CN105709103A - Health care type Huangshan florists chrysanthemum beverage and preparation method - Google Patents
Health care type Huangshan florists chrysanthemum beverage and preparation method Download PDFInfo
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- CN105709103A CN105709103A CN201610189898.0A CN201610189898A CN105709103A CN 105709103 A CN105709103 A CN 105709103A CN 201610189898 A CN201610189898 A CN 201610189898A CN 105709103 A CN105709103 A CN 105709103A
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- herba
- dendranthemamorifolium
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Abstract
The invention discloses a health care type Huangshan florists chrysanthemum beverage. The beverage comprises raw materials in parts by weight as follows: 20-50 parts of Huangshan florists chrysanthemum, 5-15 parts of Heliotropium indicum, 8-20 parts of common heron's bill herb, 10-20 parts of dwarf lilyturf tuber, 10-20 parts of mulberry leaves, 2-8 parts of Potamogeton distinctus, 10-20 parts of plantain herb, 10-20 parts of portulaca oleracea, 8-16 parts of herb of Indian Pentanema, 10-20 parts of finger citron, 3-13 parts of inula flower, 4-10 parts of orientvine stem, 10-20 parts of Chinese wolfberry root-bark, 10-20 parts of pipewort flower, 8-20 parts of Polygonum viviparum, 10-20 parts of Hibiscus sabdariffa, 10-20 parts of common selfheal fruit-spike and 10-20 parts of lalang grass rhizome, 6-20 parts of Ardisia maculosa Mez, 10-20 parts of Hemistepta lyrata and 10-20 parts of Leonurus japonicas. The beverage has the effects of nourishing the liver and the kidney, nourishing yin, enriching blood, tonifying deficiency, boosting essence and dispelling pathogenic wind for improving eyesight, is highly targeted and has a good health care effect on dry eyes caused by excessive eye use.
Description
Technical field
The present invention relates to a kind of health Dendranthemamorifolium beverage and preparation method, belong to functional drink field.
Background technology
The traditional Chinese medical science thinks that the liver being in charge of the eyes: " liver-QI being connected with eyes, liver and then order can distinguish the five colors ".The pathological changes of liver often affects and order.Such as deficiency of liver-blood, then two dryness and uneasy feeling of the eye, blurring of vision or nyctalopia;Wind-heat of liver channel, it is seen that conjunctival congestion is itched bitterly;Flaming up of liver-fire, it is seen that keratoconjunctivitis;Excessive rising of liver-YANG, the then vertigo;Liver-wind stirring up internally, it is seen that look on order is oblique." five kinds of impairments caused by overstrain " of Huangdi's Internal Classics there is a wound: " impairment of blood by looking for a long time ".Here blood, what refer to is exactly liver blood.
It practice, eyes and liver contact closely.Blood stored in the liver, namely liver has stored blood and regulates the function of blood volume, and liver opening at eye.Eyes are subject to the provisions of blood just can look thing, and excessively with eye, can make liver-blood deficiency, make binocular can not get the supply of nutrition, thus go out to lose face dry and astringent, see fuzzy, the nyctalopia of thing etc..It addition, long-term sitting eye, except binocular blood supply insufficiency, cervical vertebra, lumbar vertebra also can produce strain, less than alleviation, also can liver must be caused damage.In this case, eyes fatigue, visual deterioration, even shallow complexion, dizzy symptom occur, does not also just wonder.
Modern metropolitan cities working clan commonly uses computer office, and tobacco and wine are immoderate, and night life is uncontrolled, stays up late, and these have all directly injured irritability.Watching for a long time and radiation, the eye health for computer family has buried hidden danger.This kind of people needs hepatoprotective while noting eye hygiene to nourish blood.
Effect of Flos Chrysanthemi and effect: taste is micro-pungent, sweet, bitter, cold nature.Energy dispelling wind and heat pathogens, liver heat removing and eyesight improving, suppressing the hyperactive liver sun, removing toxic substances.For cold anemopyretic, heating giddy;Liver Channel has heat;The many tear of conjunctival congestion, or the hepatic and renal YIN deficiency, eyes is dim-sighted;Excessive rising of liver-YANG, dizziness and headache;Skin infection swells and ache.Modern times are again for coronary heart disease, hypertension.
Blood pressure lowering: Flos Chrysanthemi has blood pressure lowering, eliminates cancerous cell, coronary artery dilator and antibacterial effect, long-term drink can increase that human body is calcareous, regulate myocardial function, reduce cholesterol, drinks when being suitable for middle-aged and elderly people and prevention epidemic conjunctivitis.
Improving eyesight: Flos Chrysanthemi, except smearing eyes and can eliminating edema, usually can steep one cup of chrysanthemum scented tea and drink, can anti-eye strain.If drinking the chrysanthemum scented tea of 3-4 cup every day, also there is certain effect to recovering vision.
Refresh oneself: Flos Chrysanthemi is a kind of nerve tonic, can strengthen the resistance of blood capillary, delaying sanility, physical strength reinforcing.Flos Chrysanthemi has good sedation, often eats and people's limbs can be made light, refreshment.The nutritive value of Flos Chrysanthemi
The main component of Flos Chrysanthemi has volatile oil (0.20-/0-0.85%), adenine, choline, stachydrine, echinacoside and flavone compound.The volatile oil composition such as mainly have Borneolum Syntheticum, Camphora, chrysanthanone and acetic acid Borneolum Syntheticum cruel, flavones ingredient has luteolin, apigenin, acacetin etc..Additionally, possibly together with abundant vitamin, aminoacid, trace element etc. in Flos Chrysanthemi.
Various nourishing and protecting liver health product, medicine spread unchecked on the market now, but great majority are had a good apperance only, false propaganda on a grand scale, it is likely to there is no any health care, but causing the huge injury of the person, therefore, the health product of the effective hepatoprotective of search of health have very real significance.Chinese medicine hepatoprotective has advantage nontoxic, that can be fully absorbed by organism, is our Main way of studying.Modern metropolitan cities working clan commonly uses computer office watching for a long time, tobacco and wine are immoderate, the behavior of the injury livers such as night life is uncontrolled, stay up late, eyes are subject to the provisions of blood just can look thing, and excessively with eye, liver-blood deficiency can be made, make binocular can not get the supply of nutrition, thus go out to lose face dry and astringent, see fuzzy, the nyctalopia of thing etc..It addition, long-term sitting eye, except binocular blood supply insufficiency, cervical vertebra, lumbar vertebra also can produce strain, less than alleviation, also can liver must be caused damage.If probably being difficult to adhere to by Drug therapy merely, carelessly using collyrium more can make eyes damaged, causing various oculopathy or blind danger, and it is cumbersome to take Chinese medicine, mouthfeel is not good, unsuitable long-term taking, and effect is also not necessarily desirable.
Summary of the invention
For overcoming above-mentioned deficiency, the object of the invention one health Dendranthemamorifolium beverage, to deficiency of the yin of the liver, two dryness and uneasy feeling of the eye, visual deterioration;Flaming up of liver-fire, conjunctival congestion and swelling pain;Excess eye-using is caused that eyes are dry astringent has good health-care effect.
For solving above-mentioned technical problem, the solution of the present invention is as follows: a kind of health Dendranthemamorifolium beverage, described health Dendranthemamorifolium beverage includes the crude drug of following weight portion: Dendranthemamorifolium 20~50 parts, Herba Heliotroph 1~5 part, Herba Erodii 2~5 parts, Radix Ophiopogonis 1~5 part, 1~6 part of Folium Mori, Herba potamogetonis distincti 2~5 parts, Herba Plantaginis 3~6 parts, Herba Portulacae 2~8 parts, Herba Pentanematis Indici 1~4 part, Fructus Citri Sarcodactylis 1~6 part, Flos Inulae 1~6 part, Caulis Sinomenii 4~10 parts, Cortex Lycii 1~6 part, Flos Eriocauli 3~6 parts, Polygonum viviparum L. 1~6 part, Calyx Hibisci Sabdariffae 3~6 parts, Spica Prunellae 2~5 parts, Rhizoma Imperatae 2~8 parts, Herba Ardisiae Maculosae 1~4 part, Herba Hemisteptae Lyratae 2~5 parts, Herba Leonuri 2~8 parts.
Further, described health Dendranthemamorifolium beverage includes the crude drug of following weight portion: Dendranthemamorifolium 30~50 parts, Herba Heliotroph 2~5 parts, Herba Erodii 2~5 parts, Radix Ophiopogonis 1~5 part, 1~6 part of Folium Mori, Herba potamogetonis distincti 3~5 parts, Herba Plantaginis 4~6 parts, Herba Portulacae 2~8 parts, Herba Pentanematis Indici 1~4 part, Fructus Citri Sarcodactylis 2~6 parts, Flos Inulae 3~6 parts, Caulis Sinomenii 4~10 parts, Cortex Lycii 2~6 parts, Flos Eriocauli 3~6 parts, Polygonum viviparum L. 2~6 parts, Calyx Hibisci Sabdariffae 4~6 parts, Spica Prunellae 2~4 parts, Rhizoma Imperatae 2~6 parts, Herba Ardisiae Maculosae 2~4 parts, Herba Hemisteptae Lyratae 2~5 parts, Herba Leonuri 2~6 parts.
Further, described health Dendranthemamorifolium beverage includes the crude drug of following weight portion: Dendranthemamorifolium 45 parts, Herba Heliotroph 3 parts, Herba Erodii 4 parts, Radix Ophiopogonis 2 parts, 3 parts of Folium Mori, Herba potamogetonis distincti 4 parts, Herba Plantaginis 5 parts, Herba Portulacae 3 parts, Herba Pentanematis Indici 2 parts, Fructus Citri Sarcodactylis 4 parts, Flos Inulae 4 parts, Caulis Sinomenii 6 parts, Cortex Lycii 5 parts, Flos Eriocauli 4 parts, Polygonum viviparum L. 5 parts, Calyx Hibisci Sabdariffae 6 parts, Spica Prunellae 2 parts, Rhizoma Imperatae 3 parts, Herba Ardisiae Maculosae 3 parts, Herba Hemisteptae Lyratae 4 parts, Herba Leonuri 6 parts.
A kind of preparation method of health Dendranthemamorifolium beverage, the preparation method of described health Dendranthemamorifolium beverage comprises the following steps:
A. the extraction of Dendranthemamorifolium, as component one;
B. all the other crude drug described chopping is extracted as component two;
C. component one and component two are mixed, add proper honey after concentration and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.
Further, in described step a, the Dendranthemamorifolium of collection is steeped in 10 times amount ethanol after 2-7 days, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-110 order filters, the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 then through damming, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component one.
Further, in described step b, all the other raw medicinal materials are mixed, shredded 100~120 mesh sieves, after sieving, fine powder is standby, and coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, 15~30 days are impregnated together with more than 70 degree ethanol, 2 extracting solution each 1~2 hour, are merged and stand by then heating and refluxing extraction 2 times, filter, after separation, take filtrate;By filtered through gauze, adding 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, and being condensed into pasty state becomes component two.
The present invention uses Dendranthemamorifolium to be primary raw material.Plus some nourishing liver and kidney, liver heat removing and eyesight improving, the Chinese medicine that mouthfeel is light, combined effect, to deficiency of the yin of the liver, two dryness and uneasy feeling of the eye, visual deterioration;Flaming up of liver-fire, conjunctival congestion and swelling pain;Excess eye-using is caused that eyes are dry astringent has good health-care effect.The most mouthfeel of these medical materials that the present invention chooses is light, and drug effect is notable, it is possible to long-term taking, does not also affect Dendranthemamorifolium taste, makes people be prone to accept, it is possible to long-term taking.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Eyes and liver contact closely.Blood stored in the liver, namely liver has stored blood and regulates the function of blood volume, and liver opening at eye.Eyes are subject to the provisions of blood just can look thing, and excessively with eye, can make liver-blood deficiency, make binocular can not get the supply of nutrition, thus go out to lose face dry and astringent, see fuzzy, the nyctalopia of thing etc..It addition, long-term sitting eye, except binocular blood supply insufficiency, cervical vertebra, lumbar vertebra also can produce strain, less than alleviation, also can liver must be caused damage.In this case, eyes fatigue, visual deterioration, even shallow complexion, dizzy symptom occur, does not also just wonder.Watching for a long time and radiation, the eye health for computer family has buried hidden danger.
The traditional Chinese medical science thinks that the liver being in charge of the eyes: " liver-QI being connected with eyes, liver and then order can distinguish the five colors ".The pathological changes of liver often affects and order.Such as deficiency of liver-blood, then two dryness and uneasy feeling of the eye, blurring of vision or nyctalopia;Wind-heat of liver channel, it is seen that conjunctival congestion is itched bitterly;Flaming up of liver-fire, it is seen that keratoconjunctivitis;Excessive rising of liver-YANG, the then vertigo;Liver-wind stirring up internally, it is seen that look on order is oblique.
Liver controlling conveyance and dispersion, comprehensive physiological functions such as referring to irritability there is dredging, bar reaches, liter is sent out, freely let out.Ancients' rushing with bar soothing the liver as the catharsis function carrying out analogy liver with wood gas, therefore in the five elements, belonged to wood, therefore " the secret allusion quotation opinion of Plain Questions LINGLAN " is said: " liver person; organ of general considers and here ", " Plain Questions six saves state of internal organs opinion " is said: " liver person; source of endurance, the residence of soul is also ".The function of liver controlling conveyance and dispersion is mainly manifested in adjustment spirit feelings will, and facilitating digestion absorbs, and maintains operation three aspect of QI and blood, body fluid.
Liver opening at eye, it is foster that objective vision function relies primarily on moistening of the moon blood of liver;The passages through which vital energy circulates of liver is first line of a couplet order system again.Therefore, whether normal the function of liver is usually reflects on order.Such as: deficiency of liver-blood may occur in which blurred vision, nyctalopia;Deficiency of the yin of the liver, then two dryness and uneasy feeling of the eye, visual deterioration;Flaming up of liver-fire, then conjunctival congestion and swelling pain.The traditional Chinese medical science is emphasized, people wants frequent dispersing liver-energy, liver heat removing poison, drops liver-fire, nourishing the liver blood, and dispersing liver-energy can make whole body mechanism of qi catharsis unobstructed, without pox on internal not stifled then face;Liver heat removing poison can dissolve elimination internal pollution, and internal nontoxic then face is without dead color;Dropping liver-fire and can make internal equilibrium between yin and yang, internal not burnt then skin moisturizing is not dry;Nourishing the liver blood can nourish whole body internal organs, and liver blood is full, and then body surface gloss is flexible.Repairing damaged liver, make whole body mechanism of qi free flow of qi, the smooth and easy operation of whole body QI and blood, to reach soothing the liver skin care purpose.Toxigenic source is liver.When liver can not complete removing toxic substances work well, toxin is just stretched in vivo.First soothing the liver skin care starts with from liver health, allows the liver of health complete every removing toxic substances work, thoroughly cuts off toxin source, make appearance persistently beautiful.
The main component of Flos Chrysanthemi has volatile oil (0.20-/0-0.85%), adenine, choline, stachydrine, echinacoside and flavone compound.The volatile oil composition such as mainly have Borneolum Syntheticum, Camphora, chrysanthanone and acetic acid Borneolum Syntheticum cruel, flavones ingredient has luteolin, apigenin, acacetin etc..Additionally, possibly together with abundant vitamin, aminoacid, trace element etc. in Flos Chrysanthemi.Compendium of Material Medica: wind heat, ophthalmalgia is intended to de-, lacrimation, and foster order goes blind, does pillow improving eyesight." herbal classic ": all dizziness due to wind swell and ache, order is intended to de-, lacrimation, the dead flesh of skin, aversion to wind arthralgia chiefly caused by damp pathogen.For a long time clothes profit vim and vigour, make light of one's life by commiting suicide and resistance to always prolong life." not Lu ": treat lumbago and go happy, except irritable feverish sensation in the chest, pacifies the intestines and stomach, profit five pulse conditions of ZANG-organs, tune extremity.Amplification on Canon of Materia Medica: have modern times more than 20 to plant, only single leaf is spent little and yellow, and greenery color depth is little and thin, should wait and the person of opening is also.
Flos Chrysanthemi dispelling wind is more weak, and heat clearing away power is good, often joins Folium Mori for affection due to external wind and heat with using, it is possible to join Radix Scutellariae, Fructus Gardeniae controls the diseases such as intenseness of heat is fidgety.Flos Chrysanthemi controls conjunctival congestion and swelling pain, no matter belongs to liver-fire or wind heat causer, all can apply, because of this product can clearing away liver-fire, wind heat can be dissipated again, often coordinate that Periostracum Cicadae, Fructus Atriplicis Sibiricae are equivalent to be used.Such as deficiecny of liver-YIN, eyes is dim-sighted, then the polygamy Radix Rehmanniae, Fructus Lycii are equal to use.The merit of Flos Chrysanthemi heat-clearing and toxic substances removing is excellent, for surgery key medicine, is mainly used in the disease of pathopyretic ulcer, red and swollen heat pain, especially has good efficacy especially for the furuncle poison that swells and ache, and both oral administrations can mash again external application.Clinically often and the product fit applications of the heat-clearing and toxic substances removing such as Herba Violae, Herba Taraxaci.Flos Chrysanthemi energy pancake liver-yang, the vertigo that excessive rising of liver-YANG is caused, often apply with the compatibility such as Concha Margaritifera, Pueraria lobata.
Herba Heliotroph: bitter is flat.Heat-clearing and toxic substances removing.For pneumonia, pulmonary abscess, empyema, diarrhoea, dysentery, orchitis, diphtheria, oral erosion, carbuncle furuncle.
Herba Erodii: toil, flat.Dispel the wind, invigorate blood circulation, heat-clearing and toxic substances removing.Dispelling the wind and dampness pathogens pain, contracture is numb, carbuncle, traumatic injury, enteritis, dysentery." the southern regions of the Yunnan Province book on Chinese herbal medicine ": all wind skin of dispelling is itched.Controlling bones and muscles pain, phlegm-fire flaccidity is soft, brothers' clonic spasm of the muscle, numb, and diuresis rushes down bladder accumulated heat, attacks scattered all pyogenic infections from tumour or sore, moves back consumptive disease heat fever, controls the diseases such as wind-fire dental caries, varioliform exanthema mange.
Radix Ophiopogonis: hardship sweet, micro-, it is slightly cold.Lung moistening clears away heart-fire, purge heat and promote the production of body fluid, the preventing or arresting vomiting that reduces phlegm, control row water of coughing." Records of Tradition Chinese and Western Medicine in Combination " says it: " entering stomach with nourishing the stomach liquid, stimulating appetite, spleen is scattered is skillful in lung, Dingchuan relieving coughing to help more to enter spleen." traditional Chinese medical science thinks; Radix Ophiopogonis sweet in the mouth, micro-hardship, cold nature, return stomach, lung, heart channel; have effect of nourishing YIN and moistening the lung, reinforcing stomach reg fluid, the relieving restlessness that clears away heart-fire, for diseases such as dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, Tianjin wound are thirsty, interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Folium Mori: Folium Mori are the dried leaves of moraceae plants Mulberry.Gather after first frost, remove impurity, dry and obtain, be a kind of wind-heat-dispersing medicinal, both oral administrations, it is possible to external application.It is cold in nature, sweet in the mouth, hardship, has effect of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, can treat anemopyretic cold, lung-heat type cough, dizziness headache, the disease that conjunctival congestion is dim-sighted.In modern times, doctor trained in Western medicine uses Folium Mori and Folium Mori biological preparation as the medicine improving diabetes and other various difficult miscellaneous diseases, it is believed that its drug effect is extremely wide.There are clearing away lung-heat and moistening for dryness, cough-relieving, reduce phlegm and internal heat, reduce phlegm, control night sweat;Tonifying liver, liver heat removing and eyesight improving, treatment dizziness and blurred vision, insomnia, elimination eye strain;Detumescence, purify the blood ' treatment dysentery, stomachache, fat-reducing, except beriberi, sharp large and small intestinal;Anti-stress, removing heat from blood, blood pressure lowering, blood fat reducing, prevention myocardial infarction, cerebral hemorrhage, dispel headache, long hair;Blood sugar lowering, anti-sugar are sick.
Herba potamogetonis distincti: micro-hardship, cool.Heat-clearing and toxic substances removing, diuresis, removing food stagnancy.For acute conjunctivitis, jaundice, edema, leucorrhea, infantile malnutrition, ascariasis;Carbuncle furuncle and phyma poison is controlled in external.
Herba Plantaginis: Herba Plantaginis nature and flavor: sweet;Light;Cold nature.Gui Jing: return lung meridian;Liver Channel;Kidney channel;Bladder warp.Function: clearing away heat and promoting diuresis;Eliminating dampness by diuresis antidiarrheal;Improving eyesight;Eliminate the phlegm.Cure mainly: main dysuria;Stranguria with turbid discharge leukorrhagia;Edema distension;Heat-damp in summer dysentery;Conjunctival congestion is hidden from view;Expectorant heat syndrome cough is breathed heavily." property of medicine is fallen ": can remove pathogenic wind toxic, the liver affected by pathogenic wind heat, poison wind dotting punch order, swelling pain is hidden from view, headache lacrimation, removes irritable feverish sensation of chest and heart." Japan hanako materia medica ": diuresis drenches puckery, tonifying YANG.Control de-essence, vexed.The therapeutic method to keep the adverse QI flowing downwards." medicine origin ": main urinary obstruction;Lead little pathogenic heat in the bowels.
Herba Portulacae: Herba Portulacae, Classification system: PortulacaoleraceaL. is Portulacaceae annual herb plant.Plump succulence, without hair, high 10 ~ 30cm, is born in the area without shade such as roadside, field and ruins, flower garden.All there is distribution domestic various places.This kind is medicine food dual purpose plant.Herb hyoscine, has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, antiinflammatory, quenches the thirst, diuresis;Seed improving eyesight.Modern study, Herba Portulacae is possibly together with abundant SL3 fatty acid and vitamin A sample material.SL3 fatty acid is to form cell membrane, especially material necessary to brain cell membrane and eye cell membrane;Vitamin A sample material can maintain epithelial tissue such as skin, cornea and conjunctival normal function, participates in the synthesis of rhodopsin, strengthens retinal photoreceptor performance, also assists in internal many oxidizing processs.
Herba Pentanematis Indici: " Red River Chinese herbal medicine " is lightly seasoned, micro-cool.Heat-clearing and toxic substances removing, relieving stranguria by diuresis.
Fructus Citri Sarcodactylis: Fructus Citri Sarcodactylis root, stem, leaf, flower, fruit all can be used as medicine, pungent, bitter, sweet, warm, nontoxic;Enter liver, spleen, stomach three warp, have activating QI to eliminate phlegm, preventing or arresting vomiting relieving distension, the liver soothing and the spleen invigorating, the more kinds of medicinal function of stomach function regulating.The tracheitis of old people, asthma there is obvious mitigation;To the dyspepsia of common people, chest and abdomen feeling of distension and oppression, there is significantly more curative effect.Fructus Citri Sarcodactylis can be made into several kinds of Chinese medicinal materials, and clothes have the effect of health-care for a long time.The fruit of Fructus Citri Sarcodactylis and Fructus Sechii edulis, be a kind of cucurbitaceae vegetable kind.The clear and melodious succulence of Fructus Sechii edulis, delicious good to eat, nutritive value is higher, both can cook, and can work as again fruit and eat something rare, and is also a kind of stomach invigorating, the Chinese medicine regulated the flow of vital energy.Drink with the leaf of Fructus Citri Sarcodactylis, flower, fruit infusing drugs in wine of making tea, have effect of regulating qi-flowing for strengthening spleen, preventing phlegm from forming and stopping coughing, relaxing muscles and tendons to promote blood circulation.Fructus Sechii edulis fine and tender taste, containing moisture 90-92 gram in the fruit of every 100 grams of Fructus Sechii edulis, egg from matter 0.9-1.2 gram, carbohydrate 2.6-7.7 gram, vitamin C 12-22 milligram, carotene 20 microgram.The content of potassium is higher, up to 190 milligrams, and 0.1 milligram of riboflavin, calcium 500 milligrams, P 32 0 milligram, ferrum 40 milligrams, 10 milligrams of sodium, copper 0.03 milligram, 7 milligrams of magnesium, zinc 8.35 microgram, selenium 2.3 microgram.Additionally contain folic acid, pantothenic acid, nicotinic acid etc..The Seedling of Fructus Sechii edulis is also nutritious vegetable, is that various vegetables can not be compared.
Flos Inulae: bitter, pungent, salty, tepor.Return lung, spleen, stomach, large intestine channel.Sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.Knot, chest and diaphragm feeling of fullness, vomiting eructation is stored for cough due to wind and cold, general drink.
Caulis Sinomenii: bitter, pungent is flat.Return liver, spleen channel.Wind-damp dispelling, diuresis.Dispelling the wind and dampness pathogens arthralgia pain, the arthroncus of knee, edema, beriberi.
Cortex Lycii: Cortex Lycii heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quench one's thirst, hypertension, carbuncle, malignant boil." herbal classic ": " pathogen in main five, hankers quenching one's thirst, general arthralgia." " not Lu ": " main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and hisses suctions, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat."
Flos Eriocauli: Classification system: Eriocaulonbuergerianum is pungent sweet, cool;Wind and heat eliminating, improving acuity of vision and removing nebula.Cure mainly and control corneal nebula, night blindness, headache, toothache, sore throat, epistaxis.Wind heat conjunctival congestion and swelling pain, photophobia, nebula of looking unfamiliar film.The frivolous liter of this product dissipates, and kind evacuates head wind heat, improving acuity of vision and removing nebula, attacks caused conjunctival congestion and swelling pain, the many tear of photophobia, nebula of looking unfamiliar film person with controlling in wind heat, can with the compatibility such as Herba Schizonepetae, Semen Cassiae, Radix Gentianae, such as Flos Eriocauli soup." Kaibao Bencao ": " main treatment sore throat, tooth wind pain and all skin ulcer scabies." Compendium of Material Medica: " the light property of Flos Eriocauli body is floated, can the bright dividing line of up sun.All control all diseases in order, add and with it, very good.The merit of improving acuity of vision and removing nebula, seemingly on Flos Chrysanthemi also."
Polygonum viviparum L.: bitter, puckery is cool.Heat-clearing and toxic substances removing, dissipating blood stasis stops blooding.For tonsillitis, pharyngolaryngitis, enteritis, dysentery, leucorrhea, metrorrhagia, have blood in stool;Traumatic injury is controlled in external, carbuncle furuncle and phyma poison, traumatic hemorrhage.
Calyx Hibisci Sabdariffae refers generally to Hibiscus Sabdariffa Linn, Calyx Hibisci Sabdariffae, Chinese medicine name.For the root of Malvaceae plant Calyx Hibisci Sabdariffae, seed.Acid, cool.Gui Jing returns kidney channel.Effect astringing lung-QI and relieving cough, blood pressure lowering, relieves the effect of alcohol." Xinhua's book on Chinese herbal medicine outline " root, seed have diuresis, strong function
Spica Prunellae: pungent, bitter, cold.Return liver, gallbladder meridian, effect;Clearing away heat-fire, improving eyesight, mass dissipating and swelling eliminating.Conjunctival congestion and swelling pain, headache dizziness, order pearl nyctalgia.This product bitter cold master enters Liver Channel, and kind removing fire from the liver is with improving eyesight.With controlling flaming up of liver-fire, conjunctival congestion and swelling pain, Folium Mori, Flos Chrysanthemi, Semen Cassiae etc. can be joined medicinal.Among this product liver heat removing and eyesight improving, nourishing the liver of slightly holding concurrently, join Radix Angelicae Sinensis, Fructus Lycii, can be used for deficiecny of liver-YIN, ophthalmalgia, to night more particularly;Also Rhizoma Cyperi, Radix Glycyrrhizae use can be joined, as Spica Prunellae dissipates (" Zhang Shi doctor is logical ").
Rhizoma Imperatae: Chinese medicine name.For grass Herba Imperatae ImperatacylindricaBeauv.var.major(Nees) dry rhizome of C.E.Hubb..Spring, season in autumn two excavate, and clean, dry, and remove fibrous root and film quality sheath, are bundled into wisp.Return lung, stomach, bladder warp.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Cure mainly and spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, cough due to lung-heat, gastropyretic vomiting, jaundice due to damp-heat, edema oliguria, the puckery pain of pyretic stranguria.
Herba Ardisiae Maculosae: fiber crops are bitter, and temperature enters liver, kidney, lung meridian.Relaxing muscles and tendons and activating QI and blood in the collateral, bone and muscle strengthening, pharynx-clearing throat-benefiting.
Herba Hemisteptae Lyratae: acrid in the mouth;Bitter;Cold in nature.Heat-clearing and toxic substances removing;Mass dissipating and swelling eliminating.Main anal fistula;Carbuncle furuncle;Acute mastitis;Lymphadenitis;Rubella traffic rules are itched;Traumatic hemorrhage;Fracture.
Herba Leonuri: acrid in the mouth is bitter, cool, invigorates blood circulation, silt of dispelling, regulating menstruation, disappear water, treats menoxenia, and vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Herba Leonuri has inducing diuresis to remove edema, shrinks the effect of uterus effect, is that ancient Chinese medicine doctor is for treating gynopathic key medicine.Herba Leonuri can all herbal medicine, effective ingredient be Herba Leonuri element, Herba Leonuri is containing multiple alkaloid and benzoic acid, potassium chloride etc. such as leonurine, stachydrine, leonuridine, leonurinines.Motherwort formulation has the effect of excited animal uterus, similar to pituitrin, and there is strong and lasting excitation in uterus by Herba Leonuri extractum and decoct, not only can strengthen its contractility, can improve its tensity and shrinkage factor simultaneously.
Embodiment 1
Health Dendranthemamorifolium beverage, including the crude drug of following weight portion:
Dendranthemamorifolium 45 parts, Herba Heliotroph 3 parts, Herba Erodii 4 parts, Radix Ophiopogonis 2 parts, 3 parts of Folium Mori, Herba potamogetonis distincti 4 parts, Herba Plantaginis 5 parts, Herba Portulacae 3 parts, Herba Pentanematis Indici 2 parts, Fructus Citri Sarcodactylis 4 parts, Flos Inulae 4 parts, Caulis Sinomenii 6 parts, Cortex Lycii 5 parts, Flos Eriocauli 4 parts, Polygonum viviparum L. 5 parts, Calyx Hibisci Sabdariffae 6 parts, Spica Prunellae 2 parts, Rhizoma Imperatae 3 parts, Herba Ardisiae Maculosae 3 parts, Herba Hemisteptae Lyratae 4 parts, Herba Leonuri 6 parts.
Preparation method, comprises the following steps:
A. the Dendranthemamorifolium of collection is steeped in 10 times amount ethanol after 5 days, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 110 orders filter, the ultrafiltration post ultrafiltration that molecular weight is 8000 then through damming, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component one.
B. being mixed by all the other raw medicinal materials, shredded 110 mesh sieves, after sieving, fine powder is standby, and coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, impregnate together with more than 70 degree ethanol 20 days, then heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged and stands, filter, after separation, take filtrate;By filtered through gauze, adding 55% ethanol in residue, 65 DEG C are continued lixiviate 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, and being condensed into pasty state becomes component two.
C. component one and component two are mixed, add proper honey after concentration and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal, obtain health Dendranthemamorifolium beverage.
Embodiment 2
Health Dendranthemamorifolium beverage, including the crude drug of following weight portion:
Dendranthemamorifolium 40 parts, Herba Heliotroph 2 parts, Herba Erodii 3 parts, Radix Ophiopogonis 2 parts, 5 parts of Folium Mori, Herba potamogetonis distincti 3 parts, Herba Plantaginis 3 parts, Herba Portulacae 8 parts, Herba Pentanematis Indici 1 part, Fructus Citri Sarcodactylis 2 parts, Flos Inulae 5 parts, Caulis Sinomenii 4 parts, Cortex Lycii 5 parts, Flos Eriocauli 3 parts, Polygonum viviparum L. 2 parts, Calyx Hibisci Sabdariffae 4 parts, Spica Prunellae 4 parts, Rhizoma Imperatae 2 parts, Herba Ardisiae Maculosae 3 parts, Herba Hemisteptae Lyratae 3 parts, Herba Leonuri 5 parts.
Preparation method is with embodiment 1.
Embodiment 3
Health Dendranthemamorifolium beverage, including the crude drug of following weight portion:
Dendranthemamorifolium 33 parts, Herba Heliotroph 2 parts, Herba Erodii 2 parts, Radix Ophiopogonis 1 part, 4 parts of Folium Mori, Herba potamogetonis distincti 3 parts, Herba Plantaginis 3 parts, Herba Portulacae 2 parts, Herba Pentanematis Indici 4 parts, Fructus Citri Sarcodactylis 5 parts, Flos Inulae 2 parts, Caulis Sinomenii 4 parts, Cortex Lycii 2 parts, Flos Eriocauli 3 parts, Polygonum viviparum L. 1 part, Calyx Hibisci Sabdariffae 6 parts, Spica Prunellae 2 parts, Rhizoma Imperatae 5 parts, Herba Ardisiae Maculosae 2 parts, Herba Hemisteptae Lyratae 3 parts, Herba Leonuri 4 parts.
Preparation method is with embodiment 1.
Acute toxicity testing
One, test material:
Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Experiment thing: decoction liquor of the present invention.
Two, method:
1, LD50 calculates: adopt improvement karber's method, mice is randomly divided into 5 groups, often group 10, male and female half and half, add the embodiment of the present invention 1 distilled water and dissolve, be made into Cmax, by the maximum allowable capacity administration of mice, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), after animal fasting (can't help water) 18 hours, in one day, administration (interval half an hour) at twice, each 0.5ml, observe animal dead situation.
2, maximum tolerated dose measures (MTD value): take mice 20, each 10 of male and female.The present invention adds distilled water dissolve, be made into maximum concentration, by the maximum tolerated dose of animal, can twitch and be as the criterion inject filling hello device.After animal fasting (can't help water) 18 hours, administration (interval half an hour) at twice in one day, each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult's 50Kg body weight consumption.Continuous Observation 7 days after administration.
Three, result of the test:
In LD50 calculates when giving mice with maximum acceptable concentration and maximum allowable capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, seek maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, it was shown that acute toxicity is minimum, MTD > 18g/Kg.d.
Long term toxicity test data
The embodiment of the present invention 1 is through the gastric infusion long-term toxicity test for animals result of 6 months: SD rat is divided into three groups, often group 30, and male and female half and half (are divided into high, medium and low three dosage groups, often group 10), wherein first group through gavage to normal saline;Second group is 0.25g, 2.5g and 12.5g/kg.d through gavage to the dosage of the present invention;3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of lovastatin.During being administered, observe the indexs such as the clinical manifestation after the administration of each treated animal, hematology, blood biochemistry, organ coefficient and histopathology respectively and carry out the evaluation of drug toxicity.Result of study: the present lovastatin 50mg/kg.d of major toxicity reaction table and 5.0mg group, shows SD rat upon administration and occurs in that reaction and the symptoms such as sialorrhea, hair be fluffy, busy, diarrhoea, step, total food ration and losing weight;Blood test display total white blood cells increases to some extent, and Erythrocytes, content of hemoglobin and platelet count are decreased obviously (P all < 0.05);Blood biochemistry checking display ALT, AST, ALP and CK raise 1~8 times (P all < 0.05), and creatinine and blood urea nitrogen raise (P all < 0.05) to some extent, but do not cause animal dead;Histopathological analysis result display lovastatin 50mg/kg.d group occurs in that the Liver and kidney pathological change similar to people.And all there is not similar reaction with 0.25g of the present invention, three dosage groups of 2.5g and 12.5g/kg.d and lovastatin 0.5mg/kg.d dosage group during whole administration in normal saline group, during convalescent period observes, occur that the symptom of each treated animal of reaction fades away recovery normal condition.The visible present invention is not only able to reduce the toxic and side effects of lovastatin, and the clinical non-toxic of lovastatin can be made to increase to 5~25 times (P all < 0.01).
Cumulative toxicity is tested:
Mice is pressed 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight by the embodiment of the present invention 1, every day 2 times) and drug withdrawal 3 weeks after, result shows: the indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, each internal organs of rat are all without substantially changing.Illustrate that the embodiment of the present invention 1 is little to toxicity after rat long-term prescription, react also without difference after drug withdrawal, application safety.
Clinical trial:
Experimental subject: adopt health beverage of the present invention to test 100 example patients altogether, wherein male 48 examples, female 52 example;The oldest person 55 years old, age reckling 18 years old.Major part sufferer is white collar, readme blurred vision, nyctalopia;Insomnia forgetfulness, deficiency of the yin of the liver, two dryness and uneasy feeling of the eye, visual deterioration;Flaming up of liver-fire, conjunctival congestion and swelling pain;Frequent eyes are dry astringent, stay up late, dinner party of drinking;And dim complexion, female's sufferer mostly has menoxenia, and face is risen pox, and mottle is serious.Experimental group, matched group equal 50.Disease is same or like, adopts commercially available liver heat removing and eyesight improving collyrium+Chinese medicine conditioning.
Usage and dosage: treatment group adopts the embodiment of the present invention 1 health beverage.Its usage is as follows with consumption: drink 2 every day.The course for the treatment of: be limited for one month.Matched group daily Chinese medicine nostrum (QIJU DIHUANG WAN) adds dripping eyedrop (ZHENZHU MINGMU DIYANYE, commercially available), within one month, is limited.
The standard of curative effect evaluation
Cure: above symptom and sign improves completely, and patient is without any bad sensation, happy, in high spirits, and eyes are no longer dry astringent, blurred vision.Effective: sign significantly improves, patient is substantially without bad sensation, happy, and spirit is very well.Effective: sign substantially changes, random thoughts are slightly uncomfortable, but can accept, and mood is better, and energy is more abundant.Invalid: sign is without any change, and symptom is as before, feel depressed, and lethargy is depressed.Dim complexion, eyes or dry astringent.
Result organizes comparitive study (%) in 1 liang of Table
Group | Number | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
Treatment group | 50 | 37(74) | 11(22) | 2(4) | 0(0) | 100 |
Matched group | 50 | 25(50) | 12(24) | 8(16) | 5(10) | 90 |
Discuss: the treatment group effect of the present invention is apparently higher than matched group.Show that health beverage of the present invention replaces Chinese medicine feasible.It is an advantage of the invention that as daily drunk, mouthfeel can be improved, also allow people not produce to detest psychology, Chinese medicine odor is no longer repelled.
Commonly using computer office watching for a long time for city working clan, tobacco and wine are immoderate, and night life eye uncontrolled, excessive must less than the behavior of the injury livers such as alleviation, adopt qi-restoratives benefit vital essence, dispelling pathogenic wind for improving eyesight, the drug matching of nourishing the liver and kidney, and it is not good to solve Chinese medicine mouthfeel, it is impossible to the shortcoming of long-term taking.
Although above the specific embodiment of the present invention being given detailed description and explanation; but it should be noted that; above-mentioned embodiment can be carried out various equivalence according to the conception of the present invention and change and amendment by us; function produced by it still without departing from description contain spiritual time, all should within protection scope of the present invention.
Claims (6)
1. a health Dendranthemamorifolium beverage, it is characterized in that, described health Dendranthemamorifolium beverage includes the crude drug of following weight portion: Dendranthemamorifolium 20~50 parts, Herba Heliotroph 1~5 part, Herba Erodii 2~5 parts, Radix Ophiopogonis 1~5 part, 1~6 part of Folium Mori, Herba potamogetonis distincti 2~5 parts, Herba Plantaginis 3~6 parts, Herba Portulacae 2~8 parts, Herba Pentanematis Indici 1~4 part, Fructus Citri Sarcodactylis 1~6 part, Flos Inulae 1~6 part, Caulis Sinomenii 4~10 parts, Cortex Lycii 1~6 part, Flos Eriocauli 3~6 parts, Polygonum viviparum L. 1~6 part, Calyx Hibisci Sabdariffae 3~6 parts, Spica Prunellae 2~5 parts, Rhizoma Imperatae 2~8 parts, Herba Ardisiae Maculosae 1~4 part, Herba Hemisteptae Lyratae 2~5 parts, Herba Leonuri 2~8 parts.
2. health Dendranthemamorifolium beverage according to claim 1, it is characterized in that, described health Dendranthemamorifolium beverage includes the crude drug of following weight portion: Dendranthemamorifolium 30~50 parts, Herba Heliotroph 2~5 parts, Herba Erodii 2~5 parts, Radix Ophiopogonis 1~5 part, 1~6 part of Folium Mori, Herba potamogetonis distincti 3~5 parts, Herba Plantaginis 4~6 parts, Herba Portulacae 2~8 parts, Herba Pentanematis Indici 1~4 part, Fructus Citri Sarcodactylis 2~6 parts, Flos Inulae 3~6 parts, Caulis Sinomenii 4~10 parts, Cortex Lycii 2~6 parts, Flos Eriocauli 3~6 parts, Polygonum viviparum L. 2~6 parts, Calyx Hibisci Sabdariffae 4~6 parts, Spica Prunellae 2~4 parts, Rhizoma Imperatae 2~6 parts, Herba Ardisiae Maculosae 2~4 parts, Herba Hemisteptae Lyratae 2~5 parts, Herba Leonuri 2~6 parts.
3. health Dendranthemamorifolium beverage according to claim 1, it is characterized in that, described health Dendranthemamorifolium beverage includes the crude drug of following weight portion: Dendranthemamorifolium 45 parts, Herba Heliotroph 3 parts, Herba Erodii 4 parts, Radix Ophiopogonis 2 parts, 3 parts of Folium Mori, Herba potamogetonis distincti 4 parts, Herba Plantaginis 5 parts, Herba Portulacae 3 parts, Herba Pentanematis Indici 2 parts, Fructus Citri Sarcodactylis 4 parts, Flos Inulae 4 parts, Caulis Sinomenii 6 parts, Cortex Lycii 5 parts, Flos Eriocauli 4 parts, Polygonum viviparum L. 5 parts, Calyx Hibisci Sabdariffae 6 parts, Spica Prunellae 2 parts, Rhizoma Imperatae 3 parts, Herba Ardisiae Maculosae 3 parts, Herba Hemisteptae Lyratae 4 parts, Herba Leonuri 6 parts.
4. the preparation method of health Dendranthemamorifolium beverage as according to any one of claims 1 to 3, it is characterised in that the preparation method of described health Dendranthemamorifolium beverage comprises the following steps:
A. the extraction of Dendranthemamorifolium, as component one;
B. all the other crude drug described chopping is extracted as component two;
C. component one and component two are mixed, add proper honey after concentration and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.
5. the preparation method of health Dendranthemamorifolium beverage according to claim 4, it is characterised in that in described step a, the Dendranthemamorifolium of collection is steeped in 10 times amount ethanol after 2-7 days, heating extraction 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-110 order filters, the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 then through damming, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component one.
6. the preparation method of health Dendranthemamorifolium beverage according to claim 4, it is characterised in that in described step b, being mixed by all the other raw medicinal materials, shredded 100~120 mesh sieves, after sieving, fine powder is standby, coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, impregnate together with more than 70 degree ethanol 15~30 days, then heating and refluxing extraction 2 times, each 1~2 hour, 2 extracting solution are merged and stands, filter, after separation, take filtrate;By filtered through gauze, adding 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, and being condensed into pasty state becomes component two.
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