CN104547398A - Traditional Chinese medicine preparation for treating chronic heart failure and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating chronic heart failure and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine preparation for treating chronic heart failure and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-15 parts of pseudo-ginseng, 15-20 parts of radix salviae miltiorrhizae, 10-15 parts of prepared rehmannia roots, 3-5 parts of desertliving cistanche, 3-5 parts of cyperus rotundus linn, 3-5 parts of asiatic cornelian cherry fruits, 1-2 parts of Chinese wolfberry, 2-3 parts of fossil fragments, 10-15 parts of bluish dogbane, 3-5 parts of cortex moutan, 5-8 parts of ligusticum wallichii, 5-10 parts of motherwort and 2-3 parts of common curculigo rhizomes. The traditional Chinese medicine preparation disclosed by the invention has the advantages that the used traditional Chinese medicines conform to the regulations of the pharmacopoeia of the people's republic of China, and the medicines are safe and reliable. All the medicines are matched to have the efficacies of benefiting heart qi, promoting blood circulation for removing blood stasis, promoting diuresis, resolving phlegm and the like, and the traditional Chinese medicine preparation has the characteristics of precise curative effect, fast effect, high cure rate, zero side effect and the like when being used for treating the chronic heart failure.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of chronic heart failure and preparation method thereof.
Background technology
Chronic heart failure (CHF) is a kind of clinical syndrome that is serious or the end stage eventually of various heart disease.The common cause causing CHF is coronary heart disease, hypertension, diabetes and various cardiomyopathys etc., and the heart failure that wherein coronary heart disease causes accounts for first place.
The M & M of CHF remains high, and has close relationship with the clinical course of CHF.The Heart failure guide of 2007 China " diagnosis of chronic congestive heart failure and treatment guidelines " and 2005 U.S. all points out that CHF is a kind of progressive pathological changes, once initial, even without new cardiac damage, is clinically also in the stabilization sub stage, but still self development.Therefore, U.S.'s heart failure writes the new method of committee's initiative development heart failure classification, and heart failure is divided into A, B, C, D four-stage by its order of severity.Stage A is " front heart failure stage " (Pre-Heart Failure), and the structure of this stage acardia or dysfunction, also without symptom and (or) the sign of heart failure.Be more common in the population at risk occurred frequently (mainly referring to hypertension, coronary heart disease, diabetes etc.) of heart failure, the heart failure of this one-phase can prevent.Stage B belongs to " front clinical heart failure stage " (Pre-Clinical HeartFailure), patient develops into structural heart disease from without the symptom of heart failure and (or) sign, such as: left ventricular hypertrophy, asymptomatic valvular heart disease, had MI (myocardial infarction) history etc. in the past.This one-phase is equivalent to silent heart failure, or NYHA cardiac function I grade.Because heart failure is a kind of progressive pathological changes, but myocardial remodelling self constantly develops, and therefore, the active treatment of this one-phase patient is of crucial importance, and the key for the treatment of blocks or delays myocardial remodelling.Stage C is the clinical heart failure stage.Patient has the structural heart disease on basis, has symptom and (or) the sign of heart failure in the past or at present; Though or at present without symptom and (or) the sign of heart failure, once therefore treated in the past.This one-phase comprises NYHA II, III grade and part IV grade of cardiac function patient.Stage D is the intractable whole heart failure stage in latter stage.Patient has Progressive symmetric erythrokeratodermia structural heart disease, though through positive medical treatment, still have symptom during rest, and needs special intervention.
As can be seen here, for heart failure stage B, before the symptoms of heart failure of myocardial infarction or left ventricular hypertrophy patient occurs, take remedy measures in early days, the M & M of heart failure can be reduced.
Chinese medicine is cured the disease in process long-term, have accumulated rich experience.Without the name of " heart failure " in traditional Chinese medical science traditional literature, according to its Clinical symptoms, relate to the category such as the traditional Chinese medical science " the syndrome of dyspnea ", " edema ", " cardiopalmus ", " palpitation with a distress feeling ", " phlegm retention ", " obstruction of heart-QI ".Great majority research is thought, primary disease belongs to the card of deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive, and decline for this with motive deficiency of heart-YANG, the blood vessels stasis of blood is stagnant, fluid-retention stagnating in the interior, expectorant are turbid does not turn to mark.
In recent years, the sickness rate of heart failure and case fatality rate present the trend constantly risen, and consequent medical expense and burden on society also increase sharply, and within 2005, U.S. CHF patient reaches 5,500,000, are directly or indirectly used for the treatment of the expense of CHF up to 27,900,000,000 dollars.China is to the result of 35 ~ 74 years old urban and rural residents totally 15518 people's random sampling: heart failure prevalence is 0.9%, and about have 4,000,000 patients with heart failure by calculating, wherein male is 0.7%, and women is 1.0%.Framingham studies display, CHF5 annual survival rate, and male is 25%, and women is 38%, and patient with severe symptoms was generally survived less than 1 year.According to 42, China some areas hospital, 3 annual sections in 1980,1990,2000, to the heart failure inpatient Retrospective review done of totally 10714 examples, in the cause of disease coronary heart disease by 1980 36.8% rise to 2000 45.6%, occupy first of the various cause of disease; Study for one of the Japan adjacent with China, to 15 hospitals in 8 cities totally 3169 patients with heart failure investigate, find hat
Cardiopathia also accounts for space of top prominence (33.5%) in the heart failure cause of disease; Framingham studies discovery, when the age by 40 years old time, the danger that heart failure occurs crowd obviously increases (male: 21%, women: 20%), and this danger and myocardial ischemia and blood pressure level closely related.
The conventional medicament for the treatment of CHF mainly comprises diuretic, ACEI (angiotensin converting enzyme inhibitor) class, vasodilation, cardiac tonic, Myocardial nutrient, calcium channel blocker etc., but fundamentally do not improve the quality of life of patient, also fail effectively to reduce the mortality rate of CHF, in clinical practice, also there are problems.Along with occurring CHF and development basic pathology mechanism---the understanding of myocardial remodelling, the conventional therapy theory of traditional heart tonifying, diuresis, expansion blood vessel is progressively desalinated, improve symptom from the pharmaceutical practice of short-term, change strategy that is long-term, prosthetic gradually into and to the pathogenetic intervention of CHF.
Summary of the invention
According to above the deficiencies in the prior art, the invention provides a kind of Chinese medicine preparation for the treatment of chronic heart failure and preparation method thereof, it is evident in efficacy, safe and reliable, have no side effect, there is wide potential applicability in clinical practice.
A kind of Chinese medicine preparation for the treatment of chronic heart failure of the present invention, according to weight parts, formulated by following raw material of Chinese medicine: Radix Notoginseng 10 ~ 15 parts, Radix Salviae Miltiorrhizae 15 ~ 20 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, Herba Cistanches 3 ~ 5 parts, Rhizoma Cyperi 3 ~ 5 parts, Fructus Corni 3 ~ 5 parts, Fructus Lycii 1 ~ 2 part, Os Draconis 2 ~ 3 parts, Herba Apocyni veneti 10 ~ 15 parts, Cortex Moutan 3 ~ 5 parts, Rhizoma Chuanxiong 5 ~ 8 parts, Herba Leonuri 5 ~ 10 parts and Rhizoma Curculiginis 2 ~ 3 parts.
Wherein, preferred version is as follows:
According to weight parts, formulated by following raw material of Chinese medicine: Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Rehmanniae Preparata 10 parts, Herba Cistanches 3 parts, Rhizoma Cyperi 3 parts, Fructus Corni 3 parts, Fructus Lycii 1 part, Os Draconis 2 parts, Herba Apocyni veneti 10 parts, Cortex Moutan 3 parts, Rhizoma Chuanxiong 5 parts, Herba Leonuri 5 parts and Rhizoma Curculiginis 2 parts.
Also can according to weight parts, formulated by following raw material of Chinese medicine: Radix Notoginseng 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Rehmanniae Preparata 15 parts, Herba Cistanches 5 parts, Rhizoma Cyperi 5 parts, Fructus Corni 5 parts, Fructus Lycii 2 parts, Os Draconis 3 parts, Herba Apocyni veneti 15 parts, Cortex Moutan 5 parts, Rhizoma Chuanxiong 8 parts, Herba Leonuri 10 parts and Rhizoma Curculiginis 3 parts.
The preparation method of the Chinese medicine preparation for the treatment of chronic heart failure of the present invention, prepare in accordance with the following methods: take raw material of Chinese medicine according to formula and join in container, add water and cover powder immersion 10 ~ 20 minutes, add water again and do not have powder 3 ~ 5 centimetres, decoct with high heat and use slow fire boiling again instead 20 ~ 30 minutes to boiling, get filtrate; And then add water and do not have powder 3 ~ 5 centimetres, decoct with high heat and uses slow fire boiling again instead 15 ~ 20 minutes to boiling, then remove slag and get filtrate, twice filtrate merges.
During use, each 200 ~ 300ml, sooner or later respectively once.
Pharmacology analysis:
Radix Notoginseng: sweet micro-hardship, temperature, nontoxic.Enter liver, stomach, double enter the heart, large intestine.Hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.Root is used as medicine, and containing TANSHINONES, is robustness emmenagogue, has blood stasis dispelling, tissue regeneration promoting, invigorates blood circulation, the effectiveness such as regulating menstruation, is gynecological's key medicine, cures mainly metrorrhagia, menoxenia, blood stasis, stomachache, dysmenorrhoea, amenorrhea, mausoleum pain.Good result is had to treatment coronary heart disease.In addition also control the weak insomnia of nerve, arthralgia, anemia, mastitis, lymphadenitis, arthritis, furuncle pain is swollen, erysipelas, acute, chronic hepatitis, nephropyelitis, traumatic injury, advanced schistosomiasis hepatosplenomegaly, epilepsy.
Radix Rehmanniae Preparata: sweet in the mouth; Warm in nature.Return liver; Kidney channel.Enrich blood moist; Benefit essence fills out marrow; For blood deficiency and yellow complexion; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; To suffer from a deficiency of the kidney dyspnea with rapid and short breath.Modern study, the Dihuang polysaccharide contained by Radix Rehmanniae Preparata has obvious immune antitumor activity, also have significant heart tonifying, diuresis, protect the liver, blood sugar lowering, anti-proliferate, exudation, antiinflammatory, antifungal, the effect such as anti-radiation.
Herba Cistanches: sweet in the mouth; Salty; Warm in nature.Return kidney; Large intestine channel.Kidney-replenishing; Benefiting essence-blood; Intestine moistening road.Main kidney yang deficiency; The sexual impotence of asthenia of essence and blood; Seminal emission; Nebulousurine; The frequent micturition heeltap; Lumbago flaccidity of the lower limbs; Tinnitus order flower; Menstruation is spread out the phase; Infertility; Dryness of the intestine constipation.Herba Cistanches has anti-aging effects to a certain degree.Herba Cistanches can make the activity of mouse red blood cell superoxide dismutase (SOD) obviously strengthen, and mouse cardiac muscle lipofuscin content is obviously reduced.Also the average life of fruit bat, median lethal natural law and maximum life span can be extended.Herba Cistanches water decoction 8g/kg, to mouse stomach, significantly can raise erythrocyte membrane Na
+, K
+-atpase activity, this may be one of mechanism of its benefiting action.
Rhizoma Cyperi: pungent micro-hardship is sweet is flat.Enter liver, tri-jiao channel.To regulate the flow of vital energy resolving depression; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Fructus Corni: sour, puckery, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.
Fructus Lycii: sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Os Draconis: sweet puckery are flat.Enter the heart, liver, kidney, large intestine channel.Tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
Herba Apocyni veneti: sweet-bitter flavor, property is put down, slightly poisonous.Return Liver Channel.Suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria; Hypertension, neurasthenia, nephritis edema.In root of Apocynum venetum L., contained cymarin all can make its shrinkage amplitude increase to the cat heart in vitro and in place, heart rate is slack-off, then arrhythmia, finally heart beating stops at systole, its interaction property is similar to strophanthin with speed, and the central depressants such as pentobarbital sodium can weaken its cardiotonic.With root of Apocynum venetum L. extract, the cat heart in place is tested, also show the effect of cardiotonic glycoside sample.
Cortex Moutan: arduous; Cool; Be slightly cold.GUIXIN; Liver; Kidney; Lung meridian.Heat clearing away; Promoting blood circulation to remove blood stasis.Control the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The pathogenic bacteria later stage brimful of tears, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia.
Rhizoma Chuanxiong: warm in nature, returns liver, gallbladder, heart channel, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, and the pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.
Herba Leonuri: acrid in the mouth is bitter, cool, invigorates blood circulation, silts of dispelling, regulating menstruation, disappears water, treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Herba Leonuri can promote recovering very soon of the regional flow's microcirculation disturbance caused by isoproterenol.Isoproterenol 50 mg/kg, it is downright bad that subcutaneous injection manufactures myocardial ischemia in rats; Respectively at the electrocardiogram selecting the low and T wave height of T wave pressure after 24 hours, within 4 days, select two-phase T ripple electrocardiogram afterwards, treat with motherwort formulation, result is through treating in 1 hour, the electrocardiogram of major part animal all recovers normal, show the early stage ischemia of cardiac muscle (24 hours) even pathological changes, close to ischemic necrosis.
Rhizoma Curculiginis: pungent, heat; Poisonous.Return kidney,liver,spleen warp.Kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness.For sexual impotence cold sperm, muscles and bones flaccidity is soft, the cold numbness of waist knee joint, yang deficiency cold diarrhea.The expansible arteria coronaria of Rhizoma Curculiginis aqueous extract, heart tonifying.Give slow arrhythmia rabbit vein injection 6g/kg, can dramatically increase heart rate, mutant cell digital display is made decline, make the system converting inhibition of enzyme activity of purine about 20%, make cholecystokinin suppress about 80%, make hypothyroidism, the cyclic adenosine monophosphate-C-AMP level reduction person of patients serum is gone up, cyclic guanosine monophosphate level rising person returns and falls, and cyclic adenosine monophosphate-C-AMP/cyclic guanosine monophosphate ratio is tending towards normal.
The invention has the advantages that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable.All medicine phases and there is reinforce functional activities of the heart, the effect such as blood circulation promoting and blood stasis dispelling, diuretic reduce phlegm, treatment chronic heart failure has that determined curative effect, instant effect, cure rate are high, the feature such as have no side effect.
Outcome measure:
1, case selection:
As the medicine for the treatment of chronic heart failure, select chronic heart failure 100 example to carry out clinical observation, wherein man 66 example, women 34 example, age 45-85 year, 62 years old mean age, course of disease 1-10, average 2.4 years.
2, medicine for treatment:
Treatment group patient takes medicine of the present invention, each 200 ~ 300ml, sooner or later respectively once within 7 days, is a course for the treatment of, takes 3-4 the course for the treatment of continuously according to the state of an illness, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, Outcome measure:
According to USA New York cardiology meeting heart failure grade scale (NYHA classification), without heart failure person BNP<80ng/L, cardiac function I grade of person BNP 95 ~ 221ng/L, cardiac function II grade of patient B NP 221 ~ 459ng/L, Ⅲcardiac function patient B NP 459 ~ 1006ng/L, cardiac function IV grade of patient B NP >=1006ng/L.At present, in the world the positive threshold value of patients with heart failure BNP is decided to be 100ng/L, when BNP measured value is below normal value, can thinks and can get rid of heart failure.
Effective: clinical symptoms disappears substantially, test chamber checks that each index of correlation is close to normal level, BNP<100ng/L.
Effective: clinical symptom relief, test chamber checks that each index of correlation makes moderate progress, NYHA classification become better veer promote, sign is improved.
Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4, therapeutic outcome:
Effective 42 examples, effective 51 examples, invalid 7 examples, total effective rate is 93%.
Below enumerate a model case:
Zhang, man, 67 years old, people from Qingdao, in more than 10 years of chronic heart failure, heart rate 95 beats/min, blood pressure 135/72mmHg, cardiac function NYHA III grade, dyspnea, left cardiac ejection fraction 35%, 24h urine volume was about 550ml, hydrosarca, body weight 80.7kg.Before treatment, 24h furosemide consumption 1200mg and spironolactone consumption are 120mg, blood urea nitrogen 21.8mmol/l, serum creatinine 385.6mmol/l, often occur that blood electrolyte is disorderly.When taking first course for the treatment of of invention formulation, heart rate 80 beats/min, cardiac function is improved as II grade, left cardiac ejection fraction 50%, and body weight is 71kg, day urine volume be about 1500ml, blood pressure 130/70mmHg, dyspnea and edema are obviously improved.Follow up a case by regular visits to second course for the treatment of, These parameters is improved further, and patients ' life quality is greatly improved.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
A kind of Chinese medicine preparation for the treatment of chronic heart failure, according to weight parts, formulated by following raw material of Chinese medicine: Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Rehmanniae Preparata 10 parts, Herba Cistanches 3 parts, Rhizoma Cyperi 3 parts, Fructus Corni 3 parts, Fructus Lycii 1 part, Os Draconis 2 parts, Herba Apocyni veneti 10 parts, Cortex Moutan 3 parts, Rhizoma Chuanxiong 5 parts, Herba Leonuri 5 parts and Rhizoma Curculiginis 2 parts.
Embodiment 2:
: a kind of Chinese medicine preparation for the treatment of chronic heart failure, according to weight parts, formulated by following raw material of Chinese medicine: Radix Notoginseng 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Rehmanniae Preparata 15 parts, Herba Cistanches 5 parts, Rhizoma Cyperi 5 parts, Fructus Corni 5 parts, Fructus Lycii 2 parts, Os Draconis 3 parts, Herba Apocyni veneti 15 parts, Cortex Moutan 5 parts, Rhizoma Chuanxiong 8 parts, Herba Leonuri 10 parts and Rhizoma Curculiginis 3 parts.
Embodiment 3:
Formula described in embodiment 1 prepares the Chinese medicine preparation for the treatment of chronic heart failure in accordance with the following methods: take raw material of Chinese medicine according to formula and join in container, add water and cover powder and soak 10 minutes, add water again and do not have powder 3 centimetres, decoct with high heat and use slow fire boiling again instead 20 minutes to boiling, get filtrate; And then add water and do not have powder 3 centimetres, decoct with high heat and uses slow fire boiling again instead 15 minutes to boiling, then remove slag and get filtrate, twice filtrate merges.
Embodiment 4:
Formula described in embodiment 2 prepares the Chinese medicine preparation for the treatment of chronic heart failure in accordance with the following methods: take raw material of Chinese medicine according to formula and join in container, add water and cover powder and soak 20 minutes, add water again and do not have powder 5 centimetres, decoct with high heat and use slow fire boiling again instead 30 minutes to boiling, get filtrate; And then add water and do not have powder 5 centimetres, decoct with high heat and uses slow fire boiling again instead 20 minutes to boiling, then remove slag and get filtrate, twice filtrate merges.
Claims (4)
1. treat the Chinese medicine preparation of chronic heart failure for one kind, it is characterized in that according to weight parts, formulated by following raw material of Chinese medicine: Radix Notoginseng 10 ~ 15 parts, Radix Salviae Miltiorrhizae 15 ~ 20 parts, Radix Rehmanniae Preparata 10 ~ 15 parts, Herba Cistanches 3 ~ 5 parts, Rhizoma Cyperi 3 ~ 5 parts, Fructus Corni 3 ~ 5 parts, Fructus Lycii 1 ~ 2 part, Os Draconis 2 ~ 3 parts, Herba Apocyni veneti 10 ~ 15 parts, Cortex Moutan 3 ~ 5 parts, Rhizoma Chuanxiong 5 ~ 8 parts, Herba Leonuri 5 ~ 10 parts and Rhizoma Curculiginis 2 ~ 3 parts.
2. the Chinese medicine preparation for the treatment of chronic heart failure according to claim 1, it is characterized in that according to weight parts, formulated by following raw material of Chinese medicine: Radix Notoginseng 10 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Rehmanniae Preparata 10 parts, Herba Cistanches 3 parts, Rhizoma Cyperi 3 parts, Fructus Corni 3 parts, Fructus Lycii 1 part, Os Draconis 2 parts, Herba Apocyni veneti 10 parts, Cortex Moutan 3 parts, Rhizoma Chuanxiong 5 parts, Herba Leonuri 5 parts and Rhizoma Curculiginis 2 parts.
3. the Chinese medicine preparation for the treatment of chronic heart failure according to claim 1, it is characterized in that according to weight parts, formulated by following raw material of Chinese medicine: Radix Notoginseng 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Rehmanniae Preparata 15 parts, Herba Cistanches 5 parts, Rhizoma Cyperi 5 parts, Fructus Corni 5 parts, Fructus Lycii 2 parts, Os Draconis 3 parts, Herba Apocyni veneti 15 parts, Cortex Moutan 5 parts, Rhizoma Chuanxiong 8 parts, Herba Leonuri 10 parts and Rhizoma Curculiginis 3 parts.
4. the preparation method of the Chinese medicine preparation of a treatment chronic heart failure according to claim 1, it is characterized in that preparing in accordance with the following methods: take raw material of Chinese medicine according to formula and join in container, add water and cover powder immersion 10 ~ 20 minutes, add water again and do not have powder 3 ~ 5 centimetres, decoct with high heat and use slow fire boiling again instead 20 ~ 30 minutes to boiling, get filtrate; And then add water and do not have powder 3 ~ 5 centimetres, decoct with high heat and uses slow fire boiling again instead 15 ~ 20 minutes to boiling, then remove slag and get filtrate, twice filtrate merges.
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| CN105435131A (en) * | 2016-01-14 | 2016-03-30 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for treating chronic heart failure and preparation method thereof |
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| CN101524480A (en) * | 2008-03-07 | 2009-09-09 | 天科仁祥技术（北京）有限责任公司 | Chinese medicinal composition for reducing blood pressure and preparation method thereof |
| CN105726854A (en) * | 2014-12-11 | 2016-07-06 | 青岛市黄岛区中医医院 | Traditional Chinese medicine preparation for treating chronic heart failure and preparation method thereof |
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| CN101524480A (en) * | 2008-03-07 | 2009-09-09 | 天科仁祥技术（北京）有限责任公司 | Chinese medicinal composition for reducing blood pressure and preparation method thereof |
| CN105726854A (en) * | 2014-12-11 | 2016-07-06 | 青岛市黄岛区中医医院 | Traditional Chinese medicine preparation for treating chronic heart failure and preparation method thereof |
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|---|---|---|---|---|
| CN105435131A (en) * | 2016-01-14 | 2016-03-30 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for treating chronic heart failure and preparation method thereof |
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Application publication date: 20150429 |