CN105726970A - Medicine composition for treating early threatened abortion caused by deficiency of kidney yang - Google Patents
Medicine composition for treating early threatened abortion caused by deficiency of kidney yang Download PDFInfo
- Publication number
- CN105726970A CN105726970A CN201610183867.4A CN201610183867A CN105726970A CN 105726970 A CN105726970 A CN 105726970A CN 201610183867 A CN201610183867 A CN 201610183867A CN 105726970 A CN105726970 A CN 105726970A
- Authority
- CN
- China
- Prior art keywords
- parts
- kidney yang
- threatened abortion
- treatment
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000003734 kidney Anatomy 0.000 title claims abstract description 59
- 239000003814 drug Substances 0.000 title claims abstract description 56
- 206010000242 Abortion threatened Diseases 0.000 title claims abstract description 41
- 208000005985 Threatened Abortion Diseases 0.000 title claims abstract description 41
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 229940079593 drug Drugs 0.000 title abstract description 19
- 230000007812 deficiency Effects 0.000 title abstract description 11
- 238000011282 treatment Methods 0.000 claims abstract description 64
- 238000002360 preparation method Methods 0.000 claims abstract description 23
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 208000011580 syndromic disease Diseases 0.000 claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims description 27
- 241001506333 Polyalthia Species 0.000 claims description 26
- 208000031975 Yang Deficiency Diseases 0.000 claims description 23
- 210000000582 semen Anatomy 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 239000002775 capsule Substances 0.000 claims description 20
- 238000002481 ethanol extraction Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 239000002552 dosage form Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 239000003826 tablet Substances 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 6
- 235000019640 taste Nutrition 0.000 claims description 6
- 239000000470 constituent Substances 0.000 claims description 5
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 5
- 239000013049 sediment Substances 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- -1 sublimed preparation Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 20
- 210000004369 blood Anatomy 0.000 abstract description 15
- 239000008280 blood Substances 0.000 abstract description 15
- 210000004185 liver Anatomy 0.000 abstract description 14
- 210000000952 spleen Anatomy 0.000 abstract description 12
- 230000008901 benefit Effects 0.000 abstract description 7
- 235000019606 astringent taste Nutrition 0.000 abstract description 4
- 230000001502 supplementing effect Effects 0.000 abstract description 4
- 238000002560 therapeutic procedure Methods 0.000 abstract description 4
- 238000010792 warming Methods 0.000 abstract description 4
- 206010000210 abortion Diseases 0.000 abstract description 3
- 231100000176 abortion Toxicity 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 2
- 241000110637 Cuscuta chinensis Species 0.000 abstract 1
- 241000608174 Gymnadenia Species 0.000 abstract 1
- 241000157491 Morinda Species 0.000 abstract 1
- 241000756042 Polygonatum Species 0.000 abstract 1
- 235000008737 Polygonatum biflorum Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 241000316342 Taxillus Species 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000017524 noni Nutrition 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 20
- 235000009508 confectionery Nutrition 0.000 description 12
- 208000002193 Pain Diseases 0.000 description 11
- 238000003745 diagnosis Methods 0.000 description 11
- 230000035935 pregnancy Effects 0.000 description 11
- 208000032843 Hemorrhage Diseases 0.000 description 10
- 210000004291 uterus Anatomy 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 8
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 235000019634 flavors Nutrition 0.000 description 8
- 210000001015 abdomen Anatomy 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 208000037920 primary disease Diseases 0.000 description 7
- 206010000087 Abdominal pain upper Diseases 0.000 description 6
- 230000001605 fetal effect Effects 0.000 description 6
- 238000011835 investigation Methods 0.000 description 6
- 230000033001 locomotion Effects 0.000 description 6
- 230000027939 micturition Effects 0.000 description 6
- 238000002604 ultrasonography Methods 0.000 description 6
- 210000000988 bone and bone Anatomy 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 210000003127 knee Anatomy 0.000 description 5
- 210000003205 muscle Anatomy 0.000 description 5
- 230000003014 reinforcing effect Effects 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 210000001215 vagina Anatomy 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000008175 fetal development Effects 0.000 description 4
- 210000003754 fetus Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000186 progesterone Substances 0.000 description 4
- 229960003387 progesterone Drugs 0.000 description 4
- 238000005728 strengthening Methods 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 208000009205 Tinnitus Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 238000003748 differential diagnosis Methods 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 230000002124 endocrine Effects 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 201000001881 impotence Diseases 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 210000001161 mammalian embryo Anatomy 0.000 description 3
- 206010029446 nocturia Diseases 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 231100000886 tinnitus Toxicity 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- SJSOFNCYXJUNBT-UHFFFAOYSA-N 3,4,5-trimethoxybenzoic acid Chemical compound COC1=CC(C(O)=O)=CC(OC)=C1OC SJSOFNCYXJUNBT-UHFFFAOYSA-N 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 2
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000008967 Enuresis Diseases 0.000 description 2
- 206010051459 Imminent abortion Diseases 0.000 description 2
- 206010028813 Nausea Diseases 0.000 description 2
- 206010059013 Nocturnal emission Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 208000032023 Signs and Symptoms Diseases 0.000 description 2
- 208000035010 Term birth Diseases 0.000 description 2
- 206010046788 Uterine haemorrhage Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 229940015047 chorionic gonadotropin Drugs 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000008093 supporting effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000009530 yishen Substances 0.000 description 2
- XFOOPZIJVVDYHI-BQBZGAKWSA-N (2s)-2-amino-6-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-6-oxohexanoic acid Chemical compound OC(=O)[C@@H](N)CCCC(=O)N[C@@H](CS)C(=O)NCC(O)=O XFOOPZIJVVDYHI-BQBZGAKWSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 208000001362 Fetal Growth Retardation Diseases 0.000 description 1
- 206010070531 Foetal growth restriction Diseases 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 206010048461 Genital infection Diseases 0.000 description 1
- 208000008899 Habitual abortion Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 208000009233 Morning Sickness Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 241000590428 Panacea Species 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 206010043949 Tongue discolouration Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 208000034850 Vomiting in pregnancy Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 235000004251 balanced diet Nutrition 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 231100000481 chemical toxicant Toxicity 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000010482 emotional regulation Effects 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 208000030941 fetal growth restriction Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 229940088592 immunologic factor Drugs 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 231100000545 luteal phase defect Toxicity 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000036473 myasthenia Effects 0.000 description 1
- 229960000715 nimodipine Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 208000012113 pregnancy disease Diseases 0.000 description 1
- 238000009597 pregnancy test Methods 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of traditional Chinese medicines and relates to a medicine composition for treating early threatened abortion caused by deficiency of kidney yang and a preparation method thereof. The medicine composition is elaborately prepared by using Chinese dodder seed, prepared rhizome of adhesive rehmannia, morinda root, root of woods greenstar, Chinese taxillus twig, Chinese magnoliavine fruit, rhizome of conic gymnadenia and fragrant solomonseal rhizome as medicinal raw materials. The medicine composition has the advantages that the medicines are combined, interact, are indispensable and have the functions of warming and invigorating kidney yang, tonifying the spleen and nourishing the liver, supplementing qi and nourishing blood and preventing abortion by astringency; and the medicine composition can achieve the effects of tonifying kidney yang, tonifying the spleen and regulating the liver when being used for treating patients suffering early threatened abortion caused by deficiency of kidney yang, has obviously better treatment effects than western medicine therapy, shows enormous advantages of traditional Chinese medicines in early threatened abortion and is worthy of being further studied and applied.
Description
Technical field
The invention belongs to tcm field, relate to pharmaceutical composition of a kind of kidney yang deficiency syndrome early stage threatened abortion and preparation method thereof.
Background technology
Early stage threatened abortion is the commonly encountered diseases of department of obstetrics and gynecology, account for the 15% of gestation, refer to that gestation occurred before 12 weeks hemorrhage on a small quantity with vagina, companion's lower abdomen pendant pain or soreness of waist pain etc. are the disease of main clinical manifestation, early stage threatened abortion wishes to continue to gestation through having a rest and still having after treatment, if but do not give attention, then it would be likely to develop into inevitable abortion.In recent years, the sickness rate of threatened abortion raises year by year, and primary disease has the tendency repeatedly occurred, not only cause the injury of patient's body and mind, have an effect on family, social stablizing, therefore how effectively to prevent and treat early stage threatened abortion, and be effectively extended to clinic, apply to patient easily, be always up the direction that medical circle is made great efforts.
Generally believe clinically and cause a lot of because have of threatened abortion; such as operating pressure is excessive, emotion excessively anxiety and anxiety, and living environment is polluted, and sucks or contact too much toxic chemical substance; anemia of pregnant woman occurs that microorganism is infected, and the reason such as exception or endocrine regulation occurs in immunologic function.Western medical treatment early stage threatened abortion approach is single, and routine gives supplementary progesterone, vitamin E, chorionic-gonadotropin hormone (HCG), and it is only effective to luteal phase defect person to supplement progesterone, and person caused by immune factor adopts active immunization to treat.
Primary disease is early on the books in motherland's medical science.Threatened abortion belongs to the category of motherland's medical science " vaginal bleeding during pregnancy ", " frequent fetal movement ".For a long time in the understanding to primary disease, motherland's medical science have accumulated the experience of many preciousnesses.Zhang Zhongjing it " Medical Treasures of the Golden Chamber married woman's gestation abnormal pulse is demonstrate,proved and controlled " in Han dynasty proposes to dissipate antiabortive fetus nourishing with Chinese angelica powder and the Rhizoma Atractylodis Macrocephalae, controls the record of abdominal pain during pregnancy in addition with Ass-hide Glue and Argyi Leaf Decoction, opens the beginning that the in love product of flesh and blood are antiabortive, is the source of antiabortive principle-method-recipe-medicines later age.Song dynasty " female section hundred is asked " proposes Cortex Eucommiae ball and treats the hardship of frequent fetal movement.Yuan Dynasty's ZHU Dan-xi proposes saying of " Radix Scutellariae, the Rhizoma Atractylodis Macrocephalae being antiabortive panacea ", affects later age so far.Ming Dynasty's Zhang Jingyue " Jing Yue's complete work married woman rule " emphasizes that determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is antiabortive, and first propose dynamically to observe the weight change of the big symptom (stomachache, hematochezia, the soreness of waist, tenesmus) of frequent fetal movement four, whether prediction embryo survival, to determine antiabortive or lower tire, perfect pregnancy disease " cure the disease and develop simultaneously with antiabortive " and the big rule for the treatment of of " lower tire " two, propose the prevention thought of " its damage of pre-training " simultaneously, instruct clinic so far.Qing Dynasty's "Fu Qingzhu works on obstetric" extensively discusses antiabortive seven methods, and Wang Qingren proposes the antiabortive method of blood stasis dispelling in " correction of the errors of medical works SHAOFU ZHUYN DECOCTION ".Lid nausea is uneasy, must to some extent because of, or empty or real or cold or heat, can be all the disease of nausea.Go to its institute sick, be antiabortive method." later age under the guide of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, in conjunction with the continuous summing up experience of clinical practice, gradually formed the multiple method of multiple treatment primary disease.Chinese medicine primary disease determined curative effect, non-evident effect, easily accept for patient and his family.
Summary of the invention
"Fu Qingzhu works on obstetric" says " one-tenth of husband's tire becomes the essence of kidney ".Kidney yin, kidney yang combined effect under, just make uterus have consolidating semen to become pregnant, educate viviparous long physiological function.Kidney storing essence, essence is the material base of fetus nourishing；Kidney essense is abundant, and born of the same parents must nourish, and needs fetus nourishing unit to give a birth to phase maturation；And kidney the yang aspect of yang, then uterus being played warm biochemical action, born of the same parents get Qi Wen only just can be made under the evaporation of kidney yang not tremble with fear, menses are smooth and not stagnant, and it is warm and can grow up that tire obtains it；Suffer from a deficiency of the kidney the then debility of CHONG and REN meridians, frequent fetal movement, send out as primary disease.
Inventor is on the basis of recipe handed down from ancestors, in conjunction with body constitution and the modern medical theory of modern, dialectical combines with differential diagnosis of diseases, it is provided that the pharmaceutical composition of the treatment kidney yang deficiency syndrome early stage threatened abortion that a kind of curative effect is determined, side effect is little.
The technical solution used in the present invention is as follows:
A kind of pharmaceutical composition treating kidney yang deficiency syndrome early stage threatened abortion, it is characterised in that be that medicinal raw material is made by Semen Cuscutae, Radix Rehmanniae Preparata, Radix Morindae Officinalis, Polyalthia nemoralis A. D C., Herba Taxilli, Fructus Schisandrae Chinensis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati.
Indivedual medicinal raw materials in the present invention have the kidney invigorating, antiabortive, spleen invigorating, effect of nourishing blood, but all not there is good curative effect, the artificial synergism increasing effective active composition of invention, by lot of experiments research persistent exploration, is finally obtained following technical scheme:
A kind of pharmaceutical composition treating kidney yang deficiency syndrome early stage threatened abortion, it is characterised in that be made up of the medicinal raw material of following weight: Semen Cuscutae 13-18 part, Radix Rehmanniae Preparata 8-13 part, Radix Morindae Officinalis 7-12 part, Polyalthia nemoralis A. D C. 10-15 part, Herba Taxilli 5-8 part, Fructus Schisandrae Chinensis 2.5-4.5 part, Rhizoma Gymnadeniae 20-25 part, Rhizoma Polygonati Odorati 7-12 part.
Further, a kind of pharmaceutical composition treating kidney yang deficiency syndrome early stage threatened abortion, it is characterised in that be made up of the medicinal raw material of following weight: Semen Cuscutae 15 parts, Radix Rehmanniae Preparata 10 parts, Radix Morindae Officinalis 10 parts, Polyalthia nemoralis A. D C. 15 parts, Herba Taxilli 7 parts, Fructus Schisandrae Chinensis 4 parts, Rhizoma Gymnadeniae 25 parts, Rhizoma Polygonati Odorati 10 parts.
Fang Zhong: the sweet temperature of Semen Cuscutae, tonifying kidney and nourishing liver, warming the spleen helps stomach, and nourishing YIN is YANG invigorating again, and astringency inducing punching is appointed, for monarch drug.Radix Morindae Officinalis Xin Ganwen, reinforcing the kidney and supporting YANG is held concurrently and is dissipated evil and expelling wind and removing dampness, bone and muscle strengthening, the sweet temperature of Radix Rehmanniae Preparata, nourishing YIN and supplementing blood, and benefit essence fills out marrow, two medicine 5 kidney-replenishing blood-nourishings, negative and positive alternate, helps kidney qi to grow, Yuanyang benefit Sheng, for ministerial drug.Polyalthia nemoralis A. D C. is sweet flat, invigorating spleen and reinforcing stomach, tonifying the kidney to consolidate the essence；Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, the meridian dredging, replenishing QI and blood, antiabortive；Rhizoma Gymnadeniae is sweet flat, and Yishen Jianpi is regulated the flow of vital energy and blood, hemostasis and pain-relieving, calms the nerves relieving convulsion；Trimethyl gallic acid is held back and is promoted the production of body fluid, protect reinforcing premodial qi, above enter lung, under enter kidney, entering lung has the benefit of Jiyuan of promoting the production of body fluid, enter kidney have controlling nocturnal emission with astringent drugs support marrow merit；Sweet cold the alcohol of Rhizoma Polygonati Odorati is good, and abnormal smells from the patient eases up, therefore can grow tonifying YIN essence, increases yang-energy, with and poor, five medicines are adjuvant drug.All medicine 5 use, interacts, indispensable, has warming and recuperating the kidney-YANG, spleen invigorating nourishing the liver, benefiting QI and nourishing blood, effect that astringency inducing is antiabortive.
The medicinal part that medicinal raw material of the present invention is all recorded in the ancient books and records such as " Chinese Pharmacopoeia ", " China's book on Chinese herbal medicine " is for standard, and pharmacological activity present Research is as described below.
Semen Cuscutae: [nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down；Externally treating leucoderma.
Radix Rehmanniae Preparata: [nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, benefit essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizziness, tinnitus, early whitening of beard and hair.[usage and dosage] 9～15g.
Radix Morindae Officinalis: [nature and flavor] Xin Gan；Temperature.[return through] liver；Kidney channel.[function cures mainly] reinforcing the kidney and supporting YANG；Bone and muscle strengthening；Expelling wind and removing dampness.Main impotence due to deficiency of the kidney；Seminal emission premature ejaculation；Few abdomen cold type of pain；Incontinence of urine；Cold womb is infertile；Anemofrigid-damp arthralgia；Soreness of the waist and knees；Rheumatism limb gas.
Polyalthia nemoralis A. D C.: [nature and flavor] are sweet is flat.[function cures mainly] invigorating spleen and reinforcing stomach, tonifying the kidney to consolidate the essence.Controlling chronic gastritis, taste lose, inappetence, myasthenia of limbs, seminal emission.
Herba Taxilli: [nature and flavor] bitter, sweet, flat.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement；Hypertension.
Fructus Schisandrae Chinensis: [nature and flavor] are sour, sweet, temperature.[return through] returns lung, the heart, kidney channel.[function cures mainly] restrains astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.[usage and dosage] 1.5～6g.
Rhizoma Gymnadeniae: [nature and flavor] are sweet；Flat.[return through] lung；Spleen；Stomach warp.[function cures mainly] relieving cough and asthma；Yishen Jianpi；Regulate the flow of vital energy and blood；Pain relieving.Main cough and asthma due to lung deficiency；Asthenia is become thin；Neurasthenia；Suffer from a deficiency of the kidney lassitude loin and legs；Sexual impotence；Spermatorrhea；Frequent micturition；Chronic hepatitis；Chronic diarrhea；Lose blood；Leukorrhagia；Breast is few；Traumatic injury.
Rhizoma Polygonati Odorati: [nature and flavor] are sweet, are slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Hindering for lung stomach-Yin, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.
A kind of method that present invention also offers pharmaceutical composition preparing treatment kidney yang deficiency syndrome early stage threatened abortion.
The method of a kind of pharmaceutical composition preparing treatment kidney yang deficiency syndrome early stage threatened abortion provided by the invention, mainly comprises the steps that
(1) take Radix Morindae Officinalis, Polyalthia nemoralis A. D C. add medical material amount 5-8 times 50% ethanol water, extract secondary, each 1.5 hours, filtered while hot, be concentrated into and obtain ethanol extraction concentrated solution without alcohol taste；
(2) take Semen Cuscutae, Radix Rehmanniae Preparata, Herba Taxilli, Fructus Schisandrae Chinensis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati together with filtering residue after Radix Morindae Officinalis, Polyalthia nemoralis A. D C. ethanol extraction, add 5-8 times of water soaking 3-4 hour, decoct extraction twice, each 1.0-2.0 hour；Filtered while hot, it is concentrated into relative density 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content be 30% (volume ratio), after standing 24 hours, discard lower sediment thing, obtain supernatant, be concentrated into relative density 1.05-1.10 (60 DEG C record) and mix with above-mentioned ethanol extraction concentrated solution afterwards, under inlet temperature 140～150 DEG C, 75～80 DEG C of conditions of leaving air temp, carry out spray drying obtain active constituents of medicine；This composition individually or mixes with pharmaceutically acceptable carrier, makes according to galenic pharmacy routine techniques.
In order to express the pharmaceutical composition of the present invention better, the pharmaceutical composition of the present invention can be prepared as dosage form conventional clinically.Being preferably, pharmaceutical composition described above prepares into oral formulations, i.e. powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, tablet, capsule etc..It is highly preferred that pharmaceutical composition of the present invention conventionally preparation technology prepares into granule, tablet or capsule；Most preferably, pharmaceutical composition described above prepares into capsule.
The present invention is also claimed aforementioned pharmaceutical compositions purposes in preparation treatment kidney yang deficiency syndrome early stage threatened abortion medicine.Pharmaceutical composition of the present invention is when treatment early stage threatened abortion, particularly during kidney yang deficiency syndrome early stage threatened abortion, it is shown that activity significantly.Clinical observation experiment embodiment 9 of the present invention shows, compare with western medicine group: in clinical total effects: treatment group and matched group total effective rate respectively 92.5% and 72.5%, two groups of total effective rate comparing differences statistically significant (P < 0.05), the curative effect for the treatment of group is substantially better than matched group；In TCM symptom score compares: after the treatment for the treatment of group, TCM symptom score is all substantially more less than before treatment, with comparing difference statistically significant (P < 0.01) before treatment, matched group compares with before treatment, difference statistically significant (P < 0.05)；Comparing between two groups after treatment, treatment group is better than matched group in improving tcm symptom, and the minimizing for the treatment of group symptom integral becomes apparent from, difference statistically significant (P < 0.01).
The present invention relatively and prior art, has following clear superiority:
Chinese medicine preparation prescription of the present invention mainly develops according to the pathogenic characteristic of kidney yang deficiency syndrome early stage threatened abortion, and full side closes 5 warming and recuperating the kidney-YANG, spleen invigorating nourishing the liver, benefiting QI and nourishing blood, effect that astringency inducing is antiabortive.
The component of the present composition all adopts natural raw material of Chinese medicine, and preparation is easy, medicine source is wide, cost is low for it.It follows the prescriptions principle of the traditional Chinese medical science, reliable effect, mild in medicine property and, toxic and side effects does not occur.
Chinese medicine preparation of the present invention adopts advanced extraction equipment and technique, abundant effective component extracting, can be made into Chinese medicine preparation that is convenient oral or that carry, such as tablet, capsule or granule.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example.Within the scope of the invention or without departing from present disclosure, spirit and scope, change, combination or the replacement that the present invention is carried out, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 capsule
Prescription: Semen Cuscutae 15 parts, Radix Rehmanniae Preparata 10 parts, Radix Morindae Officinalis 10 parts, Polyalthia nemoralis A. D C. 15 parts, Herba Taxilli 7 parts, Fructus Schisandrae Chinensis 4 parts, Rhizoma Gymnadeniae 25 parts, Rhizoma Polygonati Odorati 10 parts.
Preparation method: (1) takes Radix Morindae Officinalis, Polyalthia nemoralis A. D C. add medical material amount 5-8 times 50% ethanol water, extract secondary, each 1.5 hours, filtered while hot, be concentrated into and obtain ethanol extraction concentrated solution without alcohol taste；
(2) take Semen Cuscutae, Radix Rehmanniae Preparata, Herba Taxilli, Fructus Schisandrae Chinensis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati together with filtering residue after Radix Morindae Officinalis, Polyalthia nemoralis A. D C. ethanol extraction, add 5-8 times of water soaking 3-4 hour, decoct extraction twice, each 1.0-2.0 hour；Filtered while hot, it is concentrated into relative density 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content be 30% (volume ratio), after standing 24 hours, discard lower sediment thing, obtain supernatant, it is concentrated into relative density 1.05-1.10 (60 DEG C record) to mix with the ethanol extraction concentrated solution of step (1) afterwards, inlet temperature 140～150 DEG C, carry out spray drying under 75～80 DEG C of conditions of leaving air temp and obtain active constituents of medicine, making capsule according to galenic pharmacy routine techniques, every 0.35g, containing crude drug 1.2g.
Embodiment 2 capsule
Prescription: Semen Cuscutae 13 parts, Radix Rehmanniae Preparata 10 parts, Radix Morindae Officinalis 8 parts, Polyalthia nemoralis A. D C. 10 parts, Herba Taxilli 5 parts, Fructus Schisandrae Chinensis 3 parts, Rhizoma Gymnadeniae 20 parts, Rhizoma Polygonati Odorati 8 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 3 capsule
Prescription: Semen Cuscutae 18 parts, Radix Rehmanniae Preparata 12 parts, Radix Morindae Officinalis 10 parts, Polyalthia nemoralis A. D C. 12 parts, Herba Taxilli 7 parts, Fructus Schisandrae Chinensis 3 parts, Rhizoma Gymnadeniae 20 parts, Rhizoma Polygonati Odorati 8 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 4 capsule
Prescription: Semen Cuscutae 15 parts, Radix Rehmanniae Preparata 12 parts, Radix Morindae Officinalis 7 parts, Polyalthia nemoralis A. D C. 10 parts, Herba Taxilli 8 parts, Fructus Schisandrae Chinensis 2.5 parts, Rhizoma Gymnadeniae 20 parts, Rhizoma Polygonati Odorati 8 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 5 capsule
Prescription: Semen Cuscutae 16 parts, Radix Rehmanniae Preparata 12 parts, Radix Morindae Officinalis 8 parts, Polyalthia nemoralis A. D C. 12 parts, Herba Taxilli 6 parts, Fructus Schisandrae Chinensis 3.5 parts, Rhizoma Gymnadeniae 22 parts, Rhizoma Polygonati Odorati 8 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 6 capsule
Prescription: Semen Cuscutae 18 parts, Radix Rehmanniae Preparata 13 parts, Radix Morindae Officinalis 10 parts, Polyalthia nemoralis A. D C. 12 parts, Herba Taxilli 8 parts, Fructus Schisandrae Chinensis 4 parts, Rhizoma Gymnadeniae 29 parts, Rhizoma Polygonati Odorati 12 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 7 tablet
Prescription: Semen Cuscutae 15 parts, Radix Rehmanniae Preparata 12 parts, Radix Morindae Officinalis 10 parts, Polyalthia nemoralis A. D C. 15 parts, Herba Taxilli 6 parts, Fructus Schisandrae Chinensis 3 parts, Rhizoma Gymnadeniae 25 parts, Rhizoma Polygonati Odorati 8 parts.
Preparation method: (1) takes Radix Morindae Officinalis, Polyalthia nemoralis A. D C. add medical material amount 5-8 times 50% ethanol water, extract secondary, each 1.5 hours, filtered while hot, be concentrated into and obtain ethanol extraction concentrated solution without alcohol taste；
(2) take Semen Cuscutae, Radix Rehmanniae Preparata, Herba Taxilli, Fructus Schisandrae Chinensis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati together with filtering residue after Radix Morindae Officinalis, Polyalthia nemoralis A. D C. ethanol extraction, add 5-8 times of water soaking 3-4 hour, decoct extraction twice, each 1.0-2.0 hour；Filtered while hot, it is concentrated into relative density 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content be 30% (volume ratio), after standing 24 hours, discard lower sediment thing, obtain supernatant, it is concentrated into relative density 1.05-1.10 (60 DEG C record) to mix with the ethanol extraction concentrated solution of step (1) afterwards, inlet temperature 140～150 DEG C, carry out spray drying under 75～80 DEG C of conditions of leaving air temp and obtain active constituents of medicine, making tablet according to galenic pharmacy routine techniques, every 0.4g, containing crude drug 1.0g.
Embodiment 8 granule
Prescription: Semen Cuscutae 15 parts, Radix Rehmanniae Preparata 10 parts, Radix Morindae Officinalis 10 parts, Polyalthia nemoralis A. D C. 15 parts, Herba Taxilli 7 parts, Fructus Schisandrae Chinensis 4 parts, Rhizoma Gymnadeniae 25 parts, Rhizoma Polygonati Odorati 10 parts.
Preparation method: (1) takes Radix Morindae Officinalis, Polyalthia nemoralis A. D C. add medical material amount 5-8 times 50% ethanol water, extract secondary, each 1.5 hours, filtered while hot, be concentrated into and obtain ethanol extraction concentrated solution without alcohol taste；
(2) take Semen Cuscutae, Radix Rehmanniae Preparata, Herba Taxilli, Fructus Schisandrae Chinensis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati together with filtering residue after Radix Morindae Officinalis, Polyalthia nemoralis A. D C. ethanol extraction, add 5-8 times of water soaking 3-4 hour, decoct extraction twice, each 1.0-2.0 hour；Filtered while hot, it is concentrated into relative density 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content be 30% (volume ratio), after standing 24 hours, discard lower sediment thing, obtain supernatant, it is concentrated into relative density 1.05-1.10 (60 DEG C record) to mix with the ethanol extraction concentrated solution of step (1) afterwards, inlet temperature 140～150 DEG C, carry out spray drying under 75～80 DEG C of conditions of leaving air temp and obtain active constituents of medicine, making granule according to galenic pharmacy routine techniques, every bag of 3.0g, containing crude drug 5.0g.
Embodiment 9 clinical observation is tested
1 clinical data and method
1.1 physical data: choose the court's kidney yang deficiency syndrome in March ,-2014 in April, 2013 early stage threatened abortion patient, totally 80 example, wherein, first pregnant person 54 example, there are 1 person 20 example of history of spontaneous abortion, 2 person 7 examples, 3 times and above person 3 example；There is history of artificial abortion person 28 example；It is randomly divided into 2 groups, often organizes 42 examples.The treatment group mean age (29.57 ± 5.05) year, pregnant week (8.43 ± 1.88) week；The matched group mean age (30.08 ± 5.78) year, pregnant week (8.37 ± 1.69) week.2 groups of physical data compare, the equal not statistically significant of difference (P > 0.05), have comparability.
1.2 diagnosis marks
1.2.1 Western medicine diagnose standard: " new Chinese medicine guideline of clinical investigations " and happy outstanding 6th edition " obstetrics and gynecology " the early stage threatened abortion diagnostic criteria with reference to the revision in 2002 of national drug food surveillance authority is as follows: 1. have menolipsis history and morning sickness；2. vagina is hemorrhage on a small quantity, or with lower abdomen pendant pain or soreness of waist pain；3. urine pregnancy test is positive；4. cervical orifice is not opened, and body of uterus is soft, size and pregnant Zhou Xiangfu；5. Type B sound wave checks that uterus size, pregnant capsule or embryo (fetus) grow and pregnant Zhou Xiangfu.
1.2.2 Syndrome Differentiation of Traditional Chinese Medicine standard: " new Chinese medicine guideline of clinical investigations " and Ou Yanghui minister in ancient times the 1st edition " Gynecology of Chinese Medicine " with reference to the revision in 2002 of national drug food surveillance authority are formulated: main symptom: vagina is hemorrhage on a small quantity, matter is clear, color is light, lower abdomen pendant pain, soreness of waist pain；Two knees soreness；Secondary card: with dizziness and tinnitus, nocturia, or once had induced abortion repeatly, eye socket is pitch-dark or has facial dim speckle；Tongue arteries and veins: pale tongue, tongue is white, and deep-thready pulse is slightly sliding.Note: above syndrome main symptom is indispensable, one of adds item or two cards and namely tongue fur pulse condition is made a definite diagnosis.
1.3 case inclusive criterias: with reference to " the new Chinese medicine guideline of clinical investigations " of the revision in 2002 of national drug food surveillance authority: during (1) meets, Western medicine diagnose standard；(2) this researcher is accepted voluntarily；(3) age is between 22～40 years old.
1.4 case exclusion standards: " new Chinese medicine guideline of clinical investigations " (1) age > 40 years old or < of reference national drug food surveillance authority revision in 2002 22 years old；(2) primary disease Western medicine diagnose standard and TCM syndrome diagnostic criteria are not met；(3) merge intentionally, brain, liver, the serious disease patient such as kidney and hemopoietic system；(4) cannot partner, as being associated with nerve, mental disease, or be reluctant partner；(5) eliminating and chromosomal abnormality, genitals anatomical factors, endocrine factors, genital infection, blocking antibody exception, extraneous undesirable element etc. cause the patient of early stage threatened abortion.
1.5 Therapeutic Method:
Treatment group: the capsule of the oral embodiment of the present invention 1 preparation, every day 2 times, each 2-4 grain, takes after meal half an hour.
Matched group: chorionic-gonadotropin hormone 1000U, the next day intramuscular injection, Progesterone soft gelatin capsule 200mg, 1 time every night.
Advise patient to note lying up, it is to avoid tired, prohibit sexual life, have the balanced diet, nutritious food, supplements the various nutrient substance that gestation is required；Emotion regulation, keeps happy, it is to avoid direct stimulation, positive partner treatment.It is 1 course for the treatment of that two groups of patients treat 7 days all continuously, altogether 2 courses for the treatment of of treatment.
1.6 observation index:
1.6.1 the index symptom before and after patient treatment, sign change are observed；Symptom score standard carries out according to " new Chinese medicine guideline of clinical investigations (tries) ": vaginal hemorrhage: bleeding time >=within 7 days, it is 3 points；4-6 days bleeding time was 2 points, within≤3 days, was 1 point；Hemorrhage continue unclean, it is necessary to packing paper is 3 points, and hemorrhage dripping difficulty is clean, and amount is 2 points less, hemorrhage cuts in and out, drop and under be 1 point；All the other symptoms according to degree without, light, in, heavily classification, its corresponding score value respectively 0,1,2,3 points, every symptom score sum is total score, and total score has 24 points, and score is more high, then symptom is more heavy.
1.6.2B super monitoring fetal development situation, detects serum endocrine: Serum HCG, progesterone, estradiol, immune indexes etc..
1.7 efficacy assessment standards: according to " Chinese medical disease Standardization of diagnosis and curative effect " and " new Chinese medicine guideline of clinical investigations " threatened abortion criterion of therapeutical effect: clinical cure: after treatment, vaginal hemorrhage stops, stomachache soreness of waist transference cure, uterus size and pregnant Zhou Xiangfu, ultrasound diagnosis fetal development is normal.Effective: after treatment, vaginal hemorrhage stops, stomachache soreness of waist symptom is obviously improved, and syndrome integral reduces >=70%, uterus size and pregnant Zhou Xiangfu, and ultrasound diagnosis fetal development is normal.Effective: after treatment, vaginal hemorrhage stops, stomachache soreness of waist symptom makes moderate progress, and syndrome integral reduces >=30%, uterus size and pregnant Zhou Xiangfu, and ultrasound diagnosis fetal development is normal.Invalid: colporrhagia after treatment, stomachache soreness of waist symptom ditto or increase the weight of, final inevitable abortion.Therapeutic index (N) computing formula (nimodipine method): N=[before (before treatment integration after integration-treatment)/treatment integration] X100%
2 results
The comparison of 2.1 liang of clinical total effectses of group: treatment group cures 21 examples, effective 11 examples, effective 5 examples, invalid 3 examples, matched group cures 8 examples, effective 8 examples, effective 13 examples, invalid 11 examples, treatment group and matched group total effective rate respectively 92.5% and 72.5%, two groups of total effective rate comparing differences statistically significant (P < 0.05), the curative effect for the treatment of group is substantially better than matched group.In Table 1.
The comparison of the clinical total effects of 1 liang of table group
Note: compare with matched group, * P < 0.05.
Before and after 2.2 liang of group treatments, TCM symptom score compares: after the treatment for the treatment of group, TCM symptom score is all substantially more less than before treatment, with comparing difference statistically significant (P < 0.01) before treatment, matched group compares with before treatment, difference statistically significant (P < 0.05)；Comparing between two groups after treatment, treatment group is better than matched group in improving tcm symptom, and the minimizing for the treatment of group symptom integral becomes apparent from, difference statistically significant (P < 0.01).In Table 2.
Before and after the group treatment of 2 liang of table, TCM symptom score compares
Note: compare with before treatment, * P < 0.05, * * P < 0.01；Compare the same period with matched group,#P < 0.01.
2.3 safety conditions: routine blood test, routine urinalysis, electrocardiogram change without exception before and after treatment group patient treatment, in therapeutic process, vital sign is steadily and without the untoward reaction such as nausea and vomiting, allergy, illustrates that our clinical application is safe and reliable.
In a word, compatibility of drugs of the present invention is precise and appropriate rationally, and treatment kidney yang deficiency syndrome early stage threatened abortion patient kidney-replenishing spleen invigorating again can adjust liver, and therapeutic effect is substantially better than Western medicine therapy, show Chinese medicine huge advantage in treatment early stage threatened abortion, be worth studying application further.
Model case:
Wang, female, 27 years old, professional is married.The first visit date: on May 9th, 2013；Patient's companion's stomachache vomiting in pregnant 47 days is gone to a doctor for 3 days, and it is frequent that patient states nausea and vomiting within the next few days, eats and namely tells, and with lower abdomen pain, vagina hemorrhage 3 days on a small quantity, color is light red, and early pregnancy is shown in ultrasound diagnosis, in utero sees a small amount of embryonic tissue, has no heart pipe and beats.Stool is few, nocturia；Light red tongue white and thin fur, deep pulse is fine and smooth, and Western medicine diagnose is early stage threatened abortion, and differential diagnosis in tcm diagnosis is insufficiency of kidney-YANG；Taking the capsule of embodiments of the invention 1, every day 2 times, each 4, after patient takes medicine one week, colporrhagia stops, and not bitterly, nocturia number of times reduces lower abdomen.Following the service is checked B ultrasonic and is shown and in utero see pregnant capsule after one week, see that heart pipe is beaten.Follow up a case by regular visits to patient's term birth one girl baby's body to be good for.
Wu, female, 35 years old, civil servant is married.The first visit date: on October 21st, 2013；Pregnant 52 days companion's vaginas of patient are gone to a doctor on a small quantity for hemorrhage 5 days, and patient tells habitual abortion 3 times, arises that vaginal hemorrhage about each pregnant February, ultrasound diagnosis embryo stasi after January.Early pregnancy is shown in this time ultrasound diagnosis, in utero sees that pregnant capsule and heart pipe are beaten.Vaginal hemorrhage color, amount is few, accompanies lower abdomen dull pain, the soreness of waist, Na Gu still can, frequent urination at night.Pale tongue with thin fur, thready and rolling pulse.Western medicine diagnose is early stage threatened abortion, and differential diagnosis in tcm diagnosis is insufficiency of kidney-YANG；Taking the capsule of the embodiment of the present invention 2, every day 2 times, each 4, after patient takes medicine 5 days, blood is only；Advise absolute bed rest, following the service one week, check B ultrasonic after January and show that fetal growth retardation is survived.Follow up a case by regular visits to patient's term birth one girl baby's body to be good for.
Claims (10)
1. the pharmaceutical composition treating kidney yang deficiency syndrome early stage threatened abortion, it is characterised in that be that medicinal raw material is made by Semen Cuscutae, Radix Rehmanniae Preparata, Radix Morindae Officinalis, Polyalthia nemoralis A. D C., Herba Taxilli, Fructus Schisandrae Chinensis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati.
2. the pharmaceutical composition for the treatment of kidney yang deficiency syndrome early stage threatened abortion as claimed in claim 1, it is characterised in that be made up of the medicinal raw material of following weight: Semen Cuscutae 13-18 part, Radix Rehmanniae Preparata 8-13 part, Radix Morindae Officinalis 7-12 part, Polyalthia nemoralis A. D C. 10-15 part, Herba Taxilli 5-8 part, Fructus Schisandrae Chinensis 2.5-4.5 part, Rhizoma Gymnadeniae 20-25 part, Rhizoma Polygonati Odorati 7-12 part.
3. the pharmaceutical composition for the treatment of kidney yang deficiency syndrome early stage threatened abortion as claimed in claim 2, it is characterised in that be made up of the medicinal raw material of following weight: Semen Cuscutae 15 parts, Radix Rehmanniae Preparata 10 parts, Radix Morindae Officinalis 10 parts, Polyalthia nemoralis A. D C. 15 parts, Herba Taxilli 7 parts, Fructus Schisandrae Chinensis 4 parts, Rhizoma Gymnadeniae 25 parts, Rhizoma Polygonati Odorati 10 parts.
4. the pharmaceutical composition of the treatment kidney yang deficiency syndrome early stage threatened abortion as described in as arbitrary in claim 1-3, it is characterised in that preparation method comprises the following steps:
(1) take Radix Morindae Officinalis, Polyalthia nemoralis A. D C. add medical material amount 5-8 times 50% ethanol water, extract secondary, each 1.5 hours, filtered while hot, be concentrated into and obtain ethanol extraction concentrated solution without alcohol taste；
(2) take Semen Cuscutae, Radix Rehmanniae Preparata, Herba Taxilli, Fructus Schisandrae Chinensis, Rhizoma Gymnadeniae, Rhizoma Polygonati Odorati together with filtering residue after Radix Morindae Officinalis, Polyalthia nemoralis A. D C. ethanol extraction, add 5-8 times of water soaking 3-4 hour, decoct extraction twice, each 1.0-2.0 hour；Filtered while hot, it is concentrated into relative density 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content be 30% (volume ratio), after standing 24 hours, discard lower sediment thing, obtain supernatant, be concentrated into relative density 1.05-1.10 (60 DEG C record) and mix with the ethanol extraction concentrated solution of step (1) afterwards, under inlet temperature 140～150 DEG C, 75～80 DEG C of conditions of leaving air temp, carry out spray drying obtain active constituents of medicine；This composition individually or mixes with pharmaceutically acceptable carrier, makes according to galenic pharmacy routine techniques.
5. the pharmaceutical composition for the treatment of kidney yang deficiency syndrome early stage threatened abortion as claimed in claim 4, it is characterised in that described pharmaceutical composition can be prepared as dosage form conventional clinically.
6. the pharmaceutical composition for the treatment of kidney yang deficiency syndrome early stage threatened abortion as claimed in claim 5, it is characterised in that the dosage form of described pharmaceutical composition is preferably peroral dosage form.
7. the pharmaceutical composition for the treatment of kidney yang deficiency syndrome early stage threatened abortion as claimed in claim 6, it is characterised in that described peroral dosage form is preferably powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, tablet, capsule etc..
8. the pharmaceutical composition for the treatment of kidney yang deficiency syndrome early stage threatened abortion as claimed in claim 7, it is characterised in that described peroral dosage form is preferably granule, tablet or capsule.
9. the pharmaceutical composition for the treatment of kidney yang deficiency syndrome early stage threatened abortion as claimed in claim 8, it is characterised in that described peroral dosage form is preferably capsule.
10. the purposes in preparation treatment kidney yang deficiency syndrome early stage threatened abortion medicine of the pharmaceutical composition as described in as arbitrary in claim 1-3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610183867.4A CN105726970A (en) | 2016-03-28 | 2016-03-28 | Medicine composition for treating early threatened abortion caused by deficiency of kidney yang |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610183867.4A CN105726970A (en) | 2016-03-28 | 2016-03-28 | Medicine composition for treating early threatened abortion caused by deficiency of kidney yang |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105726970A true CN105726970A (en) | 2016-07-06 |
Family
ID=56252163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610183867.4A Withdrawn CN105726970A (en) | 2016-03-28 | 2016-03-28 | Medicine composition for treating early threatened abortion caused by deficiency of kidney yang |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105726970A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406664A (en) * | 2008-12-09 | 2009-04-15 | 陕西东泰制药有限公司 | Chinese medicament preparation for tocolysis and preparation method thereof |
| CN103071105A (en) * | 2013-02-06 | 2013-05-01 | 孙迎春 | External traditional Chinese medicinal preparation for treating threatened abortion and preparation method thereof |
| CN103751480A (en) * | 2014-01-21 | 2014-04-30 | 于信香 | Traditional Chinese medicine for treating habitual abortion |
| CN105288056A (en) * | 2015-12-03 | 2016-02-03 | 广东伊茗药业有限公司 | Pharmaceutical composition for treating threatened abortion and preparation method of pharmaceutical composition |
-
2016
- 2016-03-28 CN CN201610183867.4A patent/CN105726970A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406664A (en) * | 2008-12-09 | 2009-04-15 | 陕西东泰制药有限公司 | Chinese medicament preparation for tocolysis and preparation method thereof |
| CN103071105A (en) * | 2013-02-06 | 2013-05-01 | 孙迎春 | External traditional Chinese medicinal preparation for treating threatened abortion and preparation method thereof |
| CN103751480A (en) * | 2014-01-21 | 2014-04-30 | 于信香 | Traditional Chinese medicine for treating habitual abortion |
| CN105288056A (en) * | 2015-12-03 | 2016-02-03 | 广东伊茗药业有限公司 | Pharmaceutical composition for treating threatened abortion and preparation method of pharmaceutical composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105412787A (en) | Medicine for treating postpartum irregular menstruation | |
| CN104435519A (en) | Pharmaceutical composition for treating primary dysmenorrhea | |
| CN104523889B (en) | A kind of Chinese medicine preparation for the treatment of habitual abortion and preparation method thereof | |
| CN104784538B (en) | A kind of Chinese medicine preparation and preparation method for the treatment of diabetes | |
| CN101607067B (en) | Traditional Chinese medicine preparation for treating cholelithiasis and preparation method thereof | |
| CN100540030C (en) | A kind of topical agent for the treatment of dysmenorrhes | |
| CN104771695A (en) | Ovulation promoting traditional Chinese medicine for treating female infertility | |
| CN104056173A (en) | Traditional Chinese medicine composition for treating qi and blood deficiency of pregnant women in gestation period | |
| CN104906526A (en) | Chinese medicine preparation for premature ovarian failure and preparation method of Chinese medicine preparation | |
| CN104352867A (en) | Traditional Chinese medicine composition for treating gestational depression | |
| CN109674974A (en) | One kind, which invigorates the kidney and stops nocturnal emission, supports first plaster and preparation method thereof | |
| CN105726970A (en) | Medicine composition for treating early threatened abortion caused by deficiency of kidney yang | |
| CN108653373A (en) | A kind of ginseng Tu parasitism cream of external application and preparation method thereof | |
| CN102357179B (en) | Medicine for treating antisperm antibody induced infertility or habitual abortion and preparation method thereof | |
| CN110090271B (en) | Traditional Chinese medicine composition for treating male infertility, preparation and application thereof | |
| CN102274472A (en) | Traditional Chinese medicine patch for treating female dysmenorrhoea and preparation thereof | |
| CN105560668A (en) | Pharmaceutical composition for curing immune infertility | |
| CN105726868A (en) | Pharmaceutical preparation for treating first-trimester threatened abortion with anticardiolipin antibody positive | |
| CN105748718A (en) | Pharmaceutic preparation for treating recurrent spontaneous abortion caused by blocking antibody deficiency | |
| CN105477264A (en) | Medicinal preparation for treating urethral syndrome | |
| CN105535466A (en) | Pharmaceutical composition for treating pubescent polycystic ovarian syndrome | |
| CN118593644A (en) | Traditional Chinese medicine compound for treating phlegm-dampness stagnation type gonarthromeningitis and application thereof | |
| CN105250869A (en) | Menstruation regulating ointment for treating abnormal menstruation and preparing method of menstruation regulating ointment | |
| CN100525808C (en) | Chinese traditional medicine compound took orally for treating metropathia hemorrhagica | |
| CN104547989A (en) | Tibetan paste for treating spondylodynia and using method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160706 |
|
| WW01 | Invention patent application withdrawn after publication |