CN105722543B - 通过雾化施用肺表面活性剂的改进的方法和系统 - Google Patents
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- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
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Abstract
Description
Claims (15)
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EP13189768.8 | 2013-10-22 | ||
EP13189768 | 2013-10-22 | ||
PCT/EP2014/072278 WO2015059037A1 (en) | 2013-10-22 | 2014-10-16 | Improved method and system for the administration of a pulmonary surfactant by atomization |
Publications (2)
Publication Number | Publication Date |
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CN105722543A CN105722543A (zh) | 2016-06-29 |
CN105722543B true CN105722543B (zh) | 2019-05-03 |
Family
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CN201480062040.7A Active CN105722543B (zh) | 2013-10-22 | 2014-10-16 | 通过雾化施用肺表面活性剂的改进的方法和系统 |
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US (1) | US11197965B2 (zh) |
EP (1) | EP3060282B1 (zh) |
CN (1) | CN105722543B (zh) |
AR (1) | AR098146A1 (zh) |
ES (1) | ES2712600T3 (zh) |
PL (1) | PL3060282T3 (zh) |
RU (1) | RU2671205C2 (zh) |
TR (1) | TR201900557T4 (zh) |
TW (1) | TW201609206A (zh) |
WO (1) | WO2015059037A1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101861078B1 (ko) * | 2016-03-29 | 2018-05-28 | (주)엘메카 | 네트워크를 통한 의료용 석션기의 관리 방법 및 이에 사용되는 관리 서버 |
CA3028551A1 (en) | 2016-07-28 | 2018-02-01 | Chiesi Farmaceutici S.P.A. | Method and system for delivery of an aerosolized medicament |
CN110087718A (zh) * | 2016-12-13 | 2019-08-02 | 库尔诊疗公司 | 肺部系统中的密相材料运输 |
PL3756710T3 (pl) | 2018-08-07 | 2022-09-19 | Feellife Health Inc. | Przenośne urządzenie rozpylające przeznaczone do oddziałów intensywnej opieki medycznej umożliwiające autonomiczne oddychanie odpowiednio do przepływu powietrza |
US20220008672A1 (en) * | 2018-12-06 | 2022-01-13 | Stamford Devices Limited | Aerosolised medication of ventilated patients with minimised dead volume |
WO2021029849A1 (en) * | 2019-08-09 | 2021-02-18 | Ony Biotech Inc. | Medicament delivery device |
FR3105004B1 (fr) | 2019-12-18 | 2023-10-27 | Univ Bordeaux | Cathéter pour l’administration d’une pulverisation médicamenteuse dans la trachée d’un sujet |
CN112023201B (zh) * | 2020-09-09 | 2022-08-19 | 丽水市中心医院 | 新生儿气管内给药导管 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5313939A (en) * | 1991-10-11 | 1994-05-24 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Endotracheal™ tube for topical substance delivery and associated method of use |
CN1528475A (zh) * | 2003-10-21 | 2004-09-15 | 王永国 | 一种气管导管引导管 |
CN1867370A (zh) * | 2004-01-20 | 2006-11-22 | 霍弗里希特有限公司 | 用于治疗睡眠窒息的呼吸装置及其控制方法 |
CN101460212A (zh) * | 2006-06-05 | 2009-06-17 | 雷斯梅德有限公司 | 用于治疗睡眠呼吸障碍的需要较少校准的装置或价格低廉的校准装置的系统和/或方法 |
CN101657227A (zh) * | 2006-12-14 | 2010-02-24 | 阿奇博尔德·伊安·杰里米·布雷恩 | 具有药物递送设备的喉罩导气装置 |
CN102989065A (zh) * | 2012-11-13 | 2013-03-27 | 浦易(上海)生物技术有限公司 | 一种用于治疗鼻窦炎或过敏性鼻炎的喷药装置 |
CN103282069A (zh) * | 2010-10-20 | 2013-09-04 | 沃尔夫托瑞医药公司 | 小型流体雾化器 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3794026A (en) * | 1970-07-29 | 1974-02-26 | H Jacobs | Ventilating apparatus embodying selective volume or pressure operation and catheter means for use therewith |
US4567882A (en) * | 1982-12-06 | 1986-02-04 | Vanderbilt University | Method for locating the illuminated tip of an endotracheal tube |
US4621646A (en) * | 1983-12-15 | 1986-11-11 | The United States Of America As Represented By The Secretary Of The Army | Blood flow measuring method |
US4813431A (en) * | 1987-07-22 | 1989-03-21 | David Brown | Intrapulmonary pressure monitoring system |
US4787894A (en) * | 1987-10-26 | 1988-11-29 | Turnbull Christopher J | Meconium aspiration device |
EP0758257B1 (en) * | 1994-05-06 | 2000-02-23 | Mark Brauner | Apparatus for intrapulmonary therapy and drug administration |
IL114154A0 (en) | 1994-06-17 | 1995-10-31 | Trudell Medical Ltd | Nebulizing catheter system and methods of use and manufacture |
DE19547538C2 (de) * | 1995-12-20 | 1999-09-23 | Ruesch Willy Ag | Instrument zur Anwendung bei einer interventionellen flexiblen Tracheo-/Bronchoskopie |
RU2149015C1 (ru) * | 1999-07-01 | 2000-05-20 | Центральный научно-исследовательский рентгенорадиологический институт | Способ лечения постнатальных пневмоний у новорожденных |
US6315739B1 (en) * | 1999-09-27 | 2001-11-13 | Instrumentarium Corporation | Apparatus and method for measuring the intratracheal pressure of an intubated patient |
US6536437B1 (en) * | 1999-10-29 | 2003-03-25 | Branislav M. Dragisic | Cuffed nasal airway and anesthetic wand system |
US6450164B1 (en) * | 2000-08-17 | 2002-09-17 | Michael J. Banner | Endotracheal tube pressure monitoring system and method of controlling same |
DE602005014219D1 (de) * | 2004-03-31 | 2009-06-10 | Terumo Corp | Katheterverpackungskörper |
US8146400B2 (en) * | 2004-04-21 | 2012-04-03 | Acclarent, Inc. | Endoscopic methods and devices for transnasal procedures |
GB0505724D0 (en) * | 2005-03-19 | 2005-04-27 | Smiths Group Plc | Tracheostomy tubes |
US7824436B2 (en) * | 2005-05-13 | 2010-11-02 | Benechill, Inc. | Methods and devices for non-invasive cerebral and systemic cooling |
US9358150B2 (en) * | 2005-05-13 | 2016-06-07 | Benechill, Inc. | Methods and devices for non-invasive cerebral and systemic cooling alternating liquid mist/gas for induction and gas for maintenance |
WO2007023492A2 (en) * | 2005-08-24 | 2007-03-01 | Hospitech Respiration Ltd. | Adjustment of endotracheal tube cuff filling |
US8303531B2 (en) * | 2008-02-11 | 2012-11-06 | Nordson Corporation | Spray applicator with positionable spray tip |
MX2010010139A (es) * | 2008-03-17 | 2011-02-21 | Discovery Lab Inc | Adaptador de circuito de ventilacion y sistema proximo de suministro en aerosol. |
EP2373234A1 (en) * | 2008-12-16 | 2011-10-12 | Aardvark Medical, Inc. | Methods and systems for delivery of fluids, aerosols and acoustic energy to tissue surfaces, cavities and obstructed passages such as intranasal ostia |
US20110112469A1 (en) * | 2009-11-08 | 2011-05-12 | Powerscope Incorporated | Device and process for dispensing multiple-phase mixtures |
AU2012286892B2 (en) * | 2011-07-25 | 2016-04-21 | Neurosave, Inc. | Non-invasive systems, devices, and methods for selective brain cooling |
WO2013090619A1 (en) * | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Devices and methods for preventing tracheal aspiration |
CN104321103B (zh) * | 2012-04-23 | 2017-04-26 | 奇斯药制品公司 | 用于通过雾化给入肺表面活性物质的方法和系统 |
-
2014
- 2014-10-14 TW TW103135442A patent/TW201609206A/zh unknown
- 2014-10-16 RU RU2016114403A patent/RU2671205C2/ru active
- 2014-10-16 EP EP14784487.2A patent/EP3060282B1/en active Active
- 2014-10-16 TR TR2019/00557T patent/TR201900557T4/tr unknown
- 2014-10-16 ES ES14784487T patent/ES2712600T3/es active Active
- 2014-10-16 CN CN201480062040.7A patent/CN105722543B/zh active Active
- 2014-10-16 US US15/028,670 patent/US11197965B2/en active Active
- 2014-10-16 PL PL14784487T patent/PL3060282T3/pl unknown
- 2014-10-16 WO PCT/EP2014/072278 patent/WO2015059037A1/en active Application Filing
- 2014-10-22 AR ARP140103961A patent/AR098146A1/es active IP Right Grant
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5313939A (en) * | 1991-10-11 | 1994-05-24 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Endotracheal™ tube for topical substance delivery and associated method of use |
CN1528475A (zh) * | 2003-10-21 | 2004-09-15 | 王永国 | 一种气管导管引导管 |
CN1867370A (zh) * | 2004-01-20 | 2006-11-22 | 霍弗里希特有限公司 | 用于治疗睡眠窒息的呼吸装置及其控制方法 |
CN101460212A (zh) * | 2006-06-05 | 2009-06-17 | 雷斯梅德有限公司 | 用于治疗睡眠呼吸障碍的需要较少校准的装置或价格低廉的校准装置的系统和/或方法 |
CN101657227A (zh) * | 2006-12-14 | 2010-02-24 | 阿奇博尔德·伊安·杰里米·布雷恩 | 具有药物递送设备的喉罩导气装置 |
CN103282069A (zh) * | 2010-10-20 | 2013-09-04 | 沃尔夫托瑞医药公司 | 小型流体雾化器 |
CN102989065A (zh) * | 2012-11-13 | 2013-03-27 | 浦易(上海)生物技术有限公司 | 一种用于治疗鼻窦炎或过敏性鼻炎的喷药装置 |
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WO2015059037A1 (en) | 2015-04-30 |
RU2671205C2 (ru) | 2018-10-30 |
RU2016114403A3 (zh) | 2018-05-21 |
US11197965B2 (en) | 2021-12-14 |
AR098146A1 (es) | 2016-05-04 |
CN105722543A (zh) | 2016-06-29 |
TW201609206A (zh) | 2016-03-16 |
EP3060282B1 (en) | 2018-12-05 |
PL3060282T3 (pl) | 2019-05-31 |
ES2712600T3 (es) | 2019-05-14 |
TR201900557T4 (tr) | 2019-02-21 |
EP3060282A1 (en) | 2016-08-31 |
US20160263333A1 (en) | 2016-09-15 |
RU2016114403A (ru) | 2017-11-28 |
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