsule and method for making thereof |
| CN1096679A (en) * | 1993-06-19 | 1994-12-28 | 张士舜 | A kind of sexual function accelerator for male |
| CN1107726A (en) * | 1994-12-12 | 1995-09-06 | 黄明和 | Efficient medicine for male sterility |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1148961A (en) | 1997-05-07 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |