CN105722812B - 前列环素类似物的胺盐 - Google Patents
前列环素类似物的胺盐 Download PDFInfo
- Publication number
- CN105722812B CN105722812B CN201480062328.4A CN201480062328A CN105722812B CN 105722812 B CN105722812 B CN 105722812B CN 201480062328 A CN201480062328 A CN 201480062328A CN 105722812 B CN105722812 B CN 105722812B
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- chemical formula
- alkyl
- produce
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *Oc1*(CC=C)c(CO)ccc1 Chemical compound *Oc1*(CC=C)c(CO)ccc1 0.000 description 29
- XFGMSBXBHDQUEZ-CIIGPRGZSA-N CCCCCC(C)CC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1OCC(O)=O Chemical compound CCCCCC(C)CC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1OCC(O)=O XFGMSBXBHDQUEZ-CIIGPRGZSA-N 0.000 description 1
- QBJMROAICZEASC-XAPVIXHLSA-N CCCCC[C@@H](CC[C@H]([C@@H](Cc1c(CC=N)c(OCC(O)=O)ccc1)CC1)[C@@H]1O)O Chemical compound CCCCC[C@@H](CC[C@H]([C@@H](Cc1c(CC=N)c(OCC(O)=O)ccc1)CC1)[C@@H]1O)O QBJMROAICZEASC-XAPVIXHLSA-N 0.000 description 1
- IPGFEAXZBBFTFN-UHFFFAOYSA-N [O-][N+](c1cc(C(OCC2OC2)=O)cc([N+]([O-])=O)c1)=O Chemical compound [O-][N+](c1cc(C(OCC2OC2)=O)cc([N+]([O-])=O)c1)=O IPGFEAXZBBFTFN-UHFFFAOYSA-N 0.000 description 1
- IPGFEAXZBBFTFN-SECBINFHSA-N [O-][N+](c1cc(C(OC[C@@H]2OC2)=O)cc([N+]([O-])=O)c1)=O Chemical compound [O-][N+](c1cc(C(OC[C@@H]2OC2)=O)cc([N+]([O-])=O)c1)=O IPGFEAXZBBFTFN-SECBINFHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361903730P | 2013-11-13 | 2013-11-13 | |
| US61/903,730 | 2013-11-13 | ||
| PCT/US2014/064519 WO2015073314A1 (en) | 2013-11-13 | 2014-11-07 | Amine salts of a prostacyclin analog |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105722812A CN105722812A (zh) | 2016-06-29 |
| CN105722812B true CN105722812B (zh) | 2018-11-16 |
Family
ID=51982791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480062328.4A Expired - Fee Related CN105722812B (zh) | 2013-11-13 | 2014-11-07 | 前列环素类似物的胺盐 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9890104B2 (https=) |
| EP (1) | EP3068752A1 (https=) |
| JP (1) | JP6373378B2 (https=) |
| KR (1) | KR20160086837A (https=) |
| CN (1) | CN105722812B (https=) |
| AU (1) | AU2014349000B2 (https=) |
| CA (1) | CA2930574A1 (https=) |
| IL (1) | IL245357B (https=) |
| WO (1) | WO2015073314A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104837806A (zh) * | 2012-12-07 | 2015-08-12 | 开曼化学股份有限公司 | 前列环素类似物的合成方法 |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| KR101830693B1 (ko) * | 2016-04-28 | 2018-02-21 | 연성정밀화학(주) | 트레프로스티닐의 제조방법 및 이를 위한 중간체 |
| CN107602376A (zh) * | 2017-10-30 | 2018-01-19 | 上海泰坦科技股份有限公司 | 一种曲列前尼尔的合成方法 |
| AU2019344541B2 (en) | 2018-09-18 | 2022-01-06 | Eli Lilly And Company | Erbumine salt of treprostinil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6441245B1 (en) * | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| CN101903324A (zh) * | 2007-12-17 | 2010-12-01 | 联合治疗公司 | 一种制备Remodulin中的活性成分曲前列素的改良方法 |
| CN106038570A (zh) * | 2010-10-01 | 2016-10-26 | 丹麦国家医院 | 能够调节/保护内皮完整性的用于预防或治疗急性创伤性凝血病和心脏骤停复苏的化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| JPH09100294A (ja) * | 1995-10-02 | 1997-04-15 | Tsumura & Co | 血管新生阻害剤 |
| US6700025B2 (en) | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| WO2011153363A1 (en) | 2010-06-03 | 2011-12-08 | United Therapeutics Corporation | Treprostinil production |
| CA2710726C (en) | 2010-07-22 | 2016-02-23 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
| CN104837806A (zh) * | 2012-12-07 | 2015-08-12 | 开曼化学股份有限公司 | 前列环素类似物的合成方法 |
-
2014
- 2014-11-07 WO PCT/US2014/064519 patent/WO2015073314A1/en not_active Ceased
- 2014-11-07 JP JP2016530933A patent/JP6373378B2/ja not_active Expired - Fee Related
- 2014-11-07 KR KR1020167012739A patent/KR20160086837A/ko not_active Withdrawn
- 2014-11-07 US US15/036,219 patent/US9890104B2/en not_active Expired - Fee Related
- 2014-11-07 AU AU2014349000A patent/AU2014349000B2/en not_active Ceased
- 2014-11-07 EP EP14803019.0A patent/EP3068752A1/en not_active Withdrawn
- 2014-11-07 CN CN201480062328.4A patent/CN105722812B/zh not_active Expired - Fee Related
- 2014-11-07 CA CA2930574A patent/CA2930574A1/en not_active Abandoned
-
2016
- 2016-05-01 IL IL24535716A patent/IL245357B/en not_active IP Right Cessation
-
2017
- 2017-12-22 US US15/852,922 patent/US10155716B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6441245B1 (en) * | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| CN101903324A (zh) * | 2007-12-17 | 2010-12-01 | 联合治疗公司 | 一种制备Remodulin中的活性成分曲前列素的改良方法 |
| CN106038570A (zh) * | 2010-10-01 | 2016-10-26 | 丹麦国家医院 | 能够调节/保护内皮完整性的用于预防或治疗急性创伤性凝血病和心脏骤停复苏的化合物 |
Non-Patent Citations (1)
| Title |
|---|
| The Intramolecular Asymmetric Pauson-Khand Cyclization as a Novel and General Stereoselective Route to Benzindene Prostacyclins: Synthesis of UT-15 (Treprostinil);Robert M. Moriarty等;《J. Org. Chem.》;20041231;第69卷;第1890-1902页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016537363A (ja) | 2016-12-01 |
| US20180118656A1 (en) | 2018-05-03 |
| US9890104B2 (en) | 2018-02-13 |
| US10155716B2 (en) | 2018-12-18 |
| EP3068752A1 (en) | 2016-09-21 |
| IL245357A0 (en) | 2016-06-30 |
| KR20160086837A (ko) | 2016-07-20 |
| JP6373378B2 (ja) | 2018-08-15 |
| AU2014349000A1 (en) | 2016-06-09 |
| US20160289158A1 (en) | 2016-10-06 |
| AU2014349000B2 (en) | 2019-01-17 |
| WO2015073314A1 (en) | 2015-05-21 |
| CN105722812A (zh) | 2016-06-29 |
| CA2930574A1 (en) | 2015-05-21 |
| IL245357B (en) | 2019-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181116 Termination date: 20201107 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |