CN105726642B - Honeysuckle flower cold granules and preparation method thereof - Google Patents
Honeysuckle flower cold granules and preparation method thereof Download PDFInfo
- Publication number
- CN105726642B CN105726642B CN201610186516.9A CN201610186516A CN105726642B CN 105726642 B CN105726642 B CN 105726642B CN 201610186516 A CN201610186516 A CN 201610186516A CN 105726642 B CN105726642 B CN 105726642B
- Authority
- CN
- China
- Prior art keywords
- parts
- honeysuckle flower
- honeysuckle
- granules
- cold granules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses honeysuckle flower cold granules which are prepared from the following raw materials: 3000-5000 parts of honeysuckle, 3000-5000 parts of fructus forsythiae, 3000-5000 parts of divaricate saposhnikovia root, 3000-5000 parts of platycodon grandiflorum, 1500-2000 parts of liquorice, 0.6-30 parts of dextrin, 0.2-10 parts of maltodextrin and 0.3-10 parts of steviosin. The auxiliary material steviosin is used as a flavoring agent to cover the bitter taste of the flavoring agent, the prepared product has the best taste, and dextrin and maltodextrin are selected for granulation, so that the flavoring agent is not easy to loosen and has moderate hardness. The invention also provides a preparation method of the honeysuckle particles, and the raw materials are cooked in a dynamic stirring manner, so that the extraction and concentration are completed in one step, the raw materials and the working time are greatly saved, and the effective concentration of the extracting solution is improved. The preparation method is simple, short in production period, free of any special equipment, low in cost and suitable for industrial production.
Description
The application is a divisional application of the honeysuckle flower cold granules and the preparation method thereof, the application date of the original application is 4 months and 14 days in 2014, and the application number of the original application is 201410149268.1.
Technical Field
The invention relates to the field of pharmaceutical preparations, in particular to honeysuckle cold granules and a preparation method thereof.
Background
The honeysuckle flower cold granules are collected in the second volume of the traditional Chinese medicine preparations of the ministry of health, namely the drug Standard, and are traditional Chinese medicine preparations prepared from 6 traditional Chinese medicines such as honeysuckle flower, divaricate saposhnikovia root, weeping forsythia and the like, have the effects of clearing heat, relieving exterior syndrome and relieving sore throat, and can be used for treating cold fever, headache and sore throat and effectively treating wind-heat type cold.
One of the main ingredients of the Yinhua Ganmao granule is honeysuckle, also called Yinhua and honeysuckle, which is the flower bud of Lonicera japonica of the semi-evergreen entwining woody vine plant of Caprifoliaceae. In clinic, honeysuckle is a commonly used heat-clearing and detoxifying traditional Chinese medicine, has cold and sweet taste, can enter lung channels, stomach channels and large intestine channels, is mainly used for treating fever, slight aversion to wind-cold, sore throat and other symptoms caused by exogenous wind-heat or warm diseases, and can also be used for treating sore and carbuncle pyogenic infections, dysentery and hematochezia caused by heat toxin. In the present herbal sense: honeysuckle flower, flos Lonicerae, good at resolving toxin, is the key herb for treating toxicity of abscess, deep rooted carbuncle, swelling and toxin, sore, tinea, red bayberry and rheumatism.
The Chinese patent application with the application number of 200710168363.6 discloses a sugar-free honeysuckle flower cold particle and a production process thereof, wherein water is adopted for decocting twice, and decoction is combined after 3 hours and 2 hours respectively. In addition, in the long-time decoction process, energy is consumed, the environment is polluted, time and labor are wasted, and the modern production of the traditional Chinese medicine is not facilitated.
If a novel honeysuckle flower cold particle formula and a preparation method thereof can be developed to realize low cost and high quality, the honeysuckle flower cold particle formula has good market prospect.
Disclosure of Invention
The invention aims to provide a preparation method of a traditional Chinese medicine compound preparation honeysuckle flower cold granules with high extraction rate of effective components and easy absorption aiming at the defects.
The invention also provides the honeysuckle flower cold particles prepared by the preparation method, and the honeysuckle flower cold particles have good taste, are particularly suitable for children and dysphagia people, and have good medication compliance.
A preparation method of honeysuckle flower cold granules comprises the following steps:
(1) dynamically extracting flos Lonicerae and Glycyrrhrizae radix with 9-11 times of water at 90-98 deg.C, controlling rotation speed at 50-60 r/min, and obtaining first extractive solution after 2-3 hr; then, dynamically extracting the divaricate saposhnikovia root, the platycodon root and the weeping forsythia with water in an amount which is 8-10 times of the weight of the medicinal materials (namely the divaricate saposhnikovia root, the platycodon root and the weeping forsythia), controlling the rotating speed to be 40-50 r/min, and obtaining a second extracting solution after 2-3 hours; mixing the first extract and the second extract, and filtering, ultracentrifuging and concentrating at low pressure to obtain a first concentrated solution;
(2) adding ethanol with the same volume into the first concentrated solution obtained in the step (1), stirring uniformly, standing for 10-12 hours, filtering, recovering ethanol from the filtrate, and concentrating to obtain a second concentrated solution with the relative density of 1.0-1.2; spray drying the obtained second concentrated solution to obtain dry extract powder;
(3) and (3) adding auxiliary materials into the dry paste powder obtained in the step (2) and pouring into a mixer to mix for 20-30 minutes, granulating by a dry method, and sieving granules after granulation by a vibrating sieve to obtain the honeysuckle flower cold granules.
The relative density in the present invention means a density at 60 ℃ relative to water.
According to the invention, the raw materials are cooked in a dynamic stirring manner, and the rotating speed of dynamic stirring is strictly controlled, so that the raw materials and the working time are greatly saved, and the effective concentration of the extracting solution is improved; meanwhile, according to the different properties of each component in the medicinal materials (the inventor finds that the effective components of the divaricate saposhnikovia root, the platycodon grandiflorum and the fructus forsythiae are easier to extract and the impurities are easier to extract relatively compared with the honeysuckle and the liquorice through a plurality of tests), the medicinal materials are separately extracted, different temperatures, water amounts and rotating speeds are controlled, the precipitation of the impurities is reduced while the effective components are fully extracted, therefore, the content of the effective components of the honeysuckle cold particles obtained by the preparation method is high, and the identification item meets the requirement.
Preferably, the auxiliary materials consist of dextrin, maltodextrin and stevioside. The steviosin is used as a flavoring agent and can improve the mouthfeel of the product; dextrin and maltodextrin are used as diluents simultaneously to improve the solubility of the product.
Preferably, the medicinal materials and the auxiliary materials are as follows in parts by weight:
as a further preference, the ratio of dextrin to maltodextrin is 3:1, and the dextrin and the maltodextrin in the ratio can moderate the hardness of the product, facilitate granulation and have better dissolubility.
Most preferably, the medicinal materials and the auxiliary materials are as follows in parts by weight:
in the most preferred compositions, the dextrin, maltodextrin and stevia are used in small amounts, but already to improve the mouthfeel and melting properties of the product and to maximize the content of active ingredients in the product.
In the step (1), during dynamic extraction, 3-4 times of hot water at about 80 ℃ is added into an extraction tank in advance, then the medicinal materials are added, and finally the rest of hot water is added to perform extraction at 40-60 r/min, so that the extraction efficiency can be further improved.
In the step (1), preferably, the vacuum degree of low-pressure concentration is-0.07 to-0.08 MPa, the temperature is 65 to 75 ℃, and the relative density of the obtained first concentrated liquid phase is 1.20 to 1.25.
In the step (2), some water-soluble impurities can be removed by adding ethanol, so that the impurity content in the product is reduced.
Preferably, the air inlet temperature of the spray drying method is controlled to be 180-190 ℃, the air outlet temperature is controlled to be 85-95 ℃, and the pressure in the tower is kept at-5 mmH2O。
In the step (3), preferably, the pressure of the roller for dry granulation is 60Pa to 80Pa, the rotation speed of the roller is 10 rpm to 16 rpm, and the conveying speed of the mixture is 45 rpm to 65 rpm.
The invention also provides honeysuckle flower cold granules prepared by the preparation method. The flos Lonicerae granule for treating common cold has good taste and easy absorption.
The medicinal materials adopted by the invention are specifically described as follows:
honeysuckle is a perennial semi-evergreen wound woody liana of Caprifoliaceae, and has the effects of clearing away heat and toxic materials and dispelling wind and heat. Can be used for treating swelling and pain, furuncle, sore throat, erysipelas, toxic heat, dysentery, wind-heat type common cold, epidemic febrile disease, and fever.
Fructus forsythiae is fruit of Forsythia suspensa of Oleaceae, and has effects of clearing away heat and toxic materials, relieving swelling, dispelling heat, and dispelling wind and heat. Can be used for treating superficial infection, scrofula, mastalgia, erysipelas, wind-heat type common cold, early epidemic febrile disease, fever, polydipsia, coma, macula, and stranguria caused by heat.
Radix Saposhnikoviae is dried root of radix Saposhnikoviae belonging to Umbelliferae, and has effects in expelling pathogenic wind, relieving fever, eliminating dampness, relieving pain, and relieving spasm. Can be used for treating common cold, headache, rheumatalgia, rubella, pruritus, and tetanus.
Radix Platycodi is a plant of Campanulaceae, has effects of dispersing lung qi, eliminating phlegm, relieving sore throat, and expelling pus, and can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung pain, and pus discharge.
The licorice is licorice of Leguminosae, and has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, spasm and pain of wrist, abdomen and limbs, carbuncle, swelling, sore, and toxic material, and relieving drug toxicity and pungency.
The invention has the advantages that:
the honeysuckle flower cold treating granule has bitter taste, and the auxiliary material steviosin is used as a flavoring agent to cover the bitter taste of the honeysuckle flower cold treating granule, so that the prepared product has the best taste, and dextrin and maltodextrin are selected for granulation, so that the dissolubility is better. And the raw materials are cooked in a dynamic stirring manner, so that the extraction and concentration are completed in one step, the raw materials and the working time are greatly saved, and the effective concentration of the extracting solution is improved. The preparation method is simple, short in production period, free of any special equipment, low in cost and suitable for industrial production.
Detailed Description
Example 1
Prescription: measured in 1000 bags (Specification: 3 g/bag)
The method comprises the following operation steps:
(1) adding hot water of which the amount is about 3 times that of the medicinal materials and the temperature is about 80 ℃ into an extraction tank in advance, adding 3520g of honeysuckle and 1750g of liquorice into the extraction tank, supplementing the hot water to 10 times that of the medicinal materials, heating the water to 95 ℃, and dynamically extracting for 2 hours by stirring at 50 r/min to obtain a first extracting solution; then, 3520g of forsythia suspense, 3520g of divaricate saposhnikovia root and 3520g of platycodon grandiflorum are put into an extraction tank, water with the weight 9 times of the weight of the medicinal materials is stirred and dynamically extracted for 2 hours at the temperature of 85 ℃ at 45 r/min to obtain a second extracting solution, the first extracting solution and the second extracting solution are mixed and filtered, filtrate is put into an ultracentrifuge for ultracentrifugation, and the filtrate is concentrated at low pressure (the vacuum degree is-0.075 MPa, the temperature is 70 ℃, and the relative density of a concentrated liquid phase is 1.20) for later use;
(2) adding equal volume of ethanol into the concentrated solution, stirring, standing for 12 hr, filtering, recovering ethanol from the filtrate, and concentrating to relative density of about 1.10(60 deg.C). The instantaneous spray drying is adopted, the inlet air temperature is controlled at 185 ℃, the outlet air temperature is controlled at 90 ℃, and the pressure in the tower is kept at-5 mmH2O, obtaining 3556g of dry paste powder;
(3) 6g of dextrin, 2g of maltodextrin and 4g of steviosin are added into the dry paste powder obtained by spray drying and poured into a mixer for mixing for 20 minutes. Dry granulation was carried out at a roll pressure of 75Pa, a rotation speed of the rolls of 12 revolutions per minute and a conveying speed of the mixture of 55 revolutions per minute. And (4) sieving the granulated granules by using a vibrating screen to obtain the honeysuckle flower cold granules.
Example 2
Prescription: measured in 1000 bags (Specification: 3 g/bag)
The method comprises the following operation steps:
(1) adding hot water 3 times the amount of the medicinal materials and about 80 ℃ into an extraction tank in advance, adding 3520g of honeysuckle and 1750g of liquorice into the extraction tank, supplementing the hot water to 10 times the amount of the medicinal materials, heating the water to 98 ℃, and dynamically extracting for 2 hours under the stirring at 55 revolutions per minute to obtain a first extracting solution. Then 3520g of forsythia, 3520g of divaricate saposhnikovia root and 3520g of platycodon grandiflorum are put into an extraction tank, and are stirred and dynamically extracted for 2 hours at the temperature of 80 ℃ by water with the weight of 8 times of the weight of the medicinal materials at 50 r/min, so that a second extracting solution is obtained. Mixing the first extractive solution and the second extractive solution, filtering, placing the filtrate in an ultracentrifuge, ultracentrifuging, and concentrating the filtrate at low pressure (vacuum degree-0.08 MPa, temperature 65 deg.C, and relative density of concentrated solution of 1.20);
(2) adding equal volume of ethanol into the concentrated solution, stirring, standing for 12 hr, filtering, recovering ethanol from the filtrate, and concentrating to relative density of about 1.10(60 deg.C). Adopting instantaneous spray drying, controlling inlet air temperature at 180 deg.C, outlet air temperature at 93 deg.C, and tower internal pressure at-5 mmH2O, obtaining 3528g of dry paste powder;
(3) adding dextrin 9g, maltodextrin 3g and steviosin 3g into the obtained dry extract powder by spray drying, and mixing in a mixer for 20 minutes. Dry granulation was carried out at a roll pressure of 70Pa, a rotation speed of the rolls of 12 revolutions per minute and a conveying speed of the mixture of 55 revolutions per minute. And (4) sieving the granulated granules by using a vibrating screen to obtain the honeysuckle flower cold granules.
Example 3
Prescription: measured in 1000 bags (Specification: 3 g/bag)
The method comprises the following operation steps:
(1) adding hot water 3 times the amount of the medicinal materials and about 80 ℃ into an extraction tank in advance, adding 3520g of honeysuckle and 1750g of liquorice into the extraction tank, supplementing the hot water to 11 times the amount of the medicinal materials, heating the water to 93 ℃, and dynamically extracting for 2 hours under the stirring at 60 r/min to obtain a first extracting solution. Then 3520g of forsythia, 3520g of divaricate saposhnikovia root and 3520g of platycodon grandiflorum are put into an extraction tank, and are stirred and dynamically extracted for 2 hours at 80 ℃ by water with the weight of 8 times of the weight of the medicinal materials at 40 r/min under stirring to obtain a second extracting solution. Mixing the first extractive solution and the second extractive solution, filtering, placing the filtrate in an ultracentrifuge, ultracentrifuging, and concentrating the filtrate at low pressure (vacuum degree-0.07 MPa, temperature 75 deg.C, and relative density of concentrated solution 1.20);
(2) adding equal volume of ethanol into the concentrated solution, stirring, standing for 12 hr, filtering, and recovering ethanol from the filtrateAnd concentrated to a relative density of about 1.10(60 ℃). Adopting instantaneous spray drying, controlling inlet air temperature at 190 deg.C, outlet air temperature at 80 deg.C, and tower pressure at-5 mmH2O, obtaining 3563g of dry paste powder;
(3) the dry paste powder obtained by spray drying is added with 12g of dextrin, 4g of maltodextrin and 5g of steviosin and poured into a mixer for mixing for 20 minutes. Dry granulation was carried out at a roll pressure of 80Pa, a rotation speed of the rolls of 12 revolutions per minute and a conveying speed of the mixture of 55 revolutions per minute. And (4) sieving the granulated granules by using a vibrating screen to obtain the honeysuckle flower cold granules.
Comparative example 1
Prescription: measured in 1000 bags (Specification: 3 g/bag)
The method comprises the following operation steps:
the procedure is as in example 1 except that no dextrin is added.
Comparative example 2
Prescription: measured in 1000 bags (Specification: 3 g/bag)
The method comprises the following operation steps:
the procedure of example 1 was followed except that maltodextrin was added.
Comparative example 3
Prescription: measured in 1000 bags (Specification: 3 g/bag)
The method comprises the following operation steps:
(1) weighing 3520g of honeysuckle, 3520g of forsythia, 3520g of divaricate saposhnikovia root, 3520g of platycodon root and 1750g of liquorice, adding water, decocting twice for 3 hours for the first time, wherein the amount of the water for the first time is 10 times that of the medicinal materials, and for 2 hours for the second time, the amount of the water for the second time is 8 times that of the medicinal materials, merging decoction, and filtering. Placing the filtrate in an ultracentrifuge, ultracentrifuging, and concentrating the filtrate under low pressure (vacuum degree of-0.08 MPa, temperature of 65 deg.C, relative density of concentrated solution of 1.20);
(2) adding equal volume of ethanol into the concentrated solution, stirring, standing for 12 hr, filtering, recovering ethanol from the filtrate, and concentrating to relative density of about 1.10(60 deg.C). Adopting instantaneous spray drying, controlling inlet air temperature at 180 deg.C, outlet air temperature at 93 deg.C, and tower internal pressure at-5 mmH2O, obtaining 2311g of dry paste powder;
(3) the dry paste powder obtained by spray drying is added with 0.6g of dextrin, 0.2g of maltodextrin and 0.4g of steviosin and poured into a mixer to be mixed for 20 minutes. Dry granulation was carried out at a roll pressure of 75Pa, a rotation speed of the rolls of 12 revolutions per minute and a conveying speed of the mixture of 55 revolutions per minute. And (4) sieving the granulated granules by using a vibrating screen to obtain the honeysuckle flower cold granules.
Comparative example 4
Prescription: measured in 1000 bags (Specification: 3 g/bag)
The method comprises the following operation steps:
(1) weighing 3520g of honeysuckle, 3520g of forsythia, 3520g of divaricate saposhnikovia root, 3520g of platycodon root and 1750g of liquorice, adding water, decocting twice for 3 hours for the first time, wherein the amount of the water for the first time is 10 times that of the medicinal materials, and for 2 hours for the second time, the amount of the water for the first time is 8 times that of the medicinal materials, merging decoction, and filtering. Placing the filtrate in an ultracentrifuge, ultracentrifuging, and concentrating the filtrate under low pressure (vacuum degree of-0.08 MPa, temperature of 65 deg.C, relative density of concentrated solution of 1.20);
(2) adding equal volume of ethanol into the concentrated solution, stirring, standing for 12 hr, filtering, recovering ethanol from the filtrate, and concentrating to relative density of about 1.10(60 deg.C). Adopting instantaneous spray drying, controlling inlet air temperature at 180 deg.C, outlet air temperature at 93 deg.C, and tower internal pressure at-5 mmH2O, obtaining 2394g of dry paste powder;
(3) the resulting dry extract powder was spray-dried, 18g of starch was added, and the mixture was poured into a mixer and mixed for 30 minutes. Dry granulation was carried out at a roll pressure of 75Pa, a rotation speed of the rolls of 12 revolutions per minute and a conveying speed of the mixture of 55 revolutions per minute. And (4) sieving the granulated granules by using a vibrating screen to obtain the honeysuckle flower cold granules.
Thin-layer identification of honeysuckle: taking 5g of compound honeysuckle flower cold granules, adding 5mL of methanol, carrying out ultrasonic treatment for 20min, and filtering to obtain filtrate as a test solution. And preparing a negative control solution without honeysuckle flower by the same method. And adding methanol into chlorogenic acid reference substance to prepare lml solution containing lmg as reference substance solution. According to a test of thin-layer chromatography (appendix VIB of the first part of the Chinese pharmacopoeia 2010 edition) 12, 10ul of each of the three solutions is absorbed, the three solutions are respectively spotted on the same silica gel G thin-layer plate which takes sodium carboxymethylcellulose as a binder, an upper layer solution of acetic acid butyl acetate-formic acid-water (7:25, 25) is taken as a developing agent, and the solution is developed, taken out, dried and inspected under an ultraviolet lamp (365 nm). The chromatogram of the test solution shows fluorescence spots with the same color at the corresponding positions of the chromatogram of the chlorogenic acid control solution.
The quality of the honeysuckle flower cold particles prepared in the examples 1 to 3 and the honeysuckle flower cold particles prepared in the comparative examples 1 to 4 is tested according to a method of appendix I X of the second part of Chinese pharmacopoeia of 2005 edition, and the test results of the items are as follows:
various inspection data of honeysuckle flower cold granules
As can be seen from the inspection data in Table 1, the mouth feel, the solubility, the loss on drying and the stability of the examples 1, 2 and 3 are superior to those of the comparative examples 1, 2, 3 and 4, the production period of the invention is short, the quality is controllable, the cost is saved, the operation is simple, the industrial production requirement is met, and the preparation method is superior to the existing preparation method.
Claims (4)
1. The honeysuckle flower cold granules are characterized by being prepared from the following medicinal materials and auxiliary materials in parts by weight:
the preparation method of the honeysuckle flower cold granules comprises the following steps:
(1) dynamically extracting flos Lonicerae and Glycyrrhrizae radix with 9-11 times of water at 90-98 deg.C, controlling rotation speed at 50-60 r/min, and obtaining first extractive solution after 2-3 hr; then, at the temperature of 80-90 ℃, the divaricate saposhnikovia root, the platycodon grandiflorum and the fructus forsythiae are dynamically extracted by water with the weight of 8-10 times of that of the medicinal materials, the rotating speed is controlled to be 40-50 r/min, and a second extracting solution is obtained after 2-3 hours; mixing the first extract and the second extract, and filtering, ultracentrifuging and concentrating at low pressure to obtain a first concentrated solution;
(2) adding ethanol with the same volume into the first concentrated solution obtained in the step (1), stirring uniformly, standing for 10-12 hours, filtering, recovering ethanol from the filtrate, and concentrating to obtain a second concentrated solution with the relative density of 1.0-1.2; spray drying the obtained second concentrated solution to obtain dry extract powder;
(3) and (3) adding auxiliary materials into the dry paste powder obtained in the step (2) and pouring into a mixer to mix for 20-30 minutes, granulating by a dry method, and sieving granules after granulation by a vibrating sieve to obtain the honeysuckle flower cold granules.
2. The honeysuckle flower cold granules according to claim 1, wherein in the step (1), the vacuum degree of low-pressure concentration is-0.07 to-0.08 MPa, the temperature is 65 to 75 ℃, and the relative density of the obtained first concentrated liquid is 1.20 to 1.25g/cm3。
3. The honeysuckle flower cold granules as claimed in claim 1, wherein in the step (2), the air inlet temperature of the spray drying method is controlled to be 180-190 ℃, the air outlet temperature is controlled to be 85-95 ℃, and the pressure in the tower is kept at-5 mmH2O。
4. The honeysuckle influenza granulation of claim 1, wherein in step (3), the pressure of the rollers for dry granulation is 60Pa to 80Pa, the rotation speed of the rollers is 10 rpm to 16 rpm, and the conveying speed of the mixture is 45 rpm to 65 rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610186516.9A CN105726642B (en) | 2014-04-14 | 2014-04-14 | Honeysuckle flower cold granules and preparation method thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410149268.1A CN103919860B (en) | 2014-04-14 | 2014-04-14 | Honeysuckle flower common cold granule and preparation method thereof |
| CN201610186516.9A CN105726642B (en) | 2014-04-14 | 2014-04-14 | Honeysuckle flower cold granules and preparation method thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410149268.1A Division CN103919860B (en) | 2014-04-14 | 2014-04-14 | Honeysuckle flower common cold granule and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105726642A CN105726642A (en) | 2016-07-06 |
| CN105726642B true CN105726642B (en) | 2020-01-14 |
Family
ID=56252230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610186516.9A Active CN105726642B (en) | 2014-04-14 | 2014-04-14 | Honeysuckle flower cold granules and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105726642B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114028455A (en) * | 2021-12-20 | 2022-02-11 | 黑龙江中医药大学附属第二医院 | Preparation process of honeysuckle detoxification mixture capable of improving immunity |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899551A (en) * | 2006-07-13 | 2007-01-24 | 广东化州中药厂制药有限公司 | Sugar-free type red tangerine peel granular agent for treating productive cough |
| CN101433594A (en) * | 2007-11-15 | 2009-05-20 | 湖北广仁药业有限公司 | Sugar-free honeysuckle flower common cold granule |
-
2014
- 2014-04-14 CN CN201610186516.9A patent/CN105726642B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899551A (en) * | 2006-07-13 | 2007-01-24 | 广东化州中药厂制药有限公司 | Sugar-free type red tangerine peel granular agent for treating productive cough |
| CN101433594A (en) * | 2007-11-15 | 2009-05-20 | 湖北广仁药业有限公司 | Sugar-free honeysuckle flower common cold granule |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105726642A (en) | 2016-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103071006B (en) | Preparation method and quality inspection method of traditional Chinese medicine for treating kidney failure | |
| CN103316096A (en) | General flavone extract of seeds of nigella damascena l., nigella sativa l. or nigella glandulifera freyn et sint., and preparation method and use thereof | |
| CN103919860B (en) | Honeysuckle flower common cold granule and preparation method thereof | |
| CN111494507B (en) | Preparation method of internal heat clearing tablets | |
| CN101904948A (en) | Traditional Chinese medicine preparation of new Zhongsheng pill and preparation method thereof | |
| CN1785233A (en) | Method for preparing glycyrrhiza dispensing granules | |
| CN106235341A (en) | A kind of bamboo shoot edible fiber extracting method and the granule for the treatment of constipation | |
| CN103784923A (en) | Bupleurum tenue granules and preparation method thereof | |
| CN105726642B (en) | Honeysuckle flower cold granules and preparation method thereof | |
| CN106389776B (en) | A kind of trollius chinensis granular agent and preparation method thereof | |
| CN104127471A (en) | Preparation method and quality control method for honeysuckle flower formula granule | |
| CN104524273A (en) | Preparation method of Yinqiao preparation | |
| CN102488061B (en) | Tea extract sugar and its production method | |
| CN108143833A (en) | A kind of preparation method of licorice piece | |
| CN103860880A (en) | Loquat leaf extract and preparing method thereof | |
| CN113082071A (en) | Chinese patent medicine preparation for pneumonia and preparation method thereof | |
| CN106236993A (en) | A kind of concocting method of Rhizoma Pinelliae | |
| CN104672205A (en) | Compound used as food sweetener | |
| CN111298009A (en) | Traditional Chinese medicine pills for treating infantile pneumonia and cough and preparation method thereof | |
| CN105168188B (en) | The preparation method and its product of dendrobium candidum oral quick-dissolving film preparation | |
| CN107890519A (en) | A kind of dendrobium candidum soft capsule and preparation method thereof | |
| CN107260915A (en) | A kind of Chinese medicinal granule and preparation method thereof for the excessive internal heat that is used to having a toothache | |
| CN106234907A (en) | A kind of solid beverage for moistening and cleaning throat profit throat and preparation method thereof | |
| CN103623203A (en) | Method for preparing cough-suppressing oral preparation | |
| CN103705581B (en) | Compound Huodan dispersible tablet and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |