CN105726642A - Honeysuckle Ganmao granules and preparation method thereof - Google Patents
Honeysuckle Ganmao granules and preparation method thereof Download PDFInfo
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Abstract
The invention discloses honeysuckle Ganmao granules, prepared from the following raw materials: 3000-5000 parts of honeysuckle, 3000-5000 parts of fructus forsythiae, 3000-5000 parts of radix sileris, 3000-5000 parts of platycodon grandiflorum, 1500-2000 parts of liquorice, 0.6-30 parts of dextrin, 0.2-10 parts of maltodextrin and 0.3-10 parts of steviosin. The honeysuckle Ganmao granules take the adjuvant steviosin as a corrigent to cover the bitterness of the medicine, the prepared product has best mouthfeel, and simultaneously, by adopting the dextrin and maltodextrin for granulating, the granules are not liable to loose and are neither too hard nor too soft. The invention also provides a preparation method of the honeysuckle granules, the raw materials are decocted by dynamically stirring, so that extraction and concentration are finished in one step and the raw materials and working time are greatly saved, and the effective concentration of the extracting solution is improved. The preparation method has the advantages of simplicity, short production cycle, no need of any special equipment, low cost and suitability for commercial process.
Description
The application is the divisional application of " honeysuckle flower common cold granule and preparation method thereof ", and the applying date of original application is on April 14th, 2014, and the application number of original application is 201410149268.1.
Technical field
The present invention relates to field of pharmaceutical preparations, be specifically related to a kind of honeysuckle flower common cold granule and preparation method thereof.
Background technology
Honeysuckle flower common cold granule is concealed in Ministry of Public Health " drug standard " Chinese medicine and becomes second, preparation, the Chinese medicine preparation being made up of 6 taste medical materials such as Flos Lonicerae, Radix Saposhnikoviae, Fructus Forsythiaes, there is heat clearing away, induce sweat, sore-throat relieving, can be used for cold, fever, headache, laryngopharynx swelling and pain, effectively treat anemopyretic cold.
One of honeysuckle flower common cold granule main component is Flos Lonicerae, has another name called Flos Lonicerae, Flos Lonicerae, is the alabastrum of Caprifoliaceae half evergreen prehensile bejuco Radix Ophiopogonis.Clinically, Flos Lonicerae is a kind of conventional antipyretic and antidotal type Chinese medicine, its cold in nature, sweet in the mouth, lung meridian, stomach warp and large intestine channel can be entered, it is used for the diseases such as heating, cold, the laryngopharynx swelling and pain of micro evil wind that treatment causes by affection due to external wind and heat or epidemic febrile disease, it is also possible to the disease such as have blood in stool in treatment sore and toxic and the dysentery that caused by pyretic toxicity.Book on Chinese herbal medicine justice is pointed out: " Flos Lonicerae is good at removing toxic substances, therefore controls swollen ulcer drug, skin ulcer tinea Fructus Myricae rubrae, all poison of rheumatism, is really key medicine ".
Application number is a kind of sugar-free honeysuckle flower common cold granule and production technology thereof disclosed in the Chinese invention patent application of 200710168363.6, adopt boiling secondary, respectively collecting decoction after 3 hours and 2 hours, the method is than relatively time-consuming and manpower and materials, and through inspection, the decocting liquid concentration extracted is low.It addition, in long decoction process, not only consuming energy but also contaminated environment, waste time and energy, be unfavorable for that the reality modernization of Chinese medicine produces.
If able to develop a kind of new honeysuckle flower common cold granule formula and preparation method thereof, to realize low-cost high-quality, will have good market prospect.
Summary of the invention
It is an object of the invention to for defect described above, it is provided that a kind of effective component extraction rate is high, the preparation method of the compound Chinese medicinal preparation honeysuckle flower common cold granule easily absorbed.
Present invention also offers a kind of honeysuckle flower common cold granule prepared by this preparation method, this honeysuckle flower common cold granule has good mouthfeel, is particularly suitable for the crowd of child and dysphagia, and medication compliance is good.
The preparation method of a kind of honeysuckle flower common cold granule, comprises the steps:
(1) at 90-98 DEG C of temperature, with the water of medical material weight (referring to Flos Lonicerae and Radix Glycyrrhizae) 9-11 times amount, Flos Lonicerae, Radix Glycyrrhizae are carried out dynamic extraction, control rotating speed be 50～60 turns/min, 2-3 hour after obtain the first extracting solution；Again at 80-90 DEG C of temperature, with the water of medical material weight (referring to Radix Saposhnikoviae, Radix Platycodonis and Fructus Forsythiae) 8-10 times amount, Radix Saposhnikoviae, Radix Platycodonis and Fructus Forsythiae carried out dynamic extraction, control rotating speed be 40～50 turns/min, 2-3 hour after obtain the second extracting solution；After described first extracting solution and the second extracting solution being merged, after filtration, ultracentrifugation and low pressure concentration, obtain the first concentrated solution；
(2) adding isopyknic ethanol in the first concentrated solution obtained to step (1), stir evenly, stand 10-12 hour, filter, filtrate recycling ethanol is also concentrated into the second concentrated solution that relative density is 1.0-1.2；The second concentrated solution obtained obtains dried cream powder through spray drying method；
(3) step (2) gained dried cream powder adding adjuvant and pours mixing 20-30 minute in mixer into, with dry granulation, the granule after granulation crosses shaking screen, obtains described honeysuckle flower common cold granule.
Relative density in the present invention, refers to the density relative to water at 60 DEG C.
The present invention by by raw material with dynamic agitation mode steaming and decocting, and strictly control the rotating speed of dynamic agitation, be greatly saved raw material and working time, improve the valid density of extracting solution；Simultaneously, according to the different in kind of each component in medical material, (the present inventor finds to compare with Radix Glycyrrhizae with Flos Lonicerae through test of many times, the effective ingredient of Radix Saposhnikoviae, Radix Platycodonis and Fructus Forsythiae is easier to extract, but impurity is also more easy to and extracts comparatively speaking), medical material is separately extracted, control different temperature, the water yield and rotating speed, while ensureing that effective ingredient fully extracts, reduce the precipitation of impurity, therefore, adopt the honeysuckle flower common cold granule active constituent content that this preparation method obtains high, differentiate that item meets the requirements.
As preferably, described adjuvant is made up of dextrin, maltodextrin and steviosin.Wherein, described steviosin is used as correctives, it is possible to improve the mouthfeel of product；Dextrin and maltodextrin are simultaneously as diluent, for improving the melting of product.
As preferably, described medical material and the weight portion of adjuvant are as follows:
As further preferably, described dextrin and the ratio of maltodextrin are 3:1, and the dextrin of this ratio and maltodextrin can make the neither too hard, nor too soft of product, it is simple to granulate, and melting is better.
As most preferably, described medical material and the weight portion of adjuvant are as follows:
In this most preferred component, the consumption of dextrin, maltodextrin and steviosin is little, but has been able to improve the mouthfeel of product and dissolve performance, and can improve the content of active component in product to greatest extent.
In step (1), during dynamic extraction, in extraction pot, add the hot water of medical material 3～4 times amount about 80 DEG C in advance, be subsequently adding medical material, finally add remaining hot water, carry out 40～60 turns/min and extract, at this point it is possible to improve the efficiency extracted further.
In step (1), as preferably, the vacuum of low pressure concentration is-0.07～-0.08MPa, and temperature is 65～75 DEG C, and the first concentrated solution relative density obtained is 1.20～1.25.
In step (2), some water miscible impurity can be removed by adding ethanol, reduce the impurity content in product.
As preferably, the inlet temperature of spray drying method controls at 180～190 DEG C, and leaving air temp controls at 85～95 DEG C, and the intrinsic pressure power of tower is maintained at-5mmH2O。
In step (3), as preferably, the nip pressure of dry granulation is 60Pa～80Pa, and pressure roller rotating speed is 10 revs/min～16 revs/min, and mixture transfer rate is 45 revs/min～65 revs/min.
Present invention also offers a kind of honeysuckle flower common cold granule, above-mentioned preparation method prepare.This honeysuckle flower common cold granule mouthfeel is good, easily absorbs.
Medical material of the present invention is described in detail below:
Flos Lonicerae is the perennial half evergreen winding bejuco of Caprifoliaceae, has heat-clearing and toxic substances removing, dispelling wind and heat pathogens.For the furuncle that bitterly swells, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Fructus Forsythiae is the fruit of Oleaceae plants Fructus Forsythiae, has heat-clearing and toxic substances removing, detumescence heat radiation, dispelling wind and heat pathogens.For carbuncle, scrofula, mastalgia, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm is joined the army, high hot excessive thirst, and coma sends out speckle, the puckery pain of pyretic stranguria.
Radix Saposhnikoviae is the dry root of umbelliferae Saposhnikovia divaricata, has bent wind antipyretic, removing dampness to relieve pain, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Radix Platycodonis is campanulaceae Platycodon grandiflouorum plant, has lung qi dispersing, eliminates the phlegm, sore-throat relieving, the function such as evacuation of pus, for cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia hoarseness, pain in the lung vomiting pus.
Radix Glycyrrhizae is glycyrrhizic legume, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, wrist abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
The present invention advantage be in that:
The mouthfeel of honeysuckle flower common cold granule own is very pained, and the present invention works as correctives with adjuvant steviosin, covers its bitterness, and prepared products taste is best, selects dextrin to granulate with maltodextrin simultaneously, and melting is better.Again through by raw material with dynamic agitation mode steaming and decocting, make extraction concentrate a step and complete, be greatly saved raw material and working time, improve the valid density of extracting solution.Preparation method is simple, and with short production cycle, it is not necessary to any special installation, cost is low, is suitable to industrialized production.
Detailed description of the invention
Embodiment 1
Prescription: in 1000 bags (specifications: 3g/ bag)
Operating procedure:
(1) in extraction pot, add the hot water of medical material 3 times amount about 80 DEG C in advance, Flos Lonicerae 3520g, Radix Glycyrrhizae 1750g being added in extraction pot, be supplemented with hot water to medical material 10 times amount, water heats to 95 DEG C, extract 2 hours with 50 turns/min stirring dynamic, obtain the first extracting solution；Again Fructus Forsythiae 3520g, Radix Saposhnikoviae 3520g, Radix Platycodonis 3520g are put in extraction pot, at 85 DEG C of temperature, extract 2 hours with 45 turns/min stirring dynamic with the water of medical material weight 9 times amount, obtain the second extracting solution, by the first extracting solution and the blended filtration of the second extracting solution, filtrate is put in supercentrifuge, carry out ultracentrifugation, and the concentration of filtrate low pressure (vacuum-0.075MPa, temperature is 70 DEG C, concentrated solution relative density is 1.20), standby；
(2) concentrated solution adds isopyknic ethanol, stirs evenly, stands 12 hours, filters, and filtrate recycling ethanol is also concentrated into relative density about 1.10 (60 DEG C).Adopting moment spray drying, inlet temperature controls at 185 DEG C, and leaving air temp controls at 90 DEG C, and the intrinsic pressure power of tower is maintained at-5mmH2O, obtains dried cream powder 3556g；
(3) spray drying gained dried cream powder adds dextrin 6g, maltodextrin 2g, steviosin 4g pour in mixer and mix 20 minutes.With dry granulation, nip pressure is 75Pa, and pressure roller rotating speed is 12 revs/min, and mixture transfer rate is 55 revs/min.Granule after granulation crosses shaking screen, obtains honeysuckle flower common cold granule.
Embodiment 2
Prescription: in 1000 bags (specifications: 3g/ bag)
Operating procedure:
(1) in extraction pot, add the hot water of medical material 3 times amount about 80 DEG C in advance, Flos Lonicerae 3520g, Radix Glycyrrhizae 1750g being added in extraction pot, be supplemented with hot water to medical material 10 times amount, water heats to 98 DEG C, extract 2 hours with 55 turns/min stirring dynamic, obtain the first extracting solution.Again Fructus Forsythiae 3520g, Radix Saposhnikoviae 3520g, Radix Platycodonis 3520g are put in extraction pot, at 80 DEG C of temperature, extract 2 hours with 50 turns/min stirring dynamic with the water of medical material weight 8 times amount, obtain the second extracting solution.By the first extracting solution and the blended filtration of the second extracting solution, filtrate is put in supercentrifuge, carries out ultracentrifugation, filtrate low pressure concentration (vacuum-0.08MPa, temperature is 65 DEG C, and concentrated solution relative density is 1.20), standby；
(2) concentrated solution adds isopyknic ethanol, stirs evenly, stands 12 hours, filters, and filtrate recycling ethanol is also concentrated into relative density about 1.10 (60 DEG C).Adopting moment spray drying, inlet temperature controls at 180 DEG C, and leaving air temp controls at 93 DEG C, and the intrinsic pressure power of tower is maintained at-5mmH2O, obtains dried cream powder 3528g；
(3) spray drying gained dried cream powder adds dextrin 9g, maltodextrin 3g, steviosin 3g pour in mixer and mix 20 minutes.With dry granulation, nip pressure is 70Pa, and pressure roller rotating speed is 12 revs/min, and mixture transfer rate is 55 revs/min.Granule after granulation crosses shaking screen, obtains honeysuckle flower common cold granule.
Embodiment 3
Prescription: in 1000 bags (specifications: 3g/ bag)
Operating procedure:
(1) in extraction pot, add the hot water of medical material 3 times amount about 80 DEG C in advance, Flos Lonicerae 3520g, Radix Glycyrrhizae 1750g being added in extraction pot, be supplemented with hot water to medical material 11 times amount, water heats to 93 DEG C, extract 2 hours with 60 turns/min stirring dynamic, obtain the first extracting solution.Again Fructus Forsythiae 3520g, Radix Saposhnikoviae 3520g, Radix Platycodonis 3520g are put in extraction pot, at 80 DEG C of temperature, extract 2 hours with 40 turns/min stirring dynamic with the water of medical material weight 8 times amount, obtain the second extracting solution.By the first extracting solution and the blended filtration of the second extracting solution, filtrate is put in supercentrifuge, carries out ultracentrifugation, filtrate low pressure concentration (vacuum-0.07MPa, temperature is 75 DEG C, and concentrated solution relative density is 1.20), standby；
(2) concentrated solution adds isopyknic ethanol, stirs evenly, stands 12 hours, filters, and filtrate recycling ethanol is also concentrated into relative density about 1.10 (60 DEG C).Adopting moment spray drying, inlet temperature controls at 190 DEG C, and leaving air temp controls at 80 DEG C, and the intrinsic pressure power of tower is maintained at-5mmH2O, obtains dried cream powder 3563g；
(3) spray drying gained dried cream powder adds dextrin 12g, maltodextrin 4g, steviosin 5g pour in mixer and mix 20 minutes.With dry granulation, nip pressure is 80Pa, and pressure roller rotating speed is 12 revs/min, and mixture transfer rate is 55 revs/min.Granule after granulation crosses shaking screen, obtains honeysuckle flower common cold granule.
Comparative example 1
Prescription: in 1000 bags (specifications: 3g/ bag)
Operating procedure:
Except being added without dextrin, other same embodiment 1.
Comparative example 2
Prescription: in 1000 bags (specifications: 3g/ bag)
Operating procedure:
Except adding into maltodextrin, other same embodiment 1.
Comparative example 3
Prescription: in 1000 bags (specifications: 3g/ bag)
Operating procedure:
(1) medical material Flos Lonicerae 3520g, Fructus Forsythiae 3520g, Radix Saposhnikoviae 3520g, Radix Platycodonis 3520g, Radix Glycyrrhizae 1750g boiling secondary are measured, 3 hours first times, the first time consumption of water is medical material 10 times amount, second time 2 hours, the consumption of second time water is medical material 8 times amount, and collecting decoction filters.Filtrate is put in supercentrifuge, carry out ultracentrifugation, filtrate low pressure concentration (vacuum-0.08MPa, temperature is 65 DEG C, and concentrated solution relative density is 1.20), standby；
(2) concentrated solution adds isopyknic ethanol, stirs evenly, stands 12 hours, filters, and filtrate recycling ethanol is also concentrated into relative density about 1.10 (60 DEG C).Adopting moment spray drying, inlet temperature controls at 180 DEG C, and leaving air temp controls at 93 DEG C, and the intrinsic pressure power of tower is maintained at-5mmH2O, obtains dried cream powder 2311g；
(3) spray drying gained dried cream powder adds dextrin 0.6g, maltodextrin 0.2g, steviosin 0.4g pour in mixer and mix 20 minutes.With dry granulation, nip pressure is 75Pa, and pressure roller rotating speed is 12 revs/min, and mixture transfer rate is 55 revs/min.Granule after granulation crosses shaking screen, obtains honeysuckle flower common cold granule.
Comparative example 4
Prescription: in 1000 bags (specifications: 3g/ bag)
Operating procedure:
(1) medical material Flos Lonicerae 3520g, Fructus Forsythiae 3520g, Radix Saposhnikoviae 3520g, Radix Platycodonis 3520g, Radix Glycyrrhizae 1750g boiling secondary are measured, 3 hours first times, the first time consumption of water is medical material 10 times amount, second time 2 hours, the first time consumption of water is medical material 8 times amount, and collecting decoction filters.Filtrate is put in supercentrifuge, carry out ultracentrifugation, filtrate low pressure concentration (vacuum-0.08MPa, temperature is 65 DEG C, and concentrated solution relative density is 1.20), standby；
(2) concentrated solution adds isopyknic ethanol, stirs evenly, stands 12 hours, filters, and filtrate recycling ethanol is also concentrated into relative density about 1.10 (60 DEG C).Adopting moment spray drying, inlet temperature controls at 180 DEG C, and leaving air temp controls at 93 DEG C, and the intrinsic pressure power of tower is maintained at-5mmH2O, obtains dried cream powder 2394g；
(3) spray drying gained dried cream powder add starch 18g pour in mixer mix 30 minutes.With dry granulation, nip pressure is 75Pa, and pressure roller rotating speed is 12 revs/min, and mixture transfer rate is 55 revs/min.Granule after granulation crosses shaking screen, obtains honeysuckle flower common cold granule.
The thin layer of Flos Lonicerae differentiates: takes compound honeysuckle cold granules 5g, adds methanol 5mL, supersound process 20min, filters, and filtrate is as need testing solution.And the negative control solution of Flos Lonicerae is lacked with method preparation.Separately take chlorogenic acid reference substance, add methanol and make the lml solution containing lmg, as reference substance solution.Test according to thin layer chromatography (one annex VIB of " Chinese Pharmacopoeia " version in 2010) 12, draw above-mentioned three kinds of each 10ul of solution, put respectively in same with sodium carboxymethyl cellulose for the silica gel g thin-layer plate of binding agent, with the upper solution of acetic acid fourth vinegar-formic acid-water (7:25:.25) for developing solvent, launch, take out, dry, put and inspect under ultra-violet lamp (365nm).In test sample chromatograph, on position corresponding with chlorogenic acid reference substance chromatograph, the fluorescence speckle of aobvious same color.
According to version " Chinese Pharmacopoeia " two annex IX methods in 2005, the honeysuckle flower common cold granule of embodiment 1～3 preparation and the honeysuckle flower common cold granule of comparative example 1～4 preparation are carried out quality inspection, the testing result such as following table of detection projects:
Every testing data of honeysuckle flower common cold granule
Testing data from table 1 is known, embodiment 1,2,3 mouthfeel, melting, loss on drying, stability are superior to comparative example 1,2,3,4, and the present invention is with short production cycle, quality controllable, be beneficial to saving cost, and simple to operate, meet industrialization production requirements, be better than existing preparation method.
Claims (10)
1. a honeysuckle flower common cold granule, it is characterised in that be made up of the medical material of following weight portion and adjuvant:
2. honeysuckle flower common cold granule according to claim 1, it is characterised in that described dextrin and the ratio of maltodextrin are 3:1.
3. honeysuckle flower common cold granule according to claim 1, it is characterised in that described medical material and the weight portion of adjuvant are as follows:
4. a honeysuckle flower common cold granule, it is characterised in that in 1000 bags, be made up of following medical material and adjuvant:
5. a honeysuckle flower common cold granule, it is characterised in that in 1000 bags, be made up of following medical material and adjuvant:
6. a honeysuckle flower common cold granule, it is characterised in that in 1000 bags, be made up of following medical material and adjuvant:
7. the preparation method of the honeysuckle flower common cold granule as described in any one of claim 1～6, it is characterised in that comprise the following steps:
(1) at 90-98 DEG C of temperature, with the water of medical material weight 9-11 times amount, Flos Lonicerae, Radix Glycyrrhizae are carried out dynamic extraction, control rotating speed be 50～60 turns/min, 2-3 hour after obtain the first extracting solution；Again at 80-90 DEG C of temperature, with the water of medical material weight 8-10 times amount, Radix Saposhnikoviae, Radix Platycodonis and Fructus Forsythiae carried out dynamic extraction, control rotating speed be 40～50 turns/min, 2-3 hour after obtain the second extracting solution；After described first extracting solution and the second extracting solution being merged, after filtration, ultracentrifugation and low pressure concentration, obtain the first concentrated solution；
(2) adding isopyknic ethanol in the first concentrated solution obtained to step (1), stir evenly, stand 10-12 hour, filter, filtrate recycling ethanol is also concentrated into the second concentrated solution that relative density is 1.0-1.2；The second concentrated solution obtained obtains dried cream powder through spray drying method；
(3) step (2) gained dried cream powder adding adjuvant and pours mixing 20-30 minute in mixer into, with dry granulation, the granule after granulation crosses shaking screen, obtains described honeysuckle flower common cold granule.
8. the preparation method of honeysuckle flower common cold granule according to claim 7, it is characterized in that, in step (1), the vacuum of low pressure concentration is-0.07～-0.08MPa, temperature is 65～75 DEG C, and the first concentrated solution relative density obtained is 1.20～1.25g/cm3。
9. the preparation method of honeysuckle flower common cold granule according to claim 7, it is characterised in that in step (2), the inlet temperature of spray drying method controls at 180～190 DEG C, and leaving air temp controls at 85～95 DEG C, and the intrinsic pressure power of tower is maintained at-5mmH2O。
10. the preparation method of honeysuckle flower common cold granule according to claim 7, it is characterized in that, in step (3), the nip pressure of dry granulation is 60Pa～80Pa, pressure roller rotating speed is 10 revs/min～16 revs/min, and mixture transfer rate is 45 revs/min～65 revs/min.
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| CN1899551A (en) * | 2006-07-13 | 2007-01-24 | 广东化州中药厂制药有限公司 | Sugar-free type red tangerine peel granular agent for treating productive cough |
| CN101433594A (en) * | 2007-11-15 | 2009-05-20 | 湖北广仁药业有限公司 | Sugar-free honeysuckle flower common cold granule |
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| CN1899551A (en) * | 2006-07-13 | 2007-01-24 | 广东化州中药厂制药有限公司 | Sugar-free type red tangerine peel granular agent for treating productive cough |
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