CN105726854A - Traditional Chinese medicine preparation for treating chronic heart failure and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine preparation for treating chronic heart failure and a preparation method thereof. The traditional Chinese medicine preparation is prepared from following raw materials, by weight, 10-15 parts of panax notoginseng, 15-20 parts of salviae miltiorrhizae, 10-15 parts of prepared rehmannia roots, 3-5 parts of herba cistanche, 3-5 parts of cyperus rotundus, 3-5 parts of cornus officinalis, 1-2 parts of fructus lycii, 2-3 parts of dragon bone, 10-15 parts of apocynum venetum, 3-5 parts of cortex moutan, 5-8 parts of rhizoma chuanxiong, 5-10 parts of herba leonuri and 2-3 parts of rhizoma curculiginis. The traditional Chinese medicines satisfy the specifications in Chinese pharmacopoeia, are safe and reliable, and are combined together to achieve the effects of tonifying and boosting heart qi, activating blood to resolve stasis, promoting dieresis and resolving phlegm. The preparation has definite curative effects on the chronic heart failure, is quick in effects, is high in curative ratio and is free of side effects.

Description

Chinese medicine preparation for the treatment of chronic heart failure and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation treating chronic heart failure and preparation method thereof.

Background technology

Chronic heart failure (CHF) is serious or the end stage eventually a kind of clinical syndrome of various heart disease.The common cause causing CHF is coronary heart disease, hypertension, diabetes and various cardiomyopathys etc., and the heart failure that wherein coronary heart disease causes accounts for first place.

The M & M of CHF remains high, and has close relationship with the clinical course of CHF.2007 China's " diagnosis of chronic congestive heart failure and treatment guidelines " and the Heart failure guide of 2005 U.S. all point out that CHF is a kind of progressive pathological changes, once initiate, even without new cardiac damage, clinic is also at the stabilization sub stage, but still self development.Therefore, U.S.'s heart failure writes the new method of committee's initiative development heart failure classification, and by its order of severity, heart failure is divided into A, B, C, D four-stage.Stage A is " front heart failure stage " (Pre-HeartFailure), the structure of this stage acardia or dysfunction, also without the symptom of heart failure and (or) sign.Being more common in the population at risk occurred frequently (referring mainly to hypertension, coronary heart disease, diabetes etc.) of heart failure, the heart failure in this stage can prevent.Stage B belongs to " front clinical heart failure stage " (Pre-ClinicalHeartFailure), patient has evolved into structural heart disease from symptom and (or) the sign without heart failure, for instance: left ventricular hypertrophy, asymptomatic valvular heart disease, there is MI (myocardial infarction) history etc. in the past.This stage is equivalent to silent heart failure or NYHA cardiac function I grade.Owing to heart failure is a kind of progressive pathological changes, but myocardial remodelling self constantly develops, and therefore, this stage active treatment of patient is of crucial importance, and treat it is crucial that block or delay myocardial remodelling.Stage C is the clinical heart failure stage.The structural heart disease on the existing basis of patient, has symptom and (or) the sign of heart failure in the past or at present；Though or at present without the symptom of heart failure and (or) sign, but once therefore treated in the past.This stage includes NYHA II, III grade and IV grade of cardiac function patient of part.Stage D is the intractable whole heart failure stage in latter stage.Patient has Progressive symmetric erythrokeratodermia structural heart disease, though through positive medical treatment, still having symptom, and need special intervention during rest.

As can be seen here, for heart failure stage B, before the symptoms of heart failure of myocardial infarction or left ventricular hypertrophy patient occurs, early stage takes remedy measures, it is possible to decrease the M & M of heart failure.

Chinese medicine is cured the disease in process long-term, have accumulated rich experience.Without the name of " heart failure " in traditional Chinese medical science traditional literature, according to its Clinical symptoms, relate to the categories such as the traditional Chinese medical science " the syndrome of dyspnea ", " edema ", " cardiopalmus ", " palpitation with a distress feeling ", " phlegm retention ", " obstruction of heart-QI ".Great majority research is thought, primary disease belongs to the card of deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive, declines for this with motive deficiency of heart-YANG, and the blood vessels stasis of blood is stagnant, fluid-retention stagnating in the interior, expectorant are turbid does not turn to mark.

In recent years, the sickness rate of heart failure and case fatality rate present the trend of constantly rising, and consequent medical expense and burden on society also increase sharply, and within 2005, U.S.'s CHF patient reaches 5,500,000, are used directly or indirectly in the expense for the treatment of CHF up to 27,900,000,000 dollars.China's result to urban and rural residents' totally 15518 people's random sampling in 35～74 years old: heart failure prevalence is 0.9%, there are about 4,000,000 patients with heart failure by calculating, and wherein male is 0.7%, and women is 1.0%.Framingham studies display, CHF5 annual survival rate, and male is 25%, and women is 38%, and patient with severe symptoms was generally survived less than 1 year.According to 42, China some areas hospital, 3 annual sections in 1980,1990,2000, to the heart failure inpatient Retrospective review that totally 10714 examples are made, in the cause of disease, coronary heart disease is risen to 45.6% in 2000 by 36.8% in 1980, occupies first of the various cause of disease；15 hospitals totally 3169 patients with heart failure in 8 cities have been investigated by one research of the Japan adjacent with China, it has been found that hat

Cardiopathia also accounts for space of top prominence (33.5%) in the heart failure cause of disease；Framingham studies discovery, when the age by 40 years old time, crowd occurs the danger of heart failure substantially to increase (male: 21%, women: 20%), and this danger and myocardial ischemia and blood pressure level are closely related.

The conventional medicament for the treatment of CHF mainly includes diuretic, ACEI (angiotensin converting enzyme inhibitor) class, vasodilation, cardiac tonic, Myocardial nutrient, calcium channel blocker etc., but fundamentally do not improve the quality of life of patient, also fail to effectively reduce the mortality rate of CHF, clinical practice there is also problems.Along with the understanding that CHF occurs and develops basic pathology mechanism myocardial remodelling, traditional heart tonifying, diuresis, expansion blood vessel conventional therapy theory progressively desalinate, improve symptom from the pharmaceutical practice of short-term, be gradually converted into strategy long-term, prosthetic and to the pathogenetic intervention of CHF.

Summary of the invention

According to above the deficiencies in the prior art, the present invention provides a kind of Chinese medicine preparation treating chronic heart failure and preparation method thereof, and it is evident in efficacy, safe and reliable, have no side effect, and has wide potential applicability in clinical practice.

A kind of Chinese medicine preparation treating chronic heart failure of the present invention, according to parts by weight meter, formulated by following raw material of Chinese medicine: Radix Notoginseng 10～15 parts, Radix Salviae Miltiorrhizae 15～20 parts, Radix Rehmanniae Preparata 10～15 parts, Herba Cistanches 3～5 parts, Rhizoma Cyperi 3～5 parts, Fructus Corni 3～5 parts, Fructus Lycii 1～2 part, Os Draconis 2～3 parts, Herba Apocyni veneti 10～15 parts, Cortex Moutan 3～5 parts, Rhizoma Chuanxiong 5～8 parts, Herba Leonuri 5～10 parts and Rhizoma Curculiginis 2～3 parts.

Wherein, it is preferable that scheme is as follows:

According to parts by weight meter, formulated by following raw material of Chinese medicine: Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Rehmanniae Preparata 10 parts, Herba Cistanches 3 parts, Rhizoma Cyperi 3 parts, Fructus Corni 3 parts, Fructus Lycii 1 part, Os Draconis 2 parts, Herba Apocyni veneti 10 parts, Cortex Moutan 3 parts, Rhizoma Chuanxiong 5 parts, Herba Leonuri 5 parts and Rhizoma Curculiginis 2 parts.

Can also according to parts by weight meter, formulated by following raw material of Chinese medicine: Radix Notoginseng 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Rehmanniae Preparata 15 parts, Herba Cistanches 5 parts, Rhizoma Cyperi 5 parts, Fructus Corni 5 parts, Fructus Lycii 2 parts, Os Draconis 3 parts, Herba Apocyni veneti 15 parts, Cortex Moutan 5 parts, Rhizoma Chuanxiong 8 parts, Herba Leonuri 10 parts and Rhizoma Curculiginis 3 parts.

The preparation method of the Chinese medicine preparation for the treatment of chronic heart failure of the present invention, prepare in accordance with the following methods: weigh raw material of Chinese medicine according to formula and join in container, add water and cover powder immersion 10～20 minutes, add water and do not have powder 3～5 centimetres, decoct with high heat and use slow fire boiling again instead 20～30 minutes to boiling, take filtrate；Then adding water and do not have powder 3～5 centimetres, decoct with high heat and use slow fire boiling again instead 15～20 minutes to boiling, then removing slag takes filtrate, and twice filtrate merges.

During use, each 200～300ml, sooner or later respectively once.

Pharmacology analysis:

Radix Notoginseng: sweet micro-hardship, temperature, nontoxic.Enter liver, stomach, double enter the heart, large intestine.Hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.Root is used as medicine, and containing TANSHINONES, for robustness emmenagogue, has blood stasis dispelling, tissue regeneration promoting, invigorates blood circulation, the effectiveness such as regulating menstruation, for gynecological's key medicine, cures mainly metrorrhagia, menoxenia, blood stasis, stomachache, dysmenorrhoea, amenorrhea, mausoleum pain.Treatment coronary heart disease there is good result.In addition also controlling the weak insomnia of nerve, arthralgia, anemia, mastitis, lymphadenitis, arthritis, furuncle pain is swollen, erysipelas, acute, chronic hepatitis, nephropyelitis, traumatic injury, and advanced schistosomiasis hepatosplenomegaly is insane.

Radix Rehmanniae Preparata: sweet in the mouth；Warm in nature.Return liver；Kidney channel.Enrich blood moist；Benefit essence fills out marrow；For blood deficiency and yellow complexion；Dizziness cardiopalmus；Menoxenia；Collapse more than；Hepatic and renal YIN deficiency；Hectic fever night sweat；Seminal emission sexual impotence；Infertility；Menoxenia；Metrostaxis；Soreness of the waist and knees；Hiccough and deaf；The head is dim-sighted；Early whitening of beard and hair；Quench one's thirst；Constipation；Suffer from a deficiency of the kidney dyspnea with rapid and short breath.Modern study, the Dihuang polysaccharide contained by Radix Rehmanniae Preparata has significantly immunity antitumor activity, also have significant heart tonifying, diuresis, protect the liver, blood sugar lowering, anti-proliferate, exudation, antiinflammatory, antifungal, the effect such as anti-radiation.

Herba Cistanches: sweet in the mouth；Salty；Warm in nature.Return kidney；Large intestine channel.Kidney-replenishing；Benefiting essence-blood；Intestine moistening road.Main kidney yang deficiency；The sexual impotence of asthenia of essence and blood；Seminal emission；Nebulousurine；The frequent micturition heeltap；Lumbago flaccidity of the lower limbs；Tinnitus order flower；Menstruation is spread out the phase；Infertility；Dryness of the intestine constipation.Herba Cistanches has a degree of anti-aging effects.Herba Cistanches can make the activity of mouse red blood cell superoxide dismutase (SOD) be remarkably reinforced, and makes mouse cardiac muscle lipofuscin content substantially reduce.Also the average life of fruit bat, median lethal natural law and maximum life span can be extended.Herba Cistanches water decoction 8g/kg, to mouse stomach, can significantly raise erythrocyte membrane Na⁺、K⁺-atpase activity, one of this mechanism being probably its benefiting action.

Rhizoma Cyperi: pungent micro-hardship is sweet is flat.Enter liver, tri-jiao channel.Regulate the flow of vital energy resolving depression；Menstruction regulating and pain relieving；Antiabortive.Main distending pain over the hypochondrium；Mammary swelling is educated；Hernia pain；Menoxenia；Gastral cavity abdomen feeling of fullness pain；Belch acid regurgitation, vomiting and nausea；Abdominal pain during menstruation；Bleeding not during menses；Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Fructus Corni: sour, puckery, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.

Fructus Lycii: sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.

Os Draconis: sweet puckery are flat.Enter the heart, liver, kidney, large intestine channel.Tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, stop blooding astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Controlling infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, stranguria with turbid discharge of passing out semen, and tells nosebleed and has blood in stool, and bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.

Herba Apocyni veneti: sweet-bitter flavor, property is put down, slightly poisonous.Return Liver Channel.Suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria；Hypertension, neurasthenia, nephritis edema.In root of Apocynum venetum L., the cat heart in vitro and in place all can be made its shrinkage amplitude increase by contained cymarin, heart rate is slack-off, then arrhythmia, and heart beating finally stops at systole, the central depressants such as its interaction property is similar to strophanthin with speed, pentobarbital sodium can weaken its cardiotonic.With root of Apocynum venetum L. extract, the cat heart in place is tested, also performance cardiotonic glycoside sample effect.

Cortex Moutan: arduous；Cool；It is slightly cold.GUIXIN；Liver；Kidney；Lung meridian.Heat clearing away；Promoting blood circulation to remove blood stasis.Control the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases；Send out speckle；Tell nosebleed；Pathogenic bacteria later stage brimful of tears hot Fu Yin distribution heat；Deficiency of YIN osteopyrexia and fever；Amenorrhea due to stagnation of blood；Dysmenorrhea；Carbuncle sore tumefacting virus；Fall and flutter the pain of injury；Beriberoid pyretic arthralgia.

Rhizoma Chuanxiong: warm in nature, returns liver, gallbladder, heart channel, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, and the pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go scattered, up up to top, mountain peak；Enter again blood system, descending up to the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is the gas medicine in blood that former times people calls Rhizoma Chuanxiong, the function such as its residence of dangerous speech is pungent to be dissipated, resolving depression, sensible, pain relieving.

Herba Leonuri: acrid in the mouth is bitter, cool, invigorates blood circulation, silt of dispelling, regulating menstruation, disappear water, treats menoxenia, and vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Herba Leonuri can promote the quickly recovery of the regional flow's microcirculation disturbance caused by isoproterenol.Isoproterenol 50 mg/kg, it is downright bad that subcutaneous injection manufactures myocardial ischemia in rats；The low electrocardiogram with T wave height of T wave pressure is selected after 24 hours, two-phase T ripple electrocardiogram is selected after 4 days, treat with motherwort formulation, result is in treatment 1 hour, the electrocardiogram of major part animal all recovers normal, show cardiac muscle early stage ischemia (24 hours) even pathological changes, close to ischemic necrosis.

Rhizoma Curculiginis: pungent, heat；Poisonous.Return kidney,liver,spleen warp.Kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness.For sexual impotence cold sperm, muscles and bones flaccidity is soft, the cold numbness of waist knee joint, yang deficiency cold diarrhea.The expansible arteria coronaria of Rhizoma Curculiginis aqueous extract, heart tonifying.Give slow arrhythmia rabbit vein injection 6g/kg, can dramatically increase heart rate, mutant cell digital display is made decline, make the system converting inhibition of enzyme activity of purine about 20%, making cholecystokinin suppress about 80%, make hypothyroidism, the cyclic adenosine monophosphate-C-AMP level reduction person of patients serum is gone up, cyclic guanosine monophosphate level rising person returns and drops, and cyclic adenosine monophosphate-C-AMP/cyclic guanosine monophosphate ratio tends to normal.

It is an advantage of the current invention that the Chinese medicine used meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable.All medicine phases and there is the tonification motive, effect, the features such as treatment chronic heart failure has determined curative effect, instant effect, cure rate is high, have no side effect such as blood circulation promoting and blood stasis dispelling, diuretic reduce phlegm.

Outcome measure:

1, case selection:

As treatment chronic heart failure medicine, select chronic heart failure 100 example carry out clinical observation, wherein male 66 examples, women 34 example, age 45-85 year, 62 years old mean age, course of disease 1-10, average 2.4 years.

2, medicine for treatment:

Treatment group patient takes medicine of the present invention, each 200～300ml, sooner or later each once within 7 days, be a course for the treatment of, take continuously 3-4 the course for the treatment of according to the state of an illness, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.

3, Outcome measure:

According to USA New York cardiology meeting heart failure grade scale (NYHA classification), without heart failure person BNP<80ng/L, I grade of person BNP95～221ng/L of cardiac function, II grade of patient B NP221～459ng/L of cardiac function, Ⅲcardiac function patient B NP459～1006ng/L, IV grade of patient B NP>=1006ng/L of cardiac function.At present, in the world the positive threshold value of patients with heart failure BNP is decided to be 100ng/L, when BNP measured value is below normal value, it is believed that heart failure can be got rid of.

Effective: clinical symptoms disappears substantially, test chamber checks that each index of correlation is close to normal level, BNP < 100ng/L.

Effective: clinical symptom relief, test chamber checks that each index of correlation makes moderate progress, and NYHA classification promotes to improvement direction, and sign has improvement.

Invalid: clinical symptoms is without being clearly better or increasing the weight of.

4, therapeutic outcome:

Effective 42 examples, effective 51 examples, invalid 7 examples, total effective rate is 93%.

It is exemplified below a model case:

Zhang, man, 67 years old, people from Qingdao, in more than 10 years of chronic heart failure, heart rate 95 beats/min, blood pressure 135/72mmHg, cardiac function NYHA III grade, dyspnea, left cardiac ejection fraction 35%, 24h urine volume was about 550ml, hydrosarca, body weight 80.7kg.Before treatment, 24h furosemide consumption 1200mg and spironolactone consumption are 120mg, blood urea nitrogen 21.8mmol/l, serum creatinine 385.6mmol/l, often occur that blood electrolyte is disorderly.When taking first course for the treatment of of invention formulation, heart rate 80 beats/min, cardiac function is improved as II grade, left cardiac ejection fraction 50%, and body weight is 71kg, day urine volume be about 1500ml, blood pressure 130/70mmHg, dyspnea and edema are obviously improved.Following up a case by regular visits to second course for the treatment of, These parameters is improved further, and patients ' life quality is greatly improved.

Detailed description of the invention

Below in conjunction with embodiment, the present invention will be further described.

Embodiment 1:

A kind of Chinese medicine preparation treating chronic heart failure, according to parts by weight meter, formulated by following raw material of Chinese medicine: Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Rehmanniae Preparata 10 parts, Herba Cistanches 3 parts, Rhizoma Cyperi 3 parts, Fructus Corni 3 parts, Fructus Lycii 1 part, Os Draconis 2 parts, Herba Apocyni veneti 10 parts, Cortex Moutan 3 parts, Rhizoma Chuanxiong 5 parts, Herba Leonuri 5 parts and Rhizoma Curculiginis 2 parts.

Embodiment 2:

: a kind of Chinese medicine preparation treating chronic heart failure, according to parts by weight meter, formulated by following raw material of Chinese medicine: Radix Notoginseng 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Rehmanniae Preparata 15 parts, Herba Cistanches 5 parts, Rhizoma Cyperi 5 parts, Fructus Corni 5 parts, Fructus Lycii 2 parts, Os Draconis 3 parts, Herba Apocyni veneti 15 parts, Cortex Moutan 5 parts, Rhizoma Chuanxiong 8 parts, Herba Leonuri 10 parts and Rhizoma Curculiginis 3 parts.

Embodiment 3:

Formula described in embodiment 1 prepares the Chinese medicine preparation for the treatment of chronic heart failure in accordance with the following methods: weighs raw material of Chinese medicine according to formula and joins in container, add water and cover powder immersion 10 minutes, add water and do not have powder 3 centimetres, decoct with high heat and use slow fire boiling again instead 20 minutes to boiling, take filtrate；Then adding water and do not have powder 3 centimetres, decoct with high heat and use slow fire boiling again instead 15 minutes to boiling, then removing slag takes filtrate, and twice filtrate merges.

Embodiment 4:

Formula described in embodiment 2 prepares the Chinese medicine preparation for the treatment of chronic heart failure in accordance with the following methods: weighs raw material of Chinese medicine according to formula and joins in container, add water and cover powder immersion 20 minutes, add water and do not have powder 5 centimetres, decoct with high heat and use slow fire boiling again instead 30 minutes to boiling, take filtrate；Then adding water and do not have powder 5 centimetres, decoct with high heat and use slow fire boiling again instead 20 minutes to boiling, then removing slag takes filtrate, and twice filtrate merges.

Claims (4)

1. the Chinese medicine preparation treating chronic heart failure, it is characterized in that according to parts by weight meter, formulated by following raw material of Chinese medicine: Radix Notoginseng 10～15 parts, Radix Salviae Miltiorrhizae 15～20 parts, Radix Rehmanniae Preparata 10～15 parts, Herba Cistanches 3～5 parts, Rhizoma Cyperi 3～5 parts, Fructus Corni 3～5 parts, Fructus Lycii 1～2 part, Os Draconis 2～3 parts, Herba Apocyni veneti 10～15 parts, Cortex Moutan 3～5 parts, Rhizoma Chuanxiong 5～8 parts, Herba Leonuri 5～10 parts and Rhizoma Curculiginis 2～3 parts.

2. the Chinese medicine preparation for the treatment of chronic heart failure according to claim 1, it is characterized in that according to parts by weight meter, formulated by following raw material of Chinese medicine: Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Rehmanniae Preparata 10 parts, Herba Cistanches 3 parts, Rhizoma Cyperi 3 parts, Fructus Corni 3 parts, Fructus Lycii 1 part, Os Draconis 2 parts, Herba Apocyni veneti 10 parts, Cortex Moutan 3 parts, Rhizoma Chuanxiong 5 parts, Herba Leonuri 5 parts and Rhizoma Curculiginis 2 parts.

3. the Chinese medicine preparation for the treatment of chronic heart failure according to claim 1, it is characterized in that according to parts by weight meter, formulated by following raw material of Chinese medicine: Radix Notoginseng 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Rehmanniae Preparata 15 parts, Herba Cistanches 5 parts, Rhizoma Cyperi 5 parts, Fructus Corni 5 parts, Fructus Lycii 2 parts, Os Draconis 3 parts, Herba Apocyni veneti 15 parts, Cortex Moutan 5 parts, Rhizoma Chuanxiong 8 parts, Herba Leonuri 10 parts and Rhizoma Curculiginis 3 parts.

4. the preparation method of the Chinese medicine preparation of the treatment chronic heart failure described in a claim 1, it is characterized in that preparing in accordance with the following methods: weigh raw material of Chinese medicine according to formula and join in container, add water and cover powder immersion 10～20 minutes, add water and do not have powder 3～5 centimetres, decoct with high heat and use slow fire boiling again instead 20～30 minutes to boiling, take filtrate；Then adding water and do not have powder 3～5 centimetres, decoct with high heat and use slow fire boiling again instead 15～20 minutes to boiling, then removing slag takes filtrate, and twice filtrate merges.