CN105727030A - 影像科主治鼻息肉的药物制剂及制备方法 - Google Patents
影像科主治鼻息肉的药物制剂及制备方法 Download PDFInfo
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- CN105727030A CN105727030A CN201610175259.9A CN201610175259A CN105727030A CN 105727030 A CN105727030 A CN 105727030A CN 201610175259 A CN201610175259 A CN 201610175259A CN 105727030 A CN105727030 A CN 105727030A
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Abstract
本发明公开了一种影像科主治鼻息肉的药物制剂,主要由下列原料药制备而成,均为质量份:柴胡1220,竹卷心610,天花粉814,通草513,知母48,枫香树根713,淡竹叶39,苎花48,苏头510,牛尾菜915,藁本49,野马蹄草710,桑叶36,牡荆子26。本发明选用中药植物材料制成,保证安全,疗效可靠,本组方根据中医药原则研制,具有解热凉血,消肿敛疮等功效,本发明见效快,疗效好,防复发,成本低,经济负担小。
Description
技术领域
本发明涉及中医中药领域,特别是涉及一种主治鼻息肉的药物制剂及制备方法。
背景技术
鼻息肉是鼻部常见疾病,是鼻腔内的赘生的良性组织,严重时可堵塞鼻腔。它是由于鼻粘膜长期炎性反应引起组织水肿的结果。鼻息肉多来源于中鼻道窦口、鼻道复合体和筛窦,高度水肿的鼻粘膜由中鼻道、窦口向鼻腔膨出下垂而形成息肉。发病年龄以中年人居多,男性略高于女性。鼻息肉的治疗主要为手术切除,但早期单发性鼻息肉症状较轻者,药物治疗有时可获得控制。鼻息肉双侧多发,单侧较少。常见的症状为持续性鼻塞随息肉体积长大而加重。鼻腔分泌物增多,时伴有喷嚏,分泌物可为浆液性、黏液性,如并发鼻窦感染,分泌物可为脓性。多有嗅觉障碍。鼻塞重者说话呈闭塞性鼻音,睡眠时打鼾。息肉蒂长者可感到鼻腔内有物随呼吸移动。后鼻孔息肉可致呼气时经鼻呼气困难,若息肉阻塞咽鼓管口,可引起耳鸣和听力减退。息肉阻塞鼻窦引流,可引起鼻窦炎,患者出现鼻背、额部及面颊部胀痛不适。
公布号CN105147898A(申请号201510432737.5)的中国专利文献公开了一种治疗鼻息肉的中药组合物,其组成原料的重量份为:白术3-4、雄黄2-4、藕节6-8、川芎4-5、升麻2-4、白芷7-9、苍耳子5-6、金银花13-18、余甘子1-2、红景天5-6、前胡2-4、虎杖7-8、炙甘草12-14、紫花地丁2-3、蜂窝房1-2、泽泻5-6、苦参3-4、青黛1-2、鹅不食草5-8、甜瓜茎4-6、铜锤草根2-4。公布号CN105168694A(申请号201510639439.3)的中国专利文献公开了一种治疗鼻息肉的中药组合物,由以下原料制成:香薷、胡荽、牛蒡子、蝉蜕、浮萍、天花粉、夏枯草、白鲜皮、芒硝、徐长卿、赤小豆、积雪草、野菊花、银耳、鹅不食草、远志、石菖蒲。公布号CN104815284A(申请号201510139268.8)的中国专利文献公开了一种治疗鼻息肉的中药组合物,其组成原料的重量份为:川芎4-6、薄荷10-12、桔梗8-10、黄芪5-7、金银花18-20、郁金4-6、三七2-4、茯苓1-3、柴胡8-10、苍耳子5-6、僵蚕2-4、鹅不食草6-8、雷公藤4-6、地骨皮2-4、白芷1-3、石菖蒲6-8、莪术3-5、西洋参2-4、五倍子5-6、葛根3-4、佩兰叶2-4、花拐藤根1-3和黄鳝藤2-4。
目前治疗鼻息肉的中药种类繁多,但疗效较好的却寥寥无几,手术治疗费用高,痛苦大,因此需要进一步改善治疗鼻息肉的配方,提高疗效,帮助患者解除痛苦。
发明内容
针对现有技术的不足,本发明的目的是提供一种制备简单、服用方便、便于携带、易久服的主治鼻息肉的药物制剂及制备方法。
本发明的技术方案是:
主治鼻息肉的药物制剂,主要由下列原料药制备而成,均为质量份:柴胡12-20,竹卷心6-10,天花粉8-14,通草5-13,知母4-8,枫香树根7-13,淡竹叶3-9,苎花4-8,苏头5-10,牛尾菜9-15,藁本4-9,野马蹄草7-10,桑叶3-6,牡荆子2-6。
优选的方案中,柴胡12-20,竹卷心6-10,天花粉8-14,通草5-13,知母4-8,枫香树根7-13,淡竹叶3-9,苎花4-8,苏头5-10,牛尾菜9-15,藁本4-9,野马蹄草7-10,桑叶3-6,牡荆子2-6。
更加优选的,柴胡16,竹卷心8,天花粉11,通草9,知母6,枫香树根10,淡竹叶6,苎花6,苏头7.5,牛尾菜12,藁本6.5,野马蹄草8.5,桑叶4.5,牡荆子4。
所述的主治鼻息肉的药物制剂的汤剂的制备方法,步骤如下:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的6倍,大火煮沸后加入步骤(1)和(2)所制原料药,再次煮沸后转小火煎15-20分钟(优选的,小火煎17分钟),过滤,收集滤液,滤渣加水再煮,加水量为总原料药质量的6倍,大火煮沸后加入淡竹叶、苎花和步骤(3)所制原料药,然后转小火煮,过滤,合并煎煮所得滤液,即得汤剂。
所述的主治鼻息肉的药物制剂汤剂的制备方法,步骤(4)然后转小火煮10-18分钟(优选的,小火煮12-16分钟;更加优选的,小火煮14分钟)。
所述的主治鼻息肉的药物制剂的片剂的制备方法,步骤如下:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的7倍,煎煮三次,每次大火煮沸后小火煎,过滤,收集滤液,合并煎煮所得滤液,浓缩成清膏,干燥,粉碎成药粉;
(5)将淡竹叶、苎花和步骤(1)(2)(3)所制原料药一起粉碎过120目筛,并与步骤(4)所制药粉混匀,将所制药粉制软材,制粒,整粒,压片,压制成圆形或其他形式的片状剂型。
所述的主治鼻息肉的药物制剂片剂的制备方法,步骤(4)每次大火煮沸后小火煎20-30分钟(优选的,小火煎23-27分钟;更加优选的,小火煎25分钟)。
所述的主治鼻息肉的药物制剂的散剂的制备方法,步骤如下:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的7倍,煎煮三次,每次大火煮沸后小火煎25分钟,过滤,收集滤液,合并煎煮所得滤液,浓缩成清膏,干燥,粉碎成药粉;
(5)将淡竹叶、苎花和步骤(1)(2)(3)所制原料药一起粉碎过筛,并与步骤(4)所制药粉混匀,即得散剂。
所述的主治鼻息肉的药物制剂散剂的制备方法,步骤(5)粉碎过120-240目筛(优选的,粉碎过140-200目筛;更加优选的,粉碎过180目筛)。
所述的主治鼻息肉的药物制剂的丸剂的制备方法,步骤如下:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的7倍,煎煮三次,每次大火煮沸后小火煎25分钟,过滤,收集滤液,合并煎煮所得滤液,浓缩成清膏,干燥,粉碎成药粉;
(5)将淡竹叶、苎花和步骤(1)(2)(3)所制原料药一起粉碎过80目筛,并与步骤(4)所制药粉混匀,加炼蜜和醋泛制成丸,干燥,即得丸剂。
所述的主治鼻息肉的药物制剂丸剂的制备方法,步骤(5)醋的量为药粉质量的0.8-1.0倍(优选的,醋的量为药粉质量的0.9倍)。
本发明提供的主治鼻息肉的药物制剂组方严谨,制备科学,所得产品服用方便。除此之外,本发明的优良效果还表现在:
1、本发明选用中药植物材料制成,保证安全,疗效可靠;
2、本组方根据中医药原则研制,具有解热凉血,消肿敛疮等功效;
3、本发明疗效显著,见效快,防复发,成本低,经济负担小。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不限于此。
实施例1主治鼻息肉的药物制剂,主要由下列原料药制备而成(每份10g):柴胡12份,竹卷心6份,天花粉8份,通草5份,知母4份,枫香树根7份,淡竹叶3份,苎花4份,苏头5份,牛尾菜9份,藁本4份,野马蹄草7份,桑叶3份,牡荆子2份。
上述主治鼻息肉的药物制剂汤剂的制备方法是:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的6倍,大火煮沸后加入步骤(1)和(2)所制原料药,再次煮沸后转小火煎17分钟,过滤,收集滤液,滤渣加水再煮,加水量为总原料药质量的6倍,大火煮沸后加入淡竹叶、苎花和步骤(3)所制原料药,然后转小火煮14分钟,过滤,合并煎煮所得滤液,即得汤剂。
实施例2主治鼻息肉的药物制剂,主要由下列原料药制备而成(每份10g):柴胡20份,竹卷心10份,天花粉14份,通草13份,知母8份,枫香树根13份,淡竹叶9份,苎花8份,苏头10份,牛尾菜15份,藁本9份,野马蹄草10份,桑叶6份,牡荆子6份。
主治鼻息肉的药物制剂片剂的制备方法是:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的7倍,煎煮三次,每次大火煮沸后小火煎25分钟,过滤,收集滤液,合并煎煮所得滤液,浓缩成清膏,干燥,粉碎成药粉;
(5)将淡竹叶、苎花和步骤(1)(2)(3)所制原料药一起粉碎过120目筛,并与步骤(4)所制药粉混匀,将所制药粉制软材,制粒,整粒,压片,压制成圆形或其他形式的片状剂型。
典型病例:xxx,女,46岁。主诉:患有慢性鼻窦炎6年,伴有鼻息肉,两年前曾感鼻咽干燥不适,头痛,嗅觉减退,伴有心烦,头闷,呼吸不畅,失眠等症状,医院检查,诊断为鼻息肉,住院行鼻息肉摘除术,后痊愈出院,近两个月,自感嗅觉再次减退,伴有呼吸不畅,脓涕不断,头晕,患者不想再手术,遂向中医求治。
后服用本实施例所得主治鼻息肉的药物制剂片剂,每天2次,每次2-3片,温开水送服,7天一个疗程。服用1个疗程后,头晕减轻,服用2个疗程后,脓涕明显减少,呼吸较之前顺畅,服用4个疗程后,不适症状基本消除,坚持服用6个疗程后,鼻腔表面光滑,嗅觉恢复正常,无不适症状,随访一年,无复发。
实施例3主治鼻息肉的药物制剂,主要由下列原料药制备而成(每份10g):柴胡12份,竹卷心6份,天花粉8份,通草5份,知母4份,枫香树根7份,淡竹叶3份,苎花4份,苏头5份,牛尾菜9份,藁本4份,野马蹄草7份,桑叶3份,牡荆子2份。
主治鼻息肉的药物制剂散剂的制备方法是:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的7倍,煎煮三次,每次大火煮沸后小火煎25分钟,过滤,收集滤液,合并煎煮所得滤液,浓缩成清膏,干燥,粉碎成药粉;
(5)将淡竹叶、苎花和步骤(1)(2)(3)所制原料药一起粉碎过180目筛,并与步骤(4)所制药粉混匀,即得散剂。
典型病例:xxx,男,62岁。主诉:两年前诊断出患有鼻息肉,经常鼻塞,鼻腔干燥,近半个月不适症状加重,鼻塞无流涕,鼻干口干,夜间睡眠不宁,常被闷醒,医院检查,建议行摘除术,患者惧怕手术,遂转至中医院治疗。
服用本实施例所得主治鼻息肉的药物制剂散剂,采用每天2次,每次4-6g,用温开水冲服,7天一个疗程。服用1个疗程后,鼻塞明显减轻,鼻干口干改善,服用3个疗程后,患者不适症状基本消除,服用5个疗程后,患者呼吸顺畅,睡眠安稳,痊愈,一年内随访无不适症状。
实施例4主治鼻息肉的药物制剂,主要由下列原料药制备而成(每份10g):柴胡20份,竹卷心10份,天花粉14份,通草13份,知母8份,枫香树根13份,淡竹叶9份,苎花8份,苏头10份,牛尾菜15份,藁本9份,野马蹄草10份,桑叶6份,牡荆子6份。
主治鼻息肉的药物制剂丸剂的制备方法是:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的7倍,煎煮三次,每次大火煮沸后小火煎25分钟,过滤,收集滤液,合并煎煮所得滤液,浓缩成清膏,干燥,粉碎成药粉;
(5)将淡竹叶、苎花和步骤(1)(2)(3)所制原料药一起粉碎过80目筛,并与步骤(4)所制药粉混匀,加炼蜜和醋泛制成丸(醋的量为药粉质量的0.9倍),干燥,即得丸剂。
典型病例:xxx,男,36岁。主诉:一个月前不慎感冒,出现咳嗽、鼻塞等症状,服药一周后其他症状均消失,但仍感鼻塞,嗅觉下降,后服用鼻炎用药,症状稍有好转,但效果不佳,医院检查,诊断为鼻息肉,后服用多种西药仍未见好转,医生建议手术治疗,患者拒绝。
经人介绍服用本实施例所得主治鼻息肉的药物制剂丸剂,采用每天2次,每次4粒,用温开水送服,7天一个疗程。服用1个疗程后,鼻塞减轻,服用2个疗程后,呼吸通畅,服用4个疗程后,无不适症状,复查,双侧鼻息肉消失,嗅觉功能恢复,一年内随访无反复。
实施例5主治鼻息肉的药物制剂,主要由下列原料药制备而成(每份10g):柴胡16份,竹卷心8份,天花粉11份,通草9份,知母6份,枫香树根10份,淡竹叶6份,苎花6份,苏头7.5份,牛尾菜12份,藁本6.5份,野马蹄草8.5份,桑叶4.5份,牡荆子4份。
主治鼻息肉的药物制剂汤剂的制备方法是:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的6倍,大火煮沸后加入步骤(1)和(2)所制原料药,再次煮沸后转小火煎17分钟,过滤,收集滤液,滤渣加水再煮,加水量为总原料药质量的6倍,大火煮沸后加入淡竹叶、苎花和步骤(3)所制原料药,然后转小火煮14分钟,过滤,合并煎煮所得滤液,即得汤剂。
本发明所用主要中药原料的药理如下:
柴胡:基原:为伞形科植物柴胡或狭叶柴胡的干燥根。性味:苦,微寒。归经:归肝、胆经。功能主治:和解表里,疏肝,升阳。用于感冒发热,寒热往来,胸胁胀痛,月经不调,子官脱垂,脱肛。
竹卷心:基原:为禾本科植物淡竹的卷而未放的幼叶。性味:苦,寒,淡,甘。归经:心,肝经。功能主治:清心除烦,利尿,解毒。主热病烦渴,小便短赤,烧烫伤。
天花粉:基原:为葫芦科植物栝楼或双边栝楼的干燥根。性味:甘、微苦,微寒。归经:归肺、胃经。功能主治:清热生津,消肿排脓。用于热病烦渴,肺热燥咳,内热消渴,疮疡肿毒。
通草:基原:为五加科植物通脱木的干燥茎髓。性味:甘、淡,微寒。归经:归肺、胃经。功能主治:清热利尿,通气下乳。用于湿温尿赤,淋病涩痛,水肿尿少,乳汁不下。
知母:基原:为百合科植物知母的干燥根茎。性味:苦、甘,寒。归经:归肺、胃、肾经。功能主治:清热泻火,生津润燥。用于外感热病,高热烦渴,肺热燥咳,骨蒸潮热,内热消渴,肠燥便秘。
枫香树根:基原:为金缕梅科植物枫香的树根。性味:辛,苦,平。归经:脾,肾,肝经。功能主治:解毒消肿,祛风止痛。主痈疽疔疮,风湿痹痛,牙痛,湿热泄泻,痢疾,小儿消化不良
淡竹叶:基原:为禾本科植物淡竹叶的干燥茎叶。性味:甘、淡,寒。归经:归心、胃、小肠经。功能主治:清热除烦,利尿。用于热病烦渴,小便赤涩淋痛,口舌生疮。
苎花:基原:为荨麻科植物苎麻的花。性味:甘,性寒。功能主治:清心除烦,凉血透疹。主心烦失眠,口舌生疮,麻疹透发不畅,风疹瘙痒。
苏头:基原:为唇形科植物皱紫苏、尖紫苏或白苏的根及近根的老茎。性味:味辛,性温。归经:归肺,脾经。功能主治:疏风散寒,降气祛痰,和中安胎。主头晕,身痛,鼻塞流涕,咳逆上气,胸隔饮,胸闷肋痛,腹痛泄泻,妊娠呕吐,胎动不安。
牛尾菜:基原:为百合科植物牛尾菜的根及根茎。性味:甘、苦,平。功能主治:祛风活络,祛痰止咳。用于风湿性关节炎,筋骨疼痛,跌打损伤,腰肌劳损,支气管炎,肺结核咳嗽咯血。
藁本:基原:为伞形科植物藁本或辽藁本、火藁本的根茎及根。性味:辛,温。归经:归膀胱经。功能主治:祛风,散寒,除湿,止痛。用于风寒感冒,巅顶疼痛,风湿肢节痹痛。
野马蹄草:基原:为莎草科植物萤蔺的全草。性味:甘、淡,凉。功能主治:清热解毒,凉血利水。主治肺痨咳血,风火牙痛,目赤肿痛,尿路感染。
桑叶:基原:为桑科植物桑的干燥叶。性味:甘、苦,寒。归经:归肺、肝经。功能主治:疏散风热,清肺润燥,清肝明目。用于风热感冒,肺热燥咳,头晕头痛,目赤昏花。
牡荆子:基原:为马鞭草科植物牡荆的果实。性味:味苦,辛,性温。归经:归肺,大肠经。功能主治:化湿祛痰,止咳平喘,理气止痛。主咳嗽气喘,胃痛,泄泻,痢疾,疝气痛,脚气肿胀,白带,白浊。
试验例1本发明所得主治鼻息肉的药物制剂(实施例5)的临床应用:
2013年1月-2015年2月,在5所医院耳鼻喉科门诊筛选320例鼻息肉患者,其中女性134例,男性186例,年龄18-65岁,平均年龄(43.3±8.4)岁,病程1-14年,平均病程(5.2±1.2)年。所有患者均经鼻窦CT扫描,鼻内窥镜检查确诊。临床表现为不同程度的反复鼻塞、流鼻涕/脓涕、嗅觉减退和头痛等症状。
将患者随机分为两组,实验组200例和对照组120例,两组在性别、年龄、病程、病情等方面无显著差异(P>0.05),具有可比性。实验组服用本发明所得产品,每天服用两次(温热),每次250m1-300m1(视具体情况有所调整),7天一个疗程,对照组服用其它药品(开瑞坦和普米克等常规药品)。治疗期间对两组患者进行连续观察,记录症状及变化。
疗效情况判定标准:治愈:临床症状消失,内窥镜显示窦口开放良好,窦腔黏膜完全上皮化,无分泌物;有效:临床症状明显改善,内窥镜显示窦腔黏膜未上皮化,有少量脓性分泌物;无效:服用前后,不适症状无改善,窦口堵塞,有脓性分泌物。
服用4个疗程后,实验组患者,治愈121例(60.5%),有效72例(36.0%),实验组总有效率96.5%。对照组中,治愈55例(45.8%),有效45例(37.5%),对照组总有效率为83.3%,治疗半年后,实验组有10例(5.2%)患者复发,对照组有22例(18.3%)患者复发,两组相比,实验组的复发率低于对照组,两组存在显著性差异(P<0.05)。
本发明选择柴胡可和解表里,竹卷心、淡竹叶和苎花可清心除烦,天花粉可消肿排脓,通草可清热利尿,知母可清热泻火,枫香树根可解毒消肿,苏头可疏风散寒,牛尾菜可祛风活络,藁本可散寒除湿,野马蹄草可凉血利水,桑叶可疏散风热,牡荆子可化湿祛痰,多种中药材料联用,可奏解热凉血,消肿敛疮等功效。
应当指出的是,具体实施方式只是本发明比较有代表性的例子,显然本发明的技术方案不限于上述实施例,还可以有很多变形。本领域的普通技术人员,以本发明所明确公开的或根据文件的书面描述毫无异议的得到的,均应认为是本专利所要保护的范围。
Claims (10)
1.主治鼻息肉的药物制剂,其特征在于,主要由下列原料药制备而成,均为质量份:柴胡12-20,竹卷心6-10,天花粉8-14,通草5-13,知母4-8,枫香树根7-13,淡竹叶3-9,苎花4-8,苏头5-10,牛尾菜9-15,藁本4-9,野马蹄草7-10,桑叶3-6,牡荆子2-6。
2.如权利要求1所述的主治鼻息肉的药物制剂,其特征在于,柴胡12-20,竹卷心6-10,天花粉8-14,通草5-13,知母4-8,枫香树根7-13,淡竹叶3-9,苎花4-8,苏头5-10,牛尾菜9-15,藁本4-9,野马蹄草7-10,桑叶3-6,牡荆子2-6(优选的,柴胡16,竹卷心8,天花粉11,通草9,知母6,枫香树根10,淡竹叶6,苎花6,苏头7.5,牛尾菜12,藁本6.5,野马蹄草8.5,桑叶4.5,牡荆子4)。
3.如权利要求1-2任一所述的主治鼻息肉的药物制剂的汤剂的制备方法,其特征在于,步骤如下:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的6倍,大火煮沸后加入步骤(1)和(2)所制原料药,再次煮沸后转小火煎15-20分钟(优选的,小火煎17分钟),过滤,收集滤液,滤渣加水再煮,加水量为总原料药质量的6倍,大火煮沸后加入淡竹叶、苎花和步骤(3)所制原料药,然后转小火煮,过滤,合并煎煮所得滤液,即得汤剂。
4.如权利要求3所述的主治鼻息肉的药物制剂汤剂的制备方法,其特征在于,步骤(4)然后转小火煮10-18分钟(优选的,小火煮12-16分钟;更加优选的,小火煮14分钟)。
5.如权利要求1-2任一所述的主治鼻息肉的药物制剂的片剂的制备方法,其特征在于,步骤如下:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的7倍,煎煮三次,每次大火煮沸后小火煎,过滤,收集滤液,合并煎煮所得滤液,浓缩成清膏,干燥,粉碎成药粉;
(5)将淡竹叶、苎花和步骤(1)(2)(3)所制原料药一起粉碎过120目筛,并与步骤(4)所制药粉混匀,将所制药粉制软材,制粒,整粒,压片,压制成圆形或其他形式的片状剂型。
6.如权利要求5所述的主治鼻息肉的药物制剂片剂的制备方法,其特征在于,步骤(4)每次大火煮沸后小火煎20-30分钟(优选的,小火煎23-27分钟;更加优选的,小火煎25分钟)。
7.如权利要求1-2任一所述的主治鼻息肉的药物制剂的散剂的制备方法,其特征在于,步骤如下:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的7倍,煎煮三次,每次大火煮沸后小火煎25分钟,过滤,收集滤液,合并煎煮所得滤液,浓缩成清膏,干燥,粉碎成药粉;
(5)将淡竹叶、苎花和步骤(1)(2)(3)所制原料药一起粉碎过筛,并与步骤(4)所制药粉混匀,即得散剂。
8.如权利要求7所述的主治鼻息肉的药物制剂散剂的制备方法,其特征在于,步骤(5)粉碎过120-240目筛(优选的,粉碎过140-200目筛;更加优选的,粉碎过180目筛)。
9.如权利要求1-2任一所述的主治鼻息肉的药物制剂的丸剂的制备方法,其特征在于,步骤如下:
(1)取通草置于蒸锅内,隔水蒸10分钟取出,切片后加黑豆汁拌匀,置于炒锅内,文火加热至原料药表面微黄时,取出;
(2)将枫香树根、苏头和藁本加米泔水煮,煮20分钟后,取出,用和好的面包裹,放入热沙中煨至面黄黑取出,除去表面的面块,晾凉;
(3)取竹卷心和桑叶加醋和盐拌匀,静置15分钟,取出,置于炒锅内,炒至表面干燥,取出,晾凉;
(4)将柴胡、天花粉、知母、牛尾菜、野马蹄草和牡荆子加水煎煮,加水量为所煮原料药质量的7倍,煎煮三次,每次大火煮沸后小火煎25分钟,过滤,收集滤液,合并煎煮所得滤液,浓缩成清膏,干燥,粉碎成药粉;
(5)将淡竹叶、苎花和步骤(1)(2)(3)所制原料药一起粉碎过80目筛,并与步骤(4)所制药粉混匀,加炼蜜和醋泛制成丸,干燥,即得丸剂。
10.如权利要求9所述的主治鼻息肉的药物制剂丸剂的制备方法,其特征在于,步骤(5)醋的量为药粉质量的0.8-1.0倍(优选的,醋的量为药粉质量的0.9倍)。
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CN104546969A (zh) * | 2013-10-26 | 2015-04-29 | 张福增 | 治疗鼻息肉的药物配方及用法 |
CN105168694A (zh) * | 2015-09-30 | 2015-12-23 | 吴淑芬 | 一种治疗鼻息肉的中药组合物 |
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CN104546969A (zh) * | 2013-10-26 | 2015-04-29 | 张福增 | 治疗鼻息肉的药物配方及用法 |
CN105168694A (zh) * | 2015-09-30 | 2015-12-23 | 吴淑芬 | 一种治疗鼻息肉的中药组合物 |
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